@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu30870: (2016-07-21 )
MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKLKNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHNIQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLCHVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYISDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEPSNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE
Atome Classification :
(22 SA)
.........10........20.-...--.------.-..30....-....-40.-.....-..50....---....60....-..-..70--...--..---....80........90........100.......110....---------...120.....-.-.130--..-.--.-----------...140---.........150.......160.......170-.......180....---.---..190....----...200........210.......220.-.-.....230.---......240.......250......-.260----.....-------.----.-.270.......280.......290.......300.......310....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
L
V
TG
A
A
G
F
I
G
S
H
L
C
E
E
L
L
K
-DKK--H------
N
-
V
I
GIDDFI-GPTP-
F
S
L
-
K
L
K
N
L
-
K
N
LL
P
E
K
R
---
F
T
F
I
K
E
N
L
L
T
-
A
D
-
L
A
S
---
L
L
E
--
G
V
---
D
V
I
F
H
L
AAIPGV
R
S
SWGNHFHPYAAH
N
I
Q
A
L
Q
R
L
L
E
A
C
R
EH---------S
I
Q
T
F
V
F
ASTS-S-VYGE--KQ-G--K-----------VSEN-----TSLSPLSPYGVTKL
T
G
E
K
L
C
H
V
Y
K
Q
SFG
I
P
I
V
-
I
L
R
F
F
T
VYGPRQRP---
D
---
M
A
F
H
R
L
I
K
Q
----
H
LQQ-KP
L
T
I
F
GDGQQSR
D
F
T
Y
I
S
D
C
V
K
-
G
-
I
T
A
V
LGKPH---LIGETVNIG
G
A
E
R
A
S
V
L
K
V
V
S
L
I
E
D
-ISG-----
R
K
A
T
L
-------
H
----F-SDKIAGEPSN
T
W
A
D
I
S
K
A
K
Q
L
LHYDP
A
T
S
L
KDG
L
T
N
E
I
A
Y
L
S
S
L
YQGE
4
PsiBlast_PDB
80.01
30%
-39
- C1 -
4GLL
3
UXS1_HUMAN
A:
[7-308]
-
R
I
L
I
T
G
G
A
G
F
V
G
S
H
L
T
D
K
L
M
M
-
D
G
---
H
------
E
-
V
T
V
V
D
N
F
-------
F
T
G
-
R
K
R
N
V
-
E
H
W
I
G
H
E
N
---
F
E
L
I
N
H
D
V
V
E
-
P
--------
L
Y
I
--
E
V
---
D
Q
I
Y
H
L
A
S
P
A
S
P
P
N
Y
M
Y
N
P
I
K
T
L
K
T
N
T
I
G
T
L
N
M
L
G
L
A
K
R
V
G
---------
A
--
R
L
L
L
A
S
T
S
-
E
-
V
Y
G
D
--
P
E
V
H
--
P
-----------
Q
S
E
D
YW
G
H
V
N
P
I
G
P
R
A
C
Y
D
E
G
K
R
V
A
E
T
M
C
Y
A
Y
M
K
Q
E
G
V
E
V
R
-
V
A
R
I
F
N
T
F
G
P
R
M
H
M
---
N
DG-
R
V
V
S
N
F
I
L
Q
----
A
L
Q
G
-
E
P
L
T
V
Y
G
S
G
S
Q
T
R
A
F
Q
Y
V
S
D
L
V
N
-
G
-
L
V
A
L
M
N
S
N
-----
V
S
S
P
V
N
L
G
N
P
E
E
H
T
I
L
E
F
A
Q
L
I
K
N
-
L
V
G
-----
S
G
S
E
I
-------
Q
----
F
-
L
S
E
A
Q
D
D
P
Q
K
R
K
P
D
I
K
K
A
K
L
M
L
G
W
E
P
V
V
P
L
E
E
G
L
N
K
A
I
H
Y
F
-------
5
PsiBlast_PDB
79.22
30%
-76
