@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1363: (2016-03-23 )
LQDLTLFLEQYKKVIDESLFKEINERNIEPRLKESMLYSIQAGGKRIRPMLVFATLQALKVNPLLGVKTATALEMIHTYSLIHDDLPAMDNDDYRRGKWTNHKVFGDATAILAGDALLTLAFSILAEDDNLSFETRIALINQISFSSGAEGMVGGQLADLEAENKQVTLEELSSIHARKTGELLIYAVTSAAKIAEADPEQTKRLRIFAENIGIGFQISDDILDVIGDETKMGKKTGADAFLNKSTYPGLLTLDGAKRALNEHVTIAKSALSGHDFDDEILLKLADLIALREN
Atome Classification :
(54 SA)
.........10......---..20--....---.--.-..30-----.--........40........50....--....------60.--...--....70........80........90........100.......110..--------.....120.......--130-.--.--....--.-.--140--.......150..--.....160..---..--..--.170.......180.......-190...-..--..-200..----.....210.......220.......230.......240.......250.....-.---.260.......270-.....---....280.......290.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
L
Q
D
L
T
L
F
L
E
Q
Y
K
K
V
I
D
E
---
S
L
F
K
--
E
I
N
E---R--N-I
E
P
------
R
--
L
K
E
S
M
L
Y
SIQAGGKR
I
R
P
M
L
V
F
A
T
--
L
Q
A
L------KVN--PLL--GV
K
T
A
T
A
L
E
M
I
H
T
Y
S
L
I
HDDLPAMDNDDYRRGKWTNHKVFGD
A
T
A
I
LAG--------
D
A
L
L
T
L
A
F
S
I
LAEDD--NL--
S
--
F
--
E
T
R
I
--
A
-
L
--
I
N
Q
--
I
SFSSGAEGMVG--
G
Q
L
ADLEAEN---K
Q
--
V
T
--
L
E
E
L
S
S
I
H
ARKTG
E
L
L
I
Y
A
VT-S
A
A
KIA-EA--
D
P
-
E
Q
T
K
R
----
L
R
I
F
A
ENI
G
I
G
F
Q
I
S
D
D
I
L
D
VIGDETKMGKKTGA
D
A
FLNKSTYP
G
L
L
T
L
D
G
A
K
-
R
---
A
L
N
E
H
V
T
I
A
K
S
A---LSGHD---F
D
D
E
I
L
L
K
L
A
D
L
I
ALREN
1
PsiBlast_PDB
97.58
52%
-87
- C1 -
1RTR
-
?
A:
[8-291]
------------
K
L
I
D
E
V
N
N
E
L
S
V
--
A
I
N
K
---
S
--
V
-
M
D
T
------
Q
--
L
E
E
S
M
L
Y
S
L
N
A
G
G
K
R
I
R
P
V
L
L
L
L
T
--
L
D
S
L
------
N
T
E
--
Y
E
L
--
G
M
K
S
A
I
A
L
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
K
L
T
N
H
K
V
Y
G
E
W
T
A
I
L
A
G
--------
D
A
L
L
T
K
A
F
E
L
I
S
S
D
D
--
R
L
--
T
--
D
--
E
V
K
I
--
K
-
V
--
L
Q
R
--
L
S
I
A
S
G
H
V
G
M
V
G
--
G
Q
M
L
D
M
Q
S
E
G
---
Q
P
--
I
D
--
L
E
T
L
E
M
I
H
K
T
K
T
G
A
L
L
T
F
A
V
M
-
S
A
A
D
I
A
-
N
V
--
D
D
-
T
T
K
E
H
----
L
E
S
Y
S
Y
H
L
G
M
M
F
Q
I
K
D
D
L
L
D
C
Y
G
D
E
A
-------------
K
S
T
Y
V
S
L
L
G
K
D
G
A
E
-
D
---
K
L
T
Y
H
R
D
A
A
V
D
E
---
L
T
Q
I
D
EQ-
F
N
T
K
H
L
L
E
I
V
D
L
F
Y
S
R
--
108
HHSearch
97.53
51%
-87
- C1 -
1RTR
-
?
