@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0536: (2016-04-23 )
MRVLLTGAAGFIGSRVDAALRAAGHDVVGVDALLPAAHGPNPVLPPGCQRVDVRDASALAPLLAGVDLVCHQAAMVGAGVNAADAPAYGGHNDFATTVLLAQMFAAGVRRLVLASSMVVYGQGRYDCPQHGPVDPLPRRRADLDNGVFEHRCPGCGEPVIWQLVDEDAPLRPRSLYAASKTAQEHYALAWSEASGGSVVALRYHNVYGPGMPRDTPYSGVAAIFRSAVEKGKPPKVFEDGGQMRDFVHVDDVAAANLAAVHLGEADRDGFTAVNVCSGRPISILQVATAICDARGGSMSPAITGHYRSGDVRHIVADPARAARVLGFRAAVDPGEGLREFAFAPLR
Atome Classification :
(20 SA)
-.........10........20...--.------....30--------------...-.....40-.------.-.--..--..--.----50-----........60.--..--.---.--...70........80........90........100....-----...110....-.-.-.120.-...----...130.......140.......150.......160.......170.......180.......190.-...--...200......---.-------210---..------....--..220.......230.....------.------.240.......250.......260......---.270.......280.......290...-----..--..300.--..-------....310.......320......-.330.......340....-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-
M
R
V
L
L
TGAA
G
F
I
G
S
R
V
D
A
A
L
R
AAG--H------
D
V
V
G
V
D
--------------
A
L
L-PAAHGPN-P------V-L--PP--GC--
Q
----
R
V-----DVR
D
A
S
A
L
A
P
L
--
L
A
--
G
---
V
--
D
L
V
C
H
Q
A
A
M
VGAGVNAADAPAYGGH
N
D
F
A
T
T
V
L
L
A
Q
M
F
A
A
-----
G
V
R
R
L
V
L
AS
S
-
M
-
V
-
V
YGQG-RYD----CPQHGPVDPLP
R
R
RADLDNG
V
F
EHRCPGCGEP
V
I
W
Q
LVDEDAPLRP
R
S
L
YAASKTAQ
E
H
Y
A
L
A
W
SEA-SG
G
--
S
V
V
A
L
R
Y
HNVYG---P-------GM----PR------DTP
Y
--
S
G
V
A
A
I
F
R
S
A
V
EKGKPPKVF------E------DGGQ
M
R
D
F
V
HVDDVAAA
N
L
A
A
V
HLGEADRD---G
F
T
A
V
NVCSGRP
I
S
I
L
Q
V
A
T
A
I
C
DARG-----GS--MS
P
A
I
T
--
G
H-------YRSGD
V
R
H
IVA
D
P
A
R
A
A
R
V
L
G
F
R
-AAVDP
G
E
G
L
R
E
FAFAPLR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
93.71
31%
-103
- C1 -
2P5Y
1
?
A:
[1-301]
-
M
R
V
L
V
T
G
G
A
G
F
I
G
S
H
I
V
E
D
L
L
A
R
G
--
L
------
E
V
A
V
L
D
--------------
N
L
----
A
T
G
K
R
-
E
------
N
-
V
--
P
K
--
G
V
--
P
FF--
R
V
-----
D
L
R
D
K
E
G
V
E
R
A
--
F
R
--
E
---
F
RP
T
H
V
S
H
Q
A
A
Q
A
S
V
K
V
S
V
E
D
-
P
V
L
----
D
F
E
V
N
L
L
G
G
L
N
L
L
E
A
C
R
Q
Y
G
V
E
K
L
V
F
A
S
T
G
G
-
A
-
I
Y
G
-----
E
----
V
P
E
G
-------------------------------
E
R
A
E
E
T
W
P
P
R
P
K
S
P
Y
A
A
S
K
A
A
F
E
H
Y
L
S
V
Y
G
Q
S
-
Y
G
L
--
K
W
V
S
L
R
Y
G
N
V
Y
G
-----------------
P
R
------
Q
D
P
H
GE
A
G
V
V
A
I
F
A
E
R
V
L
K
G
L
P
V
T
L
Y
------
A
RKTPG-
D
E
G
C
V
R
D
Y
V
Y
V
G
D
V
A
E
A
H
A
L
A
L
F
S
L
E
G
---------
I
Y
N
V
G
T
G
E
G
H
T
T
R
E
V
L
M
A
V
A
E
A
A
G
-----
K
A
P
E
V
Q
P
A
P
P
------------
R
P
G
D
L
E
R
S
V
L
S
P
L
K
L
M
-
A
H
G
W
R
-
P
K
V
G
F
Q
E
G
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
92.41
31%
-99
- C1 -
2P5U
1
?
