@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu37720: (2016-08-02 )
MERKTVLVIADLGGCPPHMFYKSAAEKYNLVSFIPRPFAITASHAALIEKYSVAVIKDKDYFKSLADFEHPDSIYWAHEDHDKPEEEVVEEIVKVAGMFAVDAITTNNELFIAPMAKACERLGLRGAGVQAAENARDKNKMRAAFNRAGVKSIKNKRVTTLEDFRAALQEIGTPLILKPTYLASSIGVTLIKEMETAEAEFNRVNEYLKSINVPKAVTFEAPFIAEEFLQGEYDDWYETSGYSDYISIEGIMADGEYFPVAIHDKTPQIGFTETSHITPSILDDDAKRKIVEAAKKANEGLGLENCATHTEIKLMKNREAGLIESAARFAGWNMIPNIKKVFGVDMAQLLLDVLCFGKEADLPKGLLEQEPCYVADCHLYPQHFKENGQLPETAVDFVIESIDIPDGVLKGDTEIVSFSAAEAGTSVDLRLFEAFNSIAAFELKGSNSGDVAESIKQIQQQAKLTAKYALPV
Atome Classification :
(20 SA)
-------.........10........20........30........40........50........60........70........----80.----.......--90.......-.100....-...110.--.--......120...--.-...130.......140...-....150....--..---.160.......170.......180.......190--........200.......210.......220.......230-.------------.......240.......250.-......260......-------.270.........280-.-.......290.-----....---...300..-.....310....-...320.......330....-..-.340........350....-...360.......370.......380-..-.-...------.--------.------390-......--..---------400...----....410.-...--....-420.......-430.-----.......440.......450.......460.......470
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------ME
R
K
T
V
L
V
I
ADLGGC
P
P
H
M
F
Y
K
S
A
A
E
KY
N
L
VSFIPR
P
F
A
I
T
A
S
H
A
A
L
I
E
K
Y
S
V
A
V
I
K
D
K
D
Y
F
K
S
L
ADFEHPD
S
I
Y
W
AHE----DHD----K
P
E
E
E
V
V
--
E
E
I
V
K
V
A
G
M
-
F
A
V
D
A
ITT-NN
E
L
F
-I--A--
P
M
A
K
A
C
E
R
LGLR--G-AGVQ
A
A
E
NAR
D
K
N
K
M
R
A
A
F
-
N
R
A
G
V
K
S
I
KNK--RV---T
T
L
E
D
F
R
A
A
L
Q
EIGT
P
L
I
L
K
P
T
Y
L
A
S
S
I
G
V
T
L
I
---
K
E
M
E
T
A
E
A
E
F
N
R
V
N
E
Y
L
K
SINVP
K
A
V
TFEA
P
F
I
A
E
E
F
LQ-G-E------------YDDWYETSGYS
D
Y
I
S
I
E
G
I
M
A-DG
E
Y
F
P
V
A
IHDKTPQ-------IG--FTETSHI
T
P
S
-I-L-
D
D
D
A
K
R
K
I
V
-
E
-----
A
A
K
K
---ANEGLGLE-NCATH
T
E
I
K
L
M
K-NREA
G
L
I
E
S
A
A
R
FAGWNMIP-
N
I
-
K
K
V
-
F
G
V
D
M
A
Q
L
L
L
D
V
L
CF-GKEADLP
K
G
L
L
EQEP
C
Y
V
ADCHL
Y
P
--
Q
H
-
F
-KEN------G--------Q------L-
P
-
E
T
A
V
D
F
--
V
I
---------
E
SIDIP----DGVLK-GD-T
E
I
--
V
S
F
S-AAEAGT
S
V
D
L
-
R
L
-
F
-----
E
A
F
NSI
A
A
F
E
L
KGSNS
G
D
V
A
E
S
I
K
Q
I
Q
Q
Q
A
K
L
T
A
K
YALPV
23
Fugue
98.33
91%
-84
- C2 -
3VMM
4
BACD_BACSU
A:
[4-474]
--------
E
R
K
T
V
L
V
I
A
D
L
G
G
C
P
P
H
M
F
Y
K
S
A
A
E
K
Y
N
L
V
S
F
I
P
R
P
F
A
I
T
A
S
H
A
A
L
I
E
K
Y
S
V
A
V
I
K
D
K
D
Y
F
K
S
L
A
D
F
E
H
P
D
S
I
Y
W
A
H
E
----
D
H
N
----
K
P
E
E
E
V
V
--
E
Q
I
V
K
V
A
E
M
-
F
G
A
D
A
I
T
T
-
N
N
E
L
F
-
I
--
A
--
P
M
A
K
A
C
E
R
L
G
L
R
--
G
-
A
G
V
Q
A
A
E
N
A
R
D
K
N
K
M
R
D
A
F
-
N
K
A
G
V
K
S
I
K
N
K
--
R
V
---
T
T
L
E
D
F
R
A
A
L
E
E
I
G
T
P
L
I
L
K
P
T
Y
L
A
S
S
I
G
V
T
L
I
---
T
D
T
E
T
A
E
D
E
F
N
R
V
N
D
Y
L
K
S
I
N
V
P
K
A
V
T
F
E
A
P
F
I
A
E
E
F
L
Q
-
G
-
E
------------
Y
G
D
W
Y
Q
T
E
G
Y
S
D
Y
I
S
I
E
G
I
M
A
-
D
G
E
Y
F
P
I
A
I
H
D
K
T
P
Q
-------
I
G
--
F
T
E
T
S
H
I
T
P
S
-
I
-
L
-
D
E
E
A
K
K
K
I
V
-
E
-----
A
A
K
K
---
A
N
E
G
L
G
L
Q
-
N
C
A
T
H
T
E
I
K
L
M
K
-
N
R
E
P
G
L
I
E
S
A
A
R
F
A
G
W
N
M
I
P
-
N
I
-
K
K
V
-
F
G
L
D
M
A
Q
L
L
L
D
V
L
C
F
-
G
K
D
A
D
L
P
D
G
L
L
