@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0766c: (2016-04-25 )
MTVRVGDPELVLDPYDYDFHEDPYPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDPSSRTSEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDRARIRALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPANNLTSALLAAELDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR
Atome Classification :
(36 SA)
.........10........20........30......-----.---.--40-----.......---..50........----60........-70....-...-.80----......-..90........100.......110.......120.......130-..---.--......140.......150.......160..-------.....170----........180..-.-----....---------190......------.200..-.....210...-.-...--220.......230.......240.......250.......260.......270.-.......280...-...--.290........300.......310.......320...----....330....-...340...-....350.......360......--.370.....--..380......-.390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
V
RVGDP
E
L
V
LDPYDYDFHEDP
Y
P
Y
Y
R
R
LRDEAPLY-----R---N--E------ER
N
F
W
A
V
---
S
R
H
H
D
V
L
Q
G
FRD----STALSNAYGV-SLDPSS-R
T
S
-
E
A
Y
----
R
V
M
S
M
L
-AMDD
P
A
H
L
R
M
R
T
L
V
SKGF
T
P
R
R
I
R
EL
E
P
Q
V
L
E
L
A
R
I
H
LDSALQ---T
E
---
S
--
F
D
F
V
A
E
F
AGKL
P
M
D
V
I
S
E
L
IGVPDT
D
R
A
R
I
R
-------
A
L
A
D
A
V
L
-----HREDGVADVPP
P
A
-
M
-----
A
A
S
I
---------
E
L
M
R
Y
Y
A
D
L
------
I
A
E
F
R
R-RPA
N
N
L
T
S
A
L
L
-
A
-AEL--DGDRL
S
D
Q
E
I
M
A
F
L
F
L
M
V
IAGN
E
T
T
T
K
L
L
A
N
A
V
YWAAHH
P
G
Q
L
A
R
V
F
ADHSR-I-
P
M
W
V
E
E
T
LRYD
T
S
-
S
Q
I
--
L
A
-
R
T
V
AH
D
L
T
L
Y
DTTIPEG
E
V
L
L
L
LPGSANRDDRVFD----DPD
D
Y
R
I
G
R
E
I-G
C
K
L
V
SFGS-G
A
H
F
C
L
G
A
H
L
A
R
M
E
A
R
V
A
L
G
A
L
L
--
R
R
I
RNYEVD--DD
N
V
V
R
V
HSSN-VR
G
F
A
HL
P
I
S
V
QAR
3
PsiBlast_PDB
94.92
37%
-103
- C7 -
3A4Z
7
CPVDH_PSEAH
A:
[12-401]
------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
-----
K
---
L
--
A
LP----
D
G
P
V
W
L
L
---
T
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-
L
S
K
D
W
R
H
-
R
L
P
E
D
Q
-
R
A
D
M
P
A
T
----
P
T
P
M
M
I
-
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
---
D
G
---
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
-------
A
W
S
S
V
L
V
-------
D
D
S
P
A
D
D
K
N
A
A
-
M
-----
G
------------
K
L
H
G
Y
L
S
D
L
------
L
E
R
K
R
T
-
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
--
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
-
I
-
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
--
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
----
E
P
D
R
L
D
I
T
R
D
A
-
S
G
G
-
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
--
L
D
E
L
V
Y
R
R
S
T
L
-
V
R
G
L
S
R
M
P
V
T
M
G
P
R
25
PsiBlast_CBE
94.84
37%
-106
- C7 -
3A50
4
CPVDH_PSEAH
E:
[12-401]
------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
-----
K
---
L
--
A
LP----
D
G
P
V
W
L
L
---
T
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-
L
S
K
D
W
R
H
-
R
L
P
E
D
Q
-
R
A
D
M
P
A
T
----
P
T
P
M
M
I
-
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
---
D
G
---
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
-------
A
W
S
S
V
L
V
-------
D
D
S
P
A
D
D
K
N
A
A
-
M
-----
G
------------
K
L
H
G
Y
L
S
D
L
------
L
E
R
K
R
T
-
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
--
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
-
I
-
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
--
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
----
E
P
D
R
L
D
I
T
R
D
A
-
S
G
G
-
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
AD
R
P
E
L
A
L
A
V
G
--
L
D
E
L
V
Y
R
R
S
T
L
-
V
R
G
L
S
R
M
P
V
T
M
G
P
R
30
PsiBlast_CBE
94.55
37%
-103
- C7 -
3A4Z
5
CPVDH_PSEAH
D:
[12-401]
------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
-----
K
---
L
--
A
LP----
D
G
P
V
W
L
L
---
T
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-
L
S
K
D
W
R
H
-
R
L
P
E
D
Q
-
R
A
D
M
P
A
T
----
P
T
P
M
M
I
-
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
---
D
G
---
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
-------
A
W
S
S
V
L
V
-------
D
D
S
P
A
D
D
K
N
A
A
-
M
-----
G
------------
K
L
H
G
Y
L
S
D
L
------
L
E
R
K
R
T
-
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
--
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
-
I
-
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
--
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
----
E
P
D
R
L
D
I
T
R
D
A
-
S
G
G
-
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
AD
R
P
E
L
A
L
A
V
G
--
L
D
E
L
V
Y
R
R
S
T
L
-
V
R
G
L
S
R
M
P
V
T
M
G
P
R
29
PsiBlast_CBE
94.46
37%
-104
- C7 -
3A4Z
4
CPVDH_PSEAH
E:
[12-401]
------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
-----
K
---
L
--
A
LP----
D
G
P
V
W
L
L
---
T
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-
L
S
K
D
W
R
H
-
R
L
P
E
D
Q
-
R
A
D
M
P
A
T
----
P
T
P
M
M
I
-
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
---
D
G
---
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
-------
A
W
S
S
V
L
V
-------
D
D
S
P
A
D
D
K
N
A
A
-
M
-----
G
------------
K
L
H
G
Y
L
S
D
L
------
L
E
R
K
R
T
-
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
--
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
-
I
-
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
--
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
----
E
P
D
R
L
D
I
T
R
D
A
-
S
G
G
-
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
AD
R
P
E
L
A
L
A
V
G
--
L
D
E
