@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1513: (2016-03-25 )
MENRIYLDHAATSPIHPEVIQTMLGAITNTYGNPSSIHYAGREARKALDEARHTIAKSIHATEKEIIFTSGGTEGDNLALIGTALAHKENGTHIITSQIEHHAVLKTCEYLETQGFEVTYLPVDEHGIVSVESVQAALRPETILVSIMYGNNEIGSIQPIAEIGALLRDQQAIFHTDAVQAYGLLNINVMELGVDLLTTSSHKINGPRGVGFLYVKNGTRLAYQMHGGEQERKRRAGTENLAGICGFSAASSIMTNERELKNEEYISFKKRMAEIWRSAELDFEVNGLEADTLPHVFSVRFPGVSIEQLLMNLDMEGIAVSSGSACTAGTVDPSHVLVALFGENHPAIQETVRISFGLGNHLEEVEMAATKISEVVTRLMKI
Atome Classification :
(23 SA)
.........10........20.......--.30.....-...40........50........60........70........80......-------..90.-.--------.---......100.......110..-.-.....120...-....130.......140.........150.......160.....--..----------170--------.........180.......190.......200.......210...--.-----...220-----..--..--.-...---.230.......240.......250..-----.....260-.......270.......280....-------..----.290-.......300...--....310.......320.......330.-.......340.......350.......360.......370.......380---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEN
R
I
Y
L
DHAATSPI
H
P
E
V
I
Q
T
M
L
G
A
I
T
--NTYGNPS
S
-
I
HYA
G
R
E
A
R
K
A
L
D
E
A
R
H
T
I
A
K
S
IHATE
K
E
I
I
F
TSGGTEGD
N
L
A
L
I
G
T
ALAH-------KEN-G-
T
--------
H
---
I
I
T
S
QI
E
H
H
A
V
L
K
T
C
E
Y
L
-ET-Q-G
F
E
V
T
Y
L
PVDE-HG
I
V
S
V
E
S
V
Q
A
ALRP--
E
T
I
L
V
S
I
M
YGNNEIGSI
Q
P
I
A
E
I
G
A
L
L
--
R
D
----------
Q
----------
Q
A
I
F
H
T
D
A
V
Q
A
YG
L
L
N
I
N
V
MELG
V
D
L
LTTSSHKINGPR
G
V
G
F
L
Y
V--K-----NG
T
R
-------
L
A
--
Y
Q
--M-HG
G
---
E
Q
E
R
K
R
RAGTE
N
L
A
G
IC
G
F
S
A
A
S
S
I
M-----T
N
E
R
ELK
N
-
E
E
Y
I
S
F
K
K
R
M
A
E
I
W
R
SAEL
D
F
E
VN-------GL----EADT-LP
H
V
F
S
V
RFPGV
S
--
I
E
Q
L
L
M
NLDME
G
I
A
VSSGSACTAGTV-D-PS
H
V
L
V
A
L
FGENHP
A
I
Q
E
T
V
R
I
S
FGLG
N
H
L
E
E
V
E
M
A
A
T
K
I
S
E
V
V
T
R
L
MKI---
21
PsiBlast_CBE
98.90
42%
-83
- C2 -
3LVJ
2
ISCS_ECO57
B:
[20-399]
M
K
L
P
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
MD
G
T
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
A
A
N
F
Y
-------
Q
K
K
-
G
-
K
--------
H
---
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
-
E
-
G
F
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
D
--
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
--
R
A
----------
R
----------
G
I
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
RR
K
-----
P
R
V
R
-------
I
E
--
A
Q
--
M
-
H
G
G
---
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
-----
K
E
E
M
A
T
E
M
-
E
R
L
R
G
L
R
N
R
L
W
N
G
I
K
D
I
E
-
E
V
Y
L
N
-------
G
D
----
L
E
H
G
-
A
P
N
I
L
N
V
S
F
N
Y
V
E
--
G
E
S
L
I
M
A
L
--
K
D
L
A
V
S
S
G
S
A
C
----
L
-
E
-
P
S
Y
V
L
R
A
L
-
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
------
2
PsiBlast_PDB
98.03
42%
-81
- C2 -
3LVK
1
ISCS_ECO57
A:
[20-399]
M
K
L
P
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
MD
G
T
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
A
A
N
F
Y
-------
Q
K
K
-
G
-
K
--------
H
---
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
-
E
-
G
F
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
D
--
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
--
R
A
----------
R
----------
G
I
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
R
K
-----
P
R
V
R
-------
I
E
--
A
Q
--
M
-
H
G
G
---
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
-----
K
E
E
M
A
T
E
M
-
E
R
L
R
G
L
R
N
R
L
W
N
G
I
K
D
I
E
-
E
V
Y
L
N
-------
G
D
----
L
E
H
G
-
A
P
N
I
L
N
V
S
F
N
Y
V
E
--
G
E
S
L
I
M
A
L
--
K
D
L
A
V
S
S
G
S
A
C
----
L
-
E
-
P
S
Y
V
L
R
A
L
-
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
------
1
PsiBlast_PDB
97.56
42%
-84
- C2 -
3LVJ
2
ISCS_ECO57
A:
[20-399]
M
K
L
P
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
MD
G
T
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
A
A
N
F
Y
-------
Q
K
K
-
G
-
K
--------
H
---
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
-
E
-
G
F
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
D
--
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
--
R
A
----------
R
----------
G
I
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
R
K
-----
P
R
V
R
