@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2460: (2016-04-03 )
MSDLINIQKKLLPDVLMIMQKRYQILRSIYFSEPVGRRTLAGMLGMSERVLRGEVEFLKAQGLVEIASSGMTVTKEGLVVFRDLESVMNQLSGLHSMEEQLAKKLQIKKCLVVQGDSDDTPWVREEMGRVAVEQLDMALTEKRNIVAVMGGSTMATVAEMMTTDFAKGRELLFVPGRGGIGEDLDNQANTICDKMATKTNTKHRVLYVPEQLGEEAYRSLLKEPAIQEGLRLVQSANAIILGIGDALAMAKRRHTGEDVLEKIIHRKAVGEAFGYYFDEQGEVVHKVPTFGLQFEDLAQIPHIIAVAGGTSKAKAIKSYMKSAPKNTILITDEGAAKSLLKGSNTLLK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120........130---.......140......-.150.......160.......170.......180.-.-..--.--..190.......200.......210---.-..-....220...-....230.......240..-----.....---250....----...260.......270.....----..280...---....----290.......300.......310.......320..-.....330.......340......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
D
L
I
N
I
Q
K
K
L
L
P
D
V
L
M
I
M
Q
K
R
Y
Q
I
L
R
S
I
YFSEPVG
R
R
T
L
A
G
M
LG
M
S
E
R
V
L
R
G
E
V
E
F
L
K
AQ
G
L
V
E
I
A
SSG
M
T
V
TKE
G
L
V
V
F
R
D
L
E
S
V
M
N
Q
L
S
G
L
H
S
M
E
E
Q
L
A
K
K
L
Q
I
K
K
C
L
V
V
QGDSDDT-
P
W
V
R
E
E
M
G
R
V
A
V
---
E
Q
L
D
M
A
L
TEKR
N
I
V
A
V
-MGG
S
T
M
A
T
V
A
E
M
M
T
T
D
F
AKG
R
E
L
L
F
VPGRGGIGE
D
-
L
-
D
N
--
Q
--
A
N
T
I
C
D
K
M
ATKTNT
K
H
R
V
L
Y
V
P
E
Q
L
---
G
-
E
E
-
A
Y
R
S
L
L
K
E
P
A
-
I
Q
E
G
L
R
L
V
QSA
N
A
I
I
L
GI
G
-----
D
A
L
A
M
---
A
K
RRHT
G
----
E
D
V
L
E
K
I
I
H
R
K
A
V
G
E
A
F
G
YYF----DEQG
E
V
V
H
---KVPT----FGL
Q
F
E
D
L
AQI
P
H
I
I
A
VAGGT
S
K
A
K
A
I
K
S
Y
M
K
SAP-K
N
T
I
L
I
TDE
G
A
A
K
S
L
L
KGSNTLLK
21
PsiBlast_CBE
98.58
54%
-102
- C4 -
3BXH
2
CGGR_BACSU
B:
[8-253]
--------------------------------------------------------------------------------------------
G
L
T
L
L
E
K
T
L
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
-
P
W
V
K
K
E
M
G
R
A
A
V
---
A
C
M
K
K
R
F
S
G
K
-
N
I
V
A
V
-
T
G
G
T
T
I
E
A
V
A
E
M
M
T
P
D
-
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
E
D
-
V
-
K
N
--
Q
--
A
N
T
I
C
A
H
M
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
G
Q
L
---
S
-
Q
G
-
A
Y
S
S
I
I
E
E
P
S
-
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
-----
E
A
K
T
M
---
A
Q
R
R
N
T
P
----
L
E
D
L
K
K
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
----
N
A
D
G
E
V
V
H
---
K
V
H
S
----
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
F
K
K
-
P
-
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
-------
24
PsiBlast_CBE
98.04
54%
-102
- C4 -
3BXE
1
CGGR_BACSU
B:
[8-253]
--------------------------------------------------------------------------------------------
G
L
T
L
L
E
K
T
L
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
-
P
W
V
K
K
E
M
G
R
A
A
V
---
A
C
M
K
K
R
F
S
G
K
-
N
I
V
A
V
-
T
G
G
T
T
I
E
A
V
A
E
M
M
T
P
D
-
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
E
D
-
V
-
K
N
--
Q
--
A
N
T
I
C
A
H
M
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
G
Q
L
---
S
-
Q
G
-
A
Y
S
S
I
I
E
E
P
S
-
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
-----
E
A
K
T
M
---
A
Q
R
R
N
T
P
----
L
E
D
L
K
K
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
----
N
A
D
G
E
V
V
H
---
K
V
H
S
----
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
F
K
K
-
P
-
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
-------
22
PsiBlast_CBE
97.94
54%
-102
- C4 -
3BXG
1
CGGR_BACSU
B:
[8-253]
