@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2419c: (2016-05-10 )
MRARRLVMLRHGQTDYNVGSRMQGQLDTELSELGRTQAVAAAEVLGKRQPLLIVSSDLRRAYDTAVKLGERTGLVVRVDTRLRETHLGDWQGLTHAQIDADAPGARLAWREDATWAPHGGESRVDVAARSRPLVAELVASEPEWGGADEPDRPVVLVAHGGLIAALSAALLKLPVANWPALGGMGNASWTQLSGHWAPGSDFESIRWRLDVWNASAQVSSDVL
Atome Classification :
(22 SA)
.........10..-......20..----.-.-....30........40......--.--.---50........60....----....70.---.----.---.---....80........90.....----..-.100..-.-.-...110.-------------------------...---------------------------...-----.120.......130.......140...----------------....150.......160.......170......-------.180-.......190.......200...-..--..210.......220.-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
A
R
R
L
V
M
L
RHGQ-TDYNVGSRMQ----G-
Q
-
L
D
T
E
L
S
ELGR
T
Q
A
V
A
A
A
E
V
LGK--R--Q---
P
L
L
I
V
S
S
D
L
R
R
A
Y
D
T
A
----
V
KLGERT---
G
----
L
---
V
---
V
R
VDT
R
L
R
ETHLGDWQGL
T
H
A
----
Q
I-DADAPG-A-
R
-
L
A
WR-ED-------------------------ATW---------------------------APH-----GGES
R
V
D
V
AARSR
P
L
V
A
E
L
VASEPEWG----------------GADEPDR
P
V
V
L
V
AH
G
G
L
I
A
A
L
S
A
A
L
L
KLPVANW-------PALG-GMGNAS
W
T
QLSGHWAPGSD
F
E
S
I
-
R
W
--
R
L
D
VWNASAQVSSDVL-----
22
PsiBlast_CBE
99.11
100%
-82
- C2 -
4PZA
1
GPGP_MYCTO
B:
[2-218]
-
R
A
R
R
L
V
M
L
R
H
G
Q
-
T
D
Y
N
V
G
S
R
M
Q
----
G
-
Q
-
L
D
T
E
L
S
E
L
G
R
T
Q
A
V
A
A
A
E
V
L
G
K
--
R
--
Q
---
P
L
L
I
V
S
S
D
L
R
R
A
Y
D
T
A
----
V
K
L
G
E
R
T
---
G
----
L
---
V
---
V
R
V
D
T
R
L
R
E
T
H
L
G
D
W
Q
G
L
T
H
A
----
Q
I
-
D
A
D
A
P
G
-
A
-
R
-
L
A
W
R
-
E
D
-------------------------
A
T
W
---------------------------
A
P
H
-----
G
G
E
S
R
V
D
V
A
A
R
S
R
P
L
V
A
E
L
V
A
S
E
P
E
W
G
----------------
G
A
D
E
P
D
R
P
V
V
L
V
A
H
G
G
L
I
A
A
L
S
A
A
L
L
K
L
P
V
A
N
W
-------
P
A
L
G
-
G
M
G
N
A
S
W
T
Q
L
S
G
H
W
A
P
G
S
D
F
E
S
I
-
R
W
--
R
L
D
V
W
N
A
S
A
Q
V
----------
69
HHSearch
95.33
100%
-85
- C2 -
4PZA
1
GPGP_MYCTO
A:
[3-219]
--
A
R
R
L
V
M
L
R
H
G
Q
-
T
D
-----
R
M
Q
----
G
-
Q
-
L
D
T
E
L
S
E
L
G
R
T
Q
A
V
A
A
A
E
V
L
G
K
--
R
--
Q
---
P
L
L
I
V
S
S
D
L
R
R
A
Y
D
T
A
----
V
K
L
G
E
R
T
---
G
----
L
---
V
---
V
R
V
D
T
R
L
R
E
T
H
L
G
D
W
Q
G
L
T
H
A
----
Q
I
-
D
A
D
A
P
G
-
A
-
R
-
L
A
W
R
-
E
D
-------------------------
A
T
W
---------------------------
A
P
H
-----
G
G
E
S
R
V
D
V
A
A
R
S
R
P
L
V
A
E
L
V
A
S
E
P
E
W
G
----------------
G
A
D
E
P
D
R
P
V
V
L
V
A
H
G
G
L
I
A
A
L
S
A
A
L
L
K
L
P
V
A
N
W
-------
P
A
L
G
-
G
M
G
N
A
S
W
T
Q
L
S
G
H
W
-----
F
E
S
I
-
R
W
--
R
L
D
V
W
N
A
S
A
Q
V
S