A:
[7-291]
--------
N
K
L
I
D
E
V
N
N
---
E
L
S
V
--
A
I
N
K
---
S
--
V
-
M
D
T
------
Q
--
L
E
E
S
M
L
Y
S
L
N
A
G
G
K
R
I
R
P
V
L
L
L
L
T
--
L
D
S
L
------
N
T
E
--
Y
E
L
--
G
M
K
S
A
I
A
L
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
K
L
T
N
H
K
V
Y
G
E
W
T
A
I
L
A
G
--------
D
A
L
L
T
K
A
F
E
L
I
S
S
D
D
--
R
L
--
T
--
D
--
E
V
K
I
--
K
-
V
--
L
Q
R
--
L
S
I
A
S
G
H
V
G
M
V
G
--
G
Q
M
L
D
M
Q
S
E
G
---
Q
P
--
I
D
--
L
E
T
L
E
M
I
H
K
T
K
T
G
A
L
L
T
F
A
V
M
-
S
A
A
D
I
A
-
N
V
--
D
D
-
T
T
K
E
H
----
L
E
S
Y
S
Y
H
L
G
M
M
F
Q
I
K
D
D
L
L
D
C
Y
G
D
E
A
-------------
K
S
T
Y
V
S
L
L
G
K
D
G
A
E
-
D
---
K
L
T
Y
H
R
D
A
A
V
D
E
---
L
T
Q
I
D
EQ-
F
N
T
K
H
L
L
E
I
V
D
L
F
Y
S
R
--
36
PsiBlast_CBE
95.17
43%
-80
- C1 -
3TS7
3
?
B:
[7-302]
-
R
S
L
S
D
F
M
R
S
S
Q
E
R
V
E
R
---
A
L
D
A
--
R
L
P
A
---
A
--
D
-
R
M
P
E
-----
R
--
L
H
Q
A
M
R
Y
S
V
L
G
G
G
K
R
M
R
P
L
L
T
Y
A
T
--
G
Q
T
I
------
G
V
A
--
A
D
L
--
L
D
G
P
A
C
A
V
E
F
I
H
V
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
C
H
K
A
Y
D
E
A
T
A
I
L
A
G
--------
D
G
L
Q
A
L
A
F
H
V
L
A
Q
D
P
--
S
I
--
A
--
V
P
A
E
N
R
I
--
A
-
M
--
I
E
T
--
L
A
K
A
S
G
P
A
G
M
V
G
--
G
Q
A
I
D
L
A
S
V
G
---
K
K
--
L
D
--
L
P
G
L
E
N
M
H
I
R
K
T
G
A
L
I
R
A
S
V
R
-
L
A
C
L
A
R
-
P
G
--
L
P
A
E
Q
F
D
R
----
L
D
H
Y
A
K
C
I
G
L
A
F
Q
I
Q
D
D
I
L
D
E
E
S
D
T
Q
T
L
-----------
K
P
N
Y
P
A
L
L
G
L
S
G
A
K
-
E
---
K
A
E
E
M
H
E
A
A
L
E
S
---
L
A
G
F
G
---
P
E
A
D
L
L
R
E
L
A
R
F
I
I
Q
R
Q
S
16
PsiBlast_PDB
92.81
43%
-79
- C1 -
3TS7
2
?
A:
[7-302]
-
R
S
L
S
D
F
M
R
S
S
Q
E
R
V
E
R
---
A
L
D
A
--
R
L
P
A
---
A
--
D
-
R
M
P
E
-----
R
--
L
H
Q
A
M
R
Y
S
V
L
G
G
G
K
R
M
R
P
L
L
T
Y
A
T
--
G
Q
T
I
------
G
V
A
--
A
D
L
--
L
D
G
P
A
C
A
V
E
F
I
H
V
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
C
H
K
A
Y
D
E
A
T
A
I
L
A
G
--------
D
G
L
Q
A
L
A
F
H
V
L
A
Q
D
P
--
S
I
--
A
--
V
P
A
E
N
R
I
--
A
-
M
--
I
E
T
--
L
A
K
A
S
G
P
A
G
M
V
G
--
G
Q
A
I
D
L
A
S
V
G
---
K
K
--
L
D
--
L
P
G
L
E
N
M
H
I
R
K
T
G
A
L
I
R
A
S
V
R
-
L
A
C
L
A
R
-
P
G
--
L
P
A
E
Q
F
D
R
----
L
D
H
Y
A
K
C
I
G
L
A
F
Q
I
Q
D
D
I
L
D
E
E
S
D
---------------
K
P
N
Y
P
A
L
L
G
L
S
G
A
K
-
E
---
K
A
E
E
M
H
E
A
A
L
E
S
---
L
A
G
F
G
---
P
E
A
D
L
L
R
E
L
A
R
F
I
I
Q
R
Q
S
101
HHSearch
92.80
44%
-83
- C1 -
3TS7
2
?