- C1 -
4M55
4
UXS1_HUMAN
A:
[6-307]
-
R
I
L
I
T
G
G
A
G
F
V
G
S
H
L
T
D
K
L
M
M
-
D
G
---
H
------
E
-
V
T
V
V
D
N
F
-------
F
T
G
-
R
K
R
N
V
-
E
H
W
I
G
H
E
N
---
F
E
L
I
N
H
D
V
V
E
-
P
--------
L
Y
I
--
E
V
---
D
Q
I
Y
H
L
A
S
P
-------
Y
N
P
I
K
T
L
K
T
N
T
I
G
T
L
N
M
L
G
L
A
K
R
V
G
---------
A
--
R
L
L
L
A
S
T
S
-
E
-
V
Y
G
------------------------------------------
K
H
V
A
E
T
M
C
Y
A
Y
M
K
Q
E
G
V
E
V
R
-
V
A
R
I
F
N
T
F
G
P
R
M
H
M
---
N
DG-
R
V
V
S
N
F
I
L
Q
----
A
L
Q
G
-
E
P
L
T
V
-----
Q
T
R
A
F
Q
Y
V
S
D
L
V
N
-
G
-
L
V
A
L
M
N
S
N
-----
V
S
S
P
V
N
L
G
N
P
E
E
H
T
I
L
E
F
A
Q
L
I
K
N
-
L
V
G
-----
S
G
S
E
I
-------
Q
----
F
-----------
R
K
P
D
I
K
K
A
K
L
M
L
G
W
E
P
V
V
P
L
E
E
G
L
N
K
A
I
H
Y
F
-------
3
PsiBlast_PDB
78.82
30%
-78
- C1 -
4LK3
6
UXS1_HUMAN
A:
[6-307]
-
R
I
L
I
T
G
G
A
G
F
V
G
S
H
L
T
D
K
L
M
M
-
D
G
---
H
------
E
-
V
T
V
V
D
N
F
-------
F
T
G
-
R
K
R
N
V
-
E
H
W
I
G
H
E
N
---
F
E
L
I
N
H
D
V
V
E
-
P
--------
L
Y
I
--
E
V
---
D
Q
I
Y
H
L
A
S
P
A
S
-----
Y
N
P
I
K
T
L
K
T
N
T
I
G
T
L
N
M
L
G
L
A
K
R
V
G
---------
A
--
R
L
L
L
A
S
T
S
-
E
-
V
Y
-----------------------------------------
E
G
K
A
V
A
E
T
M
C
Y
A
Y
M
K
Q
E
G
V
E
V
R
-
V
A
R
I
F
N
T
F
G
P
R
M
H
M
---
N
DG-
R
V
V
S
N
F
I
L
Q
----
A
L
Q
G
-
E
P
L
T
V
Y
----
Q
T
R
A
F
Q
Y
V
S
D
L
V
N
-
G
-
L
V
A
L
M
N
S
N
-----
V
S
S
P
V
N
L
G
N
P
E
E
H
T
I
L
E
F
A
Q
L
I
K
N
-
L
V
G
-----
S
G
S
E
I
-------
Q
----
F
-----------
R
K
P
D
I
K
K
A
K
L
M
L
G
W
E
P
V
V
P
L
E
E
G
L
N
K
A
I
H
Y
F
-------
72
HHSearch
77.93
28%
-17
- C1 -
1KEW
5
RMLB_SALTY
A:
[1-338]
M
K
I
L
I
T
G
G
A
G
F
I
G
S
A
V
V
R
H
I
I
K
-
N
-
T
--
Q
------
D
T
V
V
N
I
D
K
L
T
-
Y
A
G
---
N
L
-
E
S
L
S
---
D
I
S
E
S
N
R
---
Y
N
F
E
H
A
D
I
C
D
-
S
A
E
I
T
R
---
I
F
E
Q
Y
Q
P
---
D
A
V
M
H
L
A
A
E
S
H
V
D
R
S
I
T
G
-
P
A
A
F
I
E
T
N
I
V
G
T
Y
A
L
L
E
V
A
R
K
Y
W
S
A
LG
E
D
K
K
N
N
F
R
F
H
H
I
S
T
D
-
E
-
V
Y
G
D
--
L
P
-
H
--
P
DEVENS
V
T
L
P
L
F
T
E
T
-----
T
A
Y
A
P
S
S
P
Y
S
A
S
K
A
S
S
D
H
L
V
R
A
W
R
R
T
Y
G
L
P
T
I
-
V
T
N
C
S
N
N
Y
G
P
Y
H
F
P
---
E
---
K
L
I
P
L
V
I
L
N
----
A
L
E
G
-
K
P
L
P
I
Y
G
K
G
D
Q
I
R
D
W
L
Y
V
E
D
H
A
R
-
A
-
L
H
M
V
V
T
E
G
----
K
A
G
E
T
Y
N
I
G
G
H
N
E
K
K
N
L
D
V
V
F
T
I
C
D
-
L
L
D
-----
E
I
V
P
K
ATSYREQ
I
----
T
Y
V
A
D
R
P
G
H
D
R
R
Y
A
I
D
A
G
K
I
S
R
E
L
G
W
K
P
L
E
T
F
E
S
G
I
R
K
T
V
E
W
Y
L
A
N
T
---
67
HHSearch
77.65
27%
-58
- C1 -
3KO8
2
?
