@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1015: (2015-12-20 )
MKKFAYSEPCLDEEDKKAVLEVLNSKQLTQGKYSLLFEEALCEFLGVKHALAFNSATSALLTLYRNFSDFNADRNEIITTPISFVATANMLLESGYTPVFAEVKNDGNIDELALEKLITKKTKAIVSVDYAGKSVEIESIQRLCKKYSLSFLSDSSHALGSEYQNKKVGGFALASVFSFHAIKPITTAEGGAVVTNNSELYEKMKLFRSHGMLKKDFFEGEVKSVGYNFRLNEIQSALGLSQLKKAPLLRQKREEVALIYDEIFKDNPYFTPLHPLLKHQSSNHLYPILMHQKFFTCKKLILESLHKLGILVQVHYKPIYQYQLYQQLFNTAPLKSAEDFYSAEISLPCHANLDLESVQNIAHGVLKTFEGFNRMGFI
Atome Classification :
(21 SA)
......--..-----.10-........20.......-.-30.........40........50........-60..-......70........80.-.......-90........100....-..---.-.110--.........---120.......130.......140.......150.......160.......170.......180.....-..190.......200.......210.......-----220.......230.......240.......250.......260-..-.....--270...-..--...280.-......290--.-..-------------------.....300.-..-----..-...310------....-.-..320....-..-.330..---.....340.......350-.......360.......370......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKKFAY--SE-----PCL-
D
E
E
D
K
K
A
V
L
E
V
L
N
S
K
QL-T-
Q
-
G
K
Y
S
L
L
F
E
E
A
L
C
E
F
LG
V
K
H
A
L
AFN
S
A
T
S
A
-
L
L
T
L
-
Y
R
N
F
SDFNADRN
E
I
I
TT
P
I
-
S
F
V
A
T
A
N
-
M
L
L
ESGY
T
P
V
F
-
A
E
VKN-DG---
N
-
I
D
----
E
L
A
L
E
K
L
I
T
---
K
KT
K
A
I
V
S
V
DYAGKSV
E
I
E
S
I
Q
R
L
C
K
K
Y
S
L
S
FLSDSSHALGSEYQNKKVG
G
F
A
L
A
S
V
F
S
F
HAIK
P
I
TT-AEG
G
A
V
VTN
N
S
E
L
Y
E
K
M
K
L
F
R
SHGM
L
K
K
D
F
FE-----G
E
V
K
SVGYNF
R
L
N
E
I
Q
S
A
L
G
L
S
Q
L
K
KA
P
L
L
R
Q
K
R
E
E
V
A
L
I
Y
D
E
-
I
F-KDNPY--F-T
P
L
H
-
P
L
--
L
KHQSSN-H
L
Y
P
I
L
M
H
---
Q
-
K
F
-------------------
F
T
C
K
K
L
-
I
L
-
E
S
-----
L
H
-KL
G
I
L
V
------
Q
V
H
Y-K-P
I
Y
Q
Y
Q
L
Y
Q
-
Q
L
-FNTAPL---K
S
A
E
D
F
YSAEISLPCHAN-L
D
L
E
S
V
Q
N
I
A
H
G
V
L
K
T
F
E
G
F
NRMGFI
21
PsiBlast_CBE
99.52
91%
-105
- C1 -
2FNU
4
PSEC_HELPY
B:
[1-372]
M
K
E
F
A
Y
--
S
E
-----
P
C
L
-
D
K
E
D
K
K
A
V
L
E
V
L
N
S
K
Q
L
-
T
-
Q
-
G
K
R
S
L
L
F
E
E
A
L
C
E
F
L
G
V
K
H
A
L
V
F
N
S
A
T
S
A
-
L
L
T
L
-
Y
R
N
F
S
E
F
S
A
D
R
N
E
I
I
T
T
P
I
-
S
F
V
A
T
A
N
-
M
L
L
E
S
G
Y
T
P
V
F
-
A
G
I
K
N
-
D
G
---
N
-
I
D
----
E
L
A
L
E
K
L
I
N
---
E
R
T
K
A
I
V
S
V
D
Y
A
G
K
S
V
E
V
E
S
V
Q
K
L
C
K
K
H
S
L
S
F
L
S
D
S
S
H
A
L
G
S
E
Y
Q
N
K
K
V
G
G
F
A
L
A
S
V
F
S
F
H
A
I
K
P
I
T
T
-
A
E
G
G
A
V
V
T
N
D
S
E
L
H
E
K
M
K
L
F
R
S
H
G
M
L
K
K
D
F
F
E
-----
G
E
V
K
S
I
G