A:
[8-301]
--
S
L
S
D
F
M
R
S
S
Q
E
R
V
E
R
---
A
L
D
A
--
R
L
-
P
---
A
AD
R
-
M
P
E
------
R
--
L
H
Q
A
M
R
Y
S
V
L
G
G
G
K
R
M
R
P
L
L
T
Y
A
T
--
G
Q
T
I
------
G
V
A
--
A
D
L
--
L
D
G
P
A
C
A
V
E
F
I
H
V
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
C
H
K
A
Y
D
E
A
T
A
I
L
A
G
--------
D
G
L
Q
A
L
A
F
H
V
L
A
Q
D
P
--
S
I
AV
P
--
A
--
E
N
R
I
--
A
-
M
--
I
E
T
--
L
A
K
A
S
G
P
A
G
M
V
G
--
G
Q
A
I
D
L
A
S
V
G
---
K
K
--
L
D
--
L
P
G
L
E
N
M
H
I
R
K
T
G
A
L
I
R
A
S
V
R
-
L
A
C
L
A
R
P
G
L
--
P
A
-
E
Q
F
D
R
----
L
D
H
Y
A
K
C
I
G
L
A
F
Q
I
Q
D
D
I
L
D
E
E
S
D
---------------
K
P
N
Y
P
A
L
L
G
L
S
G
A
K
-
E
---
K
A
E
E
M
H
E
A
A
L
E
S
---
L
A
G
F
G
---
P
E
A
D
L
L
R
E
L
A
R
F
I
I
Q
R
Q
-
38
PsiBlast_CBE
90.43
45%
-70
- C1 -
1RQJ
5
ISPA_ECOLI
B:
[8-297]
----------------
E
---
A
C
V
K
--
Q
A
N
Q
A
L
S
R
--
F
-
I
A
P
LPFQNT
P
--
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
--
G
H
M
F
------
G
V
S
--
T
N
T
--
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
--------
D
A
L
Q
T
L
A
F
S
I
L
S
D
A
D
MP
E
V
--
S
--
D
--
R
D
R
I
--
S
-
M
--
I
S
E
--
L
A
S
A
S
G
I
A
G
M
C
G
--
G
Q
A
L
D
L
D
A
E
G
---
K
H
--
V
P
--
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
-
L
G
A
L
S
A
-
G
------
D
K
G
R
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
-
K
---
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
A
E
Q
S
---
L
D
T
S
A
L
E
A
L
A
D
Y
I
I
Q
R
--
21
PsiBlast_CBE
90.41
45%
-69
- C1 -
4LFG
5
?
B:
[6-274]
------------
K
K
I
D
Q
---
T
I
H
A
--
F
Y
C
E
---
K
--
A
V
I
S
E
------
K
--
L
N
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
--
I
E
A
L
------
Q
I
---
P
L
T
E
S
H
F
K
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
--------
D
S
L
F
L
D
A
F
G
M
L
A
E
T
D
---
F
--
P
--
T
--
D
V
T
V
--
D
-
L
--
V
R
S
--
L
S
S
A
S
G
T
F
G
M
V
G
--
G
Q
M
L
D
M
A
A
E
G
---
K
K
--
L
N
--
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
L
A
Y
P
F
W
-
A
A
A
R
V
A
-
Q
L
--
D
E
-
N
L
L
A
T
----
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
Y
-
Q
---
I
L
D
E
S
L
D
Q
A
E
A
----------------
I
L
R
K
L
S
D
E
I
A
F
---
103
HHSearch
90.21
41%
-73
- C1 -
3PDE
5
?
