@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1785c: (2016-05-05 )
MTTPGEDHAGSFYLPRLEYSTLPMAVDRGVGWKTLRDAGPVVFMNGWYYLTRREDVLAALRNPKVFSSRKALQPPGNPLPVVPLAFDPPEHTRYRRILQPYFSPAALSKALPSLRRHTVAMIDAIAGRGECEAMADLANLFPFQLFLVLYGLPLEDRDRLIGWKDAVIAMSDRPHPTEADVAAARELLEYLTAMVAERRRNPGPDVLSQVQIGEDPLSEIEVLGLSHLLILAGLDTVTAAVGFSLLELARRPQLRAMLRDNPKQIRVFIEEIVRLEPSAPVAPRVTTEPVTVGGMTLPAGSPVRLCMAAVNRDGSDAMSTDELVMDGKVHRHWGFGGGPHRCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS
Atome Classification :
(22 SA)
.........10........20........30.....--.-..40.---.-----......50........60........70..-.--.--....80.....------...90........100.......110.......120......-.130........140.......150.......160.-......170..-...-..-.180....-...-190.......200......---.---210-..---.......220.......230.......240.......250.......260.......270.......280..-......290.......300.......310-.........320.......330.......340.......350.......360.......370......-.380.-...---...390.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTTPGEDHAGSFYLPRLEYSTLP
M
A
VDRGVGWKTLR--D-AG
P
V
V
---
F
-----MN
G
W
Y
Y
L
T
R
R
E
D
V
L
A
A
LRNPKVFSSRKALQ-P--P--GNPL
P
V
V
P
L
AF------DPP
E
H
T
R
Y
R
R
I
L
Q
P
YF
S
P
A
A
L
S
K
A
L
P
S
L
R
R
H
T
V
A
M
I
D
A
IAGR-G
E
-
C
E
A
M
A
D
L
A
N
L
F
P
F
Q
L
F
L
V
L
YGLPLEDRDRLIGW-
K
D
A
V
I
AMS-DR-PHP-TE-
A
D
V
A
A
A
R
E
-
L
L
E
-
Y
L
T
A
M
V
A
E
RRRNP
G
P
D
V
L
S
---
Q
---V---QI---GED
P
L
S
E
I
E
V
L
G
L
S
H
L
L
I
L
A
G
L
D
T
V
T
A
A
V
G
F
S
L
L
E
L
AR
R
P
Q
L
R
A
M
L
RD
N
P
K
Q
I
R
V
F
I
E
E
I
V
RLEPSAPV-AP-RVTTE
P
V
T
VG
G
M
TLPAG
S
P
V
R
L
C
M
A
A
V---NRDGSDAMSTD
E
L
V
MD
G
K
V
H
R
HWGFGGG
P
H
R
C
L
G
S
H
L
A
R
L
E
L
T
L
L
V
G
E
W
L
N
QIPDFELAPDYAPEIRF-PSKSF-ALK---NLPLRWS
19
PsiBlast_PDB
89.34
33%
-113
- C7 -
4MM0
1
?
A:
[48-399]
----------------------------------------------------------
F
L
V
T
R
Y
E
D
V
R
F
V
L
S
D
P
R
-
F
S
V
R
Q
D
L
-----
P
--
G
A
P
R
-
L
T
E
M
T
F
ESVMTT
D
P
P
V
H
T
R
L
R
R
L
L
S
R
D
F
T
A
R
R
I
E
R
M
R
P
R
L
E
E
I
A
E
G
L
L
D
E
M
E
K
K
-
G
A
P
A
D
I
V
E
S
L
A
V
P
F
P
I
T
V
I
C
E
L
L
G
V
P
M
V
D
V
A
R
F
R
G
W
-
A
D
T
M
V
S
L
T
-
G
Y
-----
S
M
-
E
D
W
T
A
A
R
D
-
A
L
E
S
Y
L
D
G
L
V
A
A
K
R
E
N
P
G
S
D
L
L
S
---
A
---
L
V
A
T
A
A
---
E
D
N
E
L
T
D
H
D
V
R
S
L
S
L
I
L
L
L
A
G
Y
E
P
A
S
N
Q
L
G
S
S
V
L
T
L
L
R
F
P
D
R
L
A
E
L
R
R
D
P
G
L
L
P
S
A
V
E
E
L
M
R
Y
A
P
A
G
D
G
-
A
L
F
R
V
T
L
E
D
V
T
I
G
D
T
H
I
P
A
N
S
A
V
L
A
S
T
Q
A
A
---
N
W
D
P
R
R
F
D
D
P
T
G
L
R
L
D
R
P
D
N
Q
H
T
A
L
G
H
G
I
H
F
C
L
G
A
A
L
A
R
V
E
L
Q
V
A
I
G
A
L
L
R
R
F
P
R
L
A
L
A
T
D
E
S
-
G
L
R
W
-
S
S
P
G
S
-
M
L
S
G
F
A
E
I
P
V
T
W
-
7
PsiBlast_PDB
89.29
33%
-125
- C7 -
4L77
4
CINA_CITBR
A:
[45-374]
--------------------------------------------------------
G
H
W
V
V
A
G
Y
K
E
I
Q
A
V
I
Q
N
T
K
A
F
S
N
K
G
V
T
F
-
P
RY
E
--
T
G
E
F
E
L
M
M
A
G
Q
------
D
D
P
V
H
K
K
Y
R
Q
L
V
A
K
P
F
S
P
E
A
T
D
L
F
T
E
Q
L
R
Q
S
T
N
D
L
I
D
A
R
I
E
L
-
G
E
-
G
D
A
A
T
W
L
A
N
E
I
P
A
R
L
T
A
I
L
L
G
L
P
P
E
D
G
D
T
Y
R
R
W
----
V
W
A
I
T
-
H
V
-
E
N
P
-
E
E
G
A
E
I
F
A
--
E
-
L
V
A
-
H
A
R
T
L
I
A
E
R
R
T
N
P
G
N
D
I
M
S
---
R
---
V
I
M
S
K
I
---
D
G
E
S
L
S
E
D
D
L
I
G
F
F
T
I
L
L
L
G
G
I
D
A
T
A
R
F
L
S
S
V
F
W
R
L
A
W
D
I
E
L
R
R
R
L
I
A
H
P
E
L
I
P
N
A
V
D
E
L
L
R
F
Y
G
P
A
M
V
-
G
--
R
L
V
T
Q
E
V
T
V
G
D
I
T
M
K
P
G
Q
T
A
M
L
W
F
P
I
A
---
S
R
D
R
S
A
F
D
S
P
D
N
I
V
I
E
R
T
P
N
R
H
L
S
L
G
H
G
I
H
R
C
L
G
A
H
L
I
R
V
E
A
R
V
A
I
T
E
F
L
K
R
I
P
E
F
S
L
D
P
N
K
E
C
E
-----------------------
82
HHSearch
89.20
31%
-100
- C7 -
4C9L
3
?
