@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu01830: (2016-06-03 )
MLVSLSLSSLLTLFFIMLMASGISGLLFLHPRVPLSFVRIHIGILALPLLVSLLILANSGVSGNVGPWHLDSLACLMTFFVLAIGFIIQRFSVRYLMGDRSYRKYFTLFTFTTGAASMTWLSGDLRLMVLFWGATLVGLTLLIRLNSAWQVASEAAKISGRLFLLSWFSLFFAMMWLFHATGQWQLSLVVTNESLAGLGEWERTGIQLLIVLAVIIPAAQWPFQRWLVESIVAPTPVSAIMHAGLVNAGGIILTRFSPLFHGGIASIILLLLASISVLIGTGISLVQVDYKRQLVGSTIGQMGFMLIQCALGAYIAAIIHLILHGLFKATLFLQAGSAVGRHEVSTRTNERTSYLWVMAGRILSLVIGVAFWLTAPGDGYHLISALILGWSLSVSWDQLVAFGEGRIGRIAGLTVLGGAALVYFIIHHLFYKWLHTTIFQSVQPPMSAVMIVVCLLLFGSALGTWVARHRSSVFFAVLYLWLVRLGEAKPKSVESHPDYLKQYIS
Atome Classification :
(20 SA)
-----.........10....-....20.....--.--..30--.-.......40........50.......--.--------60--.........------------70........80........90........-100.......110-.......120.......130...------....140...---....----150........160.......170..-..----...180--.--...-...190-.-.....---..200.......210....-...220.......230.-..-.-....240.-.-.....--250-.....-..-260-----.--.---....--..270........280.......290.......-300.......310-------.-----.---......320.......330.......--340-....-...350-----........360.......370.......-380.......390.......400.......-----410.......420.......430.......440.......450.--------......460-......---------------.470.......480----........490.......500....-----------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----
M
L
VSL
S
L
S
S
L
L
T
L
F
F
-
I
M
L
M
A
SGIS
G
L
--
L
--
F
LHP--R-V
P
L
S
F
V
R
I
H
I
G
I
L
A
L
P
L
L
V
S
L
L
I
L
AN--S--------G---VSGNVG
P
W
H
------------
L
D
S
L
A
C
L
M
T
F
F
V
L
A
I
G
F
I
I
Q
R
F
S
V
R
Y
L
MGD-RS
Y
R
K
Y
F
T
L
F
T
FT-TGA
A
S
M
T
W
LSGD
L
R
L
M
V
L
FW
G
A
T
------
L
V
G
L
T
L
L
IRL---N
S
A
W
----
Q
V
-
A
S
E
A
A
K
ISG
R
L
F
L
L
S
W
F
S
L
F
F
A
M
-
M
W
----
L
FHATG--
Q
--
W
Q
L
-
S
L
V
V
T--N-ESLAG---LG
E
W
E
RT
G
I
Q
L
L
I
V
L
A
V
I
I-PAAQW
P
F
Q
R
W
L
V
E
SI-V-AP-
T
-
P
V
S
A
I
M
H
A
-G-LVNA
G
--
G
I
I
-
L
T
R
F
S
-
P
L
-F-H-----G--
G
---
I
A
S
I
--
I
L
L
-
L
L
A
S
I
S
V
L
I
GTG
I
S
L
V
Q
V
D
Y
K
R
Q
L
V
G
S
T
I
-
G
Q
M
G
F
M
L
I
Q
C
A
L
--------
G
-----
A
---
Y
I
A
A
I
I
H
L
I
L
H
G
L
F
K
A
T
L
F
LQAGSAV--GRH-EVST-RTNER------
T
S
Y
L
W
V
M
A
G
R
I
L
S
L
V
I
G
V
A
F
W
LTAPGD
G
-
Y
H
L
I
S
A
L
I
LGWS
L
S
V
S
W
D
Q
L
V
A
FGEGRI
G
R
-----
I
A
G
L
T
VL
G
G
A
A
L
V
Y
F
I
I
H
H
L
F
Y
K
W
L
H
T
T
I
F
Q
SVQP
P
M
S
A
V
M
I
V
V
--------
C
L
L
L
F
G
S
A
L
-
G
T
W
V
A
R
---------------
H
R
S
S
V
F
F
A
V
L
Y
L
W
-----
L
V
RLGEAKPKSVES
H
P
D
Y
L
-
K
Q
YIS-----------------------------------------------------------------------------------------
14
Fugue
92.14
22%
-151
- C3 -
3RKO
4
?
