@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0003: (2016-04-18 )
MYVRHLGLRDFRSWACVDLELHPGRTVFVGPNGYGKTNLIEALWYSTTLGSHRVSADLPLIRVGTDRAVISTIVVNDGRECAVDLEIATGRVNKARLNRSSVRSTRDVVGVLRAVLFAPEDLGLVRGDPADRRRYLDDLAIVRRPAIAAVRAEYERVLRQRTALLKSVPGARYRGDRGVFDTLEVWDSRLAEHGAELVAARIDLVNQLAPEVKKAYQLLAPESRSASIGYRASMDVTGPSEQSDIDRQLLAARLLAALAARRDAELERGVCLVGPHRDDLILRLGDQPAKGFASHGEAWSLAVALRLAAYQLLRVDGGEPVLLLDDVFAELDVMRRRALATAAESAEQVLVTAAVLEDIPAGWDARRVHIDVRADDTGSMSVVLP
Atome Classification :
(20 SA)
----.........10....-.--...--20....-....30......--..40....---...--.50....--.--....---------------------------60......------..70-..-......80........90........100-----.----...-...110.......120-------....-------..-.--------.130.......140..----.....150.---......160.......170.......180.......190...-----....200...--....210....--------..---.220.....-..230.......240--.......250..------.....260.--...-----...270..---.....-----280....----.----------------..290-.........--------------------------------300-........310...-....-320.......330.......340....---.-..350.....-------..360.......370.......380...-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----M
Y
V
R
HLG
L
R
D
FR
S
W
A
-
C
--
V
D
L
--
E
LHPG
R
-
T
V
F
VGPNGYG
K
T
--
N
L
I
E
A
L
W
Y---STT--LG-SHRV--S--ADL
P
---------------------------
L
I
R
VGTD
R
------
A
V
I
S
-
T
I
-
V
VNDGR
E
C
A
V
D
L
E
IATGRV
N
K
A
RL
N
R
S
S
V
-----
R
----
S
T
R
-
D
V
V
G
V
L
R
A
V
LFAPED--------LGLV-------RG-
D
--------
P
A
D
R
R
R
Y
L
D
D
L
A
I
VRR----
P
A
I
A
A
V
R
A
E
---
Y
E
R
V
L
R
Q
R
T
A
L
L
K
SVPGARYRGDRGV
F
D
T
L
E
V
W
D
S
R
L
A
EH
G
A
-----
E
L
V
A
A
R
I
D
L
V
--
N
Q
L
A
P
E
V
K
K
A
Y
--------
Q
L---LAPESRSAS-IG
Y
R
A
SMDVTGPSEQ--
S
D
I
D
R
Q
L
L
A
A
R
L
------
L
A
A
L
A
A
RR
D
--
A
E
L
-----ER
G
V
C
L
VG---PHRD
D
-----
L
I
L
RLGD----Q----------------PA
K
---
G
FASHG
E
A
W
--------------------------------
S
L
--
A
V
A
L
R
L
A
A
Y
Q
L
LRV-DGG
E
-
P
V
L
L
L
D
D
V
F
A
E
L
D
V
M
R
R
R
A
L
A
T
A
A
ES
A
---
E
-
Q
V
L
V
T
A
A
V
L
E
-------DIPAGW
D
A
R
R
V
H
I
D
V
RADDTG
S
M
S
V
VLP-------
29
Fugue
95.19
33%
-83
- C2 -
2O5V
1
RECF_DEIRA