D:
[1-301]
-
M
R
V
L
V
T
G
G
A
G
F
I
G
S
H
I
V
E
D
L
L
A
R
G
--
L
------
E
V
A
V
L
D
--------------
N
L
----
A
T
G
K
R
-
E
------
N
-
V
--
P
K
--
G
V
--
P
FF--
R
V
-----
D
L
R
D
K
E
G
V
E
R
A
--
F
R
--
E
---
F
RP
T
H
V
S
H
Q
A
A
Q
A
S
V
K
V
S
V
E
D
-
P
V
L
----
D
F
E
V
N
L
L
G
G
L
N
L
L
E
ACRQY
G
V
E
K
L
V
F
A
S
T
G
G
-
A
-
I
Y
G
-----
E
----
V
P
E
G
-------------------------------
E
R
A
E
E
T
W
P
P
R
P
K
S
P
Y
A
A
S
K
A
A
F
E
H
Y
L
S
V
Y
G
Q
S
-
Y
G
L
--
K
W
V
S
L
R
Y
G
N
V
Y
G
-----------------
P
R
------
Q
D
P
H
GE
A
G
V
V
A
I
F
A
E
R
V
L
K
G
L
P
V
T
L
Y
------
A
RKTPG-
D
E
G
C
V
R
D
Y
V
Y
V
G
D
V
A
E
A
H
A
L
A
L
F
S
L
E
G
---------
I
Y
N
V
G
T
G
E
G
H
T
T
R
E
V
L
M
A
V
A
E
A
A
G
-----
K
A
PE
V
Q
P
A
P
P
------------
R
P
G
D
L
E
R
S
V
L
S
P
L
K
L
M
-
A
H
G
W
R
-
P
K
V
G
F
Q
E
G
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
92.20
31%
-102
- C1 -
2P5U
1
?
B:
[1-301]
-
M
R
V
L
V
T
G
G
A
G
F
I
G
S
H
I
V
E
D
L
L
A
R
G
--
L
------
E
V
A
V
L
D
--------------
N
L
----
A
T
G
K
R
-
E
------
N
-
V
--
P
K
--
G
V
--
P
FF--
R
V
-----
D
L
R
D
K
E
G
V
E
R
A
--
F
R
--
E
---
F
RP
T
H
V
S
H
Q
A
A
Q
A
S
V
K
V
S
V
E
D
-
P
V
L
----
D
F
E
V
N
L
L
G
G
L
N
L
L
E
ACRQY
G
V
E
K
L
V
F
A
S
T
G
G
-
A
-
I
Y
G
-----
E
----
V
P
E
G
-------------------------------
E
R
A
E
E
T
W
P
P
R
P
K
S
P
Y
A
A
S
K
A
A
F
E
H
Y
L
S
V
Y
G
Q
S
-
Y
G
L
--
K
W
V
S
L
R
Y
G
N
V
Y
G
-----------------
P
R
------
Q
D
P
H
GE
A
G
V
V
A
I
F
A
E
R
V
L
K
G
L
P
V
T
L
Y
------
A
RKTPG-
D
E
G
C
V
R
D
Y
V
Y
V
G
D
V
A
E
A
H
A
L
A
L
F
S
L
E
G
---------
I
Y
N
V
G
T
G
E
G
H
T
T
R
E
V
L
M
A
V
A
E
A
A
G
-----
K
A
PE
V
Q
P
A
P
P
------------
R
P
G
D
L
E
R
S
V
L
S
P
L
K
L
M
-
A
H
G
W
R
-
P
K
V
G
F
Q
E
G
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
91.37
31%
-97
- C1 -
2P5U
1
?
C:
[1-301]
-
M
R
V
L
V
T
G
G
A
G
F
I
G
S
H
I
V
E
D
L
L
A
R
G
--
L
------
E
V
A
V
L
D
--------------
N
L
----
A
T
G
K
R
-
E
------
N
-
V
--
P
K
--
G
V
--
P
FF--
R
V
-----
D
L
R
D
K
E
G
V
E
R
A
--
F
R
--
E
---
F
RP
T
H
V
S
H
Q
A
A
Q
A
S
V
K
V
S
V
E
D
-
P
V
L
----
D
F
E
V
N
L
L
G
G
L
N
L
L
E
ACRQY
G
V
E
K
L
V
F
A
S
T
G
G
-
A
-
I
Y
G
-----
E
----
V
P
E
G
-------------------------------
E
R
A
E
E
T
W
P
P
R
P
K
S
P
Y
A
A
S
K
A
A
F
E
H
Y
L
S
V
Y
G
Q
S
-
Y
G
L
--
K
W
V
S
L
R
Y
G
N
V
Y
G
-----------------
P
R
------
Q
D
P
H
GE
A
G
V
V
A
I
F
A
E
R
V
L
K
G
L
P
V
T
L
Y
------
A
RKTPG-
D
E
G
C
V
R
D
Y
V
Y
V
G
D
V
A
E
A
H
A
L
A
L
F
S
L
E
G
---------
I
Y
N
V
G
T
G
E
G
H
T
T
R
E
V
L
M
A
V
A
E
A
A
G
-----
K
A
PE
V
Q
P
A
P
P
------------
R
P
G
D
L
E
R
S
V
L
S
P
L
K
L
M
-
A
H
G
W
R
-
P
K
V
G
F
Q
E
G
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
91.26
31%
-96
- C1 -
2P5U
1
?
