@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0810: (2016-03-18 )
MKQLLKIFVPVIVVALLMMLLATTMNRSEGYAGSNTLTIYNWGDYIDPSLITKFEKETGIKVIYQTFDSNEAMMTKIEQGGTTFDIAVPSDYAISKMKEENLLIPLDHSKLPNEKYLDPRFMDLSFDDDNKYSMPYFWGTLGIIYNKEMFPDKNFDTWNALFDPELKNQILLIDGAREVMGLGLNSLGYSLNDTNKAHLQAARDKLETMTPNVKAIVGDEIKLLMADNEAGVAVTFSGEAAEMLSENEDLEYVIPKDGSNLWFDNMVIPKTAKNVDGAHKFINFMLKPENAAINAEYVGYATPNAKAVELLPKEISSDERFYPDMDELNNLEVYDNLGKRMLSYYNELFLEFKMYRK
Atome Classification :
(20 SA)
.........10........20........30........40..---......50........60........70........-80.........90........100.......110.......---120..---.---.....130.......140....----..-----.150.-----.---.....160..----.-----...-.-170----...----.....180.......190....-...-200........210.......220..-.....----230......---.240----.....------...---.------250.....-.-.260.......270.......280.......290.......300.......310.......320....---...330.......340.......350.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
Q
L
L
K
I
F
V
P
V
I
V
V
A
L
L
M
M
L
L
A
T
TMNRSEGYAGS
N
T
L
T
I
YNWG---DYI
D
P
S
L
I
T
K
F
EKETG
I
K
V
I
Y
Q
TFDSN
E
A
M
M
T
K
I
EQ-G-G
T
T
F
D
I
AVPSD
Y
A
I
S
KMKEE
N
L
L
I
PLDHSKLPNEKYLDP---
R
F
-
M
D---L---SFDDDNKYSM
P
Y
F
W
G
T
L
G
I
I
YN----KE-----MFPDK-----N---FD
T
W
N
ALFDP----E-----LKN-
Q
-
I
L
-----
L
ID----G
A
R
E
V
M
G
L
G
L
N
S
LGYSLNDT
N
K
-
A
H
L
-
Q
A
-
A
R
D
K
L
E
TMTPN
V
K
A
I
VGD
E
I
K
L
L
-
M
ADNE----A
G
V
A
V
T
FSG---
E
A
------
A
E
M
LS------ENE---D------
L
E
Y
VIPKD-G-SN
L
W
FDNMVIPKTAKNV
D
G
A
H
K
F
I
N
F
M
LKPEN
A
A
IN
A
E
Y
V
G
YATPN
A
K
A
V
E
L
L
P
K
EISSDERFYP
D
M
D
---ELNN
L
E
V
Y
D
N
L
G
K
R
M
L
S
Y
Y
N
E
L
F
L
E
F
K
MYRK
1
PsiBlast_PDB
95.89
95%
-94
- C1 -
4GL0
10
?
A:
[10-332]
---------------------------------
S
N
T
L
T
I
Y
N
W
G
---
D
Y
I
D
P
S
L
I
T
K
F
E
K
E
T
G
I
K
V
I
Y
Q
T
F
D
S
N
E
A
M
M
T
K
I
E
Q
-
G
-
G
T
T
F
D
I
A
V
P
S
D
Y
A
I
S
K
M
K
E
E
N
L
L
I
P
L
D
H
S
K
L
P
N
E
K
Y
L
D
P
---
R
F
-
M
D
---
L
---
S
F
D
D
D
N
K
Y
S
M
P
Y
F
W
G
T
L
G
I
I
Y
N
----
K
E
-----
M
F
P
D
K
-----
N
---
F
D
T
W
N
A
L
F
D
P
----
E
-----
L
K
N
-
Q
-
I
L
-----
L
I
D
----
G
A
R
E
V
M
G
L
G
L
N
S
L
G
Y
S
L
N
D
T
N
K
-
A
H
L
-
Q
A
-
A
R
D
K
L
E
T
M
T
P
N
V
K
A
I
V
G
D
E
I
K
L
L
-
M
A
D
N
-----
A
G
V
A
V
T
F
S
G
---
E
A
------
A
E
M
L
S
------
E
N
E
---
D
------
L
E
Y
V
I
P
K
D
-
G
-
S
N
L
W
F
D
N
M
V
I
P
K
T
A
K
N
V
D
G
A
H
K
F
I
N
F
M
L
K
P
E
N
A
A
I
N
A
E
Y
V
G
Y
A
T
P
N
A
K
A
V
E
L
L
P
K
E
I
S
S
D
E
R
F
Y
P
D
M
D
---
E
L
N
N
L
E
V
Y
D
N
L
G
K
R
M
L
S
Y
Y
N
E
L
F
L
E
F
K
M
Y
R
-
2
PsiBlast_PDB
87.90
60%
-97
- C1 -
4EQB
7
?