A:
[21-415]
--------
P
G
H
L
I
R
E
I
D
A
Y
D
L
D
G
L
E
Q
G
F
H
E
A
W
K
R
V
Q
Q-
P
D
T
P
P
L
V
---
W
T
PF--
T
G
G
H
W
I
A
T
R
G
T
L
I
D
E
I
Y
R
S
P
E
R
F
S
S
R
V
I
W
V
-
P
--
R
E
A
G
E
A
Y
D
M
V
P
T
K
L
------
D
P
P
E
H
T
P
Y
R
K
A
I
D
K
G
L
N
L
A
E
I
R
K
L
E
D
Q
I
R
T
I
A
V
E
I
I
E
G
F
A
D
R
-
G
H
-
C
E
F
G
S
E
F
S
T
V
F
P
V
R
V
F
L
A
L
A
G
L
P
V
E
D
A
T
K
L
G
L
L
-
A
N
E
M
T
R
P
S
-
G
N
T
P
E
E
Q
G
R
-
S
L
E
A
A
N
K
G
-
F
F
E
-
Y
V
A
P
I
I
A
A
R
R
G
G
S
G
T
D
L
I
T
---
R
---
I
---
L
N
VEI
D
G
K
P
M
P
D
D
R
A
L
G
L
V
S
L
L
L
L
G
G
L
D
T
V
V
N
F
L
G
F
M
M
I
Y
L
S
R
H
P
E
T
V
A
E
M
R
R
E
P
L
K
L
Q
R
G
V
E
E
L
F
R
R
F
A
V
V
S
D
--
A
-
R
Y
V
V
S
D
M
E
F
H
G
T
M
L
K
E
G
D
L
I
L
L
P
T
A
L
H
---
G
L
D
D
R
H
H
D
D
P
M
T
V
D
L
S
R
R
D
V
T
H
S
T
F
A
Q
G
P
H
R
C
A
G
M
H
L
A
R
L
E
V
T
V
M
L
Q
E
W
L
A
R
I
P
E
F
R
L
K
D
R
A
V
--
P
I
Y
-
H
S
G
I
V
A
A
V
E
---
N
I
P
L
E
W
E
5
PsiBlast_PDB
89.19
33%
-123
- C7 -
4FYZ
5
CINA_CITBR
A:
[45-374]
--------------------------------------------------------
G
H
W
V
V
A
G
Y
K
E
I
Q
A
V
I
Q
N
T
K
A
F
S
N
K
G
V
T
F
-
P
RY
E
--
T
G
E
F
E
L
M
M
A
G
Q
------
D
D
P
V
H
K
K
Y
R
Q
L
V
A
K
P
F
S
P
E
A
T
D
L
F
T
E
Q
L
R
Q
S
T
N
D
L
I
D
A
R
I
E
L
-
G
E
-
G
D
A
A
T
W
L
A
N
E
I
P
A
R
L
T
A
I
L
L
G
L
P
P
E
D
G
D
T
Y
R
R
W
----
V
W
A
I
T
-
H
V
-
E
N
P
-
E
E
G
A
E
I
F
A
--
E
-
L
V
A
-
H
A
R
T
L
I
A
E
R
R
T
N
P
G
N
D
I
M
S
---
R
---
V
I
M
S
K
I
---
D
G
E
S
L
S
E
D
D
L
I
G
F
F
T
I
L
L
L
G
G
I
D
N
T
A
R
F
L
S
S
V
F
W
R
L
A
W
D
I
E
L
R
R
R
L
I
A
H
P
E
L
I
P
N
A
V
D
E
L
L
R
F
Y
G
P
A
M
V
-
G
--
R
L
V
T
Q
E
V
T
V
G
D
I
T
M
K
P
G
Q
T
A
M
L
W
F
P
I
A
---
S
R
D
R
S
A
F
D
S
P
D
N
I
V
I
E
R
T
P
N
R
H
L
S
L
G
H
G
I
H
R
C
L
G
A
H
L
I
R
V
E
A
R
V
A
I
T
E
F
L
K
R
I
P
E
F
S
L
D
P
N
K
E
C
E
-----------------------
40
PsiBlast_CBE
89.14
33%
-112
- C7 -
4MM0
1
?
