@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1694: (2016-03-27 )
LHILLTGATGFIGDHLVHELEKSDHELYILTRQKLKNRANVHYIEWLNEDKLPNLEDLPVDVCINLAGAGLMDEKWTYDRKKVIVNSRIEATSALLSIVKKMKSKPKLWINASAIGAYTSSKSTIYLDTEENTYADNFLGKTVYEWEKTASAASDLGIRVVYARFGLVLGTNGGSFPVFEKLFQTYTGGRFGNGRQWYSWIHVDDVVAAILFIFDHEQINGVVNFTAPHPVQEKKFAERLGKKMHKPYKTPVPKKIIKFILGERAMTILDSQRAYPEKLMSNHFEFRFETLQEALDDLLD
Atome Classification :
(20 SA)
--.........10........20..-.--.------.--...30.......----------.40--.---.-.-.-----..--.---..50......---.--.60....-....70.-------.--......80........90........100.-------......110.......120-..---------------.....130-----.--.-..-...140-----........-.150.------..-....160..----.....170.--.--------.-----------.-------..----.---180---..---.-----.-.--.--.-.190--.------........200.......210.....----.----.220......--.-230.......240.......--250--......-----..260----.--.--....--..270.......280........290.......300--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--
L
H
I
L
L
TGAT
G
F
I
G
D
H
L
V
H
E
L
E
KS-D--H------
E
--
L
Y
I
L
T
R
Q
K
LKNR----------AN---
V
---
H
-
Y
-
I
-----
E
W--L---NEDKLPN
L
E
D---L--
P
V
D
V
C
I
N
-LAGAGLM-------D--EKWTYDR
K
K
V
I
VNSR
I
E
A
T
S
A
L
L
S
I
V
K
K
MK-------SKP
K
L
W
I
N
A
S
A
I
G
A
YTSS
K
-
S
T
---------------
I
Y
L
DTEEN-----T--Y-
A
D
-
N
F
LG-------
K
T
V
Y
E
W
E
K
-
T
ASA
A
------
S
D-L
G
I
R
V
V
Y
A
R----
F
G
L
V
L
GTNG--G--------S-----------
F
-------
P
V
----
F
---
E
K
----
L
F
---
Q
-----
T
-Y--T--G-GR----F------GNG
R
Q
W
Y
S
W
I
H
V
D
D
V
V
A
A
I
L
F
I
FD
H
E
----Q----IN
G
V
V
NFTAP--H-P
V
Q
E
K
K
F
A
E
R
L
G
K
K
MHKPYK--T-P--V
P
K
K
I
I
-----
K
F
I
L
-----
G
--
E
--
R
A
M
T
--
I
L
DSQRA
Y
P
E
K
L
M
-
S
N
H
F
E
F
R
F
E
T
L
Q
E
A
L
D
D
LLD----
2
PsiBlast_PDB
98.29
27%
-98
- C1 -
4B4O
2
D39U1_HUMAN
A:
[2-293]
---
R
V
L
V
G
G
G
T
G
F
I
G
T
A
L
T
Q
L
L
N
A
R
-
G
--
H
------
E
--
V
T
L
V
S
R
K
P
G
P
G
R
-----------------------
I
-----
T
W
D
E
L
---
A
A
S
G
L
P
S
----------
C
D
A
A
V
N
-
L
A
G
E
N
I
L
-------
N
PL
R
R
W
N
E
T
F
Q
K
E
V
L
G
S
R
L
E
T
T
Q
L
L
A
K
A
I
T
K
A
P
-------
Q
P
P
K
A
W
V
L
V
T
G
V
A
Y
Y
Q
P
S
L
-
T
A
---------------
E
Y
--
D
E
D
S
-----
P
--
G
-
G
D
F
D
F
F
S
-------
N
L
V
T
K
W
E
A
-
A
A
R
L
P
------
G
D
--
S
T
R
Q
V
V
V
R
----
S
G
V
V
L
G
R
G
G
--
G
--------
A
-----------
M
-------
G
H
----
M
---
L
L
----
P
F
---
R
-----
L
-
G
--
L
--
G
-
G
P
----
I
------
G
S
G
H
Q
F
F
P
W
I
H
I
G
D
L
A
G
I
L
T
H
A
L
E
A
N
----
H
----
V
H
G
V
L
N
G
V
A
P
--
S
-
S
A
T
N
A
E
F
A
Q
T
F
G
A
A
L
G
R
R
A
F
--
I
-
P
--
L
P
S
A
V
V
-----
Q
A
V
F
-----
G
R
-
Q
--
R
A
I
M
--
L
L
E
G
Q
K
V
I
P
R
R
T
L
-
A
T
G
Y
Q
Y
S
F
P
E
L
G
A
A
L
K
E
I
A
E
----
31
HHSearch
79.58
21%
-96
- C1 -
3KO8
2
?
