@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0572: (2015-12-16 )
MKATQSTINDFFALTGTIFSIPVYQRNYTWEEENCEKLLQDIVNISQNKKTHFMGSITYILHLIDDEKSLRQLQEFVIIDGQQRITTIMLLLKAIETKIQNEGIKKEIDGLLNLSGQRLRLKPIKSDKEAFDLVMQNRSHEIQGVSHIKNNYKFFTKELDNYISKGYRIEEIYGAFLWLKIVAIGLELGEDDPQVVFESINATGVQLKGLDLIRNYLMMGENSDNQNRLYNTYWVPLENWLGEKDLNDFIKTYLRIYFEDRVKEGEREVYYALKAHHRDNFPNNIQGLMSDMREYGRIFQIFLDRDHYFLHRGDPQQLANLRLRVKDLVKIKFGVAKPFVLRCARDFEEGKLDYENFHEILQILISYFVRRSVCGDSTPTLTRVLYSLYRQLGEDVSADALKRYLGKSVGQMAFPNDDKIKAAFLVRNAYAANQVCKFILLEIEKLSNAEPPKEENLEVEHFYPKTPTQEWRDRVGDYFTFEQDYLNNFGNLTLSGQNQRLGNKSYEAKIALMEEYSSLHLNDYFTNNTDSWGIEEVRARSEYLADQFCQVGLFKDLPKEYRARELHKTLDDNLTNHNLQSVKLPNDQRRMAGNAKELASVVIDYLLENAREAFESYTDDESQKYIYWSKAKAEARDRDGTLVVPFEKYGFYFVSNASYQTTGSNLKDLILGCNLNPRDFVVE
Atome Classification :
(20 SA)
---------------------------------------------------------------.........10.....------.---..20......-..30..--......40........50--------------...-..-....60....------------------....70.....-.-----------------...80....-....----------90........100-----.........110---.......120.......130---.--.....-..140.......150....-----...160..-.....170..----...-...180-----.......--190..-.....200.....-.----------..210......-..220--.-......230.-----------......240...----------.-.---..250..-.....-------260...-....-----.270..---...-...-280-.....-...290.........300--..------.-..-----..310---.....--------...320....------...330.......--340.......-350...-....360--.........370--......-..380.....--.------.390....--...400------.......----410.....--------..420..-....---------------------.430....-----------...440..---..-...450....----------------...460...--...-----------.470..----------.-....--------480.--.....-.490..--------.....500-.--------------.----......510--------...-....520----......-.530.--..----....540.......550.-......560.......570....----.-..580....-...590........600------.....--------------..610.......-----620..-..----.....630...--..-------...640.-------..---------...-----.650.......660.......670..--------.....680.----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------MK
A
T
Q
S
T
I
N
D
F
F
A
LT
G
------
T
---
I
F
S
I
P
V
Y
QRN-YTW
E
E
E
--
N
C
E
K
L
L
Q
D
I
V
N
ISQNKK---------------
T
H
F
-
M
G
-
S
I
T
Y
I
L
H
LID------------------
D
E
K
S
L
-
R
Q
L
Q
E
-
F
-----------------
V
I
IDG
Q
Q
R
I
-
T
T
I
M
----------
L
L
L
K
A
I
E
T
K
IQ-------NE
G
I
K
K
E
I
D
G
L
L
---NLSG
Q
R
L
R
L
KPIKS
D
K
E
A
F
----
D
--
L
V
M
QN-RSHEIQ
G
V
S
H
I
K
N
N
Y
K
F
F
T
-----
K
E
L
D
N
Y
I
S-KGY
R
I
E
E
-
I
Y
----
G
A
F
-
L
W
L
K
I
V
-----
A
I
G
LELG--ED
D
P
Q
-
V
V
F
E
SIN-ATG
V
Q
-
L
----------K
G
L
-
D
L
I
R
N
Y
L
-MMGEN--S-DNQ
N
R
L
Y
N
T
Y
-----------
W
V
P
L
E
N
WLG
E
K
D
----------
L
-
N
---
D
F
I
K
T
Y
L
-
R
I
Y
F
E
-------
D
-
R
VKE-GER
E
-----
V
Y
-
Y
A
L
---
K
A
H
-HRD-NF--P
N
N
I
Q
-
G
L
M
S
--
D
M
R
E
Y
G
R
I
F
Q
I
F
--LD------R-D
H
-----
Y
F
L-H---RG
D
P
Q
--------
Q
L
A
N
L
R
L
R
V
K
------
D
L
V
K
IKFGVA
K
P
F
--
V
L
R
C
A
R
D
F
E
E-GKL
D
Y
E
-
N
F
H
E
I
----
L
Q
I
L
I
S
Y
F
V
R
R
---SVCGDS-T
P
T
L
T
R
V
L
Y
S
--
L
------
Y
R
Q
LGEDV--
S
A
D
A
L
K
------
R
Y
L
G
K
S
V----GQMAFPND--------DK
I
K
A
A
F
-
L
VRN---------------------
A
Y
A
A
N
Q
V
C
-----------
K
F
I
L
L
E
I
E
---
K
L-SNAEPPKEEN----------------L
E
V
E
H
FYPK--T
P
T
-----------
Q
E
W
R
D
R----------V-GD
Y
F
--------
T
F
E
Q
--
D
Y
L
N
N-FG
N
L
T
L--------SGQNQR-L-G--------------N----KS
Y
E
A
K
I
A
L
--------
M
E
E
-
Y
S
SLHLN----DYFTNN-TDSW
G
--
I
E
----
E
V
R
A
R
S
E
Y
L
A
D
Q
F
C
QV
G
L
-
F
K
DL
P
K
E
Y
R
A
R
E
L
H
K
T
L
DDNLTN----H-NL
Q
S
VKLP
N
-
D
Q
R
R
-MAG
N
A
K
E
L
A
S
V
V
------
I
D
Y
L
L
--------------
E
N
A
R
E
A
F
E
SYTD-----D--ES-Q
K
----
Y
I
Y
W
SK-AKAE--AR-------DRDG
T
L
V
-------
V
P
---------FEK-----Y
G
F
Y
F
VSNASYQTTGS
N
L
K
D
L
ILGCN--------L
N
P
R
DFVVE----------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
78.72
19%
-20
- C5 -
4BJU
1
?