A:
[1-310]
M
R
I
V
V
T
G
G
A
G
F
I
G
S
H
L
V
D
K
L
V
E
-
L
-
G
--
Y
------
E
-
V
V
V
V
D
N
L
S
-
S
G
R
R
-----
E
--------
F
V
N
P
S
---
A
E
L
H
V
R
D
L
K
D
-
Y
S
-
W
G
A
---
G
-
I
--
K
G
---
D
V
V
F
H
F
A
A
N
P
E
V
R
L
S
T
T
E
-
P
I
V
H
F
N
E
N
V
V
A
T
F
N
V
L
E
W
A
R
Q
T
---------
G
V
R
T
V
V
F
A
S
S
S
-
T
-
V
Y
G
D
--
A
D
-
V
--
I
P----------
T
P
E
E
-----
E
P
Y
K
P
I
S
V
Y
G
A
A
K
A
A
G
E
V
M
C
A
T
Y
A
R
L
F
G
V
R
C
L
-
A
V
R
Y
A
N
V
V
G
P
R
L
R
H
---
G
----
V
I
Y
D
F
I
M
K
----
L
R
R
N
P
N
V
L
E
V
L
----
Q
R
K
S
Y
L
Y
V
R
D
A
V
E
-
A
-
T
L
A
A
W
K
K
F
E
E
M
D
A
P
F
L
A
L
N
V
G
N
V
D
A
V
R
V
L
D
I
A
Q
I
V
A
E
-
V
L
G
-----
L
R
P
-
E
-------
I
----
R
L
V
----
G
D
V
K
Y
M
T
L
A
V
T
K
L
M
K
L
T
G
W
R
P
T
M
T
S
A
E
A
V
K
K
T
A
E
D
L
A
K
E
L
---
1
PsiBlast_PDB
77.05
34%
-12
- C1 -
1SB8
2
?
A:
[31-341]
---
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
T
L
L
K
L
D
Q
K
-----------
V
V
G
L
D
N
F
---
A
T
G
-
H
Q
R
-
N
L
D
E
V
-
R
S
L
V
S
E
K
Q
W
S
N
F
K
F
I
Q
G
D
I
R
N
L
D
D
-
C
N
N
---
A
C
A
--
G
V
---
D
Y
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
N
D
P
I
T
S
N
A
T
-
N
I
D
G
F
L
N
M
L
I
A
A
R
D
A
---------
K
V
Q
S
F
T
Y
A
A
S
S
-
S
-
T
Y
G
D
--
H
P
-
G
LP
K
-----------
V
-
E
D
-----
T
I
G
K
P
L
S
P
Y
A
V
T
K
Y
V
N
E
L
Y
A
D
V
F
S
R
C
Y
G
F
S
T
I
-
G
L
R
Y
F
N
V
F
G
R
R
Q
D
P
---
N
---
G
A
Y
A
A
V
I
P
K
W
T
S
S
M
I
Q
G
-
D
D
V
Y
I
N
G
D
G
E
T
S
R
D
F
C
Y
I
E
N
T
V
Q
-
A
N
L
L
A
A
T
A
G
L
D
---
A
R
N
Q
V
Y
N
I
A
V
G
G
R
T
S
L
N
Q
L
F
F
A
L
R
D
G
L
A
E
-----
N
G
V
S
Y
-------
H
R
E
P
V
Y
-
R
D
F
R
E
G
D
V
R
H
S
L
A
D
I
S
K
A
A
K
L
L
G
Y
A
P
K
Y
D
V
S
A
G
V
A
-------------
6
PsiBlast_PDB
76.35
30%
-34
- C1 -
2B69
3
UXS1_HUMAN
A:
[29-330]
-
R
I
L
I
T
G
G
A
G
F
V
G
S
H
L
T
D
K
L
M
M
-
D
G
---
H
------
E
-
V
T
V
V
D
N
F
-------
F
T
G
-
R
K
R
N
V
-
E
H
W
I
G
H
E
N
---
F
E
L
I
N
H
D
V
V
E
-
P
--------
L
Y
I
--
E
V
---
D
Q
I
Y
H
L
A
S
P
A
S
P
P
N
Y
M
Y
N
P
I
K
T
L
K
T
N
T
I
G
T
L
N
M
L
G
L
A
K
R
V
G
---------
A
--
R
L
L
L
A
S
T
S
-
E
-
V
Y
G
D
--
P
E
V
H
--
P
-----------
Q
S
E
D
YW
G
H
V
N
P
I
G
P
R
A
C
Y
D
E
G
K
R
V
A
E
T
M
C
Y
A
Y
M
K
Q
E
G
V
E
V
R
-
V
A
R
I
F
N
T
F
G
P
R
M
H
M
---
N
DG-
R
V
V
S
N
F
I
L
Q
----
A
L
Q
G
-
E
P
L
T
V
Y
G
S
G
S
Q
T
R
A
F
Q
Y
V
S
D
L
V
N
-
G
-
L
V
A
L
M
N
S
N
-----
V
S
S
P
V
N
L
G
N
P
E
E
H
T
I
L
E
F
A
Q
L
I
K
N
-
L
V
G
-----
S
G
S
E
I
-------
Q
----
F
-
L
S
E
A
Q
D
D
P
Q
K
R
K
P
D
I
K
K
A
K
L
M
L
G
W
E
P
V
V
P
L
E
E
G
L
N
K
A
I
H
Y
F
-------
2
PsiBlast_PDB
75.94
34%
-14
- C1 -
1SB9
2
?
