@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0541: (2015-12-01 )
MIVGEQEARALIKPRPKSSHKGDYGSVLLIGGFYPYGGAIIMAALACVKTGAGLVTVATQSCNIPSLHSQLPEVMAFDSDDYKWLEKSIVQSDVIVIGPGLGVSESSRKILNQTMEKIQSHQSVIIDGSALTLLSEGAFPQTKAKNLVLTPHQKEWERLSGIAVSQQTKENTQTALKSFPKGTILVAKSSHTRIFQDLDEKEIIVGGPYQATGGMGDTLCGMIAGMLAQFKEASPLDKVSVGVYLHSAIAQELSKEAYVVLPTTISDEIPKEMARLSK
Atome Classification :
(22 SA)
--------.........10........20........30........40.-.......50........60........70...-.....80...------.....90.---.......100.......110-......-.120.......130.......140.......150..-.....160.......170....-...180.--........190..-.....200.--......210------.........220.......230-.......240.......250....--...260.......270-......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------MIV
G
E
Q
E
A
R
A
L
IKPRPKSSHKGDYG
S
V
L
L
IGGFYPY
G
G
A
I
I
M
-
A
A
L
A
C
V
KTGA
G
L
V
T
V
A
TQSCNI
P
S
L
H
S
QL
P
E
V
-MAFDS
D
D
Y
K
W
------
L
E
K
S
IVQS---
D
V
I
V
IGPGLGV
S
E
S
S
R
K
I
L
N
-
Q
T
M
E
K
I
-
Q
SHQ
S
V
I
IDGS
A
L
T
L
LSEGAFPQTKAK
N
L
V
LTP
H
Q
K
-
E
W
E
R
LS
G
I
A
V
S
Q
QTK
E
N
T
Q
T
A
L
-
K
SFP--K--
G
T
I
L
V
AKSSH
T
R
I
-
F
Q
DLDEK
E
I
--
I
VGGPYQ--------ATGGM
G
D
T
L
C
G
M
I
A
G
M
L
A
Q
F
KE-ASPLD
K
V
S
V
G
V
Y
L
H
S
A
I
A
Q
E
LSKE--
A
Y
V
V
L
PTTI
S
D
E
I
P
K
E
-
M
A
R
LSK
1
PsiBlast_PDB
97.97
53%
-108
- C3 -
3BGK
2
?
A:
[36-304]
---------
I
I
D
D
L
L
T
K
K
I
I
K
P
R
P
L
N
S
H
K
G
T
F
G
R
V
L
L
I
G
G
N
Y
P
Y
G
G
A
I
I
M
-
A
A
L
A
C
V
N
S
G
A
G
L
V
T
V
A
T
H
K
D
N
I
T
A
L
H
S
H
L
P
E
A
-
M
A
F
D
M
V
E
K
D
R
------
L
S
E
Q
I
T
A
A
---
D
V
V
L
M
G
P
G
L
A
E
D
D
L
A
Q
T
T
F
D
-
V
V
W
Q
A
I
-
E
P
K
Q
T
L
I
I
D
G
S
A
I
N
L
L
A
K
R
K
-
A
I
W
P
T
K
Q
I
I
L
T
P
H
Q
K
-
E
W
E
R
L
S
G
L
T
I
P
E
Q
I
E
A
A
T
Q
T
A
L
-
A
H
F
P
--
K
--
E
T
I
L
V
A
K
S
H
Q
T
K
I
-
Y
Q
G
Q
K
I
G
H
I
--
Q
V
G
G
P
Y
Q
--------
A
T
G
G
M
G
D
T
L
A
G
M
I
A
G
F
V
A
Q
F
-
H
-
T
D
R
F
E
V
A
A
A
A
V
F
L
H
S
Y
I
A
D
Q
L
S
K
E
--
A
Y
V
V
L
P
T
R
I
S
A
E
I
T
R
V
-
M
K
E
M
S
E
43
HHSearch
96.75
53%
-106
- C3 -
3BGK
2
?