--------------------------------------------------------------------------------------------
G
L
T
L
L
E
K
T
L
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
-
P
W
V
K
K
E
M
G
R
A
A
V
---
A
C
M
K
K
R
F
S
G
K
-
N
I
V
A
V
-
T
G
G
T
T
I
E
A
V
A
E
M
M
T
P
D
-
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
E
D
-
V
-
K
N
--
Q
--
A
N
T
I
C
A
H
M
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
G
Q
L
---
S
-
Q
G
-
A
Y
S
S
I
I
E
E
P
S
-
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
-----
E
A
K
T
M
---
A
Q
R
R
N
T
P
----
L
E
D
L
K
K
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
----
N
A
D
G
E
V
V
H
---
K
V
H
S
----
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
F
K
K
-
P
-
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
-------
3
PsiBlast_PDB
97.26
54%
-103
- C4 -
3BXF
2
CGGR_BACSU
A:
[8-253]
--------------------------------------------------------------------------------------------
G
L
T
L
L
E
K
T
L
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
-
P
W
V
K
K
E
M
G
R
A
A
V
---
A
C
M
K
K
R
F
S
G
K
-
N
I
V
A
V
-
T
G
G
T
T
I
E
A
V
A
E
M
M
T
P
D
-
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
E
D
-
V
-
K
N
--
Q
--
A
N
T
I
C
A
H
M
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
G
Q
L
---
S
-
Q
G
-
A
Y
S
S
I
I
E
E
P
S
-
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
-----
E
A
K
T
M
---
A
Q
R
R
N
T
P
----
L
E
D
L
K
K
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
----
N
A
D
G
E
V
V
H
---
K
V
H
S
----
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
F
K
K
-
P
-
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
-------
5
PsiBlast_PDB
97.10
54%
-104
- C4 -
3BXH
2
CGGR_BACSU
A:
[8-253]
--------------------------------------------------------------------------------------------
G
L
T
L
L
E
K
T
L
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
-
P
W
V
K
K
E
M
G
R
A
A
V
---
A
C
M
K
K
R
F
S
G
K
-
N
I
V
A
V
-
T
G
G
T
T
I
E
A
V
A
E
M
M
T
P
D
-
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
E
D
-
V
-
K
N
--
Q
--
A
N
T
I
C
A
H
M
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
G
Q
L
---
S
-
Q
G
-
A
Y
S
S
I
I
E
E
P
S
-
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
-----
E
A
K
T
M
---
A
Q
R
R
N
T
P
----
L
E
D
L
K
K
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
----
N
A
D
G
E
V
V
H
---
K
V
H
S
----
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
F
K
K
-
P
-
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
-------
4
PsiBlast_PDB
97.02
54%
-100
- C4 -
3BXG
1
CGGR_BACSU
A:
[8-253]
--------------------------------------------------------------------------------------------
G
L
T
L
L
E
K
T
L
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
-
P
W
V
K
K
E
M
G
R
A
A
V
---
A
C
M
K
K
R
F
S
G
K
-
N
I
V
A
V
-
T
G
G
T
T
I
E
A
V
A
E
M
M
T
P
D
-
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
E
D
-
V
-
K
N
--
Q
--
A
N
T
I
C
A
H
M
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
G
Q
L
---
S
-
Q
G
-
A
Y
S
S
I
I
E
E
P
S
-
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
-----
E
A
K
T
M
---
A
Q
R
R
N
T
P
----
L
E
D
L
K
K
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
----
N
A
D
G
E
V
V
H
---
K
V
H
S
----
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
F
K
K
-
P
-
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
-------