B:
[48-399]
----------------------------------------------------------
F
L
V
T
R
Y
E
D
V
R
F
V
L
S
D
P
R
-
F
S
V
R
Q
D
L
-----
P
--
G
A
P
R
-
L
T
E
M
T
F
ESVMTT
D
P
P
V
H
T
R
L
R
R
L
L
S
R
D
F
T
A
R
R
I
E
R
M
R
P
R
L
E
E
I
A
E
G
L
L
D
E
M
E
K
K
-
G
A
P
A
D
I
V
E
S
L
A
V
P
F
P
I
T
V
I
C
E
L
L
G
V
P
M
V
D
V
A
R
F
R
G
W
-
A
D
T
M
V
S
L
T
-
G
Y
-----
S
M
-
E
D
W
T
A
A
R
D
-
A
L
E
S
Y
L
D
G
L
V
A
A
K
R
E
N
P
G
S
D
L
L
S
---
A
---
L
V
A
T
A
A
---
E
D
N
E
L
T
D
H
D
V
R
S
L
S
L
I
L
L
L
A
G
Y
E
P
A
S
N
Q
L
G
S
S
V
L
T
L
L
R
F
P
D
R
L
A
E
L
R
R
D
P
G
L
L
P
S
A
V
E
E
L
M
R
Y
A
P
A
G
D
G
-
A
L
F
R
V
T
L
E
D
V
T
I
G
D
T
H
I
P
A
N
S
A
V
L
A
S
T
Q
A
A
---
N
W
D
P
R
R
F
D
D
P
T
G
L
R
L
D
R
P
D
N
Q
H
T
A
L
G
H
G
I
H
F
C
L
G
A
A
L
A
R
V
E
L
Q
V
A
I
G
A
L
L
R
R
F
P
R
L
A
L
A
T
D
E
S
-
G
L
R
W
-
S
S
P
G
S
-
M
L
S
G
F
A
E
I
P
V
T
W
-
25
PsiBlast_CBE
88.95
33%
-120
- C7 -
4FMX
4
CINA_CITBR
B:
[45-374]
--------------------------------------------------------
G
H
W
V
V
A
G
Y
K
E
I
Q
A
V
I
Q
N
T
K
A
F
S
N
K
G
V
T
F
-
P
RY
E
--
T
G
E
F
E
L
M
M
A
G
Q
------
D
D
P
V
H
K
K
Y
R
Q
L
V
A
K
P
F
S
P
E
A
T
D
L
F
T
E
Q
L
R
Q
S
T
N
D
L
I
D
A
R
I
E
L
-
G
E
-
G
D
A
A
T
W
L
A
N
E
I
P
A
R
L
T
A
I
L
L
G
L
P
P
E
D
G
D
T
Y
R
R
W
----
V
W
A
I
T
-
H
V
-
E
N
P
-
E
E
G
A
E
I
F
A
--
E
-
L
V
A
-
H
A
R
T
L
I
A
E
R
R
T
N
P
G
N
D
I
M
S
---
R
---
V
IMS
K
I
---
D
G
E
S
L
S
E
D
D
L
I
G
F
F
T
I
L
L
L
G
G
I
D
N
T
A
R
F
L
S
S
V
F
W
R
L
A
W
D
I
E
L
R
R
R
L
I
A
H
P
E
L
I
P
N
A
V
D
E
L
L
R
F
Y
G
P
A
M
V
-
G
--
R
L
V
T
Q
E
V
T
V
G
D
I
T
M
K
P
G
Q
T
A
M
L
W
F
P
I
A
---
S
R
D
R
S
A
F
D
S
P
D
N
I
V
I
E
R
T
P
N
R
H
L
S
L
G
H
G
I
H
R
C
L
G
A
H
L
I
R
V
E
A
R
V
A
I
T
E
F
L
K
R
I
P
E
F
S
L
D
P
N
K
E
C
E
-----------------------
23
PsiBlast_CBE
88.85
33%
-122
- C7 -
1T2B
2
CINA_CITBR
B:
[44-373]
--------------------------------------------------------
G
H
W
V
V
A
G
Y
K
E
I
Q
A
V
I
Q
N
T
K
A
F
S
N
K
G
V
T
F
-
P
RY
E
--
T
G
E
F
E
L
M
M
A
G
Q
------
D
D
P
V
H
K
K
Y
R
Q
L
V
A
K
P
F
S
P
E
A
T
D
L
F
T
E
Q
L
R
Q
S
T
N
D
L
I
D
A
R
I
E
L
-
G
E
-
G
D
A
A
T
W
L
A
N
E
I
P
A
R
L
T
A
I
L
L
G
L
P
P
E
D
G
D
T
Y
R
R
W
----
V
W
A
I
T
-
H
V
-
E
N
P
-
E
E
G
A
E
I
F
A
--
E
-
L
V
A
-
H
A
R
T
L
I
A
E
R
R
T
N
P
G
N
D
I
M
S
---
R
---
V
IMS
K
I
---
D
G
E
S
L
S
E
D
D
L
I
G
F
F
T
I
L
L
L
G
G
I
D
N
T
A
R
F
L
S
S
V
F
W
R
L
A
W
D
I
E
L
R
R
R
L
I
A
H
P
E
L
I
P
N
A
V
D
E
L
L
R
F
Y
G
P
A
M
V
-
G
--
R
L
V
T
Q
E
V
T
V
G
D
I
T
M
K
P
G
Q
T
A
M
L
W
F
P
I
A
---
S
R
D
R
S
A
F
D
S
P
D
N
I
V
I
E
R
T
P
N
R
H
L
S
L
G
H
G
I
H
R
C
L
G
A
H
L
I
R
V
E
A
R
V
A
I
T
E
F
L
K
R
I
P
E
F
S
L
D
P
N
K
E
C
E
-----------------------
61
PsiBlast_CBE
88.74
31%
-105
- C7 -
3NV6
3
?