A:
[1-303]
--
M
R
I
V
V
T
G
G
A
G
F
I
G
S
H
L
V
D
K
L
V
E
L
-
G
--
Y
------
E
--
V
V
V
V
D
N
L
S
S
G
R
R
EFVN------
P
S
---
A
---
E
-
L
-
H
V----
R
D
--
L
---
K
D
Y
--
S
W
G
A
G
---
I
--
K
G
D
V
V
F
H
-
F
A
A
N
P
E
V
-----------
R
L
S
T
T
E
P
I
V
H
F
N
E
N
V
V
A
T
F
N
V
L
E
W
A
R
Q
T
---------
G
V
R
T
V
V
F
A
S
S
S
T
V
Y
G
D
A
D
-
V
----------------
I
P
T
P
E
E
E
------
P
--
Y
K
P
I
-
S
V
Y
G
-------
A
A
K
A
A
G
E
V
-
M
C
A
T
Y
A
-----
R
L
-
F
G
V
R
C
L
A
V
R
----
Y
A
N
V
V
G
P
R
L
RH
G
--------
V
-----------
I
-------
Y
D
----
F
---
I
M
----
K
L
---
R
-----
R
N
P
--
N
V
-
L
-
E
V
----
L
----------
Q
R
K
S
Y
L
Y
V
R
D
A
V
E
A
T
L
A
A
W
K
K
F
E
E
M
D
A
----
P
F
L
A
L
N
V
G
N
V
--
D
-
A
V
R
V
L
D
I
A
Q
I
V
A
E
V
L
G
L
R
P
E
I
-
R
-
L
--
V
----------------------------
G
--
D
V
K
Y
M
T
L
A
V
T
K
L
M
K
L
T
G
W
R
P
T
M
-
T
S
A
E
A
V
K
K
T
A
-----
25
HHSearch
76.14
16%
-100
- C1 -
2PK3
2
RMD_ANETH
A:
[13-315]
--
M
R
A
L
I
T
G
V
A
G
F
V
G
K
Y
L
A
N
H
L
T
E
Q
-
N
--
V
------
E
--
V
F
G
T
S
R
N
N
E
A
K
L
P
NV-------
E
M
---
I
---
S
-
L
-
D
I----
M
D
--
S
---
Q
R
-
V
K
K
V
I
S
D
---
I
--
K
P
D
Y
I
F
H
-
L
A
A
K
S
S
V
-----------
K
D
S
W
L
N
K
K
G
T
F
S
T
N
V
F
G
T
L
H
V
L
D
A
V
R
D
S
--------
N
L
D
C
R
I
L
T
I
G
S
S
E
E
Y
G
M
I
L
P
E
E
---------------
S
P
V
S
E
E
N
------
Q
--
L
R
P
M
-
S
P
Y
G
-------
V
S
K
A
S
V
G
M
-
L
A
R
Q
Y
V
-----
K
A
-
Y
G
M
D
I
I
H
T
R
----
T
F
N
H
I
G
P
G
Q
--
S
--------
L
GF
V
--------
T
-------
Q
D
----
F
---
A
K
----
Q
I
---
V
D
I
E
M
E
K
-
Q
--
E
P-
I
-
I
K
----
V
------
G
N
L
E
A
V
R
D
F
T
D
V
R
D
I
V
Q
A
Y
W
L
L
S
Q
Y
G
----
K
----
T
G
D
V
Y
N
V
C
S
G
--
I
-
G
T
R
I
Q
D
V
L
D
L
L
L
A
M
A
N
V
K
I
D
--
T
-
E
--
L
N
P
L
---------
Q
L
-----
R
--
P
-----
S
--
E
V
P
T
L
I
G
S
N
K
R
L
K
D
S
T
G
W
K
P
R
I
-
P
L
E
K
S
L
F
E
I
L
-----
1
PsiBlast_PDB
75.94
31%
-62
- C1 -
3OH8
-
?
A:
[148-463]
--
L
T
V
A
I
T
G
S
R
G
L
V
G
R
A
L
T
A
Q
L
Q
T
G
-
G
--
H
------
E
--
V
I
Q
L
V
R
K
E
P
K
P
G
----------
K
R
---
F
--------------
W
--------
D
P
L
N
P
A
S
D
---
L
LD
G
A
D
V
L
V
H
-
L
A
G
E
---------------
F
N
D
S
H
K
E
A
I
R
E
S
R
V
L
P
T
K
F
L
A
E
L
V
A
E
-
S
-------
T
Q
C
T
T
M
I
S
A
S
A
V
G
F
Y
G
H
D
R
-
G
D
---------------
E
I
L
-
T
E
E
S
-----
E
--
S
-
G
D
-
D
F
L
A
-------
E
V
C
R
D
W
E
H
-
A
T
A
P
A
------
S
D
-
A
G
K
R
V
A
F
I
R
----
T
G
V
A
L
S
G
R
G
--
G
--------
M
-----------
L
-------
P
L
----
L
---
K
T
----
L
F
---
S
-------------
G
-
G
K
----
F
------
G
D
G
T
S
W
F
S
W
I
A
I
D
D
L
T
D
I
Y
Y
R
A
I
V
D
A
----
Q
----
I
S
G
P
I
N
A
V
A
P
--
N
-
P
V
S
N
A
D
M
T
K
I
L
A
T
----------------------------------------
Q
G
A
E
EL
A
L
A
S
Q
R
T
A
P
A
A
L
E
-
N
L
S
H
T
F
R
Y
T
D
I
G
A
A
I
---------
47
Fugue
74.64
19%
-96
- C1 -
3GPI
3
?
