@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0115: (2016-04-19 )
MAILRGRAPLRLGLGGGGTDVEPYSSQFGGRILSVTIDKYAYAFAERGTGDEIAFRSPDRDRAGQASIDDLASLEEDFPLHVAVYRRVIAEFNGGTPFPLQLATQVDAPPGSGLGSSSALVVAMLLTTCALIGSSPGPYELARLAWEIERVDLGMAGGWQDHYAAAFGGFNFMESRPNGEVVVNPLRIRREVIAELEASLLLYFGGVSRLSSEVIADQQRNVVERDADALAATHSICAEALEMKDLLVVGDIPGFADSLLRGWQAKKRTSTRISNPAIEHAYQVAQSSGMVAGKVSGAGGGGFLMMIVDPRRRIEVARSLERECGGSVAPCLFTKGGAVTWHIPESTAPVRRGVADAVASALGNAGILLCAGCVLATSHSTWRVPV
Atome Classification :
(20 SA)
-----------------.........10........20........30........40........50--........60.----.--.....---.-70---.--.-.-.-..----...80.---------------.......90.--------.--.-.....100.......110.......120.......130--.......140-------------.........150.......160......---.---170-.........180.----------------------......190.....------..200...--....210------------.-----.--------.-----------------------------------..------..220-----.-------------..------.-------------------------------------------.----------------..----230-----------....---...------..--240.......250-----.........260.......270...-----....280.....-.-.290.......300.......310---.......320.---.-.--....330.......340.......350.......360.......370.......380....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------MAILRGRA
P
L
R
L
GLGGGGTDVE
P
Y
S
S
QFG
G
R
I
L
S
V
T
I
D
K
Y
A
Y
A
F
AERGTGD--EIAFRSPDRDR----A--GQA
S
I
---
D
-
D
----
L
--
A
-
S
-
L
-
E
E----DF
P
L
H
V
---------------
A
V
Y
R
R
V
I
A
EF--------N--G-GTPF
P
L
Q
L
A
T
QVDAPPGSGLG
S
S
S
A
L
V
V
A
M
L
L
T
T
C
A
L
I--GSSP
G
P
Y
E
---------------
L
A
R
L
A
W
E
I
E
R
V
D
LGMAGGWQ
D
H
Y
A
A
A
FG---G---F---N
F
M
ESRPNG
E
V
V
V----------------------
N
P
L
R
I
R
R
E
V
I
A
E
L
E
------
A
S
L
L
L
Y
FG--
G
V
S
R
L
S
S
------------
E
-----
V
--------
I
-----------------------------------
A
D
------
Q
Q
R
N
V
-----
V
-------------
E
R
------
D
-------------------------------------------
A
----------------
D
A
----
L
-------------
A
A
T
H
---
S
I
C
------
A
E
--
A
L
EMK
D
L
L
V
VG-------DIP
G
F
A
D
S
L
L
R
G
W
Q
AKKRTSTRISN-----
P
A
I
E
H
A
Y
Q
V
A
Q
S-S-G
M
V
A
G
K
V
SGAGGG
G
F
L
M
M
I
VD
P
R
R
---
R
I
E
V
A
R
S
L
E
R
E---C-G--GSVA
P
C
L
FTKG
G
A
V
T
W
HIPEST
A
P
V
R
R
G
V
A
D
A
V
A
S
A
LGNAG
I
L
L
C
A
G
C
V
LATSHSTWRVPV
21
PsiBlast_CBE
95.21
47%
-93
- C3 -
4UTG
5
?
B:
[5-344]
-------------------
I
I
R
A
R
A
P
L
R
L
G
L
A
G
G
G
T
D
V
A
P
Y
A
D
T
F
G
G
Y
V
L
N
A
T
I
D
R
Y
A
Y
A
V
I
K
T
L
T
I
P
--
A
V
R
F
V
S
T
D
Q
Q
V
----
E
--
K
H
Q
L
I
---
S
-
E
----
P
--
L
-
E
-
L
-
N
G
----
T
L
N
L
H
K
---------------
A
V
Y
N
H
M
I
R
N
Y
--------
N
--
H
-
G
K
P
I
A
L
E
L
S
T
F
C
D
A
P
A
G
S
G
L
G
S
S
S
T
L
V
V
V
M
I
K
A
F
V
E
L
L
--
N
L
P
L
D
D
Y
A
---------------
I
A
Q
L
A
Y
R
I
E
R
V
D
C
G
L
A
G
G
R
Q
D
Q
Y
S
A
T
F
G
---
G
---
F
---
N
F
M
E
F
Y
A
A
A
R
T
I
V
----------------------
N
P
L
R
I
K
N
W
V
L
C
E
L
E
------
A
S
L
V
L
F
Y
T
--
G
V
S
R
E
S
A
------------
K
-----
I
--------
I
-----------------------------------
Q
D
------
Q
S
D
N
V
-----
V
-------------
S
H
------
K
-------------------------------------------
T
----------------
A
A
----
I
-------------
E
A
M
H
---
G
I
K
------
R
E
--
A
L
V
M
K
E
A
L
L
K
G
-------
D
F
K
A
F
V
A
S
M
R
L
G
W
D
N
K
K
N
S
A
R
T
V
S
N
-----
A
H
I
D
E
I
Y
D
A
A
I
R
-
A
-
G
A
Q
A
G
K
V
S
G
A
G
G
G
G
F
M
L
F
F
V
P
T
E
K
---
R
M
D
L
I
R
T
L
G
-
E
---
Y
-
D
--
G
Q
V
S
N
C
H
F
T
K
N
G
T
Q
A
W
R
I
-------------------------------------------
2
PsiBlast_PDB
95.10
47%
-95
- C3 -
4UT4
5
?