A:
[94-448]
------------------------------------------------
F
-----
T
G
G
H
W
I
A
T
N
G
D
T
V
K
E
V
Y
S
D
P
T
R
F
S
S
E
V
I
F
L
-
P
--
K
E
A
G
E
K
Y
Q
M
V
P
T
K
M
------
D
P
P
E
H
T
P
Y
R
K
A
L
D
K
G
L
N
L
A
K
I
R
K
V
E
D
K
V
R
E
V
A
S
S
L
I
D
S
F
A
A
R
-
G
E
-
C
D
F
A
A
E
Y
A
E
L
F
P
V
H
V
F
M
A
L
A
D
L
P
L
E
D
I
P
V
L
S
E
Y
A
R
Q
M
T
R
P
E
G
-
N
T
-
P
E
E
-
M
A
-
T
D
L
E
A
G
N
N
G
F
Y
A
-
Y
V
D
P
I
I
R
A
R
V
G
G
D
G
D
D
L
I
T
L
M
V
N
---
S
---
E
I
---
N
G
E
R
I
A
H
D
K
A
Q
G
L
I
S
L
L
L
L
G
G
L
D
T
V
V
N
F
L
S
F
F
M
I
H
L
A
R
H
P
E
L
V
A
E
L
R
S
D
P
L
K
L
M
R
G
A
E
E
M
F
R
R
F
P
V
V
S
E
-
A
--
R
M
V
A
K
D
Q
E
Y
K
G
V
F
L
K
R
G
D
M
I
L
L
P
T
A
L
H
---
G
L
D
D
A
A
N
P
E
P
W
K
L
D
F
S
R
R
S
I
S
H
S
T
F
G
G
G
P
H
R
C
A
G
M
H
L
A
R
M
E
V
I
V
T
L
E
E
W
L
K
R
I
P
E
F
S
F
K
E
G
E
T
P
-
I
Y
H
-
S
G
I
V
A
-
A
V
E
---
N
V
P
L
V
W
-
86
HHSearch
88.71
31%
-102
* C7 *
4MM0
1
?
A:
[18-399]
----------------------
A
V
P
T
A
I
P
P
L
Y
E
E
L
R
--
E
-
T
E
R
V
A
---
A
I
T
M
AT
G
D
P
G
F
L
V
T
R
Y
E
D
V
R
F
V
L
S
D
P
R
-
F
S
V
R
Q
D
L
P
G
A
--
P
RL
T
E
M
T
F
E
S
V
M
T
T
------
D
P
P
V
H
T
R
L
R
R
L
L
S
R
D
F
T
A
R
R
I
E
R
M
R
P
R
L
E
E
I
A
E
G
L
L
D
E
M
E
K
K
G
A
P
-
A
D
I
V
E
S
L
A
V
P
F
P
I
T
V
I
C
E
L
L
G
V
P
M
V
D
V
A
R
F
R
G
W
-
A
D
T
M
V
S
L
T
-
G
Y
---
S
-
M
E
-
D
W
T
A
A
R
D
A
-
L
E
S
-
Y
L
D
G
L
V
A
A
K
R
E
N
P
G
S
D
L
L
S
---
A
---
L
---
V
A
T
A
A
E
D
N
E
L
T
D
H
D
V
R
S
L
S
L
I
L
L
L
A
G
Y
E
P
A
S
N
Q
L
G
S
S
V
L
T
L
L
R
F
P
D
R
L
A
E
L
R
R
D
P
G
L
L
P
S
A
V
E
E
L
M
R
Y
A
P
A
G
D
G
A
L
F
-
R
V
T
L
E
D
V
T
I
G
D
T
H
I
P
A
N
S
A
V
L
A
S
T
Q
A
A
---
N
W
D
P
R
R
F
D
D
P
T
G
L
R
L
D
R
P
D
N
Q
H
T
A
L
G
H
G
I
H
F
C
L
G
A
A
L
A
R
V
E
L
Q
V
A
I
G
A
L
L
R
R
F
P
R
L
A
L
A
T
D
E
S
G
L
R
W
S
S
P
G
S
M
L
S
G
F
A
---
E
I
P
V
T
W
-
24
PsiBlast_CBE
88.68
33%
-123
- C7 -
4FYZ
5
CINA_CITBR
B:
[45-374]
--------------------------------------------------------
G
H
W
V
V
A
G
Y
K
E
I
Q
A
V
I
Q
N
T
K
A
F
S
N
K
G
V
T
F
-
P
RY
E
--
T
G
E
F
E
L
M
M
A
G
Q
------
D
D
P
V
H
K
K
Y
R
Q
L
V
A
K
P
F
S
P
E
A
T
D
L
F
T
E
Q
L
R
Q
S
T
N
D
L
I
D
A
R
I
E
L
-
G
E
-
G
D
A
A
T
W
L
A
N
E
I
P
A
R
L
T
A
I
L
L
G
L
P
P
E
D
G
D
T
Y
R
R
W
----
V
W
A
I
T
-
H
V
-
E
N
P
-
E
E
G
A
E
I
F
A
--
E
-
L
V
A
-
H
A
R
T
L
I
A
E
R
R
T
N
P
G
N
D
I
M
S
---
R
---
V
IMS
K
I
---
D
G
E
S
L
S
E
D
D
L
I
G
F
F
T
I
L
L
L
G
G
I
D
N
T
A
R
F
L
S
S
V
F
W
R
L
A
W
D
I
E
L
R
R
R
L
I
A
H
P
E
L
I
P
N
A
V
D
E
L
L
R
F
Y
G
P
A
M
V
-
G
--
R
L
V
T
Q
E
V
T
V
G
D
I
T
M
K
P
G
Q
T
A
M
L
W
F
P
I
A
---
S
R
D
R
S
A
F
D
S
P
D
N
I
V
I
E
R
T
P
N
R
H
L
S
L
G
H
G
I
H
R
C
L
G
A
H
L
I
R
V
E
A
R
V
A
I
T
E
F
L
K
R
I
P
E
F
S
L
D
P
N
K
E
C
E
-----------------------
2
PsiBlast_PDB