L
V
Y
R
R
S
T
L
-
V
R
G
L
S
R
M
P
V
T
M
G
P
R
4
PsiBlast_PDB
94.41
37%
-104
- C7 -
3A50
8
CPVDH_PSEAH
A:
[12-401]
------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
-----
K
---
L
--
A
LP----
D
G
P
V
W
L
L
---
T
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-
L
S
K
D
W
R
H
-
R
L
P
E
D
Q
-
R
A
D
M
P
A
T
----
P
T
P
M
M
I
-
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
---
D
G
---
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
-------
A
W
S
S
V
L
V
-------
D
D
S
P
A
D
D
K
N
A
A
-
M
-----
G
------------
K
L
H
G
Y
L
S
D
L
------
L
E
R
K
R
T
-
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
--
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
-
I
-
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
--
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
----
E
P
D
R
L
D
I
T
R
D
A
-
S
G
G
-
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
--
L
D
E
L
V
Y
R
R
S
T
L
-
V
R
G
L
S
R
M
P
V
T
M
G
P
R
31
PsiBlast_CBE
94.37
37%
-105
- C7 -
3A4Z
4
CPVDH_PSEAH
C:
[12-401]
------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
-----
K
---
L
--
A
LP----
D
G
P
V
W
L
L
---
T
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-
L
S
K
D
W
R
H
-
R
L
P
E
D
Q
-
R
A
D
M
P
A
T
----
P
T
P
M
M
I
-
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
---
D
G
---
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
-------
A
W
S
S
V
L
V
-------
D
D
S
P
A
D
D
K
N
A
A
-
M
-----
G
------------
K
L
H
G
Y
L
S
D
L
------
L
E
R
K
R
T
-
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
--
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
-
I
-
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
--
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
----
E
P
D
R
L
D
I
T
R
D
A
-
S
G
G
-
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
AD
R
P
E
L
A
L
A
V
G
--
L
D
E
L
V
Y
R
R
S
T
L
-
V
R
G
L
S
R
M
P
V
T
M
G
P
R
21
PsiBlast_CBE
94.26
37%
-105
- C7 -
3A51
4
CPVDH_PSEAH
E:
[12-401]
------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
-----
K
---
L
--
A
LP----
D
G
P
V
W
L
L
---
T
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-
L
S
K
D
W
R
H
-
R
L
P
E
D
Q
-
R
A
D
M
P
A
T
----
P
T
P
M
M
I
-
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
---
D
G
---
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
-------
A
W
S
S
V
L
V
-------
D
D
S
P
A
D
D
K
N
A
A
-
M
-----
G
------------
K
L
H
G
Y
L
S
D
L
------
L
E
R
K
R
T
-
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
--
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
-
I
-
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
--
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
----
E
P
D
R
L
D
I
T
R
D
A
-
S
G
G
-
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
AD
R
P
E
L
A
L
A
V
G
--
L
D
E
L
V
Y
R
R
S
T
L
-
V
R
G
L
S
R
M
P
V
T
M
G
P
R
32
PsiBlast_CBE
93.72
37%
-102
- C7 -
3A4Z
2
CPVDH_PSEAH
B:
[12-401]
------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
-----
K
---
L
--
A
LP----
D
G
P
V
W
L
L
---
T
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-
L
S
K
D
W
R
H
-
R
L
P
E
D
Q
-
R
A
D
M
P
A
T
----
P
T
P
M
M
I
-
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
---
D
G
---
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
-------
A
W
S
S
V
L
V
-------
D
D
S
P
A
D
D
K
N
A
A
-
M
-----
G
------------
K
L
H
G
Y
L
S
D
L
------
L
E
R
K
R
T
-
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
--
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
-
I
-
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
--
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
----
E
P
D
R
L
D
I
T
R
D
A
-
S
G
G
-
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
AD
R
P
E
L
A
L
A
V
G
--
L
D
E
L
V
Y
R
R
S
T
L
-
V
R
G
L
S
R
M
P
V
T
M
G
P
R
123
HHSearch
93.64
32%
-99
- C7 -
2WM5
1
CP124_MYCTU
A:
[45-435]
---------------------
V
R
D
G
A
F
A
T
L
R
R
E
A
P
I
S
-----
F
---
W
--
P
T
IELVA
G
N
G
H
W
A
L
---
T
K
Y
D
D
V
F
Y
A
S
R
H
----
P
D
I
F
S
S
Y
P
N
I
-
T
I
N
D
Q
T
-
P
E
L
-
A
E
Y
-----
F
G
S
M
I
-
V
L
D
D
P
R
H
Q
R
L
R
S
I
V
S
R
A
F
T
P
K
V
V
A
R
I
E
A
A
V
R
D
R
A
H
R
L
V
S
S
M
I
A
N
N
P
D
R
---
Q
--
A
D
L
V
S
E
L
A
G
P
L
P
L
Q
I
I
C
D
M
M
G
I
P
K
A
D
H
Q
R
I
F
-------
H
W
T
N
V
I
L
-----
G
F
G
D
P
D
L
A
T
D
F
D
E
F
M
-----
Q
V
S
A
---------
D
I
G
A
Y
A
T
A
L
------
A
E
D
R
R
V
-
N
H
H
D
D
L
T
S
S
L
V
-
E
-
A
E
V
--
D
G
E
R
L
S
S
R
E
I
A
S
F
F
I
L
L
V
V
A
G
N
E
T
T
R
N
A
I
T
H
G
V
L
A
L
S
R
Y
P
E
Q
R
D
R
W
W
S
D
F
D
G
L
A
-
P
T
A
V
E
E
I
V
R
W
A
S
P
-
V
V
Y
--
M
R
-
R
T
L
T
Q
D
I
E
L
R
G
T
K
M
A
A
G
D
K
V
S
L
W
Y
C
S
A
N
R
D
E
S
K
F
A
----
D
P
W
T
F
D
L
A
R
N
P
--
N
P
H
L
G
F
G
G
G
G
A
H
F
C
L
G
A
N
L
A
R
R
E
I
R
V
A
F
D
E
L
R
--
R
Q
M
P
D
V
V
A
T
--
E
E
P
A
R
L
-
L
S
Q
F
-
I
H
G
I
K
T
L
P
V
T
W
S
--
57
PsiBlast_CBE
93.63
36%
-97
- C7 -
4BF4
3
PIKC_STRVZ
E:
[33-423]
-------
P
V
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
-----
R
VRT
P
--
E
------
G
N
E
V
W
L
V
VGY
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
-----
S
T
T
P
L
T
-
E
-
A
-
E
A
A
----
L
N
H
N
M
L
-
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
---
A
P
---
D
GR
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
-------
V
W
T
D
A
F
V
-----
F
P
D
D
-----
P
A
Q
A
-
Q
-----
T
A
M
A
---------
E
M
S
G
Y
L
S
R
L
------
I
D
S
K
R
G
-
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
--
