@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1825: (2015-12-11 )
MIKIFDTHTHLNVENFEGKIDEEINLASELGVTKMNVVGFDQDTISKSLELSSQYAQVYSTIGWHPTEAGSYDDNIESMIISHLENPKVIALGEIGLDYYWMEDPKDIQIEVFKRQIELSKEYNLPFVVHTRDALEDTYEVIKESGVGPFGGIMHSFSGSLEMAQKFIDLGMMISFSGVVTFKKALDVQEAARELPLDKILVETDAPYLAPVPKRGRENKTAYTRYVVEKIAELRGITVEEVAEATYQNAVRIFRLDEKN
Atome Classification :
(20 SA)
.........10.---....---.----------..20........30........40.....----...50....----.----.----..60.....-...70.---.----.-------------------.....80....------.------.-..90........----100-.-.----..-...110.......120.----......130.......140.....------------------------..150........160.......-170........-.180.-.-.....190.......200......-----.210-------------.---..-.----------------------------------------.-----.----.-------..220.......230.......240.......250.......260
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
K
I
FDTHT
H
L
N
---VENF---E----------GKI
D
E
E
I
N
L
A
S
ELG
V
T
K
M
N
V
V
GF
D
Q
D
T
I
S
----
K
S
L
E
L
S
S
Q
Y
----
A
----
Q
----
V
Y
S
TIGWHP-TEAGSY---D----D-------------------
N
I
E
S
M
I
I
S
HLE------N------
P
-
K
V
I
A
L
G
EIG
L
D
Y
----
Y
WM-E-D----PK-
D
I
Q
I
E
V
F
K
R
Q
I
E
LSKEY----NL
P
F
V
V
H
T
R
D
A
L
E
D
T
Y
E
V
I
K
ESGV------------------------G
P
F
G
-
G
I
M
H
SFSG
S
L
E
M
A
Q
K
F
I
D
-L--G
M
M
I
S
FS
G
-
V
V
T
F
K
-
K
-AL
D
V
Q
E
A
A
R
ELPL
D
K
I
L
VETDAPY-----LA---------------P---VP-K----------------------------------------R-----G----R-------EN
K
T
A
Y
T
R
Y
V
V
E
K
I
A
E
L
RGI
T
V
E
E
V
A
E
A
T
Y
Q
N
A
V
R
I
F
R
LDEKN
28
HHSearch
93.29
44%
-90
- C1 -
2GZX
2
?
A:
[2-254]
---
L
I
D
T
H
V
H
L
N
---
D
E
Q
Y
---
D
----------
D
D
L
S
E
V
I
T
R
A
R
E
A
G
V
D
R
M
F
V
V
G
F
N
K
S
T
I
E
----
R
A
M
K
L
I
D
E
Y
----
D
----
F
----
L
Y
G
I
I
G
W
H
P
-
V
D
A
I
D
F
---
T
----
E
-------------------
E
H
L
E
W
I
E
S
L
A
Q
------
H
------
P
-
K
V
I
G
I
G
E
M
G
L
D
Y
----
H
W
D
-
K
-
S
----
P
A
-
D
V
Q
K
E
V
F
R
K
Q
I
A
L
A
K
R
L
----
K
L
P
I
I
I
H
N
R
E
A
T
Q
D
C
I
D
I
L
L
E
E
H
A
------------------------
E
E
V
G
-
G
I
M
H
S
F
S
G
S
P
E
I
A
D
I
V
T
N
-
K
L-
N
F
Y
I
S
L
G
G
-
P
V
T
F
K
-
N
-
A
K
Q
P
K
E
V
A
K
H
V
S
M
E
R
L
L
V
E
T
D
A
P
Y
-----
L
S
---------------
P
---
H
P
-
Y
----------------------------------------
R
-----
G
----
K
-------
R
N
E
P
A
R
V
T
L
V
A
E
Q
I
A
E
L
K
G
L
S
Y
E
E
V
C
E
Q
T
T
K
N
A
E
K
L
F
N
-----
1
PsiBlast_PDB
93.06
43%
-92
- C1 -
2GZX
2
?