A:
[2-279]
SL
S
K
I
L
I
A
G
C
-
G
D
L
G
L
E
L
A
R
R
L
T
A
Q
-
G
--
H
------
E
--
V
T
G
L
R
R
S
A
Q
P
M
P
----------
A
G
---
V
---
Q
-
T
-
L
-----
I
A
D
V
T
---
R
P
D
T
L
A
S
I
V
H
---
L
--
R
P
E
I
L
V
Y
-
C
V
A
A
S
E
Y
-------
S
--
L
S
Y
------------
V
E
G
L
R
N
T
L
S
A
L
E
G
---------
A
P
L
Q
H
V
F
F
V
S
S
T
G
V
Y
G
Q
E
V
-
E
E
----------------
W
L
D
E
D
T
P
-----
P
--
I
-
A
K
-
D
F
S
G
-------
K
R
M
L
E
A
E
A
-
L
L
A
A
------------
Y
S
S
T
I
L
R
----
F
S
G
I
Y
G
P
G
R
--
L
--------
R
-----------
M
-------
I
R
----
Q
---
A
Q
--------------------
T
--
P
-
E
Q
----
W
------
P
A
R
N
A
W
T
N
R
I
H
R
D
D
G
A
A
F
I
A
Y
L
I
Q
Q
R
SHA-
V
----
P
E
R
L
Y
I
V
T
D
N
--
Q
-
P
L
P
V
H
D
L
L
R
W
L
A
D
R
Q
G
I
A
Y
P
--
A
-
G
--
A
T
P
P
V
----------------------------
Q
G
N
K
K
L
S
N
A
R
L
L
-
A
S
G
Y
Q
L
I
Y
P
D
Y
V
S
G
Y
G
A
L
L
A
A
M
R
E
34
HHSearch
71.40
17%
-90
- C1 -
1R6D
2
?
A:
[1-308]
--
M
R
L
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
-
A
--
Y
PDVPAD
E
--
V
I
V
L
D
S
L
T
Y
A
G
N
RANLAPVDAD
P
R
L
R
F
V
---
H
-
G
-
D
I----
R
D
--
A
----
G
L
L
A
R
E
L
R
-------
G
V
D
A
I
V
H
-
F
A
A
E
S
H
V
-----------
D
R
S
I
A
G
A
S
V
F
T
E
T
N
V
Q
G
T
Q
T
L
L
Q
C
A
V
D
A
---------
G
V
G
R
V
V
H
V
S
T
N
Q
V
Y
G
S
I
D
-
S
----------------
G
S
W
T
E
S
S
------
P
--
L
E
P
N
-
S
P
Y
A
-------
A
S
K
A
G
S
D
L
-
V
A
R
A
Y
H
-----
R
T
-
Y
G
L
D
V
R
I
T
R
----
C
C
N
N
Y
G
P
Y
Q
--
H
PEK-----
L
-----------
I
-------
P
L
----
F
---
V
T
----
N
L
---
L
-----
D
-
G
--
G
T-
L
-
P
L
----
Y
------
G
D
G
A
N
V
R
E
W
V
H
T
D
D
H
C
R
G
I
A
L
V
L
A
G
G
----
R
----
A
G
E
I
Y
H
I
G
G
G
--
L
-
E
L
T
N
R
E
L
T
G
I
L
L
D
S
L
G
A
D
W
S
----
S
--
V
R
K
V
-
A
--------------
D
-----
R
-
K
G
--
H
D
L
R
Y
S
L
D
G
G
K
I
E
R
E
L
G
Y
R
P
Q
V
-
S
F
A
D
G
L
A
R
T
V
-----
26
HHSearch
70.84
17%
-82
* C1 *
1ORR
2
RFBE_SALTI
A:
[2-334]
--
A
K
L
L
I
T
G
G
C
G
F
L
G
S
N
L
A
S
F
A
L
S
Q
-
G
--
I
------
D
--
L
I
V
F
D
N
L
S
R
K
G
A
T
D
N
L
H
W
L
S
S
L
G
N
---
F
E
F
V
H
-
G
-
D
I----
R
N
--
K
---
N
-
D
V
T
R
L
I
T
K
---
Y
--
M
P
D
S
C
F
H
-
L
A
G
Q
V
A
M
-----------
T
T
S
I
D
N
P
C
M
D
F
E
I
N
V
G
G
T
L
N
L
L
E
A
V
R
Q
Y
--------
N
S
N
C
N
I
I
Y
S
S
T
N
K
V
Y
G
D
L
E
-
Q
Y
K
Y
N
E
T
ETRYTCVDKP
N
G
Y
D
E
S
T
------
Q
--
L
D
F
H
-
S
P
Y
G
-------
C
S
K
G
A
A
D
Q
-
Y
M
L
D
Y
A
-----
R
I
-
F
G
L
N
T
V
V
F
R
----
H
S
S
M
Y
G
G
R
Q
--
F
ATYDQG--
W
-----------
V
-------
G
W
----
F
---
C
Q
----
K
A
V
E
I
K
-----
N
-
G
IN
K
--
P
F
T
I
----
S
------
G
N
G
K
Q
V
R
D
V
L
H
A
E
D
M
I
S
L
Y
F
T
A
L
A
N
V
SK--
I
----
R
G
N
A
F
N
I
G
G
T
IV
N
-
S
L
S
L
L
E
L
F
K
L
L
E
D
Y
C
N
I
D
M
R
F
-
T
-
N
--
L
P
V
R
------------------------
E
S
--
D
Q
R
V
F
V
A
D
I
K
K
I
T
N
A
I
D
W
S
P
K
V
-
S
A
K
D
G
V
Q
K
M
Y
D
----
29
HHSearch
66.23
18%
-76
- C1 -
3VPS
2
?
