@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0134: (2016-04-19 )
MIALPALEGVEHRHVDVAEGVRIHVADAGPADGPAVMLVHGFPQNWWEWRDLIGPLAADGNRVLCPDLRGAGWSSAPRSRYTKTEMADDLAAVLDGLGVAKVKLVAHDWGGPVAFIMMLRHPEKVTGFFGVNTVAPWVKRDLGMLRNMWRFWYQIPMSLPVIGPRVISDPKGRYFRLLTGWVGGGFRVPDDDVRLYLDCMREPGHAEAGSRWYRTFQTREMLRWLRGEYNDARVDVPVRWLHGTGDPVITPDLLDGYAERASDFEVELVDGVGHWIVEQRPELVLDRVRAFLAAGTEQRD
Atome Classification :
(27 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20...-.....30.........40........50........60........70......--.-----.80-.........90........-100.......110.......120.......130.--...--...---140----.-..-----...-..150-.......-.160.......170....-.-.-------------------------.180.-------....-.--.190---------...----------.....200.......210.....----..220-------......-..230--------........240.......-250........260.......270.......280.......290.......300
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIALPALEGVEHRHVDVAE
G
V
R
I
H
-
V
ADAGP-ADG
P
A
V
M
L
V
HGFPQ
N
W
W
E
W
R
D
L
IGPLAADG
N
R
V
LCPDLRGAGWSSAP--R-----SR--Y
T
K
T
E
M
A
D
D
L
A
A
V
L
DGLG
V
-
A
K
V
K
L
V
A
HDWG
G
P
V
A
F
I
M
M
LRHP
E
K
V
T
G
FFGVNT--V
A
P
--
W
V
K
---
R
D
-----
L
-
G
M
-----
L
R
N
-
M
W
R
-
F
-
W
Y
QIPMS-LPVIGPRVISDPKG
R
Y
F
R
-
L
-
L
-------------------------TGWVG-------GGFR-V--P
D
D
----------
D
V
R
----------
L
Y
L
D
C
MREPGH
A
E
A
G
S
R
W
Y
R
T
F
Q
----
T
R
E
M
--------
L
R
W
L
RG-EYND---------
A
R
V
D
V
P
V
R
W
LHGTGDPVI-
T
-
P
D
L
L
D
G
Y
A
E
RASD
F
E
V
E
L
VDGV
G
H
W
I
V
EQ
R
P
E
L
V
L
D
R
V
R
A
F
L
AAGTEQRD
2
PsiBlast_PDB
86.24
26%
-107
- C1 -
1CQZ
-
HYES_MOUSE
A:
[235-533]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
G
Y
V
T
V
K
P
G
I
R
L
H
-
F
V
E
M
G
---
S
G
P
A
L
C
L
C
H
G
F
P
E
S
W
F
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
F
R
V
L
A
I
D
M
K
G
Y
G
D
S
S
S
P
--
P
EI---
E
E
--
Y
A
M
E
L
L
C
K
E
M
V
T
F
L
D
K
L
G
I
-
P
Q
A
V
F
I
G
H
D
W
A
G
V
M
V
W
N
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
----
P
--
F
M
P
---
P
D
PDVS
P
M
-
K
V
-----
I
R
S
-
I
P