A:
[8-330]
---------------------------------
S
Q
K
L
V
I
Y
N
W
G
---
D
Y
I
D
P
E
L
L
T
Q
F
T
E
E
T
G
I
Q
V
Q
Y
E
T
F
D
S
N
E
A
M
Y
T
K
I
K
Q
-
G
-
G
T
T
Y
D
I
A
I
P
S
E
Y
M
I
N
K
M
K
D
E
D
L
L
V
P
L
D
Y
S
K
I
E
G
I
E
N
I
G
P
---
E
F
-
L
N
---
Q
---
S
F
D
P
G
N
K
F
S
I
P
Y
F
W
G
T
L
G
I
V
Y
N
----
E
T
-----
M
V
-
D
E
-----
A
---
P
E
H
W
D
D
L
W
K
L
----
E
-----
Y
K
N
-
S
-
I
M
-----
L
F
D
----
G
A
R
E
V
L
G
L
G
L
N
S
L
G
Y
S
L
N
S
K
D
P
-
Q
Q
L
-
E
E
-
T
V
D
K
L
Y
K
L
T
P
N
I
K
A
I
V
A
D
E
M
K
G
Y
-
M
I
Q
N
N
----
V
A
I
G
V
T
F
S
G
---
E
A
------
S
Q
M
L
E
------
K
N
E
---
N
------
L
R
Y
V
V
P
T
E
-
A
-
S
N
L
W
F
D
N
M
V
I
P
K
T
V
K
N
Q
D
S
A
Y
A
F
I
N
F
M
L
K
P
E
N
A
L
Q
N
A
E
Y
V
G
Y
S
T
P
N
L
P
A
K
E
L
L
P
E
E
T
K
E
D
K
A
F
Y
P
D
V
E
---
T
M
K
H
L
E
V
Y
E
K
F
D
H
K
W
T
G
K
Y
S
D
L
F
L
Q
F
K
M
Y
R
K
21
PsiBlast_CBE
87.75
60%
-96
- C1 -
4EQB
7
?
B:
[8-330]
---------------------------------
S
Q
K
L
V
I
Y
N
W
G
---
D
Y
I
D
P
E
L
L
T
Q
F
T
E
E
T
G
I
Q
V
Q
Y
E
T
F
D
S
N
E
A
M
Y
T
K
I
K
Q
-
G
-
G
T
T
Y
D
I
A
I
P
S
E
Y
M
I
N
K
M
K
D
E
D
L
L
V
P
L
D
Y
S
K
I
E
G
I
E
N
I
G
P
---
E
F
-
L
N
---
Q
---
S
F
D
P
G
N
K
F
S
I
P
Y
F
W
G
T
L
G
I
V
Y
N
----
E
T
-----
M
V
-
D
E
-----
A
---
P
E
H
W
D
D
L
W
K
L
----
E
-----
Y
K
N
-
S
-
I
M
-----
L
F
D
----
G
A
R
E
V
L
G
L
G
L
N
S
L
G
Y
S
L
N
S
K
D
P
-
Q
Q
L
-
E
E
-
T
V
D
K
L
Y
K
L
T
P
N
I
K
A
I
V
A
D
E
M
K
G
Y
-
M
I
Q
N
N
----
V
A
I
G
V
T
F
S
G
---
E
A
------
S
Q
M
L
E
------
K
N
E
---
N
------
L
R
Y
V
V
P
T
E
-
A
-
S
N
L
W
F
D
N
M
V
I
P
K
T
V
K
N
Q
D
S
A
Y
A
F
I
N
F
M
L
K
P
E
N
A
L
Q
N
A
E
Y
V
G
Y
S
T
P
N
L
P
A
K
E
L
L
P
E
E
T
K
E
D
K
A
F
Y
P
D
V
E
---
T
M
K
H
L
E
V
Y
E
K
F
D
H
K
W
T
G
K
Y
S
D
L
F
L
Q
F
K
M
Y
R
K
8
PsiBlast_PDB
74.92
34%
-86
- C1 -
3TTK
-
SPUD_PSEAE
A:
[29-348]
-----------------------------------
V
L
H
V
Y
N
W
S
---
D
Y
I
A
P
D
T
L
E
K
F
T
K
E
T
G
I
K
V
V
Y
D
V
Y
D
S
N
E
V
L
E
A
K
L
L
A
-
G
-
K
S
G
Y
D
V
V
V
P
S
N
S
F
L
A
K
Q
I
K
A
G
V
Y
Q
K
L
D
K
S
K
L
P
N
W
K
N
L
N
K
---
D
L
-
M
H
---
T
L
E-
V
S
D
P
G
N
E
H
A
I
P
Y
M
W
G
T
I
G
I
G
Y
N
P
D
K
V
K
A
-----
A
F
G
D
N
-----
A
P--
V
D
S
W
D
L
V
F
K
P
----
E
N
I
Q
K
-
L
K
Q
-
C
G
V
S
-----
F
L
D
----
S
P
T
E
I
L
P
A
A
L
H
Y
L
G
Y
K
P
D
T
D
N
P
-
K
E
L
-
K
A
-
A
E
E
L
F
L
K
I
R
P
Y
V
T
Y
F
H
S
S
K
Y
I
S
D
-
L
A
N
G
N
----
I
C
V
A
I
G
Y
S
G
---
D
I
------
Y
Q
A
K
S
------
R
