@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1715: (2016-05-04 )
MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITDTNAEILHAAAVEAARVAGAGRGSVAAAADLAAAIPDADLVIEAVVENLAVKQELFERLATLAPDAVLATNTSVLPIGAVTERVEDGSRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVALLTQVGKLPVRVGRDVPGFIGNRLQHALWREAIALVAEGVCDPKTVDLVVRNTIGLRLATLGPLENADYIGLDLTLAIHDAVIPSLNHDPHPSPLLRELVAAGQLGARTGHGFLDWPAGAREATTARLAQHIAAQLQANEKGRGT
Atome Classification :
(38 SA)
.........10........20........30........40..------------.----------..--...50..---------.-------------------.------------------...-------.60------------------.....---....70.--------.......80........90....-....-100-........110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240..---.-----.-.-----.----.--250..---.......260.......270.......280.......290.......300..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLTSHGF
S
R
A
A
V
V
G
A
G
L
M
G
R
R
I
A
G
V
L
A
SAG
L
D
V
A
I
TDTN
A
E
I
L
------------
H
----------
A
A
--
A
V
E
A
A
R
V---------A-------------------G------------------AGR-------G
S
-------------------
V
A
A
A
A
---
D
L
A
A
AIP--------
D
A
D
L
V
I
E
A
V
V
E
N
L
A
V
K
Q
E
L
F
E
R
L
-
A
T
LA-P-D-
A
V
LATN
T
S
V
L
PI
G
A
V
T
E
R
VEDG
S
R
V
I
G
T
HFWNPPDL
I
P
V
V
E
VVPSARTAPD
T
A
D
R
V
V
A
L
L
T
Q
VGKL
P
V
RVGRDV
P
G
F
I
G
N
R
L
Q
H
A
L
W
R
E
A
I
A
L
V
AEGVCDP
K
T
V
D
L
V
V
RNTI
G
L
R
L
A
TLGPLENA
D
Y
I
G
L
D
L
T
L
A
I
H
D
A
VIPS---L-----N-H-----D----P--H--
P
S
---
P
L
L
R
E
L
V
A
AGQLGARTGHGFLDWPAGAR
E
A
T
T
A
R
L
A
Q
H
I
A
A
Q
L
QANEKGRGT
101
HHSearch
90.16
36%
-94
- C3 -
1F0Y
3
HCDH_HUMAN
A:
[12-302]
---
K
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
------------
A
----------
K
S
--
K
K
G
I
E
E
S
---------
L
R
K
V
A
K
K
K
FAEN
P
K
A
G
D
E
F
V
E
------------------
K
T
L
-------
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
F
A
A
E
-
H
-
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
---
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A-
E
-----
N
-
P
-----
L
----
H
--
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----------------------------
97
HHSearch
89.51
33%
-95
- C3 -
4J0E
-
HCDH1_CAEEL
A:
[7-296]
--
A
M
Q
N
I
R
N
V
A
I
V
G
S
G
Q
M
G
S
G
I
A
Q
V
T
A
S
S
G
F
N
V
M
L
A
D
V
N
K
K
A
L
------------
D
----------
R
A
--
M
K
A
I
S
Q
S
---------
V
-------------------
T
H
L
S
K
K
Q
K
G
T
D
K
E
K
S
D
F
V
T
L
T
M
-------
S
R
-------------------
I
K
T
C
N
---
N
V
S
T
A
V
A
--------
D
A
D
L
I
I
E
A
A
I
E
N
I
D
L
K
R
G
I
F
A
Q
I
-
E
Q
S
C
K
K
-
D
-
S
I
L
T
T
N
T
S
S
F
L
L
E
D
V
A
K
G
L
Q
D
K
T
R
F
G
G
L
H
F
F
N
P
V
P
V
M
K
L
L
E
V
I
R
S
D
D
T
S
D
E
T
Y
A
T
L
I
K
F
G
T
A
V
G
K
T
T
V
A
C
-
K
D
S
P
G
F
I
V
N
R
L
L
I
P
Y
F
F
E
A
A
R
M
Y
E
R
G
D
A
S
M
T
D
I
D
E
A
M
K
L
G
A
G
H
P
M
---
G
P
F
E
L
A
D
Y
I
G
L
D
T
V
K
F
V
M
D
G
W
A
A
K
Y
--
P
-----
E
V
Q
-----
L
----
F
--
E
--
A
S
---
P
L
V
D
K
L
V
A
E
G
K
L
G
R
K
T
G
D
G
F
Y
S
Y