A:
[1-301]
-
M
R
V
L
V
T
G
G
A
G
F
I
G
S
H
I
V
E
D
L
L
A
R
G
--
L
------
E
V
A
V
L
D
--------------
N
L
----
A
T
G
K
R
-
E
------
N
-
V
--
P
K
--
G
V
--
P
F
F
--
R
V
-----
D
L
R
D
K
E
G
V
E
R
A
--
F
R
--
E
---
F
RP
T
H
V
S
H
Q
A
A
Q
A
S
V
K
V
S
V
E
D
-
P
V
L
----
D
F
E
V
N
L
L
G
G
L
N
L
L
E
A
C
R
Q
Y
G
V
E
K
L
V
F
A
S
T
G
G
-
A
-
I
Y
G
-----
E
----
V
P
E
G
-------------------------------
E
R
A
E
E
T
W
P
P
R
P
K
S
P
Y
A
A
S
K
A
A
F
E
H
Y
L
S
V
Y
G
Q
S
-
Y
G
L
--
K
W
V
S
L
R
Y
G
N
V
Y
G
-----------------
P
R
------
Q
D
P
H
GE
A
G
V
V
A
I
F
A
E
R
V
L
K
G
L
P
V
T
L
Y
------
A
RKTPG-
D
E
G
C
V
R
D
Y
V
Y
V
G
D
V
A
E
A
H
A
L
A
L
F
S
L
E
G
---------
I
Y
N
V
G
T
G
E
G
H
T
T
R
E
V
L
M
A
V
A
E
A
A
G
-----
K
A
P
E
V
Q
P
A
P
P
------------
R
P
G
D
L
E
R
S
V
L
S
P
L
K
L
M
-
A
H
G
W
R
-
P
K
V
G
F
Q
E
G
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
90.66
28%
-98
- C1 -
1Z45
5
GAL10_YEAST
A:
[11-699]
S
K
I
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
V
E
L
I
E
N
G
--
Y
------
D
C
V
V
A
D
NLSNSTY-------
D
S
V
-
A
R
L
E
V
L
T
-
K
------
H
-
H
--
I
P
---
F
--
Y
----
E
V
-----
D
L
C
D
R
K
G
L
E
K
V
--
F
K
E
Y
K
---
I
--
D
S
V
I
H
F
A
G
L
K
A
V
G
E
S
T
Q
I
P
L
R
Y
Y
H
N
N
I
L
G
T
V
V
L
L
E
L
M
Q
Q
Y
-----
N
V
S
K
F
V
F
S
S
S
-
A
-
T
-
V
Y
G
-----
D
----
A
T
R
F
P
N
M
I
P
I
P
----------------------------
E
E
C
P
L
G
P
T
N
P
Y
G
H
T
K
Y
A
I
E
N
I
L
N
D
L
Y
N
S
-
D
K
K
S
W
K
F
A
I
L
R
Y
F
N
P
I
G
---
A
HPSGLIG
E
D
----
P
L
------
G
I
P
N
--
N
L
L
P
Y
M
A
Q
V
A
V
G
R
R
E
K
L
Y
I
F
------
R
------
D
G
T
P
I
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
Q
Y
L
E
A
Y
N
E
N
E
G
L
C
R
E
W
N
L
G
S
G
K
G
S
T
V
F
E
V
Y
H
A
F
C
K
A
S
G
-----
I
D
--
L
P
Y
V
L
N
-------------------
L
T
A
K
P
D
R
A
K
R
E
L
K
W
Q
-
T
E
L
Q
V
E
D
S
C
K
D
L
W
K
W
T
T
E
N
P
FGYQLRG
V
E
A
R
F
SAEDMRYDA
R
F
V
T
I
GAGTR
F
Q
A
T
F
A
NLGASIV
D
L
K
V
NGQSV
V
L
G
Y
EN
E
E
G
Y
L
NPDSAYIGATIGRYANRISKG
K
F
S
L
CN
K
D
Y
Q
L
TVNNGVNANHSSIGSFHR
K
R
F
L
G
P
I
I
Q
NPSKD
V
F
T
A
E
Y
M
L
I
D
N
EKDTEFP
G
D
L
L
V
T
I
Q
Y
T
V
N
VAQK
S
L
E
I
V
Y
K
G
K
L
TAGE
A
T
P
I
N
L
T
N
H
S
Y
F
N
LNKPYGDTIEG
T
E
I
M
V
RSK
K
S
V
D
V
D
KNMIPTG
N
I
V
D
R
EIATFNSTK
P
T
V
L
G
PKNP
Q
F
D
C
C
F
V
VDENAKPSQINTLNNELTLI
V
K
A
F
H
PDSN
I
T
L
E
V
L
S
TEP
T
Y
Q
F
Y
TGDFLSAGYEARQ
G
F
A
I
E
P
G
RYIDAINQENWKDCVTLKNG
E
T
Y
G
S
K
I
V
Y
R
F
S
37
HHSearch
87.51
30%
-96
- C1 -
1R6D
2
?