A
E
---
E
A
KNK
V
T
V
K
Y
N
I
P
K
E
-
G
-
A
G
S
F
F
D
M
V
A
I
P
K
D
A
E
N
T
E
G
A
L
A
F
V
N
F
L
M
K
P
E
I
M
A
E
I
T
D
V
V
Q
F
P
N
G
N
A
A
A
T
P
L
V
S
E
A
I
R
N
D
P
G
I
Y
P
S
E
E
---
V
M
K
K
L
Y
T
F
P
D
L
--------------------
4
PsiBlast_PDB
74.56
36%
-84
- C1 -
3TTL
-
SPUE_PSEAE
A:
[28-362]
-----------------------------------
S
L
H
I
Y
N
W
T
---
D
Y
I
A
P
T
T
L
K
D
F
T
K
E
S
G
I
D
V
S
Y
D
V
F
D
S
N
E
T
L
E
G
K
L
V
S
-
G
-
H
S
G
Y
D
I
V
V
P
S
N
N
F
L
G
K
Q
I
Q
A
G
A
F
Q
K
L
D
K
S
K
L
P
N
W
K
N
L
D
P
A
L
L
K
Q
-
L
E
---
V
---
S
-
D
P
G
N
Q
Y
A
V
P
Y
L
W
G
T
N
G
I
G
Y
N
V
A
K
V
K
E
-----
V
L
G
D
Q
-----
P
---
I
D
S
W
A
I
L
F
E
P
----
E
N
M
K
K
L
A
K
C
-
G
-
V
A
-----
F
M
D
----
S
G
D
E
M
L
P
A
A
L
N
Y
L
G
L
D
P
N
T
H
D
P
-
K
D
Y
-
K
K
-
A
E
E
V
L
T
K
V
R
P
Y
V
S
Y
F
H
S
S
K
Y
I
S
D
-
L
A
N
G
N
----
I
C
V
A
F
G
Y
S
G
---
D
V
F
Q
A
A
A
R
A
E
E
A
G
------
K
G
I
---
D
------
I
Q
Y
V
I
P
K
E
-
G
-
A
N
L
W
F
D
L
M
A
I
P
A
D
A
K
A
A
D
N
A
Y
A
F
I
D
Y
L
L
R
P
E
V
I
A
K
V
S
D
Y
V
G
Y
A
N
A
I
P
G
A
R
P
L
M
D
K
S
V
S
D
S
E
E
V
Y
P
P
Q
A
---
V
L
D
K
L
Y
V
S
A
V
L
P
A
K
V
L
R
L
Q
T
R
T
W
T
R
I
K
----
3
PsiBlast_PDB
73.69
38%
-79
- C1 -
1POT
1
POTD_ECOLI
A:
[3-324]
---------------------------------
N
N
T
L
Y
F
Y
N
W
T
---
E
Y
V
P
P
G
L
L
E
Q
F
T
K
E
T
G
I
K
V
I
Y
S
T
Y
E
S
N
E
T
M
Y
A
K
L
K
T
Y
K
-
D
G
A
Y
D
L
V
V
P
S
T
Y
Y
V
D
K
M
R
K
E
G
M
I
Q
K
I
D
K
S
K
L
T
N
F
S
N
L
D
P
---
D
M
-
L
N
---
K
---
P
F
D
P
N
N
D
Y
S
I
P
Y
I
W
G
A
T
A
I
G
V
N
----
G
D
-----
A
V
D
P
K
-----
S
---
V
T
S
W
A
D
L
W
K
P
----
E
-----
Y
K
G
-
S
-
L
L
-----
L
T
D
----
D
A
R
E
V
F
Q
M
A
L
R
K
L
G
Y
S
G
N
T
T
D
P
-
K
E
I
-
E
A
-
A
Y
N
E
L
K
K
L
M
P
N
V
A
A
F
N
S
D
N
P
A
N
P
-
Y
M
E
G
E
----
V
N
L
G
M
I
W
N
G
---
S
A
------
F
V
A
R
Q
------
A
G
T
---
P
------
I
D
V
V
W
P
K
E
-
G
-
G
I
F
W
M
D
S
L
A
I
P
A
N
A
K
N
K
E
G
A
L
K
L
I
N
F
L
L
R
P
D
V
A
K
Q
V
A
E
T
I
G
Y
P
T
P
N
L
A
A
R
K
L
L
S
P
E
V
A
N
D
K
T
L
Y
P
D
A
E
---
T
I
K
N
G
E
W
Q
N
D
V
G
A
A
S
-
S
I
Y
E
E
Y
Y
Q
K
L
K
A
G
--
27
HHSearch
73.45
39%
-80
- C1 -
1POT
1
POTD_ECOLI
A:
[3-324]
---------------------------------
N
N
T
L
Y
F
Y
N
W
T
---
E
Y
V
P
P
G
L
L
E
Q
F
T
K
E
T
G
I
K
V
I
Y
S
T
Y
E
S
N
E
T
M
Y
A
K
L
K
T
-
Y
K
D
G
A
Y
D
L
V
V
P
S
T
Y
Y
V
D
K
M
R
K
E
G
M
I
Q
K
I
D
K
S
K
L
T
N
F
S
N
L
D
P
---
D
M
-
L
N
---
K
---
P
F
D
P
N
N
D
Y
S
I
P
Y
I
W
G
A
T
A