88.63
33%
-121
- C7 -
4LHT
6
CINA_CITBR
A:
[45-374]
--------------------------------------------------------
G
H
W
V
V
A
G
Y
K
E
I
Q
A
V
I
Q
N
T
K
A
F
S
N
K
G
V
T
F
-
P
RF
E
--
T
G
E
F
E
L
M
M
A
G
Q
------
D
D
P
V
H
K
K
Y
R
Q
L
V
A
K
P
F
S
P
E
A
T
D
L
F
T
E
Q
L
R
Q
S
T
N
D
L
I
D
A
R
I
E
L
-
G
E
-
G
D
A
A
T
W
L
A
N
E
I
P
A
R
L
T
A
I
L
L
G
L
P
P
E
D
G
D
T
Y
R
R
W
----
V
W
A
I
T
-
H
V
-
E
N
P
-
E
E
G
A
E
I
F
A
--
E
-
L
V
A
-
H
A
R
T
L
I
A
E
R
R
T
N
P
G
N
D
I
M
S
---
R
---
V
I
M
S
K
I
---
D
G
E
S
L
S
E
D
D
L
I
G
F
F
T
I
L
L
L
G
G
I
D
N
T
A
R
F
L
S
S
V
F
W
R
L
A
W
D
I
E
L
R
R
R
L
I
A
H
P
E
L
I
P
N
A
V
D
E
L
L
R
F
Y
G
P
A
M
V
-
G
--
R
L
V
T
Q
E
V
T
V
G
D
I
T
M
K
P
G
Q
T
A
M
L
W
F
P
I
A
---
S
R
D
R
S
A
F
D
S
P
D
N
I
V
I
E
R
T
P
N
R
H
L
S
L
G
H
G
I
H
R
C
L
G
A
H
L
I
R
V
E
A
R
V
A
I
T
E
F
L
K
R
I
P
E
F
S
L
D
P
N
K
E
C
E
-----------------------
29
PsiBlast_CBE
88.53
33%
-126
- C7 -
4L77
5
CINA_CITBR
B:
[45-374]
--------------------------------------------------------
G
H
W
V
V
A
G
Y
K
E
I
Q
A
V
I
Q
N
T
K
A
F
S
N
K
G
V
T
F
-
P
RY
E
--
T
G
E
F
E
L
M
M
A
G
Q
------
D
D
P
V
H
K
K
Y
R
Q
L
V
A
K
P
F
S
P
E
A
T
D
L
F
T
E
Q
L
R
Q
S
T
N
D
L
I
D
A
R
I
E
L
-
G
E
-
G
D
A
A
T
W
L
A
N
E
I
P
A
R
L
T
A
I
L
L
G
L
P
P
E
D
G
D
T
Y
R
R
W
----
V
W
A
I
T
-
H
V
-
E
N
P
-
E
E
G
A
E
I
F
A
--
E
-
L
V
A
-
H
A
R
T
L
I
A
E
R
R
T
N
P
G
N
D
I
M
S
---
R
---
V
I
M
S
K
I
---
D
G
E
S
L
S
E
D
D
L
I
G
F
F
T
I
L
L
L
G
G
I
D
A
T
A
R
F
L
S
S
V
F
W
R
L
A
W
D
I
E
L
R
R
R
L
I
A
H
P
E
L
I
P
N
A
V
D
E
L
L
R
F
Y
G
P
A
M
V
-
G
--
R
L
V
T
Q
E
V
T
V
G
D
I
T
M
K
P
G
Q
T
A
M
L
W
F
P
I
A
---
S
R
D
R
S
A
F
D
S
P
D
N
I
V
I
E
R
T
P
N
R
H
L
S
L
G
H
G
I
H
R
C
L
G
A
H
L
I
R
V
E
A
R
V
A
I
T
E
F
L
K
R
I
P
E
F
S
L
D
P
N
K
E
C
E
-----------------------
6
PsiBlast_PDB
88.45
33%
-122
- C7 -
4FMX
5
CINA_CITBR
A:
[45-374]
--------------------------------------------------------
G
H
W
V
V
A
G
Y
K
E
I
Q
A
V
I
Q
N
T
K
A
F
S
N
K
G
V
T
F
-
P
RY
E
--
T
G
E
F
E
L
M
M
A
G
Q
------
D
D
P
V
H
K
K
Y
R
Q
L
V
A
K
P
F
S
P
E
A
T
D
L
F
T
E
Q
L
R
Q
S
T
N
D
L
I
D
A
R
I
E
L
-
G
E
-
G
D
A
A
T
W
L
A
N
E
I
P
A
R
L
T
A
I
L
L
G
L
P
P
E
D
G
D
T
Y
R
R
W
----
V
W
A
I
T
-
H
V
-
E
N
P
-
E
E
G
A
E
I
F
A
--
E
-
L
V
A
-
H
A
R
T
L
I
A
E
R
R
T
N
P
G
N
D
I
M
S
---
R
---
V
I
M
S
K
I
---
D
G
E
S
L
S
E
D
D
L
I
G
F
F
T
I
L
L
L
G
G
I
D
N
T
A
R
F
L
S
S
V
F
W
R
L
A
W
D
I
E
L
R
R
R
L
I
A
H
P
E
L
I
P
N
A
V
D
E
L
L
R
F
Y
G
P
A
M
V
-
G
--
R
L
V
T
Q
E
V
T
V
G
D
I
T
M
K
P
G
Q
T
A
M
L
W
F
P
I
A
---
S
R
D
R
S
A
F
D
S
P
D
N
I
V
I
E
R
T
P
N
R
H
L
S
L
G
H
G
I
H
R
C
L
G
A
H
L
I
R
V
E
A
R
V
A
I
T
E
F
L
K
R
I
P
E
F
S
L
D
P
N
K
E
C
E
-----------------------
35
PsiBlast_CBE
88.42
33%
-107
- C7 -
3LXI
4
?