A:
[36-311]
---------
I
I
D
D
L
L
T
K
K
I
I
K
P
R
P
L
N
S
H
K
G
T
F
G
R
V
L
L
I
G
G
N
Y
P
Y
G
G
A
I
I
M
-
A
A
L
A
C
V
N
S
G
A
G
L
V
T
V
A
T
H
K
D
N
I
T
A
L
H
S
H
L
P
E
A
-
M
A
F
D
M
V
E
K
D
R
------
L
S
E
Q
I
T
A
A
---
D
V
V
L
M
G
P
G
L
A
E
D
D
L
A
-
Q
T
T
F
-
D
V
V
W
Q
A
I
E
P
K
Q
T
L
I
I
D
G
S
A
I
N
L
L
A
K
R
K
-
A
I
W
P
T
K
Q
I
I
L
T
P
H
Q
K
-
E
W
E
R
L
S
G
L
T
I
P
E
Q
I
-
E
A
A
T
Q
T
A
L
A
H
F
P
--
K
--
E
T
I
L
V
A
K
S
H
Q
T
K
I
-
Y
Q
G
Q
K
I
G
H
I
--
Q
V
G
G
P
Y
Q
--------
A
T
G
G
M
G
D
T
L
A
G
M
I
A
G
F
V
A
Q
F
H
T
D
R
--
F
E
V
A
A
A
A
V
F
L
H
S
Y
I
A
D
Q
L
S
K
E
--
A
Y
V
V
L
P
T
R
I
S
A
E
I
T
R
V
-
M
K
E
M
S
E
44
HHSearch
90.11
43%
-101
- C3 -
2R3B
7
NNRD_ENTFA
A:
[25-294]
------------
K
D
I
L
E
E
V
I
T
Q
R
P
S
D
S
Y
K
S
N
F
G
R
V
V
L
I
G
G
N
R
Q
Y
G
G
A
I
I
M
-
S
T
E
A
C
I
N
S
G
A
G
L
T
T
V
I
T
D
V
K
N
H
G
P
L
H
A
R
C
P
E
A
-
M
V
V
G
F
E
E
T
V
L
------
L
T
N
V
V
E
Q
A
---
D
V
I
L
I
G
P
G
L
G
L
D
A
T
A
Q
Q
I
L
K
-
M
V
L
A
Q
H
-
Q
K
Q
Q
W
L
I
I
D
G
S
A
I
T
L
F
S
Q
G
N
F
S
L
T
Y
P
E
K
V
V
F
T
P
H
Q
M
-
E
W
Q
R
L
S
H
L
P
I
E
Q
----
Q
T
L
A
N
N
-
Q
R
Q
Q
A
K
L
--
G
S
T
I
V
L
K
S
H
R
T
T
I
-
F
H
A
G
E
P
F
Q
N
--
T
G
G
N
P
G
M
--------
A
T
G
G
T
G
D
T
L
A
G
I
I
A
G
F
L
A
Q
F
K
P
-
T
--
I
E
T
I
A
G
A
V
Y
L
H
S
L
I
G
D
D
L
A
K
T
--
D
Y
V
V
L
P
T
K
I
S
Q
A
L
P
T
Y
-
M
K
K
Y
A
Q
3
PsiBlast_PDB
89.45
43%
-117
- C3 -
2R3E
2
NNRD_ENTFA
A:
[31-286]
------------------
V
I
T
Q
R
P
S
D
S
Y
K
S
N
F
G
R
V
V
L
I
G
G
N
R
Q
Y
G
G
A
I
I
M
-
S
T
E
A
C
I
N
S
G
A
G
L
T
T
V
I
T
D
V
K
N
H
G
P
L
H
A
R
C
P
E
A
-
M
V
V
G
F
E
E
T
V
L
------
L
T
N
V
V
E
Q
A
---
D
V
I
L
I
G
P
G
L
G
L
D
A
T
A
Q
Q
I
L
K
-
M
V
L
A
Q
H
-
Q
K
Q
Q
W
L
I
I
D
G
S
A
I
T
L
F
S
Q
G
N
F
S
L
T
Y
P
E
K
V
V
F
T
P
H
Q
M
-
E
W
Q
R
L
S
H
L
P
I
E
Q
Q
T
L
A
N
N
Q
R
Q
Q
-
A
K
L
------
G
S
T
I
V
L
K
S
H
R
T
T
I
-
F
H
----------
A
G
E
P
F
Q
N
TGGNPGM
A
T
G
G
T
G
D
T
L
A
G
I
I
A
G
F
L
A
Q
F
K
P
-
T
--
I
E
T
I
A
G
A
V
Y
L
H
S
L
I
G
D
D
L
A
K
T
--
D
Y
V
V
L
P
T
K
I
S
Q
A
L
P
T
Y
-
M
K
K
Y
A
Q
2
PsiBlast_PDB
89.26
43%
-115
- C3 -
2R3B
6
NNRD_ENTFA
A:
[31-286]
------------------
V
I
T
Q
R
P
S
D
S
Y
K
S
N
F
G
R
V
V
L
I
G
G
N
R
Q
Y
G
G
A
I
I
M
-
S
T
E
A
C
I
N
S
G
A
G
L
T
T
V
I
T
D
V
K
N
H
G
P
L
H
A
R
C
P
E
A
-
M
V
V
G
F
E
E
T
V
L
------
L
T
N
V
V
E
Q
A
---
D
V
I
L
I
G
P
G
L
G
L
D
A
T
A
Q
Q
I
L
K
-
M
V
L
A
Q
H
-
Q
K
Q
Q
W
L
I
I
D
G
S
A
I
T
L
F
S
Q
G
N
F
S
L
T
Y
P
E
K
V
V
F
T
P
H
Q
M
-
E
W
Q
R
L
S
H
L
P
I
E
Q
Q
T
L
A
N
N
Q
R
Q
Q
-
A
K
L
------
G
S
T
I
V
L
K
S
H
R
T
T
I
-
F
H
----------
A
G
E
P
F
Q
N
TGGNPGM
A
T
G
G
T
G
D
T
L
A
G
I
I
A
G
F
L
A
Q
F
K
P
-
T
--
I
E
T
I
A
G
A
V
Y
L
H
S
L
I
G
D
D
L
A
K
T
--
D
Y
V
V
L
P
T
K
I
S
Q
A
L
P
T
Y
-
M
K
K
Y
A
Q
33
Fugue
86.36
41%
-93
- C3 -
2R3B
7
NNRD_ENTFA
A:
[13-295]
E
N
L
Y
F
QG
M
R
Y
L
S
K
D
I
L
E
E
V
I
T
Q
R
P
S
D
S
Y
K
S
N
F
G
R
V
V
L
I
G
G
N
R
Q
Y
G
G
A
I
-
I
M
S
T
E
A
C
I
N
S
G
A
G
L
T
T
V
I
T
D
V
K
N
H
G
P
L
H
A
R
C
P
E
A
M
V
V
G
-
F
E
E
T
V
L
------
L
T
N
V
V
E
Q
A
---
D
V
I
L
I
G
P
G
L
G