A:
[6-298]
-
A
R
L
I
A
F
E
D
Q
W
V
P
A
L
N
A
---
P
L
K
Q
--
A
I
-
L
---
A
D
-
S
-
Q
D
A
------
Q
--
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
--
M
Q
S
L
------
G
V
T
F
V
P
E
R
--
H
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
--------
D
G
L
L
T
L
A
F
Q
W
L
T
A
T
D
--
L
P
-----
A
--
T
M
Q
A
--
A
-
L
--
V
Q
A
--
L
A
T
A
A
G
P
S
G
M
V
A
--
G
Q
A
K
D
I
Q
S
E
H
---
V
N
--
L
P
--
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
-
A
G
L
I
L
G
-
Q
A
--
P
E
-
A
Q
W
P
A
----
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
-----------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
-
Q
---
A
L
I
D
T
I
H
S
G
Q
A
A
---
L
Q
G
L
P
TS-
T
Q
R
D
D
L
A
A
F
F
S
Y
F
D
T
E
--
37
PsiBlast_CBE
90.17
45%
-72
- C1 -
1RQI
5
ISPA_ECOLI
B:
[9-298]
----------------
E
---
A
C
V
K
--
Q
A
N
Q
A
L
S
R
--
F
-
I
A
P
LPFQNT
P
--
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
--
G
H
M
F
------
G
V
S
--
T
N
T
--
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
--------
D
A
L
Q
T
L
A
F
S
I
L
S
D
A
D
MP
E
V
--
S
--
D
--
R
D
R
I
--
S
-
M
--
I
S
E
--
L
A
S
A
S
G
I
A
G
M
C
G
--
G
Q
A
L
D
L
D
A
E
G
---
K
H
--
V
P
--
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
-
L
G
A
L
S
A
-
G
------
D
K
G
R
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
-
K
---
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
A
E
Q
S
---
L
D
T
S
A
L
E
A
L
A
D
Y
I
I
Q
R
--
17
PsiBlast_PDB
89.98
45%
-71
- C1 -
1RQI
6
ISPA_ECOLI
A:
[9-298]
----------------
E
---
A
C
V
K
--
Q
A
N
Q
A
L
S
R
--
F
-
I
A
P
LPFQNT
P
--
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
--
G
H
M
F
------
G
V
S
--
T
N
T
--
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
--------
D
A
L
Q
T
L
A
F
S
I
L
S
D
A
D
MP
E
V
--
S
--
D
--
R
D
R
I
--
S
-
M
--
I
S
E
--
L
A
S
A
S
G
I
A
G
M
C
G
--
G
Q
A
L
D
L
D
A
E
G
---
K
H
--
V
P
--
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
-
L
G
A
L
S
A
-
G
------
D
K
G
R
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
-
K
---
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
A
E
Q
S
---
L
D
T
S
A
L
E
A
L
A
D
Y
I
I
Q
R
--
2
PsiBlast_PDB
89.89
45%
-84
- C1 -
4LFE
3
?
A:
[6-274]
------------
K
K
I
D
Q
---
T
I
H
A
--
F
Y
C
E
---
K
--
A
V
I
S
E
------
K
--
L
N
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
--
I
E
A
L
------
Q
I
---
P
L
T
E
S
H
F
K
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
--------
D
S
L
F
L
D
A
F
G
M
L
A
E
T
D
---
F
--
P
--
T
--
D
V
T
V
--
D
-
L
--
V
R
S
--
L
S
S
A
S
G
T
F
G
M
V
G
--
G
Q
M
L
D
M
A
A
E
G
---
K
K
--
L
N
--
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
L
A
Y
P
F
W
-
A
A
A
R
V
A
-
Q
L
--
D
E
-
N
L
L
A
T
----
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
----------------
K
M
T
Y
P
H
L
L
G
L
N
E
S
Y
-
Q
---
I
L
D
E
S
L
D
Q
A
E
A
----------------
I
L
R
K
L
S
D
E
I
A
F
---
104
HHSearch
89.80
40%
-80
- C1 -
3LSN
3
?
A:
[2-293]
--
S
L
T
A
Y
Q
A
S
S
Q
A
R
V
D
A
---
A
M
H
T
--
L
F
T
A
---
P
S-
P
-
E
L
A
------
R
--
L
Y
E
A
M
R
Y
S
V
M
N
G
G
K
R
V
R
P
L
L
A
Y
A
A
--
C
E
A
L
------
G
G
K
--
P
E
Q
--
A
N
G
A
A
C
A
V
E
L
I
H
A
Y
S
L
V
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
Q
P
T
T
H
K
A
F
D
E
A
C
A
I
L
A
G
--------
D
G
L
Q
S
L
A
F
S
A
L
L
D
P
A
--
L
S
DA
S
--
A
--
E
I
R
L
--
R