H
N
F
R
L
N
E
I
Q
S
A
L
G
L
S
Q
L
K
K
A
P
F
L
M
Q
K
R
E
E
A
A
L
T
Y
D
R
-
I
F
-
K
D
N
P
Y
--
F
-
T
P
L
H
-
P
L
--
L
K
D
K
S
S
N
-
H
L
Y
P
I
L
M
H
---
Q
-
K
F
-------------------
F
T
C
K
K
L
-
I
L
-
E
S
-----
L
H
-
K
R
G
I
L
A
------
Q
V
H
Y
-
K
-
P
I
Y
Q
Y
Q
L
Y
Q
-
Q
L
-
F
N
T
A
P
L
---
K
S
A
E
D
F
Y
H
A
E
I
S
L
P
C
H
A
N
-
L
N
L
E
S
V
Q
N
I
A
H
S
V
L
K
T
F
E
S
F
K
I
----
43
HHSearch
98.21
91%
-102
* C1 *
2FNU
4
PSEC_HELPY
A:
[1-373]
M
K
E
F
A
Y
--
S
E
-----
P
C
L
-
D
K
E
D
K
K
A
V
L
E
V
L
N
S
K
Q
L
-
T
-
Q
-
G
K
R
S
L
L
F
E
E
A
L
C
E
F
L
G
V
K
H
A
L
V
F
N
S
A
T
S
A
-
L
L
T
L
-
Y
R
N
F
S
E
F
S
A
D
R
N
E
I
I
T
T
P
I
-
S
F
V
A
T
A
N
-
M
L
L
E
S
G
Y
T
P
V
F
-
A
G
I
K
N
-
D
G
---
N
-
I
D
----
E
L
A
L
E
K
L
I
N
---
E
R
T
K
A
I
V
S
V
D
Y
A
G
K
S
V
E
V
E
S
V
Q
K
L
C
K
K
H
S
L
S
F
L
S
D
S
S
H
A
L
G
S
E
Y
Q
N
K
K
V
G
G
F
A
L
A
S
V
F
S
F
H
A
I
K
P
I
T
T
-
A
E
G
G
A
V
V
T
N
D
S
E
L
H
E
K
M
K
L
F
R
S
H
G
M
L
K
K
D
F
F
E
-----
G
E
V
K
S
I
G
H
N
F
R
L
N
E
I
Q
S
A
L
G
L
S
Q
L
K
K
A
P
F
L
M
Q
K
R
E
E
A
A
L
T
Y
D
R
-
I
F
-
K
D
N
P
Y
--
F
-
T
P
L
H
-
P
L
--
L
K
D
K
S
S
N
-
H
L
Y
P
I
L
M
H
---
Q
-
K
F
-------------------
F
T
C
K
K
L
-
I
L
-
E
S
-----
L
H
-
K
R
G
I
L
A
------
Q
V
H
Y
-
K
-
P
I
Y
Q
Y
Q
L
Y
Q
-
Q
L
-
F
N
T
A
P
L
---
K
S
A
E
D
F
Y
H
A
E
I
S
L
P
C
H
A
N
-
L
N
L
E
S
V
Q
N
I
A
H
S
V
L
K
T
F
E
S
F
K
-----
3
PsiBlast_PDB
97.97
91%
-103
- C1 -
2FNU
4
PSEC_HELPY
A:
[1-372]
M
K
E
F
A
Y
--
S
E
-----
P
C
L
-
D
K
E
D
K
K
A
V
L
E
V
L
N
S
K
Q
L
-
T
-
Q
-
G
K
R
S
L
L
F
E
E
A
L
C
E
F
L
G
V
K
H
A
L
V
F
N
S
A
T
S
A
-
L
L
T
L
-
Y
R
N
F
S
E
F
S
A
D
R
N
E
I
I
T
T
P
I
-
S
F
V
A
T
A
N
-
M
L
L
E
S
G
Y
T
P
V
F
-
A
G
I
K
N
-
D
G
---
N
-
I
D
----
E
L
A
L
E
K
L
I
N
---
E
R
T
K
A
I
V
S
V
D
Y
A
G
K
S
V
E
V
E
S
V
Q
K
L
C
K
K
H
S
L
S
F
L
S
D
S
S
H
A
L
G
S
E
Y
Q
N
K
K
V
G
G
F
A
L
A
S
V
F
S
F
H
A
I
K
P
I
T
T
-
A
E
G
G
A
V
V
T
N
D
S
E
L
H
E
K
M
K
L
F
R
S
H
G
M
L
K
K
D
F
F
E
-----
G
E
V
K
S
I
G
H
N
F
R
L
N
E
I
Q
S
A
L
G
L
S
Q
L
K
K
A
P
F
L
M
Q
K
R
E
E
A
A
L
T
Y
D
R
-
I
F
-
K
D
N
P
Y
--
F
-
T
P
L
H
-
P
L
--
L
K
D
K
S
S
N
-
H
L
Y
P
I
L
M
H
---
Q
-
K
F
-------------------
F
T
C
K
K
L
-
I
L
-
E
S
-----
L
H
-
K
R
G
I
L
A
------
Q
V
H
Y
-
K
-
P
I
Y
Q
Y
Q
L
Y
Q
-
Q
L
-
F
N
T
A
P
L
---
K
S
A
E
D
F
Y
H
A
E
I
S
L
P
C
H
A
N
-
L
N
L
E
S
V
Q
N
I
A
H
S
V
L
K
T
F
E
S
F
K
-----
23
PsiBlast_CBE
97.69
91%
-104
- C1 -
2FN6
2
PSEC_HELPY
B:
