@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu27860: (2016-07-13 )
MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEGIFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLIQRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGIMIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPPDTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTLSNESVEECCYVNS
Atome Classification :
(45 SA)
---------.........10........-20----.........30..-----.......40........50.....-...--60---.........70........------80........90........100.......110.......120...--....130.......140.......150.......160.......170.......180.......190.......200.......210.......220........230-.---..---.---.....240.......250.......260.......270.......280.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------M
N
H
L
Q
L
K
K
L
L
N
H
F
F
L
E
DIG-T-----GDLTSQSIFG-EQ-----SC
E
A
E
I
V
A
KSEGIF
A
G
A
A
I
I
K
E
G
F
-
S
L
L
--
D
----
E
N
V
Q
S
I
L
HKKDGDMLHK
G
E
------
V
I
A
E
LHG
P
A
A
A
L
LSG
E
R
V
V
L
N
L
I
Q
R
L
S
G
I
A
T
M
T
R
E
A
V
R
CLDDE
Q
I
K
--
I
CDTRKTT
P
G
L
R
M
L
E
K
Y
A
VRAGGGYNHRFGLYD
G
I
M
I
KDN
H
I
A
A
C
G
S
I
L
E
A
C
K
K
A
R
Q
AAG
H
M
V
N
I
E
V
E
IE
T
E
E
Q
L
R
E
A
I
AAGA
D
V
I
M
FDNCP
P
D
T
V
-
R
H
F
A
KLTPA---N---
I
K
---T---EASG
G
I
T
L
ESLPAFKGTG
V
N
Y
I
S
L
G
F
L
THSV
K
S
L
D
I
S
M
D
V
T
LSNE
S
V
E
E
CCYVNS
3
PsiBlast_PDB
91.28
37%
-137
- C7 -
3TQV
2
?
A:
[19-286]
--------------
V
T
R
L
V
R
E
S
L
A
E
D
I
A
-
T
-----
G
D
I
T
A
Q
-
L
A
E
-
D
I
-----
D
T
T
A
F
C
I
T
R
E
E
M
I
L
C
G
Q
D
F
A
N
E
V
I
-
N
Q
L
--
D
----
K
N
I
Q
I
T
W
L
Y
S
D
A
Q
K
V
P
A
N
A
------
R
I
F
E
L
K
G
N
V
R
S
I
L
T
A
E
R
T
I
L
N
F
I
Q
M
L
S
G
T
A
T
V
T
N
K
L
V
K
L
I
S
Q
Y
K
T
K
--
L
L
D
T
R
K
T
I
P
G
F
R
L
A
Q
K
Y
A
V
R
C
G
G
G
F
N
H
R
I
G
L
F
D
A
Y
L
I
K
E
N
H
I
----
G
I
A
K
A
V
T
K
A
K
K
L
D
S
N
K
V
-
V
E
V
E
V
T
N
L
D
E
L
N
Q
A
I
A
A
K
A
D
I
V
M
L
D
N
F
S
G
E
D
I
-
D
I
A
V
S
I
A
R
G
---
K
---
V
A
---
L
---
E
V
S
G
N
I
D
R
N
S
I
V
A
I
A
K
T
G
V
D
F
I
S
V
G
A
I
T
K
H
I
K
A
I
D
L
S
L
Q
V
Q
--------------
81
PsiBlast_CBE
86.07
36%
-46
- C7 -
2JBM
2
NADC_HUMAN
F:
[12-287]
---------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
--
P
-----
G
L
N
Y
A
A
L
V
S
G
-
A
G
-----
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
-
T
Q
L
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
-
H
P
T
A
T
V
L
K
A
QFP
S
---
V
A
---
V
---
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
96
HHSearch
85.55
37%
-76
- C7 -
3TQV
2
?
