@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1342: (2015-12-07 )
MYLKSLSIKNYRKYGEEVQTINFAHSKWSEMSGAEDESEKINRTEEYISKSSSLIVGKNNSGKSTIVKLLNTLQNTKSGSRNIFKYTDFNLKMLSDWYRFNIDNKSKEDIESIDKSDFPKLEFQLILGIDDENDLISSFEDILILGGIETVGTHENQEVAEVTIDVKYEVADVQSFLEELVKIKSSPREKIEQYDQGYQKELRYRKFLSLFSSNYFVLNFYPIRRDEPAKEFSLSSLLKVATIEANTVKNDKTLSQAYNKIVSTYIKNNDIVEIDSLVGDINYQVKDMVDTNIKDILQSAVSSIESTKNLKMNLHPDVTLEKIFANSIIYEYQEGNNNIPESQFGMGYTNLMVIIAKIVDYIELYSEKDINGSVNILCIEEPESFMHPQMQELFIKNISKAIATLLGKKQQLDTFQIIITTHSTHILNSKIQSGNTLNNISYLGQVGVNNIIKNVSDDKIASGRDIDKKAYEYIKKYLRLEITDIFFADAVVLVEGVSEETYLRYEIDRHSILKNHHVKVYRIDGAYAHQFISLLDLLGVRTVIFTDLDLKRSESEKKVDIKDNAEPDVIPSNIPDLEEKYGGVASSLTTNGTIQYFVKKLLNDDKAKYDKINSKIIEILTDKEELVVEYNNISMYSQGKINKYYATSFEEAIVLTNAGNEDENKYKKSLIKALQYVHPNMRYFGDIDETSEIADKSYMYQVKLSDGKSKFSTGIVYLSITDKEFSLKRPQYVESGLNLLCGYFEE
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------.........10-----.........20........30........40........50.....----...60........70........80........90........100.......110.......120-........130.......-140.......150.......160.......170.......180.......190--........200.----......210.......220.......230.......240.-......250.......260.......270.......280.......290.......300.......310.......320.......330........340..-......350..-.....360.......370.------......380.........390-.......400.....-..410......-------.420........-430.......440.......450.......460.......470--------.......480...----------....490.......500.......510.......520.......530.......540.......550......-..560..--.....570.......580...-....590.......600--.........610--------........620.......630.......640..-.....650.......660.......670.......680...-....690......-.700.......710...-....720....-...730...-.-...740--....-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------MYLKSL
S
I
K
N
------
Y
R
K
YGEEV
Q
T
I
N
FA
H
S
K
W
SEMSGAE
D
E
S
E
K
I
N
R
T
E
E
Y
I
SKSS
S
L
I
V
----GKNNS
G
K
S
T
I
V
K
L
L
N
T
L
Q
NTKSGSR
N
I
F
K
YTDF
N
L
K
M
L
S
D
W
Y
R
FNIDNK
S
K
E
D
I
E
SIDKSDFP
K
L
--
E
F
Q
L
I
L
G
IDD
E
N
D
L
I
S
S
F
-
E
D
I
L
I
LGG
I
E
TVGTHENQ
E
V
A
E
V
T
I
D
V
K
Y
E
V
A
D
V
Q
S
F
L
E
E
L
V
K
IKSS
P
R
E
K
I
---
E
Q
Y
D
Q
G
Y
Q
K
E
L
R
----
Y
R
K
F
L
S
L
F
SS
N
Y
F
V
L