A:
[31-341]
---
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
T
L
L
K
L
D
Q
K
-----------
V
V
G
L
D
N
F
---
A
T
G
-
H
Q
R
-
N
L
D
E
V
-
R
S
L
V
S
E
K
Q
W
S
N
F
K
F
I
Q
G
D
I
R
N
L
D
D
-
C
N
N
---
A
C
A
--
G
V
---
D
Y
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
N
D
P
I
T
S
N
A
T
-
N
I
D
G
F
L
N
M
L
I
A
A
R
D
A
---------
K
V
Q
S
F
T
Y
A
A
S
S
-
S
-
T
Y
G
D
--
H
P
-
G
LP
K
-----------
V
-
E
D
-----
T
I
G
K
P
L
S
P
Y
A
V
T
K
Y
V
N
E
L
Y
A
D
V
F
S
R
C
Y
G
F
S
T
I
-
G
L
R
Y
F
N
V
F
G
R
R
Q
D
P
---
N
---
G
A
Y
A
A
V
I
P
K
W
T
S
S
M
I
Q
G
-
D
D
V
Y
I
N
G
D
G
E
T
S
R
D
F
C
Y
I
E
N
T
V
Q
-
A
N
L
L
A
A
T
A
G
L
D
---
A
R
N
Q
V
Y
N
I
A
V
G
G
R
T
S
L
N
Q
L
F
F
A
L
R
D
G
L
A
E
-----
N
G
V
S
Y
-------
H
R
E
P
V
Y
-
R
D
F
R
E
G
D
V
R
H
S
L
A
D
I
S
K
A
A
K
L
L
G
Y
A
P
K
Y
D
V
S
A
G
V
A
-------------
17
PsiBlast_PDB
75.27
29%
-23
- C1 -
4ZRN
2
?
A:
[4-307]
M
N
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
-
N
G
---
Y
------
G
-
V
I
V
V
D
N
L
S
-------
S
G
-
K
V
E
N
L
N
R
N
A
L
---------
F
Y
E
Q
S
I
E
D
-
E
E
-
M
M
E
---
R
I
F
--
S
L
HRP
E
Y
V
F
H
L
A
A
Q
A
S
V
A
I
S
V
R
E
P
A
R
D
-
A
K
T
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
---------
G
V
K
K
F
I
F
S
S
T
G
G
A
-
I
Y
G
E
NV
K
V
-
F
--
P
-----------
T
P
E
T
-----
E
I
P
H
P
I
S
P
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
F
F
A
R
E
Y
G
L
K
Y
T
-
V
L
R
Y
A
N
V
Y
G
P
R
Q
D
P
YGE
A
---
G
V
V
A
I
F
T
E
R
----
M
L
R
G
-
E
E
V
H
I
F
G
D
G
E
Y
V
R
D
Y
V
Y
V
D
D
V
V
R
-
A
-
N
L
L
A
M
E
K
G
D
-----
N
E
V
F
N
I
G
T
G
R
G
T
T
V
N
Q
L
F
K
L
L
K
E
-
I
T
G
-----
Y
D
K
E
P
-------
V
----
Y
-
K
P
P
R
K
G
D
V
R
K
S
I
L
D
Y
T
K
A
K
E
K
L
G
W
E
P
K
V
S
L
E
E
G
L
K
L
T
V
E
Y
F
-------
71
HHSearch
75.20
30%
-1
* C1 *
4ZRM
3
?
A:
[4-310]
M
N
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
-
N
-
G
--
Y
------
G
-
V
I
V
V
D
N
L
S
-
S
G
K
----
V
-
E
N
--------
L
N
R
N
---
A
L
F
Y
E
Q
S
I
E
D
-
E
E
M
M
E
R
---
I
F
S
L
H
R
P
---
E
Y
V
F
H
L
A
A
Q
A
S
V
A
I
S
V
R
E
-
P
A
R
D
A
K
T
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
---------
G
V
K
K
F
I
F
S
S
T
G
-
G
A
I
Y
G
E
--
N
V
-
K
VF
P
-----------
T
P
E
T
-----
E
I
P
H
P
I
S
P
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
F
F
A
R
E
Y
G
L
K
Y
T
-
V
L
R
Y
A
N
V
Y
G
P
R
Q
D
P
---
Y
GEA
G
V
V
A
I
F
T
E
R
----
M
L
R
G
-
E
E
V
H
I
F
G
D
G
E
Y
V
R
D
Y
V
Y
V
D
D
V
V
R
-
A
-
N
L
L
A
M
E
K
G
-----
D
N
E
V
F
N
I
G
T
G
R
G
T
T
V
N
Q
L
F
K
L
L
K
E
-
I
T
G
-----
Y
D
K
E
P
-------
V
----
Y
-
K
P
P
R
K
G
D
V
R
K
S
I
L
D
Y
T
K
A
K
E
K
L
G
W
E
P
K
V
S
L
E
E
G
L
K
L
T
V
E
Y
F
R
K
T
----
12
PsiBlast_PDB
74.82
33%
-17
- C1 -
3RUF
3
GNE_PLESH
A:
[29-338]
---
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
K
L
L
K
-
L
N
Q
--
V
--------
V
I
G
L
D
N
F
S
-
T
G
H
Q
-
Y
N
L
D
E
V
K
T
L
-
V
S
T
E
Q
W
S
R
---
F
C
F
I
E
G
D
I
---
R
D
-
L
T
T
C
E
Q
V
M
K
--
G
V
---
D
H
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
V
D
P
I
T
T
N
A
T
-
N
I
T
G
F
L
N
I
L
H
A
A
K
N
A
---------
Q
V
Q
S
F
T
Y
A
A
S
S
-
S
-
T
Y
G
D
--
H
P
-
A
LP
K
-----------
V
E
E
N
-----
I
G
-
N
P
L
S
P
Y
A
V
T
K
Y
V
N
E
I
Y
A
Q
V
Y
A
R
T
Y
G
F
K
T
I
-
G
L
R
Y
F
N
V
F
G
R
R
Q
D
P
---
N
---
G
A
Y
A
A
V
I
P
K
W
T
A
A
M
L
K
G
-
D
D
V
Y
I
N
G
D
G
E
T
S
R
D
F
C
Y
I
D
N
V
I
Q
M
N
-
I
L
S
A
L
A
K
D
S
---
A
K
D
N
I
Y
N
V
A
V
G
D
R
T
T
L
N
E
L
S
G
Y
I
Y
D
-
E
L
N
L
I
HHI------------
K
----
Y
-
R
E
F
R
S
G
D
V
R
H
S
Q
A
D
V
T
K
A
I
D
L
L
K
Y
R
P
N
I
K
I
R
E
G
L
--------------
64
HHSearch
74.63
30%
5
- C1 -
2HUN
1
?