B:
[1-612]
-----------
M
N
M
L
A
L
T
I
I
-
L
P
L
I
G
F
V
L
L
A
F
--
S
RG
R
W
S
E
--
N
-
V
S
A
I
V
G
V
G
S
V
G
L
A
A
L
V
T
A
F
I
G
V
D
F
F
A
--
N
--------
G
E
Q
T
Y
S
Q
P
L
W
T
W
M
SVGD
F
N
I
G
F
N
L
V
L
D
G
L
S
L
T
M
L
S
V
V
T
G
V
G
F
L
I
H
M
Y
A
S
W
Y
M
R
G
E
-
E
G
Y
S
R
F
F
A
Y
T
N
L
F
-
I
A
S
M
V
V
L
V
L
A
D
N
L
L
L
M
Y
L
G
W
E
G
V
------
G
L
C
S
Y
L
L
I
G
F
---
Y
Y
T
D
----
P
K
-
N
G
A
A
A
M
K
A
F
V
V
T
R
V
G
D
V
F
L
A
F
A
L
-
F
I
----
L
Y
N
E
L
G
--
T
--
L
N
F
-
R
E
M
V
E
--
L
A
P
A
H
F
A
---
D
G
N
N
M
L
M
W
A
T
L
M
L
L
G
G
A
V
G
-
K
S
A
Q
L
P
L
Q
T
W
L
A
D
A
M
-
A
-
G
P
-
T
-
P
V
S
A
L
I
H
A
A
T
-
M
V
T
A
G
--
V
Y
L
-
I
A
R
T
H
-
G
L
-
F
L
M
-----
T
--
P
---
E
V
L
H
--
L
V
G
-
I
V
G
A
V
T
L
L
L
A
G
F
A
A
L
V
Q
T
D
I
K
R
V
L
A
Y
S
T
M
-
S
Q
I
G
Y
M
F
L
A
L
G
V
--------
Q
-----
A
---
W
D
A
A
I
F
H
L
M
T
H
A
F
F
K
A
L
L
F
L
A
S
G
S
V
I
--
L
A
C
-
H
--------
H
------
E
Q
N
I
F
K
M
G
G
--
L
R
K
S
I
P
L
V
Y
L
C
F
L
V
G
G
---
A
A
L
S
A
L
P
L
V
T
A
G
F
F
S
K
D
E
I
L
A
G
A
M
A
N
G
H
I
-----
N
L
M
V
A
G
L
V
G
A
F
M
T
S
L
Y
T
F
R
M
I
F
I
V
F
H
G
K
E
Q
I
H
A
H
A
V
K
G
V
T
H
S
L
P
--------
L
I
V
L
L
I
L
S
T
-
F
V
G
A
L
I
VPPLQGVLPQTTELA
H
G
S
M
L
T
L
E
I
T
S
G
V
-----
V
A
V
V
G
I
L
L
A
A
W
L
W
L
G
K
R
T
L
-
V
T
S
I
A
N
S
A
P
G
R
L
L
S
T
W
W
Y
N
AWG
F
D
W
L
Y
D
K
VF
V
K
P
F
L
G
I
A
W
L
L
KRD
P
L
N
S
M
M
N
I
P
A
V
L
S
R
F
A
G
K
G
L
L
LSENGY
L
R
W
Y
V
A
S
M
S
I
G
A
V
V
V
L
A
L
L
M
V
L
5
HHSearch
82.06
24%
-155
- C3 -
4HE8
1
NQO12_THET8
L:
[3-348]
---------------
L
L
G
T
I
-
L
L
P
L
L
G
F
A
L
L
G
--
L
--
F
G
K
R
--
M
-
R
E
P
L
P
G
V
L
A
S
G
L
V
L
A
S
F
L
L
G
A
G
L
L
L
S
--
G
GARFQA--
E
W--
L
P
G
I
P
F
S
L
L
------------
L
D
N
L
S
G
F
M
L
L
I
V
T
G
V
G
F
L
I
H
V
Y
A
I
G
Y
M
G
G
D
-
P
G
Y
S
R
F
F
A
Y
F
N
L
F
-
I
A
M
M
L
T
L
V
L
A
D
S
Y
P
V
M
F
I
G
W
E
G
V
------
G
L
A
S
F
L
L
I
G
F
---
W
Y
K
N
----
P
Q
-
Y
A
D
S
A
R
K
A
F
I
V
N
R
I
G
D
L
G
F
M
L
G
M
-
A
I
----
L
W
A
L
Y
G
--
T
--
L
S
I
-
S
E
L
K
E
--
A
---
M
E
G
PL-
K
N
P
D
L
L
A
L
A
G
L
L
L
F
L
G
A
V
G
-
K
S
A
Q
I
P
L
M
V
W
L
P
D
A
M
-
A
-
G
P
-
T
-
P
V
S
A
L
I
H
A
-
A
T
M
V
T
A
G
--
V
Y
L
-
I
A
R
S
S
-
F
L
-
Y
-
S
-----
V
--
L
P--
D
V
S
Y
--
A
I
A
-
V
V
G
L
L
T
A
A
Y
G
A
L
S
A
F
G
Q
T
D
I
K
K
I
V
A
Y
S
T
I
-
S
Q
L
G
Y
M
F
L
A
A
G
V
--------
G
-----
A
---
Y
W
V
A
L
F
H
V
F