A:
[16-286]
-----------
N
D
I
V
T
R
L
V
R
E
S
L
A
E
D
I
A
-
T
-----
G
D
I
T
A
Q
L
A
-
E
-
D
I
-----
D
T
T
A
F
C
I
T
R
E
E
M
I
L
C
G
Q
D
F
A
N
E
V
I
-
N
Q
L
--
D
----
K
N
I
Q
I
T
W
L
Y
S
D
A
Q
K
V
P
A
N
A
------
R
I
F
E
L
K
G
N
V
R
S
I
L
T
A
E
R
T
I
L
N
F
I
Q
M
L
S
G
T
A
T
V
T
N
K
L
V
K
L
I
S
Q
Y
K
T
K
--
L
L
D
T
R
K
T
I
P
G
F
R
L
A
Q
K
Y
A
V
R
C
G
G
G
F
N
H
R
I
G
L
F
D
A
Y
L
I
K
E
N
H
I
----
G
I
A
K
A
V
T
K
A
K
K
L
D
S
N
-
K
V
V
E
V
E
V
T
N
L
D
E
L
N
Q
A
I
A
A
K
A
D
I
V
M
L
D
N
F
S
G
E
D
I
D
I
A
V
S
I
A
R
G
----
K
---
V
A
---
L
---
E
V
S
G
N
I
D
R
N
S
I
V
A
I
A
K
T
G
V
D
F
I
S
V
G
A
I
T
K
H
I
K
A
I
D
L
S
L
Q
V
Q
--------------
76
PsiBlast_CBE
85.54
36%
-44
- C7 -
2JBM
2
NADC_HUMAN
K:
[12-287]
---------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
--
P
-----
G
L
N
Y
A
A
L
V
S
G
-
A
G
-----
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
-
T
Q
L
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
-
H
P
T
A
T
V
L
K
A
QFP
S
---
V
A
---
V
---
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
82
PsiBlast_CBE
85.40
36%
-44
- C7 -
2JBM
2
NADC_HUMAN
E:
[12-287]
---------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
--
P
-----
G
L
N
Y
A
A
L
V
S
G
-
A
G
-----
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
-
T
Q
L
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
-
H
P
T
A
T
V
L
K
A
QFP
S
---
V
A
---
V
---
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
78
PsiBlast_CBE
85.40
36%
-46
- C7 -
2JBM
2
NADC_HUMAN
I:
[12-287]
---------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
--
P
-----
G
L
N
Y
A
A
L
V
S
G
-
A
G
-----
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
-
T
Q
L
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
-
H
P
T
A
T
V
L
K
A
QFP
S
---
V
A
---
V
---
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
73
PsiBlast_CBE
85.15
36%
-46
- C7 -
5AYY
2
NADC_HUMAN
C:
[10-285]
---------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
--
P
-----
G
L
N
Y
A
A
L
V
S
G
-
A
G
-----
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
-
T
Q
L
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
-
H
P
T
A
T
V
L
K
A
QFP
S
---
V
A
---
V
---
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
60
PsiBlast_CBE
85.13
36%
-45
- C7 -
5AYZ
1
NADC_HUMAN
H:
[10-285]
---------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
--
P
-----
G
L
N
Y
A
A
L
V
S
G
-
A
G
-----
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
-
T
Q
L
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
-
H
P
T
A
T
V
L
K
A
QFP
S
---
V
A
---
V
---
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
62
PsiBlast_CBE
84.98
36%
-42
- C7 -
5AYZ
1
NADC_HUMAN
F:
[10-285]
---------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
--
P
-----
G
L
N
Y
A
A
L
V
S
G
-
A
G
-----
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
-
T
Q
L
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
-
H
P
T
A
T
V
L
K
A
QFP
S
---
V
A
---
V
---
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
69
PsiBlast_CBE
84.97
36%
-40
- C7 -
5AYY
2
NADC_HUMAN
G:
[10-285]
---------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
--
P
-----
G
L
N
Y
A
A
L
V
S
G
-
A
G
-----
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
-
T
Q
L
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
-
H
P
T
A
T
V
L
K
A
QFP
S
---
V
A
---
V
---
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
17
PsiBlast_PDB
84.96
36%
-46
- C7 -
5AYZ
1
NADC_HUMAN
A:
[10-285]
---------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
--
P
-----
G
L
N
Y
A
A
L
V
S
G
-
A
G
-----