A:
[2-254]
---
L
I
D
T
H
V
H
L
N
---
D
E
Q
Y
---
D
----------
D
D
L
S
E
V
I
T
R
A
R
E
A
G
V
D
R
M
F
V
V
G
F
N
K
S
T
I
E
----
R
A
M
K
L
I
D
E
Y
----
D
----
F
----
L
Y
G
I
I
G
W
H
P
-
V
D
A
I
D
F
---
T
----
E
-------------------
E
H
L
E
W
I
E
S
L
A
Q
------
H
------
P
-
K
V
I
G
I
G
E
M
G
L
D
Y
----
H
W
D
-
K
-
S
----
P
A
-
D
V
Q
K
E
V
F
R
K
Q
I
A
L
A
K
R
L
----
K
L
P
I
I
I
H
N
R
E
A
T
Q
D
C
I
D
I
L
L
E
E
H
A
------------------------
E
E
V
G
-
G
I
M
H
S
F
S
G
S
P
E
I
A
D
I
V
T
N
K
L
--
N
F
Y
I
S
L
G
G
-
P
V
T
F
K
-
N
-
A
K
Q
P
K
E
V
A
K
H
V
S
M
E
R
L
L
V
E
T
D
A
P
Y
-----
L
S
---------------
P
---
H
P
-
Y
----------------------------------------
R
-----
G
----
K
-------
R
N
E
P
A
R
V
T
L
V
A
E
Q
I
A
E
L
K
G
L
S
Y
E
E
V
C
E
Q
T
T
K
N
A
E
K
L
F
N
-----
3
PsiBlast_PDB
84.85
37%
-86
- C1 -
1J6O
-
?
A:
[2-250]
-----
D
T
H
A
H
L
H
---
F
H
Q
F
---
D
----------
D
D
R
N
A
V
I
S
S
F
E
E
N
N
I
E
F
V
V
N
V
G
V
N
L
E
D
S
K
----
K
S
L
D
L
S
K
T
S
----
D
----
R
----
I
F
C
S
V
G
V
H
P
-
H
D
A
K
E
V
---
P
----
E
-------------------
D
F
----
I
E
H
L
E
K
F
A
K--
D
------
E
-
K
V
V
A
I
G
E
T
G
L
D
F
----
F
R
N
-
I
-
S
----
P
A
-
E
V
Q
K
R
V
F
V
E
Q
I
E
L
A
G
K
L
----
N
L
P
L
V
V
H
I
R
D
A
Y
S
E
A
Y
E
I
L
R
T
E
S
L
------------------------
P
E
K
R
-
G
V
I
H
A
F
S
S
D
Y
E
W
A
K
K
F
I
D
-
L
--
G
F
L
L
G
I
G
G
-
P
V
T
Y
P
-
K
-
N
E
A
L
R
E
V
V
K
R
V
G
L
E
Y
I
V
L
E
T
D
C
P
F
-----
L
P
---------------
P
---
Q
P
-
F
----------------------------------------
R
-----
G
----
K
-------
R
N
E
P
K
Y
L
K
Y
V
V
E
T
I
S
Q
V
L
G
V
P
E
A
K
V
D
E
A
T
T
E
N
A
R
R
I
F
L
E
V
K
E
-
30
HHSearch
84.06
38%
-80
- C1 -
1YIX
2
YCFH_ECOLI
A:
[1-259]
-
M
F
L
V
D
S
H
C
H
L
D
---
G
L
D
Y
ESL
H
----------
K
D
V
D
D
V
L
A
K
A
A
A
R
D
V
K
F
C
L
A
V
A
T
T
L
P
S
Y
L
----
H
M
R
D
L
V
G
E
R
----
D
----
N
----
V
V
F
S
C
G
V
H
P
-
L
N
Q
N
D
P
----------------------------
Y
D
V
E
D
L
R
R
L
A
A
------
E
------
E
-
G
V
V
A
L
G
E
T
G
L
D
Y
----
Y
Y
T
-
P
-
E
----
T
K
-
V
R
Q
Q
E
S
F
I
H
H
I
Q
I
G
R
E
L
----
N
K
P
V
I
V
H
T
R
D
A
R
A
D
T
L
A
I
L
R
E
E
K
V
------------------------
T
D
C
G
-
G
V
L
H
C
F
T
E
D
R
E
T
A
G
K
L
L
D
-
L
--
G
F
Y
I
S
F
S
G
-
I
V
T
F
R
-
N
-
A
E
Q
L
R
D
A
A
R
Y
V
P
L
D
R
L
L
V
E
T
D
S
P
Y
-----
L
A
---------------
P
---
V
P
-
H
----------------------------------------
R
-----
G
----
K
-------
E
N
Q
P