A:
[4-314]
M
K
L
L
V
T
G
G
M
G
F
I
G
S
N
F
I
R
Y
I
L
E
-
K
-
H
P
D
W
------
E
-
V
I
N
I
D
K
L
G
-
Y
G
S
N
P
A
N
L
-
K
D
------
L
E
D
D
P
R
---
Y
T
F
V
K
G
D
V
A
D
-
Y
E
L
V
K
E
---
L
V
R
--
K
V
---
D
G
V
V
H
L
A
A
E
S
H
V
D
R
S
I
S
S
-
P
E
I
F
L
H
S
N
V
I
G
T
Y
T
L
L
E
S
I
R
R
E
N--------
P
E
V
R
F
V
H
V
S
T
D
-
E
-
V
Y
G
D
--
I
L
-
K
--
G
S
----------
F
T
E
N
-----
D
R
L
M
P
S
S
P
Y
S
A
T
K
A
A
S
D
M
L
V
L
G
W
T
R
T
Y
N
L
N
A
S
-
I
T
R
C
T
N
N
Y
G
P
Y
Q
F
P
---
E
---
K
L
I
P
K
T
I
I
R
----
A
S
L
G
-
L
K
I
P
I
Y
G
T
---
V
R
D
W
L
Y
V
E
D
H
V
R
-
A
-
I
E
L
V
L
L
K
G
----
E
S
R
E
I
Y
N
I
S
A
G
E
E
K
T
N
L
E
V
V
K
I
I
L
R
-
L
M
G
-----
K
G
E
E
L
-------
I
----
E
L
V
E
D
R
P
G
H
D
L
R
Y
S
L
D
S
W
K
I
T
R
D
L
K
W
R
P
K
Y
T
F
D
E
G
I
K
K
T
I
D
W
Y
L
K
N
----
57
HHSearch
74.20
29%
-13
- C1 -
1R6D
2
?
A:
[1-314]
M
R
L
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
-
G
-
A
--
Y
PDVPAD
E
-
V
I
V
L
D
S
L
T
-
Y
A
G
N
R
A
N
L
-
A
P
------
V
D
A
D
P
R
---
L
R
F
V
H
G
D
I
R
D
-
A
G
L
L
A
R
---
E
L
R
--
G
V
---
D
A
I
V
H
F
A
A
E
S
H
V
D
R
S
I
A
G
-
A
S
V
F
T
E
T
N
V
Q
G
T
Q
T
L
L
Q
C
A
V
D
A
---------
G
V
G
R
V
V
H
V
S
T
N
-
Q
-
V
Y
G
S
--
I
D
-
S
--
G
S
----------
W
T
E
S
-----
S
P
L
E
P
N
S
P
Y
A
A
S
K
A
G
S
D
L
V
A
R
A
Y
H
R
T
Y
G
L
D
V
R
-
I
T
R
C
C
N
N
Y
G
P
Y
Q
H
P
---
E
---
K
L
I
P
L
F
V
T
N
----
L
L
D
G
-
G
T
L
P
L
Y
G
D
G
A
N
V
R
E
W
V
H
T
D
D
H
C
R
-
G
-
I
A
L
V
L
A
G
G
----
R
A
G
E
I
Y
H
I
G
G
G
L
E
L
T
N
R
E
L
T
G
I
L
L
D
-
S
L
G
-----
A
D
W
S
S
-------
V
----
R
K
V
A
D
R
K
G
H
D
L
R
Y
S
L
D
G
G
K
I
E
R
E
L
G
Y
R
P
Q
V
S
F
A
D
G
L
A
R
T
V
R
W
Y
R
E
N
----
27
PsiBlast_CBE
73.90
33%
-15
- C1 -
3RUE
2
GNE_PLESH
S:
[29-338]
---
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
K
L
L
K
-
L
N
Q
--
V
--------
V
I
G
L
D
N
F
S
-
T
G
H
Q
-
Y
N
L
D
E
V
K
T
L
-
V
S
T
E
Q
W
S
R
---
F
C
F
I
E
G
D
I
---
R
D
-
L
T
T
CEQ
V
M
K
--
G
V
---
D
H
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
V
D
P
I
T
T
N
A
T
-
N
I
T
G
F
L
N
I
L
H
A
A
K
N
A
---------
Q
V
Q
S
F
T
Y
A
A
S
S
-
S
-
T
Y
G
D
--
H
P
-
A
LP
K
-----------
V
E
E
N
-----
I
G
-
N
P
L
S
P
Y
A
V
T
K
Y
V
N
E
I
Y
A
