@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1316: (2015-12-22 )
METLQTHRVLQALIGHFTPFLESGITELIINTEQELWLYKINNTREKRGHVLFDKAFLLRFCEQLASFRGLFFDEEHPTLNCSIPFTRYRVSANHFSITTNNQITLNIRVPRLKPLSLEDFTFKVSNPESLKNLALKGHNILISGETSSGKTSLLNALLDCVNKDERVVSVEDSQELDLKAFSNCVGLLVGKQENTRFNYEDALNMAMRLNPDRLIVGEIDTRNAALFLRLGNTGHKGMLSTIHANSAQNTLEALSLNLSMRYTHSLDKDLMRAYFKSAIDVIVHVNKINNERQIAEVLWTKEL
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------.........10..-.-.....20.-.-..-.....30....---....40........50--.......----..60....-....70-.----..-.-....80...---..---.--..90........100-.-......110--..--....---.120----..------.--------------------------....----130-----...-.-...---.-.140-------------.........150.....-..160.--..--.--.-..170.......180.......---190.-......--200.......210.......-220.....-...230.......240.......250....-------------..-.260.-......--270.......280.......----290.-......300..--------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------ME
T
L
Q
T
H
R
V
L
Q
A
L
-
I
-
G
H
F
T
P
F
-
L
-
E
-SG-
I
T
E
L
I
INTEQ
E
---
L
W
L
Y
KINNT
R
E
KRG
H
---
V
L
F
D
K
A
F
----
L
L
R
F
C
E
Q
L
-
A
S
F
R
G
L
-
F
----FD-E-EHP
T
L
N
CSI---P
F
---
T
--
R
Y
R
V
SA
N
H
F
S
I
TTN
N
-
Q
-
I
T
L
N
I
RVPR--LK--PLSL---E
D
F
T
----
F
K------V--------------------------S
N
P
E
----
S
-------
L
K
N
-
L
-ALK---G-
H
N
---------------
I
L
I
SGETSS
G
K
T
S
L
L
N
A
-
L
L
D
CVN--KD--E--
R
-
V
V
SVEDSQEL
D
L
K
A
F
S
N
C
V
G
L
L---VGKQ-ENTRF
N
--
Y
E
D
A
L
N
M
AMRLNP
D
R
L
I
V
G
E
-I-DTR
N
A
A
-
L
F
L
R
LGNTGHK
G
M
L
S
TIHANS
A
Q
N
T
L
E
A
L
S
-------------
L
N
-
L
S
M
R
Y-THSL
D
K
--
D
L
M
R
A
Y
F
K
S
A
I
D
V
I
V
H
V
NKI----N
N
E
R
-
Q
I
A
E
V
L
WTKEL--------------------------------------------------------------------------------------------------
79
HHSearch
93.25
26%
-118
- C4 -
2GZA
2
VIRBB_BRUSU
A:
[23-348]
-------------------------------------------------------------------------------------------------------------------------
N
F
H
-
L
-
E
P
L
R
P
W
-
L
D
D
-
P
Q
-
I
T
E
V
C
V
N
R
P
G
E
---
V
F
C
E
R
A
-
S
A
W
E
Y
Y
A
V
---
P
N
L
D
Y
E
H
----
L
I
S
L
G
T
A
T
-
A
R
F
V
D
Q
-
D
----
I
S
-
D
-
S
R
P
V
L
S
A
I
L
---
P
M
------
G
E
R
I
Q
I
V
R
P
P
A
C
E
H
G
-
T
-
I
S
V
T
I
R
K
P
S
--
F
T
--
R
R
T
L
---
E
D
Y
A
----
Q
Q
------
G
FFKHVRPMSKSLT
P
F
E
Q
E
L
L
A
L
K
E
A
G
D
Y
M
S
----
F
-------
L
R
R
-
A
-
V
Q
L
---
E
-
R
V
---------------
I
V
V
A
G
E
T
G
S
G
K
T
T
L
M
K
A
-
L
M
Q
E
I
P
--
F
D
--
Q
--
R
-
L
I
T
I
E
D
V
P
E
L
F
L
P
D
H
P
N
H
V
H
L
F
---
Y
P
-------
V
T
--
A
A
T
L
L
R
S
C
L
R
M
K
P
T
R
I
L
L
A
E
-
L
-
R
G
G
E
A
Y
-
D
F
I
N
V
A
A
S
G
H
G
G
S
I
T
S
C
H
A
G
S
C
E
L
T
F
E
R
L
A
-------------
L
M
-
V
L
Q
N
R
Q
G
R
Q
L
P
Y
--
E
I
I
R
R
L
L
Y
L
V
V
D
V
V
V
H
V
H
N
G
VHD-
G
T
G
R
-
H
I
S
E
V
W
Y
D
P
N
T
--------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.26
30%
-121
- C4 -
2PT7
-
?