[2-372]
-
K
E
F
A
Y
--
S
E
-----
P
C
L
-
D
K
E
D
K
K
A
V
L
E
V
L
N
S
K
Q
L
-
T
-
Q
-
G
K
R
S
L
L
F
E
E
A
L
C
E
F
L
G
V
K
H
A
L
V
F
N
S
A
T
S
A
-
L
L
T
L
-
Y
R
N
F
S
E
F
S
A
D
R
N
E
I
I
T
T
P
I
-
S
F
V
A
T
A
N
-
M
L
L
E
S
G
Y
T
P
V
F
-
A
G
I
K
N
-
D
G
---
N
-
I
D
----
E
L
A
L
E
K
L
I
N
---
E
R
T
K
A
I
V
S
V
D
Y
A
G
K
S
V
E
V
E
S
V
Q
K
L
C
K
K
H
S
L
S
F
L
S
D
S
S
H
A
L
G
S
E
Y
Q
N
K
K
V
G
G
F
A
L
A
S
V
F
S
F
H
A
I
K
P
I
T
T
-
A
E
G
G
A
V
V
T
N
D
S
E
L
H
E
K
M
K
L
F
R
S
H
G
M
L
K
K
D
F
F
E
-----
G
E
V
K
S
I
G
H
N
F
R
L
N
E
I
Q
S
A
L
G
L
S
Q
L
K
K
A
P
F
L
M
Q
K
R
E
E
A
A
L
T
Y
D
R
-
I
F
-
K
D
N
P
Y
--
F
-
T
P
L
H
-
P
L
--
L
K
D
K
S
S
N
-
H
L
Y
P
I
L
M
H
---
Q
-
K
F
-------------------
F
T
C
K
K
L
-
I
L
-
E
S
-----
L
H
-
K
R
G
I
L
A
------
Q
V
H
Y
-
K
-
P
I
Y
Q
Y
Q
L
Y
Q
-
Q
L
-
F
N
T
A
P
L
---
K
S
A
E
D
F
Y
H
A
E
I
S
L
P
C
H
A
N
-
L
N
L
E
S
V
Q
N
I
A
H
S
V
L
K
T
F
E
S
F
------
22
PsiBlast_CBE
97.42
91%
-105
- C1 -
2FNI
2
PSEC_HELPY
B:
[1-372]
M
K
E
F
A
Y
--
S
E
-----
P
C
L
-
D
K
E
D
K
K
A
V
L
E
V
L
N
S
K
Q
L
-
T
-
Q
-
G
K
R
S
L
L
F
E
E
A
L
C
E
F
L
G
V
K
H
A
L
V
F
N
S
A
T
S
A
-
L
L
T
L
-
Y
R
N
F
S
E
F
S
A
D
R
N
E
I
I
T
T
P
I
-
S
F
V
A
T
A
N
-
M
L
L
E
S
G
Y
T
P
V
F
-
A
G
I
K
N
-
D
G
---
N
-
I
D
----
E
L
A
L
E
K
L
I
N
---
E
R
T
K
A
I
V
S
V
D
Y
A
G
K
S
V
E
V
E
S
V
Q
K
L
C
K
K
H
S
L
S
F
L
S
D
S
S
H
A
L
G
S
E
Y
Q
N
K
K
V
G
G
F
A
L
A
S
V
F
S
F
H
A
I
K
P
I
T
T
-
A
E
G
G
A
V
V
T
N
D
S
E
L
H
E
K
M
K
L
F
R
S
H
G
M
L
K
K
D
F
F
E
-----
G
E
V
K
S
I
G
H
N
F
R
L
N
E
I
Q
S
A
L
G
L
S
Q
L
K
K
A
P
F
L
M
Q
K
R
E
E
A
A
L
T
Y
D
R
-
I
F
-
K
D
N
P
Y
--
F
-
T
P
L
H
-
P
L
--
L
K
D
K
S
S
N
-
H
L
Y
P
I
L
M
H
---
Q
-
K
F
-------------------
F
T
C
K
K
L
-
I
L
-
E
S
-----
L
H
-
K
R
G
I
L
A
------
Q
V
H
Y
-
K
-
P
I
Y
Q
Y
Q
L
Y
Q
-
Q
L
-
F
N
T
A
P
L
---
K
S
A
E
D
F
Y
H
A
E
I
S
L
P
C
H
A
N
-
L
N
L
E
S
V
Q
N
I
A
H
S
V
L
K
T
F
E
S
F
K
I
----
2
PsiBlast_PDB
97.22
91%
-103
- C1 -
2FNI
2
PSEC_HELPY
A:
[1-372]
M
K
E
F
A
Y
--
S
E
-----
P
C
L
-
D
K
E
D
K
K
A
V
L
E
V
L
N
S
K
Q
L
-
T
-
Q
-
G
K
R
S
L
L
F
E
E
A
L
C
E
F
L
G
V
K
H
A
L
V
F
N
S
A
T
S
A
-
L
L
T
L
-
Y
R
N
F
S
E
F
S
A
D
R
N
E
I
I
T
T
P
I
-
S
F
V
A
T
A
N
-
M
L
L
E
S
G
Y
T
P
V
F
-
A
G
I
K
N
-
D
G
---
N
-
I
D
----
E
L
A
L
E
K
L
I
N
---
E
R
T
K
A
I
V
S
V
D
Y
A
G
K
S
V
E
V
E
S
V
Q
K
L
C
K
K
H
S
L
S
F
L
S
D
S
S
H
A
L
G
S
E
Y
Q
N
K
K
V
G
G
F
A
L
A
S
V
F
S
F
H
A
I
K
P
I
T
T
-
A
E
G
G