Q
V
Y
A
R
T
Y
G
F
K
T
I
-
G
L
R
Y
F
N
V
F
G
R
R
Q
D
P
---
N
---
G
A
Y
A
A
V
I
P
K
WTAA
M
L
K
G
-
D
D
V
Y
I
N
G
D
G
E
T
S
R
D
F
C
Y
I
D
N
V
I
Q
M
N
-
I
L
S
A
L
A
K
D
S
---
A
K
D
N
I
Y
N
V
A
V
G
D
R
T
T
L
N
E
L
S
G
Y
I
Y
D
-
E
L
N
LIHHI------------
K
----
Y
-
R
E
F
R
S
G
D
V
R
H
S
Q
A
D
V
T
K
A
I
D
L
L
K
Y
R
P
N
I
K
I
R
E
G
L
--------------
13
PsiBlast_PDB
73.65
33%
-16
- C1 -
3RUH
6
GNE_PLESH
A:
[29-338]
---
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
K
L
L
K
-
L
N
Q
--
V
--------
V
I
G
L
D
N
F
S
-
T
G
H
Q
-
Y
N
L
D
E
V
K
T
L
-
V
S
T
E
Q
W
S
R
---
F
C
F
I
E
G
D
I
---
R
D
-
L
T
T
C
E
Q
V
M
K
--
G
V
---
D
H
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
V
D
P
I
T
T
N
A
T
-
N
I
T
G
F
L
N
I
L
H
A
A
K
N
A
---------
Q
V
Q
S
F
T
Y
A
A
S
S
-
S
-
T
Y
G
D
--
H
P
-
A
LP
K
-----------
V
E
E
N
-----
I
G
-
N
P
L
S
P
Y
A
V
T
K
Y
V
N
E
I
Y
A
Q
V
Y
A
R
T
Y
G
F
K
T
I
-
G
L
R
Y
F
N
V
F
G
R
R
Q
D
P
---
N
---
G
A
Y
A
A
V
I
P
K
W
T
A
A
M
L
K
G
-
D
D
V
Y
I
N
G
D
G
E
T
S
R
D
F
C
Y
I
D
N
V
I
Q
M
N
-
I
L
S
A
L
A
K
D
S
---
A
K
D
N
I
Y
N
V
A
V
G
D
R
T
T
L
N
E
L
S
G
Y
I
Y
D
-
E
L
N
L
I
HHI------------
K
----
Y
-
R
E
F
R
S
G
D
V
R
H
S
Q
A
D
V
T
K
A
I
D
L
L
K
Y
R
P
N
I
K
I
R
E
G
L
--------------
22
PsiBlast_CBE
73.44
33%
-16
- C1 -
3RUE
2
GNE_PLESH
B:
[29-338]
---
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
K
L
L
K
-
L
N
Q
--
V
--------
V
I
G
L
D
N
F
S
-
T
G
H
Q
-
Y
N
L
D
E
V
K
T
L
-
V
S
T
E
Q
W
S
R
---
F
C
F
I
E
G
D
I
---
R
D
-
L
T
T
CEQ
V
M
K
--
G
V
---
D
H
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
V
D
P
I
T
T
N
A
T
-
N
I
T
G
F
L
N
I
L
H
A
A
K
N
A
---------
Q
V
Q
S
F
T
Y
A
A
S
S
-
S
-
T
Y
G
D
--
H
P
-
A
LP
K
-----------
V
E
E
N
-----
I
G
-
N
P
L
S
P
Y
A
V
T
K
Y
V
N
E
I
Y
A
Q
V
Y
A
R
T
Y
G
F
K
T
I
-
G
L
R
Y
F
N
V
F
G
R
R
Q
D
P
---
N
---
G
A
Y
A
A
V
I
P
K
WTAA
M
L
K
G
-
D
D
V
Y
I
N
G
D
G
E
T
S
R
D
F
C
Y
I
D
N
V
I
Q
M
N
-
I
L
S
A
L
A
K
D
S
---
A
K
D
N
I
Y
N
V
A
V
G
D
R
T
T
L
N
E
L
S
G
Y
I
Y
D
-
E
L
N
LIHHI------------
K
----
Y
-
R
E
F
R
S
G
D
V
R
H
S
Q
A
D
V
T
K
A
I
D
L
L
K
Y
R
P
N
I
K
I
R
E
G
L
--------------
49
PsiBlast_CBE
73.14
31%
0
- C- -
3EHE
1
?