V
-
F
-
N
Y
Q
L
Y
F
Q
-
E
P
G
V
A
E
A
E
L
E
K
N
M
S
R
T
F
K
-
S
-
F
F
RASDE-------------------
T
G
F
I
A
VHKATEI
G
G
I
L
-
V
NT
P
E
D
PNLSKITT
E
E
E
I
E
----------
F
Y
I
Q
Q
F
K
K
T
G
F
-
R
G
P
L
N
W
Y
R
N
------
T
E
R
N
--------
W
K
W
-
S
C
-
K
G
L
G
---------
R
K
I
L
V
P
A
L
M
V
T
A
E
K
D
I
V
L
-
R
-
P
E
M
S
K
N
M
E
K
W
I
P
F
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
I
E
K
P
T
E
V
----------------
3
PsiBlast_PDB
85.88
26%
-104
- C1 -
1CR6
1
HYES_MOUSE
A:
[235-533]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
G
Y
V
T
V
K
P
G
I
R
L
H
-
F
V
E
M
G
---
S
G
P
A
L
C
L
C
H
G
F
P
E
S
W
F
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
F
R
V
L
A
I
D
M
K
G
Y
G
D
S
S
S
P
--
P
EI---
E
E
--
Y
A
M
E
L
L
C
K
E
M
V
T
F
L
D
K
L
G
I
-
P
Q
A
V
F
I
G
H
D
W
A
G
V
M
V
W
N
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
----
P
--
F
M
P
---
P
D
PDVS
P
M
-
K
V
-----
I
R
S
-
I
P
V
-
F
-
N
Y
Q
L
Y
F
Q
-
E
P
G
V
A
E
A
E
L
E
K
N
M
S
R
T
F
K
-
S
-
F
F
RASDE-------------------
T
G
F
I
A
VHKATEI
G
G
I
L
-
V
NT
P
E
D
PNLSKITT
E
E
E
I
E
----------
F
Y
I
Q
Q
F
K
K
T
G
F
-
R
G
P
L
N
W
Y
R
N
------
T
E
R
N
--------
W
K
W
-
S
C
-
K
G
L
G
---------
R
K
I
L
V
P
A
L
M
V
T
A
E
K
D
I
V
L
-
R
-
P
E
M
S
K
N
M
E
K
W
I
P
F
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
I
E
K
P
T
E
V
----------------
4
PsiBlast_PDB
83.88
26%
-108
- C1 -
1EK1
1
HYES_MOUSE
A:
[235-533]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
G
Y
V
T
V
K
P
G
I
R
L
H
-
F
V
E
M
G
---
S
G
P
A
L
C
L
C
H
G
F
P
E
S
W
F
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
F
R
V
L
A
I
D
M
K
G
Y
G
D
S
S
S
P
--
P
EI---
E
E
--
Y
A
M
E
L
L
C
K
E
M
V
T
F
L
D
K
L
G
I
-
P
Q
A
V
F
I
G
H
D
W
A
G
V
M
V
W
N
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
----
P
--
F
M
P
---
P
D
PDVS
P
M
-
K
V
-----
I
R
S
-
I
P
V
-
F
-
N
Y
Q
L
Y
F
Q
-
E
P
G
V
A
E
A
E
L
E
K
N
M
S
R
T
F
K
-
S
-
F
F
RASDE-------------------
T
G
F
I
A
VHKATEI
G
G
I
L
-
V
NT
P
E
D
PNLSKITT
E
E
E
I
E
----------
F
Y
I
Q
Q
F
K
K
T
G
F
-
R
G
P
L