A:
[8-300]
--
H
R
I
L
I
T
G
G
A
G
F
I
G
G
H
L
A
R
A
L
V
A
S
-
G
--
E
------
E
--
V
T
V
L
D
D
L
R
V
P
P
M
IPPE------
G
T
---
G
---
K
-
F
L
E
-----
K
P
--
V
---
L
E
L
E
E
R
D
L
S
-------
D
V
R
L
V
Y
H
-
L
A
S
H
K
S
V
-----------
P
R
S
F
K
Q
P
-
L
D
Y
L
D
N
V
D
S
G
R
H
L
L
A
L
C
T
S
V
---------
G
V
P
K
V
V
V
G
S
T
C
E
V
Y
G
Q
A
D
-
T
----------------
L
P
T
P
E
D
S
------
P
--
L
S
P
R
-
S
P
Y
A
-------
A
S
K
V
G
L
E
M
-
V
A
G
A
H
Q
-----
R
A
S
V
A
P
E
V
G
I
V
R
----
F
F
N
V
Y
G
P
G
E
--
R
PDA-----
L
-----------
V
-------
P
R
----
L
---
C
A
----
N
L
---
L
-----
T
-
R
--
N
E
-
L
-
P
V
----
E
------
G
D
G
E
Q
R
R
D
F
T
Y
I
T
D
V
V
D
K
L
V
A
L
A
N
R
P
---------
L
P
S
V
V
N
F
G
S
G
--
Q
-
S
L
S
V
N
D
V
I
R
I
L
Q
A
T
S
P
A
A
E
V
--
A
-
R
--
K
Q
P
R
----------
P
-----
N
--
E
---------
I
T
E
F
R
A
D
T
A
L
Q
T
R
Q
I
G
E
R
S
G
G
I
G
I
E
E
G
I
R
L
T
L
E
----
4
PsiBlast_PDB
66.05
23%
-87
- C1 -
4GLL
3
UXS1_HUMAN
A:
[8-243]
----
I
L
I
T
G
G
A
G
F
V
G
S
H
L
T
D
K
L
M
M
D
-
G
--
H
------
E
--
V
T
V
V
D
N
F
F
T
G
R
K
----------
R
N
---
V
E--
H
-
W
-
I
GHEN
F
E
L
--
I
---
N
H
D
V
V
E
P
L
Y
----
I
--
E
V
D
Q
I
Y
H
-
L
A
S
P
A
-
S
-------
P
--
P
N
Y
M
Y
N
P
I
K
T
L
K
T
N
T
I
-
G
T
L
N
M
L
G
L
A
K
R
V
G
-------
A
R
L
L
L
-----------
A
S
T
-
S
E
---------------
V
Y
G
D
P
E
V
H
-----
P
--
Q
-
S
E
-
D
Y
W
G
H
V
N
PIGP
R
A
C
Y
D
E
G
K
-
R
V
A
E
T
M
C
Y
A
Y
M
K
Q
-
E
G
V
E
V
R
V
A
R
IFNT
F
G
P
R
M
H
M
N
D
--
G
--------
R
-----------
V
--------
V
----
S
---
N
F
----
I
L
---
Q
-----
A
-
L
--
Q
--
G
-
E
P
LTV-
Y
------
G
S
G
S
Q
T
R
A
F
Q
Y
V
S
D
L
V
N
G
L
V
A
L
M
N
-
S
----
N
----
V
S
S
P
V
N
L
G
N
P
-----------------------------------------------------------------------------------------------------
40
HHSearch
65.93
14%
-84
- C1 -
2HUN
1
?