-------
I
E
--
A
Q
--
M
-
H
G
G
---
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
-----
K
E
E
M
A
T
E
M
-
E
R
L
R
G
L
R
N
R
L
W
N
G
I
K
D
I
E
-
E
V
Y
L
N
-------
G
D
----
L
E
H
G
-
A
P
N
I
L
N
V
S
F
N
Y
V
E
--
G
E
S
L
I
M
A
L
--
K
D
L
A
V
S
S
G
------
S
L
-
E
-
P
S
Y
V
L
R
A
L
-
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
------
63
Fugue
93.01
37%
-84
- C2 -
4ISY
3
ISCSL_MYCTU
A:
[12-398]
---
S
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
-
A
A
V
Q
--
R
T
I
G
N
A
S
S
-
L
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
G
I
Y
W
A
R
-------
R
D
A
-
E
-
P
--------
H
RR
R
I
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
-
V
E
-
H
E
G
A
H
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
V
A
--
M
E
----------
F
----------
G
V
P
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
--
R
-----
R
D
V
T
-------
C
V
--
P
L
--
M
-
H
G
G
---
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
-----
V
D
G
L
E
E
N
S
-
A
R
L
R
L
L
R
D
R
L
V
E
G
V
L
A
E
I
D
D
V
C
L
N
-------
G
A
----
D
D
P
M
R
L
A
G
N
A
H
F
T
F
R
G
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
-
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
ALA
5
PsiBlast_PDB
92.83
37%
-81
- C2 -
4HVK
12
ISCS2_ARCFU
A:
[3-373]
-----
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
-
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
A
M
R
N
-------
A
R
K
-
G
-
K
--------
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
-
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
D
--
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
--
A
G
----------
K
----------
A
A
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
-----
K
E
A
K
-------
L
Q
--
P
V
--
I
-
L
G
G
---
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
-----
A
M
E
W
R
E
E
A
-
E
R
L
R
R
L
R
D
R
I
I
D
N
V
L
K
I
E
E
S
Y
-
L
N
-------
G
H
----
P
E
K
R
-
L
P
N
N
V
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
---------
Q
-
P
S
H
V
L
M
A
C
-
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
------
4
PsiBlast_PDB
91.93
37%
-75
- C2 -
4EB7
7
ISCS2_ARCFU
A:
[3-373]
-----
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
-
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
A
M
R
N
-------
A
R
K
-
G
-
K
--------
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
-
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
D
--
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
--
A
G
----------
K
----------
A
A
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
-----
K
E
A
K
-------
L
Q
--
P
V
--
I
-
L
G
G
---
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
-----
A
M
E
W
R
E
E
A
-
E
R
L
R
R
L
R
D
R
I
I
D
N
V
L
K
I
E
E
S
Y
-
L
N
-------
G
H
----
P
E
K
R
-
L
P
N
N
V
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
-
T
L
-
Q
-
P
S
H
V
L
M
A
C
-
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
------
23
PsiBlast_CBE
91.84
37%
-80
- C2 -
4EB5
5
ISCS2_ARCFU
B:
[3-373]
-----
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
-
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
A
M
R
N
-------
A
R
K
-
G
-
K
--------
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
-
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
D
--
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
--
A
G
----------
K
----------
A
A
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
-----
K
E
A
K
-------
L
Q
--
P
V
--
I
-
L
G
G
---
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
-----
A
M
E
W
R
E
E
A
-
E
R
L
R
R
L
R
D
R
I
I
D
N
V
L
K
I
E
E
S
Y
-
L
N
-------
G
H
----
P
E
K
R
-
L
P
N
N
V
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
T
L
-
Q
-
P
S
H
V
L
M
A
C
-
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
------
3
PsiBlast_PDB
91.82
37%
-77
- C2 -
4EB5
6
ISCS2_ARCFU
A:
[3-373]
-----
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
-
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
A
M
R
N
-------
A
R
K
-
G
-
K
--------
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
-
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
D
--