A:
[5-344]
-------------------
I
I
R
A
R
A
P
L
R
L
G
L
A
G
G
G
T
D
V
A
P
Y
A
D
T
F
G
G
Y
V
L
N
A
T
I
D
R
Y
A
Y
A
V
I
K
T
L
T
I
P
--
A
V
R
F
V
S
T
D
Q
Q
V
----
E
--
K
H
Q
L
I
---
S
-
E
----
P
--
L
-
E
-
L
-
N
G
----
T
L
N
L
H
K
---------------
A
V
Y
N
H
M
I
R
N
Y
--------
N
--
H
-
G
K
P
I
A
L
E
L
S
T
F
C
D
A
P
A
G
S
G
L
G
S
S
S
T
L
V
V
V
M
I
K
A
F
V
E
L
L
--
N
L
P
L
D
D
Y
A
---------------
I
A
Q
L
A
Y
R
I
E
R
V
D
C
G
L
A
G
G
R
Q
D
Q
Y
S
A
T
F
G
---
G
---
F
---
N
F
M
E
F
Y
A
A
A
R
T
I
V
----------------------
N
P
L
R
I
K
N
W
V
L
C
E
L
E
------
A
S
L
V
L
F
Y
T
--
G
V
S
R
E
S
A
------------
K
-----
I
--------
I
-----------------------------------
Q
D
------
Q
S
D
N
V
-----
V
-------------
S
H
------
K
-------------------------------------------
T
----------------
A
A
----
I
-------------
E
A
M
H
---
G
I
K
------
R
E
--
A
L
V
M
K
E
A
L
L
K
G
-------
D
F
K
A
F
V
A
S
M
R
L
G
W
D
N
K
K
N
S
A
R
T
V
S
N
-----
A
H
I
D
E
I
Y
D
A
A
I
R
-
A
-
G
A
Q
A
G
K
V
S
G
A
G
G
G
G
F
M
L
F
F
V
P
T
E
K
---
R
M
D
L
I
R
T
L
G
-
E
---
Y
-
D
--
G
Q
V
S
N
C
H
F
T
K
N
G
T
Q
A
W
R
I
-------------------------------------------
22
PsiBlast_CBE
95.03
47%
-95
- C3 -
4UT4
5
?
B:
[5-344]
-------------------
I
I
R
A
R
A
P
L
R
L
G
L
A
G
G
G
T
D
V
A
P
Y
A
D
T
F
G
G
Y
V
L
N
A
T
I
D
R
Y
A
Y
A
V
I
K
T
L
T
I
P
--
A
V
R
F
V
S
T
D
Q
Q
V
----
E
--
K
H
Q
L
I
---
S
-
E
----
P
--
L
-
E
-
L
-
N
G
----
T
L
N
L
H
K
---------------
A
V
Y
N
H
M
I
R
N
Y
--------
N
--
H
-
G
K
P
I
A
L
E
L
S
T
F
C
D
A
P
A
G
S
G
L
G
S
S
S
T
L
V
V
V
M
I
K
A
F
V
E
L
L
--
N
L
P
L
D
D
Y
A
---------------
I
A
Q
L
A
Y
R
I
E
R
V
D
C
G
L
A
G
G
R
Q
D
Q
Y
S
A
T
F
G
---
G
---
F
---
N
F
M
E
F
Y
A
A
A
R
T
I
V
----------------------
N
P
L
R
I
K
N
W
V
L
C
E
L
E
------
A
S
L
V
L
F
Y
T
--
G
V
S
R
E
S
A
------------
K
-----
I
--------
I
-----------------------------------
Q
D
------
Q
S
D
N
V
-----
V
-------------
S
H
------
K
-------------------------------------------
T
----------------
A
A
----
I
-------------
E
A
M
H
---
G
I
K
------
R
E
--
A
L
V
M
K
E
A
L
L
K
G
-------
D
F
K
A
F
V
A
S
M
R
L
G
W
D
N
K
K
N
S
A
R
T
V
S
N
-----
A
H
I
D
E
I
Y
D
A
A
I
R
-
A
-
G
A
Q
A
G
K
V
S
G
A
G
G
G
G
F
M
L
F
F
V
P
T
E
K
---
R
M
D
L
I
R
T
L
G
-
E
---
Y
-
D
--
G
Q
V
S
N
C
H
F
T
K
N
G
T
Q
A
W
R
I
-------------------------------------------
3
PsiBlast_PDB
94.26
47%
-93
- C3 -
4UTG
5
?
A:
[5-344]
-------------------
I
I
R
A
R
A
P
L
R
L
G
L
A
G
G
G
T
D
V
A
P
Y
A
D
T
F
G
G
Y
V
L
N
A
T
I
D
R
Y
A
Y
A
V
I
K
T
L
T
I
P
--
A
V
R
F
V
S
T
D
Q
Q
V
----
E
--
K
H
Q
L
I
---
S
-
E
----
P
--
L
-
E
-
L
-
N
G
----
T
L
N
L
H
K
---------------
A
V
Y
N
H
M
I
R
N
Y
--------
N
--
H
-
G
K
P
I
A
L
E
L
S
T
F
C
D
A
P
A
G
S
G
L
G
S
S
S
T
L
V
V
V
M
I
K
A
F
V
E
L
L
--
N
L
P
L
D
D
Y
A
---------------
I
A
Q
L
A
Y
R
I
E
R
V
D
C
G
L
A
G
G
R
Q
D
Q
Y
S
A
T
F
G
---
G
---
F
---
N
F
M
E
F
Y
A
A
A
R
T
I
V
----------------------
N
P
L
R
I
K
N
W
V
L
C
E
L
E
------
A
S
L
V
L
F
Y
T
--
G
V
S
R
E
S
A
------------
K
-----
I
--------
I
-----------------------------------
Q
D
------
Q
S
D
N
V
-----
V
-------------
S
H
------
K
-------------------------------------------
T
----------------
A
A
----
I
-------------
E
A
M
H
---
G
I
K
------
R
E
--
A
L
V
M
K
E
A
L
L
K
G
-------
D
F
K
A
F
V
A
S
M
R
L
G
W
D
N
K
K
N
S
A
R
T
V
S
N
-----
A
H
I
D
E
I
Y
D
A
A
I
R
-
A
-
G
A
Q
A
G
K
V
S
G
A
G
G
G
G
F
M
L
F
F
V
P
T
E
K
---
R
M
D
L
I
R
T
L
G
-
E
---
Y
-
D
--
G
Q
V
S
N
C
H
F
T
K
N
G
T
Q
A
W
R
I
-------------------------------------------
24
PsiBlast_CBE
93.96
47%
-93
- C3 -
4USM
5
?