A
M
V
R
D
V
A
E
Y
M
A
V
L
K
G
V
A
V
E
E
L
A
Q
V
T
T
D
N
F
A
R
L
F
H
I
D
A
S
R
2
PsiBlast_PDB
84.04
39%
-84
- C1 -
1YIX
2
YCFH_ECOLI
A:
[3-257]
---
L
V
D
S
H
C
H
L
D
GLD
Y
E
S
L
---
H
----------
K
D
V
D
D
V
L
A
K
A
A
A
R
D
V
K
F
C
L
A
V
A
T
T
L
P
S
Y
L
----
H
M
R
D
L
V
G
E
R
----
D
----
N
----
V
V
F
S
C
G
V
H
P
L
N
Q
N
D
P
Y
---
D
-------------------------
V
E
D
L
R
R
L
A
A
E
------
E
--------
G
V
V
A
L
G
E
T
G
L
D
Y
----
Y
Y
T
-
P
-
E
----
T
K
-
V
R
Q
Q
E
S
F
I
H
H
I
Q
I
G
R
E
L
----
N
K
P
V
I
V
H
T
R
D
A
R
A
D
T
L
A
I
L
R
E
E
K
V
------------------------
T
D
C
G
-
G
V
L
H
C
F
T
E
D
R
E
T
A
G
K
L
L
D
-
L
--
G
F
Y
I
S
F
S
G
-
I
V
T
F
R
-
N
-
A
E
Q
L
R
D
A
A
R
Y
V
P
L
D
R
L
L
V
E
T
D
S
P
Y
-----
L
A
---------------
P
---
V
P
-
H
----------------------------------------
R
-----
G
----
K
-------
E
N
Q
P
A
M
V
R
D
V
A
E
Y
M
A
V
L
K
G
V
A
V
E
E
L
A
Q
V
T
T
D
N
F
A
R
L
F
H
I
D
A
S
R
21
PsiBlast_CBE
83.98
39%
-84
- C1 -
1YIX
2
YCFH_ECOLI
B:
[3-257]
---
L
V
D
S
H
C
H
L
D
GLD
Y
E
S
L
---
H
----------
K
D
V
D
D
V
L
A
K
A
A
A
R
D
V
K
F
C
L
A
V
A
T
T
L
P
S
Y
L
----
H
M
R
D
L
V
G
E
R
----
D
----
N
----
V
V
F
S
C
G
V
H
P
L
N
Q
N
D
P
Y
---
D
-------------------------
V
E
D
L
R
R
L
A
A
E
------
E
--------
G
V
V
A
L
G
E
T
G
L
D
Y
----
Y
Y
T
-
P
-
E
----
T
K
-
V
R
Q
Q
E
S
F
I
H
H
I
Q
I
G
R
E
L
----
N
K
P
V
I
V
H
T
R
D
A
R
A
D
T
L
A
I
L
R
E
E
K
V
------------------------
T
D
C
G
-
G
V
L
H
C
F
T
E
D
R
E
T
A
G
K
L
L
D
-
L
--
G
F
Y
I
S
F
S
G
-
I
V
T
F
R
-
N
-
A
E
Q
L
R
D
A
A
R
Y
V
P
L
D
R
L
L
V
E
T
D
S
P
Y
-----
L
A
---------------
P
---
V
P
-
H
----------------------------------------
R
-----
G
----
K
-------
E
N
Q
P
A
M
V
R
D
V
A
E
Y
M
A
V
L
K
G
V
A
V
E
E
L
A
Q
V
T
T
D
N
F
A
R
L
F
H
I
D
A
S
R
25
HHSearch
82.28
30%
-84
- C1 -
1ZZM
4
YJJV_ECOLI
A:
[2-259]
I
C
R
F
I
D
T
H
C
H
F
D
---
F
P
P
F
---
S
----------
G
D
E
E
A
S
L
Q
R
A
A
Q
A
G
V
G
K
I
I
V
P
A
T
E
A
E
N
F
A
----
R
V
L
A
L
A
E
N
Y
----
Q
----
P
----
L
Y
A
A
L
G
L
H
P
-
G
M
L
E
K
H
---
S
----
D
-------------------
V
S
L
E
Q
L
Q
Q
A
L
E
------
R
RP----
A
-
K
V
V
A
V
G
E
I
G
L
D
L
----
F
G
D
-
D
-
P
----
Q
F
-
E
R
Q
Q
W
L
L
D
E
Q
L
K
L
A
K
R
Y
----
D
L
P
V
I
L
H
S
R
R
T
H
D
K
L
A
M
H
L
K
R
H
D
L
-------------------------
P
R
T
-
G
V
V
H
G
F
S
G
S
L
Q
Q
A
E
R
F
V
Q
-
L
--
G
Y
K
I
G
V
G
G
-
T
I
T
Y
P
-
R
-
A
S
K
T
R
D
V
I
A
K
L