B:
[43-415]
------------------------------
A
W
K
R
V
Q
QP
D
-
T
P
P
L
V
W
T
P
F
-----
T
G
G
H
W
I
A
T
R
G
T
L
I
D
E
I
Y
R
S
P
E
R
F
S
S
R
V
I
W
V
-
P
R
E
A
--
G
E
A
Y
D
M
V
P
T
K
L
------
D
P
P
E
H
T
P
Y
R
K
A
I
D
K
G
L
N
L
A
E
I
R
K
L
E
D
Q
I
R
T
I
A
V
E
I
I
E
G
F
A
D
R
-
G
H
-
C
E
F
G
S
E
F
S
T
V
F
P
V
R
V
F
L
A
L
A
G
L
P
V
E
D
A
T
K
L
G
L
L
-
A
N
E
M
T
R
P
S
G
N
T
-
P
E
E
-
Q
G
-
R
S
L
E
A
A
N
K
G
F
F
E
-
Y
V
A
P
I
I
A
A
R
R
G
G
S
G
T
D
L
I
T
---
R
I
L
N
V
---
E
I
---
D
G
K
P
M
P
D
D
R
A
L
G
L
V
S
L
L
L
L
G
G
L
D
T
V
V
N
F
L
G
F
M
M
I
Y
L
S
R
H
P
E
T
V
A
E
M
R
R
E
P
L
K
L
Q
R
G
V
E
E
L
F
R
R
F
A
V
V
S
D
-
A
R
-
Y
V
V
S
D
-
M
E
F
H
G
T
M
L
K
E
G
D
L
I
L
L
P
T
A
L
H
G
L
D
D
R
H
H
D
D
P
M
T
V
D
---
L
S
R
R
D
V
T
H
S
T
F
A
Q
G
P
H
R
C
A
G
M
H
L
A
R
L
E
V
T
V
M
L
Q
E
W
L
A
R
I
P
E
F
R
L
K
-
D
R
A
V
P
I
Y
H
-
S
G
I
V
A
-
A
V
E
---
N
I
P
L
E
W
E
31
PsiBlast_CBE
88.40
33%
-123
- C7 -
3BDZ
2
CINA_CITBR
B:
[44-373]
--------------------------------------------------------
G
H
W
V
V
A
G
Y
K
E
I
Q
A
V
I
Q
N
T
K
A
F
S
N
K
G
V
T
F
-
P
RY
E
--
T
G
E
F
E
L
M
M
A
G
Q
------
D
D
P
V
H
K
K
Y
R
Q
L
V
A
K
P
F
S
P
E
A
T
D
L
F
T
E
Q
L
R
Q
S
T
N
D
L
I
D
A
R
I
E
L
-
G
E
-
G
D
A
A
T
W
L
A
N
E
I
P
A
R
L
T
A
I
L
L
G
L
P
P
E
D
G
D
T
Y
R
R
W
----
V
W
A
I
T
-
H
V
-
E
N
P
-
E
E
G
A
E
I
F
A
--
E
-
L
V
A
-
H
A
R
T
L
I
A
E
R
R
T
N
P
G
N
D
I
M
S
---
R
---
V
IMS
K
I
---
D
G
E
S
L
S
E
D
D
L
I
G
F
F
T
I
L
L
L
G
G
I
D
A
T
A
R
F
L
S
S
V
F
W
R
L
A
W
D
I
E
L
R
R
R
L
I
A
H
P
E
L
I
P
N
A
V
D
E
L
L
R
F
Y
G
P
A
M
V
-
G
--
R
L
V
T
Q
E
V
T
V
G
D
I
T
M
K
P
G
Q
T
A
M
L
W
F
P
I
A
---
S
R
D
R
S
A
F
D
S
P
D
N
I
V
I
E
R
T
P
N
R
H
L
S
L
G
H
G
I
H
R
C
L
G
A
H
L
I
R
V
E
A
R
V
A
I
T
E
F
L
K
R
I
P
E
F
S
L
D
P
N
K
E
C
E
-----------------------
33
PsiBlast_CBE
88.37
33%
-107
- C7 -
4C9L
3
?
B:
[43-415]
------------------------------
A
W
K
R
V
Q
QP
D
-
T
P
P
L
V
W
T
P
F
-----
T
G
G
H
W
I
A
T
R
G
T
L
I
D
E
I
Y
R
S
P
E
R
F
S
S
R
V
I
W
V
-
P
R
E
A
--
G
E
A
Y
D
M
V
P
T
K
L
------
D
P
P
E
H
T
P
Y
R
K
A
I
D
K
G
L
N
L
A
E
I
R
K
L
E
D
Q
I
R
T
I
A
V
E
I
I
E
G
F
A
D
R
-
G
H
-
C
E
F
G
S
E
F
S
T
V
F
P
V
R
V
F
L
A
L
A
G
L
P
V
E
D
A
T
K
L
G
L
L
-
A
N
E
M
T
R
P
S
G
N
T
-
P
E
E
-
Q
G
-
R
S
L
E
A
A
N
K
G
F
F
E
-
Y
V
A
P
I
I
A
A
R
R
G
G
S
G
T
D
L
I
T
---
R
I
L
N
V
---
E
I
---
D
G
K
P
M
P
D
D
R
A
L
G
L
V
S
L
L
L
L
G
G
L
D
T
V
V
N
F
L
G
F
M
M
I
Y
L
S
R
H
P
E
T
V
A
E
M
R
R
E
P
L
K
L
Q
R
G
V
E
E
L
F
R
R
F
A
V
V
S
D
-
A
R
-
Y
V
V
S
D
-
M
E
F
H
G
T
M
L
K
E
G
D
L
I
L
L
P
T
A
L
H
G
L
D
D
R
H
H
D
D
P
M
T
V
D
---
L
S
R
R
D
V
T
H
S
T
F
A
Q
G
P
H
R
C
A
G
M
H
L
A
R
L
E
V
T
V
M
L
Q
E
W
L
A
R
I
P
E
F
R
L
K
-
D
R
A
V
P
I
Y
H
-
S
G
I
V
A
-
A
V
E
---
N
I
P
L
E
W
E
3
PsiBlast_PDB
88.34
33%
-121
- C7 -
1T2B
2
CINA_CITBR
A:
[44-373]
--------------------------------------------------------
G
H
W
V
V
A
G
Y
K
E
I
Q
A
V
I
Q
N
T
K
A
F
S
N
K
G
V
T
F
-
P
RY
E
--
T
G
E
F
E
L
M
M
A
G
Q
------
D
D
P
V
H
K
K
Y
R
Q
L
V
A
K
P
F
S
P
E
A
T
D
L
F
T
E
Q
L
R
Q
S
T
N
D
L
I
D
A
R
I
E
L
-
G
E
-
G
D
A
A
T
W
L
A
N
E
I
P
A
R
L
T
A
I
L
L
G
L
P
P
E
D
G
D
T
Y
R
R
W
----
V
W
A
I
T
-
H
V
-
E
N
P
-
E
E
G
A
E
I
F
A
--
E
-
L
V
A
-
H
A
R
T
L
I
A
E
R
R
T
N
P
G
N
D
I
M
S
---
R
---
V
I
M
S
K
I
---
D
G
E
S
L
S
E
D
D
L
I
G
F
F
T
I
L
L
L
G
G
I
D
N
T
A
R
F
L
S
S
V
F
W
R
L
A
W
D
I
E
L
R
R
R
L
I
A
H
P
E
L
I
P
N
A
V
D
E
L
L
R
F
Y
G
P
A
M
V
-
G
--
R
L
V
T
Q
E
V
T
V
G
D
I
T
M
K
P
G
Q
T
A
M
L
W
F
P
I
A
---
S
R
D
R
S
A
F
D
S
P
D
N
I
V
I
E
R
T
P
N
R
H
L
S
L
G
H
G
I
H
R
C
L
G
A
H
L
I
R
V
E
A
R
V
A
I
T
E
F
L
K
R
I
P
E
F
S
L
D
P
N
K
E
C
E
-----------------------
36
PsiBlast_CBE
88.27
33%
-108
- C7 -
3LXH
4
?