N
F
Y
PIRRDE
P
A
K
E
F
S
L
S
S
L
L
K
V
A
T
I
-
E
ANTVKN
D
K
T
L
S
Q
A
Y
N
K
I
V
S
T
Y
IKNN
D
I
V
E
I
D
S
L
VGDI
N
Y
Q
V
K
D
M
V
D
T
N
I
K
D
I
L
Q
S
A
V
S
S
I
E
STK
N
L
K
M
NLHPD
V
T
L
E
K
I
F
A
N
S
I
I
Y
-
E
YQEGNNNI
P
E
-
S
Q
-FGM
G
Y
T
N
L
M
V
I
-
I
A
K
I
V
D
Y
I
E
L
Y
SEKDING
S
------
V
N
I
L
C
IE--E
P
E
S
FM
H
P
Q
M
Q
E
-
L
F
I
K
N
I
S
K
A
I
A
T
L
LG-KKQQL
D
T
F
Q
I
I
-------
I
T-THS
T
H
I
LNS-KIQSGNTLN
N
I
S
Y
L
G
QV
G
V
N
N
I
I
K
NVSDDKIASGRDI
D
K
K
A
Y
E
--------
Y
I
K
K
Y
L
R
L
E
I
T
D
I
----------
F
FA
D
A
V
V
L
VEGVSEE
T
Y
L
R
Y
EI
D
R
H
S
I
L
KNH
H
V
K
V
Y
R
I
D
G
A
Y
A
H
Q
F
I
S
L
L
D
L
LGV
R
T
V
I
F
TDLDLK-RSESEK-KVDIKDN--AEPDVIPSNIP
D
L
E
E
K
YGG
V
A
-SSLTTN
G
T
I
Q
Y
F
V
K
K
----
L
LNDDK
A
K
Y
D
K
---------
I
N
S
K
I
I
E
I
LTDKE
E
L
V
V
E
YN
N
I
S
M
YSQGKI
N
K
Y
-
Y
ATSFE
E
A
I
V
L
TNAGNE
D
E
N
K
Y
K
K
S
L
I
K
A
L
Q
Y
VHPN
M
R
Y
FG-DID
E
T
S
E
IADK
S
Y
-
M
Y
Q
V
K
LSDGKSKFST
G
I
-
V
Y
L
S
ITDKEFS-LKR
P
Q
Y
V
E
S
-
G
-
L
N
L
L
C
G--YFEE-----
21
HHSearch
76.54
14%
-36
- C3 -
1E69
-
?
A:
[1069-1145]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Q
K
L
-
S
L
-
L
S
G
G
E
K
A
L
V
G
L
-
A
L
L
F
A
L
M
E
--------
I
K
P
------
S
P
F
Y
V
L
D
--
E
V
D
S
P
L
D
D
Y
N
A
E
-
R
F
K
R
L
L
K
E
N
S
-----------
K
H
T
Q
F
I
-------
V
I
-
T
H
N
K
I
V
M
E
A
A
D
L
L
H
G
V
T
M
V
N
G
V
S
A
I
V
P
V
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
64.61
15%
-17
* C6 *
4BSM
-
XPO1_HUMAN
A:
[3-1017]
A
I
M
T
M
L
A
D
H
A
A
R
Q
L
L
D
F
SQKL
D
I
N
L
L
D
N
V
V
N
C
L
Y
H
G
E
G
A
Q
Q
R
M
A
Q
E
V
L
T
H
L
K
EH
P
D
A
W
T
R
V
D
TQ
N
M
N
T
K
Y
Y
G
L
Q
I
L
E
N
V
I
K
T
RWKILP
R
N
Q
C
E
G
I
K
K
Y
V
V
G
L
I
I
K
T
S
S
DPTC
V
E
K
E
K
V
Y
I
G
K
L
N
M
I
L
V
Q
I
L
K
Q
E
W
P
K
H
W
P
T
F
I
S
D
I
V
G
A
S
R
T
S
---------
E
S
L
C
Q
N
N
M
V
I
L
K
L
L
S
E
E
V
I
T
Q
V
K
S
K
H
L
K
D
S
M
C
N
E
F
S
Q
I
F
Q
L
C
Q
F
V
M
E
N
S
Q
N
A
P
L
V
H
A
T
L
E
T
L
L
R
F
--
L
N
W
I
P
L
G
Y
I
F
E
T
K
L
I
S
T
L
I
Y
K
F
L
N
V
P
M
F
R
N
V
S
L
K
C
L
T
E
I
A
G
V
S
V
S
-
Q
Y
E
E
Q
F
V
T
L
F
T
L
T
M
M
Q
L
K
Q
M
L
P
L
N
T
N
I
R
L
A
Y
S
N
G
K
D
D
E
Q
N
----
F
I
Q
N
L
S
L
F
L
C
T
F
L
K
E
H
D
Q
L
I
E
K
R
L
N
L
R
E
T
L
M
E
A
L
H
Y
M
L
L
V
S
E
V
E
E
T
E
I
F
K
I
C
L
E
Y
W
N
H
L
A
A
E
L
Y
R
E
S
P
F
S
T
S
A
S