P
L
A
S
L
L
L
E
T
D
A
P
D
-----
M
P
---------------
L
---
N
G
-
F
----------------------------------------
Q
-----
G
----
Q
-------
P
N
R
P
E
Q
A
A
R
V
F
A
V
L
C
E
L
R
R
E
P
A
D
E
I
A
Q
A
L
L
N
N
T
Y
T
L
F
N
V
P
---
4
PsiBlast_PDB
81.77
30%
-82
- C1 -
1ZZM
4
YJJV_ECOLI
A:
[2-256]
I
C
R
F
I
D
T
H
C
H
F
D
---
F
P
P
F
---
S
----------
G
D
E
E
A
S
L
Q
R
A
A
Q
A
G
V
G
K
I
I
V
P
A
T
E
A
E
N
F
A
----
R
V
L
A
L
A
E
N
Y
----
Q
----
P
----
L
Y
A
A
L
G
L
H
P
-
G
M
L
E
K
H
---
S
----
D
V
------------------
S
L
E
Q
L
Q
Q
A
L
E
R
------
R
------
P
A
K
V
V
A
V
G
E
I
G
L
D
L
----
F
G
--
D
-
D
----
P
Q
F
E
R
Q
Q
W
L
L
D
E
Q
L
K
L
A
K
R
Y
----
D
L
P
V
I
L
H
S
R
R
T
H
D
K
L
A
M
H
L
K
R
H
D
L
-------------------------
P
R
T
-
G
V
V
H
G
F
S
G
S
L
Q
Q
A
E
R
F
V
Q
-
L
--
G
Y
K
I
G
V
G
G
-
T
I
T
Y
P
-
R
-
A
S
K
T
R
D
V
I
A
K
L
P
L
A
S
L
L
L
E
T
D
A
P
D
-----
M
P
---------------
L
---
N
G
-
F
----------------------------------------
Q
-----
G
----
Q
-------
P
N
R
P
E
Q
A
A
R
V
F
A
V
L
C
E
L
R
R
E
P
A
D
E
I
A
Q
A
L
L
N
N
T
Y
T
L
F
N
V
P
---
7
PsiBlast_PDB
80.83
28%
-77
- C1 -
4PE8
1
TATD_ECOLI
A:
[1-256]
---
M
F
D
I
G
V
N
L
T
---
S
S
Q
F
---
A
----------
K
D
R
D
D
V
V
A
C
A
F
D
A
G
V
N
G
L
L
I
T
G
T
N
L
R
E
S
Q
----
Q
A
Q
K
L
A
R
Q
Y
----
S
----
S
----
C
W
S
T
A
G
V
H
P
-
H
D
S
S
Q
W
---
Q
----
A
-------------------
A
T
E
E
A
I
I
E
L
A
A
------
Q
------
P
-
E
V
V
A
I
G
E
C
G
L
D
F
----
N
R
N
-
F
-
S
----
T
P
-
E
E
Q
E
R
A
F
V
A
Q
L
R
I
A
A
D
L
----
N
M
P
V
F
M
H
C
R
D
A
H
E
R
F
M
T
L
L
E
P
W
L
D
------------------------
K
L
P
G
-
A
V
L
H
C
F
T
G
T
R
E
E
M
Q
A
C
V
A
-
H
--
G
I
Y
I
G
I
T
G
W
V
C
D
E
R
-
R
-
G
L
E
L
R
E
L
L
P
L
I
P
A
E
K
L
L
I
E
T
D
A
P
Y
-----
L
L
---------------
P
RDL
T
P
-
K
P---------------------------------------
S
-----
S
----
R
-------
R
N
E
P
A
H
L
P
H
I
L
Q
R
I
A
H
W
R
G
E
D
A
A
W
L
A
A
T
T
D
A
N
V
K
T
L
F
G
I
A
F
--
10
PsiBlast_PDB
80.51
28%
-95
- C1 -
2Y1H
5
TATD3_HUMAN
A:
[4-263]
-
V
G
L
V
D
C
H
C
H
L
S
---
A
P
D
F
---
D
----------
R
D
L
D
D
V
L
E
K
A
K
K
A
N
V
V
A
L
V
A
V
A
E
H
S
G
E
F
E
----
K
I
M
Q
L
S
E
R
Y
N---
G
----
F
----
V
L
P
C
L
G
V
H
P
-
V
Q
-------------RSVT
L
K
D
L
-----------
D
V
A
L
P
I
I
E
N
Y
K
------
D
--------
R
L
L
A
I
G
E
V
G
L
D
F
SPRF
A
G
T
-
G
-
E
----
Q
K
-
E
E
Q
R
Q
V
L
I
R
Q
I
Q
L
A
K
R
L
----
N
L
P
V
N
V
H
S
R
S
A
G
R
P
T
I
N