-----------------------------
100
HHSearch
89.41
37%
-91
- C3 -
3MOG
1
PAAH_ECOLI
A:
[4-289]
-----
N
V
Q
T
V
A
V
I
G
S
G
T
M
G
A
G
I
A
E
V
A
A
S
H
G
H
Q
V
L
L
Y
D
I
S
A
E
A
L
------------
T
----------
R
A
--
I
D
G
I
H
A
R
---------
L
N
S
R
V
T
R
GKLT
A
E
T
C
-----
E
------------------
R
T
L
-------
K
R
-------------------
L
I
P
V
T
---
D
I
-
H
A
L
A
--------
A
A
D
L
V
I
E
A
A
S
E
R
L
E
V
K
K
A
L
F
A
Q
L
-
A
E
V
C
P
P
-
Q
-
T
L
L
T
T
N
T
S
S
I
S
I
T
A
I
A
A
E
I
K
N
P
E
R
V
A
G
L
H
F
F
N
P
A
P
V
M
K
L
V
E
V
V
S
G
L
A
T
A
A
E
V
V
E
Q
L
C
E
L
T
L
S
W
G
K
Q
P
V
R
C
-
H
S
T
P
G
F
I
V
N
R
V
A
R
P
Y
Y
S
E
A
W
R
A
L
E
E
Q
V
A
A
P
E
V
I
D
A
A
L
R
D
G
A
G
F
P
M
---
G
P
L
E
L
T
D
L
I
G
Q
D
V
N
F
A
V
T
C
S
V
F
N
A
F
W-
Q
-----
E
-
R
-----
R
----
F
--
L
--
P
S
---
L
V
Q
Q
E
L
V
I
G
G
R
L
G
K
K
S
G
L
G
V
Y
D
W
R
A
E
R
-------------------------
102
HHSearch
89.07
34%
-94
* C3 *
4R1N
-
?
A:
[1-281]
------
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
------------
D
----------
R
G
--
I
A
T
I
T
K
S
---------
L
S
K
L
V
A
K
EKIT
E
A
D
K
-----
E
------------------
E
I
L
-------
S
R
-------------------
I
S
G
T
T
---
D
M
-
K
L
A
A
--------
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
-
D
G
I
C
K
P
-
E
-
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
-
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
---
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
--
G
-----
D
-
T
-----
K
----
Y
--
R
--
A
S
---
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
S
----------------------------
42
PsiBlast_CBE
88.34
37%
-93
- C3 -
3MOG
2
PAAH_ECOLI
C:
[9-291]
----------
A
V
I
G
S
G
T
M
G
A
G
I
A
E
V
A
A
S
H
G
H
Q
V
L
L
Y
D
I
S
A
E
A
L
------------
T
----------
R
A
ID
G
I
H
A
R
L
N
---------
S
-------------------
R
------------------
V
T
R
-------
G
K
-------------------
L
T
A
E
T
CER
T
L
K
R
L
I
P
VTDIHALA
A
A
D
L
V
I
E
A
A
S
E
R
L
E
V
K
K
A
L
F
A
Q
L
-
A
E
V
C
-
P
P
Q
-
T
L
L
T
T
N
T
S
S
I
S
I
T
A
I
A
A
E
I
K
N
P
E
R
V
A
G
L
H
F
F
N
P
A
P
V
M
K
L
V
E
V
V
S
G
L
A
T
A
A
E
V
V
E
Q
L
C
E
L
T
L
S
W
G
K
Q
P
V
R
C
-
H
S
T
P
G
F
I
V
N
R
V
A
R
P
Y
Y
S
E
A
W
R
A
L
E
E
Q
V
A
A
P
E
V
I
D
A
A
L
R
D
G
A
G
F
---
P
M
G
P
L
E
L
T
D
L
I
G
Q
D
V
N
F
A
V
T
C
S
V
F
N
A
---
F
-----
W
-
Q
-----
E
----
R
--
R
FL
P
S
---
L
V
Q
Q
E
L
V
I
G
G
R
L
G
K
K
S
G
L
G
V
Y
D
W
R
A
-
E
R
E
A
----------------------
89
Fugue
88.30
35%
-98
- C3 -
1IL0
3
HCDH_HUMAN
A:
[12-302]
---
K
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
------------
A
----------
K
S
--
K
K
G
I
E
E
S
---------
L
-------------------
R
------------------
K
V
A
-------
K
K
K
F
A
EN
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
F
A
A
E
-
H
-
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
Q
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
---
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
--
L
HQ
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----------------------------