A:
[1-310]
-
M
R
L
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
A
--
Y
PDVPAD
E
V
I
V
L
D
--------------
S
L
T
-
Y
A
G
N
R
A
N
-
L
AP----
V
D
A
--
D
P
--
R
L
R
F
V
----
H
G
-----
D
I
R
D
A
G
L
L
A
R
E
--
L
R
--
G
---
V
--
D
A
I
V
H
F
A
A
E
S
H
V
D
R
S
I
A
G
A
S
V
F
T
E
T
N
V
Q
G
T
Q
T
L
L
Q
C
A
V
D
A
-----
G
V
G
R
V
V
H
V
S
T
-
N
-
Q
-
V
Y
G
S
I
-
D
----------------------------------------
S
G
S
W
T
E
S
S
P
L
E
P
N
S
P
Y
A
A
S
K
A
G
S
D
L
V
A
R
A
Y
H
R
T
-
Y
G
L
--
D
V
R
I
T
R
C
C
N
N
Y
G
---
P
-------
Y
Q
----
H
P
------
E
K
-----
L
I
P
L
F
V
T
-
N
L
L
D
G
G
T
L
P
L
Y
------
G
------
D
G
A
N
V
R
E
W
V
H
T
D
D
H
C
R
G
I
A
L
V
L
A
---
G
-
G
R
---
A
G
E
I
Y
H
I
G
G
G
L
E
L
T
N
R
E
L
T
G
I
L
L
D
S
L
G
-----
A
D
--
W
S
S
V
R
K
--
V
A
-------
D
R
K
G
H
D
L
R
Y
S
L
D
G
G
K
I
E
R
E
L
G
Y
R
-
P
Q
V
S
F
A
D
G
L
A
R
T
V
R
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
86.04
29%
-92
* C1 *
4ZRM
3
?
A:
[4-306]
-
M
N
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
N
G
--
Y
------
G
V
I
V
V
D
--------------
N
L
S
-
S
G
K
V
E
-
N
-
L
------
N
-
R
--
N
A
--
L
F
--
Y
----
E
Q
-----
S
I
E
D
E
E
M
M
E
R
I
--
F
S
L
H
R
---
P
--
E
Y
V
F
H
L
A
A
Q
A
S
V
A
I
S
V
R
E
P
A
R
D
A
K
T
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
-----
G
V
K
K
F
I
F
S
S
T
-
G
-
G
A
I
Y
G
E
N
-
V
K
---------------------------------------
V
F
P
T
P
E
T
E
I
P
H
P
I
S
P
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
F
F
A
R
E
-
Y
G
L
--
K
Y
T
V
L
R
Y
A
N
V
Y
G
---
P
-------
R
Q
----
D
P
------
Y
G
E
---
A
G
V
V
A
I
F
T
E
R
M
L
R
G
E
E
V
H
I
F
------
G
------
D
G
E
Y
V
R
D
Y
V
Y
V
D
D
V
V
R
A
N
L
L
A
M
E
---
K
--
G
---
D
N
E
V
F
N
I
G
T
G
R
G
T
T
V
N
Q
L
F
K
L
L
K
E
I
T
G
-----
Y
D
--
K
E
P
V
Y
K
---
P
-------
P
R
K
G
D
V
R
K
S
I
L
D
Y
T
K
A
K
E
K
L
G
W
E
-
P
K
V
S
L
E
E
G
L
K
L
T
V
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
83.56
24%
-96
- C1 -
2HUN
1
?
A:
[4-310]
-
M
K
L
L
V
T
G
G
M
G
F
I
G
S
N
F
I
R
Y
I
L
E
K
H
P
D
W
------
E
V
I
N
I
D
--------------
K
L
G
-
Y
G
S
N
P
A
N
L
K
------
D
-
L
ED
D
P
--
R
Y
T
F
V
----
K
G
-----
D
V
A
D
Y
E
L
V
K
E
L
--
V
R
--
K
---
V
--
D
G
V
V
H
L
A
A
E
S
H
V
D
R
S
I
S
S
P
E
I
F
L
H
S
N
V
I
G
T
Y
T
L
L
E
S
I
R
R
E
N----
P
E
V
R
F
V
H
V
S
T
-
D
-
E
-
V
Y
G
D
I
-
L
K
----------------------------------------
G
S
F
T
E
N
D
R
L
M
P
S
S
P
Y
S
A
T
K
A
A
S
D
M
L
V
L
G
W
T
R
T
-
Y
N
L
--
N
A
S
I
T
R
C
T
N
N
Y
G
---
P
-------
Y
Q
----
F
P
------
E
K
-----
L
I
P
K
T
I
I
R
-
A
S
L
G
L
K
I
P
I
Y
------
G
------
T
---
V
R
D
W
L
Y
V
E
D
H
V
R
A
I
E
L
V
L
L
K
----
G
E
---
S
R
E
I
Y
N
I
S
A
G
E
E
K
T
N
L
E
V
V
K
I
I
L
R
L
M
G
-----
K
G
--
E
E
L
I
E
L
--
V
E
-------
D
R
P
G
H
D
L
R
Y
S
L
D
S
W
K
I
T
R
D
L
K
W
R
-
P
K
Y
T
F
D
E
G
I
K
K
T
I
D
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
83.17
26%
-91
- C1 -
3KO8
2
?