N
W
Y
R
N
------
T
E
R
N
--------
W
K
W
-
S
C
-
K
G
L
G
---------
R
K
I
L
V
P
A
L
M
V
T
A
E
K
D
I
V
L
-
R
-
P
E
M
S
K
N
M
E
K
W
I
P
F
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
I
E
K
P
T
E
V
----------------
5
PsiBlast_PDB
83.74
26%
-108
- C1 -
1EK2
1
HYES_MOUSE
A:
[235-533]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
G
Y
V
T
V
K
P
G
I
R
L
H
-
F
V
E
M
G
---
S
G
P
A
L
C
L
C
H
G
F
P
E
S
W
F
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
F
R
V
L
A
I
D
M
K
G
Y
G
D
S
S
S
P
--
P
EI---
E
E
--
Y
A
M
E
L
L
C
K
E
M
V
T
F
L
D
K
L
G
I
-
P
Q
A
V
F
I
G
H
D
W
A
G
V
M
V
W
N
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
----
P
--
F
M
P
---
P
D
PDVS
P
M
-
K
V
-----
I
R
S
-
I
P
V
-
F
-
N
Y
Q
L
Y
F
Q
-
E
P
G
V
A
E
A
E
L
E
K
N
M
S
R
T
F
K
-
S
-
F
F
RASDE-------------------
T
G
F
I
A
VHKATEI
G
G
I
L
-
V
NT
P
E
D
PNLSKITT
E
E
E
I
E
----------
F
Y
I
Q
Q
F
K
K
T
G
F
-
R
G
P
L
N
W
Y
R
N
------
T
E
R
N
--------
W
K
W
-
S
C
-
K
G
L
G
---------
R
K
I
L
V
P
A
L
M
V
T
A
E
K
D
I
V
L
-
R
-
P
E
M
S
K
N
M
E
K
W
I
P
F
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
I
E
K
P
T
E
V
----------------
78
Fugue
82.39
28%
-93
- C1 -
1Y37
1
DEHA_BURSP
A:
[1-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
E
G
F
E
R
R
L
V
D
V
-
G
D
V
T
I
N
-
C
V
V
G
G
---
S
G
P
A
L
L
L
L
H
G
F
P
Q
N
L
H
M
W
A
R
V
A
P
L
L
A
-
N
E
Y
T
V
V
C
A
D
L
R
G
Y
G
G
S
S
K
P
--
V
GAPDH
A
N
--
Y
S
F
R
A
M
A
S
D
Q
R
E
L
M
R
T
L
G
F
-
E
R
F
H
L
V
G
H
D
R
G
G
R
T
G
H
R
M
A
L
D
H
P
D
S
V
L
S
L
A
V
L
D
I
IP
T
Y
V
--
M
F
E
---
E
V
-----
D
-
R
F
-----
V
A
R
-
A
Y
W
-
H
-
W
Y
F
L
Q
Q
P
-
A
P
Y
P
E
K
V
I
G
A
D
P
D
T
F
Y
E
G
-
C
-
L
-------------------------
F
G
W
G
A
-------
T
G
A
D
G
F
--
D
P
E
----------
Q
L
E
----------
E
Y
R
K
Q
W
R
D
P
A
A
I
H
G
S
C
C
D
Y
R
A
G
G
----
T
--
I
--------
D
F
E
L
D
H
-
G
D
L
G
---------
R
Q
V
Q
C
P
A
L
V
F
S
G
S
A
G
L
M
H
-
S
L
F
E
M
Q
V
V
W
A
P
R
L
A
N
M
R
F
A
S
L
P
G
-
G
H
F
F
V
D
R
F
P
D
D
T
A
R
I
L
R
E
F
L
S
D
A
R
S
---
64
HHSearch
81.64
25%
-90
- C1 -
4DM7
-
?