9
PsiBlast_PDB
88.29
33%
-101
- C3 -
4R1N
-
?
A:
[1-280]
------
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
------------
D
R
G
I
A
T
I
T
K
S
L
S
K
--
L
V
A
K
E
K
I
---------
T
-------------------
E
------------------
A
D
K
E
E
I
L
---
S
R
-------------------
I
S
G
T
T
---
D
M
K
L
A
-
A
--------
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
-
P
-
E
-
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
-
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
--
L
G
A
N
-
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
---
T
-----
G
-
D
-----
T
----
K
--
Y
R-
A
S
---
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----------------------------
7
PsiBlast_PDB
88.23
33%
-100
- C3 -
4KUG
1
?
A:
[1-280]
------
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
------------
D
R
G
I
A
T
I
T
K
S
L
S
K
--
L
V
A
K
E
K
I
---------
T
-------------------
E
------------------
A
D
K
E
E
I
L
---
S
R
-------------------
I
S
G
T
T
---
D
M
K
L
A
-
A
--------
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
-
P
-
E
-
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
-
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
--
L
G
A
N
-
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
---
T
-----
G
-
D
-----
T
----
K
--
Y
R-
A
S
---
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----------------------------
105
HHSearch
87.93
30%
-94
- C3 -
4B3H
4
?
A:
[338-627]
---
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
------------
A
----------
K
G
--
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
GR
T
T
Q
E
R
S
--------------
D
------------------
A
L
L
-------
A
R
-------------------
I
T
P
T
A
---
D
A
-
A
D
F
K
--------
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
-
E
D
I
V
E
P
-
N
-
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
-
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
V
-
E
P
A
S
I
E
Q
A
G
S
-
Q
A
G
Y
P
A
---
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
A
-----
G
-
G
-----
T
----
Y
--
Q
--
P
H
P
A
E
A
V
V
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
K
-------------------------
10
PsiBlast_PDB
87.28
33%
-100
- C3 -
4KUH
1
?
A:
[1-280]
------
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
------------
D
R
G
I
A
T
I
T
K
S
L
S
K
--
L
V
A
K
E
K
I
---------
T
-------------------
E
------------------
A
D
K
E
E
I
L
---
S
R
-------------------
I
S
G
T
T
---
D
M
K
L
A
-
A
--------
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
-
P
-
E
-
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
-
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
--
L
G
A
N
-
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
---
T
-----
G
-
D
-----
T
----
K
--
Y
R-
A
S
---
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----------------------------
33
PsiBlast_CBE
87.03
33%
-97
- C3 -
4KUH
1
?
