@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0931: (2015-12-19 )
MNNSVIIIESPNKVAKIREITGAKVFATIGHFMQLKSYDENNGFKPTFDYDQEKKKHIFEMIEACKNKKVYIATDPDREGYAIGYMFYQKIKNVASSIYRAEFFEITPSGINKGLQNALLFENTNRQMYQSALARRVADMLLGFTLSPYLGKALGQMKGSSAGRVQTPCLKLIVDRDREIEKFKALPENEKVSYQIQAKINDSANREVTIKHCDEKGEEIKFNDKEEALKLFESLKDNKACLLKDLKNSVVETKPKKPFITSTLLEKASSMLGLSISEVQSLAQNLFEAGLITYIRTDAESLSVEFLDETESFYAPIYKDLYLKREYKAGKQSQAEAHEAIRITHPHTTEDLESIVYNANITNQDALKLYQLIFERTIESQGKNAIYDKQDLLFKIKNEYFKCSVKGLKSAGFLAMFSKKELENDESNDDKDNKEKEQNAQFNLKIDDVLSLNDLVLSTIKRNAPSAYKEADFVKLLENKGIGRPSTYASYLPTLVKREYISISQDKKHIITPTHKGKRVVEVFENAYQFIIDLTYTKQMEEVLDEIVENKSSYVDFISNLNSKCPKIEKLERNDDEIKPSSEGQITYIENILRDLQLNLSEEFKNYKEDNRVAKAFLDRYIKEHEFFKKNNKKASSSNNDENRPATPKQISFAEILAKKHNVKLPKGFKYSMKVCGDFINEYHKK
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20--------------------..--.---------------------.--.....30....----.----.----..----40.------------.------...-...---50.--.------......60..-..-.--..--.70........80........90...---.....100.......110....--...120.......130.......140.......150.....---..160.......170.......180.......190.......200.......210....------...220.......230.......240.......250.......260.......270.......280......--------.--------290.......300.......310.......---320-----.--..---...--.330.......340...-....350...-----....360----.--......370.......380.......390.......--400......--.----410.......420.......430.......440.......450.......460.......470......-----------------.480.......490.......500.......510.......520.......530.......540.......550..---..-...560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNN
S
V
I
I
I
ESPN
K
V
A
K
I
R
E
I---------------------TG--A---------------------
K
--
V
F
A
T
I
G
H
F
M
Q
L
----K----S----YD----ENN------------G------FKP-TFD---
Y
D
Q
--
E
------
K
K
K
H
I
F
E
M
I
E
-
A
C-K--N
K
--
K
V
Y
I
A
TDPDREGY
A
I
G
Y
M
F
Y
Q
K
I
K
N
V
---
A
S
S
I
Y
R
A
E
F
F
E
I
T
P
S
G
I
N
K
G
L
Q
--
N
A
L
L
FENT
N
R
Q
M
Y
Q
S
A
L
A
R
R
V
A
D
M
L
L
GFTL
S
P
Y
L
G
K
A
L
G
Q
M---KGSSAGRVQ
T
P
C
L
K
L
I
VDRDR
E
I
E
K
F
KALPENE
K
V
S
Y
Q
I
Q
A
K
INDSAN
R
E
V
T
I
K
HCDEK------G
E
E
I
KFN
D
K
E
E
A
L
K
L
F
E
S
LKD
N
K
A
C
L
L
K
D
L
K
N
S
V
VETKPKKP
F
I
T
S
T
L
L
E
K
A
S
S
M
LGL
S
I
S
E
V
Q
S
L
A
Q
N
L
F
E
--------
A
--------
G
L
I
T
Y
I
RTDAES
L
S
V
E
F
LDE
T
E
S
F
Y
A
P
I
Y
K
---
D
L
Y
-----
L
--
K
R
---
E
YK--AGKQSQAEAH
E
A
I
R
ITH-PH
T
T
E
D
L
E
S
I
-----
V
YNANIT----
N
--
Q
D
A
L
K
L
Y
Q
L
I
F
E
R
T
I
E
SQGKNAIYD
K
Q
D
L
L
F
K
I
K
N
E
--
Y
F
K
C
SVKGL--K----SA
G
F
L
A
M
F
S
K
K
ELENDESNDDKDN
K
E
K
EQN
A
Q
F
N
L
K
IDDVL
S
L
N
D
L
V
L
S
T
I
KRNAPSAY
K
E
A
D
F
V
K
L
L
E
-----------------NKGIGR
P
S
T
Y
A
S
Y
L
P
T
L
V
K
R
E
Y
ISISQDK
K
H
I
ITPTHKG
K
R
V
V
E
V
F
E
N
A
Y
Q
F
I
IDL
T
Y
T
K
Q
M
E
E
V
L
D
E
I
V
EN
K
S
S
Y
---
V
D
-
F
I
S
N
LNSKCP
K
I
E
K
LERNDDEIKPSSEGQ
I
T
Y
I
E
N
I
L
R
D
L
Q
L
N
L
S
E
E
F
K
N
Y
K
E
D
N
R
V
A
K
A
F
L
D
R
Y
I
K
E
H
E
F
F
K
KNNKKASSSNNDENRPATPKQ
I
S
F
A
E
I
L
A
K
KHNVKLPKG
F
K
Y
S
M
K
V
C
G
D
F
I
N
E
Y
HKK
8
PsiBlast_PDB
87.81
27%
-65
- C3 -
1CY4
4
TOP1_ECOLI
A:
[4-582]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
---------------------
L
G
--
S
---------------------
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P
T---------------------DER
G
A
L
V
N
R
M
--
G
------
V
D
P
-
W
H
N
---
W
E
A
--
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
-
K
--
A
D
--
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
-----
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
-----
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
--
V
P
E
E
---
F
W
E
V
D
A
S
T
T
T
P
S
G
E
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
-
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
--------
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
---
K
K
Y
-----
L
--
P
E
---
S
P
N
QY
A
--------
H
E
A
I
R
P
S
-------
D
V
N
V
M
-----
A
E
S
L
K
D
M
----
E
--
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
F
--
R
L
K
A
R
G
R
I
L
--
R
----
F
D
G
W
T
K
V
M
P
A
L
-------
I
L
P
A
V
N
K
------------
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
---
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
V
L
T
S
----------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
87.50
27%
-61
- C3 -
1CY6
4
TOP1_ECOLI
A:
[4-582]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
---------------------
L
G
--
S
---------------------
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
PT---------------------DER
G
A
L
V
N
R
M
--
G
------
V
D
P
-
W
H
N
---
W
E
A
--
H
Y
E
VLPG
K
E
K
V
V
S
E
L
K
Q
L
A
E
-
K
--
A
D
--
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
-----
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
-----
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