2
PsiBlast_PDB
96.92
54%
-102
- C4 -
3BXE
1
CGGR_BACSU
A:
[8-253]
--------------------------------------------------------------------------------------------
G
L
T
L
L
E
K
T
L
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
-
P
W
V
K
K
E
M
G
R
A
A
V
---
A
C
M
K
K
R
F
S
G
K
-
N
I
V
A
V
-
T
G
G
T
T
I
E
A
V
A
E
M
M
T
P
D
-
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
E
D
-
V
-
K
N
--
Q
--
A
N
T
I
C
A
H
M
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
G
Q
L
---
S
-
Q
G
-
A
Y
S
S
I
I
E
E
P
S
-
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
-----
E
A
K
T
M
---
A
Q
R
R
N
T
P
----
L
E
D
L
K
K
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
----
N
A
D
G
E
V
V
H
---
K
V
H
S
----
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
F
K
K
-
P
-
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
-------
23
PsiBlast_CBE
95.82
54%
-99
- C4 -
3BXF
5
CGGR_BACSU
B:
[9-253]
---------------------------------------------------------------------------------------------
L
T
L
L
E
K
T
L
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
-
P
W
V
K
K
E
M
G
R
A
A
V
---
A
C
M
K
K
R
F
S
G
K
-
N
I
V
A
V
-
T
G
G
T
T
I
E
A
V
A
E
M
M
T
P
D
-
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
E
D
-
V
-
K
N
--
Q
--
A
N
T
I
C
A
H
M
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
G
Q
L
---
S
-
Q
G
-
A
Y
S
S
I
I
E
E
P
S
-
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
-----
E
A
K
T
M
---
A
Q
R
R
N
T
P
----
L
E
D
L
K
K
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
----
N
A
D
G
E
V
V
H
---
K
V
H
S
----
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
F
K
K
-
P
-
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
-------
29
HHSearch
95.05
54%
-104
- C4 -
2OKG
3
CGGR_BACSU
A:
[7-253]
-------------------------------------------------------------------------------------------
L
G
L
T
L
L
E
K
T
L
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
-
P
W
V
K
K
E
M
G
R
A
A
V
---
A
C
M
K
K
R
F
S
G
K
-
N
I
V
A
V
-
T
G
G
T
T
I
E
A
V
A
E
M
M
T
P
D
S
K
-
N
R
E
L
L
F
V
P
A
R
G
G
L
G
-----
K
N
--
Q
--
A
N
T
I
C
A
H
M
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
G
Q
L
---
S
-
Q
G
-
A
Y
S
S
I
I
E
E
P
S
-
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
-----
E
A
K
T
M
---
A
Q
R
R
N
T
P
----
L
E
D
L
K
K
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
----
N
A
D
G
E
V
V
H
---
K
V
H
S
----
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
F
K
K
-
P
-
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
-------
6
PsiBlast_PDB
94.82
52%
-104
- C4 -
2OKG
3
CGGR_BACSU
A:
[8-253]
--------------------------------------------------------------------------------------------
G
L
T
L
L
E
K
T
L
K
E
R
L
N
L
K
D
A
I
I
V
S
G
D
S
D
Q
S
-
P
W
V
K
K
E
M
G
R
A
A
V
---
A
C
M
K
K
R
F
S
G
K
-
N
I
V
A
V
-
T
G
G
T
T
I
E
A
V
A
E
M
M
T
P
D
-
S
K
N
R
E
L
L
F
V
P
A
R
G
G
L
G
-----
K
N
--
Q
--
A
N
T
I
C
A
H
M
A
E
K
A
S
G
T
Y
R
L
L
F
V
P
G
Q
L
---
S
-
Q
G
-
A
Y
S
S
I
I
E
E
P
S
-
V
K
E
V
L
N
T
I
K
S
A
S
M
L
V
H
G
I
G
-----
E
A
K
T
M
---
A
Q
R
R
N
T
P
----
L
E
D
L
K
K
I
D
D
N
D
A
V
T
E
A
F
G
Y
Y
F
----
N
A
D
G
E
V
V
H
---
K
V
H
S
----
V
G
M
Q
L
D
D
I
D
A
I
P
D
I
I
A
V
A
G
G
S
S
K
A
E
A
I
E
A
Y
F
K
K
-
P
-
R
N
T
V
L
V
T
D
E
G
A
A
K
K
L
L
R
-------
1
PsiBlast_PDB
91.42
48%
-96
- C4 -
2O0M
2
?