A:
[1-303]
-
M
R
I
V
V
T
G
G
A
G
F
I
G
S
H
L
V
D
K
L
V
E
L
G
--
Y
------
E
V
V
V
V
D
--------------
N
L
----
S
S
G
R
R
-
E
------
F
-
V
--
N
P
--
S
A
--
E
-----
L
-----
H
V
R
D
L
K
D
Y
S
-
W
--
G
A
--
G
---
I
KG
D
V
V
F
H
F
A
A
N
P
E
V
R
L
S
T
T
E
P
I
V
H
F
N
E
N
V
V
A
T
F
N
V
L
E
W
A
R
Q
T
-----
G
V
R
T
V
V
F
A
S
S
-
S
-
T
-
V
Y
G
D
A
-------------
D
V
I
P
T
P
----------------------------
E
E
E
P
Y
K
P
I
S
V
Y
G
A
A
K
A
A
G
E
V
M
C
A
T
Y
A
R
L
-
F
G
V
--
R
C
L
A
V
R
Y
A
N
V
V
G
---
P
-------
R
L
----
R
H
------
G
V
I
Y
--
D
F
I
M
K
L
R
R
N
-------
P
N
V
L
------
E
V
L-------
Q
R
K
S
Y
L
Y
V
R
D
A
V
E
A
T
L
A
A
W
K
K
F
E
E
M
D
A
---
P
F
L
A
L
N
V
G
N
V
D
A
V
R
V
L
D
I
A
Q
I
V
A
E
V
L
G
---------
L
R
P
E
I
R
L
V------------
G
D
V
K
Y
M
T
L
A
V
T
K
L
M
K
L
T
G
W
R
-
P
T
M
T
S
A
E
A
V
K
K
T
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
82.08
29%
-90
- C1 -
4WOK
2
?
A:
[12-325]
-
N
N
V
L
V
V
G
G
A
G
F
I
G
S
H
T
A
K
L
L
A
G
Q
G
--
Y
------
A
P
V
V
Y
D
--------------
N
L
S
-
T
G
H
-
Q
S
--
A
------
V
-
R
--
W
G
--
D
F
--
V
----
E
G
-----
D
I
L
D
Q
A
R
L
V
E
T
--
M
E
K
Y
A
---
P
--
V
A
V
I
H
F
A
A
S
A
Y
V
G
E
S
V
E
D
P
A
K
Y
Y
R
N
N
V
G
G
T
Q
S
L
L
D
A
C
R
L
T
-----
R
T
Q
N
V
I
F
S
S
S
-
C
-
A
-
T
Y
G
V
P
-
S
----------------------------------------
R
L
P
I
G
E
G
E
A
Q
N
P
I
N
P
Y
G
R
T
K
L
I
A
E
H
M
L
A
D
Y
A
V
A
-
Y
G
L
--
R
Y
V
A
L
R
Y
F
N
A
S
G
---
A
-------
D
I
----
D
G
E
L
G
E
K
H
D
P
E
T
--
H
L
I
P
R
A
M
M
A
A
A
G
R
L
D
V
L
E
V
Y
------
G
DDYETP
D
G
T
C
I
R
D
Y
I
H
V
T
D
L
A
R
A
H
V
L
A
V
E
H
L
K
-
E
A
G
---
G
N
L
A
V
N
L
G
T
G
R
G
T
S
I
R
E
I
V
Q
S
I
G
R
L
T
G
-----
R
S
--
V
P
V
A
M
---
R
A
-------
R
R
A
G
D
P
P
A
L
Y
A
D
P
A
L
A
A
E
K
L
G
F
H
-
T
V
Y
S
D
L
D
T
I
I
R
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
80.90
28%
-88
- C1 -
4LIS
6
?