-
M
--
V
T
T
--
L
A
Q
A
A
G
P
A
G
M
V
G
--
G
Q
A
I
D
L
G
S
V
G
---
L
K
--
L
D
--
Q
Q
A
L
E
Y
M
H
R
H
K
T
G
A
L
I
E
A
S
V
I
-
L
G
A
L
A
S
-
G
R
--
A
E
K
G
E
L
K
A
----
L
Q
T
Y
A
Q
A
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
E
S
D
T
A
T
L
------------
P
T
Y
P
A
L
L
G
L
A
A
A
K
-
E
---
Y
A
L
E
L
R
D
Q
A
L
H
A
---
L
R
P
F
D
---
A
A
A
E
P
L
R
E
L
A
R
Y
I
V
E
---
106
HHSearch
89.75
45%
-61
- C1 -
1RQJ
5
ISPA_ECOLI
A:
[2-299]
--
D
F
P
Q
Q
L
E
A
C
V
K
Q
A
N
Q
---
A
L
S
R
--
F
I
A
P
L--
P
--
F
-
Q
N
T
------
P
--
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
--
G
H
M
F
------
G
V
S
--
T
N
T
--
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
--------
D
A
L
Q
T
L
A
F
S
I
L
S
D
A
D
--
M
P
--
E
VS
D
--
R
D
R
I
--
S
-
M
--
I
S
E
--
L
A
S
A
S
G
I
A
G
M
C
G
--
G
Q
A
L
D
L
D
A
E
G
---
K
H
--
V
P
--
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
-
L
G
A
L
S
A
-
G
D
--
K
G
R
R
A
L
P
V
----
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
-
K
---
K
A
R
D
L
I
D
D
A
R
Q
S
---
L
K
Q
L
A
E
Q
S
L
D
T
S
A
L
E
A
L
A
D
Y
I
I
Q
R
N
K
18
PsiBlast_PDB
89.45
45%
-69
- C1 -
1RQJ
5
ISPA_ECOLI
A:
[8-297]
----------------
E
---
A
C
V
K
--
Q
A
N
Q
A
L
S
R
--
F
-
I
A
P
LPFQNT
P
--
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
--
G
H
M
F
------
G
V
S
--
T
N
T
--
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
--------
D
A
L
Q
T
L
A
F
S
I
L
S
D
A
D
MP
E
V
--
S
--
D
--
R
D
R
I
--
S
-
M
--
I
S
E
--
L
A
S
A
S
G
I
A
G
M
C
G
--
G
Q
A
L
D
L
D
A
E
G
---
K
H
--
V
P
--
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
-
L
G
A
L
S
A
-
G
------
D
K
G
R
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
Q
A
R
-
K
---
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
A
E
Q
S
---
L
D
T
S
A
L
E
A
L
A
D
Y
I
I
Q
R
--
22
PsiBlast_CBE
89.31
45%
-69
- C1 -
4LFE
5
?
B:
[6-274]
------------
K
K
I
D
Q
---
T
I
H
A
--
F
Y
C
E
---
K
--
A
V
I
S
E
------
K
--
L
N
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
--
I
E
A
L
------
Q
I
---
P
L
T
E
S
H
F
K
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
--------
D
S
L
F
L
D
A
F
G
M
L
A
E
T
D
---
F
--
P
--
T
--
D
V
T
V
--
D
-
L
--
V
R
S
--
L
S
S
A
S
G
T
F
G
M
V
G
--
G
Q
M
L
D
M
A
A
E
G
---
K
K
--
L
N
--
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
L
A
Y
P
F
W
-
A
A
A
R
V
A
-
Q
L
--
D
E
-
N
L
L
A
T
----
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
Y
-
Q
---
I
L
D
E
S
L
D
Q
A
E
A
----------------
I
L
R
K
L
S
D
E
I
A
F
---
28
PsiBlast_CBE
89.14
40%
-83
- C1 -
4KKM
3
?
B:
[26-316]
--
N
L
K
T
M
M
E
Q
V
A
Q
D
I
D
R
----
L
F
A
--
E
Q
L
P
---
V
--
P
-
E
D
P
------
R
RR
L
V
E
A
M
R
Y
A
A
I
G
G
G
K
R
L
R
P
L
L
V
V
A
T
--
C
A
L
F
------
N
V
D
--
R
E
A
--
A
L
R
V
G
M
A
I
E
C
I
H
V
Y
S
L
I
H
D
D
M
P
C
M
D
N
D
D
L
R
R
G
K
P
T
V
H
K
A
F
D
D
A
S
A
V
L
S
G
--------
D
A
L
Q
A
L
A
F
E
I
L
S
E
E
K
I-
H
T
--
D
--
P
--
H
V
R
L
--
E
-
L
--
I
Q
A
--
L
A
I
A
S
G
K
D
G
M
V
G
--
G
Q
A
I
D
L
A
A
E
T
---
S
T
--
V
P
FD
L
P
T
I
T
R
L
Q
Q
L
K
T
G
A
L
F
G
F
C
L
E
-
A
G
A
I
M
G
-
R
Q
--
N
K
-
D
I
R
D
R
----
L
K
A
Y
A
R
D
I
G
L
A
F
Q
I
A
D
D
L
I
D
A
E
G
D
--------------
G
K
A
T
F
L
S
L
L
G
L
E
K
A
R
-
S
---
Q
A
Q
A
L
V
D
Q
A
I
A
H
---
L
S
V
F
G
---
S
E
A
D
Y
L
R
S
I
A
R
Y
I
V
----
8
PsiBlast_PDB
88.72
40%
-84
- C1 -
4KKM
-
?