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
-
L
-
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
--
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
----
D
P
H
R
F
D
I
R
R
D
T
-
A
G
H
L
-
A
F
G
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
--
E
R
C
P
D
L
A
L
D
VS
P
G
E
L
V
W
Y
P
N
P
M
-
I
R
G
L
K
A
L
P
I
-----
5
PsiBlast_PDB
93.63
37%
-106
- C7 -
3A51
8
CPVDH_PSEAH
A:
[12-401]
------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
-----
K
---
L
--
A
LP----
D
G
P
V
W
L
L
---
T
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-
L
S
K
D
W
R
H
-
R
L
P
E
D
Q
-
R
A
D
M
P
A
T
----
P
T
P
M
M
I
-
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
---
D
G
---
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
-------
A
W
S
S
V
L
V
-------
D
D
S
P
A
D
D
K
N
A
A
-
M
-----
G
------------
K
L
H
G
Y
L
S
D
L
------
L
E
R
K
R
T
-
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
--
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
-
I
-
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
--
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
----
E
P
D
R
L
D
I
T
R
D
A
-
S
G
G
-
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
--
L
D
E
L
V
Y
R
R
S
T
L
-
V
R
G
L
S
R
M
P
V
T
M
G
P
R
28
PsiBlast_CBE
93.50
37%
-102
- C7 -
3A50
2
CPVDH_PSEAH
B:
[12-401]
------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
-----
K
---
L
--
A
LP----
D
G
P
V
W
L
L
---
T
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-
L
S
K
D
W
R
H
-
R
L
P
E
D
Q
-
R
A
D
M
P
A
T
----
P
T
P
M
M
I
-
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
---
D
G
---
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
-------
A
W
S
S
V
L
V
-------
D
D
S
P
A
D
D
K
N
A
A
-
M
-----
G
------------
K
L
H
G
Y
L
S
D
L
------
L
E
R
K
R
T
-
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
--
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
-
I
-
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
--
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
----
E
P
D
R
L
D
I
T
R
D
A
-
S
G
G
-
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
AD
R
P
E
L
A
L
A
V
G
--
L
D
E
L
V
Y
R
R
S
T
L
-
V
R
G
L
S
R
M
P
V
T
M
G
P
R
27
PsiBlast_CBE
93.34
37%
-105
- C7 -
3A50
5
CPVDH_PSEAH
C:
[12-401]
------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
-----
K
---
L
--
A
LP----
D
G
P
V
W
L
L
---
T
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-
L
S
K
D
W
R
H
-
R
L
P
E
D
Q
-
R
A
D
M
P
A
T
----
P
T
P
M
M
I
-
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
---
D
G
---
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
-------
A
W
S
S
V
L
V
-------
D
D
S
P
A
D
D
K
N
A
A
-
M
-----
G
------------
K
L
H
G
Y
L
S
D
L
------
L
E
R
K
R
T
-
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
--
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
-
I
-
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
--
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
----
E
P
D
R
L
D
I
T
R
D
A
-
S
G
G
-
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
AD
R
P
E
L
A
L
A
V
G
--
L
D
E
L
V
Y
R
R
S
T
L
-
V
R
G
L
S
R
M
P
V
T
M
G
P
R
1
PsiBlast_PDB
93.30
37%
-97
- C7 -
3A4G
2
CPVDH_PSEAH
A:
[12-401]
------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
-----
K
---
L
AL
P
------
D
G
P
V
W
L
L
---
T
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-
L
S
K
D
W
R
H
-
T
L
P
E
D
Q
-
R
A
D
M
P
A
T
----
P
T
P
M
M
I
-
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
---
D
G
---
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
-------
A
W
S
S
V
L
V
-------
D
D
S
P
A
D
D
K
N
A
A
-
M
-----
G
------------
K
L
H
G
Y
L
S
D
L
------
L
E
R
K
R
T
-
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
E
--
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
-
I
-
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
--
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
----
E
P
D
R
L
D
I
T
R
D
A
-
S
G
G
-
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
--
L
D
E
L
V
Y
R
E
S
T
L
-
V
R
G
L
S
R
M
P
V
T
M
G
P
R
23
PsiBlast_CBE
93.19
37%
-105
- C7 -
3A51
5
CPVDH_PSEAH
C:
[12-401]
------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
-----
K
---
L
--
A
LP----
D
G
P
V
W
L
L
---
T
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-
L
S
K
D
W
R
H
-
R
L
P
E
D
Q
-
R
A
D
M
P
A
T
----
P
T
P
M
M
I
-
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
---
D
G
---
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
-------
A
W
S
S
V
L
V
-------
D
D
S
P
A
D
D
K
N
A
A
-
M
-----
G
------------
K
L
H
G
Y
L
S
D
L
------
L
E
R
K
R
T
-
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
--
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
-
I
-
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
--
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
----
E
P
D
R
L
D
I
T
R
D
A
-
S
G
G
-
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
AD
R
P
E
L
A
L
A
V
G
--
L
D
E
L
V
Y
R
R
S
T
L
-
V
R
G
L
S
R
M
P
V
T
M
G
P
R
26
PsiBlast_CBE
93.17
37%
-104
- C7 -
3A50
6
CPVDH_PSEAH
D:
[12-401]
------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
-----
K
---
L
--
A
LP----
D
G
P
V
W
L
L
---
T
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-
L
S
K
D
W
R
H
-
R
L
P
E
D
Q
-
R
A
D
M
P
A
T
----
P
T
P
M
M
I
-
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
---
D
G
---
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