A
V
V
T
N
D
S
E
L
H
E
K
M
K
L
F
R
S
H
G
M
L
K
K
D
F
F
E
-----
G
E
V
K
S
I
G
H
N
F
R
L
N
E
I
Q
S
A
L
G
L
S
Q
L
K
K
A
P
F
L
M
Q
K
R
E
E
A
A
L
T
Y
D
R
-
I
F
-
K
D
N
P
Y
--
F
-
T
P
L
H
-
P
L
--
L
K
D
K
S
S
N
-
H
L
Y
P
I
L
M
H
---
Q
-
K
F
-------------------
F
T
C
K
K
L
-
I
L
-
E
S
-----
L
H
-
K
R
G
I
L
A
------
Q
V
H
Y
-
K
-
P
I
Y
Q
Y
Q
L
Y
Q
-
Q
L
-
F
N
T
A
P
L
---
K
S
A
E
D
F
Y
H
A
E
I
S
L
P
C
H
A
N
-
L
N
L
E
S
V
Q
N
I
A
H
S
V
L
K
T
F
E
S
F
K
I
----
1
PsiBlast_PDB
96.45
91%
-106
- C1 -
2FN6
2
PSEC_HELPY
A:
[2-372]
-
K
E
F
A
Y
--
S
E
-----
P
C
L
-
D
K
E
D
K
K
A
V
L
E
V
L
N
S
K
Q
L
-
T
-
Q
-
G
K
R
S
L
L
F
E
E
A
L
C
E
F
L
G
V
K
H
A
L
V
F
N
S
A
T
S
A
-
L
L
T
L
-
Y
R
N
F
S
E
F
S
A
D
R
N
E
I
I
T
T
P
I
-
S
F
V
A
T
A
N
-
M
L
L
E
S
G
Y
T
P
V
F
-
A
G
I
K
N
-
D
G
---
N
-
I
D
----
E
L
A
L
E
K
L
I
N
---
E
R
T
K
A
I
V
S
V
D
Y
A
G
K
S
V
E
V
E
S
V
Q
K
L
C
K
K
H
S
L
S
F
L
S
D
S
S
H
A
L
G
S
E
Y
Q
N
K
K
V
G
G
F
A
L
A
S
V
F
S
F
H
A
I
K
P
I
T
T
-
A
E
G
G
A
V
V
T
N
D
S
E
L
H
E
K
M
K
L
F
R
S
H
G
M
L
K
K
D
F
F
E
-----
G
E
V
K
S
I
G
H
N
F
R
L
N
E
I
Q
S
A
L
G
L
S
Q
L
K
K
A
P
F
L
M
Q
K
R
E
E
A
A
L
T
Y
D
R
-
I
F
-
K
D
N
P
Y
--
F
-
T
P
L
H
-
P
L
--
L
K
D
K
S
S
N
-
H
L
Y
P
I
L
M
H
---
Q
-
K
F
-------------------
F
T
C
K
K
L
-
I
L
-
E
S
-----
L
H
-
K
R
G
I
L
A
------
Q
V
H
Y
-
K
-
P
I
Y
Q
Y
Q
L
Y
Q
-
Q
L
-
F
N
T
A
P
L
---
K
S
A
E
D
F
Y
H
A
E
I
S
L
P
C
H
A
N
-
L
N
L
E
S
V
Q
N
I
A
H
S
V
L
K
T
F
E
S
F
K
-----
51
HHSearch
71.10
28%
-86
- C1 -
1MDO
1
ARNB_SALTY
A:
[9-384]
-
D
F
L
P
F
--
S
R
-----
P
A
M
-
G
A
E
E
L
A
A
V
K
T
V
L
D
S
G
W
I
-
T
-
T
-
G
P
K
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
-
M
H
I
A
-
L
M
A
L
G
-
I
-
G
E
G
D
E
V
I
T
P
S
M
-
T
W
V
S
T
L
N
-
M
I
V
L
L
G
A
N
P
V
M
-
V
D
V
D
R
-
D
T
L--
M
-
V
T
----
P
E
H
I
E
A
A
I
T
---
P
Q
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
-
G
T
A
I
F
S
F
H
A
I
K
N
I
T
C
-
A
E
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
L
G
V
D
---
Q
-----
A
E
V
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
H
Q
-
A
M
-
A
D
L
P
F
--
Q
-
P
L
S
L
-
P
S
--
W
E
H
I
H
A
W
-
H
L
F
I
I
R
V
D
---
E
-
A
R
C------------------
G
I
T
R
D
A
-
L
M
-
A
S
-----
L
K
-
T
K
G
I
G
T
------
G
L
H
F
-
R
-
A
A
H
T
Q
K
Y
Y
R
-
E
R
-
F
P
T
L
T
L
---
P
D
T
E
W
N
S
E
R
I
C
S
L
P
L
F
P
D
-
M
T
E
S
D
F
D
R
V
I
T
A
L
H
Q
I
A
G
--------
8
PsiBlast_PDB
65.47
28%
-80
- C1 -
4LC3
10
?