L
L
Q
E
Q
G
A
------------------------
E
K
V
---
L
L
H
A
F
D
G
R
P
S
V
A
M
E
G
V
R
-
A
--
G
Y
F
F
S
I
P
P
-
S
I
I
---
R
-
S
G
Q
K
Q
K
L
V
K
Q
L
P
L
T
S
I
C
L
E
T
D
S
P
A
-----
L
G
--------------------
P
-
E
----------------------------------------
K
-----
Q
----
V
-------
R
N
E
P
W
N
I
S
I
S
A
E
Y
I
A
Q
V
K
G
I
S
V
E
E
V
I
E
V
T
T
Q
N
A
L
K
L
F
P
K
L
R
H
L
6
PsiBlast_PDB
80.11
28%
-79
- C1 -
4P5U
-
TATD_ECOLI
A:
[1-256]
---
M
F
D
I
G
V
N
L
T
---
S
S
Q
F
---
A
----------
K
D
R
D
D
V
V
A
C
A
F
D
A
G
V
N
G
L
L
I
T
G
T
N
L
R
E
S
Q
----
Q
A
Q
K
L
A
R
Q
Y
----
S
----
S
----
C
W
S
T
A
G
V
H
P
-
H
D
S
S
Q
W
---
Q
----
A
-------------------
A
T
E
E
A
I
I
E
L
A
A
------
Q
------
P
-
E
V
V
A
I
G
E
C
G
L
D
F
----
N
R
N
-
F
-
S
----
T
P
-
E
E
Q
E
R
A
F
V
A
Q
L
R
I
A
A
D
L
----
N
M
P
V
F
M
H
C
R
D
A
H
E
R
F
M
T
L
L
E
P
W
L
D
------------------------
K
L
P
G
-
A
V
L
H
C
F
T
G
T
R
E
E
M
Q
A
C
V
A
-
H
--
G
I
Y
I
G
I
T
G
W
V
C
D
E
R
-
R
-
G
L
E
L
R
E
L
L
P
L
I
P
A
E
K
L
L
I
E
T
D
A
P
Y
-----
L
L
---------------
P
RDL
T
P
-
K
P---------------------------------------
S
-----
S
----
R
-------
R
N
E
P
A
H
L
P
H
I
L
Q
R
I
A
H
W
R
G
E
D
A
A
W
L
A
A
T
T
D
A
N
V
K
T
L
F
G
I
A
F
L
E
26
HHSearch
80.07
28%
-79
- C1 -
1XWY
1
TATD_ECOLI
A:
[5-263]
---
M
F
D
I
G
V
N
L
T
---
S
S
Q
F
---
A
----------
K
D
R
D
D
V
V
A
C
A
F
D
A
G
V
N
G
L
L
I
T
G
T
N
L
R
E
S
Q
----
Q
A
Q
K
L
A
R
Q
Y
----
S
----
S
----
C
W
S
T
A
G
V
H
P
-
H
D
S
S
Q
W
---
Q
----
A
-------------------
A
T
E
E
A
I
I
E
L
A
A
------
Q
------
P
-
E
V
V
A
I
G
E
C
G
L
D
F
----
N
R
N
-
F
-
S
----
T
P
-
E
E
Q
E
R
A
F
V
A
Q
L
R
I
A
A
D
L
----
N
M
P
V
F
M
H
C
R
D
A
H
E
R
F
M
T
L
L
E
P
W
L
D
------------------------
K
L
P
G
-
A
V
L
H
C
F
T
G
T
R
E
E
M
Q
A
C
V
A
-
H
--
G
I
Y
I
G
I
T
G
-
W
V
C
D
E
R
R
-
G
L
E
L
R
E
L
L
P
L
I
P
A
E
K
L
L
I
E
T
D
A
P
Y
-----
L
L
---------------
P
---
R
D
-
L
----------------------------------------
T
PKPS-
S
----
R
-------
R
N
E
P
A
H
L
P
H
I
L
Q
R
I
A
H
W
R
G
E
D
A
A
W
L
A
A
T
T
D
A
N
V
K
T
L
F
G
I
A
F
--
5
PsiBlast_PDB
79.66
28%
-81
- C1 -
1XWY
1
TATD_ECOLI
A:
[5-260]
---
M
F
D
I
G
V
N
L
T
---
S
S
Q
F
---
A
----------
K
D
R
D
D
V
V
A
C
A
F
D
A
G
V
N
G
L
L
I
T
G
T
N
L
R
E
S
Q
----
Q
A
Q
K
L
A
R
Q
Y
----
S
----
S
----
C
W
S
T
A
G
V
H
P
-
H
D
S
S
Q
W
---
Q
----
A
-------------------
A
T
E
E
A
I
I
E
L
A
A
------