A:
[26-317]
--
N
L
K
T
M
M
E
Q
V
A
Q
D
I
D
R
----
L
F
A
--
E
Q
L
P
---
V
--
P
-
E
D
P
------
R
R
R
L
V
E
A
M
R
Y
A
A
I
G
G
G
K
R
L
R
P
L
L
V
V
A
T
--
C
A
L
F
------
N
V
D
--
R
E
A
--
A
L
R
V
G
M
A
I
E
C
I
H
V
Y
S
L
I
H
D
D
M
P
C
M
D
N
D
D
L
R
R
G
K
P
T
V
H
K
A
F
D
D
A
S
A
V
L
S
G
--------
D
A
L
Q
A
L
A
F
E
I
L
S
E
E
K
I-
H
T
--
D
--
P
--
H
V
R
L
--
E
-
L
--
I
Q
A
--
L
A
I
A
S
G
K
D
G
M
V
G
--
G
Q
A
I
D
L
A
A
E
T
---
S
T
--
V
P
F
D
L
P
T
I
T
R
L
Q
Q
L
K
T
G
A
L
F
G
F
C
L
E
-
A
G
A
I
M
G
-
R
Q
--
N
K
-
D
I
R
D
R
----
L
K
A
Y
A
R
D
I
G
L
A
F
Q
I
A
D
D
L
I
D
A
-----------------
G
K
A
T
F
L
S
L
L
G
L
E
K
A
R
-
S
---
Q
A
Q
A
L
V
D
Q
A
I
A
H
---
L
S
V
F
G
---
S
E
A
D
Y
L
R
S
I
A
R
Y
I
V
A
---
26
PsiBlast_CBE
88.70
43%
-75
- C1 -
3M9U
6
?
C:
[8-278]
---
L
I
A
F
E
D
Q
W
V
P
A
L
N
A
---
P
L
K
Q
--
A
I
L
A
---
D
--
S
-
Q
D
A
------
Q
--
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
--
M
Q
S
L
------
G
V
T
FV
P
E
R
--
H
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
--------
D
G
L
L
T
L
A
F
Q
W
L
T
A
T
D
---
L
--
P
--
A
--
T
M
Q
A
--
A
-
L
--
V
Q
A
--
L
A
T
A
A
G
P
S
G
M
V
A
--
G
Q
A
K
D
I
Q
S
E
H
---
V
N
--
L
P
--
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
-
A
G
L
I
L
G
-
Q
A
--
P
E
-
A
Q
W
P
A
----
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
--------------
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
-
Q
---
A
L
I
D
T
I
H
S
G
Q
A
A
---
L
Q
G
-----------------------
3
PsiBlast_PDB
88.48
45%
-68
- C1 -
4LFG
5
?
A:
[6-274]
------------
K
K
I
D
Q
---
T
I
H
A
--
F
Y
C
E
---
K
--
A
V
I
S
E
------
K
--
L
N
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
--
I
E
A
L
------
Q
I
---
P
L
T
E
S
H
F
K
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
--------
D
S
L
F
L
D
A
F
G
M
L
A
E
T
D
---
F
--
P
--
T
--
D
V
T
V
--
D
-
L
--
V
R
S
--
L
S
S
A
S
G
T
F
G
M
V
G
--
G
Q
M
L
D
M
A
A
E
G
---
K
K
--
L
N
--
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
L
A
Y
P
F
W
-
A
A
A
R
V
A
-
Q
L
--
D
E
-
N
L
L
A
T
----
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
E
S
Y
-
Q
---
I
L
D
E
S
L
D
Q
A
E
A
----------------
I
L
R
K
L
S
D
E
I
A
F
---
5
PsiBlast_PDB
88.03
43%
-71
- C1 -
3M9U
6
?