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
-
T
Q
L
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
T
G
H
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
-
H
P
T
A
T
V
L
K
A
Q
FP
S
---
V
A
---
V
---
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
18
PsiBlast_PDB
84.92
36%
-44
- C7 -
2JBM
2
NADC_HUMAN
A:
[12-287]
---------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
--
P
-----
G
L
N
Y
A
A
L
V
S
G
-
A
G
-----
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
-
T
Q
L
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
T
G
H
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
-
H
P
T
A
T
V
L
K
A
Q
F
P
S
---
V
A
---
V
---
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
59
PsiBlast_CBE
84.88
36%
-42
- C7 -
5AYZ
1
NADC_HUMAN
I:
[10-285]
---------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
--
P
-----
G
L
N
Y
A
A
L
V
S
G
-
A
G
-----
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
-
T
Q
L
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
-
H
P
T
A
T
V
L
K
A
QFP
S
---
V
A
---
V
---
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
61
PsiBlast_CBE
84.86
36%
-46
- C7 -
5AYZ
1
NADC_HUMAN
G:
[10-285]
---------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
--
P
-----
G
L
N
Y
A
A
L
V
S
G
-
A
G
-----
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
-
T
Q
L
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
-
H
P
T
A
T
V
L
K
A
QFP
S
---
V
A
---
V
---
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
83
PsiBlast_CBE
84.74
36%
-44
- C7 -
2JBM
2
NADC_HUMAN
D:
[12-287]
---------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
--
P
-----
G
L
N
Y
A
A
L
V
S
G
-
A
G
-----
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
-
T
Q
L
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
-
H
P
T
A
T
V
L
K
A
QFP
S
---
V
A
---
V
---
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
63
PsiBlast_CBE
84.57
36%
-44
- C7 -
5AYZ
1
NADC_HUMAN
E:
[10-285]
---------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
--
P
-----
G
L
N
Y
A
A
L
V
S
G
-
A
G
-----
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
-
T
Q
L
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
-
H
P
T
A
T
V
L
K
A
QFP
S
---
V
A
---
V
---
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
97
HHSearch
84.52
35%
-82
- C7 -
2B7N
2
NADC_HELPY
A:
[2-272]
-------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
D
L
F
E
R
V
L
E
K
-
D
F
-----
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
L
L
-
E
M
T
--------
G
I
E
C
V
Q
T
I
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
H
YP-
F
---
V
L
---
L
---
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
---------------
57
PsiBlast_CBE
84.46
36%
-47
- C7 -
5AYZ
1
NADC_HUMAN
K:
[10-285]
---------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
--
P
-----
G
L
N
Y
A
A
L
V
S
G
-
A
G
-----
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
-
T
Q
L
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
-
H
P
T
A
T
V
L
K
A
QFP
S
---
V
A
---
V
---
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
56
PsiBlast_CBE
84.38
36%
-40
- C7 -
5AYZ
1
NADC_HUMAN
L:
[10-285]
---------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
--
P
-----
G
L
N
Y
A
A
L
V
S
G
-
A
G
-----
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
-
T
Q
L
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
-
H
P
T
A
T
V
L
K
A
QFP
S
---
V
A
---
V
---
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
67
PsiBlast_CBE
84.36
36%
-46
- C7 -
5AYY
2
NADC_HUMAN
I:
[10-285]
---------