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
--
A
G
----------
K
----------
A
A
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
-----
K
E
A
K
-------
L
Q
--
P
V
--
I
-
L
G
G
---
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
-----
A
M
E
W
R
E
E
A
-
E
R
L
R
R
L
R
D
R
I
I
D
N
V
L
K
I
E
E
S
Y
-
L
N
-------
G
H
----
P
E
K
R
-
L
P
N
N
V
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
T
L
-
Q
-
P
S
H
V
L
M
A
C
-
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
------
70
HHSearch
91.08
36%
-84
- C2 -
1EG5
3
?
A:
[2-376]
---
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
-
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
E
T
F
--------
E
K
R
K
-
R
--------
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
-
K
-
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
E
--
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
--
K
K
----------
K
NK--------
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
--
R
-----
K
G
V
P
-------
I
R
--
P
L
--
I
-
H
G
G
---
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
-----
V
E
E
L
S
E
A
A
-
K
H
M
E
K
L
R
S
K
L
V
S
G
L
M
N
L
--
G
A
H
I
I
-------
T
P
----
L
E
I
S
-
L
P
N
T
L
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
G
-
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
11
PsiBlast_PDB
90.71
34%
-76
- C2 -
3A9Z
5
SCLY_RAT
A:
[19-428]
---
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
-
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
-------
H
E
Q
-
Q
-
T
L
QT
R
P
---
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
-
Q
-
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
P
--
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
--
K
A
L
N
Q
I
R
A
A
S
GL
P
----------
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
--
R
-----
G
V
G
K
-------
L
T
P
L
Y
P
--
M
L
F
G
G
---
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
-
E
R
L
E
A
E
F
G
K
R
I
H
L
N
S
R
F
P
-------
G
V
----
E
--
R
-
L
P
N
T
C
N
F
S
I
Q
G
S
Q
--
L
R
G
Y
M
V
L
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
-
D
R
P
S
P
V
L
L
S
C
-
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------
61
Fugue
90.62
35%
-85
* C2 *
1ECX
2
?
A:
[1-376]
--
M
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
-
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
E
T
F
-------
E
K
R
-
K
-
R
--------
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
-
K
-
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
E
--
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
--
K
K
K
N--------
K
----------
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
--
R
-----
K
G
V
P
-------
I
R
--
P
L
--
I
-
H
G
G
---
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
-----
V
E
E
L
S
E
A
A
-
K
H
M
E
K
L
R
S
K
L
V
S
G
L
M
--
N
L
G
A
H
I
I
-------
T
P
----
L
E
I
S
-
L
P
N
T
L
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
-
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
75
HHSearch
90.38
34%
-79
- C2 -
3A9Z
5
SCLY_RAT
A:
[18-430]
--
R
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
-
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
H
E
Q
Q
T
L
Q--
T
-
R
-
P
--------
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
-
V
E
D
Q
-
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
P
--
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
--
K
A
----------
L
N
Q
I
R
A
A
S
GL
P
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
--
R
-----
G
V
G
K
-------
L
T
--
P
L
--
Y
-
P
M
L
FGG
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
-----
S
E
N
C
E
T
Y
E
-
A
H
M
R
D
I
R
D
Y
L
E
E
R
L
E
A
-
E
F
G
K
R
I
H
-------
L
N
SRFP
G
V
E
R
-
L
P
N
T
C
N
F
S
I
Q
G
S
Q
LR
G
Y
M
V
L
A
--
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
D
R
-
P
S
P
V
L
L
S
C
G
-
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
----
22
PsiBlast_CBE
90.20
37%
-81
- C2 -
4EB7
4
ISCS2_ARCFU
B:
[3-373]
-----
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
-
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
A
M
R
N
-------
A
R
K
-
G
-
K
--------
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