I
G
V
N
----
G
D
-----
A
V
D
P
K
-----
S
---
V
T
S
W
A
D
L
W
K
P
----
E
-----
Y
K
G
-
S
-
L
L
-----
L
T
D
----
D
A
R
E
V
F
Q
M
A
L
R
K
L
G
Y
S
G
N
T
T
D
P
-
K
E
I
-
E
A
-
A
Y
N
E
L
K
K
L
M
P
N
V
A
A
F
N
S
D
N
P
A
N
P
-
Y
M
E
G
E
----
V
N
L
G
M
I
W
N
G
---
S
A
------
F
V
A
R
Q
------
A
G
T
---
P
------
I
D
V
V
W
P
K
E
-
G
-
G
I
F
W
M
D
S
L
A
I
P
A
N
A
K
N
K
E
G
A
L
K
L
I
N
F
L
L
R
P
D
V
A
K
Q
V
A
E
T
I
G
Y
P
T
P
N
L
A
A
R
K
L
L
S
P
E
V
A
N
D
K
T
L
Y
P
D
A
E
---
T
I
K
N
G
E
W
Q
N
D
V
G
A
-
A
S
S
I
Y
E
E
Y
Y
Q
K
L
K
A
G
--
6
PsiBlast_PDB
72.11
35%
-87
- C1 -
4JDF
1
POTF_ECOLI
A:
[4-315]
---------------------------------
Q
K
T
L
H
I
Y
N
W
T
---
E
Y
I
A
P
D
T
V
A
N
F
E
K
E
T
G
I
K
V
V
Y
D
V
F
D
S
N
E
V
L
E
G
K
L
M
A
-
G
-
S
T
G
F
D
L
V
V
P
S
A
Y
F
L
E
R
Q
L
T
A
G
V
F
Q
P
L
D
K
S
K
L
P
E
W
K
N
L
D
P
---
E
L
-
L
K
---
L
V
A
-
K
H
D
P
D
N
K
F
A
M
P
Y
M
W
A
T
T
G
I
G
Y
N
----
V
D
K
V
K
A
V
L
G
E
N
A
-----
P
---
V
D
S
W
D
L
I
L
K
P
----
E
N
L
E
K
-
L
K
S
-
C
G
V
S
-----
F
L
D
----
D
P
E
E
V
F
A
T
V
L
N
Y
L
G
K
D
P
N
S
T
K
A
D
D
Y
T
-
G
P
-
A
T
D
L
L
L
K
L
R
P
N
I
R
Y
F
H
S
S
Q
Y
I
N
D
-
L
A
N
G
D
----
I
C
V
A
I
G
W
A
G
S
V
W
Q
A
------
S
N
R
A
K
------
E
A
K
NG
V
N
------
V
S
F
S
I
P
K
E
-
G
-
A
M
A
W
F
D
V
F
A
M
P
A
D
A
K
N
K
D
E
A
Y
Q
F
L
N
Y
L
L
R
P
D
V
V
A
H
I
S
D
H
V
F
Y
A
N
A
N
K
A
A
T
P
L
V
S
A
E
V
R
E
N
P
G
I
Y
P
P
A
D
----------------------------------
30
HHSearch
71.81
37%
-79
- C1 -
3TTN
1
SPUE_PSEAE
A:
[6-340]
-----------------------------------
S
L
H
I
Y
N
W
T
---
D
Y
I
A
P
T
T
L
K
D
F
T
K
E
S
G
I
D
V
S
Y
D
V
F
D
S
N
E
T
L
E
G
K
L
V
S
-
G
-
H
S
G
Y
D
I
V
V
P
S
N
N
F
L
G
K
Q
I
Q
A
G
A
F
Q
K
L
D
K
S
K
L
P
N
W
K
N
L
D
P
---
A
L
-
L
K
---
Q
L
EV
S
D
P
-
G
N
Q
Y
A
V
P
Y
L
W
G
T
N
G
I
G
Y
N
----
V
A
-----
K
V
K
E
V
L
----
G
DQP
I
D
S
W
A
I
L
F
E
P
E
N
M
K
K
-----
L
A
K
C
G
-
V
A
-----
F
M
D
----
S
G
D
E
M
L
P
A
A
L
N
Y
L
G
L
D
P
N
T
H
D
P
-
K
D
Y
-
K
K
-
A
E
E
V
L
T
K
V
R
P
Y
V
S
Y
F
H
S
S
K
Y
I
S
D
-
L
A
N
G
N
----
I
C
V
A
F
G
Y
S
G
---
D
V
------
F
Q
A
A
A
R
A
E
E
A
G
K
G
I
---
D
------
I
Q
Y
V
I
P
K
E
-
G
-
A
N
L
W
F
D
L
M
A
I
P
A
D
A
K
A
A
D
N
A
Y
A
F
I
D
Y
L
L
R
P
E
V
I
A
K
V
S
D
Y
V
G
Y
A
N
A
I
P
G
A
R
P
L
M
D
K
S
V
S
D
S
E
E
V
Y
P
P
Q
A
---
V
L
D
K
L
Y
V
S
A
V
L
P
A
K
V
L
R
L
Q
T
R
T
W
T
R
I
K
----
5
PsiBlast_PDB
70.46
36%
-77
- C1 -
3TTN
1
SPUE_PSEAE
A:
[6-340]
-----------------------------------
S
L
H
I
Y
N
W
T
---
D
Y
I
A
P
T
T
L
K
D
F
T
K
E
S
G
I
D
V
S
Y
D
V
F
D
S
N
E
T
L
E
G
K
L
V
S
-
G
-
H
S
G
Y
D
I
V
V
P
S
N
N
F
L
G
K
Q
I
Q
A
G
A
F
Q
K
L
D
K
S
K
L
P
N
W
K
N
L
D
P
A
L
L
K
Q
-
L
E
---
V
---
S
-
D
P
G
N
Q
Y
A
V
P
Y
L
W
G
T
N
G
I
G
Y
N
V
A
K
V
K
E
-----
V
L
G
D
Q
-----
P
---
I
D
S
W
A
I
L
F
E
P
----
E
N
M
K
K
L
A
K
C
-
G
-
V
A
-----
F
M
D
----
S
G
D
E
M
L
P
A
A
L
N
Y
L
G
L
D
P
N
T
H
D
P
-
K
D
Y
-
K
K
-
A
E
E
V
L
T
K
V
R
P
Y
V
S
Y
F
H
S
S
K
Y
I
S
D
-
L
A
N
G
N
----
I
C
V
A
F
G
Y
S
G
---
D
V
F
Q
A
A
A
R
A
E
E
A
G
------
K
G
I
---
D
------
I
Q
Y
V
I
P
K
E
-
G
-
A
N
L
W
F
D
L
M
A
I
P
A
D
A
K
A
A
D
N
A
Y
A
F
I
D
Y
L
L
R
P
E
V
I
A
K
V
S
D
Y
V
G
Y
A
N
A
I
P
G
A
R
P
L
M
D
K
S
V
S
D
S
E
E
V
Y
P
P
Q
A
---
V
L
D
K
L
Y
V
S
A
V
L
P
A
K
V
L
R
L
Q
T
R
T
W
T
R
I
K
----
29
HHSearch
69.90
30%
-83
* C1 *
2V84
7
?
A:
[25-342]
----------------------------------
D
V
L
Y
L
Y
N
W
T
---
Y
Y
T
P
T
S
L
I
K
K
F
E
Q
Q
Y
N
V
Q
V
V
Y
D
D
Y
A
S
N
E
D
M
F
A
K
L
S
I
-
G
-
A
S
G
Y
D
L
V
V
P
S
G
D
F
V
S
I
M
K
R
K
H
L
L
E
K
I
D
L
S
K
I
P
N
V
Q
F
I
K
E
---
S
V
-
R
A
---
R
I--
A
Y
D
P
K
M
E
Y
S
V
P
Y
Y
L
G
A
A
G
I
A
V
N
----
K
K
-----
A
V
P
S
------
Y
---
A
R
T
W
S
I
F
S
R
K
----
D
-----
L
A
Y
-
R
-
M
S
-----
M
M
D
----
D
M
R
E
V
M
G
A
A
L
A
S
L
G
Y
N
V
N
T
K
N
E
-
Q
E
L
-
A
Q
A
A
I
L
V
T
D
H
W
K
P
N
L
V
K
F
D
S
D
G
Y
A
K
S
-
F
A
S
G
D
----
F
V
V
A
H
G
F
A
E
---
A
F
------
F
A
E
T
P
EA----
M
H
E
---
H
------
I
D
F
F
I
P
Q
D
-
V
A
S
P
V
Y
V
D
S
F
C
I
P
K
G
A
R
N
R
D
L
A
H
A
F
I
N
F
F
L
E
P
A
H
Y
A
E
F
L
D
T
F
G
F
P
S
T
I
H
R
E
A
A
A
Y
Q
K
-----
K
T
P
Y
Y
S
E
H
---
D
L
E
R
G
T
L
K
T
D
V
G
A
-
A
I
E
H
Y
N
A
H
W
N
A
V
R
F
---
28
HHSearch
69.43
33%
-72
- C1 -
3TTM
1
SPUD_PSEAE
A:
[6-346]
--------------------------------
D
N
K
V
L
H
V
Y
N
W
S
---
D
Y
I
A
P
D
T
L
E
K
F
T
K
E
T
G
I
K
V
V
Y
D
V
Y
D
S
N
E
V
L
E
A
K
L
L
A
-
G
-
K
S
G
Y
D
V
V
V
P
S
N
S
F
L
A
K
Q
I
K
A
G
V
Y
Q
K
L
D
K
S
K
L
P
N
W
K
N
L
N
K
---
D
L
-
M
H
T
L
E
V
---
S
D
P
-
G
N
E
H
A
I
P
Y
M
W
G
T
I
G
I
G
Y
N
----
P
D
-----
K
V
K
A
A
F
GDNA
P
---
V
D
S
W
D
L
V
F
K
P
----
E
-----
N
I
Q
-
K
-
L
K
QC
G
V
S
F
L
D
----
S
P
T
E
I
L
P
A
A
L
H
Y
L
G
Y
K
P
D
T
D
N
P
-
K
E
L
-
K
A
-
A
E
E
L
F
L
K
I
R
P
Y
V
T
Y
F
H
S
S
K
Y
I
S
D
-
L
A
N
G
N
----
I
C
V
A
I
G
Y
S
G
---
D
I
------
Y
Q
A
K
S
R
A
E
E
A
K
N
K
V
---