L
P
P
V
T
L
A
A
L
V
D
S
W
L
R
E
D
C
--
P
-----
G
L
N
Y
A
A
L
V
S
G
-
A
G
-----
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
I
F
-
T
Q
L
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
I
A
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
T
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
D
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
-
H
P
T
A
T
V
L
K
A
QFP
S
---
V
A
---
V
---
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
95
HHSearch
83.09
41%
-3
- C7 -
1QAP
2
NADC_SALTY
A:
[20-296]
------------
L
D
I
P
A
A
V
A
Q
A
L
R
E
D
L
G
-
G
EVDAG
N
D
I
T
A
Q
L
L
-
P
A
D
T
-----
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
K
R
W
V
E
E
V
F
-
I
Q
L
--
A
G---
D
D
V
R
L
T
W
H
V
D
D
G
D
A
I
H
A
N
Q
------
T
V
F
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
V
A
S
E
V
R
R
Y
V
G
L
L
A
G
T
Q
T
Q
--
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
H
P
D
-
V
P
V
E
V
E
V
E
N
L
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
T
D
Q
M
R
E
A
V
K
R
V
N
G
----
Q
---
A
R
---
L
---
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
R
F
C
--------------
113
Fugue
81.63
40%
6
- C7 -
1QAP
2
NADC_SALTY
A:
[8-296]
DD
R
R
D
A
L
L
E
R
I
N
L
D
I
P
A
A
V
A
Q
A
L
R
E
D
L
G
-
G
-----
E
V
D
A
G
N
D
I
T
A
-
Q
L
LPADT
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
K
R
W
V
E
E
V
F
-
I
Q
L
AG-----
D
D
V
R
L
T
W
H
V
D
D
G
D
A
I
H
A
N
Q
------
T
V
F
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
V
A
S
E
V
R
R
Y
V
G
L
L
A
G
T
Q
T
Q
--
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
H
P
D
V
-
P
V
E
V
E
V
E
N
L
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
T
D
Q
M
-
R
E
A
V
K
R
V
N
-G--
Q
---
A
R
---
L
---
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
R
F
C
--------------
22
PsiBlast_CBE
77.77
35%
6
- C7 -
3L0G
2
?
D:
[24-296]
------------
I
S
F
S
E
I
I
H
N
A
L
K
E
D
L
G
D
K
-----
G
D
I
T
T
N
S
I
L
I
-
N
E
-----
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
E
V
F
-
N
M
N
--
K
----
E
H
V
K
Y
E
I
H
K
K
D
G
D
I
T
G
K
N
S
------
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
T
K
V
K
--
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
K
N
E
Y
-
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
I
S
E
I
-
K
K
A
V
D
I
V
N
G
---
K
---
S
V
---
L
---
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
E
Y
-------------
23
PsiBlast_CBE
77.75
35%
7
- C7 -
3L0G
2
?
C:
[24-295]
------------
I
S
F
S
E
I
I
H
N
A
L
K
E
D
L
G
D
K
-----
G
D
I
T
T
N
S
I
L
I
-
N
E
-----
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
E
V
F
-
N
M
N
--
K
----
E
H
V
K
Y
E
I
H
K
K
D
G
D
I
T
G
K
N
S
------
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
T
K
V
K
--
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
K
N
E
Y
-
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
I
S
E
I
-
K
K
A
V
D
I
V
N
G
---
K
---
S
V
---
L
---
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
E
--------------
94
HHSearch
77.56
36%
-9
- C7 -
3L0G
2
?
A:
[24-295]
------------
I
S
F
S
E
I
I
H
N
A
L
K
E
D
L
G
D
K
-----
G
D
I
T
T
N
S
I
L
I
-
N
E
-----
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
E
V
F
-
N
M
N
--
K
----
E
H
V
K
Y
E
I
H
K
K
D
G
D
I
T
G
K
N
S
------
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
T
K
V
K
--
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
K
N
-
E
Y
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
I
S
E
I
K
K
A
V
D
I
V
N
G
----
K
---
S
V
---
L
---
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
E
--------------
19
PsiBlast_PDB
77.51
38%
-39
- C7 -
4I9A
1
?