A:
[1-548]
---------------------------------------------------------MAS
P
A
V
R
K
A
I
S
D
A
A
L
Q
Y
A
K
P
E
G
------
K
---
I
F
Q
---
Y
G
T
A
G
F
R
M
K
A
D
--
L
-----------------------------------
L
N
-
T
V
V
Y
A
V
G
L
L
A
------------------
T
L
R
S
K
-
K
-------------------------
L
S
G
Q
-----
W
I
G
----------
V
M
V
T
A
S
H
N
P
A
E
-------
D
N
G
V
K
-----
L
V
---
D
P
M
G
E
M
L
E
-----
A
E
W
E
A
Y
----
A
--
T
K
L
A
N
-
A
P
-----
L
E
N
I
G
D
V
Y
D
E
L
V
-----
K
E
I
D
V
S
M
E
-
N
P
A
R
V
V
F
-
A
R
DTRA
S
G
S
-
R
L
I
G
V
L
-----
S
A
A
L
T
A
T
--
E
-----
A
E
F
I
D
M
K
F
M
T
T
P
Q
-
L
----------
H
Y
V
-
V
R
C
K
N
T
L
---
G
T
Q
--
Y
-
E
Y
G
E
P
T
E
Q
G
Y
-----------
Y
E
K
L
A
A
A
F
K
R
V
M
----------
R
-
G
---
V
K
V
K
G
S
L
-
T
V
D
C
A
-------
N
-
G
V
---------------
G
G
P
---
K
L
R
-
E
L
I
-
K
Y
--
L
P
E
D
T
-
G
L
-------------
D
I
K
--
I
V
------
N
-
D
D
-----
V
I
--------
N
P
D
--------
S
L
-------------------
N
F
E
C
G
A
D
Y
--
V
K
T
K
Q
R
A
P
P
S
-
S
K
A
S
I
L
-
D
----------------
R
C
A
---
S
L
D
G
D
A
-
D
----
R
I
L
Y
Y
--
F
L
DEG
N
V
F
R
L
L
D
G
D
R
--
I
A
T
L
A
A
------
S
F
I
G
D
L
A
----
R
S
A
G
I
A
Q
K
--------
L
K
I
---
G
-
V
V
Q
T
---------------------
A
Y
A
N
G
S
S
T
-----------
E
Y
I
E
K
V
L
K
---
L
P
-
S
V
C
T
N
T
G
V
K
H
----------------
L
H
H
A
A
M
----------------------
R
F
D
----------
V
-
G
V
Y
F
EANGH
G
T
I
T
F
S
E
--
N
A
L
K
T
-
I
K
N
T
E
P
--------
Q
-----------------------
S
----
P
A
Q
Q
R
S
L
E
C
--------
L
Q
A
-
L
T
D
L
-
I
N
----
Q
A
V
G
D
A
I
S
D
M
L
L
--
V
E
----
A
I
L
A
H
K
G
W
T
P
K
E
W
L
A
T
---
Y
T
D
L
P
S
R
L
V
R
V
E
V
A
E
-------
R
----
S
-
I
F
K
A
Y
D
A
E
R
-
K
L
E
S
-
P
P
G
L
Q
A
K
I
D
S
L
Q
------
S
R
Y
----------------
N
K
G
R
S
F
A
R
A
S
G
T
-----
E
--
D
A
-
V
R
----
V
Y
A
E
A
A
-
S
R
S
E
--
A
D
-------
D
L
A
T
R
V
A
-------
N
A
---------
V
R
D
-----
A
G
----------
T
V
K
E
I
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
71.33
18%
-31
* C7 *
4C91
2
?
A:
[32-854]
-----------------------------EQFVIF
T
P
A
G
NHFPLVANG
V
P
C
P
I
Y
I
D
SSED
K
G
V
M
I
A
A
G
N
L
Q
Q
D
I
L
Q
V
C
G
------
K
K
P
E
L
L
T
S
T
S
S
K
R
C
-
I
I
A
G
T
Y
--
G
-
T
P
F
I
K
K
L
M
S
A
G
K
I
D
K
---------------
K
E
L
-
D
G
K
N
E
K
Y
I
L
Q
V
I
A
------------------
N
--
P
C
-
E
G
I
D
E
-
A
-----------------
V
V
I
I
G
S
D
R
R
-
G
T
I
Y
----------
G
I
Y
E
L
S
E
Q
M
G
V
SPWYWWA
D
V
P
V
M
K
Q
A
N
V
Y
I
---
K
-
P
G
Q
Y
S
D
G
E
P
A
V
T
Y
R
G
I
F
LNDE
A
--
P
C
L
T
R
-
W
V
K
H
T
Y
G
T
N
Y
--
G
D
H
R
F
Y
A
-----
R
V
C
E
L
I
L
R
---------
L
K
----
G
N
F
-
L
W
--
P
A
-----
M
W
S
W
A
F
Y
--
A
D
D
P
Q
-
N
S
-
K
T
A
S
-
E
M
G
V
I
-
I
G
T
S
HHEPMAR
N
H
Q
-
E
W
S
R
K
R
K
-
E
Y
G
A
W
DY
T
-
T
N
Q
K
V
I
D
Q
F
F
-----------
R
E
G
I
E
R
M
Q
G
T
E
D
I
V
T
I
G
MN
V
K
L
L
-
E
---
N
V
V
K
N
Q
R
-
K
I
I
E
E
-------
V
-
T
K
R
P
-
A
K
E
T
P
Q
V
W
A
L
Y
-
K
E
V
---
L
D
Y
-
Y
D
K
-
G
M
R
V
P
D
D
V
I
-
M
L
L
C
--
D
-
D
N
W
G
N
V
C
R
L
P
N
A
K
E
------
R
-
K
H
PG
G
W
G
M
Y
Y
-
H
VDY
V
G
A
P
R
NSKWLNVT
P
I
Q
N
M
W
E
Q
L
Q
------
L
T
Y
D
--
Y
G
V
E
K
L
W
--
I
L
N
V
-------
G
D
L
K
P
M
-
E
Y
P
I
T
----
L
F
M
D
M
A
W
N
P
K
Q
---
F
---
N
V
-
S
N
L
L
D
H
P
R
R
F
--
C
------