A:
[8-278]
---
L
I
A
F
E
D
Q
W
V
P
A
L
N
A
---
P
L
K
Q
--
A
I
L
A
---
D
--
S
-
Q
D
A
------
Q
--
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
--
M
Q
S
L
------
G
V
T
F
V
P
E
R
--
H
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
--------
D
G
L
L
T
L
A
F
Q
W
L
T
A
T
D
---
L
--
P
--
A
--
T
M
Q
A
--
A
-
L
--
V
Q
A
--
L
A
T
A
A
G
P
S
G
M
V
A
--
G
Q
A
K
D
I
Q
S
E
H
---
V
N
--
L
P
--
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
-
A
G
L
I
L
G
-
Q
A
--
P
E
-
A
Q
W
P
A
----
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
------------
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
-
Q
---
A
L
I
D
T
I
H
S
G
Q
A
A
---
L
Q
G
-----------------------
111
HHSearch
87.42
40%
-79
- C1 -
2J1P
2
GGPPS_SINAL
A:
[13-292]
---
P
I
S
Y
I
I
R
K
A
D
S
V
N
K
---
A
L
D
S
--
A
V
-
P
---
L
--
R
-
E
P
L
------
K
--
I
H
E
A
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
V
L
C
I
A
A
--
C
E
L
V
------
G
G
E
--
E
S
L
--
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
I
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
K
V
Y
G
E
D
V
A
V
L
A
G
--------
D
A
L
L
S
F
A
F
E
H
L
A
S
A
T
--
S
S
--
E
VS
P
--
A
R
V
V
--
R
-
A
--
V
G
E
--
L
A
K
A
I
G
T
E
G
L
V
A
--
G
Q
V
V
D
I
S
---LDL
N
N
--
V
G
--
L
E
H
L
K
F
I
H
L
H
K
T
A
A
L
L
E
A
S
A
V
-
L
G
G
I
I
G
-
G
G
--
S
D
-
E
E
I
E
R
----
L
R
K
F
A
R
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
L
T
Y
P
K
L
M
G
L
E
K
S
R
-
E
---
F
A
E
K
L
N
T
E
A
R
D
Q
---
L
L
G
F
D
S--
D
K
V
A
P
L
L
A
L
A
N
Y
I
A
N
R
Q
-
6
PsiBlast_PDB
87.30
43%
-70
- C1 -
3PDE
5
?
A:
[8-278]
---
L
I
A
F
E
D
Q
W
V
P
A
L
N
A
---
P
L
K
Q
--
A
I
L
A
---
D
--
S
-
Q
D
A
------
Q
--
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
--
M
Q
S
L
------
G
V
T
F
V
P
E
R
--
H
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
--------
D
G
L
L
T
L
A
F
Q
W
L
T
A
T
D
---
L
--
P
--
A
--
T
M
Q
A
--
A
-
L
--
V
Q
A
--
L
A
T
A
A
G
P
S
G
M
V
A
--
G
Q
A
K
D
I
Q
S
E
H
---
V
N
--
L
P
--
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
-
A
G
L
I
L
G
-
Q
A
--
P
E
-
A
Q
W
P
A
----
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
-----------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
-
Q
---
A
L
I
D
T
I
H
S
G
Q
A
A
---
L
Q
G
-----------------------
23
PsiBlast_CBE
87.09
43%
-70
- C1 -
3PDE
4
?
D:
[8-278]
---
L
I
A
F
E
D
Q
W
V
P
A
L
N
A
---
P
L
K
Q
--
A
I
L
A
---
D
--
S
-
Q
D
A
------
Q
--
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
--
M
Q
S
L
------
G
V
T
FV
P
E
R
--
H
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
--------
D
G
L
L
T
L
A
F
Q
W
L
T
A
T
D
---
L
--
P
--
A
--
T
M
Q
A
--
A
-
L
--
V
Q
A
--
L
A
T
A
A
G
P
S
G
M
V
A
--
G
Q
A
K
D
I
Q
S
E
H
---
V
N
--
L
P
--
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
-
A
G
L
I
L
G
-
Q
A
--
P
E
-
A
Q
W
P
A
----
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
P
A
---------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
-
Q
---
A
L
I
D
T
I
H
S
G
Q
A
A
---
L
Q
G
-----------------------
24
PsiBlast_CBE
86.96
43%
-71
- C1 -
3PDE
5
?
C:
[8-278]
---
L
I
A
F
E
D
Q
W
V
P
A
L
N
A
---
P
L
K
Q
--
A
I
L
A
---
D
--
S
-
Q
D
A
------
Q
--
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
--
M
Q
S
L
------
G
V
T
FV
P
E
R
--
H
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
--------
D
G
L
L
T
L
A
F
Q
W
L
T
A
T
D
---
L
--
P
--
A
--
T
M
Q
A
--
A
-
L
--
V
Q
A
--
L
A
T
A
A
G
P
S
G
M
V
A
--
G
Q
A
K
D
I
Q
S
E
H
---
V
N
--
L
P
--
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
-
A
G
L
I
L
G
-
Q
A
--
P
E
-
A
Q
W
P
A
----
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
----------------
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
-
Q
---
A
L
I
D
T
I
H
S
G
Q
A
A
---
L
Q
G
-----------------------
25
PsiBlast_CBE
86.18
43%
-70
- C1 -
3PDE
4
?