A:
[2-359]
--GD
V
R
L
S
A
L
S
T
L
N
Y
R
N
L
A
-
P
--
G
T
L
--
N
F
P
E
G
V
-
T
G
I
Y
G
E
N
G
A
G
K
T
--
N
L
L
E
A
A
Y
L
---
A
L
T
---
G
-
Q
T
D
A
--
P
--
R
I
E
Q
---------------------------
L
I
Q
A
G
E
T
E
------
A
Y
V
R
-
A
D
-
L
Q
Q
G
G
S
L
S
I
Q
E
V
G
L
G
R
G
---
R
R
Q
L
K
V
D
G
V
-----
R
----
A
R
T
-
G
D
L
P
R
G
G
A
V
W
I
R
P
E
D
--------
S
E
L
V
-------
F
G
-
P
--------
P
S
G
R
R
A
Y
L
D
S
L
L
S
R
L
S
----
A
R
Y
G
E
Q
L
S
R
---
Y
E
R
T
V
S
Q
R
N
A
A
L
R
----------
G
G
E
E
W
A
M
H
V
W
D
D
V
L
L
K
L
G
T
-----
E
I
M
L
F
R
R
R
A
L
--
T
R
L
D
E
L
A
R
E
A
N
--------
A
Q
---
L
G
S
R
-
K
T
L
A
-
L
T
L
T
E
S
T
S
-----------------
P
E
T
Y
------
A
A
D
L
R
G
R
R
A
--
E
E
L
-----
A
R
G
S
T
V
T
G
---
P
H
R
D
D
-----
L
L
L
T
L
G
D
----
F
----------------
P
A
S
---
D
Y
A
S
R
G
E
G
R
--------------------------------
T
V
--
A
L
A
L
R
R
A
E
L
E
L
L
R
E
-
K
F
G
E
D
P
V
L
L
L
D
D
F
T
A
E
L
D
P
H
R
R
Q
Y
L
L
D
L
A
A
S
V
---
P
-
Q
A
I
V
T
G
T
E
L
A
-------
P
G
A
A
L
T
L
R
A
Q
A
G
R
F
T
P
V
A
D
E
E
M
Q
A
E
G
T
A
-------
39
HHSearch
94.00
34%
-93
- C2 -
2O5V
1
RECF_DEIRA
A:
[4-333]
----
V
R
L
S
A
L
S
T
L
N
Y
R
N
L
A
-
P
--
G
T
L
--
N
F
P
E
G
V
-
T
G
I
Y
G
E
N
G
A
G
K
T
--
N
L
L
E
A
A
Y
L
---
A
L
T
--
G
Q
-
T
D
A
P
-----
R
I
E
Q
---------------------------
L
I
Q
A
G
E
T
E
------
A
Y
V
R
-
A
D
-
L
Q
Q
G
G
S
L
S
I
Q
E
V
G
L
G
R
G
-
R
R
Q
L
K
V
D
G
-
V
R
-----
A
----
R
T
G
-
D
L
P
-
R
G
G
A
V
W
I
R
P
E
D
--------
S
E
L
V
-------
F
G
-
P
--------
P
S
G
R
R
A
Y
L
D
S
L
L
S
R
L
S
----
A
R
Y
G
E
Q
L
S
R
---
Y
E
R
T
V
S
Q
R
N
A
A
L
R
G
G
E
E
----------
W
A
M
H
V
W
D
D
V
L
L
K
L
G
T
-----
E
I
M
L
F
R
R
R
A
L
--
T
R
L
D
E
L
A
R
E
A
N
--------
A
Q
---
L
G
S
R
-
K
T
L
A
-
L
T
L
T
E
S
T
S
P
-----------------
E
T
Y
------
A
A
D
L
R
G
R
R
A
--
E
E
L
-----
A
R
G
S
T
V
T
G
---
P
H
R
D
D
-----
L
L
L
T
L
G
D
----
F
----------------
P
A
S
---
D
Y
A
S
R
G
E
G
R
--------------------------------
T
V
--
A
L
A
L
R
R
A
E
L
E
L
L
R
E
K
F
G
E
D
-
P
V
L
L
L
D
D
F
T
A
E
L
D
P
H
R
R
Q
Y
L
L
D
L
A
A
S
V
---
P
-
Q
A
I
V
T
G
T
E
L
A
-------
P
G
---------------------------------
1
PsiBlast_PDB