A:
[19-391]
-----
F
--
T
R
-----
P
E
I
-
D
E
E
T
I
Q
G
V
V
E
V
L
R
S
G
W
I
-
T
-
T
-
G
P
Q
C
Q
K
F
E
A
A
L
S
E
Y
C
G
G
R
P
V
R
V
F
N
S
G
T
C
T
-
L
E
I
G
-
L
R
I
A
G
V
G
P
G
D
--
E
V
I
T
T
P
A
-
S
W
V
S
T
S
N
-
V
I
I
E
T
G
A
T
P
V
F
-
A
D
I
D
P
V
T
R
---
N
-
I
D
----
L
D
K
L
E
Q
A
I
T
---
P
R
T
K
A
I
I
P
V
F
L
S
G
L
P
V
D
M
D
R
L
Y
A
I
A
R
A
H
K
L
R
V
I
E
D
A
A
Q
A
F
G
S
T
W
H
G
K
R
I
G
A
I
G
D
L
V
S
F
S
F
H
A
N
K
N
L
T
T
-
I
E
G
G
A
L
V
L
N
N
E
D
E
A
V
L
A
Q
K
Y
R
L
Q
G
I
T
R
T
G
F
D
G
-----
M
D
C
D
V
L
G
G
K
Y
N
L
T
D
V
A
A
R
V
G
L
G
Q
L
P
H
L
E
R
F
T
A
Q
R
R
A
L
A
R
A
Y
F
A
-
A
F
-
D
G
G
A
A
A
K
L
-
G
V
G
L
-
P
V
--
A
E
F
E
N
G
N
W
H
M
F
L
V
T
L
P
---
L
-
E
R
-------------------
L
T
I
T
R
A
E
F
M
-
A
Q
-----
M
K
-
E
R
G
I
G
T
------
G
I
H
Y
-
P
-
A
I
H
L
F
T
L
Y
R
A
R
G
-
F
K
E
G
M
F
---
P
H
A
E
R
Y
G
A
S
T
V
T
L
P
L
F
T
Q
-
M
T
E
G
D
V
R
R
V
V
D
A
V
N
Q
I
C
E
Q
Y
G
K
----
50
HHSearch
65.12
29%
-82
- C1 -
3DR4
2
GDPPS_CAUCR
A:
[28-390]
----
S
V
--
A
A
-----
P
R
L
-
D
G
N
E
R
D
Y
V
L
E
C
M
D
T
T
W
I
S
S
-
V
-
G
R
F
I
V
E
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
-
L
H
L
A
-
L
V
A
M
G
-
I
-
G
P
G
D
E
V
I
V
P
S
L
-
T
Y
I
A
S
A
N
-
S
V
T
Y
C
G
A
T
P
V
L
-
V
D
N
D
P
-
R
T
F--
N
-
L
D
----
A
A
K
L
E
A
L
I
T
---
P
R
T
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
F
G
N
A
I
I
T
T
-
G
E
G
G
M
I
T
T
N
D
D
D
L
A
A
K
M
R
L
L
R
G
Q
G
M
D
P
N
--
R
R
-----
Y
W
F
P
I
V
G
F
N
Y
R
M
T
N
I
Q
A
A
I
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
E
Q
-
K
L
-
A
R
L
-
G
--
N
-
R
V
T
K
-
P
H
V
A
L
T
G
R
H
V
F
-
W
M
Y
T
V
R
L
G
---
E
-
G
L
-------------------
S
T
T
R
D
Q
-
V
I
-
K
D
-----
L
D
-
A
L
G
I
E
S
------
R
P
V
F
-
H
-
P
M
H
I
M
P
P
Y
A
-
H
L
--
A
T
D
D
L
---
K
I
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
-
L
T
E
A
D
I
D
R
V
I
A
A
L
D
Q
V
L
V
--------
6
PsiBlast_PDB
64.61
30%
-80
- C1 -
3DR4
2
GDPPS_CAUCR
A:
[28-382]
----
S
V
--
A
A
-----
P
R
L
-
D
G
N
E
R
D
Y
V
L
E
C
M
D
T
T
W
I
-
S
-
S
V
G
R
F
I
V
E
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
-
L
H
L
A
-
L
V
A
M
G
I
G
P
G
D
--
E
V
I
V
P
S
L
-
T
Y
I
A
S
A
N
-
S
V
T
Y
C
G
A
T
P
V
L
---
V
D
N
-
D
P
RTF
N
-
L
D
----
A
A
K
L
E
A
L
I
T
---
P
R
T
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
F
G
N
A
I
I
T
T
-
G
E
G
G
M
I
T
T
N
D
D
D
L
A
A
K
M
R
L
L
R
G
Q
G
M
D
P
N
R
R
Y
W
-----
F
P
I
--
V
G
F
N
Y
R
M
T
N
I
Q
A
A
I
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
E
Q
K
L
A
-
R
L
G
N
R
--
V
-
T
K
P
H
-
V
A
--
L
T
G
R
H
V
F
-
W
M
Y
T
V
R
L
G
---
E
-
G
L
-------------------
S
T
T
R
D
Q
-
V
I
-
K
D
-----
L
D
-
A
L
G
I
E
S
------
R
P
V
F
-
H
-
P
M
H
I
M
P
P
Y
A
-
H
L
--
A
T
D
D
L
---
K
I
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
-
L
T
E
A
D
I
D
R
V
I
A
A
L
D
Q
V
L
V
--------
45
HHSearch
64.45
26%
-87
- C1 -
3FRK
2
?
A:
[2-365]
--