L
D
A
T
A
Q
Q
I
L
K
M
V
L
A
Q
H
Q
-
K
Q
-
Q
W
L
I
I
D
G
S
A
I
T
L
F
S
Q
G
N
F
S
L
T
Y
P
E
K
V
V
F
T
P
H
-
Q
M
E
W
Q
R
L
S
H
L
P
I
E
Q
Q
T
L
A
N
N
Q
R
Q
Q
-
A
K
L
------
G
S
T
I
V
L
K
S
H
R
T
T
I
-
F
H
A
-
G
E
P
F
Q
--
N
T
G
G
N
P
G
M-------
A
T
G
G
T
G
D
T
L
A
G
I
I
A
G
F
L
A
Q
--
F
-
K
P
T
I
E
T
I
A
G
A
V
Y
L
H
S
L
I
G
D
D
L
A
K
T
--
D
Y
V
V
L
P
T
K
I
S
Q
A
L
P
T
Y
M
K
K
Y
A
Q
P
30
PsiBlast_CBE
82.03
31%
-80
- C3 -
3RQ2
3
NNRD_BACSU
A:
[11-278]
------------
E
E
H
V
R
A
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
-
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
-
T
Y
W
R
D
G
W
K
K
A
------
A
D
A
Q
L
E
E
T
Y--
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
-
H
V
L
----
T
A
D
C
P
V
I
L
D
A
G
A
---
L
A
K
R
T
Y
P
K
R
E
G
P
-
V
I
L
T
P
H
P
G
-
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
-
E
W
A
A
--
Q
L
-
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
--
P
T
G
N
G
A
L
--------
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
---
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
L
W
T
D
E
HS
A
H
T
L
L
A
H
E
L
S
D
I
L
P
R
V
-
W
K
R
F
E
-
31
PsiBlast_CBE
81.36
31%
-79
- C3 -
3RPZ
3
NNRD_BACSU
A:
[11-278]
------------
E
E
H
V
R
A
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
-
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
-
T
Y
W
R
D
G
W
K
K
A
------
A
D
A
Q
L
E
E
T
Y--
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
-
H
V
L
----
T
A
D
C
P
V
I
L
D
A
G
A
---
L
A
K
R
T
Y
P
K
R
E
G
P
-
V
I
L
T
P
H
P
G
-
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
-
E
W
A
A
--
Q
L
-
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
--
P
T
G
N
G
A
L
--------
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
---
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
L
W
T
D
E
HS
A
H
T
L
L
A
H
E
L
S
D
I
L
P
R
V
-
W
K
R
F
E
-
32
PsiBlast_CBE
81.34
31%
-79
- C3 -
3RPH
4
NNRD_BACSU
A:
[11-278]
------------
E
E
H
V
R
A
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
-
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
-
T
Y
W
R
D
G
W
K
K
A
------
A
D
A
Q
L
E
E
T
Y--
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
-
H
V
L
----
T
A
D
C
P
V
I
L
D
A
G
A
---
L
A
K
R
T
Y
P
K
R
E
G
P
-
V
I
L
T
P
H
P
G
-
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
-
E
W
A
A
--
Q
L
-
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
--
P
T
G
N
G
A
L
--------
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
---
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
L
W
T
D
E
HS
A
H
T
L
L
A
H
E
L
S
D
I
L
P
R
V
-
W
K
R
F
E
-
25
PsiBlast_CBE
81.34
31%
-80
- C3 -
3RQQ
2
NNRD_BACSU
A:
[11-278]
------------
E
E
H
V
R
A
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
-
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
-
T
Y
W
R
D
G
W
K
K
A
------
A
D
A
Q
L
E
E
T
Y--
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
-
H
V
L
----
T
A
D
C
P
V
I
L
D
A
G
A
---
L
A
K
R
T
Y
P
K
R
E
G
P
-
V
I
L
T
P
H
P
G