92.02
34%
-86
- C2 -
2O5V
1
RECF_DEIRA
A:
[13-330]
-------------
N
Y
R
N
L
A
-
P
--
G
T
L
--
N
F
P
E
G
V
-
T
G
I
Y
G
E
N
G
A
G
K
T
--
N
L
L
E
A
A
Y
L
---
A
L
T
---
G
-
Q
T
D
A
--
P
--
R
I
E
Q
---------------------------
L
I
Q
A
G
E
T
E
------
A
Y
V
R
-
A
D
-
L
Q
Q
G
G
S
L
S
I
Q
E
V
G
L
G
R
G
R
---
R
Q
L
K
V
D
G
V
-----
R
----
A
R
T
-
G
D
L
P
R
G
G
A
V
W
I
R
P
E
D
--------
S
E
L
V
-------
F
G
-
P
--------
P
S
G
R
R
A
Y
L
D
S
L
L
S
R
L
S
----
A
R
Y
G
E
Q
L
S
R
---
Y
E
R
T
V
S
Q
R
N
A
A
L
R
G
----------
G
E
E
W
A
M
H
V
W
D
D
V
L
L
K
L
G
T
-----
E
I
M
L
F
R
R
R
A
L
--
T
R
L
D
E
L
A
R
E
A
--------------------
N
A
Q
-
L
G
S
R
K
T
L
A
L
T
L
T
E
S
T
--
S
-------
P
E
T
Y
------
A
A
D
L
R
G
R
R
A
--
E
E
L
-----
A
R
G
S
T
V
T
G
---
P
H
R
D
D
-----
L
L
L
T
L
G
D
----
F
----------------
P
A
S
---
D
Y
A
S
R
G
E
G
R
--------------------------------
T
V
--
A
L
A
L
R
R
A
E
L
E
L
L
R
E
-
K
F
G
E
D
P
V
L
L
L
D
D
F
T
A
E
L
D
P
H
R
R
Q
Y
L
L
D
L
A
A
S
V
---
P
-
Q
A
I
V
T
G
T
E
L
-------------------------------------------
19
PsiBlast_PDB
78.38
22%
-97
- C2 -
3QKU
2
?
A:
[1-318]
----
M
K
L
E
R
V
T
V
K
N
F
R
S
H
S
-
D
--
T
V
V
--
E
F
K
E
G
I
-
N
L
I
I
G
Q
N
G
S
G
K
S
--
S
L
L
D
A
I
L
V
---
G
L
Y
WP
L
R
-
I
K
D
I
--
K
--
K
D
-
E
---------------------------
F
T
K
V
G
A
R
D
------
T
Y
I
D
-
L
I
-
F
E
K
D
G
T
K
Y
R
I
T
R
R
F
L
K
G
------
Y
S
S
G
E
I
-----
H
----
A
M
K
-
R
L
V
G
N
E
W
K
H
V
T
E
P
S
S
K
A
------
I
S
A
F
-------
M
E
-
K
--------
L
I
P
Y
N
I
F
L
N
A
I
Y
I
-
R
Q
----
G
Q
I
D
A
I
L
E
S
D
E
A
R
E
K
V
V
R
E
V
L
N
L
D
K
F
E
T
A
--
Y
K
K
L
S
E
L
K
K
T
I
---
N
N
R
I
K
E
Y
G
G
SGGIK
D
L
E
K
A
K
-
D
F
T
--
E
E
L
I
E
K
V
K
K
-
Y
--------
K
A
---
L
A
R
E
A
A
L
S
K
-
I
G
E
---------------------
L
A
S
E
I
------
F
A
E
F
T
E
G
K
Y
--
S
E
V
V
V
R
A
E
E
N
K
V
R
L
---------------
F
V
V
W
E
G
K
----
E
----------------
R
P
L
---
T
F
L
S
G
G
E
R
I
--------------------------------
A
L
--
G
L
A
F
R
L
A
M
S
--
L
Y
L
-
A
G
E
I
-
S
L
L
I
L
D
E
P
T
P
Y
L
D
E
E
R
R
R
K
L
I
T
I
M
E
-----------------------------------------------------------
32
Fugue
70.37
20%
-71
- C2 -
1E69
-
?