A:
[36-317]
---------------------------------------------------------------------------------------------------------------------------------
F
G
D
F
-
L
-
K
M
E
N
-
I
T
E
I
C
Y
N
G
N
K
V
---
V
W
V
L
K
-
N
N
G
E
W
Q
P
F
D
---
V
R
D
R
K
A
F
S
L
S
R
L
M
H
F
A
R
C
C
-
A
S
F
K
K
K
-
T
----
I
D
-
N
Y
E
N
P
I
L
S
S
N
L
---
A
----
N
--
G
E
R
V
Q
I
V
L
S
P
V
T
V
N
D
-
E
T
I
S
I
S
I
R
I
P
S
K
T
T
Y
--
P
H
S
F
F
E
E
Q
G
F
Y
----
N
L
------
L
--------------------------
D
N
K
E
Q
A
I
S
A
-------
I
K
D
-
G
-
I
A
I
---
G
-
K
N
---------------
V
I
V
C
G
G
T
G
S
G
K
T
T
Y
I
K
S
-
I
M
E
F
I
P
--
K
E
--
E
--
R
-
I
I
S
I
E
D
T
E
E
I
V
F
K
H
H
K
N
Y
T
Q
L
F
---
F
G
G
N
-----
I
T
--
S
A
D
C
L
K
S
C
L
R
M
R
P
D
R
I
I
L
G
E
-
L
-
R
S
S
E
A
Y
-
D
F
Y
N
V
L
C
S
G
H
K
G
T
L
T
T
L
H
A
G
S
S
E
E
A
F
I
R
L
A
N
------------
M
S
-
S
S
N
S
A
-
A
R
N
I
K
F
--
E
S
L
I
E
G
F
K
D
L
I
D
M
I
V
H
I
N
H
H
----
K
Q
C
D
-
E
F
Y
I
K
--------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.95
30%
-117
- C4 -
1G6O
1
?
A:
[36-317]
---------------------------------------------------------------------------------------------------------------------------------
F
G
D
F
-
L
-
K
M
E
N
-
I
T
E
I
C
Y
N
G
N
K
V
---
V
W
V
L
K
-
N
N
G
E
W
Q
P
F
D
---
V
R
D
R
K
A
F
S
L
S
R
L
M
H
F
A
R
C
C
-
A
S
F
K
K
K
-
T
----
I
D
-
N
Y
E
N
P
I
L
S
S
N
L
---
A
----
N
--
G
E
R
V
Q
I
V
L
S
P
V
T
V
N
D
-
E
T
I
S
I
S
I
R
I
P
S
K
T
T
Y
--
P
H
S
F
F
E
E
Q
G
F
Y
----
N
L
------
L
--------------------------
D
N
K
E
Q
A
I
S
A
-------
I
K
D
-
G
-
I
A
I
---
G
-
K
N
---------------
V
I
V
C
G
G
T
G
S
G
K
T
T
Y
I
K
S
-
I
M
E
F
I
P
--
K
E
--
E
--
R
-
I
I
S
I
E
D
T
E
E
I
V
F
K
H
H
K
N
Y
T
Q
L
F
---
F
G
G
N
-----
I
T
--
S
A
D
C
L
K
S
C
L
R
M
R
P
D
R
I
I
L
G
E
-
L
-
R
S
S
E
A
Y
-
D
F
Y
N
V
L
C
S
G
H
K
G
T
L
T
T
L
H
A
G
S
S
E
E
A
F
I
R
L
A
-------------
N
M
-
S
S
S
N
S
-
A
A
R
N
I
K
F
-
E
S
L
I
E
G
F
K
D
L
I
D
M
I
V
H
I
N
H
H
----
K
Q
C
D
-
E
F
Y
I
K
--------------------------------------------------------------------------------------------------------
81
HHSearch
89.49
29%
-121
- C4 -
2PT7
-
?