A:
[6-335]
---
V
L
V
T
G
G
T
G
Y
I
G
S
F
T
T
L
A
L
L
E
A
G
--
Y
------
K
V
V
V
A
D
--------------
N
L
Y
N
S
S
A
E
A
L
N
-
R
------
I
E
L
--
I
S
--
G
K
--
K
A
E
F
A
Q
L
-----
D
V
T
D
E
A
A
F
D
K
V
--
F
E
--
A
H
PD
I
--
D
S
V
I
H
F
A
A
L
K
A
V
G
E
S
G
E
K
P
L
D
Y
Y
H
V
N
V
Y
G
T
I
C
L
L
R
S
M
V
R
H
-----
N
V
T
N
I
V
F
S
S
S
-
A
-
T
-
V
Y
G
D
A
T
R
F
P
DMIP
I
P
E
H
C
P
L
G
P
---------------
T
N
P
Y
G
N
T
K
F
A
I
E
L
A
I
T
D
V
I
N
A
Q
R
N
--
N
A
K
K
A
G
N
E
T
E
A
A
K
W
N
G
A
---------
L
L
R
Y
F
N
P
A
G
A
H
P
S
-------
G
I
M
G
E
D
P
Q
------
G
V
P
Y
--
N
L
L
P
L
L
A
Q
V
A
T
G
K
R
E
K
L
L
V
F
G
DDYAS
H
------
D
G
T
A
I
R
D
Y
I
H
I
L
D
L
A
D
G
H
L
K
A
L
N
Y
L
R
A
N
N
P
---
G
V
R
A
W
N
L
G
T
G
R
G
S
T
V
Y
E
M
I
R
A
F
S
K
A
V
G
-----
R
D
--
L
-
P
Y
E
V
--
A
P
-------
R
R
A
G
D
V
L
N
L
T
S
N
P
T
R
A
N
T
E
L
G
W
K
-
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
80.88
30%
-85
- C1 -
3VPS
2
?
A:
[8-301]
-
H
R
I
L
I
T
G
G
A
G
F
I
G
G
H
L
A
R
A
L
V
A
S
G
--
E
------
E
V
T
V
L
D
--------------
D
L
R
-
V
P
P
M
I
P
-----------
P
--
E
G
--
T
G
--
K
----
F
L
EK---
P
V
L
E
L
--
E
E
R
D
--
L
S
--
D
---
V
--
R
L
V
Y
H
L
A
S
H
K
S
V
P
R
S
F
K
Q
P
L
-
D
Y
L
D
N
V
D
S
G
R
H
L
L
A
L
C
T
S
V
-----
G
V
P
K
V
V
V
G
S
T
-
C
-
E
-
V
Y
G
Q
A
-
D
----------------------------------------
T
L
P
T
P
E
D
S
P
L
S
P
R
S
P
Y
A
A
S
K
V
G
L
E
M
V
A
G
A
H
Q
R
A
S
V
A
P
--
E
V
G
I
V
R
F
F
N
V
Y
G
---
P
-------
G
E
----
R
P
------
D
------
A
L
V
P
R
L
C
A
N
L
L
T
R
N
E
L
P
V
E
------
G
------
D
G
E
Q
R
R
D
F
T
Y
I
T
D
V
V
D
K
L
V
A
L
A
N
---
R
--
P
---
L
P
S
V
V
N
F
G
S
G
Q
S
L
S
V
N
D
V
I
R
I
L
Q
A
T
S
P
-----
A
A
---
E
V
A
R
K
---
Q
-------
P
R
P
N
E
I
T
E
F
R
A
D
T
A
L
Q
T
R
Q
I
G
E
R
S
G
G
I
G
I
E
E
G
I
R
L
T
L
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.24
27%
-88
- C1 -
1SB9
2
?
A:
[31-340]
----
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
T
L
L
K
L
D
--
Q
------
K
V
V
G
L
D
NFATGH
Q
R
N
L
D
E
V
R
S
L
V
-
S
E
K
Q
W
S
N
-
F
------
K
-
F
--
I
Q
--
G
---------------
D
I
R
N
L
D
D
C
N
N
A
--
C
A
--
G
---
V
--
D
Y
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
N
D
P
I
T
S
N
A
T
N
I
D
G
F
L
N
M
L
I
A
A
R
D
A
-----
K
V
Q
S
F
T
Y
A
A
S
-
S
-
S
-
T
Y
G
-----
D
----
H
P
---------------------------
G
L
P
K
V
-----
E
D
T
I
G
K
P
L
S
P
Y
A
V
T
K
Y
V
N
E
L
Y
A
D
V
F
S
R
C
-
Y
G
F
--
S
T
I
G
L
R
Y
F
N
V
F
G
---
R
-------
R
Q
----
D
P
------
N
G
A
Y
--
A
A
V
I
P
K
W
T
S
S
M
I
Q
G
D
D
V
Y
I
N
------
G
------
D
G
E
T
S
R
D
F
C
Y
I
E
N
T
V
Q
A
N
L
L
A
A
T
A
G
L
D
A
R
N
-----
Q
V
Y
N
I
A
V
G
G
R
T
S
L
N
Q
L
F
F
A
L
---
R
D
-----
G
L
--
A
E
N
G
V
S
--
Y
H
R
E
P
V
Y
R
D
F
R
E
G
D
V
R
H
S
L
A
D
I
S
K
A
A
K
L
L
G
Y
A
-
P
K
Y
D
V
S
A
G
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
80.13
26%
-92
- C1 -
3ICP
2
?