P
H
F
D
V
P
-
P
R
R
Q
L
Y
L
P
M
L
F
K
V
R
L
L
M
V
S
--------
R
M
A
K
P
E
E
V
L
V
V
E
N
D
Q
G
E
V
V
R
-
E
F
M
K
D
T
D
S
I
N
L
Y
K
N
-
M
R
E
T
L
V
Y
L
T
H
L
D
Y
V
D
T
E
R
I
M
T
E
K
L
H
N
Q
V
N
G
T
EWS
W
K
N
L
N
T
L
C
W
A
I
G
S
I
S
G
A
M
H
E
E
D
E
K
-
R
F
L
V
T
V
I
K
D
L
L
G
L
C
E
-
Q
K
R
G
K
D
N
K
A
I
I
A
S
N
I
M
Y
I
V
G
-
Q
Y
P
R
F
L
R
A
H
-
W
K
F
L
K
T
V
V
N
K
L
F
E
F
M
H
E
T
H
D
G
V
Q
D
M
A
C
D
T
F
I
K
I
A
Q
K
C
R
R
H
F
V
Q
VQVGEVMP
F
I
D
E
I
L
N
N
I
N
T
I
I
CDLQ
P
Q
Q
V
H
T
F
Y
E
A
V
G
Y
M
I
G
A
Q
T
D
Q
T
V
Q
E
H
L
I
E
K
Y
M
L
L
P
N
Q
V
W
D
S
I
L
K
T
N
V
R
A
C
K
A
V
G
H
P
F
V
I
Q
L
G
R
I
Y
L
D
M
L
N
V
Y
-
K
C
L
S
E
N
I
S
A
A
I
Q
A
N
MV
T
K
Q
P
L
I
R
S
M
R
T
V
K
R
E
T
L
K
L
I
S
-
G
W
V
S
R
S
N
D
P
Q
M
V
A
E
N
F
V
P
P
L
L
D
A
V
L
I
D
Y
Q
R
NVPAAE
V
L
S
T
M
A
I
I
V
N
K
L
H
I
T
A
E
I
P
Q
I
F
D
A
V
F
E
C
T
L
N
M
I
N
K
D
E
Y
P
E
H
R
T
N
F
F
L
L
L
Q
A
V
N
S
H
C
F
P
P
T
Q
F
K
L
V
L
D
S
I
I
W
A
F
K
H
T
M
R
-
N
V
A
D
T
G
L
Q
I
L
F
T
L
-
L
Q
N
V
A
Q
E
E
A
A
A
Q
S
F
Y
Q
T
-
Y
F
C
D
I
L
Q
H
I
F
S
-
V
V
T
N
L
V
E
E
G
-
K
-
L
Q
E
Y
V
A
NP
A
F
K
E
H
L
R
D-
49
Fugue
62.85
17%
-7
* C4 *
4XDN
5
SCC4_YEAST
A:
[24-640]
--------------------------------------------------------------------------------------------------
G
D
K
L
S
I
S
Q
------
V
Y
H
L
A
Q
E
Y
R
--
D
H
A
Y
S
I
A
N
K
I
G
S
E
E
G
L
K
Q
Y
Y
G
L
M
N
M
S
I
Q
M
F
Q
L
L
K
T
KCTL
S
V
L
E
D
S
K
V
T
F
E
M
V
E
L
L
I
Q
E
T
Y
N
-----
F
D
L
A
E
L
Y
I
S
S
L
K
E
R
L
Q
T
H
---
Q
S
D
T
D
L
----
V
E
E
I
M
R
C
--
E
F
L
L
L
------
H
D
L
P
L
M
R
-
D
S
K
F
H
Y
K
I
A
L
R
N
C
N
E
L
V
Q
Y
M
V
N
L
Q
D
E
L
Y
Q
N
W
A
S
V
F
Q
Y
V
G
V
M
L
C
I
K
L
K
Q
H
R
R
V
---
K
T
S
F
H
G
L
L
S
Q
C
R
EKS
Q
W
K
W
F
L
N
L
C
Y
V
N
Y
L
L
N
E
R
F
P
I
---------
P
E
D
A
L
Q
E
L
R
S
T
-
E
L
H
T
V
G
P
E
L
Y
A
W
K
L
A
L
E
M
V
I
Q
L
C
K
D
G
N
I
-------
T
D
H
L
N
E
F
K
N
F
F
D
T
N
K
Q
S
L
V
T
N
------
E
G
K
G
C
V
I
K
I
M
P
R
I
A
L
K
V
--
E
L
P
M
I
F
-
H
Y
K
E
L
K
N
I
L
L
L
-
L
Q
-
S
V
S
Y
I
V
N
----------------------------------
C
Y
D
--
E
K
G
N
F
S
R
K
F
L
P
K
-
V
Y
-
S
T
T
Q
K
L
I
K
N
I
A
A
-
G
G
V
--------------------
S
M
N
E
L
D
S
-
R
I
Q
T
Y
K
S
I
L
E
F
C
E
F
Y
K
V
W
E
Q
T
L
L
K
G
A
V
V
L
G
P
S
P
G
------------------
Y
V
R
L
L
Q
A
M
K
V
Q
F
----------