A:
[28-319]
------------------------------------------------------------------------------------------------------------------------
L
R
H
A
-
T
E
E
L
F
G
D
F
-
L
K
M
-
E
N
-
I
T
E
I
C
Y
N
G
N
K
V
---
V
W
V
L
K
N
N
G
E
W
Q
P
F
D
V
RDR
K
A
F
S
L
S
R
----
L
M
H
F
A
R
C
C
-
A
S
F
K
K
K
-
T
----
I
D
N
Y
-
E
N
P
I
L
S
S
N
L
---
A
N
------
G
E
R
V
Q
I
V
L
S
P
V
T
V
N
D
E
T
-
I
S
I
S
I
R
I
P
S
--
K
T
--
T
Y
P
H
S
F
F
E
E
Q
G
----
F
Y
NLLDN
K
E
--------------------------
Q
A
I
S
----
A
-------
I
K
D
-
G
-
I
A
I
---
G
-
K
N
---------------
V
I
V
C
G
G
T
G
S
G
K
T
T
Y
I
K
S
-
I
M
E
F
I
P
--
K
E
--
E
--
R
-
I
I
S
I
E
D
T
E
E
I
V
F
K
H
H
K
N
Y
T
Q
L
F
---
F
-----
G
G
N
I
T
--
S
A
D
C
L
K
S
C
L
R
M
R
P
D
R
I
I
L
G
E
-
L
-
R
S
S
E
A
Y
-
D
F
Y
N
V
L
C
S
G
H
K
G
T
L
T
T
L
H
A
G
S
S
E
E
A
F
I
R
L
A
-------------
N
M
-
S
S
S
N
S
A
A
R
N
I
K
F
--
E
S
L
I
E
G
F
K
D
L
I
D
M
I
V
H
I
N
H
H
----
K
Q
C
D
-
E
F
Y
I
K
--------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.80
30%
-111
- C4 -
1OPX
1
?
A:
[36-317]
---------------------------------------------------------------------------------------------------------------------------------
F
G
D
F
-
L
-
K
M
E
N
-
I
T
E
I
C
Y
N
G
N
K
V
---
V
W
V
L
K
-
N
N
G
E
W
Q
P
F
D
---
V
R
D
R
K
A
F
S
L
S
R
L
M
H
F
A
R
C
C
-
A
S
F
K
K
K
-
T
----
I
D
-
N
Y
E
N
P
I
L
S
S
N
L
---
A
----
N
--
G
E
R
V
Q
I
V
L
S
P
V
T
V
N
D
-
E
T
I
S
I
S
I
R
I
P
S
K
T
T
Y
--
P
H
S
F
F
E
E
Q
G
F
Y
----
N
L
------
L
--------------------------
D
N
K
E
Q
A
I
S
A
-------
I
K
D
-
G
-
I
A
I
---
G
-
K
N
---------------
V
I
V
C
G
G
T
G
S
G
K
T
T
Y
I
K
S
-
I
M
E
F
I
P
--
K
E
--
E
--
R
-
I
I
S
I
E
D
T
E
E
I
V
F
K
H
H
K
N
Y
T
Q
L
F
---
F
G
G
N
-----
I
T
--
S
A
D
C
L
K
S
C
L
R
M
R
P
D
R
I
I
L
G
E
-
L
-
R
S
S
E
A
Y
-
D
F
Y
N
V
L
C
S
G
H
K
G
T
L
T
T
L
H
A
G
S
S
E
E
A
F
I
R
L
A
-------------
N
M
-
S
S
S
N
S
-
A
A
R
N
I
K
F
-
E
S
L
I
E
G
F
K
D
L
I
D
M
I
V
H
I
N
H
H
----
K
Q
C
D
-
E
F
Y
I
K
--------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
87.95
30%
-112
- C4 -
1NLY
2
?