B:
[8-278]
---
L
I
A
F
E
D
Q
W
V
P
A
L
N
A
---
P
L
K
Q
--
A
I
L
A
---
D
--
S
-
Q
D
A
------
Q
--
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
--
M
Q
S
L
------
G
V
T
FV
P
E
R
--
H
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
--------
D
G
L
L
T
L
A
F
Q
W
L
T
A
T
D
---
L
--
P
--
A
--
T
M
Q
A
--
A
-
L
--
V
Q
A
--
L
A
T
A
A
G
P
S
G
M
V
A
--
G
Q
A
K
D
I
Q
S
E
H
---
V
N
--
L
P
--
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
-
A
G
L
I
L
G
-
Q
A
--
P
E
-
A
Q
W
P
A
----
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
-----------
D
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
-
Q
---
A
L
I
D
T
I
H
S
G
Q
A
A
---
L
Q
G
-----------------------
27
PsiBlast_CBE
86.04
43%
-71
- C1 -
3M9U
3
?
B:
[8-278]
---
L
I
A
F
E
D
Q
W
V
P
A
L
N
A
---
P
L
K
Q
--
A
I
L
A
---
D
--
S
-
Q
D
A
------
Q
--
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
--
M
Q
S
L
------
G
V
T
FV
P
E
R
--
H
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
--------
D
G
L
L
T
L
A
F
Q
W
L
T
A
T
D
---
L
--
P
--
A
--
T
M
Q
A
--
A
-
L
--
V
Q
A
--
L
A
T
A
A
G
P
S
G
M
V
A
--
G
Q
A
K
D
I
Q
S
E
H
---
V
N
--
L
P
--
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
-
A
G
L
I
L
G
-
Q
A
--
P
E
-
A
Q
W
P
A
----
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
-------------
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
G
A
N
-
Q
---
A
L
I
D
T
I
H
S
G
Q
A
A
---
L
Q
G
-----------------------
45
PsiBlast_CBE
84.65
42%
-86
- C1 -
3ZMB
2
?
B:
[31-292]
-----------------------------------------------
R
--
L
Y
E
A
M
R
Y
S
V
M
N
G
G
K
R
V
R
P
L
L
A
Y
A
A
--
C
E
A
L
------
G
G
A
--
P
Q
R
--
A
D
A
A
A
C
A
V
E
L
I
H
A
Y
S
L
V
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
Q
P
T
T
H
R
A
F
D
E
A
T
A
I
L
A
A
--------
D
G
L
Q
A
L
A
F
E
V
L
A
D
T
R
--
R
N
--
P
--
Q
--
E
H
A
V
--
C
-
L
E
M
L
T
R
--
L
A
R
A
A
G
S
A
G
M
V
G
--
G
Q
A
I
D
L
G
S
V
G
---
V
A
--
L
D
--
Q
A
A
L
E
V
M
H
R
H
K
T
G
A
L
I
E
A
S
V
R
L
G
A
L
A
S
G
-
R
A
--
E
P
-
A
S
L
A
A
----
L
E
R
Y
A
E
A
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
E
------------------
P
T
Y
P
A
L
L
G
L
E
A
A
K
-
G
---
Y
A
L
E
L
R
D
L
A
L
A
A
---
L
D
G
F
P
---
P
S
A
D
P
L
R
Q
L
A
R
Y
I
V
----
46
PsiBlast_CBE
84.42
42%
-84
- C1 -
3ZMB
3
?
A:
[31-295]
-----------------------------------------------
R
--
L
Y
E
A
M
R
Y
S
V
M
N
G
G
K
R
V
R
P
L
L
A
Y
A
A
--
C
E
A
L
------
G
G
A
--
P
Q
R
--
A
D
A
A
A
C
A
V
E
L
I
H
A
Y
S
L
V
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
Q
P
T
T
H
R
A
F
D
E
A
T
A
I
L
A
A
--------
D
G
L
Q
A
L
A
F
E
V
L
A
D
T
R
--
R
N
--
P
--
Q
--
E
H
A
V
--
C
-
L
E
M
L
T
R
--
L
A
R
A
A
G
S
A