T
H
A
F
F
K
A
L
L
F
L
A
S
G
S
V
I
--
H
A
L
G
G
E
Q
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
80.63
18%
-135
- C3 -
4HE8
1
NQO13_THET8
G:
[1-467]
-----
M
V
V
L
A
V
L
L
P
V
V
F
G
A
L
-
L
L
L
G
L
P
R
A
L
G
V
--
L
--
G
A
G
L
--
S
-
F
L
L
N
L
Y
L
F
L
T
H
P
G
G
V
A
H
A
F
Q
A
P
L
L
P
G
--
A
--------
G
---
V
Y
W
A
F
G
L
D
G
------------
L
S
A
L
F
F
L
T
I
A
L
T
V
F
L
G
A
L
V
----------
A
-
R
V
E
G
R
F
L
G
L
A
L
L
M
-
E
G
L
L
L
G
L
F
A
A
R
D
L
L
V
F
Y
V
F
F
E
A
A
------
L
I
P
A
L
L
M
L
Y
L
---
Y
G
G
-----
E
G
-
R
T
R
A
L
Y
T
F
V
L
F
T
L
V
G
S
L
P
M
L
A
A
V
-
L
G
----
A
R
L
L
S
G
--
S
--
P
T
F
-
L
L
E
D
L
--
L
-
A
H
P
L
Q
---
E
E
A
A
F
W
V
F
L
G
F
A
L
A
F
A
I
K
T
-
P
L
--
F
P
L
H
A
W
L
P
P
F
H
-
Q
E
N
H
-
P
-
S
G
L
A
D
A
L
G
-
T
-
L
Y
K
V
G
--
V
F
A
-
F
F
R
F
A
I
P
L
-
A
-
P
-----
E
--
G
---
F
A
Q
A
QG
L
L
L
-
F
L
A
A
L
S
A
L
Y
G
A
W
V
A
F
A
A
K
D
F
K
T
L
L
A
Y
A
G
L
-
S
H
M
G
V
A
A
L
G
V
F
S
--------
G
TPE--
G
---
A
M
G
G
L
Y
L
L
A
A
S
G
V
Y
T
G
G
L
F
L
L
A
G
R
L
Y
--
E
R
T
------
G
T
L
E
I
------
G
R
Y
R
G
L
A
Q
S
A
P
G
L
A
A
L
A
L
I
L
F
L
A
M
V
G
L
--------------------------
P
G
L
S
G
F
-----
P
G
E
F
L
T
L
L
G
A
Y
K
A
S
--------
P
W
L
A
A
L
A
F
L
S
V
I
A
S
A
A
Y
A
L
T
A
F
--------
Q
K
T
F
W
E
E
G
G
S
G
V
K
D
L
A
---------------
G
A
E
W
G
F
A
L
L
S
V
L
A
-----
L
L
L
M
G
V
F
P
G
Y
F
A
R
G
L
H
P
L
A
-
E
A
F
A
K
LLGG-------------------------------------------------------------------------------------
21
Fugue
80.52
16%
-153
- C4 -
5DBJ
2
?
D:
[5-441]
SDHDY
D
V
V
I
I
G
G
G
P
A
G
S
T
M
A
-
S
Y
L
A
K
A
G
V
K
C
A
--
V
--
F
E
K
E
--
L
-----
F
E
R
E
H
V
G
E
S
L
V
P
A
T
T
P
V
L
L
E
I
------------
G
---
V
M
E
K
I
E
K
A
N
------------
F
P
K
K
--------
F
G
A
A
W
T
S
A
D
S
G
P
E
D
K
M
G
F
-
Q
G
L
D
H
D
F
R
S
A
E
I
L
-
F
N
E
R
K
Q
E
G
V
D
R
D
F
T
F
H
V
---
D
R
G
------
K
F
D
R
I
L
L
E
H
A
---
G
S
L
G
----
A
K
-
V
F
Q
G
V
E
I
A
D
V
E
F
L
S
P
--
G
N
V
I
V
N
-
A
K
----
L
G
K
R
S
V
--
E
--
I
K
A
-
K
M
V
V
D
--
A
---------------
S
G
R
N
V
L
L
G
R
R
L
G
L
-
R
E
K
D
P
V
F
N
Q
F
A
I
H
S
W
-
F
-
D
N
-
F
-
D
R
K
S
A
T
Q
S
-
P
---
D
K
V
--
D
Y
I
-
F
I
H
F
L
-
P
M
-
T
-
N
-----
T
--
W
---
V
W
Q
I
--
P
I
T
----------
E
T
I
T
S
V
G
V
V
T
Q
K
Q
N
Y
T
N
S
D
L
-
T
Y
E
E
F
F
W
E
A
V
K
T
--------
R
-----
E
---
N
L
H
D
A
L
K
A
S
E
Q
---
V
R
P