A
Q
Q
F
G
E
D
Q
--
A
D
E
A
M
R
I
L
N
L
Y
S
K
Y
N
G
R
V
T
----
G
E
M
L
D
R
N
T
YNLETG
E
W
K
Q
V
S
D
E
Y
-
L
K
L
E
---------------------
A
E
A
L
R
Q
Y
I
S
LKPEY
K
D
A
Y
K
Q
L
I
L
F
P
V
Q
---
A
M
-
A
N
L
Y
E
M
Y
Y
A
Q
----------------
A
M
N
H
K
L
Y
K
E
NN
P
Q
A
-----------
N
E
W
A
D
K
----------
V
-
E
Q
A
F
--------
A
R
D
K
--
A
L
S
D
D
-
Y
N
N
I
M
S
--------
G
G
K
W
K
N
-
M
-
M
IQKHIGYTSWNDNF
P
----
A
D
T
L
P
K
I
Y
R
--------
I
E
N
-
P
E
K
A
V
G
G
----
Y
V
F
T
G
Q
-
D
G
Y
I
A
--
I
E
----
A
E
H
Y
Y
S
A
K
A
A
P
D
-
T
E
W
T
V
-
I
P
Y
M
G
R
T
L
S
G
M
A
L
M
P
Y
T
Q
P
T
D
G
A
----
S
-
I
S
Y
K
I
K
L
P
K
--------
G
I
D
K
V
T
V
H
V
I
------
V
K
S
T
L
AFHDRK
G
H
E
Y
S
I
G
F
E
G
G
K
D
Q
T
I
N
F
N
H
NLNEL
P
--
E
N
-
V
Y
----
S
I
Y
Y
P
T
-
V
A
R
R
--
I
V
-------
E
K
K
A
K
L
N
-------
V
P
---------
N
T
S
-----
D
G
M
Q
T
I
T
F
K
P
L
D
P
-
G
I
V
L
E
K
L
V
V
D
Y
G
GYKKSYLF
M
N
E
S
K
S
K
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
68.98
15%
-25
- C5 -
3K8T
3
RIR1_YEAST
A:
[90-746]
---------------------------------------------------------------------
T
T
K
Q
F
S
K
V
V
E
------
D
---
L
Y
R
---
Y
V
N
A
-
A
T
G
K
P
A
--
P
--
M
I
S
D
D
V
Y
N
I
V
M
E
N
K
---------------
D
K
L
-
N
S
-
A
I
V
Y
D
R
D
F
Q
Y
------------------
S
Y
F
G
F
-
K
T
L
E
R
S
Y
-----------------
L
L
R
I
N
G
Q
V
A
-
E
R
P
Q
----------
H
L
I
M
R
V
A
L
G
I
H
-------
G
R
D
I
E
A
A
L
E
T
Y
N
---
L
M
S
L
K
Y
F
T
H
--------
A
S
----
P
--
T
L
F
N
A
-
G
T
P
K
P
Q
M
S
S
C
F
L
V
A
M
K
------------------
E
D
S
I
E
G
-
I
Y
----
D
T
L
-
K
E
C
A
L
I
S
K
T
A
G
G
I
G
L
H
I
----
H
N
I
R
-
S
T
G
S
Y
I
A
-
G
T
N
G
T
-
S
----------
N
G
L
I
P
M
I
R
V
F
N
-
N
T
A
R
Y
--
V
-
D
Q
G
G
P
--
G
A
F
-----------
A
L
Y
L
E
P
W
--
H
A
D
----------
I
-
F
---
D
F
I
D
I
R
K
-
N
---
H
-------
G
-
K
E
E
I
-
R
A
R
D
-----
L
F
-
P
A
L
WIP
D
L
F
-
M
K
R
-
V
E
--
E
N
G
T
W
-
T
L
F
S
PT
S
A
P
G
L
S
D
C
Y
G
D
E
--
F
E
------
A
-
L
Y
-----
T
R
Y
-
E
---
K
E
G
R
G
--------
K
T
I
K
A
Q
K
L
W
Y
------
S
I
L
E
A
Q
T
E
T
G
T
P
F
--
V
V
Y
--
K
D
A
C
N
-
R
K
S
N
Q
K
-
N
L
G
V
I
KSSN
L
C
C
E
I
V
E
Y
S
A
P
D
E
T
A
V
C
N
L
A
-
S
V
A
L
P
A
F
I
E
K
T
S
T
------
Y
N
F
K
K
L
H
E
--
I
A
K
V
V
T
------
R
N
L
N
R
V
I
----
D
R
N
Y
Y
P
V
E
--------
E
A
R
K
S
N
M
-
R
H
R
P
---------------------
I
A
L
G
V
Q
G
L
-----------
A
D
T
F
M
L
L
R
LPF
D
S
-
E
E
A
R
L
L
N
I
Q
I
----------------
F
E
T
I
Y
H
A
S
M
--
E
A
S
-----------
C
E
L
A
Q
K
----------
D
-
G
P
Y
E
--------
T
F
Q
G
--
S
P
A
S
Q
--
G
I
L
Q
F
--------
D
M
W
D
Q
K
-
P
-
Y
--------------
G
MWD
W
D
T
L
R
K
D
I
M
K
--------
H
G
V
-
R
N
S
L
T
M
A
----
P
M
P
T
A
S
-----------------------
T
S
Q
I
L
G
Y
N
E
-
C
F
E
P
V
T
S
N
M
Y
Q
V
V
N
P
Y
L
L
R
D
L
V
D
----
L
-
G
I
W
D
E
G
M
K
Q
-
Y
L
I
T
-
Q
N
G
S
I
Q
G
L
P
N
V
-----------
P
--------------
Q
E
L
K
D
L
Y
K
T
V
W
E
-----
I
--
S
Q
-
K
T
----
I
I
N
M
A
A
-
D
R
S
V
--
Y
I
-------
D
Q
S
H
S
L
N
-------
L
F
---------
L
R
A
-----
P
T
M
G
K
L
T
S
M
H
F
Y
G
W
K
K
G
L
K
T
G
M
Y
--
Y
--------
L
R
T
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
65.30
16%
-26
- C3 -
4HNY
4
NAT1_YEAST
A:
[54-862]
----------------------------------------------------------------------