D
Q
E
P
Y
Y
V
A
D
C
H
L
Y
P
--
Q
H
-
F
-
K
Q
N
------
G
--------
Q
------
I
-
P
-
E
T
A
E
D
L
--
V
I
---------
E
A
I
D
I
P
----
D
G
L
L
K
-
G
D
-
T
E
I
--
V
S
F
S
-
A
A
A
P
G
T
S
V
D
L
-
T
L
-
F
-----
E
A
F
N
S
I
A
A
F
E
L
K
G
S
N
S
Q
D
V
A
E
S
I
R
Q
I
Q
Q
H
A
K
L
T
A
K
Y
V
L
P
V
1
PsiBlast_PDB
98.33
91%
-84
- C2 -
3VMM
4
BACD_BACSU
A:
[4-474]
--------
E
R
K
T
V
L
V
I
A
D
L
G
G
C
P
P
H
M
F
Y
K
S
A
A
E
K
Y
N
L
V
S
F
I
P
R
P
F
A
I
T
A
S
H
A
A
L
I
E
K
Y
S
V
A
V
I
K
D
K
D
Y
F
K
S
L
A
D
F
E
H
P
D
S
I
Y
W
A
H
E
----
D
H
N
----
K
P
E
E
E
V
V
--
E
Q
I
V
K
V
A
E
M
-
F
G
A
D
A
I
T
T
-
N
N
E
L
F
-
I
--
A
--
P
M
A
K
A
C
E
R
L
G
L
R
--
G
-
A
G
V
Q
A
A
E
N
A
R
D
K
N
K
M
R
D
A
F
-
N
K
A
G
V
K
S
I
K
N
K
--
R
V
---
T
T
L
E
D
F
R
A
A
L
E
E
I
G
T
P
L
I
L
K
P
T
Y
L
A
S
S
I
G
V
T
L
I
---
T
D
T
E
T
A
E
D
E
F
N
R
V
N
D
Y
L
K
S
I
N
V
P
K
A
V
T
F
E
A
P
F
I
A
E
E
F
L
Q
-
G
-
E
------------
Y
G
D
W
Y
Q
T
E
G
Y
S
D
Y
I
S
I
E
G
I
M
A
-
D
G
E
Y
F
P
I
A
I
H
D
K
T
P
Q
-------
I
G
--
F
T
E
T
S
H
I
T
P
S
-
I
-
L
-
D
E
E
A
K
K
K
I
V
-
E
-----
A
A
K
K
---
A
N
E
G
L
G
L
Q
-
N
C
A
T
H
T
E
I
K
L
M
K
-
N
R
E
P
G
L
I
E
S
A
A
R
F
A
G
W
N
M
I
P
-
N
I
-
K
K
V
-
F
G
L
D
M
A
Q
L
L
L
D
V
L
C
F
-
G
K
D
A
D
L
P
D
G
L
L
D
Q
E
P
Y
Y
V
A
D
C
H
L
Y
P
--
Q
H
-
F
-
K
Q
N
------
G
--------
Q
------
I
-
P
-
E
T
A
E
D
L
--
V
I
---------
E
A
I
D
I
P
----
D
G
L
L
K
-
G
D
-
T
E
I
--
V
S
F
S
-
A
A
A
P
G
T
S
V
D
L
-
T
L
-
F
-----
E
A
F
N
S
I
A
A
F
E
L
K
G
S
N
S
Q
D
V
A
E
S
I
R
Q
I
Q
Q
H
A
K
L
T
A
K
Y
V
L
P
V
2
PsiBlast_PDB
98.25
91%
-85
- C2 -
3WNZ
4
BACD_BACSU
A:
[6-470]
----------
K
T
V
L
V
I
A
D
L
G
G
C
P
P
H
M
F
Y
K
S
A
A
E
K
Y
N
L
V
S
F
I
P
R
P
F
A
I
T
A
S
H
A
A
L
I
E
K
Y
S
V
A
V
I
K
D
K
D
Y
F
K
S
L
A
D
F
E
H
P
D
S
I
Y
W
A
H
E
----
D
H
N
----
K
P
E
E
E
V
V
--
E
Q
I
V
K
V
A
E
M
-
F
G
A
D
A
I
T
T
-
N
N
E
L
F
-
I
--
A
--
P
M
A
K
A
C
E
R
L
G
L
R
--
G
-
A
G
V
Q
A
A
E
N
A
R
D
K
N
K
M
R
D
A
F
-
N
K
A
G
V
K
S
I
K
N
K
--
R
V
---
T
T
L
E
D
F
R
A
A
L
E
E
I
G
T
P
L
I
L
K
P
T
Y
L
A
S
S
I
G
V
T
L
I
---
T
D
T
E
T
A
E
D
E
F
N
R
V
N
D
Y
L
K
S
I
N
V
P
K
A
V
T
F
E
A
P
F
I
A
E
E
F
L
Q
-
G
-
E
------------
Y
G
D
W
Y
Q
T
E
G
Y
S
D
Y
I
S
I
E
G
I
M
A
-
D
G
E
Y
F
P
I
A
I
H
D
K
T
P
Q
-------
I
G
--
F
T
E
T
S
H
I
T
P
S
-
I
-
L
-
D
E
E
A
K
K
K
I
V
-
E
-----
A
A
K
K
---
A
N
E
G
L
G
L
Q
-
N
C
A
T
H
T
E
I
K
L
M
K
-
N
R
E
P
G
L
I
E
S
A
A
R
F
A
G
W
N
M
I
P
-
N
I
-
K
K
V
-
F
G
L
D
M
A
Q
L
L
L
D
V
L
C
F
-
G
K
D
A
D
L
P
D
G
L
L
D
Q
E
P
Y
Y
V
A
D
C
H
L
Y
P
--
Q
H
-
F
-
K
Q
N
------
G
--------
Q
------
I
-
P
-
E
T
A
E
D
L
--
V
I
---------
E
A
I
D
I
P
----
D
G
L
L
K
-
G
D
-
T
E
I
--
V
S
F
S
-
A
A
A
P
G
T
S
V
D
L
-
T
L
-
F
-----
E
A
F
N
S
I
A
A
F
E
L
K
G
S
N
S
Q
D
V
A
E
S
I
R
Q
I
Q
Q
H
A
K
L
T
A
K
Y
----
4
PsiBlast_PDB
97.78
91%
-84
- C2 -
3WO1
4
BACD_BACSU
A:
[6-470]
----------
K
T
V
L
V
I
A
D
L
G
G
C
P
P
H
M
F
Y
K
S
A
A
E
K
Y
N
L
V
S
F
I
P
R
P
F
A
I
T
A
S
H
A
A
L
I
E
K
Y
S
V
A
V
I
K
D
K
D
Y
F
K
S
L
A
D
F
E
H
P
D
S
I
Y
W
A
H
E
----
D
H
N
----
K
P
E
E
E
V
V
--
E
Q
I
V
K
V
A
E
M
-
F
G
A
D
A
I
T
T
-
N
N
E
L
F
-
I
--
A
--
P
M
A
K
A
C
E
R
L
G
L
R
--
G
-
A
G
V
Q
A
A
E
N
A
R
D
K
N
K
M
R
D
A
F
-
N
K
A
G
V
K
S
I
K
N
K
--
R