-------
A
W
S
S
V
L
V
-------
D
D
S
P
A
D
D
K
N
A
A
-
M
-----
G
------------
K
L
H
G
Y
L
S
D
L
------
L
E
R
K
R
T
-
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
--
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
-
I
-
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
--
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
----
E
P
D
R
L
D
I
T
R
D
A
-
S
G
G
-
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
AD
R
P
E
L
A
L
A
V
G
--
L
D
E
L
V
Y
R
R
S
T
L
-
V
R
G
L
S
R
M
P
V
T
M
G
P
R
22
PsiBlast_CBE
93.10
37%
-104
- C7 -
3A51
6
CPVDH_PSEAH
D:
[12-401]
------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
-----
K
---
L
--
A
LP----
D
G
P
V
W
L
L
---
T
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-
L
S
K
D
W
R
H
-
R
L
P
E
D
Q
-
R
A
D
M
P
A
T
----
P
T
P
M
M
I
-
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
---
D
G
---
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
-------
A
W
S
S
V
L
V
-------
D
D
S
P
A
D
D
K
N
A
A
-
M
-----
G
------------
K
L
H
G
Y
L
S
D
L
------
L
E
R
K
R
T
-
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
--
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
-
I
-
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
--
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
----
E
P
D
R
L
D
I
T
R
D
A
-
S
G
G
-
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
AD
R
P
E
L
A
L
A
V
G
--
L
D
E
L
V
Y
R
R
S
T
L
-
V
R
G
L
S
R
M
P
V
T
M
G
P
R
6
PsiBlast_PDB
92.88
37%
-101
- C7 -
3VRM
2
CPVDH_PSEAH
A:
[12-401]
------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
-----
K
---
L
--
A
LP----
D
G
P
V
W
L
L
---
T
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-
L
S
K
D
W
R
H
-
T
L
P
E
D
Q
-
R
A
D
M
P
A
T
----
P
T
P
M
M
I
-
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
A
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
---
D
G
---
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
-------
A
W
S
S
V
L
V
-------
D
D
S
P
A
D
D
K
N
A
A
-
M
-----
G
------------
K
L
H
G
Y
L
S
D
L
------
L
E
R
K
R
T
-
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
E
--
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
-
I
-
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
--
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
----
E
P
D
R
L
D
I
T
R
D
A
-
S
G
G
-
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
--
L
D
E
L
V
Y
R
E
S
T
L
-
V
R
G
L
S
R
M
P
V
T
M
G
P
R
93
PsiBlast_CBE
92.83
34%
-108
- C7 -
3ZKP
2
ERYK_SACEN
A:
[33-401]
-------------------------
W
L
G
T
M
R
E
K
Q
P
V
W
-----
Q
---
D
--
R
-------
Y
G
V
W
H
V
---
F
R
H
A
D
V
Q
T
V
L
R
D
----
T
A
T
F
S
S
D
P
T
R
-
V
I
E
G
A
S
-
P
T
P
-
G
A
I
----
H
------
E
I
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
V
T
R
S
L
L
A
D
A
-----
G
E
---
S
--
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
M
D
H
E
Q
F
G
-------
D
W
S
G
A
L
V
-----
D
I
Q
--
M
D
D
P
T
D
P
A
-
L
-----
A
E
R
I
A
D
V
L
N
----
P
L
T
A
Y
L
K
A
R
------
C
A
E
R
R
A
-
D
P
G
D
D
L
I
S
R
L
V
-
L
-
A
E
V
--
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
R
T
L
D
E
H
P
A
H
W
D
A
A
A
E
D
P
G
R
-
I
-
P
A
I
V
E
E
V
L
R
Y
R
P
P
-
F
P
Q
--
M
Q
-
R
T
T
T
K
A
T
E
V
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
----
D
P
D
R
F
D
P
S
R
K
S
G
G
A
A
Q
L
S
F
G
H
-
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
--
A
R
F
G
R
L
T
V
D
R-
D
D
E
R
L
R
H
F
E
Q
I
-
V
L
G
T
R
H
L
P
V
-----
59
PsiBlast_CBE
92.77
36%
-97
- C7 -
4BF4
2
PIKC_STRVZ
C:
[33-423]
-------
P
V
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
-----
R
VRT
P
--
E
------
G
N
E
V
W
L
V
VGY
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
-----
S
T
T
P
L
T
-
E
-
A
-
E
A
A
----
L
N
H
N
M
L
-
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
---
A
P
---
D
GR
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
-------
V
W
T
D
A
F
V
-----
F
P
D
D
-----
P
A
Q
A
-
Q
-----
T
A
M
A
---------
E
M
S
G
Y
L
S
R
L
------
I
D
S
K
R
G
-
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
--
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
-
L
-
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
--
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
----
D
P
H
R
F
D
I
R
R
D
T
-
A
G
H
L
-
A
F
G
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
--
E
R
C
P
D
L
A
L
D
VS
P
G
E
L
V
W
Y
P
N
P
M
-
I
R
G
L
K
A
L
P
I
-----
35
PsiBlast_CBE
92.24
36%
-102
- C7 -
3R9B
11
?
B:
[18-414]
---------
L
L
L
Q
L
L
D
P
A
T
R
A
D
P
Y
P
I
Y
D
R
I
R
R
G
G
P
L
A
-----
L
---
P
--
E
------
A
-
N
L
A
V
F
---
S
S
F
S
D
C
D
D
V
L
R
H
----
P
S
S
C
S
D
R
T
K
S
-
T
I
F
Q
R
Q
-
L
A
----------
P
A
S
F
L
-
F
L
D
P
P
D
H
T
R
L
R
G
L
V
S
K
A
F
A
P
R
V
I
K
R
L
E
P
E
I
T
A
L
V
D
Q
L
L
D
-
A
V
D
---
G
P
---
E
--
F
N
L
I
D
N
L
A
Y
P
L
P
V
A
V
I
C
R
L
L
G
V
P
I
E
D
E
P
K
F
S
RASALLA
A
A
L
D
P
F
L
-----
A
L
T
G
E
T
S
D
L
F
D
E
Q
-
M
-----
K
A
G
M
---------
W
L
R
D
Y
L
R
A
L
------
I
D
E
R
R
R
-
T
P
G
E
D
L
M
S
G
L
V
-
A
-
V
E
E
--
S
G
D
Q
L
T
E
D
E
I
I
A
T
C
N
L
L
L
I
A
G
H
E
T
T
V
N
L
I
A
N
A
A
L
A
M
L
R
T
P
G
Q
W
A
A
L
A
A
D
G
S
R
-
A
-
S
A
V
I
E
E
T
M
R
Y
D
P
P
-
V
Q
L
--
V
S
-
R
Y
A
G
D
D
L
T
I
G
T
H
T
V
P
K
G
D
T
M
L
L
L
L
A
A
A
H
R
D
P
T
I
V
G
----
A
P
D
R
F
D
P
D
R
A
--
Q
I
R
H
L
G
F
G
K
-
G
A
H
F
C
L
G
A
P
L
A
R
L
E
A
T
V
A
L
P
A
L
A
--
A
R
F
P
E
A
R
L
S
--
G
E
P
E
Y
K
-
R
N
L
T
-
L
R
G
M
S
T
L
S
I
A
V
---
34
PsiBlast_CBE
92.24
36%
-102
- C7 -
3R9B
5
?