D:
[1-280]
------
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
------------
D
RGIATITKSL
S
K
--
L
V
A
K
E
K
I
---------
T
-------------------
E
------------------
A
D
K
EEIL---
S
R
-------------------
I
S
G
T
T
---
D
M
K
L
A
-
A
--------
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
-
P
-
E
-
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
-
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
--
L
G
A
N
-
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
---
T
-----
G
-
D
-----
T
----
K
--
Y
R-
A
S
---
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----------------------------
27
PsiBlast_CBE
86.95
33%
-102
- C3 -
4KUG
1
?
C:
[1-280]
------
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
------------
D
RGIATITKSL
S
K
--
L
V
A
K
E
K
I
---------
T
-------------------
E
------------------
A
D
K
EEIL---
S
R
-------------------
I
S
G
T
T
---
D
M
K
L
A
-
A
--------
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
-
P
-
E
-
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
-
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
--
L
G
A
N
-
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
---
T
-----
G
-
D
-----
T
----
K
--
Y
R-
A
S
---
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----------------------------
8
PsiBlast_PDB
86.76
33%
-100
- C3 -
4KUE
-
?
A:
[1-280]
------
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
------------
D
R
G
I
A
T
I
T
K
S
L
S
K
--
L
V
A
K
E
K
I
---------
T
-------------------
E
------------------
A
D
K
E
E
I
L
---
S
R
-------------------
I
S
G
T
T
---
D
M
K
L
A
-
A
--------
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
-
P
-
E
-
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
-
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
--
L
G
A
N
-
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
---
T
-----
G
-
D
-----
T
----
K
--
Y
R-
A
S
---
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----------------------------
106
HHSearch
86.29
31%
-94
- C3 -
1ZCJ
-
ECHP_RAT
A:
[293-585]
---
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
------------
D
----------
A
A
--
K
K
I
I
T
F
T
---------
L
-------------------
E
K
E
A
S
R
A
H
Q
N
G
Q
A
------
S
A
K
-------
P
K
-------------------
L
R
F
S
S
---
S
T
-
K
E
L
S
--------
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
-
S
A
L
C
K
P
-
G
-
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
-
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
-
S
K
P
E
D
V
D
G
V
L
E
-
E
F
G
F
K
M
---
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
G
L
T
G--
P
SLPPG
T
-
P
VRKRG
N
----
S
--
R
--
Y
S
---
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
-------------------------
39
PsiBlast_CBE
86.12
34%
-100
- C3 -
1M76
3
HCDH_HUMAN
B:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
AKSKKGIEESLR
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
EFVEKTL
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
F
A
-
A
-
E
H
T
I
F
A
S
N
T
C
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
LH
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
28
PsiBlast_CBE
86.12
33%
-101
- C3 -
4KUG
1
?
B:
[1-280]
------
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
------------
D
RGIATITKSL
S
K
--
L
V
A
K
E
K
I
---------
T
-------------------
E
------------------
A
D
K
EEIL---
S
R
-------------------
I
S
G
T
T
---
D
M
K
L
A
-
A
--------
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
-
P
-
E
-
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
-
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
--
L
G
A
N
-
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
---
T
-----
G
-
D
-----
T
----
K
--
Y
R-
A
S
---
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----------------------------
109
HHSearch
85.98
31%
-92
- C3 -
3ZWC
1
ECHP_RAT
A:
[313-605]
---
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
------------
D
----------
A
A
--
K
K
I
I
T
F
T
---------
L
-------------------
E
K
E
A
S
R
A
H
Q
N
G
Q
A
------
S
A
K
-------
P
K
-------------------
L
R
F
S
S
---
S
T
-
K
E
L
S
--------
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
-
S
A
L
C
K
P
-
G
-
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
-
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
-
S
K
P
E
D
V
D
G
V
L
E
-
E
F
G
F
K
M
---
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
G
L
T
G--
P
SLPPG
T
-
P
V----
R
KRGN
S
--
R
--
Y
S
---
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
-------------------------
4
PsiBlast_PDB
85.95
34%
-105
- C3 -
1F14
-
HCDH_HUMAN
A:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
E
C
V
E
K
T
L
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
F
A
-
A
-
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
LH
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
30
PsiBlast_CBE
85.92
33%
-100
- C3 -
4KUH
1
?