B:
[5-344]
-------------------
I
I
R
A
R
A
P
L
R
L
G
L
A
G
G
G
T
D
V
A
P
Y
A
D
T
F
G
G
Y
V
L
N
A
T
I
D
R
Y
A
Y
A
V
I
K
T
L
T
I
P
--
A
V
R
F
V
S
T
D
Q
Q
V
----
E
--
K
H
Q
L
I
---
S
-
E
----
P
--
L
-
E
-
L
-
N
G
----
T
L
N
L
H
K
---------------
A
V
Y
N
H
M
I
R
N
Y
--------
N
--
H
-
G
K
P
I
A
L
E
L
S
T
F
C
D
A
P
A
G
S
G
L
G
S
S
S
T
L
V
V
V
M
I
K
A
F
V
E
L
L
--
N
L
P
L
D
D
Y
A
---------------
I
A
Q
L
A
Y
R
I
E
R
V
D
C
G
L
A
G
G
R
Q
D
Q
Y
S
A
T
F
G
---
G
---
F
---
N
F
M
E
F
Y
E
E
E
R
T
I
V
----------------------
N
P
L
R
I
K
N
W
V
L
C
E
L
E
------
A
S
L
V
L
F
Y
T
--
G
V
S
R
E
S
A
------------
K
-----
I
--------
I
-----------------------------------
Q
D
------
Q
S
D
N
V
-----
V
-------------
S
H
------
K
-------------------------------------------
T
----------------
A
A
----
I
-------------
E
A
M
H
---
G
I
K
------
R
E
--
A
L
V
M
K
E
A
L
L
K
G
-------
D
F
K
A
F
V
A
S
M
R
L
G
W
D
N
K
K
N
S
A
R
T
V
S
N
-----
A
H
I
D
E
I
Y
D
A
A
I
R
-
A
-
G
A
Q
A
G
K
V
S
G
A
G
G
G
G
F
M
L
F
F
V
P
T
E
K
---
R
M
D
L
I
R
T
L
G
-
E
---
Y
-
D
--
G
Q
V
S
N
C
H
F
T
K
N
G
T
Q
A
W
R
I
-------------------------------------------
4
PsiBlast_PDB
93.73
47%
-92
- C3 -
4USM
5
?
A:
[5-344]
-------------------
I
I
R
A
R
A
P
L
R
L
G
L
A
G
G
G
T
D
V
A
P
Y
A
D
T
F
G
G
Y
V
L
N
A
T
I
D
R
Y
A
Y
A
V
I
K
T
L
T
I
P
--
A
V
R
F
V
S
T
D
Q
Q
V
----
E
--
K
H
Q
L
I
---
S
-
E
----
P
--
L
-
E
-
L
-
N
G
----
T
L
N
L
H
K
---------------
A
V
Y
N
H
M
I
R
N
Y
--------
N
--
H
-
G
K
P
I
A
L
E
L
S
T
F
C
D
A
P
A
G
S
G
L
G
S
S
S
T
L
V
V
V
M
I
K
A
F
V
E
L
L
--
N
L
P
L
D
D
Y
A
---------------
I
A
Q
L
A
Y
R
I
E
R
V
D
C
G
L
A
G
G
R
Q
D
Q
Y
S
A
T
F
G
---
G
---
F
---
N
F
M
E
F
Y
E
E
E
R
T
I
V
----------------------
N
P
L
R
I
K
N
W
V
L
C
E
L
E
------
A
S
L
V
L
F
Y
T
--
G
V
S
R
E
S
A
------------
K
-----
I
--------
I
-----------------------------------
Q
D
------
Q
S
D
N
V
-----
V
-------------
S
H
------
K
-------------------------------------------
T
----------------
A
A
----
I
-------------
E
A
M
H
---
G
I
K
------
R
E
--
A
L
V
M
K
E
A
L
L
K
G
-------
D
F
K
A
F
V
A
S
M
R
L
G
W
D
N
K
K
N
S
A
R
T
V
S
N
-----
A
H
I
D
E
I
Y
D
A
A
I
R
-
A
-
G
A
Q
A
G
K
V
S
G
A
G
G
G
G
F
M
L
F
F
V
P
T
E
K
---
R
M
D
L
I
R
T
L
G
-
E
---
Y
-
D
--
G
Q
V
S
N
C
H
F
T
K
N
G
T
Q
A
W
R
I
-------------------------------------------
1
PsiBlast_PDB
93.68
47%
-91
- C3 -
4USK
6
?