Q
------
P
-
E
V
V
A
I
G
E
C
G
L
D
F
----
N
R
N
-
F
-
S
----
T
P
-
E
E
Q
E
R
A
F
V
A
Q
L
R
I
A
A
D
L
----
N
M
P
V
F
M
H
C
R
D
A
H
E
R
F
M
T
L
L
E
P
W
L
D
------------------------
K
L
P
G
-
A
V
L
H
C
F
T
G
T
R
E
E
M
Q
A
C
V
A
-
H
--
G
I
Y
I
G
I
T
G
W
V
C
D
E
R
-
R
-
G
L
E
L
R
E
L
L
P
L
I
P
A
E
K
L
L
I
E
T
D
A
P
Y
-----
L
L
---------------
P
RDL
T
P
-
K
P---------------------------------------
S
-----
S
----
R
-------
R
N
E
P
A
H
L
P
H
I
L
Q
R
I
A
H
W
R
G
E
D
A
A
W
L
A
A
T
T
D
A
N
V
K
T
L
F
G
I
A
F
--
9
PsiBlast_PDB
79.54
28%
-80
- C1 -
3RCM
3
?
A:
[2-268]
--
Q
L
I
D
I
G
V
N
L
T
---
N
S
S
F
---
H
----------
D
Q
Q
A
A
I
V
E
R
A
L
E
A
G
V
T
Q
M
L
L
T
G
T
S
L
A
V
S
E
----
Q
A
L
E
L
C
Q
Q
L
DASG
A
----
H
----
L
F
A
T
A
G
V
H
P
-
H
D
A
K
A
W
---
D
----
T
-------------------
D
S
E
R
Q
L
R
L
L
L
S
------
E
------
P
-
R
V
R
A
V
G
E
C
G
L
D
F
----
N
R
D
-
F
-
S
----
P
R
-
P
L
Q
E
K
A
L
E
A
Q
L
T
L
A
A
Q
L
----
R
L
P
V
F
L
H
E
R
D
A
S
E
R
L
L
A
I
L
K
D
Y
R
D
------------------------
H
L
T
G
-
A
V
V
H
C
F
T
G
E
R
E
A
L
F
A
Y
L
D
-
L
--
D
L
H
I
G
I
T
G
W
I
C
D
E
R
-
R
-
G
T
H
L
H
P
L
V
G
N
I
P
E
G
R
L
M
L
E
S
D
A
P
Y
LLPRS
L
R
---------------
P
---
K
P
-
K
----------------------------------------
S
-----
G
----
R
--------
N
E
P
A
F
L
P
E
V
L
R
E
V
A
L
H
R
G
E
S
A
E
H
T
A
A
H
T
T
A
T
A
R
D
F
F
Q
L
P
A
E
N
33
HHSearch
79.39
28%
-81
- C1 -
3RCM
3
?
A:
[1-267]
-
M
Q
L
I
D
I
G
V
N
L
T
---
N
S
S
F
---
H
----------
D
Q
Q
A
A
I
V
E
R
A
L
E
A
G
V
T
Q
M
L
L
T
G
T
S
L
A
V
S
E
----
Q
A
L
E
L
C
Q
Q
L
----
D
ASGA
H
----
L
F
A
T
A
G
V
H
P
-
H
D
A
K
A
W
---
D
----
T
-------------------
D
S
E
R
Q
L
R
L
L
L
S
------
E
------
P
-
R
V
R
A
V
G
E
C
G
L
D
F
----
N
R
D
-
F
-
S
----
P
R
-
P
L
Q
E
K
A
L
E
A
Q
L
T
L
A
A
Q
L
----
R
L
P
V
F
L
H
E
R
D
A
S
E
R
L
L
A
I
L
K
D
Y
R
D
-------------------------
H
L
T
G
A
V
V
H
C
F
T
G
E
R
E
A
L
F
A
Y
L
D
-
L
--
D
L
H
I
G
I
T
G
-
W
I
C
D
E
-
R
R
G
T
H
L
H
P
L
V
G
N
I
P
E
G
R
L
M
L
E
S
D
A
P
Y
-----
L
L
---------------
P
---
R
S
-
L
----------------------------------------
R
-----
P
KPKS
G
-------
R
N
E
P
A
F
L
P
E
V
L
R
E
V
A
L
H
R
G
E
S
A
E
H
T
A
A
H
T
T
A
T
A
R
D
F
F
Q
L
P
A
E
N
29
HHSearch
77.98
29%
-80
* C1 *
2XIO
3
TATD1_HUMAN
A:
[1-293]
-
M
K
F
I
D
I
G
I
N
L
T
---
D
P
M
F
---
R
GIYRGVQKHQ
D
D
L
Q
D
V
I
G
R
A
V
E
I
G
V
K
K
F
M
I
T
G
G
N
L
Q
D
S
K
----