E
G
G
G
A
V
E
E
Y
T
R
L
A
Q
S
G
G
T
S
S
E
V
K
M
I
S
L
L
N
C
Y
T
V
Q
A
A
R
V
S
R
C
S
G
D
K
---------------------------------------------------------
Q
G
-
E
L
V
E
Q
C
N
K
V
W
L
Q
V
E
K
----
L
L
Q
E
T
D
L
Q
F
N
P
---------
I
W
E
C
T
V
T
I
L
W
L
F
S
H
F
E
-
P
F
S
W
N
P
L
P
C
S
D
K
Q
R
A
E
-
Y
V
S
K
L
R
E
F
Y
S
S
N
K
--
F
V
N
R
F
K
L
K
K
A
L
L
L
Q
I
L
V
N
Y
L
G
G
R
M
L
E
H
D
L
G
E
I
Y
A
I
S
A
K
C
F
D
M
C
R
Q
Q
G
G
M
R
K
V
Q
Y
V
I
G
I
-
W
H
L
M
N
C
T
V
A
M
R
-
G
K
D
V
A
L
T
N
A
-
K
-
L
E
A
L
V
K
--
Q
I
T
S
-----
47
Fugue
51.47
12%
-12
- C7 -
3CE2
6
?
A:
[11-610]
------------------------------------------------------------------------------------------------
Q
V
R
P
R
S
E
I
S
P
------
Q
D
C
W
D
I
T
--------
P
L
Y
L
N
R
K
A
W
K
A
D
L
D
S
F
G
L
K
S
P
T
W
P
A
L
Q
A
T
Q
Y
----
Q
L
D
N
--
S
E
S
L
L
S
L
L
T
T
L
F
S
I
E
R
K
L
N
K
L
Y
V
Y
A
H
L
T
H
D
Q
------------------
D
I
T
N
Q
E
G
I
A
D
--
L
K
S
I
T
H
L
H
T
L
F
A
E
E
T
S
W
V
-
Q
P
A
L
T
S
L
S
E
S
L
I
A
Q
H
L
S
A
P
----------
C
L
A
P
Y
R
F
Y
L
E
K
I
F
R
L
S
I
H
T
G
T
P
G
---
E
E
K
I
L
A
S
A
F
T
P
L
----
E
V
A
S
K
A
F
S
S
L
S
D
S
E
I
P
F
G
Q
A
T
-
D
S
E
G
N
S
H
P
L
S
H
A
L
A
S
L
Y
M
-
Q
S
---
T
D
R
E
L
R
K
T
S
Y
L
A
Q
C
E
R
Y
H
S
Y
------------------------
R
H
T
F
A
N
L
L
N
G
K
I
Q
A
H
V
F
Y
A
K
N
K
R
Y
N
S
C
L
Q
A
A
L
Y
H
-----------
N
N
I
P
T
-
T
V
-
Y
T
N
L
I
D
I
V
K
K
N
-
S
S
L
I
T
K
Y
F
S
I
K
Q
R
C
L
N
L
K
D
------
F
H
F
Y
D
V
Y
--
A
P
L
S
Q
E
K
K
Y
T
F
Q
-
E
A
V
D
L
I
Y
T
S
L
S
P
L
---
G
T
E
Y
I
D
T
L
K
Q
G
-------
L
T
---
T
Q
G
W
V
D
K
-
Y
E
N
L
N
K
R
S
G
A
Y
S
S
G
C
Y
D
S
H
P
Y
V
L
L
N
Y
T
G
T
-
L
Y
D
V
S
V
I
A
H
E
G
G
H
--------
S
M
H
S
Y
F
S
R
K
H
Q
P
F
----------
H
D
A
Q
Y
P
I
F
L
A
E
I
A
S
T
L
N
E
M
L
L
M
D
S
M
L
K
E
S
D
S
K
E
E
K
I
T
I
L
T
R
C
L
D
T
I
F
S
T
L
----
F
R
Q
V
L
F
A
S
F
E
Y
D
-
I
H
H
A
A
E
-
H
---
G
V
P
--
L
T
E
E
Y
L
S
S
T
Y
K
N
L
Q
N
E
F
Y
G
------------------------------------------------
E
I
I
T
F
D
V
L
S
N
I
E
W
A
R
I
P
H
F
Y
Y
N
F
Y
V
Y
Q
-
Y
A
T
G
I
I
A
A
L
C
F
L
E
K
I
L
N
N
E
D
N
A
L
N
S
Y
L
N
F
L
K
--------------------------------
S
G
G
S
D
F
P
L
E
I
-
L
K
K
S
G
L
D
-----
M
G
T
V
E
P
I
Q
K
-
A
-
F
C
F
I
E
K
--
K
I
Q
E
L
S
S
L
I
44
Fugue
41.49
12%
18
* C7 *
2QR4
-
?