A:
[5-344]
-------------------
I
I
R
A
R
A
P
L
R
L
G
L
A
G
G
G
T
D
V
A
P
Y
A
D
T
F
G
G
Y
V
L
N
A
T
I
D
R
Y
A
Y
A
V
I
K
T
L
T
I
P
--
A
V
R
F
V
S
T
D
Q
Q
V
----
E
--
K
H
Q
L
I
---
S
-
E
----
P
--
L
-
E
-
L
-
N
G
----
T
L
N
L
H
K
---------------
A
V
Y
N
H
M
I
R
N
Y
--------
N
--
H
-
G
K
P
I
A
L
E
L
S
T
F
C
D
A
P
A
G
S
G
L
G
S
S
S
T
L
V
V
V
M
I
K
A
F
V
E
L
L
--
N
L
P
L
D
D
Y
A
---------------
I
A
Q
L
A
Y
R
I
E
R
V
D
C
G
L
A
G
G
R
Q
D
Q
Y
S
A
T
F
G
---
G
---
F
---
N
F
M
E
F
Y
A
A
A
R
T
I
V
----------------------
N
P
L
R
I
K
N
W
V
L
C
E
L
E
------
A
S
L
V
L
F
Y
T
--
G
V
S
R
E
S
A
------------
K
-----
I
--------
I
-----------------------------------
Q
D
------
Q
S
D
N
V
-----
V
-------------
S
H
------
K
-------------------------------------------
T
----------------
A
A
----
I
-------------
E
A
M
H
---
G
I
K
------
R
E
--
A
L
V
M
K
E
A
L
L
K
G
-------
D
F
K
A
F
V
A
S
M
R
L
G
W
D
N
K
K
N
S
A
R
T
V
S
N
-----
A
H
I
D
E
I
Y
D
A
A
I
R
-
A
-
G
A
Q
A
G
K
V
S
G
A
G
G
G
G
F
M
L
F
F
V
P
T
E
K
---
R
M
D
L
I
R
T
L
G
-
E
---
Y
-
D
--
G
Q
V
S
N
C
H
F
T
K
N
G
T
Q
A
W
R
I
-------------------------------------------
23
PsiBlast_CBE
93.13
47%
-92
- C3 -
4USK
7
?
B:
[5-344]
-------------------
I
I
R
A
R
A
P
L
R
L
G
L
A
G
G
G
T
D
V
A
P
Y
A
D
T
F
G
G
Y
V
L
N
A
T
I
D
R
Y
A
Y
A
V
I
K
T
L
T
I
P
--
A
V
R
F
V
S
T
D
Q
Q
V
----
E
--
K
H
Q
L
I
---
S
-
E
----
P
--
L
-
E
-
L
-
N
G
----
T
L
N
L
H
K
---------------
A
V
Y
N
H
M
I
R
N
Y
--------
N
--
H
-
G
K
P
I
A
L
E
L
S
T
F
C
D
A
P
A
G
S
G
L
G
S
S
S
T
L
V
V
V
M
I
K
A
F
V
E
L
L
--
N
L
P
L
D
D
Y
A
---------------
I
A
Q
L
A
Y
R
I
E
R
V
D
C
G
L
A
G
G
R
Q
D
Q
Y
S
A
T
F
G
---
G
---
F
---
N
F
M
E
F
Y
A
A
A
R
T
I
V
----------------------
N
P
L
R
I
K
N
W
V
L
C
E
L
E
------
A
S
L
V
L
F
Y
T
--
G
V
S
R
E
S
A
------------
K
-----
I
--------
I
-----------------------------------
Q
D
------
Q
S
D
N
V
-----
V
-------------
S
H
------
K
-------------------------------------------
T
----------------
A
A
----
I
-------------
E
A
M
H
---
G
I
K
------
R
E
--
A
L
V
M
K
E
A
L
L
K
G
-------
D
F
K
A
F
V
A
S
M
R
L
G
W
D
N
K
K
N
S
A
R
T
V
S
N
-----
A
H
I
D
E
I
Y
D
A
A
I
R
-
A
-
G
A
Q
A
G
K
V
S
G
A
G
G
G
G
F
M
L
F
F
V
P
T
E
K
---
R
M
D
L
I
R
T
L
G
-
E
---
Y
-
D
--
G
Q
V
S
N
C
H
F
T
K
N
G
T
Q
A
W
R
I
-------------------------------------------
27
HHSearch
91.89
46%
-91
- C3 -
4USK
6
?
A:
[4-345]
------------------
T
I
I
R
A
R
A
P
L
R
L
G
L
A
G
G
G
T
D
V
A
P
Y
A
D
T
F
G
G
Y
V
L
N
A
T
I
D
R
Y
A
Y
A
V
I
K
T
L
T
I
P
--
A
V
R
F
V
S
T
D
Q
Q
V
-------
E
K
H
Q
L
---
I
-
S
----
E
--
P
-
L
-
E
L
N
G
----
T
L
N
L
H
K
---------------
A
V
Y
N
H
M
I
R
N
Y
--------
N
--
H
G
K
P
-
I
A
L
E
L
S
T
F
C
D
A
P
A
G
S
G
L
G
S
S
S
T
L
V
V
V
M
I
K
A
F
V
E
L
L
--
N
L
P
L
D
D
Y
A
---------------
I
A
Q
L
A
Y
R
I
E
R
V
D
C
G
L
A
G
G
R
Q
D
Q
Y
S
A
T
F
G
---
G
---
F
---
N
F
M
E
F
Y
A
A
A
R
T
I
V
----------------------
N
P
L
R
I
K
N
W
V
L
C
E
L
E
------
A
S
L
V
L
F
Y
T
--
G
V
S
R
E
S
A
------------
K
-----
I
--------
I
-----------------------------------
Q
D
------
Q
S
D
N
V
-----
V
-------------
S
H
------
K
-------------------------------------------
T
----------------
A
A
----
I
-------------
E
A
M
H
---
G
I
K
------
R
E
--
A
L
V
M
K
E
A
L
L
K
G
-------
D
F
K
A
F
V
A
S
M
R
L
G
W
D
N
K
K
N
S
A
R
T
V
S
N
-----
A
H
I
D
E
I
Y
D
A
A
I
R
-
A
-
G
A
Q
A
G
K
V
S
G
A
G
G
G
G
F
M
L
F
F
V
P
T
E
K
---
R
M
D
L
I
R
T
L
G
E
----
Y
-
D
--
G
Q
V
S
N
C
H
F
T
K
N
G
T
Q
A
W
R
I
A
------------------------------------------
26
HHSearch
83.25
38%
-103
- C3 -
4N3O
-
?