-
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
D
--
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
--
A
G
----------
K
----------
A
A
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
-----
K
E
A
K
-------
L
Q
--
P
V
--
I
-
L
G
G
---
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
-----
A
M
E
W
R
E
E
A
-
E
R
L
R
R
L
R
D
R
I
I
D
N
V
L
K
I
E
E
S
Y
-
L
N
-------
G
H
----
P
E
K
R
-
L
P
N
N
V
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
T
L
-
Q
-
P
S
H
V
L
M
A
C
-
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
------
30
PsiBlast_CBE
90.19
34%
-74
- C2 -
3A9Y
4
SCLY_RAT
B:
[19-428]
---
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
-
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
-------
H
E
Q
-
Q
--T
R
P
-----
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
-
Q
-
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
P
--
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
--
K
A
L
N
Q
I
R
A
A
S
G
L
P
----------
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
--
R
-----
G
V
G
K
-------
L
T
P
L
Y
P
--
M
L
F
G
G
---
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
-
E
R
L
E
A
E
F
G
K
R
I
H
L
N
S
R
F
P
-------
G
V
----
E
--
R
-
L
P
N
T
C
N
F
S
I
Q
G
S
Q
--
L
R
G
Y
M
V
L
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
-
D
R
P
S
P
V
L
L
S
C
-
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------
29
PsiBlast_CBE
89.86
34%
-73
- C2 -
3A9Z
3
SCLY_RAT
B:
[19-428]
---
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
-
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
-------
H
E
Q
----T
R
P
-----
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
-
Q
-
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
P
--
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
--
K
A
L
N
Q
I
R
A
A
S
G
L
P
----------
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
--
R
-----
G
V
G
K
-------
L
T
P
L
Y
P
--
M
L
F
G
G
---
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
-
E
R
L
E
A
E
F
G
K
R
I
H
L
N
S
R
F
P
-------
G
V
----
E
--
R
-
L
P
N
T
C
N
F
S
I
Q
G
S
Q
--
L
R
G
Y
M
V
L
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
-
D
R
P
S
P
V
L
L
S
C
-
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------
31
PsiBlast_CBE
89.70
34%
-73
- C2 -
3A9X
5
SCLY_RAT
B:
[19-428]
---
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
-
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
-------
H
E
Q
-
Q
-
T
L
QT
R
P
---
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
-
Q
-
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
P
--
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
--
K
A
L
N
Q
I
R
A
A
S
G
L
P
----------
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
--
R
-----
G
V
G
K
-------
L
T
P
L
Y
P
--
M
L
F
G
G
---
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
-
E
R
L
E
A
E
F
G
K
R
I
H
L
N
S
R
F
P
-------
G
V
----
E
--
R
-
L
P
N
T
C
N
F
S
I
Q
G
S
Q
--
L
R
G
Y
M
V
L
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
-
D
R
P
S
P
V
L
L
S
C
-
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------
24
PsiBlast_CBE
89.23
38%
-79
- C2 -
4ISY
1
ISCSL_MYCTU
D:
[14-370]
-----
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
-
A
A
V
Q
--
R
T
I
G
N
A
S
S
-
L
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
G
I
Y
W
A
R
-------
R
D
A
-
E
-
P
--------
H
RRR
I
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
H
-
E
-
G
A
H
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
HD
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
V
A
--
M
E
----------
F
----------
G
V
P
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
--
R
-----
R
D
V
T
-------
C
V
--
P
L
--
M
-
H
G
G
---
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
-----
V
D
G
L
E
E
N
S
-
A
R
L
R
L
L
R
D
R
L
V
E
G
V
L
A
E
I
D
D
V
C
L
N
-------
G
A
----
D
D
P
M
R
L
A
G
N
A
H
F
T
F
R
G
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
-
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
----------------------------
9
PsiBlast_PDB
89.10
35%
-86
- C2 -
1EG5
3
?