A:
[25-602]
--------------------------------------------------------------------------------------------------------
L
S
------
D
Q
E
F
D
E
K
Y
L
E
L
S
E
E
L
K
Q
S
E
K
H
K
G
----------------------------
T
L
D
Q
G
A
S
Q
F
L
N
A
I
E
F
V
L
R
V
Y
R
Q
T
E
V
I
Y
V
Y
A
H
L
K
N
D
Q
---------
D
T
G
N
T
D
Y
Q
A
L
Y
A
R
A
S
S
L
F
S
--
K
V
S
E
A
V
S
W
-----
F
E
P
E
I
-
L
Q
L
-------------
S
D
D
Q
I
W
Q
Y
F
K
E
E
P
K
L
E
V
Y
R
H
Y
I
Q
Q
I
V
D
N
R
A
H
V
L
S
A
E
---
Q
E
S
L
L
A
G
A
G
E
I
F
----
D
A
S
S
D
T
F
A
V
L
N
N
A
D
L
V
F
-
P
T
I
E
G
E
N
G
E
I
V
Q
L
S
H
G
V
Y
G
Q
L
L
-
E
S
---
T
D
R
R
V
R
E
A
A
F
K
G
L
Y
S
V
Y
E
Q
F
R
N
T
F
A
-
S
T
L
G
T
H
I
K
G
H
N
F
K
A
K
V
R
N
Y
S
S
A
R
E
A
S
L
S
N
N
H
I
P
E
S
V
Y
D
T
L
V
D
V
V
N
K
H
--
L
P
L
L
H
R
Y
M
E
L
R
K
R
L
L
E
V
E
K
-
L
H
M
Y
-------------------------
D
L
Y
T
P
------
V
L
G
E
A
P
I
--
E
A
K
E
K
A
L
E
A
L
K
P
M
G
-----------
E
E
Y
M
A
I
T
L
D
Q
L
F
T
L
V
-------
H
E
M
G
H
S
V
H
S
Y
F
T
-
I
----------------------------------------------------------------------------
F
L
A
E
I
A
S
T
T
N
E
N
I
L
T
E
Y
L
L
E
T
E
---
K
D
P
R
V
R
A
Y
V
L
N
H
Y
L
D
G
F
K
G
T
V
-----
F
R
Q
T
Q
F
A
E
F
E
H
F
M
H
T
E
D
E
K
-
G
V
P
L
------
T
S
E
Y
L
S
D
S
Y
G
K
L
N
A
K
Y
Y
G
------------------------------------------------
P
A
V
E
E
D
P
E
I
K
F
E
W
S
R
I
P
H
F
Y
Y
N
Y
Y
V
F
Q
-
Y
S
T
G
F
S
A
A
S
A
L
A
K
K
I
L
N
Q
E
P
E
A
L
E
N
Y
L
A
Y
L
K
A
--------------------------------
G
N
S
D
Y
P
V
E
V
M
K
K
A
G
V
-----
D
M
T
Q
A
A
Y
I
E
D
A
M
S
M
F
E
Q
R
L
N
--
E
L
E
E
L
I
D
R
E
24
HHSearch
40.93
15%
-21
- C3 -
3QF7
2
RAD50_THEMA
A:
[273-350]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
R
P
A
-
R
G
-
L
S
G
G
E
R
A
L
I
S
I
-
S
L
A
M
S
L
A
E
V
A
------
S
G
R
------
L
D
A
F
F
I
D
--
E
G
F
S
S
L
D
T
E
N
K
E
-
K
I
A
S
V
L
K
E
L
E
R
----------
L
N
K
V
I
V
-------
F
I
-
T
H
D
R
E
F
S
E
A
-
F
D
R
K
L
R
I
T
G
G
V
V
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
40.66
12%
-4
- C6 -
1G6H
3
LIVG_METJA
A:
[4-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
E
I
L
R
T
E
N
I
V
K
Y
FG---
E
F
K
A
L
D
-
G
V
S
I
S
V
N
K
-
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
----------------------------
E
G
R
V
Y
F
E
N
--------
K
D
I
T
N
K
---------------------------
E
P
A
E
L
Y
-
H
Y
G
-
I
V
R
T
F
Q
T
P
Q
P
L
K
E
M
--
T
V
L
E
N
L
L
I
G
E
I
C
P
G
E
S
P
L
N
S
L
F
Y
K
K
W
I
P
K
E
E
E
M
V
E
K
A
F
K
I
L
E
F
L
K
L
-
S
H
L
Y
D
------------------------
R
K
A
-
G
E
-
L
S
G
G
Q
M
K
L
V
E
I
-
G
R
A
L
M
T
------
N
------------
P
K
M
I
V
M
D