T
------
V
K
Y
N
I
P
K
E
-
G
-
A
G
S
F
F
D
M
V
A
I
P
K
D
A
E
N
T
E
G
A
L
A
F
V
N
F
L
M
K
P
E
I
M
A
E
I
T
D
V
V
Q
F
P
N
G
N
A
A
A
T
P
L
V
S
E
A
I
R
N
D
P
G
I
Y
P
S
E
E
---
V
M
K
K
L
Y
T
F
P
D
L
P
A
K
T
Q
R
A
M
T
R
S
W
T
K
I
K
S
G
--
25
PsiBlast_CBE
69.17
34%
-77
- C1 -
3TTM
1
SPUD_PSEAE
B:
[9-328]
-----------------------------------
V
L
H
V
Y
N
W
S
---
D
Y
I
A
P
D
T
L
E
K
F
T
K
E
T
G
I
K
V
V
Y
D
V
Y
D
S
N
E
V
L
E
A
K
L
L
A
-
G
-
K
S
G
Y
D
V
V
V
P
S
N
S
F
L
A
K
Q
I
K
A
G
V
Y
Q
K
L
D
K
S
K
L
P
N
W
K
N
L
N
K
---
D
L
-
M
H
---
T
LE-
V
S
D
P
G
N
E
H
A
I
P
Y
M
W
G
T
I
G
I
G
Y
N
PDKV
K
A
-----
A
F
G
D
N
-----
A
P--
V
D
S
W
D
L
V
F
K
P
----
E
NIQKL
K
Q
C
-
G
-
V
S
-----
F
L
D
----
S
P
T
E
I
L
P
A
A
L
H
Y
L
G
Y
K
P
D
T
D
N
P
-
K
E
L
-
K
A
-
A
E
E
L
F
L
K
I
R
P
Y
V
T
Y
F
H
S
S
K
Y
I
S
D
-
L
A
N
G
N
----
I
C
V
A
I
G
Y
S
G
---
D
I
------
Y
Q
A
K
S
------
R
A
E
---
E
AKNKVT
V
K
Y
N
I
P
K
E
-
G
-
A
G
S
F
F
D
M
V
A
I
P
K
D
A
E
N
T
E
G
A
L
A
F
V
N
F
L
M
K
P
E
I
M
A
E
I
T
D
V
V
Q
F
P
N
G
N
A
A
A
T
P
L
V
S
E
A
I
R
N
D
P
G
I
Y
P
S
E
E
---
V
M
K
K
L
Y
T
F
P
D
L
--------------------
9
PsiBlast_PDB
69.03
34%
-75
- C1 -
3TTM
1
SPUD_PSEAE
A:
[9-328]
-----------------------------------
V
L
H
V
Y
N
W
S
---
D
Y
I
A
P
D
T
L
E
K
F
T
K
E
T
G
I
K
V
V
Y
D
V
Y
D
S
N
E
V
L
E
A
K
L
L
A
-
G
-
K
S
G
Y
D
V
V
V
P
S
N
S
F
L
A
K
Q
I
K
A
G
V
Y
Q
K
L
D
K
S
K
L
P
N
W
K
N
L
N
K
---
D
L
-
M
H
---
T
L
E-
V
S
D
P
G
N
E
H
A
I
P
Y
M
W
G
T
I
G
I
G
Y
N
P
D
K
V
K
A
-----
A
F
G
D
N
-----
A
P--
V
D
S
W
D
L
V
F
K
P
----
E
N
I
Q
K
L
K
Q
C
-
G
-
V
S
-----
F
L
D
----
S
P
T
E
I
L
P
A
A
L
H
Y
L
G
Y
K
P
D
T
D
N
P
-
K
E
L
-
K
A
-
A
E
E
L
F
L
K
I
R
P
Y
V
T
Y
F
H
S
S
K
Y
I
S
D
-
L
A
N
G
N
----
I
C
V
A
I
G
Y
S
G
---
D
I
------
Y
Q
A
K
S
------
R
A
E
---
E
A
KNK
V
T
V
K
Y
N
I
P
K
E
-
G
-
A
G
S
F
F
D
M
V
A
I
P
K
D
A
E
N
T
E
G
A
L
A
F
V
N
F
L
M
K
P
E
I
M
A
E
I
T
D
V
V
Q
F
P
N
G
N
A
A
A
T
P
L
V
S
E
A
I
R
N
D
P
G
I
Y
P
S
E
E
---
V
M
K
K
L
Y
T
F
P
D
L
--------------------
22
PsiBlast_CBE
67.27
35%
-71
- C1 -
1A99
1
POTF_ECOLI
D:
[3-326]
---------------------------------
Q
K
T
L
H
I
Y
N
W
S
---
D
Y
I
A
P
D
T
V
A
N
F
E
K
E
T
G
I
K
V
V
Y
D
V
F
D
S
N
E
V
L
E
G
K
L
M
A
-
G
-
S
T
G
F
D
L
V
V
P
S
A
S
F
L
E
R
Q
L
T
A
G
V
F
Q
P
L
D
K
S
K
L
P
E
W
K
N
L
D
P
---
E
L
-
L
K
---
L
VA-
K
H
D
P
D
N
K
F
A
M
P
Y
M
W
A
T
T
G
I
G
Y
N
----
V
D
KVKAV
L
G