A:
[1-1164]
----
M
R
L
K
K
L
Y
L
K
G
F
K
S
F
G
R
P
--
S
L
I
--
G
F
S
D
R
V
-
T
A
I
V
G
P
N
G
S
G
K
S
--
N
I
I
D
A
I
K
W
---
V
F
G
--
E
K
-
F
D
M
I
--
F
--
A
G
S
E
---------------------------
N
-
L
P
P
A
G
S
------
A
Y
V
E
-
L
V
-
F
E
E
N
G
E
E
I
T
V
A
R
E
L
K
R
T
G
E
N
T
Y
Y
L
N
G
S
P
V
-----
R
-----
L
K
-
D
I
R
D
R
F
A
G
T
G
L
G
V
D
F
--------
Y
S
I
V
-------
G
Q
-
G
--------
Q
I
D
R
I
V
-------------------------------------------------------------------------------------------------------------------------------------
N
--
A
Y
Q
R
V
N
E
S
F
N
R
F
------
I
S
L
L
F
F
G
G
E
--
G
R
L
-----
E
I
S
I
R
K
P
G
---
R
R
D
Q
K
-----
L
S
L
---------------------------------
L
S
G
G
E
K
A
--------------------------------
L
V
--
G
L
A
L
L
F
A
L
M
E
I
-----
K
P
S
-
P
F
Y
V
L
D
E
V
D
S
P
L
D
D
Y
N
A
E
R
F
K
R
L
L
K
E
N
---
S
-
K
H
T
Q
F
I
V
I
T
H
-------
N
K
I
V
M
E
A
A
D
L
L
H
G
V
T
M
V
N
G
V
S
A
I
V
P
V
E
V
-------
35
Fugue
57.06
20%
-30
- C2 -
4OC8
4
?
A:
[2-388]
----
T
F
F
T
G
E
T
L
G
Q
---------
V
D
L
--
I
V
D
A
V
Y
-
A
G
Y
K
T
E
R
G
-
G
M
A
--
D
P
L
V
P
L
V
G
---
V
S
R
--
Q
G
-
G
F
R
Y
R
G
T
--
R
E
R
P
---------------------------
T
L
L
V
L
T
S
N
----------------
L
A
E
P
E
W
P
D
Q
L
D
E
T
T
G
T
F
I
Y
Y
G
D
N
R
H
P
G
-----
R
LLHD
T
P
R
-
F
G
N
Q
L
L
R
Q
I
F
D
W
A
H
L
GQRHLV
P
P
I
L
V
F
-------
T
T
-
E
--------
A
T
G
R
T
F
R
F
R
G
L
A
V
P
G
S
----
P
A
L
A
A
T
E
-----------
D
L
V
A
L
W
K
T
T
E
G
Q
R
F
Q
N
Y
K
A
V
F
T
I
L
D
--
E
A
V
I
P
R
A
W
V
-----
H
A
V
G
R
G
E
T
----
S
G
L
A
P
V
A
W
N
A
W
--------
L
S
AG
G
I
R
P
L
M
A
P
R
S
-
L
L
V
R
S
K
A
E
Q
L
P
A
T
P
E
--
D
Q
A
L
I
E
V
I
R
Q
R
Y
K
EN
P
F
G
F
E
A
C
A
G
A
L
T
--
R
L
L
-----
L
P
D
V
A
R
L
D
L
T
R
P
W
R
D
G
G
R
D
G
I
G
R
L
R
I
G
Q
----
S
----------------
P
A
A
I
E
V
D
F
A
L
E
A
K
C
Y
--------------------------------
G
A
NN
A
V
G
V
K
E
V
S
R
L
I
S
R
I
-
K
H
R
E
-
F
G
V
L
V
T
T
S
Y
V
D
-----
R
Q
A
Y
Q
E
V
T
D
D
G
---
H
-
P
V
I
L
T
--
T
A
Q
-------
D
I
V
G
L
L
R
S
A
G
V
R
T
P
T
Q
V
D
A
W
L
D
G
I
T
A
S
V
-------
18
PsiBlast_PDB
56.59
21%
-78
- C2 -
5F3W
1
?
B:
[3-145]
----
M
I
L
K
E
I
R
M
N
N
F
K
S
H
V
-
N
--
S
R
I
--
K
F
E
K
G
I
-
V
A
I
I
G
E
N
G
S
G
K
S
--
S
I
F
E
A
V
F
F
---
A
L
F
--
G
A
-
G
S
N
F
--
N
--
Y
D
-
T
---------------------------
I
I
T
K
G
K
K
S
------
V
Y
V
E
-
L
D
-
F
E
V
N
G
N
N
Y
K
I
I
R
E
Y
D
S
G
R
-
G
G
A
K
L
Y
K
N
G
K
-----
P
----
Y
A
T
-
T
I
S
A
V
N
K
A
V
---
N
E
I
--------
L
G
V
----------------------
D
R
N
M
F
L
N
S
I
Y
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
56.39
21%
-78
- C2 -
5DNY
1
?