A:
[36-285]
------------------------------------------
V
T
G
-
A
A
-----
P
S
Q
A
V
L
W
A
K
S
P
G
I
L
A
G
R
P
F
F
D
A
I
F
-
A
Q
V
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
K
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
M
L
A
R
C
S
G
V
A
S
A
A
A
T
A
V
E
T
A
R
G
T
G
W
A
G
H
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
T
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
K
Q
A
V
Q
G
A
R
R
A
A
N
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
L
E
A
A
E
A
G
A
D
L
V
L
L
D
N
F
R
P
E
E
L
-
H
P
T
A
A
A
L
K
A
---
Q
---
F
P
---
T
V
G
V
E
A
S
G
G
V
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
L
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
5
PsiBlast_PDB
77.33
35%
10
- C7 -
3L0G
2
?
A:
[24-295]
------------
I
S
F
S
E
I
I
H
N
A
L
K
E
D
L
G
D
K
-----
G
D
I
T
T
N
S
I
L
I
-
N
E
-----
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
E
V
F
-
N
M
N
--
K
----
E
H
V
K
Y
E
I
H
K
K
D
G
D
I
T
G
K
N
S
------
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
T
K
V
K
--
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
K
N
E
Y
-
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
I
S
E
I
-
K
K
A
V
D
I
V
N
G
---
K
---
S
V
---
L
---
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
E
--------------
24
PsiBlast_CBE
77.01
35%
10
- C7 -
3L0G
2
?
B:
[24-296]
------------
I
S
F
S
E
I
I
H
N
A
L
K
E
D
L
G
D
K
-----
G
D
I
T
T
N
S
I
L
I
-
N
E
-----
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
E
V
F
-
N
M
N
--
K
----
E
H
V
K
Y
E
I
H
K
K
D
G
D
I
T
G
K
N
S
------
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
T
K
V
K
--
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
K
N
E
Y
-
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
I
S
E
I
-
K
K
A
V
D
I
V
N
G
---
K
---
S
V
---
L
---
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
E
Y
-------------
86
PsiBlast_CBE
76.95
38%
-33
- C7 -
4I9A
1
?
B:
[36-285]
------------------------------------------
V
T
G
-
A
A
-----
P
S
Q
A
V
L
W
A
K
S
P
G
I
L
A
G
R
P
F
F
D
A
I
F
-
A
Q
V
--
N
----
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
------
K
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
M
L
A
R
C
S
G
V
A
S
A
A
A
T
A
V
E
T
A
R
G
T
G
W
A
GH
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
T
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
K
Q
A
V
Q
G
A
R
R
A
A
N
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
L
E
A
A
E
A
G
A
D
L
V
L
L
D
N
F
R
P
E
E
L
-
H
P
T
A
A
A
L
K
A
---
Q
---
F
P
---
T
VGV
E
A
S
G
G
V
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
L
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
---------------
47
PsiBlast_CBE
76.84
35%
2
- C7 -
2B7P
2
NADC_HELPY
C:
[1-272]
------------
M
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
D
L
F
E
R
V
L
E
K
-
D
F