A:
[36-317]
---------------------------------------------------------------------------------------------------------------------------------
F
G
D
F
-
L
-
K
M
E
N
-
I
T
E
I
C
Y
N
G
N
K
V
---
V
W
V
L
K
-
N
N
G
E
W
Q
P
F
D
---
V
R
D
R
K
A
F
S
L
S
R
L
M
H
F
A
R
C
C
-
A
S
F
K
K
K
-
T
----
I
D
-
N
Y
E
N
P
I
L
S
S
N
L
---
A
----
N
--
G
E
R
V
Q
I
V
L
S
P
V
T
V
N
D
-
E
T
I
S
I
S
I
R
I
P
S
K
T
T
Y
--
P
H
S
F
F
E
E
Q
G
F
Y
----
N
L
------
L
--------------------------
D
N
K
E
Q
A
I
S
A
-------
I
K
D
-
G
-
I
A
I
---
G
-
K
N
---------------
V
I
V
C
G
G
T
G
S
G
K
T
T
Y
I
K
S
-
I
M
E
F
I
P
--
K
E
--
E
--
R
-
I
I
S
I
E
D
T
E
E
I
V
F
K
H
H
K
N
Y
T
Q
L
F
---
F
G
G
N
-----
I
T
--
S
A
D
C
L
K
S
C
L
R
M
R
P
D
R
I
I
L
G
E
-
L
-
R
S
S
E
A
Y
-
D
F
Y
N
V
L
C
S
G
H
K
G
T
L
T
T
L
H
A
G
S
S
E
E
A
F
I
R
L
A
-------------
N
M
-
S
S
S
N
S
-
A
A
R
N
I
K
F
-
E
S
L
I
E
G
F
K
D
L
I
D
M
I
V
H
I
N
H
H
----
K
Q
C
D
-
E
F
Y
I
K
--------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.58
26%
-108
- C4 -
2GZA
2
VIRBB_BRUSU
A:
[31-315]
-----------------------------------------------------------------------------------------------------------------------------------
P
W
-
L
-
D
-
D
P
Q
I
T
E
V
C
V
N
R
P
G
E
---
V
F
C
E
R
-
A
S
A
W
E
Y
Y
A
V
---
P
N
L
D
Y
E
H
----
L
I
S
L
G
T
A
T
-
A
R
F
V
D
Q
-
D
----
I
S
-
D
-
S
R
P
V
L
S
A
I
L
---
P
M
---
G
--
E
-
R
I
Q
I
V
R
P
P
A
C
E
H
G
-
T
-
I
S
V
T
I
R
K
P
S
--
F
T
--
R
R
T
L
---
E
D
Y
A
Q
Q
GF
F
K
------
H
--------------------------
V
R
P
M
----
S
KSLT
P
F
E
Q
E
L
-
L
-
A
L
K
---
E
-
A
G
D
Y
M
S
F
L
R
R
A
V
Q
L
ERV
I
V
V
A
G
E
T
G
S
G
K
T
T
L
M
K
A
-
L
M
Q
E
I
P
--
F
D
--
Q
--
R
-
L
I
T
I
E
D
V
P
E
L
F
L
P
D
H
P
N
H
V
H
L
F
Y
P----------
V
T
--
A
A
T
L
L
R
S
C
L
R
M
K
P
T
R
I
L
L
A
E
-
L
-
R
G
G
E
A
Y
-
D
F
I
N
V
A
A
S
G
H
G
G
S
I
T
S
C
H
A
G
S
C
E
L
T
F
E
R
L
A
-------------
L
M
V
L
Q
N
R
Q
-
G
R
Q
L
P
Y
--
E
I
I
R
R
L
L
Y
L
V
V
D
V
V
V
H
V
H
N
G
----
V
H
D
G
-
T
G
R
H
I
S
E
V
W
Y
D
--------------------------------------------------------------------------------------------------
71
Fugue
72.84
19%
-96
- C4 -
4IHQ
5
?