--
V
P
E
E
---
F
W
E
V
D
A
S
T
T
T
P
S
G
E
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
-
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
--------
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
---
K
K
Y
-----
L
--
P
E
---
S
P
N
Q
Y
A
-------
A
H
E
A
I
R
P
S
-------
D
V
N
V
M
-----
A
E
S
L
K
D
M
----
E
--
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
F
--
R
L
K
A
R
G
R
I
L
--
R
----
F
D
G
W
T
K
V
M
P
A
L
R
---
E
D
R
I
L
P
A
V
N
K
------------
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
---
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
V
L
T
-----------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
87.07
27%
-61
- C3 -
3PWT
3
TOP1_ECOLI
A:
[2-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
---------------------
L
G
--
S
---------------------
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
PT---------------------DER
G
A
L
V
N
R
M
--
G
------
V
D
P
-
W
H
N
---
W
E
A
--
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
-
K
--
A
D
--
H
I
Y
L
A
T
N
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
-----
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
-----
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
--
V
P
E
E
---
F
W
E
V
D
A
S
T
T
T
P
S
G
E
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
-
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
--------
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
---
K
K
Y
-----
L
--
P
E
---
S
P
N
Q
Y
A
-------
A
H
E
A
I
R
P
S
-------
D
V
N
V
M
-----
A
E
S
L
K
D
M
----
E
--
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
F
--
R
L
K
A
R
G
R
I
L
--
R
----
F
D
G
W
T
K
V
M
P
A
L
R
---
E
D
R
I
L
P
A
V
N
K
------------
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
---
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
V
L
T
-----------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
87.04
27%
-61
- C3 -
1MW9
9
TOP1_ECOLI
X:
[2-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
---------------------
L
G
--
S
---------------------
D
YV
V
K
S
S
V
G
H
I
R
D
L
PT---------------------ERGALVNRM---
G
------
V
D
P
-
W
H
N
---
W
E
A
--
H
YEVLPG
K
E
K
V
V
S
E
L
K
Q
L
A
E
-
K
--
A
D
--
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
KP
G
E
L
N
I
D
R
V
N
A
Q
Q
-----
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
-----
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
--
V
P
E
E
---
F
W
E
V
D
A
S
T
T
T
P
S
G
E
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
-
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
--------
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
---
K
K
Y
-----
L
--
P
E
---
S
P
N
QY
A
--------
R
E
A
I
R
P
S
-------
D
V
N
V
M
-----
A
E
S
L
K
D
M
----
E
--
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
F
--
R
L
K
A
R
G
R
I
L
--
R
----
F
D
G
W
T
K
V
M
P
A
L
----
E
D
R
I
L
P
A
V
N
K
------------
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
---
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
KAV
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
--------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
86.95
27%
-68
- C3 -
3PX7
3
TOP1_ECOLI
A:
[2-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
---------------------
L
G
--
S
---------------------
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P----------------------DER
G
A
L
V
N
R
M
--
G
------
V
D
P
-
W
H
N
---
W
E
A
--
H
Y
E
V
L
PG
K
E
K
V
V
S
E
L
K
Q
L
A
E
-
K
--
A
D
--
H
I
Y
L
A
T
N
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
-----
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
-----
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
--
V
P
E
E
---
F
W
E
V
D
A
S
T
T
T
P
S
G
E
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
-
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
--------
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
---
K
K
Y
-----
L
--
P
E
---
S
P
N
QY
A
--------
H
E
A
I
R
P
S
-------
D
V
N
V
M
-----
A
E
S
L
K
D
M
----
E
--
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
F
--
R
L
K
A
R
G
R
I
L
--
R
----
F
D
G
W
T
K
V
M
P
A
L
R
------
I
L
P
A
V
N
K
------------
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
---
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
----------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
86.78
27%
-63
- C3 -
1ECL
-
TOP1_ECOLI
A:
[2-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
---------------------
L
G
--
S
---------------------
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P----------------------DER
G
A
L
V
N
R
M
--
G
------
V
D
P
-
W
H
N
---
W
E
A
--
H
Y
E
V
L
PG
K
E
K
V
V
S
E
L
K
Q
L
A
E
-
K
--
A
D
--
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