A:
[95-341]
----------------------------------------------------------------------------------------------
H
Q
I
E
K
E
M
T
Q
Y
F
G
I
Q
R
C
I
V
V
A
G
D
S
D
I
Q
-
K
K
V
L
S
D
F
G
D
V
L
T
---
N
T
L
N
L
L
L
P
N
G
E
N
T
I
A
V
-
M
G
G
T
T
M
A
M
V
A
E
N
M
G
S
L
E
T
E
K
R
H
N
L
F
V
P
A
R
G
G
I
G
E
A
-
V
-
S
V
--
Q
--
A
N
S
I
S
A
V
M
A
N
K
T
G
G
N
Y
R
A
L
Y
V
P
E
Q
L
---
S
-
R
E
-
T
Y
N
S
L
L
Q
E
P
S
-
I
Q
E
V
L
T
L
I
S
H
A
N
C
V
V
H
S
I
G
-----
R
A
L
H
M
---
A
A
R
R
K
M
S
----
D
D
E
M
V
M
L
K
Q
K
N
A
V
A
E
S
F
G
Y
F
F
----
D
E
E
G
K
V
V
Y
---
K
I
P
R
----
I
G
L
Q
L
K
N
L
Q
E
I
P
Y
V
V
A
I
A
G
G
K
T
K
A
K
A
I
R
A
Y
M
K
N
A
P
-
K
Q
T
W
L
I
T
D
E
A
A
A
N
E
I
L
K
-------
25
HHSearch
91.08
48%
-95
- C4 -
2O0M
2
?
A:
[95-341]
----------------------------------------------------------------------------------------------
H
Q
I
E
K
E
M
T
Q
Y
F
G
I
Q
R
C
I
V
V
A
G
D
S
D
I
Q
-
K
K
V
L
S
D
F
G
D
V
L
T
---
N
T
L
N
L
L
L
P
N
G
E
N
T
I
A
V
-
M
G
G
T
T
M
A
M
V
A
E
N
M
G
S
L
E
T
E
K
R
H
N
L
F
V
P
A
R
G
G
I
G
E
A
-
V
-
S
V
--
Q
--
A
N
S
I
S
A
V
M
A
N
K
T
G
G
N
Y
R
A
L
Y
V
P
E
Q
L
---
S
-
R
E
-
T
Y
N
S
L
L
Q
E
P
S
-
I
Q
E
V
L
T
L
I
S
H
A
N
C
V
V
H
S
I
G
-----
R
A
L
H
M
---
A
A
R
R
K
M
S
----
D
D
E
M
V
M
L
K
Q
K
N
A
V
A
E
S
F
G
Y
F
F
----
D
E
E
G
K
V
V
Y
---
K
I
P
R
----
I
G
L
Q
L
K
N
L
Q
E
I
P
Y
V
V
A
I
A
G
G
K
T
K
A
K
A
I
R
A
Y
M
K
N
-
A
P
K
Q
T
W
L
I
T
D
E
A
A
A
N
E
I
L
K
-------
48
Fugue
80.92
19%
-90
- C4 -
2W48
3
SORC_KLEPN
A:
[4-315]
----------------
S
D
D
I
R
L
I
V
K
I
A
Q
L
Y
Y
E
Q
D
M
T
Q
A
Q
I
A
R
E
L
G
I
Y
R
T
T
I
S
R
L
L
K
R
G
R
E
Q
G
I
V
T
I
-------------------
A
I
N
Y
D
Y
N
E
N
L
W
L
E
Q
Q
L
K
Q
K
F
G
L
K
E
A
V
V
A
----
S
S
E
-
E
E
Q
L
S
A
M
G
Q
H
G
A
---
L
L
V
D
R
L
L
E
P
G
-
D
I
I
G
F
-
S
W
G
R
A
V
R
S
L
V
E
N
L
P
Q
R
-
S
Q
S
R
Q
V
I
C
V
P
I
I
G
G
P
S
G
K
-
L
-
E
S
--
R
YH
V
N
T
L
T
Y
G
A
A
A
R
L
K
A
E
S
H
L
A
D
F
P
A
L