A:
[2-513]
S
F
V
E
D
Y
L
T
K
LQ
E
R
P
T
I
I
ENPNILKGSKI
F
N
A
I
Y
R
V
D
DF
V
Y
I
H
I
Q
SIKSEDG
Y
N
Q
Y
N
V
I
E
P
P
RPT
H
D
E
M
E
E
I
E
E
K
F
A
L
S
IGD
K
E
P
P
ED
T
K
E
K
E
K
L
I
R
S
I
L
D
K
I
L
L
RMRLSVP
K
E
Y
V
I
Y
H
F
I
R
D
K
L
Y
T
-
G
S
L
E
P
L
-
I
-
R
D
P
Y
-
I
E
D
I
S
I
P
G
L
G
H
---
V
Y
I
V
H
K
V
F
G
P
M
R
T
S
I
---
K
F
E
N
Y
E
E
----
L
D
N
L
I
V
S
L
-
S
E
K
S
Y
R
-
P
----
V
S
-
H
-
N
R
P
V
V
D
A
S
L
---
P
----
D
--
G
S
R
V
N
F
V
Y
G
V
D
I
S
R
R
-
G
-
S
N
L
T
V
R
K
F
S
--
R
V
--
P
T
S
I
---
T
Q
L
I
M
---
F
G
------
T
--------------------------
L
S
S
M
----
M
-------
A
A
Y
-
I
-
W
T
M
L
D
E
G
-
M
N
---------------
L
F
V
C
G
E
T
A
S
G
K
T
T
T
L
N
A
-
I
T
A
F
I
P
--
P
N
--
L
--
K
-
I
V
T
I
E
D
T
P
E
L
T
V
P
H
S
N
W
V
A
E
V
T
---
R
E
T
G
-
G
E
G
T
I
K
--
L
F
D
L
L
K
A
A
L
R
Q
R
P
N
Y
I
L
V
G
A
-
I
-
R
D
K
E
G
N
-
V
A
F
Q
A
M
Q
T
G
H
-
S
V
M
A
T
F
H
A
A
N
I
T
T
L
I
Q
R
L
T
-------------------
G
Y
-
P
I
E
V
P
K
--
S
Y
I
N
N
L
N
I
A
L
F
Q
T
A
L
Y
D
K
K
G
----
N
L
I
R
-
R
V
V
E
V
D
E
I
I
D
I
DPVTN
D
V
V
Y
I
PA
F
T
Y
D
SVQD
K
M
L
F
AGKGSSYLIENK
I
A
V
K
R
GIDRRNI
G
L
L
Y
D
E
L
Q
M
R
S
R
F
L
N
L
L
V
E
K
KIFN
Y
Y
D
V
W
D
Y
I
L
R
A
R
Q
MG
L
E
E
A
I
K
Y
V
SNI
83
HHSearch
70.17
20%
-85
- C4 -
3JVV
3
PILT_PSEAE
A:
[11-284]
--------------------------------------------------------------------------------------------------------------------------------------
A
-
K
-
Q
G
-
A
S
D
L
H
L
S
A
G
L
P
---
P
M
-
I
R
V
D
G
D
V
R
R
I
N
L
---
P
P
L
E
H
K
Q
----
V
H
A
L
I
Y
D
I
-
M
N
D
K
Q
R
K
D
----
F
E
-
E
F
L
E
T
D
F
S
F
E
V
---
P
G
V
--
A
--
R
F
R
V
N
A
F
--
N
Q
N
--
R
-
G
-
A
G
A
V
F
R
T
I
P
--
S
K
--
V
L
T
M
---
E
E
L
G
----
M
G
------
E
----------------------------------
V
-------
F
K
R
V
S
-
D
V
P
---
R
-
G
L
---------------
V
L
V
T
G
P
T
G
S
G
K
S
T
T
L
A
A
-
M
L
D
Y
L
N
--
N
T
KY
H
--
H
-
I
L
T
I
E
D
P
I
E
F
V
H
E
S
---
K
K
C
L
V
---
N
Q
R
E
V
H
R
D
T
L
G
--
F
S
E
A
L
R
S
A
L
R
E
D
P
D
I
I
L
V
G
E
-
M
-
R
D
L
E
T
I
R
L
A
L
T
A
A
E
T
G
H
L
-
V
F
G
T
L
H
T
T
S
A
A
K
T
I
D
R
V
V
-------------
D
V
-
F
P
A
E
------
E
K
--
A
M
V
R
S
M
L
S
E
S
L
Q
S
V
I
S
Q
T
L
I
K
K-----
R
V
A
A
H
E
I
M
I
G
T
P
A
--------------------------------------------------------------------------------------------------
84
HHSearch
66.71
20%
-99
- C4 -
1P9R
1
GSPE_VIBCH
A:
[41-284]
---------------------------------------------------------------------------------------------------------------------------------
L
G
E
A
-
I
-
K
-
E
G
-
A
S
D
I
H
I
E
T
F
E
K
T
L
S
I
R
-
F
R
V
D
G
V
L
R
E
V
L
A
-----
P
S
R
K
L
----
S
S
L
L
V
S
R
V
-
K
V
M
A
K
L
-
D
IAEK
R
V
-
P
-
Q
D
G
R
I
S
L
-----------AV
D
V
R
V
S
T
M
--
P
S
S
--
H
-
G
-
E
R
V
V
M
R
L
L
D
--
K
N
AT
R
L
D
L
---
H
S
L
G
----
M
T
------
A
--------------------------
H
N
H
D
----
N
-------
F
R
R
-
L
I
K
R
P
---
H
-
G
I