E
N
A
-----
P
---
V
D
S
W
D
L
I
L
K
P
----
E
NLEK-
L
K
S
-
C
G
V
S
-----
F
L
D
----
A
P
E
E
V
F
A
T
V
L
N
Y
L
G
K
D
P
N
S
T
K
A
D
D
Y
T
-
G
P
-
A
T
D
L
L
L
K
L
R
P
N
I
R
Y
F
H
S
S
Q
Y
I
N
D
-
L
A
N
G
D
----
I
C
V
A
I
G
W
A
G
---
D
V
WQASNR
A
K
E
A
K
------
N
G
V
---
N
------
V
S
F
S
I
P
K
E
-
G
-
A
M
A
F
F
D
V
F
A
M
P
A
D
A
K
N
K
D
E
A
Y
Q
F
L
N
Y
L
L
R
P
D
V
V
A
H
I
S
D
H
V
F
Y
A
N
A
N
K
A
A
T
P
L
V
S
A
E
V
R
E
N
P
G
I
Y
P
P
A
D
VRA
K
L
F
T
L
K
V
Q
D
----------------------
7
PsiBlast_PDB
66.71
35%
-71
- C1 -
1A99
1
POTF_ECOLI
A:
[3-326]
---------------------------------
Q
K
T
L
H
I
Y
N
W
S
---
D
Y
I
A
P
D
T
V
A
N
F
E
K
E
T
G
I
K
V
V
Y
D
V
F
D
S
N
E
V
L
E
G
K
L
M
A
-
G
-
S
T
G
F
D
L
V
V
P
S
A
S
F
L
E
R
Q
L
T
A
G
V
F
Q
P
L
D
K
S
K
L
P
E
W
K
N
L
D
P
---
E
L
-
L
K
---
L
V
A
-
K
H
D
P
D
N
K
F
A
M
P
Y
M
W
A
T
T
G
I
G
Y
N
----
V
D
K
V
K
A
V
L
G
E
N
A
-----
P
---
V
D
S
W
D
L
I
L
K
P
----
E
N
L
E
K
-
L
K
S
-
C
G
V
S
-----
F
L
D
----
A
P
E
E
V
F
A
T
V
L
N
Y
L
G
K
D
P
N
S
T
K
A
D
D
Y
T
-
G
P
-
A
T
D
L
L
L
K
L
R
P
N
I
R
Y
F
H
S
S
Q
Y
I
N
D
-
L
A
N
G
D
----
I
C
V
A
I
G
W
A
G
---
D
V
W
Q
A
S
N
R
A
K
E
A
K
------
N
G
V
---
N
------
V
S
F
S
I
P
K
E
-
G
-
A
M
A
F
F
D
V
F
A
M
P
A
D
A
K
N
K
D
E
A
Y
Q
F
L
N
Y
L
L
R
P
D
V
V
A
H
I
S
D
H
V
F
Y
A
N
A
N
K
A
A
T
P
L
V
S
A
E
V
R
E
N
P
G
I
Y
P
P
A
D
V
R
A
K
L
F
T
L
K
V
Q
D
----------------------
24
PsiBlast_CBE
65.52
35%
-69
- C1 -
1A99
1
POTF_ECOLI
B:
[3-326]
---------------------------------
Q
K
T
L
H
I
Y
N
W
S
---
D
Y
I
A
P
D
T
V
A
N
F
E
K
E
T
G
I
K
V
V
Y
D
V
F
D
S
N
E
V
L
E
G
K
L
M
A
-
G
-
S
T
G
F
D
L
V
V
P
S
A
S
F
L
E
R
Q
L
T
A
G
V
F
Q
P
L
D
K
S
K
L
P
E
W
K
N
L
D
P
---
E
L
-
L
K
---
L
VA-
K
H
D
P
D
N
K
F
A
M
P
Y
M
W
A
T
T
G
I
G
Y
N
----
V
D
KVKAV
L
G
E
N
A
-----
P
---
V
D
S
W
D
L
I
L
K
P
----
E
NLEK-
L
K
S
-
C
G
V
S
-----
F
L
D
----
A
P
E
E
V
F
A
T
V
L
N
Y
L
G
K
D
P
N
S
T
K
A
D
D
Y
T
-
G
P
-
A
T
D
L
L
L
K
L
R
P
N
I
R
Y
F
H
S
S
Q
Y
I
N
D
-
L
A
N
G
D
----
I
C
V
A
I
G
W
A
G
---
D
V
WQASNR
A
K
E
A
K
------
N
G
V
---
N
------
V
S
F
S
I
P
K
E
-
G
-
A
M
A
F
F
D
V
F
A
M
P
A
D
A
K
N
K
D
E
A
Y
Q
F
L
N
Y
L
L
R
P
D
V
V
A
H
I
S
D
H
V
F
Y
A
N
A
N
K
A
A
T
P
L
V
S
A
E
V
R
E
N
P
G
I
Y
P
P
A
D
VRA
K
L
F
T
L
K
V
Q
D
----------------------
23
PsiBlast_CBE
65.47
35%
-73
- C1 -
1A99
1
POTF_ECOLI
C:
[3-326]
---------------------------------
Q
K
T
L
H
I
Y
N