-----
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
---
K
Y
A
L
-
E
L
L
--
E
MTGI
E
C
V
Q
T
I
---
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
-
K
E
I
A
A
Y
R
D
A
---
H
YPF
V
L
---
L
---
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
---------------
10
PsiBlast_PDB
76.67
35%
3
- C7 -
2B7N
2
NADC_HELPY
A:
[1-272]
------------
M
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
D
L
F
E
R
V
L
E
K
-
D
F
-----
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
---
K
Y
A
L
-
E
L
L
--
E
M
T
GI
E
C
V
Q
T
I
---
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
-
K
E
I
A
A
Y
R
D
A
---
H
YPF
V
L
---
L
---
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
---------------
50
PsiBlast_CBE
75.88
35%
4
- C7 -
2B7N
2
NADC_HELPY
B:
[1-272]
------------
M
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
D
L
F
E
R
V
L
E
K
-
D
F
-----
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
---
K
Y
A
L
-
E
L
L
--
E
MTGI
E
C
V
Q
T
I
---
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
-
K
E
I
A
A
Y
R
D
A
---
H
YPF
V
L
---
L
---
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
---------------
2
PsiBlast_PDB
75.62
42%
3
- C7 -
1QAP
2
NADC_SALTY
A:
[43-293]
------------------------------------
D
I
T
A
Q
L
L
P
A
-
D
T
-----
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
K
R
W
V
E
E
V
F
I
Q
L
A
--
G
----
D
D
V
R
L
T
W
H
V
D
D
G
D
A
I
H
A
N
Q
------
T
V
F
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
V
A
S
E
V
R
R
Y
V
G
L
L
A
G
T
Q
T
Q
--
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
H
P
D
-
V
P
V
E
V
E
V
E
N
L
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
T
D
Q
M
-
R
E
A
V
K
R
V
N
G
---
Q
---
A
R
---
L
---
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
-----------------
49
PsiBlast_CBE
75.15
35%
2
- C7 -
2B7N
2
NADC_HELPY
C:
[1-272]
------------
M
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
D
L
F
E
R
V
L
E
K
-
D
F
-----
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
---
K
Y
A
L
-
E
L
L
--
E
MTGI
E
C
V
Q
T
I
---
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
-
K
E
I
A
A
Y
R
D
A
---
H
YPF
V
L
---
L
---
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
---------------
48
PsiBlast_CBE
75.00
35%
4
- C7 -
2B7P
2
NADC_HELPY
B:
[1-272]
------------
M
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
D
L
F
E
R
V
L
E
K
-
D
F
-----
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
---
K
Y
A
L
-
E
L
L
--
E
MTGI
E
C
V
Q
T
I
---
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
-
K
E
I
A
A
Y
R
D
A
---
H
YPF
V
L
---
L
---
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
---------------
21
PsiBlast_CBE
75.00
42%
6
- C7 -
1QAP
1
NADC_SALTY
B:
[43-293]
------------------------------------
D
I
T
A
Q
L
L
P
A
-
D
T
-----