B:
[43-415]
------------------------------
A
W
K
R
V
Q
QP
D
-
T
P
P
L
V
W
T
P
F
-----
T
G
G
H
W
I
A
T
R
G
T
L
I
D
E
I
Y
R
S
P
E
R
F
S
S
R
V
I
W
V
-
P
R
E
A
--
G
E
A
Y
D
M
V
P
T
K
L
------
D
P
P
E
H
T
P
Y
R
K
A
I
D
K
G
L
N
L
A
E
I
R
K
L
E
D
Q
I
R
T
I
A
V
E
I
I
E
G
F
A
D
R
-
G
H
-
C
E
F
G
S
E
F
S
T
V
F
P
V
R
V
F
L
A
L
A
G
L
P
V
E
D
A
T
K
L
G
L
L
-
A
N
E
M
T
R
P
S
G
N
T
-
P
E
E
-
Q
G
-
R
S
L
E
A
A
N
K
G
F
F
E
-
Y
V
A
P
I
I
A
A
R
R
G
G
S
G
T
D
L
I
T
---
R
I
L
N
V
---
E
I
---
D
G
K
P
M
P
D
D
R
A
L
G
L
V
S
L
L
L
L
G
G
L
D
T
V
V
N
F
L
G
F
M
M
I
Y
L
S
R
H
P
E
T
V
A
E
M
R
R
E
P
L
K
L
Q
R
G
V
E
E
L
F
R
R
F
A
V
V
S
D
-
A
R
-
Y
V
V
S
D
-
M
E
F
H
G
T
M
L
K
E
G
D
L
I
L
L
P
T
A
L
H
G
L
D
D
R
H
H
D
D
P
M
T
V
D
---
L
S
R
R
D
V
T
H
S
T
F
A
Q
G
P
H
R
C
A
G
M
H
L
A
R
L
E
V
T
V
M
L
Q
E
W
L
A
R
I
P
E
F
R
L
K
-
D
R
A
V
P
I
Y
H
-
S
G
I
V
A
-
A
V
E
---
N
I
P
L
E
W
E
12
PsiBlast_PDB
88.24
33%
-104
- C7 -
3LXI
5
?
A:
[43-415]
------------------------------
A
W
K
R
V
Q
QP
D
-
T
P
P
L
V
W
T
P
F
-----
T
G
G
H
W
I
A
T
R
G
T
L
I
D
E
I
Y
R
S
P
E
R
F
S
S
R
V
I
W
V
-
P
R
E
A
--
G
E
A
Y
D
M
V
P
T
K
L
------
D
P
P
E
H
T
P
Y
R
K
A
I
D
K
G
L
N
L
A
E
I
R
K
L
E
D
Q
I
R
T
I
A
V
E
I
I
E
G
F
A
D
R
-
G
H
-
C
E
F
G
S
E
F
S
T
V
F
P
V
R
V
F
L
A
L
A
G
L
P
V
E
D
A
T
K
L
G
L
L
-
A
N
E
M
T
R
P
S
G
N
T
-
P
E
E
-
Q
G
-
R
S
L
E
A
A
N
K
G
F
F
E
-
Y
V
A
P
I
I
A
A
R
R
G
G
S
G
T
D
L
I
T
---
R
I
L
N
V
---
E
I
---
D
G
K
P
M
P
D
D
R
A
L
G
L
V
S
L
L
L
L
G
G
L
D
T
V
V
N
F
L
G
F
M
M
I
Y
L
S
R
H
P
E
T
V
A
E
M
R
R
E
P
L
K
L
Q
R
G
V
E
E
L
F
R
R
F
A
V
V
S
D
-
A
R
-
Y
V
V
S
D
-
M
E
F
H
G
T
M
L
K
E
G
D
L
I
L
L
P
T
A
L
H
GLD
D
R
H
H
D
D
P
M
T
V
D
---
L
S
R
R
D
V
T
H
S
T
F
A
Q
G
P
H
R
C
A
G
M
H
L
A
R
L
E
V
T
V
M
L
Q
E
W
L
A
R
I
P
E
F
R
L
K
-
D
R
A
V
P
I
Y
H
-
S
G
I
V
A
-
A
V
E
---
N
I
P
L
E
W
E
38
PsiBlast_CBE
88.22
32%
-108
- C7 -
4C9N
3
?