C:
[18-414]
---------
L
L
L
Q
L
L
D
P
A
T
R
A
D
P
Y
P
I
Y
D
R
I
R
R
G
G
P
L
A
-----
L
---
P
--
E
------
A
-
N
L
A
V
F
---
S
S
F
S
D
C
D
D
V
L
R
H
----
P
S
S
C
S
D
R
T
K
S
-
T
I
F
Q
R
Q
-
L
A
----------
P
A
S
F
L
-
F
L
D
P
P
D
H
T
R
L
R
G
L
V
S
K
A
F
A
P
R
V
I
K
R
L
E
P
E
I
T
A
L
V
D
Q
L
L
D
-
A
V
D
---
G
P
---
E
--
F
N
L
I
D
N
L
A
Y
P
L
P
V
A
V
I
C
R
L
L
G
V
P
I
E
D
E
P
K
F
S
RASALLA
A
A
L
D
P
F
L
-----
A
L
T
G
E
T
S
D
L
F
D
E
Q
-
M
-----
K
A
G
M
---------
W
L
R
D
Y
L
R
A
L
------
I
D
E
R
R
R
-
T
P
G
E
D
L
M
S
G
L
V
-
A
-
V
E
E
--
S
G
D
Q
L
T
E
D
E
I
I
A
T
C
N
L
L
L
I
A
G
H
E
T
T
V
N
L
I
A
N
A
A
L
A
M
L
R
T
P
G
Q
W
A
A
L
A
A
D
G
S
R
-
A
-
S
A
V
I
E
E
T
M
R
Y
D
P
P
-
V
Q
L
--
V
S
-
R
Y
A
G
D
D
L
T
I
G
T
H
T
V
P
K
G
D
T
M
L
L
L
L
A
A
A
H
R
D
P
T
I
V
G
----
A
P
D
R
F
D
P
D
R
A
--
Q
I
R
H
L
G
F
G
K
-
G
A
H
F
C
L
G
A
P
L
A
R
L
E
A
T
V
A
L
P
A
L
A
--
A
R
F
P
E
A
R
L
S
--
G
E
P
E
Y
K
-
R
N
L
T
-
L
R
G
M
S
T
L
S
I
A
V
---
126
HHSearch
92.01
34%
-90
- C7 -
3WVS
8
?
A:
[10-401]
-------
P
E
S
L
S
Y
P
F
G
P
D
E
G
L
A
L
S
E
S
Y
T
R
A
R
D
T
D
G
L
I
-----
R
---
V
--
K
L
PY---
G
E
P
A
W
L
A
---
T
R
Y
E
D
A
R
L
V
L
G
D
----
A
-
R
F
S
R
A
L
S
E
E
H
D
P
P
R
A
-
R
K
--
F
N
A
----
Q
A
K
S
M
F
-
N
M
D
A
P
D
H
T
R
L
R
R
L
I
S
K
A
F
T
I
R
R
V
E
E
L
R
P
K
V
H
D
L
A
H
R
L
I
D
D
M
L
A
K
--
G
E
---
P
--
A
D
L
V
A
D
Y
A
L
P
I
P
T
T
V
I
C
E
L
L
G
V
P
F
E
D
R
E
K
F
G
-------
R
W
T
D
A
I
L
-----
S
T
S
T
L
---
N
P
E
E
G
-
R
-----
V
K
R
M
---------
E
L
V
G
Y
I
G
G
I
------
I
A
A
R
R
A
-
Q
P
A
D
D
L
I
S
G
M
I
-
E
-
A
R
D
--
V
Q
D
K
L
T
E
Q
E
L
L
D
H
C
I
G
L
L
I
A
G
H
E
T
T
A
S
Q
I
P
S
F
V
Y
A
L
L
D
Q
P
Q
H
W
K
R
L
L
D
D
P
E
L
-
I
-
P
S
A
V
E
E
L
F
R
F
V
P
L
-
G
S
G
SA
A
P
-
R
Y
A
R
E
D
I
E
V
G
G
T
L
V
R
A
G
E
P
V
L
V
A
L
G
A
A
N
R
D
G
L
R
F
E
----
D
P
E
E
I
K
L
D
R
P
S
--
N
H
H
I
G
F
G
H
-
G
I
H
H
C
L
G
A
P
L
A
R
L
E
L
Q
E
A
L
R
A
L
L
--
E
R
L
P
T
L
K
V
A
---
G
D
I
A
W
K
S
E
M
M
-
V
R
G
P
R
S
M
P
V
G
W
---
2
PsiBlast_PDB
91.94
37%
-95
- C7 -
3A4H
2
CPVDH_PSEAH
A:
[12-401]
------------
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
-----
K
---
L
AL
P
------
D
G
P
V
W
L
L
---
T
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-
L
S
K
D
W
R
H
-
T
L
P
E
D
Q
-
R
A
D
M
P
A
T
----
P
T
P
M
M
I
-
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
---
D
G
---
P
--
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
-------
A
W
S
S
V
L
V
-------
D
D
S
P
A
D
D
K
N
A
A
-
M
-----
G
------------
K
L
H
G
Y
L
S
D
L
------
L
E
R
K
R
T
-
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
E
--
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
-
I
-
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
--
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
----
E
P
D
R
L
D
I
T
R
D
A
-
S
G
G
-
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
--
L
D
E
L
V
Y
R
E
S
T
L
-
V
R
G
L
S
R
M
P
V
T
M
G
P
R
89
PsiBlast_CBE
91.78
35%
-108
- C7 -
2WIO
1
ERYK_SACEN
A:
[53-421]
-------------------------
W
L
G
T
M
R
E
K
Q
P
V
W
-----
Q
---
D
--
R
-------
Y
G
V
W
H
V
---
F
R
H
A
D
V
Q
T
V
L
R
D
----
T
A
T
F
S
S
-------
D
P
T
R
-
V
I
E
-
G
A
S
----
P
T
P
G
M
I
H
E
I
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
V
T
R
S
L
L
A
D
A
-----
G
E
---
S
--
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
M
D
H
E
Q
F
G
-------
D
W
S
G
A
L
V
-----
D
I
Q
--
M
D
D
P
T
D
P
A
-
L
-----
A
E
R
I
A
D
V
L
N
----
P
L
T
A
Y
L
K
A
R
------
C
A
E
R
R
A
-
D
P
G
D
D
L
I
S
R
L
V
-
L
-
A
E
V
--
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
R
T
L
D
E
H
P
A
H
W
D
A
A
A
E
D
P
G
R
-
I
-
P
A
I
V
E
E
V
L
R
Y
R
P
P
-
F
P
Q
--
M
Q
-
R
T
T
T
K
A
T
E
V
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
----
D
P
D
R
F
D
P
S
R
K
S
G
G
A
A
Q
L
S
F
G
H
-
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
--
A
R
F
G
R
L
T
V
D
R-
D
D
E
R
L
R
H
F
E
Q
I
-
V
L
G
T
R
H
L
P
V
-----
9
PsiBlast_PDB
91.32
36%
-102
- C7 -
3R9C
10
?