---------------
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
-
G
L
Q
E
L
N
--
S
S
E-
R
--
N
-
I
L
T
V
E
D
P
I
E
F
D
I
D
G
I
-
G
Q
T
Q
V
N
--------
P
R
V
D
M
T
--
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
V
V
M
V
G
E
-
I
-
R
D
L
E
T
A
Q
I
A
V
Q
A
S
L
T
G
H
L
-
V
M
S
T
L
H
T
N
T
A
V
G
A
V
T
R
L
R
-------------
D
M
-
G
I
E
P
F
-
L
I
S
S
S
L
--
L
G
V
L
A
Q
R
L
V
R
T
L
C
P
D
C
K
E
P
Y
----
E
A
D
K
-
E
Q
R
K
L
F
E
P
L
I
L
--------------------------------------------------------------------------------------------------
72
Fugue
65.59
16%
-92
- C4 -
2GSZ
-
?
A:
[1-349]
-----------------------------------------------------------------------------------------------------------------
E
L
K
I
L
E
I
I
K
E
A
-
I
-
E
L
----------
G
-
A
S
D
I
H
L
T
A
G
A
P
---
P
A
V
R
I
D
G
Y
I
K
F
L
K
D
F
---
P
R
L
T
P
E
D
----
T
Q
K
L
A
Y
S
V
M
S
E
K
H
R
Q
-
K
----
L
E
-
E
-
N
G
Q
-
V
D
F
S
F
G
VR
G
V
---
G
--
R
F
R
A
N
V
----
F
Y
Q
R
G
-
S
-
V
A
A
A
L
R
S
L
P
--
A
E
--
I
P
E
F
---
K
K
L
G
----
L
------------------------------------
P
D
----
K
-------
V
L
E
-
L
-
C
H
R
---
K
M
G
L
---------------
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
M
I
D
Y
I
N
Q
--
T
K
--
S
Y
-
H
-
I
I
T
I
E
D
P
I
E
Y
V
F
K
H
K
K
S
I
V
N
Q
R
---
E
V
G
E
-
D
T
K
--
S
--
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
M
R
-
D
L
E
T
V
E
-
T
A
L
R
A
A
E
T
G
H
-
L
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
-------------------
V
D
I
-
F
P
L
N
Q
Q
--
E
Q
V
R
I
V
L
S
F
I
L
Q
G
I
I
S
Q
R
L
L
P
K
IG
G
G
R
V
-
L
A
Y
E
L
L
I
P
N
T
A
I
R
N
L
I
R
E
NKL
Q
Q
V
Y
S
L
MQMQT
M
N
Q
T
L
Y
K
L
Y
K
Q
GLIT
L
E
D
A
M
E
ASPDPKELER----------------------------------------------
82
HHSearch
64.72
18%
-87
- C4 -
2EWV
1
?
A:
[12-298]
-------------------------------------------------------------------------------------------------------------------------
E
L
K
-
I
-
L
E
I
I
K
E
A
I
-
E
-
L
G
-
A
S
D
I
H
L
T
A
G
A
P
---
P
A
V
-
R
I
D
G
Y
I
K
F
L
K
D
F--
P
R
L
T
P
E
D
----
T
Q
K
L
A
Y
S
V
-
M
S
E
K
H
R
-
Q
----
K
L
-
E
-
E
N
G
Q
V
D
F
S
F
---
G
V
RG
V
G
--
R
F
R
A
N
V
F
Y
Q
R
----
G
-
S
-
V
A
A
A
L
R
S
L
P
--
A
E
--
I
P
E
F
---
K
K
L
G
----
L
P
------
D
--------------------------
K
-------
V
-------
L
E
L
-
C
-
H
R
K
---
M
-
G
L
---------------
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
-
M
I
D
Y
I
N
--
Q
T
KS
Y
--
H
-
I
I
T
I
E
D
P
I
E
Y
V
F
K
H
K
K
---
S
I
V
---
N
Q
R
E
V
G
E
D
T
K
S
--
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
-
M
-
R
D
L
E
T
V
E
T
A
L
R
A
A
E
T
G
H
L
-
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
-------------
D
I
-
F
P
L
N
------
Q
Q
--
E
Q
V
R
I
V
L
S
F
I
L
Q
G
I
I
S
Q
R
L
L
P
K
IG
G
G
R
V
-
L
A
Y
E
L
L
I
P
N
T
A
--------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
64.57
31%
-95
- C4 -
2EYU
-
?