L
---
D
N
P
L
-
I
R
N
G
I
M
Q
S
Q
H
-
F
K
T
I
S
S
Y
W
D
S
L
D
V
A
L
V
G
I
G
S
PA--
I
R
D
G
A
---
N
W
H
A
F
Y
G
----
S
E
E
S
D
D
L
N
A
R
H
V
A
G
D
I
C
S
R
F
Y
----
D
I
N
G
G
L
V
D
TNM
S
E
K
T
----
L
S
I
E
M
A
K
L
R
Q
A
R
Y
S
I
G
I
A
M
G
E
E
K
Y
S
G
I
L
G
A
L
H
G
R
Y
-
I
N
-
C
L
V
T
N
R
E
T
A
E
L
L
L
K
-------
26
HHSearch
78.17
19%
-88
- C4 -
2W48
3
SORC_KLEPN
A:
[9-315]
---------------------
L
I
V
K
I
A
Q
L
Y
Y
E
Q
D
M
T
Q
A
Q
I
A
R
E
L
G
I
Y
R
T
T
I
S
R
L
L
K
R
G
R
E
Q
G
I
V
T
I
A
I
N
Y
-------------------
D
Y
N
E
N
L
W
L
E
Q
Q
L
K
Q
K
F
G
L
K
E
A
V
V
A
S
S
----
E
-
E
E
Q
L
S
A
M
G
Q
H
G
A
---
L
L
V
D
R
L
L
E
P
G
-
D
I
I
G
F
-
S
W
G
R
A
V
R
S
L
V
E
N
L
P
Q
R
S
Q
-
S
R
Q
V
I
C
V
P
I
I
G
G
P
S
G
K
L
E
S
R
Y
--
H
--
V
N
T
L
T
Y
G
A
A
A
R
L
K
A
E
S
H
L
A
D
F
P
A
L
L
---
D
-
N
P
L
I
R
N
G
I
M
Q
S
Q
H
-
F
K
T
I
S
S
Y
W
D
S
L
D
V
A
L
V
G
I
G
-----
S
P
A
I
R
DGA
N
W
H
A
F
Y
G
----
S
E
E
S
D
D
L
N
A
R
H
V
A
G
D
I
C
S
R
F
Y
----
D
I
N
G
G
L
V
D
TNM
S
E
K
T
----
L
S
I
E
M
A
K
L
R
Q
A
R
Y
S
I
G
I
A
M
G
E
E
K
Y
S
G
I
L
G
A
L
H
G
-
R
-
Y
I
N
C
L
V
T
N
R
E
T
A
E
L
L
L
K
-------
11
PsiBlast_PDB
72.11
25%
-78
- C4 -
4L4Z
1
LSRR_ECOLI
A:
[18-265]
-------------------------------------------------------------------------------------------
E
G
C
L
E
Y
E
T
Q
L
R
R
Q
F
S
L
Q
H
V
R
V
I
P
G
L
A
D
A
D
-
V
G
G
R
L
G
I
G
---
A
---
A
H
M
L
M
S
L
L
Q
P
Q
Q
M
L
A
I
G
F
G
E
A
T
M
N
T
L
Q
R
L
--
S
G
F
I
S
S
Q
Q
I
R
L
V
T
L
S
G
G
V
G
S
Y
-
M
-
T
G
IG
Q
--
L
N
A
A
C
S
-----------
V
N
I
I
P
A
P
L
RAS
S
-
A
D
-
I
A
R
T
L
K
N
E
N
C
-
V
K
D
V
L
L
A
A
Q
A
A
D
V
A
I
V
G
I
G
A
VSQQ
D
D
A
T
I
---
I
R
S
G
Y
I
S
----
Q
G
E
Q
L
M
I
G
R
K
G
A
V
G
D
I
L
G
Y
F
F
----
D
A
K
G
D
V
V
T
---
N
I
K
I
H
N
E
L
I
G
L
P
L
S
A
L
K
T
I
P
V
R
V
G
V
A
G
G
E
N
K
A
E
A
I
A
A
A
M
K
G
G
Y
-
I
N
A
-
L
V
T
D
Q
D
T
A
A
A
I
L
R
-------
14
PsiBlast_PDB
71.34
27%
-70
- C4 -
3KV1
5
?