A:
[18-414]
---------
L
L
L
Q
L
L
D
P
A
T
R
A
D
P
Y
P
I
Y
D
R
I
R
R
G
G
P
L
A
-----
L
---
P
--
E
------
A
-
N
L
A
V
F
---
S
S
F
S
D
C
D
D
V
L
R
H
----
P
S
S
C
S
D
R
T
K
S
-
T
I
F
Q
R
Q
-
L
A
A
-
E
T
Q
PRPQ
G
P
A
S
F
L
-
F
L
D
P
P
D
H
T
R
L
R
G
L
V
S
K
A
F
A
P
R
V
I
K
R
L
E
P
E
I
T
A
L
V
D
Q
L
L
D
-
A
V
D
---
G
P
---
E
--
F
N
L
I
D
N
L
A
Y
P
L
P
V
A
V
I
C
R
L
L
G
V
P
I
E
D
E
P
K
F
S
R
A
S
A
L
L
A
A
A
L
D
P
F
L
-----
A
L
T
G
E
T
S
D
L
F
D
E
Q
-
M
-----
K
A
G
M
---------
W
L
R
D
Y
L
R
A
L
------
I
D
E
R
R
R
-
T
P
G
E
D
L
M
S
G
L
V
-
A
-
V
E
E
--
S
G
D
Q
L
T
E
D
E
I
I
A
T
C
N
L
L
L
I
A
G
H
E
T
T
V
N
L
I
A
N
A
A
L
A
M
L
R
T
P
G
Q
W
A
A
L
A
A
D
G
S
R
-
A
-
S
A
V
I
E
E
T
M
R
Y
D
P
P
-
V
Q
L
--
V
S
-
R
Y
A
G
D
D
L
T
I
G
T
H
T
V
P
K
G
D
T
M
L
L
L
L
A
A
A
H
R
D
P
T
I
V
G
----
A
P
D
R
F
D
P
D
R
A
--
Q
I
R
H
L
G
F
G
K
-
G
A
H
F
C
L
G
A
P
L
A
R
L
E
A
T
V
A
L
P
A
L
A
--
A
R
F
P
E
A
R
L
S
--
G
E
P
E
Y
K
-
R
N
L
T
-
L
R
G
M
S
T
L
S
I
A
V
---
10
PsiBlast_PDB
91.04
36%
-103
- C7 -
3R9B
9
?
A:
[18-414]
---------
L
L
L
Q
L
L
D
P
A
T
R
A
D
P
Y
P
I
Y
D
R
I
R
R
G
G
P
L
A
-----
L
---
P
--
E
------
A
-
N
L
A
V
F
---
S
S
F
S
D
C
D
D
V
L
R
H
----
P
S
S
C
S
D
R
T
K
S
-
T
I
F
Q
R
Q
-
L
A
----------
P
A
S
F
L
-
F
L
D
P
P
D
H
T
R
L
R
G
L
V
S
K
A
F
A
P
R
V
I
K
R
L
E
P
E
I
T
A
L
V
D
Q
L
L
D
-
A
V
D
---
G
P
---
E
--
F
N
L
I
D
N
L
A
Y
P
L
P
V
A
V
I
C
R
L
L
G
V
P
I
E
D
E
P
K
F
S
R
A
S
A
L
L
A
A
A
L
D
P
F
L
-----
A
L
T
G
E
T
S
D
L
F
D
E
Q
-
M
-----
K
A
G
M
---------
W
L
R
D
Y
L
R
A
L
------
I
D
E
R
R
R
-
T
P
G
E
D
L
M
S
G
L
V
-
A
-
V
E
E
--
S
G
D
Q
L
T
E
D
E
I
I
A
T
C
N
L
L
L
I
A
G
H
E
T
T
V
N
L
I
A
N
A
A
L
A
M
L
R
T
P
G
Q
W
A
A
L
A
A
D
G
S
R
-
A
-
S
A
V
I
E
E
T
M
R
Y
D
P
P
-
V
Q
L
--
V
S
-
R
Y
A
G
D
D
L
T
I
G
T
H
T
V
P
K
G
D
T
M
L
L
L
L
A
A
A
H
R
D
P
T
I
V
G
----
A
P
D
R
F
D
P
D
R
A
--
Q
I
R
H
L
G
F
G
K
-
G
A
H
F
C
L
G
A
P
L
A
R
L
E
A
T
V
A
L
P
A
L
A
--
A
R
F
P
E
A
R
L
S
--
G
E
P
E
Y
K
-
R
N
L
T
-
L
R
G
M
S
T
L
S
I
A
V
---
7
PsiBlast_PDB
90.85
35%
-94
- C7 -
2UVN
8
CP130_MYCTU
A:
[26-412]
---------------------
N
P
W
P
M
Y
R
A
L
R
D
H
D
P
V
H
H
V
V
PP
Q
---
R
--
P
------
E
Y
D
Y
Y
V
L
---
S
R
H
A
D
V
W
S
A
A
R
D
----
H
Q
T
F
S
S
A
Q
G
L
-
T
V
N
Y
G
E
L
E
M
I
-
G
L
H
----
D
T
P
P
M
V
-
M
Q
D
P
P
V
H
T
E
F
R
K
L
V
S
R
G
F
T
P
R
Q
V
E
T
V
E
P
T
V
R
K
F
V
V
E
R
L
E
K
L
R
A
---
N
G
---
G
--
G
D
I
V
T
E
L
F
K
P
L
P
S
M
V
V
A
H
Y
L
G
V
P
E
E
D
W
T
Q
F
D
-------
G
W
T
Q
A
I
V
------
A
A
N
---
G
A
T
T
G
A
-
L
-----
D
A
V
G
---------
S
M
M
A
Y
F
T
G
L
------
I
E
R
R
R
T
-
E
P
A
D
D
A
I
S
H
L
V
-
A
-
A
G
V
GA
D
G
D
T
A
G
T
L
S
I
L
A
F
T
F
T
M
V
T
G
G
N
D
T
V
T
G
M
L
G
G
S
M
P
L
L
H
R
R
P
D
Q
R
R
L
L
L
D
D
P
E
G
-
I
-
P
D
A
V
E
E
L
L
R
L
T
S
P
-
V
Q
G
--
L
A
-
R
T
T
T
R
D
V
T
I
G
D
T
T
I
P
A
G
R
R
V
L
L
L
Y
G
S
A
N
R
D
E
R
Q
Y
G
PDAA
E
L
D
V
T
R
C
P
R
N
I
-----
L
T
F
S
H
-
G
A
H
H
C
L
G
A
A
A
A
R
M
Q
C
R
V
A
L
T
E
L
L
--
A
R
C
P
D
F
E
V
A
--
E
S
R
I
V
W
S
G
G
S
Y
-
V
R
R
P
L
S
V
P
F
R
V
T
S
-
18
PsiBlast_PDB
90.79
36%
-96
- C7 -
3ZPI
13
PIKC_STRVZ
A:
[33-423]
-------
P
V
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
-----
R
V
R
T
P
--
E
------
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
-----
S
T
T
P
L
T
-
E
-
A
-
E
A
A
----
L
N
H
N
M
L
-
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
---
A
P
---
D
GR
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
-------
V
W
T
D
A
F
V
-----
F
P
D
D
-----
P
A
Q
A
-
Q
-----
T
A
M
A
---------
E
M
S
G
Y
L
S
R
L
------
I
D
S
K
R
G
-
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
--
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
-
L
-
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
--
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
----
D
P
H
R
F
D
I
R
R
D
T
-
A
G
H
L
-
A
F
G
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
--
E
R
C
P
D
L
A
L
D
VS
P
G
E
L
V
W
Y
P