A:
[6-139]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
--
F
K
--
K
L
G
L
---
P
D
K
V
----
L
E
------
L
--------------------------
C
H
---------------
R
K
-
M
-
G
L
-----------------------
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
-
M
I
D
Y
I
N
Q
T
K
S
--
Y
--
H
-
I
I
T
I
E
D
P
I
E
Y
V
F
K
H
K
K
S
I
V
N
Q
R
E
--
V
G
---
E
D
T
K
-
S
--
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
-
M
R
D
L
E
T
V
E
-
T
A
L
R
A
A
E
T
G
H
L
-
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
-------------
D
I
-
F
P
L
N
Q
-
Q
E
Q
V
R
I
--
V
L
S
F
I
L
Q
G
I
I
S
Q
R
L
L
P
K
I
G
G
----
G
R
V
L
-
A
Y
G
L
L
I
P
N
T
A
I
--------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.54
26%
-94
- C4 -
4IHQ
5
?
A:
[254-421]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
G
-
M
N
---------------
L
F
V
C
G
E
T
A
S
G
K
T
T
T
L
N
A
-
I
T
A
F
I
P
--
P
N
--
L
--
K
-
I
V
T
I
E
D
T
P
E
L
T
V
-
P
H
S
N
W
V
A
E
V
T
R
E
T
G
G
E
-
G
T
I
K
L
F
----
D
L
L
K
A
A
L
R
Q
R
P
N
Y
I
L
V
G
A
-
I
-
R
D
K
E
G
N
-
V
A
F
Q
A
M
Q
T
G
H
-
S
V
M
A
T
F
H
A
A
N
I
T
T
L
I
Q
R
L
T
G
YPIEVPKSYINN
L
N
-
I
A
L
F
Q
-
T
A
L
Y
D
K
KG
N
L
I
R
R
V
V
E
--
V
D
E
I
I
D
I
D
P
V
----
T
N
D
V
-
V
Y
I
P
A
F
T
Y
D
S
V
--------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.52
27%
-88
- C4 -
4II7
-
?
A:
[254-421]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
G
-
M
N
---------------
L
F
V
C
G
E
T
A
S
G
K
T
T
T
L
N
A
-
I
T
A
F
I
P
--
P
N
--
L
--
K
-
I
V
T
I
E
D
T
P
E
L
T
V
-
P
H
S
N
W
V
A
E
V
T
R
E
T
G
G
E
-
G
T
I
K
L
F
----
D
L
L
K
A
A
L
R
Q
R
P
N
Y
I
L
V
G
E
-
I
-
R
D
K
E
G
N
-
V
A
F
Q
A
M
Q
T
G
H
-
S
V
M
A
T
F
H
A
A
N
I
T
T
L
I
Q
R
L
T
GYPIEVPKSYINN
L
N
-
I
A
L
F
Q
-
T
A
L
Y
D
K
KG
N
L
I
R
R
V
V
E
--
V
D
E
I
I
D
I
D
P
V
----
T
N
D
V
-
V
Y
I
P
A
F
T
Y
D
S
V
--------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
63.37
30%
-95
- C4 -
2EWV
1
?
A:
[111-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
P
A
E
I
P
E
--
F
K
--
K
L
G
L
---
P
D
K
V
----
L
E
------
L
--------------------------
C
H
---------------
R
K
-
M
-
G
L
-----------------------
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
-
M
I
D
Y
I
N
Q
T
K
S
--
Y
--
H
-
I
I
T
I
E
D
P
I
E
Y
V
F
K
H
K
K
S
I
V
N
Q
R
E
--
V
G
---
E
D
T
K
-
S
--
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
-
M
R
D
L
E
T
V
E
-
T
A
L
R
A
A
E
T
G
H
L
-
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
-------------
D
I
-
F
P
L
N
Q
-
Q
E
Q
V
R
I
--
V
L
S
F
I
L
Q
G
I
I
S
Q
R
L
L
P
K
I
G
G
----
G
R
V
L
-
A
Y
E
L
L
I
P
N
T
A
I
--------------------------------------------------------------------------------------------------
85
HHSearch
60.96
23%
-90
- C4 -
2EYU
-
?