F
K
K
E
A
D
Y
S
Y
--
G
M
K
-
E
V
C
G
-
D
S
-------------
F
V
L
I
G
D
A
A
R
F
V
D
----
P
I
F
S
S
G
V
S
-
V
A
L
N
S
A
R
I
A
S
G
D
I
I
E
A
V
K
N
N
-
D
F
S
K
S
S
F
T
H
-----
Y
E
G
M
I
R
N
G
I
K
N
W
Y
E
F
I
T
L
Y
Y
R
L
N
I
L
F
T
A
F
V
Q
D
-----
P
R
Y
R
L
D
I
--------
L
Q
L
L
Q
G
D
---------------------------------
V
Y
L
E
-----
V
L
D
K
M
R
E
I
I
A
A
V
E
S
D
P
E
H
L
W
H
K
Y
L
G
-----------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.74
28%
-149
- C3 -
4HE8
1
NQO12_THET8
L:
[69-351]
-----------------------------------------------------------------------------------------------------------
L
D
N
L
S
G
F
M
L
L
I
V
T
G
V
G
F
L
I
H
V
Y
A
I
G
Y
M
G
G
D
-
P
G
Y
S
R
F
F
A
Y
F
N
L
F
-
I
A
M
M
L
T
L
V
L
A
D
S
Y
P
V
M
F
I
G
W
E
G
V
------
G
L
A
S
F
L
L
I
G
F
WYK
N
P
Q
Y
----
A
D
-
S
A
R
K
A
F
I
V
N
R
I
G
D
L
G
-
F
M
L
G
M
A
I
-
L
W
----
A
L
Y
G
T
--------
L
-
S
I
S
E
L
--
K
-
E
A
M
E
G
P--
L
K
N
P
D
L
L
A
L
A
G
L
L
L
F
L
G
A
V
G
K
S
A
Q
I
P
L
M
V
W
L
P
D
A
M
-
A
-
G
P
-
T
-
P
V
S
A
L
I
H
A
-
A
T
M
V
T
A
G
--
V
Y
L
-
I
A
R
S
S
-
F
L
-
Y
-
S
VLPDV
S
--
Y
---
A
I
A
V
--
V
G
L
-
L
T
A
A
Y
G
A
L
S
A
F
G
----
Q
T
D
I
K
K
I
V
A
Y
S
T
I
-
S
Q
L
G
Y
M
F
L
A
A
G
V
--------
G
-----
A
---
Y
W
V
A
L
F
H
V
F
T
H
A
F
F
K
A
L
L
F
L
A
S
G
S
V
I
----
H
-
A
L
G
G
-
E
Q
D
V
R
------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
79.62
28%
-148
- C3 -
4HEA
-
NQO12_THET8
L:
[69-351]
-----------------------------------------------------------------------------------------------------------
L
D
N
L
S
G
F
M
L
L
I
V
T
G
V
G
F
L
I
H
V
Y
A
I
G
Y
M
G
G
D
-
P
G
Y
S
R
F
F
A
Y
F
N
L
F
-
I
A
M
M
L
T
L
V
L
A
D
S
Y
P
V
M
F
I
G
W
E
G
V
------
G
L
A
S
F
L
L
I
G
F
WYK
N
P
Q
Y
----
A
D
-
S
A
R
K
A
F
I
V
N
R
I
G
D
L
G
-
F
M
L
G
M
A
I
-
L
W
----
A
L
Y
G
T
--------
L
-
S
I
S
E
L
--
K
-
E
A
M
E
G
P--
L
K
N
P
D
L
L
A
L
A
G
L
L
L
F
L
G
A
V
G
K
S
A
Q
I
P
L
M
V
W
L
P
D
A
M
-
A
-
G
P
-
T
-
P
V
S
A
L
I
H
A
-
A
T
M
V
T
A
G
--
V
Y
L
-
I
A
R
S
S
-
F
L
-
Y
-
S
VLPDV
S
--
Y
---
A
I
A
V
--
V
G
L
-
L
T
A
A
Y
G
A
L
S
A
F
G
----
Q
T
D
I
K
K
I
V
A
Y
S
T
I
-
S
Q
L
G
Y
M
F
L
A
A
G
V
--------
G
-----
A
---
Y
W
V
A
L
F
H
V
F
T
H
A
F
F
K
A
L
L
F
L
A
S
G
S
V
I
----
H
-
A
L
G
G
-
E
Q
D
V
R
------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
78.49
18%
-134
* C4 *
4OPU
3
?