W
S
---
D
Y
I
A
P
D
T
V
A
N
F
E
K
E
T
G
I
K
V
V
Y
D
V
F
D
S
N
E
V
L
E
G
K
L
M
A
-
G
-
S
T
G
F
D
L
V
V
P
S
A
S
F
L
E
R
Q
L
T
A
G
V
F
Q
P
L
D
K
S
K
L
P
E
W
K
N
L
D
P
---
E
L
-
L
K
---
L
VA-
K
H
D
P
D
N
K
F
A
M
P
Y
M
W
A
T
T
G
I
G
Y
N
----
V
D
KVKAV
L
G
E
N
A
-----
P
---
V
D
S
W
D
L
I
L
K
P
----
E
NLEK-
L
K
S
-
C
G
V
S
-----
F
L
D
----
A
P
E
E
V
F
A
T
V
L
N
Y
L
G
K
D
P
N
S
T
K
A
D
D
Y
T
-
G
P
-
A
T
D
L
L
L
K
L
R
P
N
I
R
Y
F
H
S
S
Q
Y
I
N
D
-
L
A
N
G
D
----
I
C
V
A
I
G
W
A
G
---
D
V
WQASNR
A
K
E
A
K
------
N
G
V
---
N
------
V
S
F
S
I
P
K
E
-
G
-
A
M
A
F
F
D
V
F
A
M
P
A
D
A
K
N
K
D
E
A
Y
Q
F
L
N
Y
L
L
R
P
D
V
V
A
H
I
S
D
H
V
F
Y
A
N
A
N
K
A
A
T
P
L
V
S
A
E
V
R
E
N
P
G
I
Y
P
P
A
D
VRA
K
L
F
T
L
K
V
Q
D
----------------------
10
PsiBlast_PDB
63.43
35%
-91
- C1 -
2V84
6
?
A:
[25-286]
----------------------------------
D
V
L
Y
L
Y
N
W
T
---
Y
Y
T
P
T
S
L
I
K
K
F
E
Q
Q
Y
N
V
Q
V
V
Y
D
D
Y
A
S
N
E
D
M
F
A
K
L
S
I
-
G
-
A
S
G
Y
D
L
V
V
P
S
G
D
F
V
S
I
M
K
R
K
H
L
L
E
K
I
D
L
S
K
I
P
N
V
Q
F
I
K
E
---
S
V
R
A
R
---
I
---
A
Y
D
P
K
M
E
Y
S
V
P
Y
Y
L
G
A
A
G
I
A
V
N
----
K
K
-----
A
V
P
S
Y
-----
A
----
R
T
W
S
I
F
S
R
K
----
D
-----
L
A
Y
-
R
-
M
S
-----
M
M
D
----
D
M
R
E
V
M
G
A
A
L
A
S
L
G
Y
N
V
N
T
K
N
E
-
Q
E
L
A
Q
A
-
A
I
L
V
T
D
H
W
K
P
N
L
V
K
F
D
S
D
G
Y
A
K
S
-
F
A
S
G
D
FV
V
A
H
G
F
A
E
A
F
F
A
---
E
T
------
P
E
A
M
H
------
E
H
-----------
I
D
F
F
I
P
Q
D
V
A
-
S
P
V
Y
V
D
S
F
C
I
P
K
G
A
R
N
R
D
L
A
H
A
F
I
N
F
F
L
E
P
A
H
Y
A
--------------------------------------------------------------------
11
PsiBlast_PDB
54.96
24%
-82
- C1 -
4EDP
6
?
A:
[36-290]
-----------------------------------
K
L
V
V
S
T
W
G
LN
E
D
V
L
K
E
T
V
F
E
P
F
A
K
E
H
G
V
E
I
V
L
D
I
G
N
N
S
E
R
L
T
K
M
K
N
N
-
P
-
N
S
Q
I
D
I
T
Y
L
A
E
S
F
A
E
Q
G
V
E
A
G
I
F
D
K
L
D
Y
S
K
I
P
N
A
S
E
M
N
E
---
K
A
-
K
S
---
T
---
V
---
E
A
G
Y
G
P
A
Y
T
L
N
S
I
G
I
V
V
D
----
P
S
-----
A
G
I
E
I
-----
N
-----
S
W
E
D
L
W
K
P
----
E
-----
L
K
N
-
K
-
I
A
-----
I
P
D
ITTT
N
G
P
A
M
V
E
I
A
A
E
K
A
G
V
D
V
K
T
D
N
G
-----
E
A
-
A
F
K
E
L
E
A
L
K
P
N
V
V
K
T
Y
S
K
S
S
D
L
A
N
M
F
S
N
G
----
E
I
V
A
A
V
A
S
D
---
F
A
------
F
G
T
I
S
------
K
A
K
P--
E
------
V
I
N
V
I
P
E
S
-
G
-
T
Y
L
N
F
N
T
I
N
I
N
K
N
S
K
N
K
D
L
A
Y
E
F
I
N
Y
A
L
S
K
E
-----------------------------------------------------------------------