A:
[4-269]
--
I
V
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
---
S
E
S
--
N
------
E
-
I
V
V
I
D
N
L
S
S
G
N
E
E
-
F
V
N
-
E
A
A
R
L
---------------
V
K
A
D
L
A
A
-
D
D
-
I
K
D
---
Y
L
K
--
G
A
---
E
E
V
W
H
I
A
A
N
P
D
V
R
-
G
A
E
N
P
D
E
I
Y
R
-
N
N
V
L
A
T
Y
R
L
L
E
A
M
R
K
A
---------
G
V
S
R
I
V
F
T
S
T
S
-
T
-
V
Y
G
E
A-
K
V
-
I
--
P
-----------
T
P
E
D
-----
Y
P
T
H
P
I
S
L
Y
G
A
S
K
L
A
C
E
A
L
I
E
S
Y
C
H
T
F
D
M
Q
A
W
-
I
Y
R
F
A
N
V
I
G
R
R
S
T
H
---
G
---
V
I
Y
D
F
I
M
K
L
----
K
R
N
P
-
E
E
L
E
I
L
G
N
G
E
Q
N
K
S
Y
I
Y
I
S
D
C
V
D
-
A
-
M
L
F
G
L
R
G
D
E
---
R
V
N
-
I
F
N
I
G
S
E
D
Q
I
K
V
K
R
I
A
E
I
V
C
E
-
E
L
G
-----
L
S
P
R
F
-------
R
----
F
-
T
-----------------------------------------------
48
PsiBlast_CBE
73.14
31%
0
- C- -
3EHE
1
?
B:
[4-269]
--
I
V
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
---
S
E
S
--
N
------
E
-
I
V
V
I
D
N
L
S
S
G
N
E
E
-
F
V
N
-
E
A
A
R
L
---------------
V
K
A
D
L
A
A
-
D
D
-
I
K
D
---
Y
L
K
--
G
A
---
E
E
V
W
H
I
A
A
N
P
D
V
R
-
G
A
E
N
P
D
E
I
Y
R
-
N
N
V
L
A
T
Y
R
L
L
E
A
M
R
K
A
---------
G
V
S
R
I
V
F
T
S
T
S
-
T
-
V
Y
G
E
A-
K
V
-
I
--
P
-----------
T
P
E
D
-----
Y
P
T
H
P
I
S
L
Y
G
A
S
K
L
A
C
E
A
L
I
E
S
Y
C
H
T
F
D
M
Q
A
W
-
I
Y
R
F
A
N
V
I
G
R
R
S
T
H
---
G
---
V
I
Y
D
F
I
M
K
L
----
K
R
N
P
-
E
E
L
E
I
L
G
N
G
E
Q
N
K
S
Y
I
Y
I
S
D
C
V
D
-
A
-
M
L
F
G
L
R
G
D
E
---
R
V
N
-
I
F
N
I
G
S
E
D
Q
I
K
V
K
R
I
A
E
I
V
C
E
-
E
L
G
-----
L
S
P
R
F
-------
R
----
F
-
T
-----------------------------------------------
40
PsiBlast_CBE
73.07
32%
-11
- C1 -
3LU1
5
GNE_PLESH
D:
[42-363]
---
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
K
L
L
K
-
L
N
Q
--
V
--------
V
I
G
L
D
N
F
S
-
T
G
H
Q
-
Y
N
L
D
E
V
K
T
L
-
V
S
T
E
Q
W
S
R
---
F
C
F
I
E
G
D
I
---
R
D
-
L
T
T
CEQ
V
M
K
--
G
V
---
D
H
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
V
D
P
I
T
T
N
A
T
-
N
I
T
G
F
L
N
I
L
H
A
A
K
N
A
---------
Q
V
Q
S
F
T
Y
A
A
S
S
-
S
-
T
Y
G
D
--
H
P
-
A
LP
K
-----------
V
E
E
N
-----
I
G
-
N
P
L
S
P
Y
A
V
T
K
Y
V
N
E
I
Y
A
Q
V
Y
A
R
T
Y
G
F
K
T
I
-
G
L
R
Y
F
N
V
F
G
R
R
Q
D
P
---
N
---
G
A
Y
A
A
V
I
P
K
WTAA
M
L
K
G
-
D
D
V
Y
I
N
G
D
G
E
T
S
R
D
F
C
Y
I
D
N
V
I
Q
M
N
-
I
L
S
A
L
A
K
D
S
---
A
K
D
N
I
Y
N
V
A
V
G
D
R
T
T
L
N
E
L
S
G
Y
I
Y
D
-
E
L
N
LIHHI------------
K
----
Y
-
R
E
F
R
S
G
D
V
R
H
S
Q
A
D
V
T
K
A
I
D
L
L
K
Y
R
P
N
I
K
I
R
E
G
L
R
L
S
M
P
W