A:
[2-453]
--------------
M
K
E
L
K
Y
D
V
L
I
I
G
G
G
F
A
G
S
--
S
--
A
A
Y
Q
L
S
R
-
R
G
L
K
I
L
L
V
D
S
K
P
W
N
R
--------
I
G
D
--
K
--------
P
---
C
G
D
A
V
S
K
A
H
------------
F
D
K
L
------------------
G
M
P
Y
P
K
G
E
-
E
L
E
N
K
I
N
-----------
G
I
K
L
Y
S
P
D
---
M
Q
T
V
W
T
V
N
------
H
E
G
F
E
L
N
A
P
L
---
Y
N
Q
-----
R
V
-
L
K
E
A
Q
D
R
G
V
E
I
W
D
L
-------
T
T
-
A
M
----
K
P
I
F
E
D
--
G
--
Y
V
K
-
G
A
V
L
F
--
N
-
R
------------
R
T
N
E
E
L
T
V
Y
S
K
V
V
V
-
E
A
T
G
--
Y
S
R
S
F
R
S
K
L
-
P
-
P
E
-
L
-
P
I
T
E
D
L
D
D
-
K
-
D
A
D
V
A
Y
R
E
V
L
-
L
T
K
E
D
-
I
E
-
D
-
H
-----
D
------------
Y
L
R
-
I
F
I
D
Q
E
T
S
P
G
G
Y
W
W
Y
F
P
K
G
K
N
K
V
N
V
G
L
G
I
Q
G
G
M
G
Y
P
S
I
H
E
Y
Y
--------
K
-----
K
---
Y
L
D
K
Y
A
P
----
D
V
D
K
S
K
L
L
V
K
-------
G
G
A
-
L
V
P
T
-
R
---
R
------
P
L
Y
T
M
A
W
N
G
---
I
I
V
I
G
D
S
G
F
T
V
N
P
V
H
G
-
G
G
K
G
S
A
M
I
S
G
Y
C
A
A
K
A
I
L
S
A
F
E
T
G
D
F
S
A
S
G
LW
D
M
N
I
C
Y
V
N
E
Y
G
A
K
Q
A
S
L
D
I
F
R
R
F
L
Q
K
L
S
N
D
D
I
N
Y
G
M
K
K
K
I
I
K
E
E
D
L
L
E
A
S
E
KGDL
H
L
S
V
A
D
K
A
M
-
R
V
I
S
G
L
---------------
G
R
P
S
L
L
F
K
L
K
A
V
A
E
S
M
K
K
I
K
E
L
Y
L
N
Y
P
R
S
P
S
S
L
G
S
W
R
-
R
E
V
D
N
V
L
T
E
F
N
K
S
L
S-------------------------------------------------------------------------------
4
HHSearch
77.06
28%
-144
- C3 -
3RKO
4
?
L:
[75-361]
-----------------------------------------------------------------------------------------
I
G
F
N
L
V
------------
L
D
G
L
S
L
T
M
L
S
V
V
T
G
V
G
F
L
I
H
M
Y
A
S
W
Y
M
R
G
E
-
E
G
Y
S
R
F
F
A
Y
T
N
L
F
-
I
A
S
M
V
V
L
V
L
A
D
N
L
L
L
M
Y
L
G
W
E
G
V
------
G
L
C
S
Y
L
L
I
G
F
---
Y
Y
T
D
----
P
K
-
N
G
A
A
A
M
K
A
F
V
V
T
R
V
G
D
V
F
L
A
F
A
L
-
F
I
----
L
Y
N
E
L
G
--
T
--
L
N
F
-
R
E
M
V
E
--
L
---
A
P
A
HFA
D
G
N
N
M
L
M
W
A
T
L
M
L
L
G
G
A
V
G
-
K
S
A
Q
L
P
L
Q
T
W
L
A
D
A
M
-
A
-
G
P
-
T
-
P
V
S
A
L
I
H
A
-
A
T
M
V
T
A
G
--
V
Y
L
-
I
A
R
T
H
-
G
L
-
F
-
L
-----
M
--
T
P--
E
V
L
H
--
L
V
G
-
I
V
G
A
V
T
L
L
L
A
G
F
A
A
L
V
Q
T
D
I
K
R
V
L
A
Y
S
T
M
-
S
Q
I
G
Y
M
F
L
A
L
G
V
--------
Q
-----
A
---
W
D
A
A
I
F
H
L
M
T
H
A
F
F
K
A
L
L
F
L
A
S
G
S
V
I
--
L
A
C
H
H
E
Q
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
74.90
20%
-146
- C3 -
4HE8
-
NQO13_THET8
M:
[1-345]
--------------
M
V
V
L
A
V
-
L
L
P
V
V
F
G
A
L
L
L
--
L
--
G
--
L
-----
P
---
R
A
L
G
V
L
G
A
G
L
S
F
L
L
N
L
Y
L
F
L
T
HP
G
GVAHAFQA
P
LLP
G
A
G
V
Y
W
A
F
G
------------
L
D
G
L
S
A
L
F
F
L
T
I
A
L
T
V
F
L
G
A
L
V
A
--------
R
V
E
G
R
F
L
G
L
A
L
L
M
-
E
G
L
L
L
G
L
F
A
A
R
D
L
L
V
F
Y
V
F
F
E
A
A
------
L
I
P
A
L
L
M
L
Y
L
---
Y
G
G
-----
E
G
-
R
T
R
A
L
Y
T
F
V
L
F
T
L
V
G
S
L
P
M
L
A
A
V
-
L
G
----
A
R
L
L
S
G
--
S
PT
F
L
L
-
E
D
L
L
A
--
H
-----
P
---
L
Q
E
E
A
A
F
W
V
F
L
G
F
A
L
A
F
A
I
-
K
T
P
L
F
P
L
H
A
W
L
P
P
F
H
-
Q
-
E
N
H
P
-
S
G
L
A
D
A
L
G
-
T
-
L
Y
K
V
G
--
V
F
A
-
F
F
R
F
A
-
I
P
-
L
-
A
-----
P
--
E
GFA
Q
A
Q
G
--
L
L
L
-
F
L
A
A
L
S
A
L
Y
G
A
W
V
A
F
A
A
K
D
F
K
T
L
L
A
Y
A
G
L
-
S
H
M
G
V
A
A
L
G
V
F
S
--------
G
-----
T
PEG
A
M
G
G
L
Y
L
L
A
A
S
G
V
Y
T
G
G
L
F
L
L
A
G
R
L
Y
--
E
R
T
-
G
T
L
E
I
G
R
Y
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
74.42
24%
-136
- C3 -
3RKO
2
?