-----
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
-----
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
--
V
P
E
E
---
F
W
E
V
D
A
S
T
T
T
P
S
G
E
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
-
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
--------
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
---
K
K
Y
-----
L
--
P
E
S
P
N
Q
Y
A
-----------
H
E
A
I
R
P
S
-------
D
V
N
V
M
-----
A
E
S
L
K
D
M
----
E
--
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
F
--
R
L
K
A
R
G
R
I
L
--
R
----
F
D
G
W
T
K
V
M
P
A
L
R
------
I
L
P
A
V
N
K
------------
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
---
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
----------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
86.73
27%
-61
- C3 -
1CY8
3
TOP1_ECOLI
A:
[4-582]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
---------------------
L
G
--
S
---------------------
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P----------------------DER
G
A
L
V
N
R
M
--
G
------
V
D
P
-
W
H
N
---
W
E
A
--
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
-
K
--
A
D
--
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
-----
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
-----
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
--
V
P
E
E
---
F
W
E
V
D
A
S
T
T
T
P
S
G
E
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
-
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
--------
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
---
K
K
Y
-----
L
--
P
E
---
S
P
N
Q
Y
A
--------
H
E
A
I
R
P
S
-------
D
V
N
V
M
-----
A
E
S
L
K
D
M
----
E
--
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
F
--
R
L
K
A
R
G
R
I
L
--
R
----
F
D
G
W
T
K
V
M
P
A
L
R
K
G
D
E
D
R
I
L
P
A
V
N
K
------------
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
---
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
V
L
T
-----------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.44
27%
-63
- C3 -
1CY1
4
TOP1_ECOLI
A:
[4-582]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
---------------------
L
G
--
S
---------------------
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P----------------------R
G
A
L
V
N
R
M
----
G
------
V
D
P
-
W
H
N
---
W
E
A
--
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
-
K
--
A
D
--
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
-----
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
-----
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
--
V
P
E
E
---
F
W
E
V
D
A
S
T
T
T
P
S
G
E
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
-
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
--------
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
---
K
K
Y
-----
L
--
P
E
---
S
P
N
QY
A
------
E
A
H
E
A
I
R
P
S
-------
D
V
N
V
M
-----
A
E
S
L
K
D
M
----
E
--
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
F
--
R
L
K
A
R
G
R
I
L
--
R
----
F
D
G
W
T
K
V
M
P
A
L
-------
I
L
P
A
V
N
K
------------
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
---
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
V
L
T
S
----------------------------------------------------------------------------------------------------
22
HHSearch
86.40
28%
-65
- C3 -
1MW9
9
TOP1_ECOLI
X:
[2-579]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
---------------------
L
G
SD
Y
---------------------
V
--
V
K
S
S
V
G
H
I
R
D
L
----
P
----
T
-------------ERGALVNRMGVD
P
------
W
H
N
W
E
A
H
---
Y
E
V
LP
G
------
K
E
K
V
V
S
E
L
K
Q
-
L
A
E
K
--
A
D
--
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
--
K
P
G
---
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
-----
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
-----
F
W
E
V
D
A
S
T
T
T
P
S
G
E
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
--------
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
---
K
K
Y
-----
L
PE
S
P
---
N
Q
Y
--
A
--------
R
E
A
I
R
P
S
D
-
V
N
V
M
A
E
S
L
-----------
K
D
M
----
E
--
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
F
--
R
L
K
A
R
G
R
I
L
--
R
----
F
D
G
W
T
K
V
M
P
A
L
----------------
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
--
N
-
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
---
K
A
-
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
----------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.11
27%
-62
- C3 -
1CY2
3
TOP1_ECOLI
A:
[4-582]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
---------------------
L
G
--
S
---------------------
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P----------------------DER
G
A
L
V
N
R
M
--
G
------
V
D
P
-
W
H
N
---
W
E
A
--