V
---
T
T
L
E
D
F
R
A
A
L
E
E
I
G
T
P
L
I
L
K
P
T
Y
L
A
S
S
I
G
V
T
L
I
---
T
D
T
E
T
A
E
D
E
F
N
R
V
N
D
Y
L
K
S
I
N
V
P
K
A
V
T
F
E
A
P
F
I
A
E
E
F
L
Q
-
G
-
E
------------
Y
G
D
W
Y
Q
T
E
G
Y
S
D
Y
I
S
I
E
G
I
M
A
-
D
G
E
Y
F
P
I
A
I
H
D
K
T
P
Q
-------
I
G
--
F
T
E
T
S
H
I
T
P
S
-
I
-
L
-
D
E
E
A
K
K
K
I
V
-
E
-----
A
A
K
K
---
A
N
E
G
L
G
L
Q
-
N
C
A
T
H
T
E
I
K
L
M
K
-
N
R
E
P
G
L
I
E
S
A
A
R
F
A
G
A
N
M
I
P
-
N
I
-
K
K
V
-
F
G
L
D
M
A
Q
L
L
L
D
V
L
C
F
-
G
K
D
A
D
L
P
D
G
L
L
D
Q
E
P
Y
Y
V
A
D
C
H
L
Y
P
--
Q
H
-
F
-
K
Q
N
------
G
--------
Q
------
I
-
P
-
E
T
A
E
D
L
--
V
I
---------
E
A
I
D
I
P
----
D
G
L
L
K
-
G
D
-
T
E
I
--
V
S
F
S
-
A
A
A
P
G
T
S
V
D
L
-
T
L
-
F
-----
E
A
F
N
S
I
A
A
F
E
L
K
G
S
N
S
Q
D
V
A
E
S
I
R
Q
I
Q
Q
H
A
K
L
T
A
K
Y
----
3
PsiBlast_PDB
97.41
91%
-83
- C2 -
3WO0
4
BACD_BACSU
A:
[6-470]
----------
K
T
V
L
V
I
A
D
L
G
G
C
P
P
H
M
F
Y
K
S
A
A
E
K
Y
N
L
V
S
F
I
P
R
P
F
A
I
T
A
S
H
A
A
L
I
E
K
Y
S
V
A
V
I
K
D
K
D
Y
F
K
S
L
A
D
F
E
H
P
D
S
I
Y
W
A
H
E
----
D
H
N
----
K
P
E
E
E
V
V
--
E
Q
I
V
K
V
A
E
M
-
F
G
A
D
A
I
T
T
-
N
N
E
L
F
-
I
--
A
--
P
M
A
K
A
C
E
R
L
G
L
R
--
G
-
A
G
V
Q
A
A
E
N
A
R
D
K
N
K
M
R
D
A
F
-
N
K
A
G
V
K
S
I
K
N
K
--
R
V
---
T
T
L
E
D
F
R
A
A
L
E
E
I
G
T
P
L
I
L
K
P
T
Y
L
A
S
S
I
G
V
T
L
I
---
T
D
T
E
T
A
E
D
E
F
N
R
V
N
D
Y
L
K
S
I
N
V
P
K
A
V
T
F
E
A
P
F
I
A
E
E
F
L
Q
-
G
-
E
------------
Y
G
D
W
Y
Q
T
E
G
Y
S
D
Y
I
S
I
E
G
I
M
A
-
D
G
E
Y
F
P
I
A
I
H
D
K
T
P
Q
-------
I
G
--
F
T
E
T
S
H
I
T
P
S
-
I
-
L
-
D
E
E
A
K
K
K
I
V
-
E
-----
A
A
K
K
---
A
N
E
G
L
G
L
Q
-
N
C
A
T
H
T
E
I
K
L
M
K
-
N
R
E
P
G
L
I
E
S
A
A
R
F
A
G
W
N
M
I
P
-
N
I
-
K
K
V
-
F
G
L
D
M
A
Q
L
L
L
D
V
L
C
F
-
G
K
D
A
D
L
P
D
G
L
L
D
Q
E
P
Y
Y
V
A
D
C
H
L
Y
P
--
Q
H
-
F
-
K
Q
N
------
G
--------
Q
------
I
-
P
-
E
T
A
E
D
L
--
V
I
---------
E
A
I
D
I
P
----
D
G
L
L
K
-
G
D
-
T
E
I
--
V
S
F
S
-
A
A
A
P
G
T
S
V
D
L
-
T
L
-
F
-----
E
A
F
N
S
I
A
A
F
E
L
K
G
S
N
S
Q
D
V
A
E
S
I
R
Q
I
Q
Q
H
A
K
L
T
A
K
Y
----
36
HHSearch
70.36
79%
-3
- C2 -
3WNZ
4
BACD_BACSU
A:
[86-468]
--------------------------------------------------------------------------------------------------
P
E
E
E
V
V
--
E
Q
I
V
K
V
A
E
M
-
F
G
A
D
A
I
T
T
-
N
N
E
L
F
-
I
--
A
--
P
M
A
K
A
C
E
R
L
G
L
R
--
G
-
A
G
V
Q
A
A
E
N
A
R
D
K
N
K
M
R
D
A
F
-
N
K
A
G
V
K
S
I
K
N
K
--
R
V
---
T
T
L
E
D
F
R
A
A
L
E
E
I
G
T
P
L
I
L
K
P
T
Y
L
A
S
S
I
G
V
T
L
I
---
T
D
T
E
T
A
E
D
E
F
N
R
V
N
D
Y
L
K
S
I
N
V
P
K
A
V
T
F
E
A
P
F
I
A
E
E
F
L
Q
-
G
-
E
YGDWYQTEGYSD
Y
------------
I
S
I
E
G
I
M
A
-
D
G
E
Y
F
P
I
A
I
H
D
K
T
P
Q
-------
I
G
--
F
T
E
T
S
H
I
T
P
S
-
I
-
L
-
D
E
E
A
K
K
K
I
V
-
E
-----
A
A
K
K
---
A
N
E
G
L
G
L
Q
-
N
C
A
T
H
T
E
I
K
L
M
K
-
N
R
E
P
G
L
I
E
S
A
A
R
F
A
G
W
N
M
I
P
-
N
I
-
K
K
V
-
F
G
L
D
M
A
Q
L
L
L
D
V
L
C
F
G
K
D
A
D
L
P
D
G
L
L
-
D
Q
---------
E
P
Y
--
Y
V
-
A
-
D
C
H
------
L
--------
Y
------
P
Q
H
F
K
Q
N
G
Q
I
--
P
E
TAE
D
L
V
I
E
A
I
--
D
I
P
----
D
G
L
L
K
-
G
D
T
E
I
V
--
S
F
S
--
A
A
A
P
G
T
S
V
D
L
T
L
F
E
A
-----
F
N
S
I
A
A
F
E
L
K
--
G
S
N
S
Q
D
V
A
E
S
I
R
Q
I
Q
Q
H
A
K
L
T
A
------
35
HHSearch
58.11
20%
-34
- C2 -
3VOT
7
?