A:
[4-308]
--
M
K
L
L
V
T
G
G
M
G
F
I
G
S
N
F
I
R
Y
I
L
E
K
-
H
P
D
W
------
E
--
V
I
N
I
D
K
L
G
Y
G
S
N
PANLKDLEDD
P
R
---
Y
T
F
V
K
-
G
-
D
V----
A
D
--
Y
----
E
L
V
K
E
L
V
R
-------
K
V
D
G
V
V
H
-
L
A
A
E
S
H
V
-----------
D
R
S
I
S
S
P
E
I
F
L
H
S
N
V
I
G
T
Y
T
L
L
E
S
I
R
R
E
--------
N
P
E
V
R
F
V
H
V
S
T
D
E
V
Y
G
D
I
L
-
K
----------------
G
S
F
T
E
N
D
------
R
--
L
M
P
S
-
S
P
Y
S
-------
A
T
K
A
A
S
D
M
-
L
V
L
G
W
T
-----
R
T
-
Y
N
L
N
A
S
I
T
R
----
C
T
N
N
Y
G
P
Y
Q
--
F
PEK-----
L
-----------
I
-------
P
K
----
T
---
I
I
----
R
A
---
S
-----
L
-
G
--
L
K
-
I
-
P
I
----
Y
------
G
T
---
V
R
D
W
L
Y
V
E
D
H
V
R
A
I
E
L
V
L
L
K
G
----
E
----
S
R
E
I
Y
N
I
S
A
G
--
E
-
E
K
T
N
L
E
V
V
K
I
I
L
R
L
M
G
K
G
E
E
L-
I
-
E
--
L
V
E
D
----------------
R
--
P
-----
G
--
H
D
L
R
Y
S
L
D
S
W
K
I
T
R
D
L
K
W
R
P
K
Y
-
T
F
D
E
G
I
K
K
T
I
-----
24
HHSearch
65.17
16%
-85
- C1 -
2BLL
-
ARNA_ECOLI
A:
[316-647]
--
M
R
V
L
I
L
G
V
N
G
F
I
G
N
H
L
T
E
R
L
L
R
E
D
H
--
Y
------
E
--
V
Y
G
L
D
I
G
S
D
A
I
S
RFLNH-----
P
H
F
H
F
V
---
E
-
G
-
D
I----
S
I
--
H
---
S
E
W
I
E
Y
H
V
K
-------
K
C
D
V
V
L
P
-
L
V
A
I
A
T
P
-----------
I
E
Y
T
R
N
P
L
R
V
F
E
L
D
F
E
E
N
L
R
I
I
R
Y
C
V
K
----------
Y
R
K
R
I
I
F
P
S
T
S
E
V
Y
G
M
C
S
-
D
----------------
K
Y
F
D
E
D
H
S
N
L
I
V
G
P
VN
K
-
P
R
-
W
I
Y
S
-------
V
S
K
Q
L
L
D
R
-
V
I
W
A
Y
G
-----
E
K
-
E
G
L
Q
F
T
L
F
R
----
P
F
N
W
M
G
P
R
L
--
D
--------
N
LNAARIGSS
R
A
I
-------
T
Q
----
L
---
I
L
----
N
L
---
V
-----
E
-
G
--
S
--
P
I
K
L
----
I
------
D
G
G
K
Q
K
R
C
F
T
D
I
R
D
G
I
E
A
L
Y
R
I
I
E
N
A
GNR-
C
----
D
G
E
I
I
N
I
G
N
P
--
E
N
E
A
S
I
E
E
L
G
E
M
L
L
A
S
F
E
K
H
P
L
R-
H
-
H
--
F
P
P
F
A
G
-----
F
R
V
V
------------------
V
E
H
R
K
P
S
I
R
N
A
H
R
C
L
D
W
E
P
K
I
-
D
M
Q
E
T
I
D
E
T
L
D
----
42
HHSearch
65.07
14%
-84
- C1 -
1KEW
5
RMLB_SALTY
A:
[1-331]
--
M
K
I
L
I
T
G
G
A
G
F
I
G
S
A
V
V
R
H
I
I
K
N
-
T
--
Q
------
D
T
-
V
V
N
I
D
K
L
T
Y
A
G
N
LESLSDISES
N
R
Y
N
F
E
---
H
-
A
-
D
I----
C
D
--
S
---
A
-
E
I
T
R
I
F
E
Q
---
Y
--
Q
P
D
A
V
M
H
-
L
A
A
E
S
H
V
-----------
D
R
S
I
T
G
P
A
A
F
I
E
T
N
I
V
G
T
Y
A
L
L
E
V
A
R
K
Y
W
S
A
LG
E
D
K
K
N
N
F
R
F
H
H
I
S
T
D
E
V
Y
G
D
L
P
-
H
P
DEVENS
V
T
L
------
P
L
F
T
E
T
T
------
A
--
Y
A
P
S
-
S
P
Y
S
-------
A
S
K
A
S
S
D
H
-
L
V
R
A
W
R
-----
R
T
-
Y
G
L
P
T
I
V
T
N
----
C
S
N
N
Y
G
P
Y
H
--
F
PEK-----
L
-----------
I
-------
P
L
----
V
---
I
L
----
N
A
---
L
-----
E
-
G
--
K
P-
L
-
P
I
----
Y
------
G
K
G
D
Q
I
R
D
W
L
Y
V
E
D
H
A
R
A
L
H
M
V
V
T
E
G
----
K
----
A
G
E
T
Y
N
I
G
G
H
--
N
-
E
K
K
N
L
D
V
V
F
T
I
C
D
L
L
D
E
I
V
P
KA
T
-
S
--
Y
R
E
Q
I
------
T
Y
V
------
A
--
D
--
R
-
P
G
--
H
D
R
R
Y
A
I
D
A
G
K
I
S
R
E
L
G
W
K
P
L
E
-
T
F
E
S
G
I
R
K
T
V
-----
27
HHSearch
65.00
14%
-90
- C1 -
2Z1M
2
?