-
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
-
E
W
A
A
--
Q
L
-
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
--
P
T
G
N
G
A
L
--------
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
---
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
L
W
T
D
E
HS
A
H
T
L
L
A
H
E
L
S
D
I
L
P
R
V
-
W
K
R
F
E
-
24
PsiBlast_CBE
81.15
31%
-81
- C3 -
3RQX
5
NNRD_BACSU
A:
[11-278]
------------
E
E
H
V
R
A
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
-
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
-
T
Y
W
R
D
G
W
K
K
A
------
A
D
A
Q
L
E
E
T
Y--
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
-
H
V
L
----
T
A
D
C
P
V
I
L
D
A
G
A
---
L
A
K
R
T
Y
P
K
R
E
G
P
-
V
I
L
T
P
H
P
G
-
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
-
E
W
A
A
--
Q
L
-
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
--
P
T
G
N
G
A
L
--------
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
---
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
L
W
T
D
E
HS
A
H
T
L
L
A
H
E
L
S
D
I
L
P
R
V
-
W
K
R
F
E
-
27
PsiBlast_CBE
80.80
31%
-81
- C3 -
3RQ8
3
NNRD_BACSU
A:
[11-278]
------------
E
E
H
V
R
A
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
-
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
-
T
Y
W
R
D
G
W
K
K
A
------
A
D
A
Q
L
E
E
T
Y--
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
-
H
V
L
----
T
A
D
C
P
V
I
L
D
A
G
A
---
L
A
K
R
T
Y
P
K
R
E
G
P
-
V
I
L
T
P
H
P
G
-
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
-
E
W
A
A
--
Q
L
-
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
--
P
T
G
N
G
A
L
--------
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
---
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
L
W
T
D
E
HS
A
H
T
L
L
A
H
E
L
S
D
I
L
P
R
V
-
W
K
R
F
E
-
28
PsiBlast_CBE
80.77
31%
-79
- C3 -
3RQ6
3
NNRD_BACSU
A:
[11-278]
------------
E
E
H
V
R
A
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
-
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
-
T
Y
W
R
D
G
W
K
K
A
------
A
D
A
Q
L
E
E
T
Y--
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
-
H
V
L
----
T
A
D
C
P
V
I
L
D
A
G
A
---
L
A
K
R
T
Y
P
K
R
E
G
P
-
V
I
L
T
P
H
P
G
-
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
-
E
W
A
A
--
Q
L
-
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
--
P
T
G
N
G
A
L
--------
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
---
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
L
W
T
D
E
HS
A
H
T
L
L
A
H
E
L
S
D
I
L
P
R
V
-
W
K
R
F
E
-
4
PsiBlast_PDB
80.13
33%
-86
- C3 -
3RS8
4
NNR_THEMA
A:
[222-501]
---------
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
-
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
-
I
S
V
P
I
D
T
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
-
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
-
V
L
T
P
H
P
G
-
E
M
A
R
L
V
K
K
T
V
G
-
D
V
K
Y
N
Y
E
L
A
--
E
E
F
A
--
K
E
N
D
C
V
L
V
L
K
S
A
-
T
T
I
-