A:
[28-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
V
P
N
G
F
E
S
A
Y
R
E
-
V
D
G
V
K
L
H
-
Y
V
K
G
G
---
Q
G
P
L
V
M
L
V
H
G
F
G
Q
T
W
Y
E
W
H
Q
L
M
P
E
L
A
K
-
R
F
T
V
I
A
P
D
L
P
G
L
G
Q
S
E
P
P
--
K
-----
T
G
--
Y
S
G
E
Q
V
A
V
Y
L
H
K
L
A
R
Q
F
S
P
D
R
P
F
D
L
V
A
H
D
I
G
I
W
N
T
Y
P
M
V
V
K
N
Q
A
D
I
A
R
L
V
Y
M
D
A
--
P
I
P
--
D
A
R
---
I
Y
-----
R
F
P
A
-----
F
T
A
Q
G
E
S
L
V
-
W
H
F
S
F
F
A
A
D
D
R
L
A
E
T
L
I
A
G
K
E
R
F
F
L
E
-
H
F
I
-------------------------
K
S
H
A
S
-------
N
T
E
V
-
F
--
S
E
R
----------
L
L
D
----------
L
Y
A
R
S
Y
A
K
P
H
S
L
N
A
S
F
E
Y
Y
R
A
L
N
------
E
S
--------
V
R
Q
-
N
A
-
E
L
A
K
---------
T
R
L
Q
M
P
T
M
T
L
A
G
G
G
H
G
G
M
-
G
-
T
F
Q
L
E
Q
M
K
A
Y
A
E
D
V
E
G
H
V
L
P
G
C
G
H
W
L
P
E
E
C
A
A
P
M
N
R
L
V
I
D
F
L
S
R
G
R
----
61
HHSearch
81.33
25%
-100
- C1 -
3G9X
3
DHAA_RHOSO
A:
[8-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
F
D
P
H
Y
V
E
V
-
L
G
E
R
M
H
-
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
-
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
P
--
D
-----
L
D
--
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
-
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
E
F
--
I
R
P
--
F
P
T
---
W
D
-----
E
-
W
------
P
-
E
-
F
A
R
-
E
-
T
F
Q
-
A
F
R
-
T
A
D
V
G
R
E
L
I
I
D
Q
-
N
A
F
I
E
G
A
-
L
-------------------------
P
K
C
V
V
---------
R
P
-
L
--
T
E
V
----------
E
M
D
----------
H
Y
R
E
P
F
L
K
P
V
D
R
E
P
L
W
R
F
P
N
E
L
P
IAGE
P
A
N
I
--------
V
A
L
V
E
A
Y
M
N
W
L
---------
H
Q
S
P
V
P
K
L
L
F
W
G
T
P
G
V
L
I
-
P
-
P
A
E
A
A
R
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
R
W
L
P
A
L
H
----
9
PsiBlast_PDB
78.53
25%
-102
- C1 -
1ZD3
2
HYES_HUMAN
A:
[237-534]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
-
F
V
E
L
G
---
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
--
P
EI---
E
E
--
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
-
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
----
P
--
F
I
P
---
A
N
-----
P
-
N
M
S
P
L
E
S
I
K
A
-
N
P
V
-
F
-
D
Y
Q
L
Y
F
Q
-
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
-
S
-
L
---------------------------------------
F
R
-
A
--
S
D
E
----------
S
V
L
SMHKVCEAGG
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
----
V
Q
Q
F
K
K
SGF
R
G
P
L
N
W
Y
R
N
-
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
-
V
-
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
----------------
81
Fugue
78.10
24%
-97
- C1 -
1EK1
1
HYES_MOUSE
A:
[4-544]
R
V
A
A
F
D
LDGVLALPSIGPTEQLMKGKITFSQWVPLQIFSQAMAARSIN
R
P
M
L
Q
A
A
I
A
L
K
K
K
G
F
T
T
C
I
VTN
N
W
L
D
DGDK
R
D
S
L
A
Q
M
M
C
E
L
SQHFD
F
L
I
E
SCQVGMIKPEP
Q
I
Y
N
F
L
L
D
T
LKAKPNE
V
V
F
L
D
DFGSNL
K
P
A
R
D
M
GMV
T
I
L
V
HNTASALRELEKVTG
T
Q
F
P
E
AP
L
P
V
P
C
N
P
N
D
V
S
H
G
Y
V
T
V
K
P
G
I
R
L
H
-
F
V
E
M
G
---
S
G
P
A
L
C
L
C
H
G
F
P
E
S
W
F
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
F
R
V
L
A
I
D
M
K
G
Y
G
D
S
S
S
P
PE
I
-----
E
E
--
Y
A
M
E
L
L
C
K
E
M
V
T
F
L
D
K
L
G
I
-
P
Q
A
V
F
I
G
H
D
W
A
G
V
M
V
W
N
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
--
P
F
M
--
P
P
D
PDV
S
P
-----
M
-
K
V
-----
I
R
S
-
I
P
V
-
F
-
N
Y
Q
L
Y
F
Q
-
E
P
G
V
A
E
A
E
L
E
K
N
M
S
R
T
F
K
-
S
-
F
F
RASDETGFIAVHKATEIGGILVNT
P
E
D
P
N
-------
L
S
K
I
-
T
--
T
E
E
----------
E
I
E
----------
F
Y
I
Q
Q
F
K
K
T
G
-
F
R
G
P
L
N
W
Y
R
N
T
E
----
R
N
W
K
--------
W
S
---
C
-
K
G
L
G
---------
R
K
I
L
V
P
A
L
M
V
T
A
E
K
D
I
V
L
-
R
-
P
E
M
S
K
N
M
E
K
W
I
P
F
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
I
E
K
P
T
E
V
N
Q
I
L
I
K
W
L
Q
T
E
-----
1
PsiBlast_PDB
77.95
27%
-97
* C1 *
1EHY
1
?