A:
[4-331]
--
K
R
A
L
I
T
G
I
R
G
Q
D
G
A
Y
L
A
K
L
L
L
E
K
-
G
--
Y
------
E
--
V
Y
G
A
D
R
R
S
G
E
F
A
S
W
R
L
K
E
L
GIE
N
D
V
K
I
I
---
H
-
M
-
D
L----
L
E
--
F
---
S
N
-
I
I
R
T
I
E
K
---
V
--
Q
P
D
E
V
Y
N
-
L
A
A
Q
S
F
V
-----------
G
V
S
F
E
Q
P
I
L
T
A
E
V
D
A
I
G
V
L
R
I
L
E
A
L
R
T
V
--------
K
P
D
T
K
F
Y
Q
A
S
T
S
E
M
F
G
K
V
Q
-
E
----------------
I
P
Q
T
E
K
T
------
P
--
F
Y
P
R
-
S
P
Y
A
-------
V
A
K
L
F
G
H
W
-
I
T
V
N
Y
R
-----
E
A
-
Y
N
M
F
A
C
S
G
I
----
L
F
N
H
E
S
P
L
R
--
G
IE------
F
-----------
V
-------
T
R
K
---
I
T
Y
S
L
A
----
R
I
---
K
-----
Y
-
G
--
L
QD
K
-
L
V
----
L
------
G
N
L
N
A
K
R
D
W
G
Y
A
P
E
Y
V
E
A
M
W
L
M
M
Q
Q
P
---------
E
P
D
D
Y
V
I
A
T
G
--
E
-
T
H
T
V
R
E
F
V
E
K
A
A
K
I
A
G
F
D
I
E
W
-
V
-
G
EG
I
N
E
K
G
I
DRNTG
K
V
I
V
-----
E
V
S
E
EF
F
R
P
A
--
E
V
D
I
L
V
G
N
P
E
K
A
M
K
K
L
G
W
K
P
R
T
-
T
F
D
E
L
V
E
I
M
M
-----
38
HHSearch
64.66
16%
-85
- C1 -
2C20
2
?
A:
[2-318]
--
N
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
-
G
--
L
------
S
--
V
V
V
V
D
N
L
Q
T
G
H
E
DAIT------
E
G
A
K
F
Y
---
N
-
G
-
D
L----
R
D
--
K
---
A
F
-
L
R
D
V
F
T
Q
---
E
--
N
I
E
A
V
M
H
-
F
A
A
D
S
L
V
-----------
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
D
E
F
---------
K
V
D
K
F
I
F
S
S
T
A
A
T
Y
G
E
V
D
-
V
----------------
D
L
I
T
E
E
T
------
M
--
T
N
P
T
-
N
T
Y
G
-------
E
T
K
L
A
I
E
K
-
M
L
H
W
Y
S
-----
Q
A
-
S
N
L
R
Y
K
I
F
R
----
Y
F
N
V
A
G
A
T
P
--
N
--------
G
I----------
I
GEDHRPE
T
H
----
L
---
I
P
L
V
L
Q
V
A
---
L
G----
Q
-
R
--
E
--
K
I
M
M
----
F
G
DDYNT
P
D
G
T
C
I
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
G-
G
----
E
S
D
F
Y
N
L
G
N
G
--
N
-
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
E
I
P
--
A
E
V
--
A
P
R
R
----------
A
-----
G
--
D
---------
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
P
R
Y
V
N
V
K
T
I
I
E
H
A
W
-----
37
HHSearch
64.51
16%
-75
- C1 -
1OC2
4
?