A:
[4-341]
-----------------
M
K
T
I
R
T
Q
T
P
L
R
L
G
L
A
G
G
G
T
D
I
N
L
Y
C
D
K
Y
T
G
Y
V
L
N
A
T
I
S
L
Y
I
H
C
T
L
I
K
R
E
D
G
--
K
I
I
F
D
S
P
D
T
N
S
----
Y
--
C
E
Y
E
S
----------
K
--
E
-
F
L
G
N
D
G
----
K
L
D
I
F
K
---------------
S
I
Y
N
R
I
V
K
D
F
--------
T
--
K
-
K
P
-
L
S
F
S
L
H
T
Y
S
D
V
P
S
G
S
G
L
G
G
S
S
T
L
V
V
G
V
I
K
A
F
A
E
W
L
--
N
L
P
L
G
E
Y
E
---------------
I
A
K
L
A
Y
E
I
E
R
E
D
L
G
I
V
G
G
A
Q
D
Q
Y
A
A
T
F
G
---
G
---
F
---
N
F
M
E
F
Y
N
N
K
R
V
I
V
----------------------
N
P
L
R
I
K
N
W
I
A
S
E
L
E
------
A
R
T
V
L
Y
F
T
--
N
I
T
R
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----
L
-------------
E
A
M
H
---
A
I
K
------
Q
D
--
A
I
K
M
K
E
A
L
F
R
A
-------
D
F
G
T
L
A
Q
I
L
G
K
S
W
R
S
K
K
I
I
S
E
I
V
S
N
-----
D
E
L
E
R
I
Y
K
L
A
I
D
-
N
-
G
A
Y
S
G
K
T
S
G
A
G
A
G
G
F
M
F
F
F
V
D
P
T
K
---
K
Y
N
L
I
K
A
L
R
K
----
E
-
Q
--
G
Y
V
Q
D
F
S
F
T
K
E
G
V
K
S
W
R
--------------------------------------------
6
PsiBlast_PDB
81.77
37%
-98
- C3 -
4N3O
-
?
A:
[7-342]
--------------------
I
R
T
Q
T
P
L
R
L
G
L
A
G
G
G
T
D
I
N
L
Y
C
D
K
Y
T
G
Y
V
L
N
A
T
I
S
L
Y
I
H
C
T
L
I
K
R
E
D
G
--
K
I
I
F
D
S
P
D
T
N
S
----
Y
--
C
E
Y
E
S
---
K
-
E
----
F
--
L
-
G
-
N
-
D
G
----
K
L
D
I
F
K
---------------
S
I
Y
N
R
I
V
K
D
F
--------
T
--
K
--
K
P
L
S
F
S
L
H
T
Y
S
D
V
P
S
G
S
G
L
G
G
S
S
T
L
V
V
G
V
I
K
A
F
A
E
W
L
--
N
L
P
L
G
E
Y
E
---------------
I
A
K
L
A
Y
E
I
E
R
E
D
L
G
I
V
G
G
A
Q
D
Q
Y
A
A
T
F
G
---
G
---
F
---
N
F
M
E
F
Y
N
N
K
R
V
I
V
----------------------
N
P
L
R
I
K
N
W
I
A
S
E
L
E
------
A
R
T
V
L
Y
F
T
--
N
I
T
R
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----
L
-------------
E
A
M
H
---
A
I
K
------
Q
D
--
A
I
K
M
K
E
A
L
F
R
A
-------
D
F
G
T
L
A
Q
I
L
G
K
S
W
R
S
K
K
I
I
S
E
I
V
S
N
-----
D
E
L
E
R
I
Y
K
L
A
I
D
-
N
-
G
A
Y
S
G
K
T
S
G
A
G
A
G
G
F
M
F
F
F
V
D
P
T
K
---
K
Y
N
L
I
K
A
L
R
K
E
-----
Q
--
G
Y
V
Q
D
F
S
F
T
K
E
G
V
K
S
W
R
I
-------------------------------------------
34
HHSearch
66.00
20%
-87
- C3 -
2CZ9
3
GAL1_PYRHO
A:
[1-327]
-------------------
M
I
K
V
K
S
P
G
R
V
N
L
I
G
E
H
T
D
Y
------
T
Y
G
Y
V
M
P
M
A
I
N
L
Y
T
K
I
E
A
E
K
H
G
----
E
V
I
L
Y
S
E
H
F
G
E
----
E
--
R
K
F
S
L
---
N
-
D
----
L
----
R
-
K
E
N
S
----
W
I
D
Y
V
K
---------------
G
I
F
W
V
L
K
E
S
---------
D
--
Y
-
E
V
-
G
G
I
K
G
R
V
S
G
N
L
P
L
G
A
G
L
S
S
S
A
S
F
E
V
G
I
L
E
T
L
D
K
L
Y
--
N
L
K
L
D
S
L
S
---------------
K
V
L
L
A
K
K
A
E
N
E
F
V
G
V
P
C
G
I
L
D
Q
F
A
V
V
F
G
REG
N
---
V
---
I
F
L
D
T
H
T
---
L
D
Y
----------------------
E
Y
I
P
F
P
K
------
D
------
V
S
I
L
V
F
Y
T
--
G
V
R
----------------
S
S
E
---
Y
--------
A
-----------------------------------
E
R
K
H
I
A
E
E
S
L
K
I
L
-----
G
KGSSKEVREGELS
K
L
------
P
-------------------------------------------
P
----------------
L
H
----
R
-------------
K
F
F
G
Y
I
V
R
E
N
------
A
R
--
V
L
E
V
R
D
A
L
K
E
G
-------
N
V
E
E
V
G
K
I
L
T
T
A
H
W
D
L
A
K
N
Y
-
E
V
S
C
-----
K
E
L
D
F
F
V
E
R
A
L
K
-
L
-
G
A
Y
G
A
R
L
T
G
A
G
F
G
G
S
A
I
A
L
V
D
K
E
D
---
A
E
T
I
G
E
E
I
L
R
----------------------------------------------------------------------