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
-
K
--
A
D
--
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
-----
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
-----
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
--
V
P
E
E
---
F
W
E
V
D
A
S
T
T
T
P
S
G
E
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
-
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
--------
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
---
K
K
Y
-----
L
--
P
E
---
S
P
N
Q
Y
A
-------
A
H
E
A
I
R
P
S
-------
D
V
N
V
M
-----
A
E
S
L
K
D
M
----
E
--
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
F
--
R
L
K
A
R
G
R
I
L
--
R
----
F
D
G
W
T
K
V
M
P
A
L
R
------
I
L
P
A
V
N
K
------------
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
---
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
V
L
------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
85.32
27%
-61
- C3 -
1MW8
7
TOP1_ECOLI
X:
[2-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
---------------------
L
G
--
S
---------------------
D
YV
V
K
S
S
V
G
H
I
R
D
L
PTSG-------------------DERGALVNRM--
G
------
V
D
P
-
W
H
N
---
W
E
A
--
H
YEVLPG
K
E
K
V
V
S
E
L
K
Q
L
A
E
-
K
--
A
D
--
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
KP
G
E
L
N
I
D
R
V
N
A
Q
Q
-----
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
-----
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
--
V
P
E
E
---
F
W
E
V
D
A
S
T
T
T
P
S
G
E
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
-
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
--------
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
---
K
K
Y
-----
L
--
P
E
---
S
P
N
QY
A
S
-----
E
A
R
E
A
I
R
P
S
-------
D
V
N
V
M
-----
A
E
S
L
K
D
M
----
E
--
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
F
--
R
L
K
A
R
G
R
I
L
--
R
----
F
D
G
W
T
K
V
M
P
A
-----
E
D
R
I
L
P
A
V
N
K
------------
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
---
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
KAV
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
--------------------------------------------------------------------------------------------------------
43
Fugue
83.88
29%
-50
- C3 -
2GAI
-
TOP1_THEMA
A:
[7-601]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
---------------------
L
G
--
N
E
Y
-------------------
E
--
V
F
A
S
M
G
H
I
I
D
L
----
P
----
K
SKFG
V
D
----
L
E
K
------------
D
------
F
E
P
-
E
F
A
---
V
I
K
--
G
------
K
E
K
V
V
E
K
L
K
D
-
L
A
-
K
--
K
G
--
E
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
T
----
L
G
R
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
--
N
P
---
R
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
K
-----
S
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
-----
P
K
K
Y
H
R
I
T
V
N
F
D
G
-----
L
T
A
E
I
D
V
K
E
------
K
K
F
F
D
A
E
T
L
K
E
I
Q
S
-------
I
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
KD
G
H
I
--------
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
K
E
E
A
R
N
L
I
T
E
V
F
--------------------------
G
E
E
Y
V
-
G
A
H
E
A
I
R
P
T
N
V
F
M
T
P
E
E
A
G
K
Y
-----
L
----------
N
--
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K
D
G
K
Y
R
F
K
G
T
V
L
K
K
--
I
----
F
D
G
Y
E
K
V
W
----------------
K
T
E
R
N
T
G
E
F
P
F
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
-----------------
R
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
K
K
I
---
R
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
Y
S
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
---
K
I
-
V
L
R
E
F
Y
E
S
F
S
S
-----
V
F
D
R
N
D
R
I
V
V
D
F
P
T
N
Q
K
C
S
C
G
K
E
M
R
L
S
F
G
---------------------
K
Y
G
F
Y
L
K
C
E
C
G
K
T
R
S
V
K
N
D
E
I
A
V
I
D
D
G
K
I
F
L
---------------------------------
7
PsiBlast_PDB
83.55
27%
-60
- C3 -
1CY0
1
TOP1_ECOLI
A:
[4-574]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
---------------------
L
G
--
S
---------------------
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P----------------------A
L
V
N
R
M
------
G
------
V
D
P
-
W
H
N
---
W
E
A
--
H
Y
E
V
L
PG
K
E
K
V
V
S
E
L
K
Q
L
A
E
-
K
--
A
D
--
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
-----
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
-----
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
--
V
P
E
E
---
F
W
E
V
D
A
S
T
T
T
P
S
G
E
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
-
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
--------
A
--------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
---
K
K
Y
-----
L
--
P
E
---
S
P
N
Q
Y
A
S
K
E
N
S
Q
E
A
H
E
A
I
R
P
S
-------
D
V
N
V
M
-----
A
E
S
L
K
D
M
----
E
--
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
F
--
R
L
K
A
R
G
R
I
L
--
R
----
F
D
G
W
T
K
V
M