A:
[3-417]
-------
K
R
N
K
N
L
A
I
I
C
Q
-
N
-
K
H
L
P
F
I
F
E
E
A
E
R
L
-
G
L
K
-----
V
T
F
F
Y
N
S
A
E
D
F
P
G
N
L
-----------------
P
A
V
E
R
C
V
P
L
P
L
----
F
------
E
D
E
E
A
A
M
--
D
V
V
R
Q
T
F
V
E
-
F
P
F
D
G
V
M
T
-
L
F
E
P
A
-
L
--
P
--
F
T
A
K
A
A
E
A
L
N
L
P
--
G
-
L
P
F
T
T
M
E
N
C
R
N
K
N
K
T
R
S
I
L
-
Q
Q
N
G
L
N
T
P
V
F
H
--
E
F
---
H
T
L
A
D
L
E
N
--
R
K
L
S
Y
P
L
V
V
K
P
V
N
-----
G
V
V
R
V
---
D
D
R
K
E
L
E
E
A
V
R
K
V
E
A
V
N
Q
R
D
-
L
N
R
F
V
H
G
K
T
G
I
V
A
E
Q
F
I
D
-
G
-
P
------------
E
------------
F
A
I
E
T
L
S
I
-
Q
G
N
V
H
V
L
S
I
G
Y
K
G
N
S
KG-----
P
F
--
F
E
E
G
V
Y
I
A
P
A
-
Q
-
L
-
K
E
E
T
R
L
A
I
V
-
K
-----
E
V
T
G
---
A
V
S
A
L
G
I
H
-
Q
G
P
A
H
T
E
L
R
L
D
K
-
D
G
T
P
Y
V
I
E
V
G
A
R
I
G
G
S
G
V
S
H
Y
I
V
-
K
E
S
-
T
G
I
N
F
M
Q
L
V
L
Q
N
A
L
K
-
P
L
E
S
S
E
F
E
G
E
-
I
R
---------
P
V
R
--
T
A
-
G
-
N
Y
I
------
I
--------
P
--------
V
-
Q
G
S
G
T
F
--
E
K
---------
I
--
D
G
L
----
E
E
V
K
Q
-
R
Q
-
E
V
K
--
R
V
F
Q
-
F
M
R
R
G
A
K
I
L
P
-
Y
P
H
F
-----
S
G
Y
P
G
F
I
L
T
S
--
H
H
S
Y
E
E
C
E
A
F
Y
R
E
L
D
D
E
L
H
I
I
Y
Q
N
----
28
Fugue
51.84
18%
-97
- C2 -
4FFL
8
?
A:
[1-363]
---------
M
K
T
I
C
L
V
-
G
G
K
L
Q
G
F
E
A
A
Y
L
S
K
K
A
G
M
K
V
V
L
V
D
K
N
P
Q
A
L
I
R
N
Y
A
------------
D
E
F
Y
C
F
D
V
--------------------
I
----
K
E
P
E
K
L
L
--
E
L
S
K
R
V
D
A
V
-
L
P
V
N
E
N
L
A
-
C
I
E
F
L
-
N
--
S
--
I
K
E
K
F
S
C
P
V
L
F
D
------
F
E
A
Y
R
I
S
R
D
K
K
K
S
K
D
Y
F
-
K
S
I
G
V
P
T
P
Q
D
R
--
P
----------------
S
K
P
P
Y
F
V
K
P
P
C
E
S
S
S
V
G
A
R
I
I
---
Y
G
L
E
P
-------------------------
D
T
L
V
E
E
Y
V
E
-
G
-------------------------
E
V
V
S
L
E
V
V
G
D
-
G
S
H
F
A
V
V
K
E
-----
T
-------
L
V
--
H
I
D
E
T
Y
D
C
H
M
-
V
-
T
-
P
L
P
A
N
P
L
F
R
-
Q
-----
I
S
H
D
---
L
A
A
N
L
P
L
K
-
G
I
M
D
V
E
A
I
F
G
---
P
K
G
L
R
V
I
E
I
D
A
R
F
P
S
-
Q
T
P
T
-
V
V
-
Y
Y
S
-
S
G
I
N
L
I
E
L
L
F
R
A
F
---------
T
D
G
V
E
E
I
E
N
K
Y
C
I
Y
E
H
L
M
F
-------
G
E
N
------
G
--------
V
------
L
-
I
-
P
V
G
E
Q
V
--
L
-----------------------------
S
M
G
--
S
D
Y
G
-
K
F
Y
E
E
P
G
I
E
I
-
F
L
-
C
-----
K
G
E
Y
P
V
F
T
M
V
F
W
G
K
D
R
E
E
T
G
A
K
R
C
K
G
L
S
V
L
K
E
R
F
G
A
V
L
--
44
HHSearch
50.49
17%
18
- C2 -
2VPQ
4
?