A:
[1-303]
-
M
R
I
V
V
T
G
G
A
G
F
I
G
S
H
L
V
D
K
L
V
E
L
G
--
Y
------
E
V
V
V
V
D
--------------
N
L
----
S
S
G
R
R
-
E
------
F
-
V
--
N
P
--
S
A
--
E
-----
L
-----
H
V
R
D
L
K
D
Y
S
-
W
--
G
A
--
G
---
I
KG
D
V
V
F
H
F
A
A
N
P
E
V
R
L
S
T
T
E
P
I
V
H
F
N
E
N
V
V
A
T
F
N
V
L
E
W
A
R
Q
T
-----
G
V
R
T
V
V
F
A
S
S
-
S
-
T
-
V
Y
G
D
A
-------------
D
V
I
P
T
P
----------------------------
E
E
E
P
Y
K
P
I
S
V
Y
G
A
A
K
A
A
G
E
V
M
C
A
T
Y
A
R
L
-
F
G
V
--
R
C
L
A
V
R
Y
A
N
V
V
G
---
P
-------
R
L
----
R
H
------
G
V
I
Y
--
D
F
I
M
K
L
R
R
N
-------
P
N
V
L
------
E
---------
Q
R
K
S
Y
L
Y
V
R
D
A
V
E
A
T
L
A
A
W
K
K
F
E
E
M
D
A
---
P
F
L
A
L
N
V
G
N
V
D
A
V
R
V
L
D
I
A
Q
I
V
A
E
V
L
G
---------
L
R
P
E
I
R
L
V------------
G
D
V
K
Y
M
T
L
A
V
T
K
L
M
K
L
T
G
W
R
-
P
T
M
T
S
A
E
A
V
K
K
T
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.11
27%
-90
- C1 -
4ZRM
3
?
A:
[4-301]
-
M
N
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
N
G
--
Y
------
G
V
I
V
V
D
--------------
N
L
--
S
S
G
K
V
E
N
-
L
------
N
-
R
--
N
A
--
L
F
--
Y
----
E
Q
-----
S
I
E
D
E
E
M
M
E
R
I
F
S
L
H
--
R
---
P
--
E
Y
V
F
H
L
A
A
Q
A
S
V
A
I
S
V
R
E
P
A
R
D
A
K
T
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
-----
G
V
K
K
F
I
F
S
S
T
-
G
G
A
-
I
Y
G
E
------------
N
V
K
V
F
P
T
P
-----------
E
T
E
I
P
-----------------
H
P
I
S
P
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
F
F
A
R
E
-
Y
G
L
--
K
Y
T
V
L
R
Y
A
N
V
Y
G
---
P
--------------
R
------
Q
D
P
Y
GE
A
G
V
V
A
I
F
T
E
R
M
L
R
G
E
E
V
H
I
F
------
G
------
D
G
E
Y
V
R
D
Y
V
Y
V
D
D
V
V
R
A
N
L
L
A
M
E
K
G
D
N
E
--------
V
F
N
I
G
T
G
R
G
T
T
V
N
Q
L
F
K
L
L
K
E
I
T
G
-----
Y
D
--
K
E
P
V
Y
K
--
P
P
--------
R
K
G
D
V
R
K
S
I
L
D
Y
T
K
A
K
E
K
L
G
W
E
-
P
K
V
S
L
E
E
G
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
79.79
27%
-88
- C1 -
1SB8
2
?
A:
[31-340]
----
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
T
L
L
K
L
D
--
Q
------
K
V
V
G
L
D
NFATGH
Q
R
N
L
D
E
V
R
S
L
V
-
S
E
K
Q
W
S
N
-
F
------
K
-
F
--
I
Q
--
G
---------------
D
I
R
N
L
D
D
C
N
N
A
--
C
A
--
G
---
V
--
D
Y
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
N
D
P
I
T
S
N
A
T
N
I
D
G
F
L
N
M
L
I
A
A
R
D
A
-----
K
V
Q
S
F
T
Y
A
A
S
-
S
-
S
-
T
Y
G
-----
D
----
H
P
---------------------------
G
L
P
K
V
-----
E
D
T
I
G
K
P
L
S
P
Y
A
V
T
K
Y
V
N
E
L
Y
A
D
V
F
S
R
C
-
Y
G
F
--
S
T
I
G
L
R
Y
F
N
V
F
G
---
R
-------
R
Q
----
D
P
------
N
G
A
Y
--
A
A
V
I
P
K
W
T
S
S
M
I
Q
G
D
D
V
Y
I
N
------
G
------
D
G
E
T
S
R
D
F
C
Y
I
E
N
T
V
Q
A
N
L
L
A
A
T
A
G
L
D
A
R
N
-----
Q
V
Y
N
I
A
V
G
G
R
T
S
L
N
Q
L
F
F
A
L
---
R
D
-----
G
L
--
A
E
N
G
V
S
--
Y
H
R
E
P
V
Y
R
D
F
R
E
G
D
V
R
H
S
L
A
D
I
S
K
A
A
K
L
L
G
Y
A
-
P
K
Y
D
V
S
A
G
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
79.67
26%
-90
- C1 -
3RUD
2