----------
I
L
P
A
V
N
K
------------
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
---
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
----------------------------------------------------------------------------------------------------------------------------
24
HHSearch
81.70
29%
-65
- C3 -
2GAI
-
TOP1_THEMA
A:
[7-545]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
---------------------
L
G
NE
Y
---------------------
E
--
V
F
A
S
M
G
H
I
I
D
L
----
P
----
K
----
S
K
FGVD
L
E
K
------------
D
------
F
E
P
-
E
F
A
---
V
I
K
--
G
------
K
E
K
V
V
E
K
L
K
D
-
L
A
-
K
--
K
G
--
E
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
T
----
L
G
R
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
--
N
P
R
---
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
K
-----
S
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
-----
Y
H
R
I
T
V
N
F
D
G
L
T
A
-
E
I
--
D
V
K
-----------
E
K
K
F
F
D
A
E
T
L
K
E
I
Q
S
-
I
---
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
--------
G
V
E
T
KD
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
K
E
E
A
R
N
L
I
T
E
V
F
G
---
E
E
Y
-----
V
--
G
-----------------
A
H
E
A
I
R
P
T
N
-
V
F
M
T
P
E
E
A
----------
G
K
Y
L
----
N
--
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K
D
G
--
K
Y
R
F
K
G
T
V
L
K
K
I
----
F
D
G
Y
E
K
V
W
K
T
E
R
N
----------------
T
G
E
F
P
F
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
-----------------
R
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
K
K
I
--
R
-
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
Y
S
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
---
K
I
-
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
I
V
V
D
F
P
T
N
Q
K
C
S
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
E
C
G
K
T
R
S
V
K
N
D
E
I
A
V
I
D
D
G
K
I
F
L
-----------------------------------------------------------
46
Fugue
80.40
26%
-29
- C3 -
4DDU
3
RGYR_THEMA
A:
[2-1103]
AVN
S
K
Y
H
HSCINCGGLNT
D
E
R
N
E
R
GLPCEVCLPEDSPSD
I
Y
R
A
L
L
E
R
KTLKE
Y
R
F
Y
H
E
F
W
N
E
Y
E
D
F
R
S
F
F
K
K
K
F
G
K
D
L
T
G
Y
Q
R
L
W
A
K
R
I
V
Q
G
K
S
F
T
MVAPTGVG
K
T
T
F
G
M
M
T
A
L
W
L
A
R
K
G
K
K
S
A
L
V
F
PT
V
T
L
V
K
Q
T
L
E
R
L
Q
K
L
ADEK
V
K
I
F
G
F
Y
SSMK
K
E
E
K
E
K
F
E
K
S
F
E
EDDYH
I
L
V
F
S
T
Q
F
V
S
K
N
R
E
K
L
S
Q
KRFD
F
V
F
V
DD
V
D
A
V
L
KA
S
R
N
I
D
T
L
L
M
M
VGIP
E
E
I
I
R
K
A
F
S
T
I
K
Q
G
K
I
Y
E
R
PKN
L
K
P
G
I
L
V
V
S
S
ATAKPRGIRP
L
L
F
R
D
L
LNFTVGRLVSVARN
I
T
H
V
R
I
SSRS
K
E
K
L
V
E
L
L
E
I
F
RDG
I
L
I
F
A
QT
E
E
E
G
K
E
L
Y
E
Y
L
K
R
F
KFNVGETWSEF
E
K
N
F
E
D
F
K
V
GKIN
I
L
I
G
V
Q
A
Y
Y
G
K
L
TRGVDLPERIK
Y
V
I
F
WG
T
P
S
M
R
F
S
LELDKAP
R
F
V
L
A
R
V
L
K
E
M
GLIK
A
Q
E
N
P
D
V
E
E
L
R
K
I
A
KEHLT
Q
K
E
F
V
E
K
V
K
E
M
FRGVVVKDEDL
E
L
I
I
P
D
V
Y
T
Y
I
Q
A
S
G
RSSRILNGVL
V
K
G
V
S
V
I
F
E
ED
E
E
I
F
E
S
L
K
T
R
L
L
L
IAE
E
E
I
I
E
EAEAN
W
K
E
L
V
H
E
V
E
E
S
R
R
R
S
E
R
E
L
T
D
T
S
R
S
L
L
I
I
V
E
S
P
T
K
A
E
T
L
S
R
F
L
GRA
S
S
R
K
E
RN
I
I
V
H
E
A
V
T
GE
G
V
I
L
F
T
A
TRGHVYDLVTKGGIHG
V
E
E
E
N
G
K
F
V
P
V
Y
N
S
L
K
R
C
R
-------------------------------------------------------------
D
C
G
Y
----
Q
----
F
----
T
E
----
D
R
D
------------
E
------
C
P
V
-
C
S
S
---
K
N
I
--
D
------
D
K
T
E
T
L
R
A
L
R
-
E
I
-
S
L
E
A
D
--
E
I
L
V
A
T
D
P
D
V
E
G
E
K
I
S
W
D
V
T
Q
Y
L
L
P
S
---
T
R
S
L
R
R
I
E
M
H
E
I
T
R
Y
G
F
K
K
A
R
E
--
S
V
---
R
F
V
D
F
N
L
V
K
A
Q
I
V
R
R
V
Q
D
R
W
I
G
F
E
L
S
G
K
L
Q
K
R
F
G
R
----
S
N
L
S
A
G
R
V
Q
S
T
V
L
G
W
I
V
E
R
E
E
E
Y
K
K
----
S
E
K
D
F
T
L
L
V
L
E
----
N
G
V
N
L
E
V
E
G
K
-----------------------------
I
A
D
D
-
V
V
T
V
V
E
L
Q
E
A
E
E
E
K
N
P
L
P
P
Y
T
T
S
S
A
L
S
E
I
S
Q
K
L
R
L
G
V
Q
E
V
M
D
I
L
Q
D
L
F
E
--------
K
--------
G
F
I
T
Y
H
R
T
D
S
T
R
I
S
L
E
G
Q
N
V
A
R
T
Y
L
R
K
I
G
K
--------------
E
D
---
I
F
M
--
G
R
S
W
S
T
E
G
A
H
E
A
I
R
P
V
K
-
P
I
D
A
R
E
L
E
E
M
-----
I
E
E
G
L
I
A
----
D
LT
K
K
H
L
R
V
Y
E
L
I
F
N
R
F
L
A
S
Q
S
A
A
---------
V
K
V
K
K
Q
--
I
V
T
V
D
V
D
G
----------
K
R
M
G
I
E
Q
I
V
E
I
L
R
D
G
W
N
L
F
V
P
L
T
V
S
P
R
F
E
H
R
T
Y
K
I
K
E
K
K
F
Y
--------
K
K
H
T
V
P
L
F
T
Q
A
S
I
V
E
E
M
K
-----------------
K
R
G
I
G
R
P
S
T
Y
A
K
I
V
E
V
L
F
R
R
G
Y
--
V
Y
E
D
K
Y
K
R
V
R
P
T
R
F
G
V
M
V
Y
S
Y
L
K
E
R
Y
E
K
Y
V
T
E
E
T
T
R
R
L
E
E
I
M
D
K
V
E
R
G
E
E
D
Y
---
Q
A
-
T
L
R
L
L
Y
E
E
I
K
S
L
M
E
E
-------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
78.97
30%
-58
- C3 -
2GAI
-
TOP1_THEMA
A:
[9-527]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
---------------------
L
G
NE
Y
---------------------
E
--
V
F
A
S
M
G
H
I
I
D
L
----
P
KSKF
G
----
V
D
----
L
E
K
------------
D
------
F
E
P
-
E
F
A
---
V
I
K
--
G
------
K
E
K
V
V
E
K
L
K
D
-
L
A
-
K
--
K
G
--
E