K
I
S
F
AS
F
K
P
M
H
--
D
E
I
-
E
Y
E
I
K
F
K
F
E
E
I
Y
K
R
N
W
F
-
I
-
L
-
G
D
E
D
K
K
F
E
Q
E
F
A
D
Y
C
N
V
N
Y
C
I
G
C
G
N
G
L
D
A
-
L
H
L
I
-
L
K
G
Y
D
-
I
-
G
F
G
D
E
V
I
V
P
S
N
-
T
F
I
A
T
A
L
-
A
V
S
Y
T
G
A
K
P
I
F
-
V
E
P
D
I
-
R
T
Y--
N
-
I
D
----
P
S
L
I
E
S
A
I
T
---
E
K
T
K
A
I
I
A
V
H
L
Y
G
Q
P
A
D
M
D
E
I
K
R
I
A
K
K
Y
N
L
K
L
I
E
D
A
A
Q
A
H
G
S
L
Y
K
G
M
K
V
G
S
L
G
D
A
A
G
F
S
F
Y
P
A
K
N
L
G
S
L
G
D
G
G
A
V
V
T
N
D
K
D
L
A
E
K
I
K
A
L
S
N
Y
G
S
E
----
K
K
-----
Y
H
H
I
Y
K
G
F
N
S
R
L
D
E
L
Q
A
G
F
L
R
V
K
L
K
Y
L
D
K
W
N
E
E
R
R
K
I
A
Q
K
Y
I
A
-
G
I
-
N
N
P
-
N
--
V
-
I
I
P
V
-
E
A
--
D
Y
A
K
H
V
W
-
Y
T
F
V
I
R
S
E
----------------------------
K
R
D
E
-
L
Q
-
K
Y
-----
L
N
-
N
N
G
I
G
T
------
L
I
H
Y
P
I
-
P
I
H
L
Q
Q
A
Y
K
-
D
L
G
F
K
T
G
N
F
---
P
I
A
E
K
I
A
N
E
I
L
S
I
P
I
W
Y
G
-
M
K
N
E
E
I
E
Y
V
I
D
K
I
N
A
W
K
---------
54
HHSearch
64.16
25%
-84
- C1 -
2OGA
7
DESV_STRVZ
A:
[40-397]
---------------
E
E
L
-
R
A
E
T
D
A
A
I
A
R
V
L
D
S
G
R
Y
-
L
-
L
-
G
P
E
L
E
G
F
E
A
E
F
A
A
Y
C
E
T
D
H
A
V
G
V
N
S
G
M
D
A
-
L
Q
L
A
-
L
R
G
L
G
-
I
-
G
P
G
D
E
V
I
V
P
S
H
-
T
Y
I
A
S
W
L
-
A
V
S
A
T
G
A
T
P
V
P
-
V
E
P
H
E
-
D
H
P--
T
-
L
D
----
P
L
L
V
E
K
A
I
T
---
P
R
T
R
A
L
L
P
V
H
L
Y
G
H
P
A
D
M
D
A
L
R
E
L
A
D
R
H
G
L
H
I
V
E
D
A
A
Q
A
H
G
A
R
Y
R
G
R
R
I
G
A
G
S
S
V
A
A
F
S
F
Y
P
G
K
N
L
G
C
F
G
D
G
G
A
V
V
T
G
D
P
E
L
A
E
R
L
R
M
L
R
N
Y
G
S
R
----
Q
K
-----
Y
S
H
E
T
K
G
T
N
S
R
L
D
E
M
Q
A
A
V
L
R
I
R
L
A
H
L
D
S
W
N
G
R
R
S
A
L
A
A
E
Y
L
S
-
G
L
-
A
G
L
P
G
--
I
-
G
L
P
V
-
T
A
--
P
D
T
D
P
V
W
-
H
L
F
T
V
R
T
E
----------------------------
R
R
D
E
-
L
R
-
S
H
-----
L
D
-
A
R
G
I
D
T
------
L
T
H
Y
P
V
-
P
V
H
L
S
P
A
Y
A
-
G
E
A
P
P
E
G
S
L
---
P
R
A
E
S
F
A
R
Q
V
L
S
L
P
I
G
P
H
-
L
E
R
P
Q
A
L
R
V
I
D
A
V
R
E
W
A
E
R
V
D
-----
20
PsiBlast_PDB
63.98
26%
-81
- C1 -
4ZTC
1
?
A:
[2-385]
--
R
F
F
L
--
S
P
-----
P
H
M
-
G
G
N
E
L
K
Y
I
E
E
V
F
K
S
N
Y
I
-
A
-
P
L
G
E
F
V
N
R
F
E
Q
S
V
K
D
Y
S
K
S
E
N
A
L
A
L
N
S
A
T
A
A
-
L
H
L
A
-
L
R
-
V
A
G
V
K
Q
D
-
D
I
V
L
A
S
S
F
-
T
F
I
A
S
V
A
-
P
I
C
Y
L
K
A
K
P
V
F
-
I
D
C
D
E
-
T
Y
---
N
-
I
D
V
D
L
L
K
L
A
I
-
K
E
C
E
---
K
K
P
K
A
L
I
L
T
H
L
Y
G
N
A
A
K
M
D
E
I
V
E
I
C
K
E
N
D
I
V
L
I
E
D
A
A
E
A
L
G
S
F
Y
K
N
K
A
L
G
T
F
G
E
F
G
V
Y
S
Y
N
G
N
A
I
I
T
T
-
S
G
G
G
M
L
I
G
K
N
K
E
K
I
E
K
A
R
F
Y
S
T
Q
A
--
R
E
N
C
L
H
-----
Y
E
H
L
D
Y
G
Y
N
Y
R
L
S
N
V
L
G
A
I
G
V
A
Q
M
E
V
L
E
Q
R
V
L
K
K
R
E
I
Y
E
W
Y
K
E
-
F
L
-
G
E
--
Y
--
F
-
S
F
L
D
-
E
L
--
E
N
S
R
S
N
R
-
W
L
S
T
A
L
I
N
FDK
N
-
E
L
-------------------
N
S
C
Q
K
D
-
I
N
-
I
S
Q
K
N
I
T
L
H
P
K
I
S
K
L
I
E
D
L
K
N
K
Q
I
E
T
-
R
-
P
L
W
K
T
M
H
A
Q
-
E
V
-
F
K
G
A
K
A
Y
L
N
G
N
S
E
L
F
F
Q
K
G
I
C
L
P
S
G
T
A
-
M
S
K
D
D
V
Y
E
I
S
K
L
I
L
K
S
I
K
--------
55
HHSearch
63.90
25%
-87
- C1 -
3UWC
6
?