N
P
M
-
I
R
G
L
K
A
L
P
I
-----
74
PsiBlast_CBE
90.17
36%
-92
- C7 -
2CA0
2
PIKC_STRVZ
B:
[34-423]
--------
V
L
D
L
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
-----
R
VRT
P
--
E
------
G
D
E
V
W
L
V
VGY
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
-----
S
T
T
P
L
T
-
E
-
A
-
E
A
A
----
L
N
H
N
M
L
-
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
---
A
P
---
D
GR
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
-------
V
W
T
D
A
F
V
-----
F
P
D
D
-----
P
A
Q
A
-
Q
-----
T
A
M
A
---------
E
M
S
G
Y
L
S
R
L
------
I
D
S
K
R
G
-
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
--
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
-
L
-
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
--
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
----
D
P
H
R
F
D
I
R
R
D
T
-
A
G
H
L
-
A
F
G
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
--
E
R
C
P
D
L
A
L
D
VS
P
G
E
L
V
W
Y
P
N
P
M
-
I
R
G
L
K
A
L
P
I
-----
85
PsiBlast_CBE
89.72
35%
-107
- C7 -
2XFH
4
ERYK_SACEN
A:
[33-401]
-------------------------
W
L
G
T
M
R
E
K
Q
P
V
W
-----
Q
---
D
--
R
-------
Y
G
V
W
H
V
---
F
R
H
A
D
V
Q
T
V
L
R
D
----
T
A
T
F
S
S
-------
D
P
T
R
-
V
I
E
-
G
A
S
----
P
T
P
G
M
I
H
E
I
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
V
T
R
S
L
L
A
D
A
-----
G
E
---
S
--
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
M
D
H
E
Q
F
G
-------
D
W
S
G
A
L
V
-----
D
I
Q
--
M
D
D
P
T
D
P
A
-
L
-----
A
E
R
I
A
D
V
L
N
----
P
L
T
A
Y
L
K
A
R
------
C
A
E
R
R
A
-
D
P
G
D
D
L
I
S
R
L
V
-
L
-
A
E
V
--
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
R
T
L
D
E
H
P
A
H
W
D
A
A
A
E
D
P
G
R
-
I
-
P
A
I
V
E
E
V
L
R
Y
R
P
P
-
F
P
Q
--
M
Q
-
R
T
T
T
K
A
T
E
V
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
----
D
P
D
R
F
D
P
S
R
K
S
G
G
A
A
Q
L
S
F
G
H
-
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
--
A
R
F
G
R
L
T
V
D
R-
D
D
E
R
L
R
H
F
E
Q
I
-
V
L
G
T
R
H
L
P
V
-----
96
PsiBlast_CBE
89.57
31%
-111
- C7 -
4TRI
3
?
A:
[27-391]
--------------------------
Y
R
W
M
R
A
N
E
P
V
F
-----
R
---
D
--
R
------
N
-
G
L
A
A
A
---
T
T
Y
Q
A
V
L
D
A
E
R
N
----
P
E
L
F
S
S
T
G
G
I
-
R
P
D
Q
P
G
-------------
M
P
Y
M
I
-
D
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
L
C
D
T
L
I
D
A
V
C
E
---
R
G
---
E
--
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
-------
K
W
S
D
D
L
V
C
G
LSS
H
V
D
E
A
A
I
Q
K
L
M
D
T
-
F
-----
A
A
Y
T
---------
E
---
F
T
K
D
V
------
I
T
K
R
R
A
-
E
P
T
D
D
L
F
S
V
L
V
-
N
-
S
E
V
--
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
V
D
L
-
L
-
P
G
A
I
E
E
M
L
R
W
T
S
P
-
V
K
N
--
M
C
-
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
----
D
P
D
N
F
R
I
D
R
N
P
-
N
S
H
-
V
A
F
G
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
--
R
R
L
P
D
L
R
L
A
--
D
D
A
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
-----
95
PsiBlast_CBE
88.30
31%
-112
- C7 -
4TRI
3
?
B:
[27-391]
--------------------------
Y
R
W
M
R
A
N
E
P
V
F
-----
R
---
D
--
R
------
N
-
G
L
A
A
A
---
T
T
Y
Q
A
V
L
D
A
E
R
N
----
P
E
L
F
S
S
T
G
G
I
-
R
P
D
Q
P
G
-------------
M
P
Y
M
I
-
D
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
L
C
D
T
L
I
D
A
V
C
E
---
R
G
---
E
--
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
-------
K
W
S
D
D
L
V
C
G
LSS
H
V
D
E
A
A
I
Q
K
L
M
D
T
-
F
-----
A
A
Y
T
---------
E
---
F
T
K
D
V
------
I
T
K
R
R
A
-
E
P
T
D
D
L
F
S
V
L
V
-
N
-
S
E
V
--
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
V
D
L
-
L
-
P
G
A
I
E
E
M
L
R
W
T
S
P
-
V
K
N
--
M
C
-
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
----
D
P
D
N
F
R
I
D
R
N
P
-
N
S
H
-
V
A
F
G
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
--
R
R
L
P
D
L
R
L
A
--
D
D
A
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
-----
83
PsiBlast_CBE
86.18
33%
-104
- C7 -
4GGV
1
?