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
-
A
R
V
T
N
T
---
L
G
R
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
--
N
P
---
R
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
K
S
-----
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
--
V
P
---
K
K
Y
H
R
I
T
V
N
F
-
D
G
L
T
A
E
I
D
V
K
-------------
E
K
K
F
F
D
-
A
E
T
L
K
E
I
Q
S
I
D
E
---
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
--------
G
V
E
T
KD
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
K
E
E
A
R
N
L
I
T
E
V
F
G
---
E
E
Y
-----
V
G-------------------
A
H
E
A
I
R
P
T
N
-
V
F
M
T
P
E
-
E
A
G
-----
K
Y
----
L
----
N
--
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K
D
G
--
K
Y
R
----------------
F
K
G
T
V
L
K
K
I
F
D
G
Y
E
----
K
V
W
K
T
E
R
N
T
G
E
F
P
F
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
-----------------
R
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
---
K
K
I
R
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
Y
S
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
---
K
I
-
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
I
V
V
D
F
P
T
N
Q
K
C
S
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
E
C
G
K
T
R
S
V
K
N
D
E
I
A
V
I
D
D
G
K
I
F
L
-----------------------------------------------------------
49
Fugue
78.96
23%
-45
- C3 -
1GKU
-
RGYR_ARCFU
B:
[1-1054]
-------------------------------------------------------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAASLCLFPEDFLLKEFVEFFRKCVGEPRAIQKMWAKRILRKESFAATAPTGVGKTSFGLAMSLFLALKGKRCYVIFPTSLLVIQAAETIRKYAEKAGVGTENLIGYYHGRIPKREKENFMQNLRNFKIVITTTQFLSKHYRELGHFDFIFVDDVDAILKASKNVDKLLHLLGFHYDLKTKSWVGEARGCLMVSTATAKKGKKAELFRQLLNFDIGSSRITVRNVEDVAVNDESISTLSSILEKLGTGGIIYARTGEEAEEIYESLKNKFRIGIVTATKKGDYEKFVEGEIDHLIGTAHRGLDLPERIRFAVFVGCPSFRVTIEDIDSLSPQMVKLLAYLYRNVDEIERLLPAVERHIDEVREILKKVMGKERPQAKDVVVREGEVIFPDLRTYIQGSGRTSRLFAGGLTKGASFLLEDDSELLSAFIERAKLYDIEFKSIDEVDFEKLSRELDESRDRYRRRQEFDL
I
K
P
A
L
F
I
V
E
S
P
T
K
A
R
Q
I
S
R
F
FGKPSVKVLDGAVVYEIPMQK
Y
V
--
L
---------------------
M
--
V
T
A
S
I
G
H
V
V
D
L
----
I
----
T
----
N
R
----
G
F
H
------------
G
VLVNGR
F
V
P
-
V
Y
A
---
S
I
K
--
D
------
N
S
R
S
R
I
E
A
L
R
-
K
L
-
A
--
H
D
AE
F
V
I
V
G
T
D
P
D
T
E
G
E
K
I
A
W
D
L
K
N
L
L
S
G
----
C
G
A
V
K
R
A
E
F
H
E
V
T
R
R
A
I
L
E
A
L
E
--
S
L
---
R
D
V
D
E
N
L
V
K
A
Q
V
V
R
R
I
E
D
R
W
I
G
F
V
L
S
Q
K
L
W
E
R
F
N
N
----
R
N
L
S
A
G
R
A
Q
T
L
V
L
G
W
I
I
D
R
F
Q
E
S
R
E
R
R
K
I
A
I
V
R
D
F
D
L
V
L
E
H
D
------------------------------------------
E
E
E
F
D
L
T
I
K
L
V
E
E
R
E
E
L
R
T
P
L
P
P
Y
T
T
E
T
M
L
S
D
A
N
R
I
L
K
F
S
V
K
Q
T
M
Q
I
A
Q
E
L
F
E
--------
N
--------
G
L
I
T
Y
H
R
T
D
S
T
R
V
S
D
V
G
Q
R
I
A
K
E
Y
L
-------------------
G
D
---
D
F
V
--
G
R
E
W
G
E
S
G
A
H
E
C
I
R
P
T
R
-
P
L
T
R
D
D
V
Q
R
L
-----
I
Q
E
G
V
L
V
VEGL
R
--
W
E
H
F
A
L
Y
D
L
I
F
R
R
F
M
A
S
Q
C
R
P
F
K
V
V
V
K
K
Y
S
I
E
F
D
G
K
--
T
A
E
E
E
R
I
V
R
--
A
----
E
G
R
A
Y
E
L
Y
R
A
V
W
V
K
N
E
L
P
T
G
----------------------
T
F
R
V
K
A
E
V
K
S
V
P
K
V
L
P
F
T
Q
S
E
I
I
Q
M
M
K
-----------------
E
R
G
I
G
R
P
S
T
Y
A
T
I
V
D
R
L
F
M
R
N
Y
V
V
E
K
---
Y
G
R
M
I
P
T
K
L
G
I
D
V
F
R
F
L
V
R
R
Y
A
K
F
V
S
E
D
R
T
R
D
L
E
S
R
M
D
A
I
E
R
G
E
L
D
Y
---
L
K
-
A
L
E
D
M
Y
A
E
I
K
S
I
D
---------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.16
30%
-60
- C3 -
2GAJ
-
TOP1_THEMA
A:
[9-527]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
---------------------
L
G
NE
Y
---------------------
E
--
V
F
A
S
M
G
H
I
I
D
L
----
P
KSKF
G
----
V
D
----
L
E
K
------------
D
------
F
E
P
-
E
F
A
---
V
I
K
--
G
------
K
E
K
V
V
E
K
L
K
D
-
L
A
-
K
--
K
G
--
E
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
-
A
R
V
T
N
T
---
L
G
R
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
--
N
P
---
R
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
K
S
-----
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
--
V
P
---
K
K
Y
H
R
I
T
V
N
F
-
D
G
L
T
A
E
I
D
V
K
-------------
E
K
K
F
F
D
-
A
E
T
L
K
E
I
Q
S
I
D
E
---
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
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T
L
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Q
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A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
--------
G
V
E
T
KD
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
K
E
E
A
R
N
L
I
T
E
V
F
G
---
E
E
Y
-----
V
G-------------------
A
H
E
A
I
R
P
T
N
-
V
F
M
T
P
E
-
E
A
G
-----
K
Y
----
L
----
N
--
S
D
Q
K
K
L
Y
E
L
I
W
K
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F
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A
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M
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Q