A:
[5-320]
--
K
N
I
I
V
T
G
G
A
G
F
I
G
S
N
F
V
H
Y
V
Y
N
N
-
H
--
P
------
D
V
H
V
T
V
L
D
K
L
T
Y
A
G
N
KANLEAILG-
D
R
---
V
E
L
V
V
-
G
-
D
I----
A
D
--
A
---
E
-
L
V
D
K
L
A
A
-------
K
A
D
A
I
V
H
-
Y
A
A
E
S
H
N
-----------
D
N
S
L
N
D
P
S
P
F
I
H
T
N
F
I
G
T
Y
T
L
L
E
A
A
R
K
Y
---------
D
-
I
R
F
H
H
V
S
T
D
E
V
Y
G
D
L
P
-
L
R
EDLPGHGEGPG----
E
K
F
T
A
E
T
------
N
--
Y
N
P
S
-
S
P
Y
S
-------
S
T
K
A
A
S
D
L
-
I
V
K
A
W
V
-----
R
S
-
F
G
V
K
A
T
I
S
N
----
C
S
N
N
Y
G
P
Y
Q
--
H
IEK-----
F
-----------
I
-------
P
R
----
Q
---
I
T
----
N
I
---
L
-----
A
-
G
--
I
--
K
P
K
L
----
Y
------
G
E
G
K
N
V
R
D
W
I
H
T
N
D
H
S
T
G
V
W
A
I
L
T
K
G
----
R
----
M
G
E
T
Y
L
I
G
A
D
--
G
-
E
K
N
N
K
E
V
L
E
L
I
L
E
K
M
G
Q
P
K
D
--
A
-
Y
--
D
H
V
T
-------
D
R
-
A
-----
G
-----------
H
D
L
R
Y
A
I
D
A
S
K
L
R
D
E
L
G
W
T
P
Q
F
T
D
F
S
E
G
L
E
E
T
I
Q
----
39
HHSearch
64.00
15%
-94
- C1 -
2X4G
-
?
A:
[13-331]
--
V
K
Y
A
V
L
G
A
T
G
L
L
G
H
H
A
A
R
A
I
R
A
A
-
G
--
H
------
D
--
L
V
L
I
H
R
P
S
S
Q
I
Q
RLAYLE
P
---
E
C
---
R
---
V
-
A
-
E
M----
L
D
--
H
---
A
G
-
L
E
R
A
L
R
-------
G
L
D
G
V
I
F
-
S
-------------------------
E
E
V
A
S
A
L
G
Q
T
N
P
F
Y
A
A
C
L
Q
A
---------
R
V
P
R
I
L
Y
V
G
S
A
Y
A
M
P
R
H
P
-
Q
G
---------------
L
P
G
H
E
G
L
F
YDS--
L
--
P
S
G
K
-
S
S
Y
V
-------
L
C
K
W
A
L
D
E
-
Q
A
R
E
Q
------
A
R
-
N
G
L
P
V
V
I
G
I
----
P
G
M
V
L
G
E
L
D
I-
G
P-------
T
-----------
T
-------
G
R
----
V
---
I
T
----
A
I
---
G
-----
N
-
G
--
E
--
M
-
T
H
----
Y
--------
V
A
G
Q
R
N
V
I
D
A
A
E
A
G
R
G
L
L
M
A
L
E
R
G
----
R
----
I
G
E
R
Y
L
L
T
G
---
H
-
N
L
E
M
A
D
L
T
R
R
I
A
E
L
L
G
Q
P
A
P
--
Q
-
P
--
M
S
M
A
M
A
-----
R
A
L
A
T
L
G
R
L--------
E
V
--
M
A
G
G
Q
F
L
D
G
R
K
A
R
E
E
L
G
F
F
S
T
T
-
A
L
D
D
T
L
L
R
A
I
D
----
10
PsiBlast_PDB
63.94
23%
-84
- C1 -
2B69
3
UXS1_HUMAN
A:
[30-265]
----
I
L
I
T
G
G
A
G
F
V
G
S
H
L
T
D
K
L
M
M
D
-
G
--
H
------
E
--
V
T
V
V
D
N
F
F
T
G
R
K
----------
R
N
---
V
E--
H
-
W
-
I
GHEN
F
E
L
--
I
---
N
H
D
V
V
E
P
L
Y
----
I
--
E
V
D
Q
I
Y
H
-
L
A
S
P
A
-
S
-------
P
--
P
N
Y
M
Y
N
P
I
K
T
L
K
T
N
T
I
-
G
T
L
N
M
L
G
L
A
K
R
V
G
-------
A
R
L
L
L
-----------
A
S
T
-
S
E
---------------
V
Y
G
D
P
E
V
H
-----
P
--
Q
-
S
E
-
D
Y
W
G
H
V
N
PIGP
R
A
C
Y
D
E
G
K
-
R
V
A
E
T
M
C
Y
A
Y
M
K
Q
-
E
G
V
E
V
R
V
A
R
I
F
N
T
F
G
P
R
M
H
M
N
D
--
G
--------
R
-----------
V
--------
V
----
S
---
N
F
----
I
L
---
Q
-----
A
-
L
--
Q
--
G
-
E
P
LTV-
Y
------
G
S
G
S
Q
T
R
A
F
Q
Y
V
S
D
L
V
N
G
L
V
A
L
M
N
-
S
----
N
----
V
S
S
P
V
N
L
G
N
P
-----------------------------------------------------------------------------------------------------
32
HHSearch
63.64