M:
[78-375]
------------------------------------------------------------------------------------------
S
I
H
L
A
------------
I
D
G
L
S
L
L
M
V
V
L
T
G
L
L
G
V
L
A
V
L
C
S
W
K
E
I
E
---
K
Y
Q
G
F
F
H
L
N
L
M
W
I
-
L
G
G
V
I
G
V
F
L
A
I
D
M
F
L
F
F
F
F
W
E
M
M
------
L
V
P
M
Y
F
L
I
A
L
---
W
G
H
K
ASDG
K
T
-
R
I
T
A
A
T
K
F
F
I
Y
T
Q
A
S
G
L
V
M
L
I
A
I
-
L
A
LVFV
H
Y
N
A
T
G
VW
T
--
F
N
Y
-
E
E
L
L
N
--
T
---
P
-----
M
S
S
G
V
E
Y
L
L
M
L
G
F
F
I
A
F
A
V
-
K
M
P
V
V
P
L
H
G
W
L
P
D
A
H
S
Q
-
A
P
-
T
-
A
G
S
V
D
L
A
G
-
I
-
L
L
K
T
A
--
A
Y
G
-
L
L
R
F
S
-
L
P
L
F
-
P
-----
N
A-
S
A--
E
F
A
P
--
I
A
M
-
W
L
G
V
I
G
I
F
Y
G
A
W
M
A
F
A
Q
T
D
I
K
R
L
I
A
Y
T
S
V
-
S
H
M
G
F
V
L
I
A
I
Y
T
--------
G
SQL--
A
---
Y
Q
G
A
V
I
Q
M
I
A
H
G
L
S
A
A
G
L
F
I
L
C
G
Q
L
Y
--
E
R
I
-
H
T
R
D
M
R
M
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
72.74
29%
-138
- C3 -
3RKO
4
?
L:
[81-359]
-----------------------------------------------------------------------------------------------------------
L
D
G
L
S
L
T
M
L
S
V
V
T
G
V
G
F
L
I
H
M
Y
A
S
W
Y
M
R
G
E
-
E
G
Y
S
R
F
F
A
Y
T
N
L
F
-
I
A
S
M
V
V
L
V
L
A
D
N
L
L
L
M
Y
L
G
W
E
G
V
GLCSYL
L
I
G
F
Y
Y
T
D
P
K
---
N
G
A
A
----
A
M
-
K
A
F
V
V
T
R
V
G
D
V
F
L
A
------
F
A
L
-
F
I
----
L
Y
N
E
L
G
--
T
--
L
N
F
R
E
M
V
E
L
--
A
-
P
A
H
F
A
---
D
G
N
N
M
L
M
W
A
T
L
M
L
L
G
G
A
V
G
-
K
S
A
Q
L
P
L
Q
T
W
L
A
D
A
M
-
A
-
G
P
-
T
-
P
V
S
A
L
I
H
A
-
A
T
M
V
T
A
G
--
V
Y
L
-
I
A
R
T
H
-
G
L
-
F
-
L
-----
M
--
T
---
P
E
V
L
--
H
L
V
G
I
V
G
A
V
T
L
L
L
A
G
F
A
A
L
V
Q
T
D
I
K
R
V
L
A
Y
S
T
M
-
S
Q
I
G
Y
M
F
L
A
L
G
V
--------
Q
-----
A
---
W
D
A
A
I
F
H
L
M
T
H
A
F
F
K
A
L
L
F
L
A
S
G
S
V
I
LA
C
H
H
-
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
71.16
19%
-143
- C3 -
4QIQ
1
XYLE_ECOLI
A:
[7-470]
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
-
T
A
V
I
S
G
T
V
E
S
L
N
T
V
--
F
V
A
P
--
Q
N
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
--
L
--------
G
---
G
Y
C
S
N
R
F
G
R
------------
R
D
S
L
K
I
A
A
V
L
F
-----
F
I
S
G
V
G
S
A
W
P
E
L
G
F
-
T
S
I
N
P
D
N
T
V
P
----------
V
Y
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
------
G
I
G
V
G
L
A
S
M
L
---
S
P
M
Y
----
I
A
-
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
-
L
L
----
V
Y
C
V
N
Y
--
F
--
I
A
R
-
S
------------
G
---
D
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
-
P
A
L
L
F
L
M
L
L
Y
T
V
-------
P
-
E
-
S
P
R
W
L
M
T
L
-
A
-
T
Q
A
V
Q
--
E
I