--
E
P
I
A
G
V
A
---------
P
G
L
A
H
D
I
F
N
H
V
L
-
E
L
K
A
K
-
G
I
T
F
L
-------
I
I
-
E
H
R
L
D
I
V
L
N
-
Y
I
------
D
H
L
Y
V
M
F
--
N
G
Q
I
I
A
E
G
R
G
E
E
E
I
K
N
V
L
S
D
P
K
V
V
E
I
--------
Y
I
G
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
40.19
29%
13
- C5 -
2O5V
1
RECF_DEIRA
A:
[4-52]
------------------------------------------------------------------------------------------------
V
R
L
S
A
L
S
T
L
N
------
Y
R
N
L
A
P
G
--
T
L
N
F
P
-------------------------
E
G
V
T
G
I
Y
----
G
E
N
G
A
G
K
T
N
L
L
E
A
A
Y
L
A
L
T
G
Q
T
D
A
P
R
I
E
Q
L
I
Q
A
G
E
T
E
A
Y
V
R
A
D
L
Q
Q
G
G
S
L
S
I
Q
E
V
G
L
G
R
G
R
R
Q
L
K
--
V
D
G
V
R
A
R
T
G
D
L
P
R
G
G
A
V
W
-
I
R
P
E
D
S
E
L
V
F
G
P
P
S
G
R
R
A
Y
L
D
S
L
L
S
R
L
S
A
R
Y
G
E
Q
L
S
R
Y
E
R
T
V
S
Q
R
N
A
A
L
R
G
G
---
E
E
W
A
M
H
V
W
D
D
V
L
----
L
K
L
G
T
E
I
M
L
F
R
R
R
A
L
T
R
L
D
E
L
A
R
E
A
N
A
Q
L
G
S
R
K
T
L
A
L
T
L
T
-
E
S
T
S
P
E
T
Y
A
A
D
L
R
G
R
R
A
E
E
L
A
R
G
S
T
V
T
G
P
H
R
D
D
L
L
L
T
L
G
D
F
P
A
S
D
Y
A
S
R
G
E
G
R
T
V
A
L
A
L
R
R
A
E
L
E
L
L
R
E
K
F
G
E
D
P
V
L
L
L
D
D
F
T
A
E
L
D
-
P
H
R
R
Q
Y
L
L
D
L
A
-
A
S
-
V
P
Q
A
I
V
T
G
T
E
L
-
A
P
G
A
A
L
T
L
R
A
Q
A
G
R
F
T
P
V
A
------
D
E
E
M
Q
A
E
--
G
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
39.94
14%
-27
- C3 -
3QKT
2
A:
[241-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
E
R
P
L
-
T
F
-
L
S
G
G
E
R
I
A
L
G
L
-
A
F
R
L
A
M
S
L
Y
L
------
A
G
E
------
I
S
L
L
I
L
D
--
E
P
T
P
Y
L
D
E
E
R
R
R
-
K
L
I
T
I
M
E
R
Y
L
K
----------
K
I
P
Q
V
I
-------
L
V
-
S
H
D
E
E
L
K
D
A
-
A
D
H
V
I
R
I
S
L
E
N
G
S
S
K
V
E
V
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
39.65
10%
-35
- C3 -
3TUI
-
METN_ECOLI
C:
[163-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
L
S
G
G
Q
K
Q
R
V
A
I
-
A
R
A
L
A
S
------------
N
------
P
K
V
L
L
C
D
--
Q
A
T
S
A
L
D
P
A
T
T
R
-
S
I
L
E
L
L
K
D
I
N
R
R
---------
L
G
L
T
I
L
-------
L
I
-
T
H
E
M
D
V
V
K
R
-
I
------
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
--------
T
L
H
L
D
I
P
E
D
Y
Q
E
R
----------
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
-
T
Q
A
A
I
A
-
W
L
Q
E
H
H
V
--
K
V
E
V
L
G
Y
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
39.59
7%
-24
- C3 -
1W1W
2
SMC1_YEAST
A:
[328-402]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
D
M
-
E
Y
-
L
S
G
G
E
K
T
V
A
A
L
-
A
L
L
F
A
I
N
--
S
------
Y
Q
P
------
S
P
F
F
V
L
D
--
E
V
D
A
A
L
D
I
T
N
V
Q
-
R
I
A
A
Y
I
R
R
H
R
N
----------
P
D
L
Q
F
I
-------
V
I
-
S
L
K
N
T
M
F
E
K
-
S
D