15%
-99
- C1 -
1EQ2
2
HLDD_ECOLI
A:
[1-303]
---
M
I
I
V
T
G
G
A
G
F
I
G
S
N
I
V
K
A
L
N
D
K
-
G
--
I
------
T
D-
I
L
V
V
D
N
L
K
D
G
T
K
FV--------
N
L
---
V
---
D
-
L
-
N
I----
A
D
--
Y
M
D
K
E
D
F
L
I
Q
I
M
A
G
EEF
G
--
D
V
E
A
I
F
H
-
E
G
A
C
S
S
T
-------------
T
E
W
D
G
K
Y
M
M
D
N
N
Y
Q
Y
S
K
E
L
L
H
Y
C
L
E
R
----------
E
I
P
F
L
Y
A
S
S
A
A
T
Y
G
G
R
T
-
S
-----------------
D
F
I
E
S
R
E
-----
Y
--
E
K
P
L
-
N
V
Y
G
-------
Y
S
K
F
L
F
D
E
-
Y
V
R
Q
I
L-----
P
E
-
A
N
S
Q
I
V
G
F
R
----
Y
F
N
V
Y
G
P
R
E
--
G
--------
H
KGS--------
M
-------
A
S
V
A
F
H
L
---
N
T
----
Q
L
---
N
-----
N
---------------------------
K
R
D
F
V
Y
V
G
D
V
A
D
V
N
L
W
F
L
E
N
-----
G
----
V
S
G
I
F
N
L
G
T
G
--
R
-
A
E
S
F
Q
A
V
A
D
A
T
------------------------------------------------
Y
Q
A
F
T
Q
A
D
L
T
N
L
R
-
A
A
G
Y
D
K
P
F
K
T
V
A
E
G
V
T
E
Y
M
-----
33
HHSearch
63.58
15%
-77
- C1 -
2YY7
6
?
A:
[3-309]
--
P
K
I
L
I
I
G
A
C
G
Q
I
G
T
E
L
T
Q
K
L
R
K
L
Y
G
--
T
E-----
N
--
V
I
A
S
D
I
R
K
L
N
T
D
V
V
N
S
------
G
P
---
F
---
E
V
V
-
N
A----
L
D
--
F
---
N
Q
-
I
E
H
L
V
E
V
---
H
--
K
I
T
D
I
Y
L
-
M
A
A
L
L
S
A
------------
T
A
E
K
N
P
A
F
A
W
D
L
N
M
N
S
L
F
H
V
L
N
L
A
K
A
K
---------
K
I
K
K
I
F
W
P
S
S
I
A
V
F
G
P
T
T
-
P
K
---------------
E
N
T
P
Q
Y
T
I
-----
M
--
E
-
P
S
-
T
V
Y
G
-------
I
S
K
Q
A
G
E
R
-
W
C
E
Y
Y
H
-----
N
I
-
Y
G
V
D
V
R
S
I
R
----
Y
P
G
L
I
S
W
S
T
--
P
PGGGTTD
Y
A
-----------
V
-------
D
I
----
F
---
Y
K
----
A
I
---
A
-----
D
-
K
--
K
--
Y
-
E
C
----
F
------
L
S
S
E
T
K
M
P
M
M
Y
M
D
D
A
I
D
A
T
I
N
I
M
K
A
P
----
V
EKIK
I
H
S
S
Y
N
L
A
A
M
----
S
F
T
P
T
E
I
A
N
E
I
K
K
H
I
P
E
F
T
I
--
T
-
Y
--
E
P
D
F
R
Q
-----------------
K
--
I
--
A
--
D
S
W
P
A
S
I
D
D
S
Q
A
R
E
D
W
D
W
K
H
T
F
-
D
L
E
S
M
T
K
D
M
I
E
----
8
PsiBlast_PDB
63.17
21%
-73
- C1 -
3EHE
1
?
A:
[4-260]
----
I
V
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
S
E
S
----
N
------
E
--
I
V
V
I
D
N
L
S
S
G
N
E
-----------------------------
E
F
--
V
---
N
E
A
A
R
L
V
K
A
D
---
L
--
A
A
D
D
I
K
D
Y
L
K
G
A
E
E
V
WHIAANP
D
--
V
R
-
G
A
E
N
P
D
E
I
Y
R
N
N
V
L
A
T
Y
R
L
L
E
A
M
R
K
A
G
-------
V
S
R
I
V
F
T
S
T
S
T
V
--
Y
G
E
A
K
--
V
---------------
I
P
T
P
E
D
Y
P
-----
T
--
H
-
P
I
-
S
L
Y
G
-------
A
S
K
L
A
C
E
A
L
I
E
S
Y
C
------
H
T
-
F
D
M
Q
A
W
I
Y
R
----
F
A
N
V
I
G
R
R
S
--
T
--------
H
-----------
G
-------
V
I
----
Y
---
D
F
----
I
M
---
K
-----
L
-
K
--
R
--
N
-
P
E
E
L
E
I
L
------
G
N
G
E
Q
N
K
S
Y
I
Y
I
S
D
C
V
D
A
M
L
F
G
L
R
G
D
----
E
----
R
V
N
I
F
N
I
G
S
E
--
D
-
Q
I
K
V
K
R
I
A
E
I
V
C
E
E
L
----------------------------------------------------------------------------------