V
D
S
L
A
L
K
G
L
------
D
---
L
Y
S
V
G
E
K
D
D
A
-
A
S
Y
V
A
N
A
I
R
A
S
P
I
C
C
H
V
L
G
I
Y
M
R
N
T
---------------
K
E
Y
-
K
E
-
S
I
K
W
F
T
A
A
L
N
------------------
N
G
S
T
N
-
K
Q
I
Y
R
-
D
-----------------
L
A
T
L
Q
S
Q
I
G
-
D
F
K
N
----------
A
L
V
S
R
K
K
Y
W
E
A
-------
F
L
G
Y
R
A
N
W
T
S
L
A
V
A
Q
D
V
N
G
E
R
Q
Q
A
I
N
T
L
S
Q
F
E
K
L
----
A
EG
K
I
S
D
S
-
E
K
Y
E
H
S
E
C
L
M
Y
K
N
D
I
M
Y
K
A
A
SDN
Q
D
K
L
Q
N
V
L
K
-
H
L
N
D
I
E
P
C
V
F
----
D
K
F
G
L
L
E
R
K
A
-----
T
I
Y
M
K
L
G
Q
L
K
D
A
S
I
-
V
Y
R
T
L
I
K
-
R
N
P
D
N
-
F
----------
K
Y
Y
-
K
L
L
E
V
S
L
-
G
I
Q
G
D
--
N
-
K
L
K
K
A
L
Y
G
K
L
E
Q
F
YPRCEPPK
F
I
P
L
T
F
L
Q
D
K
E
E
----------
L
-
S
---
K
K
L
R
E
Y
V
-
L
P
Q
L
E
R
GVPA
T
F
S
-
N
V
K
P
-
L
Y
Q
R
-----
R
K
-
S
K
V
---
S
P
L
-
L
E
K
-
I
V
--
L
D
Y
L
S
-
G
L
D
P
--
T
Q
D
P
I
P
F
I
W
T
N
Y
--
Y
L
------
S
-
Q
H
-----
F
L
F
-
L
---
K
D
F
P
K
--------
A
Q
E
Y
I
D
A
A
L
D
H
TPTL
V
E
F
Y
I
L
K
A
R
I
L
K
H
L
GL
M
D
T
A
A
G
I
L
E
E
-
G
R
Q
L
D
L
-
Q
D
R
F
I
----
N
C
K
T
V
K
Y
F
L
R
-------
A
N
N
-
I
D
K
A
V
E
V
A
-
S
--
L
------
F
T
K
N
D
D
S
V
------------------
N
G
I
----
K
D
L
H
L
V
------------
E
A
S
W
F
-
I
V
E
Q
---------------------
A
E
A
Y
Y
R
L
Y
-----------
L
D
R
K
K
K
L
D
---
D
L
A
S
Q
I
A
N
D
I
K
E
N
----------------
Q
W
L
V
R
K
Y
K
G
--
L
A
L
-----------
K
R
F
N
A
I
----------
P
-
K
F
Y
K
--------
Q
F
E
D
--
D
Q
L
D
F
-
H
S
Y
C
M
R
--------
K
G
T
P
R
A
-
Y
-
L
--------------
E
----
M
L
E
W
G
K
A
L
Y
TK
P
M
Y
V
R
A
M
K
E
-
A
S
K
L
Y
F
Q
M
H
D
-
D
R
L
K
R
K
-
S
D
S
L
D
--
E
N
DVFG
E
K
L
I
E
T
S
T
P
M
E
D
F
A
T
E
-
F
-
Y
N
N
Y
S
M
Q
V
R
E
D
E
R
D
Y
I
L
D
F
E
F
N
Y
R
I
GK
L
-
A
L
C
F
A
S
L
N
K
-
F
A
K
R
-
F
G
T
T
S
G
L
F
G
S
M
A
------
I
V
L
L
H
A
T
RPFD--------
P
I
L
K
K
V
V
T
K
S
L
E
-----
K
--
E
Y
-
S
E
----
F
D
W
L
N
F
-
Y
Q
E
K
FG
K
N
-------
D
I
N
G
L
L
F
L
Y
R
Y
R
DD
V
P
---------
I
G
S
-----
S
N
L
K
E
M
I
I
S
S
L
S
P
L
E
P
H
S
Q
N
E
I
L
Q
Y
Y
--------
L
Y
P
Y
D
V
P
D
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
60.35
13%
-9
- C5 -
1PGJ
3
6PGD_TRYBB
B:
[1-478]
----------------------------------------------------------------
S
M
D
V
G
V
V
G
--
L
G
V
M
G
------
A
---
N
L
A
L
N
I
A
E
K
G
-
F
K
------------
V
A
V
F
N
R
T
Y
S
K
S
---------------
E
E
F
-
M
K
-
A
-
N
A
S
A
P
F
A
G
------------------
N
L
K
A
F
-
E
T
M
E
A
-
F
-----------------
A
A
S
L
K
K
P
R
---
K
A
L
----------
I
L
V
Q
A
-------------
G
A
A
T
D
S
T
I
E
Q
L
K
---
K
V
F
-------------
E
K
G
----
D
--
I
L
V
D
T
-
G
----------
N
A
H
F
K
D
Q
G
-----
R
R
A
Q
Q
L
E
A
-
A
G
--------------------
L
R
-----
F
L
G
M
G
I
S
--
G
G
E
E
G
-
A
R
K
G
P
A
F
-
F
P
G
G
T
-
L
----------
S
V
W
-
E
E
I
R
P
I
V
-
E
A
A
A
A
--
K
-
A
D
D
G
R
------------------
P
C
V
T
M
N
G
S
G
G
----------
A
-
G
---
S
C
V
K
M
-
Y
-
H
N
S
G
E
-------
Y
-
A
I
L
Q
-
I
W
G
E
-----
V
F
-
D
I
L
---
R
A
--
M
G
L
-
N
---
N
D
E
V
A
-
A
V
L
E
--
D
W
K
S
K
N
F
L
K
S
Y
M
--
L
D
------
I
-
S
I
-----
A
A
A
-
R
---
A
K
D
K
D
--------
G
--------------------------------------------------------------------------------------------------
S
Y
L
T
E
H
V
--
M
D
R
I
G
S
------
K
G