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
K
R
W
V
E
E
V
F
I
Q
L
A
--
G
----
D
D
V
R
L
T
W
H
V
D
D
G
D
A
I
H
A
N
Q
------
T
V
F
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
V
A
S
E
V
R
R
Y
V
G
L
L
A
G
T
Q
T
Q
--
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
H
P
D
-
V
P
V
E
V
E
V
E
N
L
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
T
D
Q
M
-
R
E
A
V
K
R
V
N
G
---
Q
---
A
R
---
L
---
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
-----------------
11
PsiBlast_PDB
74.66
35%
3
- C7 -
2B7P
2
NADC_HELPY
A:
[1-272]
------------
M
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
D
L
F
E
R
V
L
E
K
-
D
F
-----
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
---
K
Y
A
L
-
E
L
L
--
E
M
T
GI
E
C
V
Q
T
I
---
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
-
K
E
I
A
A
Y
R
D
A
---
H
YPF
V
L
---
L
---
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
---------------
46
PsiBlast_CBE
74.39
35%
9
- C7 -
2B7Q
1
NADC_HELPY
B:
[1-272]
------------
M
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
D
L
F
E
R
V
L
E
K
-
D
F
-----
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
---
K
Y
A
L
-
E
L
L
--
E
MTGI
E
C
V
Q
T
I
---
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
-
K
E
I
A
A
Y
R
D
A
---
H
YPF
V
L
---
L
---
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
---------------
45
PsiBlast_CBE
74.15
35%
11
- C7 -
2B7Q
1
NADC_HELPY
C:
[1-272]
------------
M
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
D
L
F
E
R
V
L
E
K
-
D
F
-----
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
---
K
Y
A
L
-
E
L
L
--
E
MTGI
E
C
V
Q
T
I
---
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
-
K
E
I
A
A
Y
R
D
A
---
H
YPF
V
L
---
L
---
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
---------------
12
PsiBlast_PDB
73.23
35%
2
- C7 -
2B7Q
1
NADC_HELPY
A:
[1-272]
------------
M
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
D
L
F
E
R
V
L
E
K
-
D
F
-----
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
---
K
Y
A
L
-
E
L
L
--
E
M
T
GI
E
C
V
Q
T
I
---
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
-
K
E
I
A
A
Y
R
D
A
---
H
YPF
V
L
---
L
---
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
---------------
87
PsiBlast_CBE
73.11
33%
-23
- C7 -
3C2V
2
NADC_YEAST
A:
[13-290]
--------------
W
R
Q
D
V
T
N
W
L
S
E
D
V
P
-
S
-----
F
D
F
G
G
Y
-
V
V
G
-
S
D
-----
L
K
E
A
N
L
Y
C
K
Q
D
G
M
L
C
G
V
P
F
A
Q
E
V
F
-
N
Q
C
--
E
----
L
Q
V
E
W
L
F
--
K
E
G
S
F
L
E
P
S
K
NDSGKI
V
V
A
K
I
T
G
P
A
K
N
I
L
L
A
E
R
T
A
L
N
I
L
S
R
S
S
G
I
A
T
A
S
H
K
I
I
S
L
A
R
S
T
G
Y
K
G
T
I
A
G
T
R
K
T
T
P
G
L
R
R
L
E
K
Y
S
M
L
V
G
G
C
D
T
H
R
Y
D
L
S
S
M
V
M
L
K
D
N
H
I
W
A
T
G
S
I
T
N
A
V
K
N
A
R
A
V
C
G
F
A
V
K
I
E
V
E
C
L
S
E
D
E
A
T
E
A
I
E
A
G
A
D
V
I
M
L
D
N
-------------------------H