A:
[12-261]
------------------------------------------------------------------------------------------------
L
E
Q
K
L
V
E
K
F
N
L
K
R
A
L
I
----
S
L
D
Q
-
P
N
T
N
E
Q
R
K
Q
V
A
A
L
V
S
S
Y
L
N
N
N
L
Q
E
G
M
-
A
V
A
V
-
G
Q
G
Q
N
V
A
A
V
A
D
H
--
A
G
I
V
T
Q
R
N
A
R
F
V
S
A
I
G
G
T
H
------
I
I-
N
--
A
D
H
I
C
R
R
L
A
K
K
Y
G
G
S
S
E
T
L
Y
A
P
A
Y
V
---
N
-
D
P
-
S
L
R
S
A
F
M
E
H
A
T
I
K
E
T
L
S
Q
A
R
K
A
E
F
A
L
V
G
I
G
-----
D
M
D
E
N
---
S
H
M
V
K
L
G
FFT
P
K
E
F
V
E
A
R
L
N
D
G
I
V
G
D
I
G
G
F
D
F
F
K
LD
G
T
D
A
D
T
L
M
---
R
G
R
V
----
I
G
L
E
M
E
D
L
R
Q
I
P
N
V
V
A
M
A
S
E
S
R
K
A
L
S
I
M
G
A
L
R
T
G
V
-
I
D
-
V
L
A
T
S
V
S
C
A
M
A
L
L
N
-------
10
PsiBlast_PDB
70.87
25%
-80
- C4 -
4L4Y
-
LSRR_ECOLI
A:
[18-265]
-------------------------------------------------------------------------------------------
E
G
C
L
E
Y
E
T
Q
L
R
R
Q
F
S
L
Q
H
V
R
V
I
P
G
L
A
--
D
-
V
G
G
R
L
G
I
G
---
A
---
A
H
M
L
M
S
L
L
Q
P
Q
Q
M
L
A
I
G
F
G
E
A
T
M
N
T
L
Q
R
L
--
S
G
F
I
S
S
Q
Q
I
R
L
V
T
L
S
G
G
V
G
S
Y
-
M
-
T
G
I
G
Q
--
L
N
A
A
C
S
-----------
V
N
I
I
P
A
P
L
RAS
S
-
A
D
-
I
A
R
T
L
K
N
E
N
C
-
V
K
D
V
L
L
A
A
Q
A
A
D
V
A
I
V
G
I
G
A
VS-------------
G
Y
I
S
----
Q
G
E
Q
L
M
I
G
R
K
G
A
V
G
D
I
L
G
Y
F
F
----
D
A
K
G
D
V
V
T
---
N
I
K
I
H
N
E
L
I
G
L
P
L
S
A
L
K
T
I
P
V
R
V
G
V
A
G
G
E
N
K
A
E
A
I
A
A
A
M
K
G
G
Y
-
I
N
A
-
L
V
T
D
Q
D
T
A
A
A
I
L
R
-------
28
HHSearch
70.69
21%
-84
- C4 -
3EFB
-
?