T
G
L
W
S
----
A
Q
E
A
L
E
I
G
--------
V
P
A
P
S
L
N
-
M
A
V
V
---------------------
S
R
Q
F
T
M
----------------
Y
K
T
E
R
---
Q
A
-
N
A
S
N
A
P
G
I
T
Q
----------------
S
P
G
Y
T
L
K
N
K
--
S
P
S
-----------
G
P
E
I
K
Q
----------
L
-
Y
D
S
V
--------
C
I
A
I
IS
C
Y
A
Q
M
-
F
Q
C
L
R
E
--------
M
D
K
V
H
-----------------------------------------------------------------
N
F
G
--
L
N
----
L
P
A
T
I
A
T
F
R
A
G
C
I
L
Q
G
Y
L
-
L
K
P
M
T
E
A
F
E
K
N
P
N
I
S
N
L
M
C
---
A
----
F
-
Q
T
E
I
R
A
G
L
Q
-
N
Y
R
D
-
M
V
A
L
I
T
S
K
L
E
V
S
------
I
-
P
V
L
--------------
S
A
S
L
N
Y
V
T
A
M
F
T
-----
P
--
T
L
-----------
K
Y
-
G
Q
L
V
--
S
L
-------
Q
R
D
V
F
G
R
-------
H
G
---------
Y
E
R
-----
V
D
K
D
G
R
E
S
F
Q
W
P
----
E
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
59.25
17%
22
* C6 *
4P37
11
?
A:
[7-517]
---------------------------------------------------------------
N
R
N
R
K
L
S
Y
Q
E
Y
Y
V
-------------------------
D
G
D
Y
E
--
E
V
R
K
K
L
P
E
I
I
K
Q
A
R
I
K
A
---------------
S
Q
V
M
E
P
-
T
-------
I
Y
------------------
E
K
R
V
V
M
E
I
I
K
D
-
F
-----------------
I
R
D
K
G
R
-
K
V
-
Y
G
G
T
----------
A
L
N
E
T
I
K
K
K
N
P
-------
E
D
A
I
Y
---
D
S
Y
L
---
F
S
D
I
E
F
Y
S
P
T
P
V
P
D
L
K
E
L
C
----
D
--
I
L
Y
H
K
-
G
Y
D
P
V
Q
G
K
E
A
--------------------------
Q
H
E
E
-
T
Y
----
S
I
F
-
V
N
L
Q
L
Y
-----
C
D
I
T
Y
V
------
P
T
-
K
V
Y
H
G
I
K
---
T
I
E
-
I
----------
D
G
I
-
N
Y
T
H
P
H
F
M
L
I
D
Y
L
--
R
M
I
N
Q
-----
P
L
-----------
T
A
A
E
Q
R
W
E
K
A
F
D
----------
R
M
Y
---
V
L
L
K
N
Y
P
M
E
K
Y
D
N
-------
S
M
R
I
T
S
-
P
R
D
D
-----
I
Q
M
Y
I
G
---
K
V
K
-
S
E
F
M
K
I
--
P
E
I
Q
E
S
C
L
I
S
--
G
F
D
A
Y
N
F
F
I
R
H
A
M
-
G
D
------
R
-
S
L
-----
K
N
F
-
I
---
T
V
L
P
F
M
-------
E
L
I
S
V
K
--------------------------------------------
Y
K
D
T
----
V
E
K
L
Y
N
F
L
R
E
K
----
V
V
N
P
D
-
L
I
T
I
D
E
Y
-
F
P
--
L
------
F
Q
F
T
G
Y
S
V
--
S
I
N
Y
D
G
---------------------------------------
I
-
P
I
V
K
---------------------
V
Y
E
A
D
G
Y
C
---------------------------------------------------------
V
P
D
--
I
K
T
-----------
T
S
-----------------------------------------
G
Y
R
Y
V
--------
S
Y
Q
Y
I
L
M
I
M
Y
--------------
I
----
S
K
F
K
A
H
L
D
K
--------
N
K
E
M
Y
--------------
F
N
-
Y
G
I
A
I
--
S
N
----
L
V
Q
A
R
N
S
Y
L
N
Q
K
--
N
I
G
V
-
I
N
D
-----------
T
V
F
S
E
F
R
I
G
----
C
-
I
G
T
T
V
S
Y
T
R
M
S
R
L
R
M
L
---
E
K
K
K
Q
G
K
V
------
I
Q
F
V
Y
--------------
T
----
P
K
Q
Y
F
S
Q
-----
T
--
P
E
-
Q
Q
----
N
N
F
D
E
S
M
K
K
Y
R
--
F
K
-------
N
T
S
G
N
K
I
-------
T
I
---------
P
K
N
-----
L
L
F
K
I
D
E
R
G
N
I
S
E
E
I
S
T
E
E
A
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
54.48
10%
-35
- C4 -
3SK7
-
?
A:
[88-169]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
M
L
I
------
L
S
T
L
H
--------------
R
I
D
S
A
S
F
S
E
A
T
M
-----
F
-----
R
V
----
Y
F
A
D
N
E
-
Q
T
L
L
--
A
S
-------
G
Q
T
-
T
K
P
-------
K
A
---------
I
P
N
-----
T
P
F
W
V
I
T
N
N
N
T
S
R
K
Q
Q
M
V
E
Q
V
M
V
R
M
G
--------
F
P
S
D
I
I
E
K
V
----------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
54.31
14%
-14
- C2 -
4MT1
-
?