B:
[43-415]
------------------------------
A
W
K
R
V
Q
QP
D
-
T
P
P
L
V
W
T
P
F
-----
T
G
G
H
W
I
A
T
R
G
T
L
I
D
E
I
Y
R
S
P
E
R
F
S
S
R
V
I
W
V
-
P
R
E
A
--
G
E
A
Y
D
M
V
P
T
K
L
------
D
P
P
E
H
T
P
Y
R
K
A
I
D
K
G
L
N
L
A
E
I
R
K
L
E
D
Q
I
R
T
I
A
V
E
I
I
E
G
F
A
D
R
-
G
H
-
C
E
F
G
S
E
F
S
T
V
F
P
V
R
V
F
L
A
L
A
G
L
P
V
E
D
A
T
K
L
G
L
L
-
A
N
E
M
T
R
P
S
G
N
T
-
P
E
E
-
Q
G
-
R
S
L
E
A
A
N
K
G
F
F
E
-
Y
V
A
P
I
I
A
A
R
R
G
G
S
G
T
D
L
I
T
---
R
I
L
N
V
---
E
I
---
D
G
K
P
M
P
D
D
R
A
L
G
L
V
S
L
L
L
L
G
G
L
N
T
V
V
N
F
L
G
F
M
M
I
Y
L
S
R
H
P
E
T
V
A
E
M
R
R
E
P
L
K
L
Q
R
G
V
E
E
L
F
R
R
F
A
V
V
S
D
-
A
R
-
Y
V
V
S
D
-
M
E
F
H
G
T
M
L
K
E
G
D
L
I
L
L
P
T
A
L
H
G
L
D
D
R
H
H
D
D
P
M
T
V
D
---
L
S
R
R
D
V
T
H
S
T
F
A
Q
G
P
H
R
C
A
G
M
H
L
A
R
L
E
V
T
V
M
L
Q
E
W
L
A
R
I
P
E
F
R
L
K
-
D
R
A
V
P
I
Y
H
-
S
G
I
V
A
-
A
V
E
---
N
I
P
L
E
W
E
62
PsiBlast_CBE
88.01
31%
-109
- C7 -
3NV5
3
?
A:
[94-448]
------------------------------------------------
F
-----
T
G
G
H
W
I
A
T
N
G
D
T
V
K
E
V
Y
S
D
P
T
R
F
S
S
E
V
I
F
L
-
P
--
K
E--
E
K
Y
Q
M
V
P
T
K
M
------
D
P
P
E
H
T
P
Y
R
K
A
L
D
K
G
L
N
L
A
K
I
R
K
V
E
D
K
V
R
E
V
A
S
S
L
I
D
S
F
A
A
R
-
G
E
-
C
D
F
A
A
E
Y
A
E
L
F
P
V
H
V
F
M
A
L
A
D
L
P
L
E
D
I
P
V
L
S
E
Y
A
R
Q
M
T
R
P
E
-----
P
E
E
-
M
A
-
T
D
L
E
A
G
N
N
G
F
Y
A
-
Y
V
D
P
I
I
R
A
R
V
G
G
D
G
D
D
L
I
T
L
M
V
N
---
S
---
E
I
---
N
G
E
R
I
A
H
D
K
A
Q
G
L
I
S
L
L
L
L
G
G
L
D
T
V
V
N
F
L
S
F
F
M
I
H
L
A
R
H
P
E
L
V
A
E
L
R
S
D
P
L
K
L
M
R
G
A
E
E
M
F
R
R
F
P
V
V
S
E
-
A
--
R
M
V
A
K
D
Q
E
Y
K
G
V
F
L
K
R
G
D
M
I
L
L
P
T
A
L
H
---
G
L
D
D
A
A
N
P
E
P
W
K
L
D
F
S
R
R
S
I
S
H
S
T
F
G
G
G
P
H
R
C
A
G
M
H
L
A
R
M
E
V
I
V
T
L
E
E
W
L
K
R
I
P
E
F
S
F
K
E
G
E
T
P
-
I
Y
H
-
S
G
I
V
A
-
A
V
E
---
N
V
P
L
V
W
-
63
PsiBlast_CBE
87.07
31%
-104
- C7 -
4DXY
6
?
A:
[59-413]
------------------------------------------------
F
-----
T
G
G
H
W
I
A
T
N
G
D
T
V
K
E
V
Y
S
D
P
T
R
F
S
S
E
V
I
F
L
-
P
--
K
EA
G
E
K
A
Q
M
V
P
T
K
M
------
D
P
P
E
H
T
P
Y
R
K
A
L
D
K
G
L
N
L
A
K
I
R
K
V
E
D
K
V
R
E
V
A
S
S
L
I
D
S
F
A
A
R
-
G
E
-
C
D
F
A
A
E
Y
A
E
L
F
P
V
H
V
F
M
A
L
A
D
L
P
L
E
D
I
P
V
L
S
E
Y
A
R
Q
M
T
R
P
E
G
-
N
T
-
P
E
E
-
M
A
-
T
D
L
E
A
G
N
N
G
F
Y
A
-
Y
V
D
P
I
I
R
A
R
V
G
G
D
G
D
D
L
I
T
L
M
V
N
---
S
---
E
I
---
N
G
E
R
I
A
H
D
K
A
Q
G
L
I
S
L
L
L
L
G
G
L
D
T
V
V
N
F
L
S
F
F
M
I
H
L
A
R
H
P
E
L
V
A
E
L
R
S
D
P
L
K
L
M
R
G
A
E
E
M
F
R
R
F
P
V
V
S
E
-
A
--
R
M
V
A
K
D
Q
E
Y
K
G
V
F
L
K
R
G
D
M
I
L
L
P
T
A
L
H
---
G
L
D
D
A
A
N
P
E
P
W
K
L
D
F
S
R
R
S
I
S
H
S
T
F
G
G
G
P
H
R
C
A
G
M
H
L
A
R
M
E
V
I
V
T
L
E
E
W
L
K
R
I
P
E
F
S
F
K
E
G
E
T
P
-
I
Y
H
-
S
G
I
V
A
-
A
V
E
---
N
V
P
L
V
W
-