GNE_PLESH
A:
[29-339]
----
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
K
L
L
K
L
N
--
Q
------
V
V
I
G
L
D
--------------
N
F
--
S
T
G
H
Q
Y
N
-
L
D
E
V
K
T
L
V
-
S
--
T
E
--
Q
W
--
S
----
R
F
C
F
I
EG
D
I
R
D
L
T
T
C
E
Q
V
--
M
K
--
G
---
V
--
D
H
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
V
D
P
I
T
T
N
A
T
N
I
T
G
F
L
N
I
L
H
A
A
K
N
A
-----
Q
V
Q
S
F
T
Y
A
A
S
-
S
-
S
-
T
Y
G
-----
D
----
H
P
------
A
L
P
K
V
E
E
N
I
G
N
-----------------------
P
L
S
P
---
Y
A
V
T
K
Y
V
N
E
I
Y
A
Q
V
Y
A
R
T
-
Y
G
F
--
K
T
I
G
L
R
Y
F
N
V
F
G
---
R
-------
R
Q
----
D
P
------
N
G
A
Y
--
A
A
V
I
P
K
W
T
A
A
M
L
K
G
D
D
V
Y
I
N
------
G
------
D
G
E
T
S
R
D
F
C
Y
I
D
N
V
I
Q
M
N
I
L
S
A
L
A
K
D
S
A
K
D
---
N
I
--
Y
N
V
A
V
G
D
R
T
T
L
N
E
L
S
G
Y
I
Y
D
E
L
N
L
I
HHI-------
K
Y
R
---
E
-------
F
R
S
G
D
V
R
H
S
Q
A
D
V
T
K
A
I
D
L
L
K
Y
R
-
P
N
I
K
I
R
E
G
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
79.61
22%
-94
- C1 -
4EGB
19
?
A:
[25-333]
-
M
N
I
L
V
T
G
G
A
G
F
I
G
S
N
F
V
H
Y
M
L
Q
S
Y
ET
Y
------
K
I
I
N
F
D
--------------
A
L
T
-
Y
S
G
N
L
N
N
V
K
SI----
Q
-
D
--
H
P
N
Y
Y
F
--
V
----
K
G
-----
E
I
Q
N
G
E
L
L
E
H
V
--
I
K
E
R
D
---
V
--
Q
V
I
V
N
F
A
A
E
S
---------
I
P
F
Y
D
T
N
V
I
G
T
V
T
L
L
E
L
V
K
K
Y
-----
P
H
I
K
L
V
Q
V
S
T
-
D
-
E
-
V
Y
G
S
L
-
G
K
---------------------------------------
T
G
R
F
T
E
E
T
P
L
A
P
N
S
P
Y
S
S
S
K
A
S
A
D
M
I
A
L
A
Y
Y
K
T
-
Y
Q
L
--
P
V
I
V
T
R
C
S
N
N
Y
G
---
P
-------
Y
Q
----
Y
P
------
E
K
-----
L
I
P
L
M
V
T
-
N
A
L
E
G
K
K
L
P
L
Y
------
G
------
D
G
L
N
V
R
D
W
L
H
V
T
D
H
C
S
A
I
D
V
V
L
H
--
K
--
G
R
---
V
G
E
V
Y
N
I
G
G
N
N
E
K
T
N
V
E
V
V
E
Q
I
I
T
L
L
G
-----
K
T
--
K
K
D
I
E
Y
--
V
T
-------
D
--
G
H
D
R
R
Y
A
I
N
A
E
K
M
K
N
E
F
D
W
E
-
P
K
Y
T
F
E
Q
G
L
Q
E
T
V
Q
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.89
27%
-88
- C1 -
4ZRN
2
?
A:
[4-301]
-
M
N
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
N
G
--
Y
------
G
V
I
V
V
D
--------------
N
L
--
S
S
G
K
V
E
N
-
L
------
N
-
R
--
N
A
--
L
F
--
Y
----
E
Q
-----
S
I
E
D
E
E
M
M
E
R
I
F
S
L
H
--
R
---
P
--
E
Y
V
F
H
L
A
A
Q
A
S
V
A
I
S
V
R
E
P
A
R
D
A
K
T
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
-----
G
V
K
K
F
I
F
S
S
T
-
G
G
A
-
I
Y
G
E
------------
N
V
K
V
F
P
T
P
-----------
E
T
E
I
P
-----------------
H
P
I
S
P
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
F
F
A
R
E
-
Y
G
L
--
K
Y
T
V
L
R
Y
A
N
V
Y
G
---
P
--------------
R
------
Q
D
P
Y
GE
A
G
V
V
A
I
F
T
E
R
M
L
R
G
E
E
V
H
I
F
------
G
------
D
G
E
Y
V
R
D
Y
V
Y
V
D
D
V
V
R
A
N
L
L
A
M
E
K
G
D
N
E
--------
V
F
N
I
G
T
G
R
G
T
T
V
N
Q
L
F
K
L
L
K
E
I
T
G
-----
Y
D
--
K
E
P
V
Y
K
--
P
P
--------
R
K
G
D
V
R
K
S
I
L
D
Y
T
K
A
K
E
K
L
G
W
E
-
P
K
V
S
L
E
E
G
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------