G:
[1-280]
------
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
------------
D
RGIATITKSL
S
K
--
L
V
A
K
E
K
I
---------
T
-------------------
E
------------------
A
D
K
EEIL---
S
R
-------------------
I
S
G
T
T
---
D
M
K
L
A
-
A
--------
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
-
P
-
E
-
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
-
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
--
L
G
A
N
-
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
---
T
-----
G
-
D
-----
T
----
K
--
Y
R-
A
S
---
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----------------------------
17
PsiBlast_PDB
85.74
37%
-91
- C3 -
3MOG
1
PAAH_ECOLI
A:
[9-291]
----------
A
V
I
G
S
G
T
M
G
A
G
I
A
E
V
A
A
S
H
G
H
Q
V
L
L
Y
D
I
S
A
E
A
L
------------
T
----------
R
A
I
D
G
I
H
A
R
L
N
---------
S
-------------------
R
------------------
V
T
R
-------
G
K
-------------------
L
T
A
E
T
C
E
R
T
L
K
R
L
I
P
V
TDIHALA
A
A
D
L
V
I
E
A
A
S
E
R
L
E
V
K
K
A
L
F
A
Q
L
-
A
E
V
C
-
P
P
Q
-
T
L
L
T
T
N
T
S
S
I
S
I
T
A
I
A
A
E
I
K
N
P
E
R
V
A
G
L
H
F
F
N
P
A
P
V
M
K
L
V
E
V
V
S
G
L
A
T
A
A
E
V
V
E
Q
L
C
E
L
T
L
S
W
G
K
Q
P
V
R
C
-
H
S
T
P
G
F
I
V
N
R
V
A
R
P
Y
Y
S
E
A
W
R
A
L
E
E
Q
V
A
A
P
E
V
I
D
A
A
L
R
D
G
A
G
F
---
P
M
G
P
L
E
L
T
D
L
I
G
Q
D
V
N
F
A
V
T
C
S
V
F
N
A
---
F
-----
W
-
Q
-----
E
----
R
--
R
FL
P
S
---
L
V
Q
Q
E
L
V
I
G
G
R
L
G
K
K
S
G
L
G
V
Y
D
W
R
A
-
E
R
E
A
----------------------
41
PsiBlast_CBE
85.61
34%
-102
- C3 -
1M75
3
HCDH_HUMAN
B:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
AKSKKGIEESLR
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
EFVEKTL
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
F
A
-
A
-
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
S
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
LH
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
12
PsiBlast_PDB
85.39
34%
-104
- C3 -
1LSJ
1
HCDH_HUMAN
A:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
E
F
V
E
K
T
L
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
Q
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
F
A
-
A
-
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
LH
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
15
PsiBlast_PDB
84.69
34%
-99
- C3 -
1LSO
1
HCDH_HUMAN
A:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
E
F
V
E
K
T
L
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
F
A
-
A
-
E
H
T
I
F
A
S
N
T
A
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
LH
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
25
PsiBlast_CBE
84.54
34%
-98
- C3 -
1F0Y
3
HCDH_HUMAN
B:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
AKSKKGIEESLR
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
EFVEKTL
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
F
A
-
A
-
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
LH
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
26
PsiBlast_CBE
84.51
33%
-97
- C3 -
4KUG
1
?