B:
[3-144]
----
M
I
L
K
E
I
R
M
N
N
F
K
S
H
V
-
N
--
S
R
I
--
K
F
E
K
G
I
-
V
A
I
I
G
E
N
G
S
G
K
S
--
S
I
F
E
A
V
F
F
---
A
L
F
--
G
A
-
G
S
N
F
--
N
--
Y
D
-
T
---------------------------
I
I
T
K
G
K
K
S
------
V
Y
V
E
-
L
D
-
F
E
V
N
G
N
N
Y
K
I
I
R
E
Y
D
S
G
R
-
G
G
A
K
L
Y
K
N
G
K
-----
P
----
Y
A
T
-
T
I
S
A
V
N
K
A
V
---
N
E
I
--------
L
G
V
----------------------
D
R
N
M
F
L
N
S
I
Y
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
55.67
21%
-78
- C2 -
3AUY
2
RAD50_METJA
A:
[3-136]
----
M
I
L
K
E
I
R
M
N
N
F
K
S
H
V
-
N
--
S
R
I
--
K
F
E
K
G
I
-
V
A
I
I
G
E
N
G
S
G
K
S
--
S
I
F
E
A
V
F
F
---
A
L
F
--
G
A
-
G
-
N
F
--
N
--
Y
D
-
T
---------------------------
I
I
T
K
G
K
K
S
------
V
Y
V
E
-
L
D
-
F
E
V
N
G
N
N
Y
K
I
I
R
E
Y
D
S
G
R
-
G
G
A
K
L
Y
K
N
G
K
-----
P
----
Y
A
T
-
T
I
S
A
V
N
K
A
V
---
N
E
I
--------
L
G
V
----------------------
D
R
N
M
F
L
N
S
I
Y
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
54.51
26%
-72
- C2 -
4I99
1
?
A:
[3-181]
-----
Y
I
E
K
L
E
L
K
G
F
K
S
Y
G
-
N
K
K
V
V
I
--
P
F
S
K
G
F
-
T
A
I
V
G
A
N
G
S
G
K
S
--
N
I
G
D
A
I
L
F
V
L
G
G
L
S
--
A
K
-
A
M
R
A
--
S
--
R
I
S
D
---------------------------
L
I
F
A
G
S
K
N
EPPAK
Y
A
E
V
A
-
I
Y
-
F
N
N
E
D
R
G
F
P
I
D
E
D
E
V
V
I
R
R
R
V
Y
P
D
G
R
S
S
Y
W
L
NG
R
R
----
A
T
R
S
E
I
L
D
I
L
T
A
A
M
I
S
P
D
G
--------
Y
N
I
V
L------
Q
G
-
D
I
T
K
F
I
K
MS
P
L
E
R
R
L
L
I
D
D
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
54.18
25%
-74
- C2 -
3KTA
2
SMC_PYRFU
A:
[3-169]
-----
Y
I
E
K
L
E
L
K
G
F
K
S
Y
G
-
N
K
K
V
V
I
--
P
F
S
K
G
F
-
T
A
I
V
G
A
N
G
S
G
K
S
--
N
I
G
D
A
I
L
F
V
L
G
G
L
S
--
A
K
-
A
M
R
A
--
S
--
R
I
S
D
---------------------------
L
I
F
A
G
S
--PAK
Y
--
A
E
V
A
-
I
Y
-
F
N
N
E
D
R
G
F
P
I
D
E
D
E
V
V
I
R
R
R
V
Y
P
D
G
R
S
S
Y
W
L
NG
R
R
----
A
T
R
S
E
I
L
D
I
L
T
A
A
M
I
S
P
D
G
--------
Y
N
I
V
L------
Q
G
-
D
ITKFIKMS
P
L
E
R
R
L
L
I
D
D
I
S
---------
G
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
53.92
25%
-68
- C2 -
1XEX
2
?