D
A
L
H
L
A
Q
T
N
----
G
----
M
----
F
F
S
T
V
G
C
H
P
-
T
R
C
G
E
F
---
E
K
N
N
P
D
-------------------
L
Y
L
K
E
L
L
N
L
A
E
N
N
----
K
------
G
-
K
V
V
A
I
G
E
C
G
L
D
F
----
D
R
L
-
Q
F
C
----
P
K
-
D
T
Q
L
K
Y
F
E
K
Q
F
E
L
S
E
Q
T
----
K
L
P
M
F
L
H
C
R
N
S
H
A
E
F
L
D
I
T
K
R
N
R
D
------------------------
R
C
V
G
-
G
V
V
H
S
F
D
G
T
K
E
A
A
A
A
L
I
D
-
L
--
D
L
Y
I
G
F
N
G
-
C
S
L
K
T
----
E
A
N
L
E
V
L
K
S
I
P
S
E
K
L
M
I
E
T
D
A
P
W
-----
C
G
---------------
V
---
K
S
T
H
AGSKYIRTAFPTKKKWESGHC-------------------
L
-----
K
----
D
-------
R
N
E
P
C
H
I
I
Q
I
L
E
I
M
S
A
V
R
D
E
D
P
L
E
L
A
N
T
L
Y
N
N
T
I
K
V
F
F
P
V
---
31
HHSearch
76.01
30%
-76
- C1 -
2Y1H
5
TATD3_HUMAN
A:
[3-268]
G
V
G
L
V
D
C
H
C
H
L
S
---
A
P
D
F
---
D
----------
R
D
L
D
D
V
L
E
K
A
K
K
A
N
V
V
A
L
V
A
V
A
E
H
S
G
E
F
E
----
K
I
M
Q
L
S
E
R
Y
----
N
G---
F
----
V
L
P
C
L
G
V
H
P
-
V
Q
----RSV
T
----
L
-------------------
K
D
L
D
V
A
L
P
I
I
E
N
Y
----
K
------
D
-
R
L
L
A
I
G
E
V
G
L
D
F
----
S
P
R
-
F
-
A
GT
G
E
Q
K
-
E
E
Q
R
Q
V
L
I
R
Q
I
Q
L
A
K
R
L
----
N
L
P
V
N
V
H
S
R
S
A
G
R
P
T
I
N
L
L
Q
E
Q
G
--------------------------
A
E
K
-
V
L
L
H
A
F
D
G
R
P
S
V
A
M
E
G
V
R
-
A
--
G
Y
F
F
S
I
P
P
-
S
I
I
R
S
----
G
Q
K
Q
K
L
V
K
Q
L
P
L
T
S
I
C
L
E
T
D
S
P
A
-----
L
G
---------------
P
---
E
K
-
Q
---------------------------------------------------
V
-------
R
N
E
P
W
N
I
S
I
S
A
E
Y
I
A
Q
V
K
G
I
S
V
E
E
V
I
E
V
T
T
Q
N
A
L
K
L
F
P
K
L
R
H
L
8
PsiBlast_PDB
75.45
27%
-79
- C1 -
2XIO
3
TATD1_HUMAN
A:
[22-290]
---------------
V
Q
K
H
---
Q
----------
D
D
L
Q
D
V
I
G
R
A
V
E
I
G
V
K
K
F
M
I
T
G
G
N
L
Q
D
S
K
----
D
A
L
H
L
A
Q
T
N
----
G
----
M
----
F
F
S
T
V
G
C
H
P
-
T
R
C
G
E
F
---
E
----
K
-------------------
N
N
P
D
L
Y
L
K
E
L
L
------
N
L
A
E
N
N
K
G
-
K
V
V
A
I
G
E
C
G
L
D
F
----
D
R
L
-
Q
F
C
----
P
K
-
D
T
Q
L
K
Y
F
E
K
Q
F
E
L
S
E
Q
T
----
K
L
P
M
F
L
H
C
R
N
S
H
A
E
F
L
D
I
T
K
R
N
R
D
------------------------
R
C
V
G
-
G
V
V
H
S
F
D
G
T
K
E
A
A
A
A
L
I
D
-
L
--
D
L
Y
I
G
F
N
G
--
C
S
L
K
-
T
-
E
A
N
L
-
E
V
L
K
S
I
P
S
E
K
L
M
I
E
T
D
A
P
W
-----
C
G
VKSTHAGSKYIRTAF
P
---
T
K
-
K
----------------------------------------
K
-----
W
----
E
SGHCLKD
R
N
E
P
C
H
I
I
Q
I
L
E
I
M
S
A
V
R
D
E
D
P
L
E
L
A
N
T
L
Y
N
N
T
I
K
V
F
F
P
V
---
35
HHSearch
74.31
23%
-81
- C1 -
3IPW
1
?