A:
[2-1040]
A
K
F
F
I
D
R
P
I
F
A
W
V
I
S
I
F
I
I
A
A
G
I
F
G
I
K
S
LPVSQYPSVA
A
P
T
I
T
L
H
A
I
Y
PGAS
A
Q
V
M
E
G
SV
L
S
V
I
E
R
N
M
N
G
V
E
G
L
D
Y
M
S
T
------
S
---
A
D
S
S
G
S
G
S
V
S
-
L
T
F
T
P
D
--
T
D
E
N
L
A
Q
V
E
V
Q
N
K
L
S
E
V
LSTLP
A
T
V
Q
Q
Y
G
V
T
V
S
K
A
-
R
S
-
N
F
L
M
I
V
M
L
S
S
------------------
D
V
Q
S
T
-
E
E
M
N
D
-
Y
A
Q
R
N
V
VPELQRIEGVG
Q
V
R
L
F
G
A
Q
R
A
-
M
R
I
W
V
D
P
K
K
L
Q
N
Y
N
L
S
F
A
D
V
G
S
A
L
S
-------
A
Q
N
I
Q
I
S
A
G
S
I
G
---
S
L
P
A
V
R
G
Q
T
V
T
A
T
V
T
A
Q
G
-----------
Q
L
-
G
T
A
E
E
F
G
N
V
I
L
R
A
N
T
D
G
S
N
-----
I
Y
L
K
D
V
A
K
-
V
G
L
G
M
E
D
-
Y
S
----
S
S
T
-
R
L
N
G
V
N
-----
T
T
G
M
A
V
M
--
L
S
N
S
G
-
N
A
M
A
T
A
K
-
A
V
K
E
R
-
L
----------
A
V
L
-
E
K
Y
F
P
Q
G
-
M
S
W
K
T
--
P
-
Y
D
T
S
K
F
V
E
I
S
-----------
I
E
K
V
I
H
T
L
I
E
A
M
----------
V
-
L
---
V
F
V
V
M
Y
L
-
F
L
Q
N
I
-------
R
-
Y
T
L
I
-
P
T
I
V
-----
V
P
-
I
S
L
---
L
G
G
-
F
A
F
-
I
S
--
Y
M
G
M
S
-
I
N
V
L
--
T
M
F
A
M
I
L
V
I
G
I
V
--
V
D
D
A
I
V
V
V
E
-
N
V
-----
E
R
I
-
M
---
A
G
E
G
L
--------
P
P
K
E
A
T
K
K
A
M
------
G
Q
I
S
G
A
V
I
G
I
T
A
V
--
L
I
S
V
F
V
P
L
A
M
F
S
G
A
A
G
N
-
I
Y
K
Q
F
----
A
L
T
M
A
S
S
I
A
F
S
---
A
F
L
A
L
T
L
T
P
A
L
C
A
T
G
F
F
--
G
------
W
F
N
K
K
F
D
S
--
W
T
H
G
Y
E
------
G
R
V
A
K
V
L
R
K
T
F
R
M
M
V
V
Y
I
G
--------
L
A
V
V
G
V
F
-
L
F
M
R
L
P
T
S
F
L
PTEDQG
F
V
M
V
S
V
Q
L
P
A
G
A
T
K
E
R
T
-----------
D
A
T
L
A
Q
V
T
---
Q
L
-
A
K
S
-
I
P
E
I
E
N
----------------
I
I
T
V
S
G
F
S
F
--
S
G
S
GQN
M
A
M
G
F
AIF
K
D
W
N
E
R
TASGSD
A
V
A
V
A
-
G
K
L
T
--------
G
M
M
M
--
G
T
L
K
D
G
F
G
I
A
V
V
P
P
PILELG
S
G
L
S
I
N
-
L
-
Q
--------------
D
----
R
N
N
T
G
H
T
A
L
--------
L
A
K
-
R
N
E
L
I
Q
K
M
R
A
S
G
L
F
D
P
S
-
T
V
R
A
G
G
L
E
D
----
S
P
Q
L
K
I
D
I
N
R
A
A
A
A
A
Q
G
I
S
F
A
D
I
R
T
A
L
A
S
A
L
S
S
S
Y
V
S
D
F
P
N
Q
----
G
-
R
L
Q
R
V
M
V
Q
A
-
D
E
D
A
-
R
M
Q
P
A
D
I
L
N
L
T
V
PNKSG
V
A
V
P
L
S
--------------
T
I
A
T
V
S
W
E
N
G
T
E
--------
Q
S
-
V
R
----
F
N
G
Y
P
S
-
M
K
L
S
--
A
S
PATGVST
G
Q
A
M
E
A
V
-------
Q
K
---------
M
V
D
E
L
GGG
Y
S
F
E
W
G
G
Q
S
S
E
E
A
K
G
G
S
Q
T
L
I
L
Y
G
L
A
--------
V
A
A
V
F
L
V
L
A
A
L
Y
ESW
S
I
P
L
A
V
I
L
V
I
P
L
G
L
I
G
A
A
A
G
V
T
G
R
N
L
F
E
G
L
LGSVPSFAND
I
Y
F
Q
V
G
F
V
T
V
M
G
L
S
A
K
N
A
I
L
I
I
E
F
A
K
D
L
Q
A
Q
GKS
A
V
E
A
A
L
E
A
A
R
L
R
F
R
P
I
I
M
T
S
F
A
F
I
L
G
V
V
PLYIAAGAS
S
A
S
Q
R
A
I
G
T
T
V
F
W
G
M
L
V
G
T
L
L
S
V
F
L
V
P
L
F
Y
V
V
V
R
K
F
F
48
Fugue
48.83
16%
-27
* C5 *
3GN6
6
?