D:
[1-280]
------
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
------------
D
RGIATITKSL
S
K
--
L
V
A
K
E
K
I
---------
T
-------------------
E
------------------
A
D
K
EEIL---
S
R
-------------------
I
S
G
T
T
---
D
M
K
L
A
-
A
--------
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
-
P
-
E
-
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
-
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
--
L
G
A
N
-
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
---
T
-----
G
-
D
-----
T
----
K
--
Y
R-
A
S
---
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----------------------------
16
PsiBlast_PDB
84.43
34%
-97
- C3 -
1M75
3
HCDH_HUMAN
A:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
E
F
V
E
K
T
L
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
F
A
-
A
-
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
S
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
LH
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
13
PsiBlast_PDB
84.38
34%
-102
- C3 -
3HAD
1
HCDH_HUMAN
A:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
E
F
V
E
K
T
L
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
R
A
-
A
-
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
LH
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
11
PsiBlast_PDB
84.32
34%
-99
- C3 -
1IL0
3
HCDH_HUMAN
A:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
E
F
V
E
K
T
L
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
F
A
-
A
-
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
Q
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
LH
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
5
PsiBlast_PDB
84.14
34%
-101
- C3 -
1F17
1
HCDH_HUMAN
A:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
E
C
V
E
K
T
L
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
F
A
-
A
-
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
LH
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
36
PsiBlast_CBE
84.01
34%
-99
- C3 -
1LSJ
1
HCDH_HUMAN
B:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
AKSKKGIEESLR
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
EFVEKTL
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
Q
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
F
A
-
A
-
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
LH
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
14
PsiBlast_PDB
83.92
34%
-99
- C3 -
1M76
3
HCDH_HUMAN
A:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
E
F
V
E
K
T
L
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
F
A
-
A
-
E
H
T
I
F
A
S
N
T
C
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
LH
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
40
PsiBlast_CBE
83.76
34%
-104
- C3 -
1LSO
1
HCDH_HUMAN
B:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
AKSKKGIEESLR
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
EFVEKTL
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
F
A
-
A
-
E
H
T
I
F
A
S
N
T
A
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
LH
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
38
PsiBlast_CBE
83.62
34%
-104
- C3 -
3HAD
1
HCDH_HUMAN
B:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
AKSKKGIEESLR
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
EFVEKTL
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
R
A
-
A
-
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
LH
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
6
PsiBlast_PDB
83.35
34%
-99
- C3 -
1F0Y
3
HCDH_HUMAN
A:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
E
F
V
E
K
T
L
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
F
A
-
A
-
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
LH
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
37
PsiBlast_CBE
83.26
34%
-97
- C3 -
1IL0
3
HCDH_HUMAN
B:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
AKSKKGIEESLR
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
EFVEKTL
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
F
A
-
A
-
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
Q
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
LH
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
23
PsiBlast_CBE
82.89
34%
-102
- C3 -
1F17
1
HCDH_HUMAN
B:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
AKSKKGIEESLR
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
ECVEKTL
S
T
-------------------
I
A
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
-
D
K
F
A
-
A
-
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
---
D
-----
A
-
E
-----
N
----
P
LH
Q
--
P
S
---
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
2
PsiBlast_PDB
82.49
34%
-102
- C3 -
3HDH
1
HCDH_PIG
A:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
E
F
V
E
K
T
L
S
S
-------------------
I
S
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
-
D
K
F
A
-
A
-
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
L
M
K
L
V
E
V
V
K
T
P
M
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
I
D
G
W
H
E
M
---
D
-----
S
-
Q
-----
N
----
P
LF
Q
--
P
S
---
P
A
M
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------
22
PsiBlast_CBE
80.40
34%
-98
- C3 -
3HDH
1
HCDH_PIG
B:
[20-301]
-----------
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
AKSKKGIEESLR
K
----------
V
A
--
K
K
K
F
A
E
N
---------
P
-------------------
K
------------------
A
G
D
EFVEKTL
S
S
-------------------
I
S
T
S
T
---
D
A
A
S
V
V
H
--------
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
-
D
K
F
A
-
A
-
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
L
M
K
L
V
E
V
V
K
T
P
M
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
---
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
I
D
G
W
H
E
M
---
D
-----
S
-
Q
-----
N
----
P
LF
Q
--
P
S
---
P
A
M
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-----------------------------