A
L
V
G
V
Y
R
Q
Q
Q
E
N
S
S
K
I
I
T
L
D
L
S
N
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
38.58
12%
-26
- C3 -
3FVQ
1
FBPC_NEIG1
A:
[138-215]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
L
S
G
G
Q
Q
Q
R
A
A
L
-
A
R
A
L
A
P
------------
D
------
P
E
L
I
L
L
D
--
E
P
F
S
A
L
D
E
Q
L
R
R
-
Q
I
R
E
D
M
I
A
A
L
R
A
---------
N
G
K
S
A
V
-------
F
V
-
S
H
D
R
E
E
A
L
Q
-
Y
------
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
E
--------
G
I
V
F
P
A
A
L
N
A
D
G
T
----------
A
D
C
R
L
G
R
L
P
V
Q
S
G
A
P
A
G
T
R
G
T
L
L
I
R
P
E
Q
Y
S
L
H
P
H
S
A
P
A
A
S
I
H
A
V
V
L
K
T
T
P
K
A
R
H
T
E
I
S
L
R
A
G
Q
T
V
L
-
T
L
N
L
L
S
-
D
G
I
S
A
V
L
--
H
L
D
G
P
A
L
F
F
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
38.18
15%
-14
- C3 -
3AUY
1
RAD50_METJA
A:
[273-351]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
V
L
T
I
-
D
N
-
L
S
G
G
E
Q
I
A
V
A
L
-
S
L
R
L
A
I
A
N
A
L
I
-----
G
N
R
------
V
E
C
I
I
L
D
--
E
P
T
V
Y
L
D
E
N
R
R
A
-
K
L
A
E
I
F
R
K
V
K
-----------
S
I
P
Q
M
I
-------
I
I
-
T
H
H
R
E
L
E
D
V
-
A
D
V
I
I
N
V
K
K
D
G
N
V
S
K
V
K
I
N
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
37.76
11%
-27
- C3 -
3B60
2
MSBA_SALTY
A:
[480-553]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
L
S
G
G
Q
R
Q
R
I
A
I
-
A
R
A
L
L
R
------------
D
------
S
P
I
L
I
L
D
--
E
A
T
S
A
L
D
T
E
S
E
R
-
A
I
Q
A
A
L
D
E
L
Q
-----------
K
N
R
T
S
L
-------
V
I
-
A
H
R
L
S
T
I
E
Q
--------
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
--------
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
37.54
15%
-4
- C2 -
1A8R
1
GCH1_ECOLI
A:
[1-221]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
L
S
K
E
A
A
L
V
H
E
A
L
V
A
R
G
L
E
T
P
L
R
P
-
P
V
H
E
M
D
N
E
T
R
K
S
L
I
A
G
H
M
T
E
I
M
Q
L
L
N
L
D
L
A
D
D
S
L
M
E
T
P
H
R
I
A
K
M
Y
V
D
E
I
F
S
G
L
D
Y
A
N
F
P
K
I
T
L
I
E
N
-
K
M
K
V
D
E
M
V
T
V
R
D
I
T
L
T
S
T
C
E
-
S
H
--
F
V
T
I
D
G
K
-
A
T
-
V
A
Y
I
P
K
D
S
V
I
G
-
L
S
K
I
N
R
I
V
Q
F
F
A
Q
R
---------------------------
P
Q
V
Q
E
-
R
L
T
Q
Q
I
L
I
A
L
Q
T
L
L
G
-
T
N
---
N
V
A
V
S
I
-------
D
A
-
V
H
Y
C
V
K
A
R
G
-
I
R
D
A
T
S
A
T
T
T
T
S
L
G
G
L
F
K
S
S
Q
N
T
R
H
E
F
L
R
A
V
R
H
H
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
37.33
17%
-15
- C3 -
3RLF
3
MALK_ECOLI
A:
[133-210]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
L
S
G
G
Q
R
Q
R
V
A
I
-
G
R
T
L
V
A
------------
E
------
P
S
V
F
L
L
D
--
E
P
L
S
N
L
D
A
A
L
R
V
-
Q
M
R
I
E
I
S
R
L
H
K
R
---------
L
G
R
T
M
I
-------
Y
V
-
T
H
D
Q