A:
[3-167]
-----
Y
I
E
K
L
E
L
K
G
F
K
S
Y
G
-
N
K
K
V
V
I
--
P
F
S
K
G
F
-
T
A
I
V
G
A
N
G
S
G
K
S
--
N
I
G
D
A
I
L
F
V
L
G
G
L
S
--
A
K
-
A
M
R
A
--
S
--
R
I
S
D
---------------------------
L
I
F
A
G
S
K
N
E
P
P
A
K
Y
A
E
V
A
-
I
Y
-
F
N
N
E
D
R
G
F
P
I
D
E
D
E
V
V
I
R
R
R
V
Y
P
D
G
R
S
S
Y
W
L
NGR
R
----
A
T
R
S
E
I
L
D
I
L
T
A
A
M
I
S
P
D
G
--------
Y
N
I
V
L------
Q
G
-
D
I
T
K
F
I
K
MS
P
L
E
R
R
L
L
I
D
D
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
53.74
21%
-76
- C2 -
3AUX
2
RAD50_METJA
A:
[3-155]
----
M
I
L
K
E
I
R
M
N
N
F
K
S
H
V
-
N
--
S
R
I
--
K
F
E
K
G
I
-
V
A
I
I
G
E
N
G
S
G
K
S
--
S
I
F
E
A
V
F
F
---
A
L
F
--
G
A
-
G
S
N
F
--
N
--
Y
D
-
T
---------------------------
I
I
T
K
G
K
K
S
------
V
Y
V
E
-
L
D
-
F
E
V
N
G
N
N
Y
K
I
I
R
E
Y
D
S
G
R
-
G
G
A
K
L
Y
K
N
G
K
-----
P
----
Y
A
T
-
T
I
S
A
V
N
K
A
V
---
N
E
I
--------
L
G
V
----------------------
D
R
N
M
F
L
N
S
I
Y
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
53.17
12%
-45
- C2 -
3EUJ
2
MUKB_HAEDU
A:
[3-483]
M
I
A
R
G
K
F
R
S
L
T
L
I
N
W
N
G
F
F
-
A
--
R
T
F
--
D
F
D
E
L
V
-
T
T
L
S
G
G
N
G
A
G
K
S
--
T
T
M
A
G
F
V
T
---
A
L
I
--
P
D
-
L
T
L
L
--
N
--
F
R
N
T
TEAGSTSSSRDKGLYGKLKA
G
V
C
Y
A
V
L
E
T
V
N
S
R
A
Q
------
R
I
I
T
-
G
V
-
R
L
Q
Q
I
A
G
R
D
K
K
V
D
I
R
P
F
S
L
Q
N
V
P
M
T
D
S
V
I
-----
S
----
L
F
T
-
E
Q
V
A
N
K
A
R
V
L
S
L
N
D
L
--------
K
E
K
F
E
ETA
V
T
F
K
P
-
Y
--------
H
S
I
T
D
Y
H
S
F
M
F
D
L
G
I
L
----
P
K
R
L
R
S
S
S
D
---
R
N
K
F
Y
K
L
I
E
A
S
L
Y
G
------
G
I
S
S
V
I
T
K
S
L
R
D
Y
L
L
P
E
N
S
G
V
R
-----
Q
A
F
Q
D
A
E
S
V
A
--
N
I
L
R
K
T
I
Q
R
E
Q
--------
N
R
---
I
L
Q
L
N
Q
G
L
Q
N
I
A
F
G
Q
V
K
G
V
R
L
V
V
N
I
--
R
D
T
H
S
I
L
L
N
A
L
S
------
D
Q
S
F
S
E
A
L
A
--
M
L
Y
-----
K
R
I
G
E
E
L
L
---
D
Y
R
N
Y
-----
L
D
L
E
V
E
T
----
L
R
GAYGWMRAESSALS
T
G
E
A
---
I
G
T
G
M
S
I
L
L
--------------------------------
M
V
--
V
Q
S
W
E
E
E
S
R
R
M
R
A
K
-
D
I
L
P
-
C
R
L
L
F
L
D
Q
A
A
R
L
D
A
M
S
I
N
T
L
F
E
L
C
E
R
L
---
D
M
Q
L
L
I
A
A
P
------------
E
N
I
S
P
E
R
G
T
T
Y
K
L
V
R
K
I
L
A
N
Q
E
Y
V
H
V
V
G
L
K
GFG
33
Fugue
52.96
12%
-42
- C2 -