K
-
H
S
L
D
R
-
L
L
-
M
-
F
-----
G
--
V
---
G
V
I
V
--
I
G
V
-
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
-
D
I
A
L
L
Q
T
I
I
V
G
V
--------
I
-----
N
---
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
----------------------
R
K
P
L
Q
------
I
I
G
A
L
G
M
A
I
G
M
F
S
L
--
G
T
A
F
Y
T
Q
A
P
G
-
I
-
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
--------
G
P
V
C
W
-----
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
--
S
W
--------
L
V
A
H
F
H
N
G
F
-
S
Y
W
I
Y
G
---------------
C
M
G
--
V
L
A
A
L
F
M
W
-----
K
F
-
V
P
E
T
K
G
K
T
L
------------------------------------------------------------------------------------------------------
9
HHSearch
66.57
23%
-145
- C3 -
4HE8
1
NQO14_THET8
N:
[50-304]
------------------------------------------------------------------------------------------
F
G
P
Y
A
------------
V
D
G
V
S
Q
V
F
T
L
L
A
L
L
G
----
A
L
W
T
V
G
L
V
R
---
S
G
R
F
E
F
Y
L
L
V
L
Y
A
-
A
L
G
M
H
L
L
A
S
T
R
H
L
L
L
M
L
V
A
L
E
A
L
------
S
L
P
L
Y
A
L
A
T
W
---
R
R
------
G
Q
-
G
L
E
A
A
L
K
Y
F
L
L
G
A
L
A
A
A
F
F
L
Y
G
A
-
A
L
----
F
Y
G
A
T
G
--
S
--
L
V
L
-
G
A
P
G
--------------
E
G
P
L
Y
A
L
A
L
G
L
L
L
V
G
L
G
F
-
K
A
A
L
A
P
F
H
F
W
T
P
D
V
Y
Q
G
-
S
P
-
T
-
P
V
V
L
F
M
A
--
T
-
S
V
K
A
A
--
A
F
A
A
L
L
R
V
A
-
A
P
------------------
P
E
--
A
L
A
-
L
L
V
A
L
S
V
V
V
G
N
L
A
A
L
A
Q
K
E
A
K
R
L
L
A
Y
S
S
I
-
A
H
A
G
Y
M
A
L
A
L
Y
T
--------
G
-----
N
---
A
Q
A
L
G
F
Y
L
L
T
Y
V
L
A
T
G
L
A
F
A
V
L
S
Q
I
S
--
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
66.25
18%
-137
- C3 -
3RKO
2
?
N:
[62-355]
----------------------------------------------------------------------------------------
D
V
T
P
L
M
R
------------
V
D
G
F
A
M
L
Y
T
G
L
V
L
L
A
S
L
A
T
C
T
F
A
Y
P
W
L
E
G
Y
N
D
N
K
D
E
F
Y
L
L
V
L
I
A
-
A
L
G
G
I
L
L
A
N
A
N
H
L
A
S
L
F
L
G
I
E
L
I
------
S
L
P
L
F
G
L
V
G
Y
---
A
F
R
Q
----
K
R
-
S
L
E
A
S
I
K
Y
T
I
L
S
A
A
A
S
S
F
L
L
F
G
M
-
A
L
----
V
Y
A
Q
S
G
--
D
--
L
S
F
-
V
A
L
G
K
-------------
N
E
P
L
L
L
A
G
F
G
L
M
I
V
G
L
G
F
-
K
L
S
L
V
P
F
H
L
W
T
P
D
V
Y
Q
G
-
A
P
-
A
-
P
V
S
T
F
L
A
T
---
A
S
K
I
A
--
I
F
G
V
V
M
R
L
F
-
L
Y
-
A
-
P
-----
V
GD
S
E--
A
I
R
V
--
V
L
A
-
I
I
A
F
A
S
I
I
F
G
N
L
M
A
L
S
Q
T
N
I
K
R
L
L
G
Y
S
S
I
-
S
H
L
G
Y
L
L
V
A
L
I
A
--------
L
QTGEM
S
---
M
E
A
V
G
V
Y
L
A
G
Y
L
F
S
S
L
G
A
F
G
V
V
S
L
M
S
--
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
61.63
17%
-128
- C2 -
4JP0
-
?