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
--------
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
-
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
--
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
-
I
R
R
L
K
-
26
PsiBlast_CBE
80.05
31%
-79
- C3 -
3RQH
3
NNRD_BACSU
A:
[11-278]
------------
E
E
H
V
R
A
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
-
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
-
T
Y
W
R
D
G
W
K
K
A
------
A
D
A
Q
L
E
E
T
Y--
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
-
H
V
L
----
T
A
D
C
P
V
I
L
D
A
G
A
---
L
A
K
R
T
Y
P
K
R
E
G
P
-
V
I
L
T
P
H
P
G
-
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
-
E
W
A
A
--
Q
L
-
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
--
P
T
G
N
G
A
L
--------
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
---
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
L
W
T
D
E
HS
A
H
T
L
L
A
H
E
L
S
D
I
L
P
R
V
-
W
K
R
F
E
-
29
PsiBlast_CBE
79.98
31%
-83
- C3 -
3RQ5
3
NNRD_BACSU
A:
[11-278]
------------
E
E
H
V
R
A
T
L
P
E
R
D
------
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
-
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
-
T
Y
W
R
D
G
W
K
K
A
------
A
D
A
Q
L
E
E
T
Y--
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
-
H
V
L
----
T
A
D
C
P
V
I
L
D
A
G
A
---
L
A
K
R
T
Y
P
K
R
E
G
P
-
V
I
L
T
P
H
P
G
-
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
-
E
W
A
A
--
Q
L
-
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
--
P
T
G
N
G
A
L
--------
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
---
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
L
W
T
D
E
HS
A
H
T
L
L
A
H
E
L
S
D
I
L
P
R
V
-
W
K
R
F
E
-
20
PsiBlast_PDB
79.87
33%
-85
- C3 -
3RRJ
-
NNR_THEMA
A:
[222-501]
---------
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
-
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
-
I
S
V
P
I
D
T
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
KDV
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
-
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
-
V
L
T
P
H
P
G
-
E
M
A
R
L
V
K
K
T
V
G
-
D
V
K
Y
N
Y
E
L
A
--
E
E
F
A
--
K
E
N
D
C
V
L
V
L
K
S
A
-
T
T
I
-
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
--------
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
-
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
--
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
-
I
R
R
L
K
-
11
PsiBlast_PDB
79.84
33%
-86
- C3 -
3RTA
1
NNR_THEMA
A:
[222-501]
---------
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
-
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
-
I
S
V
P
I
D
T
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
KDV
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
-
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
-
V
L
T
P
H
P
G
-
E
M
A
R
L
V
K
K
T
V
G
-
D
V
K
Y
N
Y
E
L
A
--
E
E
F
A
--
K
E
N
D
C
V
L
V
L
K
S
A
-
T
T
I
-
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