A:
[29-388]
----------------
W
N
I
H
P
D
-
H
L
W
L
R
G
Q
R
P
E
S
P
V
V
-----
F
---
D
--
E
------
T
Q
G
V
W
N
V
---
Y
G
Y
P
E
A
M
D
I
L
N
D
HDTF
T
S
D
L
A
H
L
L
P
V
-
S
V
D
A
P
L
-
L
E
G
-
D
----------
M
S
-
Q
M
D
P
P
R
H
R
K
Y
R
Q
L
V
S
R
A
F
T
P
R
L
V
A
D
M
E
T
R
V
A
D
I
T
R
E
L
L
D
A
V
D
G
---
K
P
---
E
--
I
E
I
A
A
D
L
A
Y
P
L
P
V
I
V
I
A
E
L
L
G
V
P
A
G
D
R
D
L
F
K
-------
K
W
A
D
D
I
I
-----
E
G
F
S
G
F
S
F
L
D
T
S
G
-
Q
-----
G
E
Q
D
V
R
D
A
T
E
R
L
R
P
L
L
D
Y
M
A
G
H
------
V
T
E
R
R
R
-
T
P
R
E
D
L
L
T
H
L
V
-
Q
-
A
E
V
--
D
G
E
R
L
T
D
N
E
I
V
N
V
A
N
I
L
L
V
T
G
H
I
T
T
T
M
T
L
G
N
T
V
L
C
L
D
A
D
P
E
V
A
A
K
V
R
A
D
R
S
L
-
V
-
P
G
A
I
E
E
A
L
R
V
L
S
P
-
S
A
A
--
L
A
-
R
G
T
S
R
E
V
E
V
A
G
T
V
I
P
K
D
Q
I
V
M
L
W
L
G
A
G
N
R
D
P
R
Q
F
T
----
D
P
E
V
Y
D
P
T
R
D
P
-
N
P
H
F
-
G
F
G
R
-
G
I
H
F
C
L
G
A
P
L
A
R
L
E
G
R
V
A
L
N
A
L
F
--
D
R
F
----------------------------------
81
PsiBlast_CBE
85.78
33%
-108
- C7 -
2WM5
1
CP124_MYCTU
A:
[77-433]
------------------------------------------------------------
W
A
L
---
T
K
Y
D
D
V
F
Y
A
S
R
H
----
P
D
I
F
S
S
Y
P
N
I
-
T
I
N
D
Q
T
-
P
E
L
-
A
E
Y
-----
F
G
S
M
I
-
V
L
D
D
P
R
H
Q
R
L
R
S
I
V
S
R
A
F
T
P
K
V
V
A
R
I
E
A
A
V
R
D
R
A
H
R
L
V
S
S
M
I
A
---
N
N
P
DR
Q
--
A
D
L
V
S
E
L
A
G
P
L
P
L
Q
I
I
C
D
M
M
G
I
P
K
A
D
H
Q
R
I
F
-------
H
W
T
N
V
I
L
---------
G
F
G
D
---
P
D
-
L
-----
A
T
D
F
D
--------
E
F
M
Q
V
S
A
D
I
G
A
Y
A
T
A
L
A
E
D
R
R
V
N
H
H
D
D
L
T
S
S
L
V
-
E
-
A
E
V
--
D
G
E
R
L
S
S
R
E
I
A
S
F
F
I
L
L
V
V
A
G
N
E
T
T
R
N
A
I
T
H
G
V
L
A
L
S
R
Y
P
E
Q
R
D
R
W
W
S
D
F
D
G
-
L
A
P
T
A
V
E
E
I
V
R
W
A
S
P
-
V
V
Y
--
M
R
-
R
T
L
T
Q
D
I
E
L
R
G
T
K
M
A
A
G
D
K
V
S
L
W
Y
C
S
A
N
R
D
E
S
K
F
A
----
D
P
W
T
F
D
L
A
R
N
P
-
N
P
H
L
G
F
G
G
G
-
G
A
H
F
C
L
G
A
N
L
A
R
R
E
I
R
V
A
F
D
E
L
R
--
R
Q
M
P
D
V
-
V
A
--
T
E
E
P
A
R
L
L
S
Q
F
-
I
H
G
I
K
T
L
P
V
T
----
8
PsiBlast_PDB
83.93
33%
-109
- C7 -
4RM4
1
YJIB_BACSU
A:
[26-367]
----------------------
P
F
P
W
Y
E
S
M
R
K
D
A
P
V
S
-----
F
---
D
--
E
------
E
N
Q
V
W
S
V
---
F
L
Y
D
D
V
K
K
V
V
G
D
----
K
E
L
F
S
------
S
C
M
---------
G
N
-------
S
I
I
-
N
M
D
P
P
K
H
T
K
I
R
S
V
V
N
K
A
F
T
P
R
V
M
K
Q
W
E
P
R
I
Q
E
I
T
D
E
L
I
Q
K
F
Q
G
---
R
S
---
E
--
F
D
L
V
H
D
F
S
Y
P
L
P
V
I
V
I
S
E
L
L
G
V
P
S
A
H
M
E
Q
F
K
-------
A
W
S
D
L
L
V
-----
S
T
P
K
D
K
S
E
E
A
E
K
A
-
F
L
E
E
R
D
K
C
E
E
---------
E
L
A
A
F
F
A
G
I
------
I
E
E
K
R
N
-
K
P
E
Q
D
I
I
S
I
L
V
-
E
-------
G
E
K
L
S
G
E
E
L
I
P
F
C
T
L
L
L
V
A
G
N
E
T
T
T
N
L
I
S
N
A
M
Y
S
I
L
E
T
P
G
V
Y
E
E
L
R
S
H
P
E
L
-
M
-
P
Q
A
V
E
E
A
L
R
F
R
A
P
-
A
P
V
--
L
R
-
R
I
A
K
R
D
T
E
I
G
G
H
L
I
K
E
G
D
M
V
L
A
F
V
A
S
A
N
R
D
E
A
K
F
D
----
R
P
H
M
F
D
I
R
R
H
P
-
N
P
H
-
I
A
F
G
H
-
G
I
H
F
C
L
G
A
P
L
A
R
L
E
A
N
I
A
L
T
S
L
I
---------------------------------------