A:
[22-321]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
P
W
T
D
A
A
----------
L
-
D
---
T
I
V
N
Q
A
L
-
T
L
Y
A
E
M
------
R
--------------------
V
---
V
P
A
-
H
H
D
-
A
F
--
L
A
A
I
D
-
T
V
S
A
--
K
L
R
V
L
P
G
F
L
S
L
A
--
L
K
------
Q
M
S
G
-----
D
S
T
M
V
---
K
N
Y
P
E
--------
T
Y
K
G
V
-
L
A
T
A
------
Y
L
D
G
V
A
A
G
T
Q
P
Y
F
--
Y
N
L
F
V
R
-
F
A
D
-
G
R
A
A
R
A
A
G
F
E
A
L
----
F
E
T
H
I
H
P
L
L
H
A
M--
A
D
-
G
P
E
-
L
L
A
Y
R
A
V
L
Q
S
--
V
------
V
A
G
D
R
H
A
I
Y
R
G
A
E
E
I
R
------
S
F
L
R
R
P
V
-----
E
L
P
E
R
E
T
--------
V
T
V
E
N
H
V
M
V
P
E
D
---------------------
K
H
A
A
W
E
P
Q
-----------
V
A
I
L
L
Q
V
A
---
Q
D
-
T
F
-
E
P
Q
D
E
P
S
GVG
L
P
G
A
RDNR
Y
Y
R
K
A
L
S
T
E
I
L
R
N
A
--
H
A
D
-----------
G
G
L
R
A
Y
----------
I
M
H
G
V
W
--------
E
S
V
W
--
D
H
E
N
S
-
H
L
D
P
R
F
--------
L
A
A
A
G
P
-
V
-
G
--------------
A
----
A
A
V
V
G
P
V
E
P
--------
F
Y
L
-
T
R
R
L
V
V
A
----
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
48.02
15%
-21
- C6 -
4DVG
-
?
B:
[8-312]
--------------------------------------------------------------------
E
V
V
Q
Q
K
F
A
I
V
A
K
E
M
KID
N
---
P
E
L
I
T
I
P
N
Q
W
-
K
L
V
Q
E
Y
--
E
K
K
Q
K
K
D
I
R
I
Q
L
N
A
Q
K
T
---------------
G
N
W
-
R
N
-
A
I
T
D
P
K
Y
L
A
D
L
L
K
T
RDD
M
D
L
L
N
E
M
V
V
V
F
R
S
S
S
V
-
S
F
I
K
T
-
F
-----------------
V
S
V
G
G
L
A
N
L
M
A
I
Y
K
----------
K
K
I
E
A
E
N
S
N
T
A
-------
I
D
E
E
R
K
C
C
E
V
L
R
---
Y
V
F
A
E
E
D
A
T
V
A
L
I
E
I
D
G
G
V
----
E
--
L
L
L
K
G
M
N
S
K
R
I
T
-----
P
D
N
Q
L
D
I
L
-----
L
E
I
T
L
T
S
S
M
V
E
H
P
S
Q
E
------------------------
G
L
Y
L
G
--
G
D
V
C
V
M
N
A
F
S
N
L
V
-
S
E
G
V
D
M
K
----------
K
F
L
-
S
F
F
S
L
F
S
-
K
--------
S
K
S
E
K
F
K
H
A
S
-----------
L
V
L
I
N
N
L
I
D
Q
P
E
----------
L
-
E
H
R
M
D
V
R
N
S
F
I
-
E
I
G
L
V
-------
N
-
E
L
E
N
M
K
N
T
E
----------------
W
M
K
I
D
-
K
I
--
K
D
S
I
N
-
D
F
F
D
--
S
W
E
E
D
K
K
E
V
E
S
R
--
F
D
------
D
-
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
46.85
11%
-13
- C4 -
1LRR
2
SEQA_ECOLI
A:
[28-123]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
Y
A
E
-
Q
K
R
A
-
V
N
R
-----
F
M
L
L
------
L
S
T
L
Y
--------------
S
L
D
A
Q
A
F
A
E
A
T
E
-----
S
LH
G
R
T
R
V
----
Y
F
A
A
D
E
-
Q
T
L
L
--
K
N
-------
G
N
Q
-
T
K
P
-------
K
H
---------
V
P
G
-----
T
P
Y
W
V
I
T
N
T
N
T
G
R
K
C
S
M
I
E
H
I
M
Q
S
M
Q
--------
F
P
A
E
L
I
E
K
V
----------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
44.55
10%
-20
- C4 -
3FMT
2
SEQA_ECOLI
A:
[60-154]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
A
E
-
Q
K
R
A
-
V
N
R
-----
F
M
L
L
------
L
S
T
L
Y
--------------
S
L
D
A
Q
A
F
A
E
A
T
E
-----
S
LH
G
R
T
R
V
----
Y
F
A
A
D
E
-
Q
T
L
L
--
K
N
-------
G
N
Q
-
T
K
P
-------
K
H
---------
V
P
G
-----
T
P
Y
W
V
I
T
N
T
N
T
G
R
K
C
S
M
I
E
H
I
M
Q
S
M
Q
--------
F
P
A
E
L
I
E
K
V
----------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
44.00
10%
-21
* C4 *
1J3E
2
SEQA_ECOLI
A:
[14-108]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
A
E
-
Q
K
R
A
-
V
N
R
-----
F
M
L
L
------
L
S
T
L
Y
--------------
S
L
D
A
Q
A
F
A
E
A
T
E
-----
S
LH
G
R
T
R
V
----
Y
F
A
A
D
E
-
Q
T
L
L
--
K
N
-------
G
N
-
Q
T
K
P
-------
K
H
---------
V
P
G
-----
T
P
Y
W
V
I
T
N
T
N
T
G
R
K
C
S
M
I
E
H
I
M
Q
S
M
Q
--------
F
P
A
E
L
I
E
K
V
----------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
42.81
19%
63
- C8 -
2BUQ
2
PCXA_ACIAD
A:
[8-107]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
E
T
P
S
Q
T
G
G
P
Y
V
H
I
G
L
----
L
P
K
Q
A
N
I
E
V
F
E
H
N
L
D
N
N
L
V
Q
----
D
-
N
T
Q
G
Q
R
I
R
L
-
E
G
Q
V
-
F
D
G
L
G
L
P
L
R
D