A:
[2-413]
----------
K
K
V
L
I
A
N
R
G
--
E
I
A
V
R
I
I
R
A
C
R
D
L
-
G
I
Q
-----
T
V
A
I
Y
S
E
G
D
K
D
A
L
H
T
-----------------
Q
I
A
D
E
A
Y
C
V
G
P
----
T
------
L
S
K
D
S
Y
L
N
I
P
N
I
L
S
I
A
T
S
-
T
G
C
D
G
V
H
P
-
G
Y
G
F
L
-
A
EN
A
--
D
F
A
E
L
C
E
A
C
Q
L
K
FI
G
-
P
S
Y
Q
S
I
Q
K
M
G
I
K
D
V
A
K
A
E
M
-
I
K
A
N
V
P
V
V
P
G
S
DG
L
M
---
K
D
V
S
E
A
K
K
I
A
K
K
I
G
Y
P
V
I
I
K
A
T
A
G
G
G
G
K
G
I
R
V
A
---
R
D
E
K
E
L
E
T
G
F
R
M
T
E
Q
E
A
Q
T
-
A
F
G
N
-----
G
G
L
Y
M
E
K
F
I
E
-
N
F
R
------------
H
------------
I
E
I
Q
I
V
G
D
S
Y
G
N
V
I
H
L
G
E
R
D
C
T
I
Q
-------
R
R
--
M
Q
K
L
V
E
E
A
P
S
P
I
-
L
-
D
D
E
T
R
R
E
M
G
-
N
-----
A
A
V
R
---
A
A
K
A
V
N
Y
E
--
N
A
G
T
I
E
F
I
Y
D
L
N
D
N
K
F
Y
F
M
E
M
N
T
R
I
Q
V
E
H
--
P
-
V
T
-
E
M
V
-
T
G
I
D
L
V
K
L
Q
L
Q
V
A
M
G
-
D
V
L
P
Y
K
Q
E
D
I
-----------
K
L
T
G
--
H
A
-
I
-
E
F
R
------
I
N
AENPYKN
F
------
M
---
P
S
P
G
K
I
--
E
Q
---------
Y
--
L
A
P
----
G
G
-----
Y
--
G
V
--
R
I
E
S
-
A
C
Y
T
N
Y
T
I
P
P
-
Y
--
Y
-----
D
S
M
V
A
K
L
I
I
H
--
E
P
T
R
D
E
A
I
M
A
G
I
R
A
L
S
E
F
V
V
L
-------
45
HHSearch
50.16
18%
12
- C2 -
3OUZ
15
?
A:
[4-417]
-------
M
E
I
K
S
I
L
I
A
N
R
--
G
E
I
A
L
R
A
L
R
T
I
K
E
M
-
G
K
K
-----
A
I
C
V
Y
S
E
A
D
K
D
A
L
Y
-----------------
L
K
Y
A
D
A
S
I
C
I
G
K
----
A
------
R
S
S
E
S
Y
L
N
I
P
A
I
I
A
A
A
E
I
-
A
E
A
D
A
I
F
P
-
G
Y
G
F
L
-
S
--
E
N
Q
N
F
V
E
I
C
A
K
H
N
I
K
F
I
G
-
P
S
V
E
A
M
N
L
M
S
D
K
S
K
A
K
Q
V
M
-
Q
R
A
G
V
P
V
I
P
G
S
--
D
G
AL-
A
G
A
E
A
A
K
K
L
A
K
E
I
G
Y
P
V
I
L
K
A
A
A
G
G
G
G
R
G
M
R
V
V
---
E
N
E
K
D
L
E
K
A
Y
W
S
A
E
S
E
A
M
T
-
A
F
G
D
-----
G
T
M
Y
M
E
K
Y
I
Q
-
N
-
P
R
-----------
H
------------
I
E
V
Q
V
I
G
D
S
F
G
N
V
I
H
V
G
E
R
D
C
S
M
Q
-------
R
R
--
H
Q
K
L
I
E
E
S
P
A
I
L
-
L
-
D
E
K
T
R
T
R
L
H
-
E
-----
T
A
I
K
---
A
A
K
A
I
G
Y
E
--
G
A
G
T
F
E
F
L
V
D
K
-
N
L
D
F
Y
F
I
E
M
N
T
R
L
Q
V
E
H
C
---
V
S
-
E
M
V
-
S
G
I
D
I
I
E
Q
M
I
K
V
A
E
G
-
Y
A
L
P
S
Q
E
S
I
K
------------
L
N
G
--
H
S
I
E
-
C
R
I
T
AEDSK
T
--------
F
------
L
---
P
S
P
G
K
I
--
T
K
---------
Y
--
I
P
P
----
A
G
-----
R
-
N
V
---
R
M
E
S
-
H
C
Y
Q
D
Y
S
V
P
A
--
Y
-
Y
-----
D
S
M
I
G
K
L
V
V
W
--
A
E
D
R
N
K
A
I
A
K
M
K
V
A
L
D
E
L
L
I
S
G
I
-----
51
HHSearch
49.33
14%
-1
- C2 -
4MV4
5
ACCC_HAEIN
A:
[21-434]
--------
M
L
E
K
V
V
I
A
N
R
-
G
-
E
I
A
L
R
I
L
R
A
C
K
E
L
-
G
I
K
-----
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
-----------------
L
L
A
D
E
T
I
C
I
G
P
----
A
P
S
AKSY
L
N
I
P
A
I
I
--
A
A
----
A
E
V
-
T
G
A
D
A
I
H
P
-
G
Y
G
F
L
-
S
--
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
FI
G
-
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
-
K
K
A
G
V
P
C
V
P
G
S
--
D
G
PVS
N
D
I
A
K
N
K
E
I
A
K
R
I
G
Y
P
I
I
I
K
A
S
G
G
G
G
---
M
R
V
V
---
R
S
E
D
A
L
E
E
S
I
A
M
T
K
A
E
A
K
A
-
A
F
N
N
-----
D
M
V
Y
M
E
K
Y
L
E
-
N
-
P
R
-----------
H
------------
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
-------
R
R
--
H
Q
K
V
V
E
E
A
P
A
P
G
-
I
-
T
E
E
V
R
R
D
I
G
-
S
-----
R
C
A
N
---
A
C
V
E
I
G
Y
R
--
G
A
G
T
F
E
F
L
Y
E
N
--
G
E
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
--
P
-
V
T
-
E
M
I
-
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
-
L
P
I
S
F
K
Q
E
D
I
--
K
---------
V
K
G
--
H
A
-
M
-
E
C
R
------
I
--------
N
AEDPKT
F
-
L
-
P
S
P
G
K
V
--
N
H
---------
L
--
H
S
P
----
G
G
L
------
G
V
---
R
W
D
S
-
H
V
Y
G
G
Y
T
V
P
P
-
H
--
Y
-----
D
S
M
I
A
K
L
I
T
Y
--
G
D
T
R
E
V
A
I
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
-----
34
HHSearch
48.16
19%
3
- C2 -
4DIM
-
?