V
E
A
M
T
-
L
------
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
--------
P
K
M
N
F
L
P
V
K
V
T
A
T
----------
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
-
I
H
I
Q
I
P
-
S
I
R
Q
N
L
V
--
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
-
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
----
L
H
K
E
P
G
V
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
37.12
14%
-2
- C3 -
1KAG
-
AROK_ECOLI
A:
[3-171]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
R
N
I
F
L
V
G
P
M
G
A
G
---------
K
S
T
I
G
R
Q
L
A
Q
Q
L
-
N
--------
M
E
F
Y
D
S
D
Q
E
I
E
K
R
----------
T
G
A
D
V
G
W
V
F
D
L
E
G
E
E
G
F
R
D
R
E
E
K
V
I
N
E
L
T
E
K
Q
G
I
V
L
A
T
G
G
G
S
V
K
S
R
E
T
R
N
R
L
S
A
R
G
V
V
V
Y
L
E
T
T
I
E
-
K
Q
L
A
R
T
-
P
L
L
H
V
E
T
--
P
P
R
E
V
L
E
A
L
A
N
E
R
N
P
L
Y
E
E
I
A
D
V
T
I
----
S
A
K
V
V
A
N
Q
----
I
I
H
M
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
37.03
18%
-23
- C3 -
1V43
-
?
A:
[142-219]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
L
S
G
G
Q
R
Q
R
V
A
V
-
A
R
A
I
V
V
------------
E
------
P
D
V
L
L
M
D
--
E
P
L
S
N
L
D
A
K
L
R
V
-
A
M
R
A
E
I
K
K
L
Q
Q
K
---------
L
K
V
T
T
I
-------
Y
V
-
T
H
D
Q
V
E
A
M
T
-
M
------
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
--------
P
E
M
N
I
L
E
V
S
V
G
D
G
----------
Y
L
E
G
R
G
F
R
I
E
L
P
Q
M
D
L
L
K
D
Y
V
G
K
T
V
L
F
G
I
R
P
E
H
M
T
V
E
G
V
H
M
K
R
T
A
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
-
F
G
D
E
L
V
-
K
V
K
L
P
G
H
--
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
-
D
K
D
T
E
K
A
I
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
36.60
16%
-25
- C3 -
3ZDQ
-
ABCBA_HUMAN
A:
[483-556]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
L
S
G
G
Q
K
Q
R
I
A
I
-
A
R
A
L
L
K
------------
N
------
P
K
I
L
L
L
D
--
E
A
T
S
A
L
D
A
E
N
E
Y
-
L
V
Q
E
A
L
D
R
L
M
-----------
D
G
R
T
V
L
-------
V
I
-
A
H
R
L
S
T
I
K
N
--------
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
35.88
10%
-24
* C3 *
1OXX
8
?
K:
[139-217]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
-
L
S
G
A
Q
Q
Q
R
V
A
L
-
A
R
A
L
V
K
------------
D
------
P
S
L
L
L
L
D
--
E
P
F
S
N
L
D
A
R
M
R
D
-
S
A
R
A
L
V
K
E
V
Q
S
R
---------
L
G
V
T
L
L
-------
V
V
-
S
H
D
P
A
D
I
F
A
-
I
------
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
--------
I
N
E
L
E
G
K
V
T
N
E
G
V
----------
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
-
E
I
F
T
Y
S
-
D
H
P
I
H
S
G
--
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------