V
L
------
I
E
I
W
Q
--------------
A
D
T
N
G
V
Y
P
S
Q
A
D
-----
T
--
Q
G
-
K
Q
VDPN
F
L
G
W
G
R
-
T
G
A
D
--
F
G
-------
T
G
F
W
S
F
N
-------
T
I
---------
K
P
G
-----
A
V
P
G
R
K
G
S
T
Q
A
P
H
I
S
L
I
I
F
A
R
G
I
N
I
G
--------
L
H
T
R
V
Y
F
D
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
42.70
19%
59
- C8 -
2BUY
2
PCXA_ACIAD
A:
[8-107]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
E
T
P
S
Q
T
G
G
P
Y
V
H
I
G
L
----
L
P
K
Q
A
N
I
E
V
F
E
H
N
L
D
N
N
L
V
Q
----
D
-
N
T
Q
G
Q
R
I
R
L
-
E
G
Q
V
-
F
D
G
L
G
L
P
L
R
D
V
L
------
I
E
I
W
Q
--------------
A
D
T
N
G
V
Y
P
S
Q
A
D
-----
T
--
Q
G
-
K
Q
VDPN
F
L
G
W
G
R
-
T
G
A
D
--
F
G
-------
T
G
F
W
S
F
N
-------
T
I
---------
K
P
G
-----
A
V
P
G
R
K
G
S
T
Q
A
P
H
I
S
L
I
I
F
A
H
G
I
N
I
G
--------
L
H
T
R
V
Y
F
D
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
42.67
29%
78
- C4 -
1M2V
-
SEC24_YEAST
B:
[716-805]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
K
----
H
M
A
F
R
S
G
I
V
P
S
-
D
H
R
A
-
S
A
L
N
--
N
L
E
S
L
P
------
L
K
Y
L
I
--------------
K
N
I
Y
P
D
V
Y
S
L
H
D
-----
M
--
A
D
-
E
A
----
G
L
P
----------------------
G
T
I
V
-------
L
P
QPINATSSL
F
E
R
-----
Y
G
L
Y
L
I
D
N
G
N
E
L
F
L
W
M
G
G
D
A
V
P
A
L
V
F
--------
F
N
Q
R
V
R
N
I
I
----------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
42.63
19%
53
- C8 -
2BUM
1
PCXA_ACIAD
A:
[8-107]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
E
T
P
S
Q
T
G
G
P
Y
V
H
I
G
L
----
L
P
K
Q
A
N
I
E
V
F
E
H
N
L
D
N
N
L
V
Q
----
D
-
N
T
Q
G
Q
R
I
R
L
-
E
G
Q
V
-
F
D
G
L
G
L
P
L
R
D
V
L
------
I
E
I
W
Q
--------------
A
D
T
N
G
V
Y
P
S
Q
A
D
-----
T
--
Q
G
-
K
Q
VDPN
F
L
G
W
G
R
-
T
G
A
D
--
F
G
-------
T
G
F
W
S
F
N
-------
T
I
---------
K
P
G
-----
A
V
P
G
R
K
G
S
T
Q
A
P
H
I
S
L
I
I
F
A
R
G
I
N
I
G
--------
L
H
T
R
V
Y
F
D
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
42.29
19%
63
- C8 -
2BUR
1
PCXA_ACIAD
A:
[8-107]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
E
T
P
S
Q
T
G
G
P
Y
V
H
I
G
L
----
L
P
K
Q
A
N
I
E
V
F
E
H
N
L
D
N
N
L
V
Q
----
D
-
N
T
Q
G
Q
R
I
R
L
-
E
G
Q
V
-
F
D
G
L
G
L
P
L
R
D
V
L
------
I
E
I
W
Q
--------------
A
D
T
N
G
V
Y
P
S
Q
A
D
-----
T
--
Q
G
-
K
Q
VDPN
F
L
G
W
G
R
-
T
G
A
D
--
F
G
-------
T
G
F
W
S
F
N
-------
T
I
---------
K
P
G
-----
A
V
P
G
R
K
G
S
T
Q
A
P
H
I
S
L
I
I
F
A
R
G
I
N
I
G
--------
L
H
T
R
V
Y
F
D
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
42.21
19%
61
- C8 -
2BUT
1
PCXA_ACIAD
A:
[8-107]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
E
T
P
S
Q
T
G
G
P
Y
V
H
I
G
L
----
L
P
K
Q
A
N
I
E
V
F
E
H
N
L
D
N
N
L
V
Q
----
D
-
N
T
Q
G
Q
R
I
R
L
-
E
G
Q
V
-
F
D
G
L
G
L
P
L
R
D
V
L
------
I
E
I
W
Q
--------------
A
D
T
N
G
V
Y
P
S
Q
A
D
-----
T
--
Q
G
-
K
Q
VDPN
F
L
G
W
G
R
-
T
G
A
D
--
F
G
-------
T
G
F
W
S
F
N
-------
T
I
---------
K
P
G
-----
A
V
P
G
R
K
G
S
T
Q
A
P
H
I
S
L
I
I
F
A
R
G
I
N
I
G
--------
L
H
T
R
V
Y
F
D
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
42.20
19%
64
- C8 -
1EO9
1
PCXA_ACIAD
A:
[8-107]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
E
T
P
S
Q
T
G
G
P
Y
V
H
I
G
L
----
L
P
K
Q
A
N
I
E
V
F
E
H
N
L
D
N
N
L
V
Q
----
D
-
N
T
Q
G
Q
R
I
R
L
-
E
G
Q
V
-
F
D
G
L
S
L
P
L
R
D
V
L
------
I
E
I
W
Q
--------------
A
D
T
N
G
V
Y
P
S
Q
A
D
-----
T
--
Q
G
-
K
Q
VDPN
F
L
G
W
G
R
-
T
G
A
D
--
F
G
-------
T
G
F
W
S
F
N
-------
T
I
---------
K
P
G
-----
A
V
P
G
R
K
G
S
T
Q
A
P
H
I
S
L
I
I
F
A
R
G
I
N
I
G
--------
L
H
T
R
V
Y
F
D
D
----------------------------------------------------------------------------------------------------------------------------------------------------------