A:
[4-371]
-
M
R
V
P
Y
--
S
Y
L
E
R
Q
F
A
D
I
-
E
P
-
Y
L
N
D
L
R
E
F
I
K
T
A
D
F
-
T
-
L
-
G
A
E
L
E
K
F
E
K
R
F
A
A
L
H
N
A
P
H
A
I
G
V
G
T
G
T
D
A
-
L
A
M
S
-
F
K
M
L
N
-
I
-
G
A
G
D
E
V
I
T
C
A
N
-
T
F
I
A
S
V
G
-
A
I
V
Q
A
G
A
T
P
V
L
-
V
D
S
E
N
-
G
Y
---
V
-
I
D
----
P
E
K
I
E
A
A
I
T
---
D
K
T
K
A
I
M
P
V
H
Y
T
G
N
I
A
D
M
P
A
L
A
K
I
A
K
K
H
N
L
H
I
V
E
D
A
C
Q
T
I
L
G
R
I
N
D
K
F
V
G
S
W
G
Q
F
A
C
F
S
L
H
P
L
K
N
L
N
V
W
S
D
A
G
V
I
I
T
H
S
D
E
Y
A
E
K
L
R
L
Y
R
N
H
G
L
I
N
----
R
-----
D
V
C
V
E
Y
G
I
N
C
R
M
D
T
I
Q
A
V
I
A
N
R
L
M
N
Q
L
E
T
I
T
E
K
R
R
G
I
A
H
L
Y
D
Q
-
S
F
-
V
D
L
S
E
--
F
I
D
V
P
V
-
R
R
--
E
G
V
Y
H
V
F
-
H
I
Y
V
L
R
V
K
----------------------------
Y
R
D
Q
-
L
F
-
Q
Y
-----
L
K
-
D
N
G
I
E
V
------
K
I
H
Y
-
P
I
A
M
H
L
Q
P
A
A
K
-
S
L
G
Y
Q
Q
G
D
F
---
P
M
A
E
K
H
G
E
A
V
I
T
L
P
A
H
P
Y
-
L
T
E
E
E
I
N
Y
I
I
K
K
V
R
E
F
Y
L
E
K
H
Y
N
---
7
PsiBlast_PDB
63.67
31%
-81
- C1 -
1MDO
1
ARNB_SALTY
A:
[13-362]
-----
F
--
S
R
-----
P
A
M
-
G
A
E
E
L
A
A
V
K
T
V
L
D
S
G
W
I
-
T
-
T
-
G
P
K
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
-
M
H
I
A
-
L
M
A
L
G
I
G
E
G
D
--
E
V
I
T
P
S
M
-
T
W
V
S
T
L
N
-
M
I
V
L
L
G
A
N
P
V
M
-
V
D
V
D
R
-
D
T
L--
M
-
V
T
----
P
E
H
I
E
A
A
I
T
---
P
Q
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
T
A
-
I
F
S
F
H
A
I
K
N
I
T
C
-
A
E
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
-
L
G
V
D
---Q----
A
E
V
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
H
Q
-
A
M
-
A
D
L
P
---
F
-
Q
P
L
S
L
P
S
--
W
E
H
I
H
A
W
-
H
L
F
I
I
R
V
D
---
E
A
R
C
-------------------
G
I
T
R
D
A
-
L
M
-
A
S
-----
L
K
-
T
K
G
I
G
T
------
G
L
H
F
-
R
-
A
A
H
T
Q
K
Y
Y
R
-
E
R
-
F
P
T
L
T
L
---
P
D
T
E
W
N
S
E
R
I
C
S
L
P
L
F
P
D
-
M
T
E
S
D
F
D
R
V
I
T
A
L
H
Q
I
A
G
--------
5
PsiBlast_PDB
63.55
31%
-81
- C1 -
1MDZ
1
ARNB_SALTY
A:
[13-362]
-----
F
--
S
R
-----
P
A
M
-
G
A
E
E
L
A
A
V
K
T
V
L
D
S
G
W
I
-
T
-
T
-
G
P
K
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
-
M
H
I
A
-
L
M
A
L
G
I
G
E
G
D
--
E
V
I
T
P
S
M
-
T
W
V
S
T
L
N
-
M
I
V
L
L
G
A
N
P
V
M
-
V
D
V
D
R
-
D
T
L--
M
-
V
T
----
P
E
H
I
E
A
A
I
T
---
P
Q
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
T
A
-
I
F
S
F
H
A
I
K
N
I
T
C
-
A
E
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
-
L
G
V
D
---Q----
A
E
V
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
H
Q
-
A
M
-
A
D
L
P
---
F
-
Q
P
L
S
L
P
S
--
W
E
H
I
H
A
W
-
H
L
F
I
I
R
V
D
---
E
A
R
C
-------------------
G
I
T
R
D
A
-
L
M
-
A
S
-----
L
K
-
T
K
G
I
G
T
------
G
L
H
F
-
R
-
A
A
H
T
Q
K
Y
Y
R
-
E
R
-
F
P
T
L
T
L
---
P
D
T
E
W
N
S
E
R
I
C
S
L
P
L
F
P
D
-
M
T
E
S
D
F
D
R
V
I
T
A
L
H
Q
I
A
---------
44
HHSearch
62.98
25%
-86
- C1 -
1O69
3
?