A:
[7-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
H
Y
E
V
Q
L
P
D
-
V
K
I
H
-
Y
V
R
E
G
A
---
G
P
T
L
L
L
L
H
G
W
P
G
F
W
W
E
W
S
K
V
I
G
P
L
A
E
H
Y
D
-
V
I
V
P
D
L
R
G
F
G
D
S
E
K
P
--
D
LNDL-
S
K
--
Y
S
L
D
K
A
A
D
D
Q
A
A
L
L
D
A
L
G
I
-
E
K
A
Y
V
V
G
H
D
F
A
A
I
V
L
H
K
F
I
R
K
Y
S
D
R
V
I
K
A
A
I
F
D
P
--
I
Q
P
DF------------------------
E
-
S
W
Y
-
S
Q
F
H
Q
L
D
M
A
-
V
E
V
V
G
S
S
--
R
E
V
C
K
K
Y
F
K
H
F
-
F
-------------------------
D
H
W
S
Y
-------
R
D
E
L
-
L
--
T
E
E
----------
E
L
E
----------
V
H
V
D
N
C
M
K
P
D
N
I
H
G
G
F
N
Y
Y
R
A
N
I
----
R
P
D
A
--------
A
L
W
--
T
-
D
L
D
H
---------
T
M
S
D
L
P
V
T
M
I
W
G
L
G
D
T
C
V
P
Y
-
A
P
L
I
E
F
V
P
K
Y
Y
S
N
Y
T
M
E
T
I
E
D
C
G
H
F
L
M
V
E
K
P
E
I
A
I
D
R
I
K
T
----------
12
PsiBlast_PDB
77.20
25%
-100
- C1 -
3I1Y
1
HYES_HUMAN
A:
[237-534]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
-
F
V
E
L
G
---
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
--
P
EI---
E
E
--
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
-
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
----
P
--
F
I
P
---
A
N
-----
P
-
N
M
S
P
L
E
S
I
K
A
-
N
P
V
-
F
-
D
Y
Q
L
Y
F
Q
-
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
-
S
-
L
---------------------------------------
F
R
-
A
--
S
D
E
----------
S
V
L
SMHKVCEAGG
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
----
V
Q
Q
F
KKSGF
R
G
P
L
N
W
Y
R
N
-
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
-
V
-
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
----------------
14
PsiBlast_PDB
77.08
25%
-98
- C1 -
3KOO
1
HYES_HUMAN
A:
[237-534]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
-
F
V
E
L
G
---
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
--
P
EI---
E
E
--
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
-
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
----
P
--
F
I
P
---
A
N
-----
P
-
N
M
S
P
L
E
S
I
K
A
-
N
P
V
-
F
-
D
Y
Q
L
Y
F
Q
-
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
-
S
-
L
---------------------------------------
F
R
-
A
--
S
D
E
----------
S
V
L
SMHKVCEAGG
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
----
V
Q
Q
F
KKSGF
R
G
P
L
N
W
Y
R
N
-
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
-
V
-
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
----------------
11
PsiBlast_PDB
77.03
25%
-99
- C1 -
1ZD5
1
HYES_HUMAN
A:
[237-534]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
-
F
V
E
L
G
---
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
--
P
EI---
E
E
--
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
-
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
----
P
--
F
I
P
---
A
N
-----
P
-
N
M
S
P
L
E
S
I
K
A
-
N
P
V
-
F
-
D
Y
Q
L
Y
F
Q
-
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
-
S
-
L
---------------------------------------
F
R
-
A
--
S
D
E
----------
S
V
L
SMHKVCEAGG
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
----
V
Q
Q
F
KKSGF
R
G
P
L
N
W
Y
R
N
-
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
-
V
-
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
----------------
6
PsiBlast_PDB
76.44
25%
-100
- C1 -
1S8O
1
HYES_HUMAN
A:
[237-534]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
-
F
V
E
L
G
---
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
--
P
EI---
E
E
--
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
-
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
----
P
--
F
I
P
---
A
N
-----
P
-
N
M
S
P
L
E
S
I
K
A
-
N
P
V
-
F
-
D
Y
Q
L
Y
F
Q
-
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
-
S
-
L
---------------------------------------
F
R
-
A
--
S
D
E
----------
S
V
L
SMHKVCEAGG
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
----
V
Q
Q
F
KKSGF
R
G
P
L
N
W
Y