A:
[2-381]
------------
L
D
T
N
K
V
Y
E
-
I
S
N
H
A
N
G
L
Y
A
A
--
T
--
Y
L
S
L
--
D
----------------
D
S
G
V
S
L
M
N
K
N
D
--
D
--------
D
---
I
D
D
---------------------------------------------------
Y
N
L
K
W
F
L
F
P
I
D
-
D
D
-----------
Q
Y
I
I
T
S
Y
A
A
N
------
N
C
------------
K
V
W
----
N
V
-
N
N
------
D
K
I
N
V
S
T
Y
S
S
T
N
S
I
Q
-
K
W
----
Q
I
K
A
N
G
--
S
------
S
Y
V
I
Q
S
D
N
-
G
K
V
L
T
---
A
G
T
G
Q
A
L
G
L
-----
I
R
L
T
D
-
E
S
S
N
N
P
N
Q
Q
W
N
L
T
S
V
-
Q
-
T
I
-
Q
L
P
Q
K
P
I
I
D
T
-
K
-
L
K
D
------------
Y
-
P
K
-
Y
-
S
-----
G
--
N
---
I
D
N
--------------------------------
G
T
S
P
-
Q
L
M
G
W
T
L
V
P
C
I
M
VNDPNID
K
N
-----
T
---
Q
I
K
T
T
P
Y
Y
I
L
K
K
Y
Q
Y
W
Q
R
A
V
G
S
N
V
A
L
--
R
P
H
-
E
K
K
S
-
Y
T
Y
E
W
G
TEIDQ
K
T
T
I
I
N
T
L
G
F
Q
I
N
I
D
S
G
M
K
F
D
I
P
E
V
G
G
G
T
D
E
I
K
T
Q
L
N
E
E
L
K
I
E
Y
S
H
E
T
K
I
M
E
K
Y
Q
E
Q
S
E
-----
I
D
N
P
T
D
Q
S
M
N
S
I
G
F
L
T
I
T
S
L
E
L
Y
R
Y
N
G
S
E
I
R
I
M
Q
I
Q
T
S
-------------------
D
N
D
T
-
Y
N
V
T
S
Y
---------------
P
N
H
Q
Q
A
L
L
L
L
T
N
H
-----
S
Y
E
E
V
E
E
I
T
N
I
P
K
S
T
L
I
K
L
-
K
K
H
-------------------------------------------------------------------------------------------
22
Fugue
49.07
12%
-129
- C3 -
1EMS
7
NFT1_CAEEL
A:
[10-440]
---------
M
A
T
G
R
H
F
I
A
V
C
-
Q
M
T
S
D
N
D
L
E
K
N
--
F
--
Q
A
A
K
--
N
-
M
I
E
R
A
G
E
K
K
C
E
M
V
F
L
P
E
C
F
D
F
I
G
L
N
K
--
N
--------
E
---
Q
I
D
L
A
M
A
T
D
------------
C
E
Y
M
E
K
Y
R
E
L
A
R
K
H
-
N
I
W
L
S
L
G
G
L
H
H
K
D
P
S
-
D
A
A
H
P
W
N
T
H
L
I
I
D
S
D
G
V
T
R
A
E
Y
N
K
L
H
L
F
D
L
E
I
P
G
K
V
R
------
L
M
E
S
E
F
S
K
A
G
---
T
E
M
I
----
P
P
-
V
D
T
P
I
G
R
L
G
--
L
S
I
C
Y
D
V
R
F
P
E
L
-
S
L
----
W
N
R
K
R
G
--
A
--
Q
L
L
-
S
F
P
S
A
--
F
-
T
L
N
T
G
---
L
A
H
W
E
T
L
L
R
A
R
A
I
E
N
Q
C
Y
V
-
V
A
A
--------
A
Q
T
G
-
A
-
H
N
-
P
-
K
R
Q
S
Y
G
H
S
-
M
-
V
V
D
P
W
--
G
A
V
-
V
A
Q
--------------------------------
C
S
E
R
V
D
M
C
F
A
E
I
D
L
S
Y
V
D
T
L
R
E
M
Q
P
V
F
S
-
H
R
---------------------------------
R
S
D
L
Y
T
L
H
I
N
E
K
S
S
E
T
G
G
L
K
F
--
A
R
F
-
N
I
P
A
-
D
H
------------
I
F
Y
S
T
P
H
S
F
V
F
V
N
-----
L
K
P
V
T
D
G
-
H
V
L
V
S
P
------------
K
R
V
V
P
R
L
T
D
L
T
D
-----
A
E
T
A
D
L
F
I
V
A
K
K
V
Q
A
M
L
E
K
H
H
N
V
T
S
T
T
I
C
V
Q
D
-------------------------
G
K
D
A
-
G
Q
----------------------
T
V
P
H
V
H
I
H
I
L
-----
P
R
R
A
G
D
F
-
P
R
S
N
E
Q
M
A
E
E
A
-
V
V
Y
R
N
L
M---------------------------------------------------------------------------------------
19
Fugue
28.80
16%
192
- C3 -
3G9R
7
GCN4_YEAST
A:
[1-42]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
-
D
K
W
A
S
L
---------------
W
N
W
F
N
I
T
N
W
L
W
Y
I
-----
K
I
E
E
L
K
S
K
I
K
R
I
E
N
E
I
K
R
I
-
K
K
--------------------------------------------------------------------------------------------
10
HHSearch
28.05
8%
-38
- C3 -
4HE8
-
NQO11_THET8
K:
[8-88]
---------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
F
-
A
L
G
V
Y
G
V
L
T
R
R
T
A
I
L
V
F
L
S
I
E
L
M
------
L
N
A
A
N
L
S
L
V
G
---
F
A
R
A
----
Y
G
L
D
G
Q
V
A
A
L
M
V
I
A
V
A
A
A
E
V
A
V
G
L
G
L
I
V
A
----
I
F
R
H
R
E
--
S
--
T
A
V
-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
26.09
8%
53
- C3 -
3RKO
-
NUOK_ECOBD
K:
[11-49]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
A
I
L
F
-
V
L
G
L
T
G
L
V
I
R
R
N
L
L
F
M
L
I
G
L
E
I
M
------
I
N
A
S
A
L
A
F
V
V
---
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
22.41
31%
799
* C3 *
2O5G
-
B:
[4-19]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---
R
R
K
W
----
Q
K
-
T
G
H
A
V
R
A
I
G
R
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------