A:
[25-323]
A
Q
Q
F
I
D
I
G
A
N
L
T
---
D
D
N
Y
---
F
GNYHGKHYHE
E
D
I
D
V
V
L
Q
R
A
E
R
N
G
L
S
H
I
I
I
T
S
G
C
L
N
D
F
K
----
K
A
I
E
I
I
N
K
Y
----
Q
N---
L
TN
I
K
L
V
T
T
I
G
V
H
P
-
T
R
T
N
E
L
---
K
Q---
E
-------------------
G
Y
L
D
E
L
L
L
L
C
E
K
N
----
I
------
D
-
K
V
V
A
I
G
E
I
G
L
D
Y
----
E
R
L
-
Q
F
S
----
D
K
-
E
T
Q
L
S
G
Y
R
T
L
S
I
L
H
Q
K
Y
P---
Y
L
P
F
F
F
H
C
R
K
S
W
S
D
L
C
Q
L
N
K
E
L
G
Y
------------------------
N
G
C
K
-
G
V
V
H
C
F
D
G
T
E
E
E
M
N
Q
I
L
N
-
E
--
G
W
D
I
G
V
T
G
-
N
S
L
Q
S
----
I
E
L
L
N
V
M
K
Q
I
P
I
E
R
L
H
I
E
T
D
C
P
Y
-----
C
G
---------------
I
---
K
K
-
T
SAGFKYLKEKDFGVKVEKY---------------------
Q
RNKYV
Q
----
R
-------
R
N
E
P
S
N
I
I
D
I
A
I
I
M
S
S
I
K
H
I
S
L
F
E
F
V
N
K
V
Y
S
N
S
M
N
M
Y
F
P
T
---
32
HHSearch
71.15
22%
-77
- C1 -
3E2V
3
?
A:
[12-393]
-
L
K
Y
Y
D
I
G
L
N
L
T
---
D
P
M
F
---
H
GIYNGKQYHP
A
D
Y
V
K
L
L
E
R
A
A
Q
R
H
V
K
N
A
L
V
T
G
S
S
I
A
E
S
Q
S
A
I
E
L
V
S
S
V
K
D
L
S
----
P
L---
K
----
L
Y
H
T
I
G
V
H
P
-
C
C
V
N
E
F
---
A
-----E
A
Y
N
E
S
L
Y
A
K
V
I
S
NP
S
F
A
Q
G
K
L
K
E
L
Y
D
L
M
N
Q
Q
A
KPH
D
------
T
-
S
F
R
S
I
G
E
I
G
L
D
Y
----
D
R
F
H
Y
-
S
----
S
K
-
E
M
Q
K
V
F
F
E
E
Q
L
K
I
S
C
L
N
D
K
L
S
S
Y
P
L
F
L
H
M
R
S
A
C
D
D
F
V
Q
I
L
E
R
F
V
V
G
F
T
D
EKDTFQLQKLSSSSG
F
Y
K
F
H
P
D
R
K
-
L
V
V
H
S
F
T
G
S
A
I
D
L
Q
K
L
L
N
-
L
SP
N
I
F
I
G
V
N
G
-
C
S
L
R
T
----
E
E
N
L
A
V
V
K
Q
I
P
T
E
R
L
L
L
E
T
D
A
P
W
-----
C
E
---------------
I
---
K
R
-
T
HAS
F
Q
Y
L
A
K
Y
Q
E
VRDFEYPA
F
K
S
V
K
KNKLADKLNAE
E
L
Y
M
V
-----
K
----
G
-------
R
N
E
P
C
N
M
E
Q
V
A
I
V
V
S
E
V
K
D
V
D
L
A
T
L
I
D
T
T
W
K
T
T
C
K
I
F
G
-----