A:
[6-171]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
F
---
K
K
L
G
----
L
P
------
D
--------------------------
K
-------
V
-------
L
E
L
-
C
-
H
R
K
---
M
-
G
L
---------------
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
-
M
I
D
Y
I
N
--
Q
T
--
K
S
Y
H
-
I
I
T
I
E
D
P
I
E
Y
V
F
K
H
K
---
K
S
I
V
---
N
Q
R
E
V
G
E
D
T
K
S
--
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
-
M
-
R
D
L
E
T
V
E
T
A
L
R
A
A
E
T
G
H
L
-
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
-------------
D
I
-
F
P
L
N
------
Q
Q
--
E
Q
V
R
I
V
L
S
F
I
L
Q
G
I
I
S
Q
R
L
L
----
P
K
I
G
-
G
G
R
V
L
A
Y
G
L
L
I
--------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
60.67
29%
-94
- C4 -
4PHT
2
?
A:
[238-367]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
--
P
V
N
H
---
D
N
F
R
----
H
L
------
I
--------------------------
S
R
P
H
----
G
-------
I
------------------------------
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
-
G
L
Q
E
L
N
--
S
N
--
E
--
R
N
I
L
T
V
E
D
P
I
E
F
D
I
D
G
I
G
Q
T
----------
Q
-
V
N
P
K
V
D
MT
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
V
V
M
V
G
E
-
I
R
D
L
E
T
A
Q
-
I
A
V
Q
A
S
L
T
G
H
L
-
V
M
S
T
L
H
T
N
T
A
V
G
A
I
T
R
L
R
-------------
D
M
-
G
I
E
P
F
-
L
I
S
S
S
L
--
L
G
V
L
A
Q
R
L
V
R
T
L
C
Q
D
C
K
E
P
Y
----
E
A
D
K
-
E
Q
R
K
L
F
A
L
T
L
Y
--------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
59.79
30%
-83
- C4 -
2EWW
1
?
A:
[111-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
P
A
E
I
P
E
--
F
K
--
K
L
G
L
---
P
D
K
V
----
L
E
------
L
--------------------------
C
H
---------------------
R
K
---
M
-
G
L
---------------
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
-
M
I
D
Y
I
N
Q
T
K
S
--
Y
--
H
-
I
I
T
I
E
D
P
I
E
Y
V
F
K
H
K
K
S
I
V
N
Q
R
E
--
V
G
---
E
D
T
K
-
S
--
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
-
M
R
D
L
E
T
V
E
-
T
A
L
R
A
A
E
T
G
H
L
-
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
-------------
D
I
-
F
P
L
N
Q
-
Q
E
Q
V
R
I
--
V
L
S
F
I
L
Q
G
I
I
S
Q
R
L
L
P
K
I
G
G
----
G
R
V
L
-
A
Y
E
L
L
I
P
N
T
A
I
--------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
58.72
30%
-87
- C4 -
2GSZ
-
?
A:
[100-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
P
A
E
I
P
E
--
F
K
--
K
L
G
L
---
P
D
K
V
----
L
E
------
L
--------------------------
C
H
---------------------
R
K
---
M
-
G
L
---------------
I
L
V
T
G
P
T
G
S
G
K
S
T
T
I
A
S
-
M
I
D
Y
I
N
Q
T
K
S
--
Y
--
H
-
I
I
T
I
E
D
P
I
E
Y
V
F
K
H
K
K
S
I
V
N
Q
R
E
--
V
G
---
E
D
T
K
-
S
--
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
-
M
R
D
L
E
T
V
E
-
T
A
L
R
A
A
E
T
G
H
L
-
V
F
G
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
-------------
D
I
-
F
P
L
N
Q
-
Q
E
Q
V
R
I
--
V
L
S
F
I
L
Q
G
I
I
S
Q
R
L
L
P
K
I
G
G
----
G
R
V
L
-
A
Y
E
L
L
I
P
N
T
A
I
--------------------------------------------------------------------------------------------------