R
N
-
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
-
V
-
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
----------------
10
PsiBlast_PDB
76.31
25%
-99
- C1 -
1ZD4
1
HYES_HUMAN
A:
[237-534]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
-
F
V
E
L
G
---
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
--
P
EI---
E
E
--
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
-
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
----
P
--
F
I
P
---
A
N
-----
P
-
N
M
S
P
L
E
S
I
K
A
-
N
P
V
-
F
-
D
Y
Q
L
Y
F
Q
-
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
-
S
-
L
---------------------------------------
F
R
-
A
--
S
D
E
----------
S
V
L
SMHKVCEAGG
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
----
V
Q
Q
F
KKSGF
R
G
P
L
N
W
Y
R
N
-
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
-
V
-
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
----------------
7
PsiBlast_PDB
76.29
25%
-94
- C1 -
1VJ5
2
HYES_HUMAN
A:
[237-534]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
-
F
V
E
L
G
---
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
--
P
EI---
E
E
--
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
-
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
----
P
--
F
I
P
---
A
N
-----
P
-
N
M
S
P
L
E
S
I
K
A
-
N
P
V
-
F
-
D
Y
Q
L
Y
F
Q
-
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
-
S
-
L
---------------------------------------
F
R
-
A
--
S
D
E
----------
S
V
L
SMHKVCEAGG
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
----
V
Q
Q
F
KKSGF
R
G
P
L
N
W
Y
R
N
-
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
-
V
-
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
----------------
15
PsiBlast_PDB
76.10
25%
-97
- C1 -
3OTQ
1
HYES_HUMAN
A:
[237-534]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
-
F
V
E
L
G
---
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
--
P
EI---
E
E
--
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
-
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
----
P
--
F
I
P
---
A
N
-----
P
-
N
M
S
P
L
E
S
I
K
A
-
N
P
V
-
F
-
D
Y
Q
L
Y
F
Q
-
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
-
S
-
L
---------------------------------------
F
R
-
A
--
S
D
E
----------
S
V
L
SMHKVCEAGG
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
----
V
Q
Q
F
KKSGF
R
G
P
L
N
W
Y
R
N
-
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
-
V
-
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
----------------
17
PsiBlast_PDB
76.04
25%
-96
- C1 -
4J03
1
HYES_HUMAN
A:
[237-534]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
-
F
V
E
L
G
---
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
--
P
EI---
E
E
--
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
-
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
----
P
--
F
I
P
---
A
N
-----
P
-
N
M
S
P
L
E
S
I
K
A
-
N
P
V
-
F
-
D
Y
Q
L
Y
F
Q
-
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
-
S
-
L
---------------------------------------
F
R
-
A
--
S
D
E
----------
S
V
L
SMHKVCEAGG
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
----
V
Q
Q
F
KKSGF
R
G
P
L
N
W
Y
R
N
-
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
-
V
-
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
----------------
13
PsiBlast_PDB
75.80
25%
-99
- C1 -
3I28
1
HYES_HUMAN
A:
[237-534]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
-
F
V
E
L
G
---
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
--
P
EI---
E
E
--
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
-
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
----
P
--
F
I
P
---
A
N
-----
P
-
N
M
S
P
L
E
S
I
K
A
-
N
P
V
-
F
-
D
Y
Q
L
Y
F
Q
-
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
-
S
-
L