A:
[3-399]
--------
D
N
K
R
L
L
I
L
G
A
G
-
R
-
G
Q
L
G
L
Y
K
A
A
K
E
L
-
G
I
H
-----
T
I
A
G
T
M
P
N
A
H
-
K
P
C
-----------------
L
N
L
A
D
E
I
S
Y
M
D
I
-----------
S
N
P
D
E
V
E
--
Q
K
V
----
K
D
-
L
N
L
D
G
A
A
T
C
C
L
D
T
G
-
I
--
V
--
S
L
A
R
I
C
D
K
E
N
L
V
--
G
-
L
N
E
E
A
A
I
M
C
G
D
K
Y
K
M
K
E
A
F
-
K
K
Y
N
V
N
T
A
R
H
F
--
V
V
---
R
N
E
N
E
L
K
N
A
L
E
N
L
K
L
P
V
I
V
K
A
T
D
L
-----
I
Y
I
A
---
K
K
E
E
E
A
I
D
G
F
N
E
T
M
N
L
-----
T
K
R
-----
D
Y
C
I
V
E
E
F
I
E
-
G
-
Y
------------
E
------------
F
G
A
Q
A
F
V
Y
-
K
N
D
V
L
F
V
M
P
H
G
D
E
T
Y
M
S
-----
H
T
--
A
V
P
V
G
H
Y
V
P
L
-
D
-
V
-
K
D
D
I
I
E
K
T
K
-
T
-----
E
V
K
K
---
A
I
K
A
L
G
L
N
-
N
C
A
V
N
V
D
M
I
L
K
D
--
N
E
V
Y
I
I
E
L
T
G
R
V
G
A
N
C
L
P
E
-
L
V
-
E
I
N
-
Y
G
I
E
Y
Y
K
M
I
A
S
M
A
I
S
-
E
N
P
L
V
F
W
S
Q
K
---
S
K
------
E
N
K
A
--
G
L
-
A
-
R
M
I
------
I
--------
E
--------
T
-
E
K
S
G
I
L
--
K
E
---------
I
--
L
N
S
----
N
--
A
K
-
D
D
-
D
I
V
--
E
I
T
F
-
F
K
E
E
N
D
E
I
K
K
-
F
E
N
S
-----
N
D
C
I
G
Q
I
I
V
K
--
E
E
T
L
D
K
C
K
D
K
L
D
V
I
I
N
N
I
N
I
I
L
------
41
HHSearch
47.71
15%
-13
- C2 -
1KJQ
16
PURT_ECOLI
A:
[10-390]
--------
A
A
T
R
V
M
L
L
G
S
-
G
-
E
L
G
K
E
V
A
I
E
C
Q
R
L
-
G
V
E
-----
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
-------------------
V
A
H
R
S
H
V
I
N
M
-----------
L
D
G
D
A
L
R
--
R
V
V
----
E
L
-
E
K
P
H
Y
I
V
P
-
E
I
E
A
I
-
A
--
T
--
D
M
L
I
Q
L
E
E
E
G
L
N
--
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
--
F
A
---
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
---
K
G
Q
T
F
I
---
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
---
A
G
A
-----
G
R
V
I
V
E
G
V
V
K
F
D
-
F
------------
E
------------
I
T
L
L
T
V
S
A
V
D
G
V
H
F
C
A
P
V
G
H
R
Q
E
D
-------
G
----
D
Y
R
E
S
W
Q
P
Q
-
Q
-
M
-
S
P
L
A
L
E
R
A
Q
-
E
-----
I
A
R
K
---
V
V
L
A
L
G
G
--
Y
G
L
F
G
V
E
L
F
V
C
G
--
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
-
L
I
---
S
-
Q
D
L
S
E
F
A
L
H
V
R
A
F
L
G
-
L
P
V
G
G
I
R
Q
Y
--------------
G
P
--
A
A
-
S
--
A
V
------
I
--------
L
------
P
---
Q
L
T
S
Q
N
--
V
T
---------
F
--
D
N
V
----
Q
N
A
V
---
G
-
A
D
L
--
Q
I
R
L
-
F
---
G
K
P
E
I
---
D
-
G
-----
S
R
R
L
G
V
A
L
A
T
--
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
-------
49
HHSearch
47.09
17%
4
- C2 -
3U9T
-
?