F
L
L
---
E
C
S
G
G
L
N
L
D
N
L
--
Y
L
C
D
D
I
D
I
Y
S
T
S
S
I
H
Q
G
T
P
V
I
D
F
S
L
-----------------
91
PsiBlast_CBE
71.28
33%
-9
- C7 -
3C2R
2
NADC_YEAST
A:
[14-291]
--------------
W
R
Q
D
V
T
N
W
L
S
E
D
V
P
-
S
-----
F
D
F
G
G
Y
-
V
V
G
-
S
D
-----
L
K
E
A
N
L
Y
C
K
Q
D
G
M
L
C
G
V
P
F
A
Q
E
V
F
-
N
Q
C
--
E
----
L
Q
V
E
W
L
F
--
K
E
G
S
F
L
E
P
S
K
NDSGKI
V
V
A
K
I
T
G
P
A
K
N
I
L
L
A
E
R
T
A
L
N
I
L
S
R
S
S
G
I
A
T
A
S
H
K
I
I
S
L
A
R
S
T
G
Y
K
G
T
I
A
G
T
R
K
T
T
P
G
L
R
R
L
E
K
Y
S
M
L
V
G
G
C
D
T
H
R
Y
D
L
S
S
M
V
M
L
K
D
N
H
I
W
A
T
G
S
I
T
N
A
V
K
N
A
R
A
V
C
G
F
A
V
K
I
E
V
E
C
L
S
E
D
E
A
T
E
A
I
E
A
G
A
D
V
I
M
L
D
N
-------------------------H
F
L
L
---
E
C
S
G
G
L
N
L
------
L
C
D
D
I
D
I
Y
S
T
S
S
I
H
Q
G
T
P
V
I
D
F
S
L
-----------------
89
PsiBlast_CBE
71.12
33%
-9
- C7 -
3C2F
1
NADC_YEAST
A:
[13-290]
--------------
W
R
Q
D
V
T
N
W
L
S
E
D
V
P
-
S
-----
F
D
F
G
G
Y
-
V
V
G
-
S
D
-----
L
K
E
A
N
L
Y
C
K
Q
D
G
M
L
C
G
V
P
F
A
Q
E
V
F
-
N
Q
C
--
E
----
L
Q
V
E
W
L
F
--
K
E
G
S
F
L
E
P
S
K
NDSGKI
V
V
A
K
I
T
G
P
A
K
N
I
L
L
A
E
R
T
A
L
N
I
L
S
R
S
S
G
I
A
T
A
S
H
K
I
I
S
L
A
R
S
T
G
Y
K
G
T
I
A
G
T
R
K
T
T
P
G
L
R
R
L
E
K
Y
S
M
L
V
G
G
C
D
T
H
R
Y
D
L
S
S
M
V
M
L
K
D
N
H
I
W
A
T
G
S
I
T
N
A
V
K
N
A
R
A
V
C
G
F
A
V
K
I
E
V
E
C
L
S
E
D
E
A
T
E
A
I
E
A
G
A
D
V
I
M
L
D
N
-------------------------H
F
L
L
---
E
C
S
G
G
L
N
L
------
L
C
D
D
I
D
I
Y
S
T
S
S
I
H
Q
G
T
P
V
I
D
F
S
L
-----------------
88
PsiBlast_CBE
70.81
33%
-22
- C7 -
3C2O
1
NADC_YEAST
A:
[13-290]
--------------
W
R
Q
D
V
T
N
W
L
S
E
D
V
P
-
S
-----
F
D
F
G
G
Y
-
V
V
G
-
S
D
-----
L
K
E
A
N
L
Y
C
K
Q
D
G
M
L
C
G
V
P
F
A
Q
E
V
F
-
N
Q
C
--
E
----
L
Q
V
E
W
L
F
--
K
E
G
S
F
L
E
P
S
K
NDSGKI
V
V
A
K
I
T
G
P
A
K
N
I
L
L
A
E
R
T
A
L
N
I
L
S
R
S
S
G
I
A
T
A
S
H
K
I
I
S
L
A
R
S
T
G
Y
K
G
T
I
A
G
T
R
K
T
T
P
G
L
R
R
L
E
K
Y
S
M
L
V
G
G
C
D
T
H
R
Y
D
L
S
S
M
V
M
L
K
D
N
H
I
W
A
T
G
S
I
T
N
A
V
K
N
A
R
A
V
C
G
F
A
V
K
I
E
V
E
C
L
S
E
D
E
A
T
E
A
I
E
A
G
A
D
V
I
M
L
D
N
-------------------------H
F
L
L
---
E
C
S
G
G
L
N
-------
L
C
D
D
I
D
I
Y
S
T
S
S
I
H
Q
G
T
P
V
I
D
F
S
L
-----------------
90
PsiBlast_CBE
70.12
33%
-16
- C7 -
3C2R
2
NADC_YEAST
B:
[14-291]
--------------
W
R
Q
D
V
T
N
W
L
S
E
D
V
P
-
S
-----
F
D
F
G
G
Y
-
V
V
G
-
S
D
-----
L
K
E
A
N
L
Y
C
K
Q
D
G
M
L
C
G
V
P
F
A
Q
E
V
F
-
N
Q
C
--
E
----
L
Q
V
E
W
L
F
--
K
E
G
S
F
L
E
P
S
K
NDSGKI
V
V
A
K
I
T
G
P
A
K
N
I
L
L
A
E
R
T
A
L
N
I
L
S
R
S
S
G
I
A
T
A
S
H
K
I
I
S
L
A
R
S
T
G
Y
K
GT
I
A
G
T
R
K
T
T
P
G
L
R
R
L
E
K
Y
S
M
L
V
G
G
C
D
T
H
R
Y
D
L
S
S
M
V
M
L
K
D
N
H
I
W
A
T
G
S
I
T
N
A
V
K
N
A
R
A
V
C
G
F
A
V
K
I
E
V
E
C
L
S
E
D
E
A
T
E
A
I
E
A
G
A
D
V
I
M
L
D
N
-------------------------HFL
L
---
E
C
S
G
G
L
N
L
------
L
C
D
D
I
D
I
Y
S
T
S
S
I
H
Q
G
T
P
V
I
D
F
S
L
-----------------