Y
V
R
F
L
K
--
11
PsiBlast_PDB
73.06
33%
-16
- C1 -
3RUE
2
GNE_PLESH
A:
[29-338]
---
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
K
L
L
K
-
L
N
Q
--
V
--------
V
I
G
L
D
N
F
S
-
T
G
H
Q
-
Y
N
L
D
E
V
K
T
L
-
V
S
T
E
Q
W
S
R
---
F
C
F
I
E
G
D
I
---
R
D
-
L
T
T
C
E
Q
V
M
K
--
G
V
---
D
H
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
V
D
P
I
T
T
N
A
T
-
N
I
T
G
F
L
N
I
L
H
A
A
K
N
A
---------
Q
V
Q
S
F
T
Y
A
A
S
S
-
S
-
T
Y
G
D
--
H
P
-
A
LP
K
-----------
V
E
E
N
-----
I
G
-
N
P
L
S
P
Y
A
V
T
K
Y
V
N
E
I
Y
A
Q
V
Y
A
R
T
Y
G
F
K
T
I
-
G
L
R
Y
F
N
V
F
G
R
R
Q
D
P
---
N
---
G
A
Y
A
A
V
I
P
K
W
T
A
A
M
L
K
G
-
D
D
V
Y
I
N
G
D
G
E
T
S
R
D
F
C
Y
I
D
N
V
I
Q
M
N
-
I
L
S
A
L
A
K
D
S
---
A
K
D
N
I
Y
N
V
A
V
G
D
R
T
T
L
N
E
L
S
G
Y
I
Y
D
-
E
L
N
L
I
HHI------------
K
----
Y
-
R
E
F
R
S
G
D
V
R
H
S
Q
A
D
V
T
K
A
I
D
L
L
K
Y
R
P
N
I
K
I
R
E
G
L
--------------
46
PsiBlast_CBE
66.12
31%
-55
- C1 -
3VPS
2
?
B:
[9-255]
-
R
I
L
I
T
G
G
A
G
F
I
G
G
H
L
A
R
A
L
V
A
-
S
G
E
--
E
------
V
-
T
V
-
L
D
D
L
R
-
V
P
-------------
P
M
I
P
P
E
G
T
---
G
K
F
L
E
K
P
V
L
E
-
L
E
-
E
R
D
---
L
S
D
---
V
---
R
L
V
Y
H
L
A
S
H
K
S
V
P
R
S
F
K
Q
P
L
D
--
Y
L
D
N
V
D
S
G
R
H
L
L
A
L
C
T
S
V
---------
G
V
P
K
V
V
V
G
S
T
C
-
E
-
V
Y
G
Q
--
A
D
-
T
L-
P
-----------
T
P
E
D
-----
S
P
L
S
P
R
S
P
Y
A
A
S
K
V
G
L
E
M
V
A
G
A
H
Q
R
A
S
V
A
P
E
V
G
I
V
R
F
F
N
V
Y
G
P
G
E
R
P
---
D
---
A
L
V
P
R
L
C
A
N
----
L
L
T
R
-
N
E
L
P
V
E
G
D
G
E
Q
R
R
D
F
T
Y
I
T
D
V
V
D
-
K
-
L
V
A
L
A
N
R
P
-----
L
P
S
V
V
N
F
G
S
G
Q
S
L
S
V
N
D
V
I
R
I
L
Q
A
-
T
S
-------------------------------------------------------------------------
47
PsiBlast_CBE
64.81
31%
-56
- C1 -
3VPS
2
?
A:
[9-253]
-
R
I
L
I
T
G
G
A
G
F
I
G
G
H
L
A
R
A
L
V
A
-
S
G
E
--
E
------
V
-
T
V
-
L
D
D
L
R
-
V
P
-------------
P
M
I
P
P
E
G
T
---
G
K
F
L
E
K
P
V
L
E
-
L
E
-
E
R
D
---
L
S
D
---
V
---
R
L
V
Y
H
L
A
S
H
K
S
V
P
R
S
F
K
Q
P
L
D
--
Y
L
D
N
V
D
S
G
R
H
L
L
A
L
C
T
S
V
---------
G
V
P
K
V
V
V
G
S
T
C
-
E
-
V
Y
G
Q
--
A
D
-
T
L-
P
-----------
T
P
E
D
-----
S
P
L
S
P
R
S
P
Y
A
A
S
K
V
G
L
E
M
V
A
G
A
H
Q
R
A
S
V
A
P
E
V
G
I
V
R
F
F
N
V
Y
G
P
G
E
R
P
---
D
---
A
L
V
P
R
L
C
A
N
----
L
L
T
R
-
N
E
L
P
V
E
G
D
G
E
Q
R
R
D
F
T
Y
I
T
D
V
V
D
-
K
-
L
V
A
L
A
N
R
P
-----
L
P
S
V
V
N
F
G
S
G
Q
S
L
S
V
N
D
V
I
R
I
L
Q
A
-
T
S
-------------------------------------------------------------------------