A:
[12-266]
--------------------------------------------------------------------------------------------
E
N
L
W
L
E
Q
Q
L
K
Q
K
F
G
L
K
D
V
V
V
V
S
G
N
D
E
D
E
-
E
T
Q
L
A
M
M
G
L
H
G
A
---
Q
L
L
D
R
L
L
E
P
G
-
D
I
V
G
F
-
S
W
G
R
A
V
S
A
L
V
E
N
L
P
Q
A
G
Q
-
S
R
Q
L
I
C
V
P
I
I
G
G
P
S
G
K
L
E
S
R
Y
--
H
--
V
N
T
L
T
Y
S
A
A
A
K
L
K
G
E
S
H
L
A
D
F
P
A
L
L
---
D
-
N
P
L
I
R
N
G
I
M
Q
S
Q
H
-
F
K
T
I
S
A
Y
W
D
N
L
D
I
A
L
V
G
I
G
-----
S
P
---------
A
F
Y
G
----
G
E
E
S
D
D
L
N
A
R
Q
V
A
G
D
I
C
S
R
F
F
----
D
I
H
G
A
M
V
E
T
NM
S
E
K
T
----
L
S
I
E
M
N
K
L
K
Q
A
R
Y
S
I
G
I
A
M
S
E
E
K
Y
S
G
I
I
G
A
L
R
G
-
K
-
Y
I
N
C
L
V
T
N
S
S
T
A
E
L
L
L
K
-------
27
HHSearch
70.19
21%
-81
- C4 -
2GNP
1
?
A:
[9-265]
---------------------------------------------------------------------------------------------
M
F
K
L
E
N
Y
V
K
E
K
Y
S
L
E
S
L
E
I
I
P
N
E
F
D
D
T
P
T
I
L
S
E
R
I
S
Q
V
A
A
---
G
V
L
R
N
L
I
D
D
N
-
M
K
I
G
F
-
S
W
G
K
S
L
S
N
L
V
D
L
I
H
S
K
S
--
V
R
N
V
H
F
Y
P
L
A
G
G
P
S
H
I
-
H
A
K
Y
--
H
--
V
N
T
L
I
Y
E
M
S
R
K
F
H
G
E
C
T
F
M
N
A
T
I
V
Q
---
E
-
N
K
L
L
A
D
G
I
L
Q
S
R
Y
-
F
E
N
L
K
N
S
W
K
D
L
D
I
A
V
V
G
I
G
-----
D
F
S
N
K
GKH
Q
W
L
D
M
L
T
----
E
D
D
F
K
E
L
T
K
V
K
T
V
G
E
I
C
C
R
F
F
----
D
S
K
G
K
E
V
Y
E
N
L
Q
E
R
T
----
I
A
I
S
L
E
D
L
K
N
I
P
Q
S
L
A
V
A
Y
G
D
T
K
V
S
S
I
L
S
V
L
R
A
-
N
-
L
V
N
H
L
I
T
D
K
N
T
I
L
K
V
L
E
E
D
G
D
---
13
PsiBlast_PDB
69.68
25%
-78
- C4 -
4L51
1
LSRR_ECOLI
A:
[18-265]
-------------------------------------------------------------------------------------------
E
G
C
L
E
Y
E
T
Q
L
R
R
Q
F
S
L
Q
H
V
R
V
I
P
G
L
---
D
-
V
G
G
R
L
G
I
G
---
A
---
A
H
M
L
M
S
L
L
Q
P
Q
Q
M
L
A
I
G
F
G
E
A
T
M
N
T
L
Q
R
L
--
S
G
F
I
S
S
Q
Q
I
R
L
V
T
L
S
G
G
V
G
S
Y
-
M
-
T
G
I
G
Q
--
L
N
A
A
C
S
-----------
V
N
I
I
P
A
P
L
RAS
S
-
A
D
-
I
A
R
T
L
K
N
E
N
C
-
V
K
D
V
L
L
A
A
Q
A
A
D
V
A
I
V
G
I
G
A
VSQQ
D
D
A
T
I
---
I
R
S
G
Y
I
S
----
Q
G
E
Q
L
M
I
G
R
K
G
A
V
G
D
I
L
G
Y
F
F
----
D
A
K
G
D
V
V
T
---
N
I
K
I
H
N
E
L
I
G
L
P
L
S
A
L
K
T
I
P
V
R
V
G
V
A
G
G
E
N
K
A
E
A
I
A
A
A
M
K
G
G
Y
-
I
N
A
-
L
V
T
D
Q
D
T
A
A
A
I
L
R
-------