A:
[48-483]
--------
S
I
Q
R
L
L
V
A
N
R
--
G
E
I
A
C
R
V
M
R
S
A
R
A
L
-
G
I
G
-----
S
V
A
V
H
S
D
I
D
R
H
A
R
H
V
-----------------
A
E
A
D
I
A
V
D
L
G
G
AKPA
D
S
Y
----
L
R
G
D
R
I
I
--
A
A
A
----
L
A
-
S
G
A
Q
A
I
H
P
-
G
Y
G
F
L
-
S
EN
A
--
D
F
A
R
A
C
E
E
A
G
L
L
FL
G
-
P
P
A
A
A
I
D
A
M
G
S
K
S
A
A
K
A
L
M
-
E
E
A
G
V
P
L
V
P
G
Y
--
H
G
E
A
-
Q
D
L
E
T
F
R
R
E
A
G
R
I
G
Y
P
V
L
L
K
A
A
A
------
M
K
V
V
---
E
R
E
A
E
L
A
E
A
L
S
S
A
Q
R
--------------
A
R
M
L
V
E
K
Y
L
L
-
K
-
P
R
-----------
H
------------
V
E
I
Q
V
F
A
D
R
H
G
H
C
L
Y
L
N
E
R
D
C
S
I
Q
-------
R
R
--
H
Q
K
V
V
E
E
A
P
A
P
G
-
L
-
G
A
E
L
R
R
A
M
G
-
E
-----
A
A
V
R
---
A
A
Q
A
I
G
Y
--
V
G
A
G
T
V
E
F
L
L
D
E
-
R
G
Q
F
F
F
M
E
M
N
T
R
L
Q
V
E
H
P
---
V
T
-
E
A
I
-
T
G
L
D
L
V
A
W
Q
I
R
V
A
R
G
-
E
A
L
P
L
T
Q
E
Q
V
-----------
P
L
N
G
--
H
A
-
I
-
E
V
R
------
L
--------
Y
------
A
-
E
-
D
P
E
G
D
F
--
L
P
---------
A
--
S
G
R
LM
L
Y
R
E
A
A
A
-
G
P
-
G
R
---
R
V
D
S
-
G
V
R
E
G
D
E
V
S
P
-
F
--
Y
-----
D
P
M
L
A
K
L
I
A
W
--
G
E
T
R
E
E
A
R
Q
R
L
L
A
M
L
A
E
T
S
V
G
-------
29
Fugue
47.06
15%
23
* C2 *
1EZ1
7
PURT_ECOLI
A:
[2-392]
T
L
L
G
T
AL
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
---
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
----
A
---------------------
I
A
T
-
D
M
L
I
Q
L
E
E
-
E
G
L
N
V
-
V
--
P
-------------------
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
--
F
A
---
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
---
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
A
----------
G
R
V
I
V
E
G
V
V
K
-------------------------
F
D
F
E
I
T
L
L
T
V
S
A
-
V
D
G
V
H
F
C
A
P
V
G
H
R
Q
E
-------
D
G
--
D
Y
R
E
S
W
Q
-
P
Q
-
Q
-
M
-
S
P
L
A
L
E
R
A
Q
-
E
-----
I
A
R
K
---
V
V
L
A
L
G
G
Y
-
G
-
L
F
G
V
E
L
-
F
V
C
-
G
D
E
V
I
F
S
E
V
S
P
R
P
H
--
D
T
G
M
-
V
T
-
L
I
S
-
Q
D
L
S
E
F
A
L
H
V
R
A
F
L
------------------------------------
G
------
L
--------
P
------
V
-
G
-
G
I
R
Q
Y
G
--
P
A
---------
A
S
A
V
I
L
----
P
Q
L
T
S
-
Q
N
-
V
T
F
--
D
N
V
Q
-
N
A
V
-
G
A
D
L
Q
I
-
R
L
-
F
GKPEI
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
G
------
6
PsiBlast_PDB
46.51
26%
-84
- C2 -
4DIM
-
?
A:
[81-293]
-----------------------------------------------------------------------------------------------------------------------------------
I
--
V
--
S
L
A
R
I
C
D
K
E
N
L
V
--
G
-
L
N
E
E
A
A
I
M
C
G
D
K
Y
K
M
K
E
A
F
-
K
K
Y
N
V
N
T
A
R
H
F
--
V
V
---
R
N
E
N
E
L
K
N
A
L
E
N
L
K
L
P
V
I
V
K
A
T
D
L
-----
I
Y
I
A
---
K
K
E
E
E
A
I
D
G
F
N
E
T
M
N
----------
L
T
K
R
D
Y
C
I
V
E
E
F
I
E
-
G
--------------
Y
E
F
G
A
Q
A
F
V
Y
K
N
D
V
L
F
V
M
P
H
G
-
D
E
T
Y
M
S
---
H
T
A
V
P
---------------
V
G
H
Y
V
P
L
-
D
-
V
-
K
D
D
I
I
E
K
T
K
-
T
-----
E
V
K
K
---
A
I
K
A
L
G
L
N
-
N
C
A
V
N
V
D
-
M
I
L
K
-
D
N
E
V
Y
I
I
E
L
T
G
R
-
V
G
A
N
C
L
P
-
E
L
-
V
E
I
N
Y
G
I
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
46.08
17%
36
- C2 -
1ULZ
-
?
A:
[1-413]
--------
M
V
N
K
V
L
V
A
N
R
-
G
-
E
I
A
V
R
I
I
R
A
C
K
E
L
-
G
I
P
-----
T
V
A
I
Y
N
E
V
E
S
T
A
R
H
V
-----------------
K
L
A
D
E
A
Y
M
I
G
T
-----------
D
P
L
D
T
Y
L
N
K
Q
R
I
I
N
L
A
L
E
-
V
G
A
D
A
I
H
P
-
G
Y
G
F
L
-
A
--
E
N
A
E
F
A
K
M
C
E
E
A
G
I
T
F
I
G
-
P
H
W
K
V
I
E
L
M
G
D
K
A
R
S
K
E
V
M
-
K
K
A
G
V
P
V
V
P
G
S
DG
V
L
---
K
S
L
E
E
A
K
A
L
A
R
E
I
G
Y
P
V
L
L
K
A
T
A
G
G
G
G
R
G
I
R
I
C
---
R
N
E
E
E
L
V
K
N
Y
E
Q
A
S
R
E
A
E
------
K
A
F
G
R
G
D
L
L
L
E
K
F
I
E
-
N
-
P
------------
K
H
-----------
I
E
Y
Q
V
L
G
D
K
H
G
N
V
I
H
L
G
E
R
D
C
S
I
Q
-------
R
R
--
N
Q
K
L
V
E
I
A
P
S
-
L
I
L
-
T
P
E
K
R
E
Y
Y
G
-
N
-----
I
V
T
K
---
A
A
K
E
I
G
Y
Y
--
N
A
G
T
M
E
F
I
A
D
Q
-
E
G
N
L
Y
F
I
E
M
N
T
R
I
Q
V
E
H
--
P
-
V
S
-
E
M
V
-
T
G
I
D
I
V
K
W
Q
I
K
I
A
A
G
-
E
P
L
T
I
K
Q
E
D
V
-----------
K
F
N
G
--
Y
A
-
I
-
E
C
R
------
I
--------
N
------
A
---
E
D
P
K
K
N
FA
P
S
---------
T
--
R
V
I
----
E
R
Y
-
Y
-
V
P
-
G
G
F
G
I
R
V
E
H
-
A
A
A
R
G
F
E
V
T
P
-
Y
--
Y
-----
D
S
M
I
A
K
L
I
T
W
--
A
P
T
W
D
E
A
V
E
R
M
R
A
A
L
E
T
Y
E
I
T
G
------
5
PsiBlast_PDB
45.24
28%
60
- C2 -
3VOT
6
?