Y
E
E
T
R
F
V
L
R
T
K
D
G
--
K
Y
R
----------------
F
K
G
T
V
L
K
K
I
F
D
G
Y
E
----
K
V
W
K
T
E
R
N
T
G
E
F
P
F
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
-----------------
R
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
---
K
K
I
R
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
Y
S
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
---
K
I
-
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
I
V
V
D
F
P
T
N
Q
K
C
S
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
E
C
G
K
T
R
S
V
K
N
D
E
I
A
V
I
D
D
G
K
I
F
L
-----------------------------------------------------------
23
HHSearch
76.75
22%
-53
* C3 *
1I7D
3
TOP3_ECOLI
A:
[1-607]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
---------------------
L
P
--
K
P
H
R
K
G
DG
F
I
E
C
G
NG
Q
------
V
--
V
T
W
C
I
G
H
L
L
E
Q
----
A
----
Q
----
P
D
----
A
Y
D
SRYARWNLADL-
P
------
I
V
P
E
K
W
Q
---
L
Q
P
--
R
PS----
V
T
K
Q
L
N
V
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K
R
-
F
L
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E
--
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--
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I
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A
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G
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L
L
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L
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C
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D
L
N
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A
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R
A
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D
--
R
L
R
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-
N
S
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F
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P
L
C
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S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
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A
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T
I
L
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R
N
A
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G
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L
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L
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F
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-----
F
F
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A
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A
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A
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L
A
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N
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A
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A
A
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F
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L
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A
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N
V
L
D
I
C
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K
L
Y
E
--------
T
H-------
K
L
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L
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A
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D
L
L
PQPVV
D
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D
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---
R
N
R
--
C
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A
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A
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--
A
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------------
N
L
----
T
--
E
N
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A
K
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Y
N
L
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A
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L
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A
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A
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--
K
F
V
A
K
A
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F
L
--
A
----
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A
G
W
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T
L
L
G
S
K
E
R
D
E
----------
E
N
D
G
T
P
L
P
V
V
A
K
G
D
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L
L
C
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K
G
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V
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A
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L
L
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A