4UX3
2
SMC3_YEAST
A:
[3-527]
-----
Y
I
K
R
V
I
I
K
G
F
K
T
Y
R
-
N
--
E
T
I
I
D
N
F
S
P
H
Q
-
N
V
I
I
G
S
N
G
S
G
K
S
--
N
F
F
A
A
I
R
F
---
V
L
S
DD
Y
S
-
N
L
K
R
--
E
--
E
R
Q
G
---------------------------
L
I
H
Q
G
S
G
G
------
S
V
M
S
A
S
V
-
E
I
V
I
R
R
T
V
G
L
K
K
D
--
D
Y
Q
L
N
D
R
N
V
T
K
G
D
I
-----
V
----
R
M
L
-
E
T
A
G
F
S
M
N
N
P
Y
N
I
V
P
--------
Q
G
K
I
-------
V
A
L
T
--------
N
A
K
D
K
E
R
L
Q
L
L
E
D
V
V
G
----
A
K
S
F
E
V
K
L
K
---
A
S
L
K
K
M
E
E
T
E
Q
K
K
I
Q
I
N
K
E
M
G
E
L
N
S
K
L
S
E
M
E
Q
E
R
K
E
L
E
K
Y
N
E
-----
L
E
R
N
R
K
I
Y
Q
F
--
T
L
Y
D
R
E
L
N
E
V
I
N
QMETSDQ
L
L
---
Q
R
L
N
D
M
N
T
E
-
I
S
G
L
K
N
V
N
K
R
A
F
E
N
F
--
K
K
F
N
E
R
R
K
D
L
A
E
------
R
A
S
E
L
D
E
S
K
--
D
S
I
-----
Q
D
L
I
V
K
L
K
---
Q
Q
K
V
N
-----
A
V
D
S
T
F
Q
----
K
----------------
V
S
E
---
N
F
E
A
V
F
E
R
L
V
PR
G
T
A
K
L
I
I
HS
I
S
V
S
F
N
SKQNEQLHVEQLS
G
G
Q
--
K
T
V
C
A
I
A
L
I
L
A
I
Q
M
-
V
D
P
A
-
S
F
Y
L
F
D
E
I
D
A
A
L
D
K
Q
Y
R
T
A
V
A
T
L
L
K
E
L
SKN
A
-
Q
F
I
C
T
T
F
R
T
D
MLQVA
D
K
F
F
R
V
K
Y
E
N
K
I
S
T
V
I
E
V
N
R
E
E
A
I
G
F
I
R
---------
16
PsiBlast_PDB
51.14
21%
-79
- C2 -
3AV0
3
RAD50_METJA
B:
[3-138]
----
M
I
L
K
E
I
R
M
N
N
F
K
S
H
V
-
N
--
S
R
I
--
K
F
E
K
G
I
-
V
A
I
I
G
E
N
G
S
G
K
S
--
S
I
F
E
A
V
F
F
---
A
L
F
--
G
A
-
G
S
N
F
--
N
--
Y
D
-
T
---------------------------
I
I
T
K
G
K
K
S
------
V
Y
V
E
-
L
D
-
F
E
V
N
G
N
N
Y
K
I
I
R
E
Y
D
S
G
R
-
G
G
A
K
L
Y
K
N
G
K
-----
P
----
Y
A
T
-
T
I
S
A
V
N
K
A
V
---
N
E
I
--------
L
G
V
----------------------
D
R
N
M
F
L
N
S
I
Y
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
51.08
25%
-69
- C2 -
1XEW
-
SMC_PYRFU
X:
[3-167]
-----
Y
I
E
K
L
E
L
K
G
F
K
S
Y
G
-
N
KK
V
V
I
--
P
F
S
K
G
F
-
T
A
I
V
G
A
N
G
S
G
K
S
--
N
I
G
D
A
I
L
F
VLG
G
L
S
--
A
K
-------------------------------------------------AKY---
A
E
V
A
-
I
Y
-
F
N
N
E
D
R
G
F
P
I
D
E
D
E
V
V
I
R
R
R
V
Y
P
D
G
R
S
S
Y
WLNGR
R
----
A
T
R
S
E
I
L
D
I
L
T
A
A
M
I
S
P
D
G
--------
Y
N
I
V
L------
Q
G
-
D
ITKFIKMS
P
L
E
R
R
L
L
I
D
D
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
47.86
15%
-67
- C2 -
1F2U
2
?