A:
[2-376]
---
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
-
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
E
T
F
-------
E
K
R
-
K
-
R
--------
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
-
K
-
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
E
--
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
K
K
K
N
----------
K
----------
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
--
R
-----
K
G
V
P
-------
I
R
--
P
L
--
I
-
H
G
G
---
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
-----
V
E
E
---------
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
M
N
L
GAHIIT
P
L
----
E
I
-
S
-
L
P
N
T
L
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
-
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
7
PsiBlast_PDB
89.06
36%
-87
- C2 -
1ECX
2
?
A:
[2-376]
---
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
-
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
E
T
F
-------
E
K
R
-
K
-
R
--------
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
-
K
-
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
E
--
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
K
K
K
N
----------
K
----------
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
--
R
-----
K
G
V
P
-------
I
R
--
P
L
--
I
-
H
G
G
---
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
-----
V
E
E
---------
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
M
N
L
GAHIIT
P
L
----
E
I
-
S
-
L
P
N
T
L
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
-
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
27
PsiBlast_CBE
88.98
36%
-87
- C2 -
1ECX
2
?
B:
[2-376]
---
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
-
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
E
T
F
-------
E
K
R
-
K
-
R
--------
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
-
K
-
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
E
--
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
KK
K
N
----------
K
----------
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
--
R
-----
K
G
V
P
-------
I
R
--
P
L
--
I
-
H
G
G
---
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
-----
V
E
E
---------
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
M
N
LGAHIIT
P
L
----
E
I
-
S
-
L
P
N
T
L
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
-------------
R
H
V
L
D
A
M
-
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
10
PsiBlast_PDB
88.47
34%
-78
- C2 -
3A9X
3
SCLY_RAT
A:
[19-428]
---
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
-
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
-------
H
E
Q
-
Q
-
T
L
Q
GEG
T
R
P
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
-
Q
-
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
P
--
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
--
K
A
L
N
Q
I
R
A
A
S
G
L
P
----------
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
--
R
-----
G
V
G
K
-------
L
T
P
L
Y
P
--
M
L
F
G
G
---
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
-
E
R
L
E
A
E
F
G
K
R
I
H
L
N
S
R
F
P
-------
G
V
----
E
--
R
-
L
P
N
T
C
N
F
S
I
Q
G
S
Q
--
L
R
G
Y
M
V
L
A
Q
C
Q
T
L
L
A
S
V
G
A
---------------------
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------
28
PsiBlast_CBE
87.62
37%
-75
- C2 -
3VAX
2
?
B:
[23-379]
-----
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
--
A
E
F
G
N
A
G
S
-
R
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
G
L
A
P
Y
G
-------
E
R
T
-
G
-
R
R-------
H
---
I
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
-
A
G
-
R
-
G
F
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
P
--
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
--
R
A
----------
T
----------
P
T
Y
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
-
L
T
T
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
--
R
RREEM
D
D
E
R
-------
V
P
--
L
E
PI
M
-
F
G
G
---
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
-----
E
A
E
H
A
Q
W
Q
-
V
A
A
Q
D
L
R
S
R
L
--
L
A
G
L
A
S
T
S
F
Q
V
N
-------
G
D
----
Q
D
H
V
-
V
P
H
I
L
N
L
S
F
E
D
V
D
--
A
E
A
F
L
V
T
L
K
-
D
L
V
A
V
A
T
G
S
A
S
T
S
A
S
F
-
T
-
P
S
H
V
L
R
A
M
-
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------
71
HHSearch
85.77
37%
-73
- C2 -
3VAX
1
?
A:
[22-379]
----
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
--
A
E
F
G
N
A
G
S
-
R
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
G
L
A
P
Y
G
-------
E
R
T
-
G
R
R
--------
H
---
I
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
-
A
G
-
R
-
G
F
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
P
--
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
--
R
A
----------
T
----------
P
T
Y
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
T
T
-
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
--
R
-----
R
R
E
E
MDDERVP
L
E
--
P
I
--
M
-
F
G
G
---
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
-----
E
A
E
H
A
Q
W
Q
-
V
A
A
Q
D
L
R
S
R
L
L
A
G
L
A
S
T
--
S
F
Q
V
N
-------
G
D
----
Q
D
H
V
-
V
P
H
I
L
N
L
S
F
E
D
V
D
--
A
E
A
F
L
V
T
L
K
-
D
L
V
A
V
A
T
G
S
A
S
T
S
A
S
F
-
T
-
P
S
H
V
L
R
A
M
G
-
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------