52
Fugue
62.35
20%
-77
- C3 -
1KVK
2
KIME_RAT
A:
[1-394]
---------------ML
S
E
V
L
L
V
S
A
P
G
K
V
I
L
H
G
E
------
H
A
V
V
H
G
K
V
A
L
A
V
A
L
N
L
R
T
F
L
V
L
R
P
Q
S
N
G
--
K
V
S
L
N
L
P
N
V
G
I
----
K
--
Q
V
W
D
V
---
A
-
T
----
L
--
Q
-
L
-
L
-
D
T
----
E
K
L
K
K
V
A
G
L
P
R
D
C
V
G
NE
G
L
S
L
L
A
F
L
Y
L
Y
L
A
I
CR------
K
--
Q
-
R
T
L
P
S
L
D
I
M
V
W
S
E
L
P
P
G
A
G
L
G
S
S
A
A
Y
S
V
C
V
A
A
A
L
L
T
A
C
--
E
E
V
T
N
P
L
K
DRGS
I
G
S
W
P
E
E
D
L
K
S
I
N
K
W
A
Y
E
G
E
R
V
I
H
G
N
P
S
G
-
V
D
N
S
V
S
T
W
G
---
G
---
A
---
L
R
Y
Q
Q
G
K
---------------------------------
M
S
S
L
K
R
L
P
A
------
L
Q
I
L
L
T
N
T
--
K
V
P
R
S
T
K
------------
A
-----
L
--------
V
-----------------------------------
A
G
------
V
R
S
R
L
-----
I
-------------
K
F
------
P
-------------------------------------------
E
----------------
I
M
----
A
-------------
P
L
L
T
---
S
I
D
------
A
I
--
S
L
E
C
E
R
V
L
G
E
M
-------
A
A
A
P
V
P
E
Q
Y
L
V
L
E
E
L
M
D
M
N
Q
H
H
L
N
A
L
GVGH
A
S
L
D
Q
L
C
Q
V
T
A
A
-
H
-
G
L
-
H
S
K
L
T
G
A
G
G
G
G
C
G
I
T
L
L
K
P
G
L
---
E
R
A
K
V
E
A
A
K
Q
A
---
L
-
T
--
G
C
G
F
D
C
W
E
T
S
I
G
A
P
G
V
S
M
H
S
A
-----
T
S
I
E
D
P
V
R
Q
A
L
G
-----------------------
32
HHSearch
62.21
23%
-90
* C3 *
4HAC
1
?
A:
[20-320]
------------------
H
M
V
S
C
S
A
P
G
K
I
Y
L
F
G
E
H
A
V
V
------
Y
G
E
T
A
I
A
C
A
V
E
L
R
T
R
V
R
A
E
L
N
D
S
I
----
T
I
Q
S
Q
-
I
G
R
---------
T
-----------------
G
-
L
D
F
E
----
K
H
P
Y
V
S
---------------
A
V
I
E
K
M
R
K
S
I
-----------
P
--
I
-
N
G
V
F
L
T
V
D
S
D
I
P
V
G
S
G
L
G
S
S
A
A
V
T
I
A
S
I
G
A
L
N
E
L
F
--
G
F
G
L
S
L
Q
E
---------------
I
A
K
L
G
H
E
I
E
I
K
V
Q
G
A
A
S
-
P
T
D
T
Y
V
S
T
F
G
---
G
---
V
---
V
T
I
P
E
R
R
-----------------------------
K
L
K
T
-------
P
D
------
C
G
I
V
I
G
D
T
--
G
V
F
S
S
T
K
------------
E
-----
L
--------
V
-----------------------------------
A
N
------
V
R
Q
L
R
-----
E
-------------
S
Y
------
P
-------------------------------------------
D
----------------
L
I
----
E
-------------
P
L
M
T
---
S
I
G
------
K
I
--
S
R
I
G
E
Q
L
V
L
S
G
-------
D
Y
A
S
I
G
R
L
M
N
V
N
Q
G
L
L
D
A
L
--
G
V
N
I
-----
L
E
L
S
Q
L
I
Y
S
A
R
A
-
A
-
G
A
F
G
A
K
I
T
G
A
G
G
G
G
C
M
V
A
L
T
A
P
E
K
---
C
N
Q
V
A
E
A
V
A
G
----
A
-
G
--
G
K
V
T
I
T
K
P
T
E
Q
G
L
K
V
----------------------------------------------
30
HHSearch
61.47
17%
-75
- C3 -
1PIE
2
GAL1_LACLA
A:
[49-416]
--------------------
E
Y
F
F
S
P
G
R
I
N
L
I
G
E
H
T
D
Y
------
N
G
G
Y
V
F
P
A
S
I
T
I
G
T
T
G
L
A
R
L
R
E
D
K
--
K
V
K
L
Y
S
E
N
F
P
K
----
L
G
V
I
E
F
D
L
---
D
-
E
----
V
--
E
K
K
-
D
G
E
L
----
W
S
N
Y
V
K
---------------
G
M
I
V
M
L
K
G
A
G
--------
Y
--
E
-
I
D
-
K
G
F
E
L
L
I
K
G
E
I
P
T
A
S
G
L
S
S
S
A
S
L
E
L
L
V
G
V
V
L
D
D
L
F
--
N
L
N
V
P
R
L
E
---------------
L
V
Q
L
G
Q
K
T
E
N
D
Y
I
G
V
N
S
G
I
L
D
Q
F
A
I
G
F
G
---
E
---
V
---
K
K
A
I
E
L
D
C
N
T
L
K
Y
----------------------
E
M
V
P
V
E
L
-----
R
D
------
Y
D
I
V
I
M
N
T
--
N
K
P
R
A
L
T
E
S
K
Y
N
E
R
F
A
E
T
R
E
-----
A
--------
L
-----------------------------------
K
R
------
M
Q
T
R
L
DIQSL
G
-------------
E
L
S-----