A:
[1-149]
----
M
K
L
E
R
V
T
V
K
N
F
R
S
H
S
-
D
--
T
V
V
--
E
F
K
E
G
I
-
N
L
I
I
G
Q
N
G
S
G
K
S
--
S
L
L
D
A
I
L
V
---
G
L
Y
--
W
P
L
R
I
K
D
--
I
--
K
K
D
E
---------------------------
F
T
K
V
G
A
R
D
------
T
Y
I
D
-
L
I
-
F
E
K
D
G
T
K
Y
R
I
T
R
R
F
L
K
G
Y
S
S
G
E
I
H
A
M
K
R
L
-----
V
----
G
N
E
-
W
K
H
V
T
E
P
S
S
K
A
I
S
A
F
--------
M
E
K
L
-------
I
-------------
P
Y
N
I
F
L
N
A
I
Y
I
R
Q
G
----
Q
I
D
A
I
L
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
46.74
30%
-55
- C2 -
1E69
-
?
A:
[1-1004]
----
M
R
L
K
K
L
Y
L
K
G
F
K
S
F
G
-
R
--
P
S
L
--
I
G
F
S
D
R
V
T
A
I
V
G
P
N
G
S
G
K
S
--
N
I
I
D
A
I
K
W
---
V
F
G
--------------
E
K
F
D
---------------------------
M
I
F
A
G
S
E
N
LPPAG
S
A
Y
V
E
-
L
V
-
F
E
E
N
G
E
E
I
T
V
A
R
E
L
K
R
T
G
E
N
T
Y
Y
L
N
G
S
P
V
-----
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
43.40
16%
-23
- C1 -
4X4W
12
TRNT1_HUMAN
A:
[1-409]
----
M
F
T
M
K
L
Q
S
P
E
F
Q
S
L
F
-----
T
E
--
G
L
K
S
L
T
-
E
L
F
V
K
E
N
H
E
L
R
I
A
G
G
A
V
R
D
L
L
N
---
G
V
K
--
P
Q
-
D
I
D
F
--
A
T
T
A
T
P
T
---------------------------
Q
M
K
E
M
F
Q
S
------
A
G
I
R
-
M
I
N
G
T
I
T
A
R
L
H
E
E
N
F
E
I
T
T
L
R
I
D
V
T
T
D
G
A
E
V
E
-----
F
----
T
T
D
-
W
Q
K
D
A
E
R
R
D
L
T
I
N
S
M
--------
F
L
G
F
-------
D
G
-
T
--------
L
F
D
Y
F
N
G
Y
E
D
L
K
N
K
K
V
RFVG
H
A
K
Q
R
I
Q
E
D
---
Y
L
R
I
L
R
Y
F
R
F
Y
G
R
I
V
D
K
P
G
D
H
D
P
E
T
L
E
A
I
A
E
N
A
K
G
L
A
G
I
S
G
E
-----
R
I
W
V
E
L
K
K
I
L
V
G
N
H
V
N
H
L
I
H
L
I
Y
--------
D
L
D--
V
A
P
Y
I
G
L
P
A
-
N
A
S
L
E
E
F
D
K
V
S
K
N
V
D
GF
S
P
K
P
V
T
L
L
A
S
L
F
KV
Q
D
D
-
V
T
K
L
D
L
R
L
K
IA
K
E
E
-----
K
N
L
G
L
F
I
V
---
K
N
R
K
D
-----
L
I
K
A
T
D
S
SDPL
K
----------------
P
Y
Q
---
D
F
I
I
D
S
D
A
T
--------------------------------
T
R
--
V
C
E
L
L
K
Y
Q
---------
G
E
-
H
C
L
L
K
E
M
Q
Q
W
S
I
P
P
F
P
V
S
G
H
D
I
R
K
V
G
I
---
S
-
S
G
K
E
I
G
A
L
L
Q
-------
Q
L
R
E
Q
W
K
K
S
G
Y
Q
M
E
-
K
D
E
L
L
S
Y
I
K
K
T
L
--------