---------------------------------------
F
R
-
A
--
S
D
E
----------
S
V
L
SMHKVCEAGG
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
----
V
Q
Q
F
KKSGF
R
G
P
L
N
W
Y
R
N
-
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
-
V
-
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
----------------
20
PsiBlast_PDB
75.79
25%
-97
- C1 -
3WK4
1
HYES_HUMAN
A:
[237-534]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
-
F
V
E
L
G
---
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
--
P
EI---
E
E
--
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
-
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
----
P
--
F
I
P
---
A
N
-----
P
-
N
M
S
P
L
E
S
I
K
A
-
N
P
V
-
F
-
D
Y
Q
L
Y
F
Q
-
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
-
S
-
L
---------------------------------------
F
R
-
A
--
S
D
E
----------
S
V
L
SMHKVCEAGG
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
----
V
Q
Q
F
K
K
SGF
R
G
P
L
N
W
Y
R
N
-
M
E
R
N
W
K
W
A
C
K
S
LG
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
-
V
-
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
----------------
21
PsiBlast_CBE
49.12
42%
-105
- C1 -
2ZJF
3
?
A:
[11-142]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
R
I
L
N
-
C
R
G
T
R
I
H
A
V
A
D
S
P
P
D
Q
Q
G
P
L
V
V
L
L
H
G
F
P
E
S
W
Y
S
W
R
H
Q
I
P
A
L
A
G
A
G
Y
R
V
V
A
I
D
Q
R
G
Y
G
R
S
S
K
Y
--
R
-----
V
Q
KA
Y
R
I
K
E
L
V
G
D
V
V
G
V
L
D
S
Y
G
A
-
E
Q
A
F
V
V
G
H
D
W
G
A
P
V
A
W
T
F
A
W
L
H
P
D
R
C
A
G
V
V
G
I
S
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
44.54
37%
-116
- C1 -
3FBW
5
?
A:
[19-134]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
M
H
-
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
-
P
H
V
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
P
--
D
-----
L
D
--
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
-
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
E
F
--
I
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
41.60
36%
-114
- C1 -
4F5Z
2
DHAA_RHORH
A:
[19-134]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
M
H
-
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
-
P
H
V
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
P
--
D
-----
L
D
--
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
V
G
L
-
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
E
F
--
I
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
40.12
39%
-112
- C1 -
4KAC
2
DHAA_RHOSO
B:
[34-136]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
-
P
H
V
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
P
--
D
-----
L
D
--
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
-
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
40.09
39%
-117
- C1 -
4KYV
3
?
B:
[34-137]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
-
P
H
V
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
P
--
D
-----
L
D
--
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
-
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
39.76
39%
-114
- C1 -
4KYV
3
?
A:
[34-137]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
-
P
H
V
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
P
--
D
-----
L
D
--
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
-
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
38.39
39%
-109
- C1 -
4KAC
1
DHAA_RHOSO
A:
[34-136]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-
Y
V
D
V
G
P
-
R
D
G
T
P
V
L
F
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
-
P
H
V
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
P
--
D
-----
L
D
--
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
-
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
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G
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