N
-------------------------------------------
E
----------------
E
F
----
D
A
N
TDLIGD
E
T
L
I
K
R
A
R
H
---
A
V
Y
E
N
----
N
R
--
T
K
I
A
Q
K
A
F
V
A
G
-------
N
L
T
K
F
G
E
L
L
N
A
S
H
A
S
L
K
D
D
Y
-
E
V
T
G
-----
L
E
L
D
T
L
A
E
T
A
Q
K
Q
A
-
G
V
L
G
A
R
M
T
G
A
G
F
G
G
C
A
I
A
L
V
A
H
D
N
---
V
S
A
F
R
K
A
V
G
Q
V
Y
E
E
V
V
G
Y
P
A
S
F
Y
V
A
Q
I
G
-
S
G
S
T
K
L
---------------------------------------------
51
Fugue
60.54
16%
-70
- C3 -
1PIE
2
GAL1_LACLA
A:
[29-416]
T
V
L
S
A
L
T
E
K
F
A
E
V
F
GDT
K
E
V
E
Y
F
F
S
P
G
R
I
N
L
I
G
E
H
T
D
Y
N
------
G
G
Y
V
F
P
A
S
I
T
I
G
T
T
G
L
A
R
L
R
E
D
K
--
K
V
K
L
Y
S
E
N
F
P
K
----
L
--
G
V
I
E
F
D
LD
E
-
V
----
E
--
K
-
K
-
D
-
G
E
----
L
W
S
N
Y
V
---------------
K
G
M
I
V
M
L
K
G
A
--------
G
--
Y
-
E
I
D
K
G
F
E
L
L
I
K
G
E
I
P
T
A
S
G
L
S
S
S
A
S
L
E
L
L
V
G
V
V
L
D
D
L
F
--
N
L
N
V
P
R
L
E
---------------
L
V
Q
L
G
Q
K
T
E
N
D
Y
I
G
V
N
S
G
I
L
D
Q
F
A
I
G
F
G
---
E
VKK
A
---
I
E
L
D
C
N
T
L
K
Y
E
M
V
P
VELRDYDI
V
I
M
N
TNKPRALTE
S
K
Y
N
E
R
F
A
E
T
R
E
A
L
------
K
R
M
Q
T
R
L
D
IQ
S
L
G
E
L
S
N
------------
E
-----
E
--------
F
-----------------------------------
D
A
------
N
T
D
L
I
G----
D
-------------
E
T
------
L
-------------------------------------------
I
----------------
K
R
----
A
-------------
R
H
A
V
---
Y
E
N
------
N
R
--
T
K
I
A
Q
K
A
F
V
A
G
-------
N
L
T
K
F
G
E
L
L
N
A
S
H
A
S
L
K
D
D
Y
-
E
V
T
G
-----
L
E
L
D
T
L
A
E
T
A
Q
K
Q
A
-
G
V
L
G
A
R
M
T
G
A
G
F
G
G
C
A
I
A
L
V
A
H
D
N
---
V
S
A
F
R
K
A
V
G
Q
V
---
Y
-
E
--
E
V
V
-------
G
Y
P
A
S
F
Y
V
A
Q
I
G
S
G
S
T
K
L
---------------------------------
37
HHSearch
58.23
17%
-72
- C3 -
1WUU
3
GALK1_HUMAN
A:
[36-397]
-------------------
E
L
A
V
S
A
P
G
R
V
N
L
I
G
E
H
T
D
Y
------
N
Q
G
L
V
L
P
M
A
L
E
L
M
T
V
L
V
G
S
P
R
K
D
G
--
L
V
S
L
L
T
T
S
E
G
A
DEPQ
R
--
L
Q
F
P
L
---
P
-
T
AQ
R
S
L
--
E
-
P
-
G
T
P
R
----
W
A
N
Y
V
K
---------------
G
V
I
Q
Y
Y
P
A
A
------------
P
--
L
-
P
G
F
S
A
V
V
V
S
S
V
P
L
G
G
G
L
S
S
S
A
S
L
E
V
A
T
Y
T
F
L
Q
Q
L
C
--
P
D
S
G
T
I
A
A
---------------
R
A
Q
V
C
Q
Q
A
E
H
S
F
A
G
M
P
C
G
I
M
D
Q
F
I
S
L
M
G
---
Q
---
K
GHA
L
L
I
D
C
R
S
L
---
E
T
----------------------
S
L
V
P
L
S
D
-----
P
K
------
L
A
V
L
I
T
N
S
--
N
V
R
H
--
A
------------
S
-----
S
E
Y
P
V
R
R
R
Q
C
-----------------------------------
E
E
------
V
A
R
A
L
-----
G
-------------
K
E
SL----
R
-------------------------------------------
E
VQ
L
E
E
L
E
A
A
RDLVS
K
E
G
F
----
R
-------------
R
A
R
H
---
V
V
G
------
E
I
R
R
T
A
Q
A
A
A
A
L
R
R
G
-------
D
Y
R
A
F
G
R
L
M
V
E
S
H
R
S
L
R
D
D
Y
-
E
V
S
C
-----
P
E
L
D
Q
L
V
E
A
A
L
A
-
V
P
G
V
Y
G
S
R
M
T
G
G
G
F
G
G
C
T
V
T
L
L
E
A
S
A
---
A
P
H
A
M
R
H
I
Q
E
H
---
Y
-
G
G
T
A
T
F
Y
L
S
Q
-
A
A
D
G
A
K
V
L
---------------------------------------------
7
PsiBlast_PDB
58.10
19%
-91
- C3 -
1KKH
2
MVK_METJA
A:
[24-291]
--------------------------------------------
Y
G
Y
R
A
I
S
M
A
I
D
L
T
S
T
I
E
I
K
E
T
Q
E
D
--
E
I
I
L
N
L
N
D
L
N
K
----
S
--
L
G
L
N
L
---
N
-
E
----
I
--
K
-
N
-
I
-
N
P
NNFG
D
F
K
Y
C
L
---------------
C
A
I
K
N
T
L
D
Y
L
--------
N
IE
P