A:
[12-385]
--------------------
G
N
E
L
K
Y
I
E
E
V
F
K
S
N
Y
I
-
A
P
L
-
G
E
F
V
N
R
F
E
Q
S
V
K
D
Y
S
K
S
E
N
A
L
A
L
N
S
A
T
A
A
-
L
H
L
A
-
L
R
V
A
G
-
V
-
K
Q
D
D
I
V
L
A
S
S
F
-
T
F
I
A
S
V
A
-
P
I
C
Y
L
K
A
K
P
V
F
-
I
D
C
D
E
-
T
Y
---
N
-
I
D
----
V
D
L
L
K
L
A
I
K
E
CE
K
K
P
K
A
L
I
L
T
H
L
Y
G
N
A
A
K
M
D
E
I
V
E
I
C
K
E
N
D
I
V
L
I
E
D
A
A
E
A
L
G
S
F
Y
K
N
K
A
L
G
T
F
G
E
F
G
V
Y
S
Y
N
G
N
K
I
I
T
T
-
S
G
G
G
M
L
I
G
K
N
K
E
K
I
E
K
A
R
F
Y
S
T
Q
A
R
E
N
--
C
L
H
-----
Y
E
H
L
D
Y
G
Y
N
Y
R
L
S
N
V
L
G
A
I
G
V
A
Q
M
E
V
L
E
Q
R
V
L
K
K
R
E
I
Y
E
W
Y
K
E
-
F
L
-
G
E
Y
F
S
--
F
-
L
D
E
L
-----
E
N
S
R
S
N
R
-
W
L
S
T
A
L
I
N
---
F
-
D
K
NELNA
C
Q
K
D
I
N
I
S
Q
K
N
I
T
L
H
P
K
I
S
K
-
L
I
-
E
D
-----
L
K
-
N
K
Q
I
E
T
------
R
P
L
W
-
K
-
A
M
H
T
Q
E
V
F
K
-
G
A
-
K
-
A
Y
L
N
---
G
N
S
E
L
F
F
Q
K
G
I
C
L
P
S
G
T
A
-
M
S
K
D
D
V
Y
E
I
S
K
L
I
L
K
S
I
K
--------
49
HHSearch
62.96
25%
-78
- C1 -
3NYT
1
WBPE_PSEAE
A:
[1-359]
--
M
I
E
F
--
I
D
L
K
N
Q
Q
A
R
I
-
K
D
K
I
D
A
G
I
Q
R
V
L
R
H
G
Q
Y
-
I
-
L
-
G
P
E
V
T
E
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
-
L
Q
I
V
-
Q
M
A
L
G
-
V
-
G
P
G
D
E
V
I
T
P
G
F
-
T
Y
V
A
T
A
E
-
T
V
A
L
L
G
A
K
P
V
Y
-
V
D
I
D
P
-
R
T
Y--
N
-
L
D
----
P
Q
L
L
E
A
A
I
T
---
P
R
T
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
A
P
L
G
C
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
I
R
Q
I
A
R
H
G
Q
D
R
----
R
-----
Y
H
H
I
R
V
G
V
N
S
R
L
D
T
L
Q
A
A
I
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
D
L
-
S
L
-
K
Q
V
-
G
--
I
-
G
T
P
F
-
I
E
--
V
N
N
I
S
V
Y
-
A
Q
Y
T
V
R
M
D
----------------------------
N
R
E
S
-
V
Q
-
A
S
-----
L
K
-
A
A
G
V
P
T
------
A
V
H
Y
P
I
-
P
L
N
K
Q
P
A
V
A
-
D
---
E
K
A
K
L
---
P
V
G
D
K
A
A
T
Q
V
M
S
L
P
M
H
P
Y
-
L
D
T
A
S
I
K
I
I
C
A
A
L
T
N
-----------
4
PsiBlast_PDB
62.64
31%
-85
- C1 -
1MDX
4
ARNB_SALTY
A:
[13-362]
-----
F
--
S
R
-----
P
A
M
-
G
A
E
E
L
A
A
V
K
T
V
L
D
S
G
W
I
-
T
-
T
-
G
P
K
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
-
M
H
I
A
-
L
M
A
L
G
I
G
E
G
D
--
E
V
I
T
P
S
M
-
T
W
V
S
T
L
N
-
M
I
V
L
L
G
A
N
P
V
M
-
V
D
V
D
R
-
D
T
L--
M
-
V
T
----
P
E
H
I
E
A
A
I
T
---
P
Q
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
T
A
-
I
F
S
F
H
A
I
K
N
I
T
C
-
A
E
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
-
L
------GRAPQ
A
E
V
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
H
Q
-
A
M
-
A
D
L
P
---
F
-
Q
P
L
S
L
P
S
--
W
E
H
I
H
A
W
-
H
L
F
I
I
R
V
D
---
E
A
R
C
-------------------
G
I
T
R
D
A
-
L
M
-
A
S
-----
L
K
-
T
K
G
I
G
T
------
G
L
H
F
-
R
-
A
A
H
T
Q
K
Y
Y
R
-
E
R
-
F
P
T
L
T
L
---
P
D
T
E
W
N
S
E
R
I
C
S
L
P
L
F
P
D
-
M
T
E
S
D
F
D
R
V
I
T
A
L
H
Q
I
A
G
--------
35
Fugue
60.53
30%
-77
- C1 -
1MDO
1
ARNB_SALTY
A:
[9-384]
-
D
F
L
P
F
--
S
R
-----
P
-
A
M
G
A
E
E
L
A
A
V
K
T
V
L
D
S
G
W
I
-
T
-
T
-
G
P
K
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
A
L
G
I
G
E
-----
G
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
-
L
G
A
N
P
V
-
M
V
D
V
D
R
-
D
T
---
L
M
V
T
----
P
E
H
I
E
A
A
I
T
---
P
Q
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
-
T
A
I
F
S
F
H
A
I
K
N
I
T
C
-
A
E
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
L
G
V
D
Q
A
--------
E
V
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
H
Q
--
A
M
A
D
L
P
F
--
Q
-
P
L
S
L
-
P
S
--
W
E
H
I
H
A
W
-
H
L
F
I
I
R
V
D
---
E
-
A
R
-------------------
C
G
I
T
R
D
-
A
L
M
A
S
-----
L
K
-
T
K
G
I
G
T
------
G
L
H
F
-
R
-
A
A
H
T
Q
K
Y
Y
R
-
E
R
-
F
P
T
L
T
L
---
P
D
T
E
W
N
S
E
R
I
C
S
L
P
L
F
P
D
M
T
--
E
S
D
F
D
R
V
I
T
A
L
H
Q
I
A
G
-------