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IARFVQD
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
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L
L
F
K
R
G
F
L
T
K
K
---
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
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K
Q
C
R
Y
---
Q
D
-
F
M
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P
L
V
G
T
L
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L
I
D
Q
A
K
R
T
P
V
R
Q
F
R
G
I
V
A
P
----------------------------------------------------------------------------------------------------
25
HHSearch
73.43
25%
-54
- C3 -
1GKU
-
RGYR_ARCFU
B:
[505-1053]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
A
L
F
I
V
E
S
P
T
K
A
R
Q
I
S
R
F
---------------------
F
G
--
K
PSVKVLDGAVVYEIPMQKYVL
M
--
V
T
A
S
I
G
H
V
V
D
L
----
I
----
T
----
N
R
----
G
F
H
GVLVNG------
R
------
F
V
P
-
V
Y
A
SIK--
D
--
N
------
S
R
S
R
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E
A
L
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L
A
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--
A
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--
F
V
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L
K
N
L
L
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----
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A
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A
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V
T
R
R
A
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L
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A
L
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--
S
L
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---
V
D
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N
L
V
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A
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V
R
R
I
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F
V
L
S
Q
K
L
W
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R
F
N
N
----
R
N
L
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A
G
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A
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T
L
V
L
G
W
I
I
D
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A
-----
I
V
R
-----------
D
F
D
L
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--------------
E
H
-
D
E
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-----------
F
D
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L
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L
P
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Y
T
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M
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A
N
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I
L
K
F
S
V
K
Q
T
M
Q
I
A
Q
E
L
F
E
--------
N
--------
G
L
I
T
Y
H
R
T
D
S
T
R
V
S
D
V
G
Q
R
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A
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E
Y
L
G
D
-------
D
F
-----
V
--
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--------
E
--
W
G
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A
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L
V
V
-
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----
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W
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A
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D
L
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R
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M
A
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C
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K
Y
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I
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F
D
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--
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A
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R
I
V
R
--
A
EGRA
Y
E
L
Y
R
A
V
W
V
K
-------------------
N
E
L
P
---
T
G
T
-
F
R
---
V
K
A
E
V
K
S
V
P
K
V
L
P
F
T
Q
S
E
I
I
Q
M
M
K
-----------------
E
R
G
I
G
R
P
S
T
Y
A
T
I
V
D
R
L
F
M
R
N
Y
V
V
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---
Y
G
R
M
I
P
T
K
L
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F
R
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R
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D
R
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R
D
L
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A
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R
G
E
L
D
Y
---
L
K
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A
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