A:
[59-315]
---------------------------------------------------------------------------------------------------
D
E
E
A
A
--
M
D
V
V
R
Q
T
F
V
E
F
P
F
D
G
V
M
T
-
L
F
E
P
A
-
L
--
P
--
F
T
A
K
A
A
E
A
L
N
L
P
--
G
-
L
P
F
T
T
M
E
N
C
R
N
K
N
K
T
R
S
I
L
-
Q
Q
N
G
L
N
T
P
V
F
H
--
E
F
---
H
T
L
A
D
L
E
N
--
R
K
L
S
Y
P
L
V
V
K
P
V
N
-----
G
V
V
R
V
DD
R
K
E
L
E
E
A
V
R
K
V
E
A
V
N
Q
--
R
D
L
N
--
R
F
V
H
G
K
T
G
I
V
A
E
Q
F
I
D
-
G
-------------------------
P
E
F
A
I
E
T
L
S
I
-
Q
G
N
V
H
V
L
S
I
G
Y
K
G
N
S
-------
K
G
PF
F
E
E
G
V
Y
I
A
P
A
-
Q
-
L
-
K
E
E
T
R
L
A
I
V
-
K
-----
E
V
T
G
---
A
V
S
A
L
G
I
H
-
Q
G
P
A
H
T
E
L
R
L
D
K
-
D
G
T
P
Y
V
I
E
V
G
A
R
I
G
G
S
G
V
S
H
-
Y
I
V
K
E
S
-
T
G
I
N
F
M
Q
L
V
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
45.03
14%
5
- C2 -
3MJF
12
PUR2_YERPE
A:
[3-414]
---------
A
M
N
I
L
I
I
G
N
G
G
-
R
E
H
A
L
G
W
K
A
A
Q
S
P
-
L
A
D
-----
K
I
Y
V
A
P
G
N
A
G
T
A
L
E
-------------------
P
T
L
E
N
V
D
I
A
A
-----------
T
D
I
A
G
L
L
--
A
F
A
----
Q
S
-
H
D
I
G
L
T
I
V
-
G
P
E
A
P
-
L
--
V
I
-
G
V
V
D
A
F
R
A
A
G
L
A
I
F
G
-
P
T
Q
A
A
A
Q
L
E
G
S
K
A
F
T
K
D
F
L
-
A
R
H
N
I
P
S
A
E
Y
Q
--
N
F
---
T
D
V
E
A
A
L
A
Y
V
R
Q
K
G
A
P
I
V
I
K
A
D
G
L
A
A
G
K
G
V
I
V
A
---
M
T
Q
E
E
A
E
T
A
V
N
D
M
L
A
G
N
A
-
F
G
D
A
G
-----
H
R
I
V
V
E
E
F
L
D
-
G
-
E
------------
E
------------
A
S
F
I
V
M
V
D
-
G
E
N
V
L
P
M
A
T
S
Q
D
H
K
R
VGDGDTG
P
N
--
T
G
G
M
G
A
Y
S
P
A
-
P
-
V
V
T
D
D
V
H
Q
R
V
M
-
D
QV
I
W
P
T
V
R
G
---
M
A
A
E
G
N
I
Y
-
T
G
F
L
Y
A
G
L
M
I
S
A
-
D
G
Q
P
K
V
I
E
F
N
C
R
F
G
D
P
E
T
Q
--
P
I
-
M
L
R
-
M
R
S
D
L
V
E
L
C
L
A
G
T
Q
G
-
K
L
N
E
K
T
S
D
W
D
-
E
R
P
--------
S
L
G
V
V
L
A
-
A
-
G
G
Y
------
P
--------
A
------
D
---
Y
R
Q
G
D
V
-------------
I
--
H
G
L
----
P
Q
Q
E
V
K
D
G
-
K
V
F
--
H
A
G
T
-
K
L
N
G
N
H
E
V
V
---
T
-
N
-----
G
G
R
V
L
C
V
T
A
L
--
G
E
T
V
A
Q
A
Q
Q
Y
A
Y
Q
L
A
E
G
I
Q
W
E
-------
48
HHSearch
44.39
16%
19
- C2 -
2YW2
2
PUR2_AQUAE
A:
[1-405]
----------
M
K
V
L
V
V
G
N
-
G
G
R
E
H
A
I
A
W
K
V
A
Q
S
P
-
L
V
K
-----
E
L
Y
V
A
K
-
G
N
A
G
I
W
E
-------------------
I
A
K
R
V
-
D
I
S
P
-----------
T
D
V
E
K
L
A
--
E
F
A
----
K
N
-
E
G
V
D
F
T
I
V
-
G
P
E
A
P
L
V
--
E
--
G
I
V
D
E
F
E
K
R
G
L
K
I
F
G
-
P
N
K
E
A
A
K
L
E
G
S
K
A
F
A
K
T
F
M
-
K
K
Y
G
I
P
T
A
R
Y
E
--
V
F
---
T
D
F
E
K
A
K
E
Y
V
E
K
V
G
A
P
I
V
V
K
A
D
G
L
A
A
G
K
G
A
V
V
C
---
E
T
V
E
K
A
I
E
T
L
D
R
F
L
N
K
K
-
I
F
G
K
S
S
-----
E
R
V
V
I
E
E
F
L
E
-
G
-
E
------------
E
------------
A
S
Y
I
V
M
I
N
-
G
D
R
Y
V
P
L
P
T
S
Q
D
H
K
R
LLDEDKG
P
N
--
T
G
G
M
G
A
Y
S
P
T
-
P
-
V
I
N
E
E
V
E
K
R
I
R
E
E
-----
I
V
E
R
V
I
K
G
L
K
E
E
G
I
Y
Y
R
G
F
L
Y
A
G
L
M
I
T
K
--
E
G
P
K
V
L
E
F
N
V
R
L
G
D
P
E
A
Q
--
P
I
-
L
M
R
-
V
K
N
D
F
L
E
T
L
L
N
F
Y
E
G
-
K
D
V
H
I
K
E
D
E
R
------------
Y
A
L
--
D
V
-
V
L
A
S
R
------
G
--------
Y
--------
P
-
E
K
P
E
T
G
--
K
I
---------
I
--
H
G
L
----
D
Y
L
K
S
-
M
E
-
D
V
V
--
V
F
H
A
G
T
K
K
E
G
N
F
T
V
T
----
S
-----
G
G
R
V
L
N
V
C
A
Y
--
G
K
T
L
K
E
A
K
E
R
A
Y
E
A
I
R
Y
V
C
F
--------