-
K
T
G
F
K
I
N
I
S
S
K
I
--
P
I
S
C
G
L
G
S
S
A
S
I
T
I
G
T
I
K
A
V
S
G
F
Y
--
N
K
E
L
K
D
D
E
---------------
I
A
K
L
G
Y
M
V
E
K
E
I
Q
G
K
A
S
-
I
T
D
T
S
T
I
T
Y
K
---
G
---
I
-----
L
E
I
K
N
N
K
-------------------------------
F
R
K
I
K
G
E
F
E
E
F
L
K
N
C
K
F
L
I
V
Y
A
E
--
K
R
K
K
K
T
A
------------
E
-----
L
--------
V
-----------------------------------
N
E
------
V
A
K
-------
I
-------------
E
N
------
K
-------------------------------------------
D
----------------
E
I
----
F
-------------
K
E
I
D
---
K
V
I
------
D
E
--
A
L
K
I
K
N
K
E
D
F
G
-------
K
L
M
T
K
N
H
E
L
L
K
K
L
N
--------
I
S
T
-----
P
K
L
D
R
I
V
D
I
G
N
R
-
F
-
G
F
G
A
-
K
L
T
G
A
G
G
G
G
C
V
I
I
L
V
---------------------------------------------------------------------------------------
8
PsiBlast_PDB
57.27
19%
-89
- C3 -
1VIS
1
MVK_METJA
A:
[21-288]
--------------------------------------------
Y
G
Y
R
A
I
S
M
A
I
D
L
T
S
T
I
E
I
K
E
T
Q
E
D
--
E
I
I
L
N
L
N
D
L
N
K
----
S
--
L
G
L
N
L
---
N
-
E
----
I
--
K
-
N
-
I
-
N
P
NNFG
D
F
K
Y
C
L
---------------
C
A
I
K
N
T
L
D
Y
L
--------
N
IE
P
-
K
T
G
F
K
I
N
I
S
S
K
I
--
P
I
S
C
G
L
G
S
S
A
S
I
T
I
G
T
I
K
A
V
S
G
F
Y
--
N
K
E
L
K
D
D
E
---------------
I
A
K
L
G
Y
M
V
E
K
E
I
Q
G
K
A
S
-
I
T
D
T
S
T
I
T
Y
K
---
G
---
I
-----
L
E
I
K
N
N
K
-------------------------------
F
R
K
I
K
G
E
F
E
E
F
L
K
N
C
K
F
L
I
V
Y
A
E
--
K
R
K
K
K
T
A
------------
E
-----
L
--------
V
-----------------------------------
N
E
------
V
A
K
-------
I
-------------
E
N
------
K
-------------------------------------------
D
----------------
E
I
----
F
-------------
K
E
I
D
---
K
V
I
------
D
E
--
A
L
K
I
K
N
K
E
D
F
G
-------
K
L
M
T
K
N
H
E
L
L
K
K
L
N
--------
I
S
T
-----
P
K
L
D
R
I
V
D
I
G
N
R
-
F
-
G
F
G
A
-
K
L
T
G
A
G
G
G
G
C
V
I
I
L
V
---------------------------------------------------------------------------------------
43
HHSearch
57.14
18%
-80
- C3 -
3V2U
4
GAL3_YEAST
C:
[39-486]
-------------------
D
F
I
A
R
S
P
G
R
V
N
L
I
G
E
H
I
D
Y
------
C
D
F
S
V
L
P
L
A
I
D
V
D
M
L
C
A
V
K
I
L
D
E
K
N
P
S
I
T
L
T
N
A
D
P
K
F
----
A
Q
-
R
K
F
D
L
---
P
L
D
G
S
Y
-
M
A
I
D
-
P
-
S
V
S
E
----
W
S
N
Y
F
K
---------------
C
G
L
H
V
A
H
S
Y
L
K
K
I
APERF
N
N-
T
-
P
L
-
V
G
A
Q
I
F
C
Q
S
D
I
P
T
G
G
G
L
S
S
A
F
T
C
A
A
A
L
A
T
-
I
R
A
N
M
GK
N
F
D
I
S
K
K
D
---------------
L
T
R
I
T
A
V
A
E
H
-
Y
V
G
V
N
N
G
G
M
D
Q
A
T
S
V
Y
G
---
E
EDH
A
---
L
Y
V
E
F
R
P
K
L
--
K
A
----------------------
T
P
F
K
F
P
Q
L
--
K
N
H
E
------
I
S
F
V
I
A
N
T
--
L
V
K
S
N
K
F
------------
E
TAPTN
Y
--------
N
L
R
V
I
E
V
T
V
A
A
N
A
L
A
T
R
Y
S
V
A
L
P
S
H
KDNSNSERGN
L
R
D
------
F
M
D
A
Y
-----
Y
-------------
A
R
YENQAQ
P
WNGD
I
G
T
G
I
E
R
L
L
K
M
L
Q
L
V
E
E
S
FSRKKSGFT
V
H
E
A
S
T
A
L
NCS
R
E
----------------
E
F
T
R
D
Y
L
TT
F
P
V
R
F
QVL---
K
L
Y
Q
---
R
A
K
H
V
Y
S
E
S
L
R
--
V
L
K
A
L
K
M
M
T
S
A
T
F
H
T
D
E
D
F
F
T
D
F
G
R
L
M
N
E
S
Q
A
S
C
D
K
L
Y
-
E
C
S
C
-----
I
E
T
N
Q
I
C
S
I
A
L
A
-
N
-
G
S
F
G
S
R
L
T
G
A
G
W
G
G
C
T
I
H
L
V
P
S
G
A
NGN
V
E
Q
V
R
K
A
L
I
-----------------------------------------------------------------------