--------
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
-
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
--
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
-
I
R
R
L
K
-
6
PsiBlast_PDB
79.82
33%
-87
- C3 -
3RSF
-
NNR_THEMA
A:
[222-501]
---------
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
-
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
-
I
S
V
P
I
D
T
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
-
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
-
V
L
T
P
H
P
G
-
E
M
A
R
L
V
K
K
T
V
G
-
D
V
K
Y
N
Y
E
L
A
--
E
E
F
A
--
K
E
N
D
C
V
L
V
L
K
S
A
-
T
T
I
-
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
--------
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
-
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
--
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
-
I
R
R
L
K
-
9
PsiBlast_PDB
79.65
33%
-84
- C3 -
3RT7
3
NNR_THEMA
A:
[222-501]
---------
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
-
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
-
I
S
V
P
I
D
T
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
-
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
-
V
L
T
P
H
P
G
-
E
M
A
R
L
V
K
K
T
V
G
-
D
V
K
Y
N
Y
E
L
A
--
E
E
F
A
--
K
E
N
D
C
V
L
V
L
K
S
A
-
T
T
I
-
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
--------
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
-
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
--
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
-
I
R
R
L
K
-
18
PsiBlast_PDB
79.45
33%
-86
- C3 -
3RRE
2
NNR_THEMA
A:
[222-501]
---------
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
-
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
-
I
S
V
P
I
D
T
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
KDV
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
-
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
-
V
L
T
P
H
P
G
-
E
M
A
R
L
V
K
K
T
V
G
-
D
V
K
Y
N
Y
E
L
A
--
E
E
F
A
--
K
E
N
D
C
V
L
V
L
K
S
A
-
T
T
I
-
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
--------
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
-
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
--
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
-
I
R
R
L
K
-
23
PsiBlast_CBE
79.11
33%
-85
- C3 -
3RSG
3
NNR_THEMA
A:
[222-501]
---------
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
-
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
-
I
S
V
P
I
D
T
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
-
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
-
V
L
T
P
H
P
G
-
E
M
A
R
L
V
K
K
T
V
G
-
D
V
K
Y
N
Y
E
L
A
--
E
E
F
A
--
K
E
N
D
C
V
L
V
L
K
S
A
-
T
T
I
-
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
--------
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
-
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
--
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
-
I
R
R
L
K
-