---------
1
PsiBlast_PDB
95.33
100%
-85
- C2 -
4PZA
1
GPGP_MYCTO
A:
[3-219]
--
A
R
R
L
V
M
L
R
H
G
Q
-
T
D
-----
R
M
Q
----
G
-
Q
-
L
D
T
E
L
S
E
L
G
R
T
Q
A
V
A
A
A
E
V
L
G
K
--
R
--
Q
---
P
L
L
I
V
S
S
D
L
R
R
A
Y
D
T
A
----
V
K
L
G
E
R
T
---
G
----
L
---
V
---
V
R
V
D
T
R
L
R
E
T
H
L
G
D
W
Q
G
L
T
H
A
----
Q
I
-
D
A
D
A
P
G
-
A
-
R
-
L
A
W
R
-
E
D
-------------------------
A
T
W
---------------------------
A
P
H
-----
G
G
E
S
R
V
D
V
A
A
R
S
R
P
L
V
A
E
L
V
A
S
E
P
E
W
G
----------------
G
A
D
E
P
D
R
P
V
V
L
V
A
H
G
G
L
I
A
A
L
S
A
A
L
L
K
L
P
V
A
N
W
-------
P
A
L
G
-
G
M
G
N
A
S
W
T
Q
L
S
G
H
W
-----
F
E
S
I
-
R
W
--
R
L
D
V
W
N
A
S
A
Q
V
S
---------
2
PsiBlast_PDB
93.37
100%
-85
- C2 -
4QIH
1
GPGP_MYCTO
A:
[3-215]
--
A
R
R
L
V
M
L
R
H
G
Q
-
T
D
Y
N
V
G
S
R
M
Q
----
G
-
Q
-
L
D
T
E
L
S
E
L
G
R
T
Q
A
V
A
A
A
E
V
L
G
K
--
R
--
Q
---
P
L
L
I
V
S
S
D
L
R
R
A
Y
D
T
A
----
V
K
L
G
E
R
T
---
G
----
L
---
V
---
V
R
V
D
T
R
L
R
E
T
H
L
G
D
W
Q
G
L
T
H
A
----
Q
I
-
D
A
D
A
P
G
-
A
-
R
-
L
A
W
R
-
E
D
-------------------------
A
T
W
---------------------------
A
P
H
-----
G
G
E
S
R
V
D
V
A
A
R
S
R
P
L
V
A
E
L
V
A
S
E
P
E
W
G
----------------
G
A
D
E
P
D
R
P
V
V
L
V
A
H
G
G
L
I
A
A
L
S
A
A
L
L
K
L
P
V
A
N
W
-------
P
A
L
G
-
G
M
G
N
A
S
W
T
Q
L
S
G
H
W
----
D
F
E
S
I
-
R
W
--
R
L
D
V
W
N
A
S
-------------
21
PsiBlast_CBE
88.32
100%
-80
* C2 *
4QIH
1
GPGP_MYCTO
B:
[3-215]
--
A
R
R
L
V
M
L
R
H
G
Q
-
T
D
Y
N
V
G
S
R
M
Q
----
G
-
Q
-
L
D
T
E
L
S
E
L
G
R
T
Q
A
V
A
A
A
E
V
L
G
K
--
R
--
Q
---
P
L
L
I
V
S
S
D
L
R
R
A
Y
D
T
A
----
V
K
L
G
E
R
T
---
G
----
L
---
V
---
V
R
V
D
T
R
L
R
E
T
H
L
G
D
W
Q
G
L
T
H
A
----
Q
I
-
D
A
D
A
P
G
-
A
-
R
-
L
A
W
R
-
E
D
-------------------------
A
T
W
---------------------------
A
P
H
-----
G
G
E
S
R
V
D
V
A
A
R
S
R
P
L
V
A
E
L
V
A
S
E
P
E
W
--------------------
E
P
D
R
P
V
V
L
V
A
H
G
G
L
I
A
A
L
S
A
A
L
L
K
L
P
V
A
N
W
-------
P
A
L
G
-
G
M
G
N
A
S
W
T
Q
L
S
G
H
--------
S
I
-
R
W
--
R
L
D
V
W
N
A
S
-------------
70
HHSearch
61.90
28%
-58
- C2 -
4IJ5
4
PSPA_HYDTT
A:
[1-203]
--
M
V
K
L
I
L
V
R
H
A
E
-
S
E
W
N
P
V
G
R
Y
Q
----
G
-
L
-
L
D
P
D
L
S
E
R
G
K
K
Q
A
K
L
L
A
Q
E
L
S
R
--
E
--
H
---
L
D
V
I
Y
S
S
P
L
K
R
T
Y
L
T
A
----
L
E
I
A
E
A
K
---
N
----
L
---
E
---
V
I
K
E
D
R
I
I
E
I
D
H
G
M
W
S
G
M
L
V
E
----
E
V
-
M
E
K
Y
P
E
-
D
-
F
-
R
R
W
V
E
E
P
-------------------------
H
K
V
---------------------------
E
F
Q
-----
G
G
E
S
L
A
S
V
Y
N
R
V
K
G
F
L
E
E
V
R
K
R
------------------------
H
W
N
Q
T
V
V
V
V
S
H
T
V
P
M
R
A
M
Y
C
A
L
L
G
V
D
L
S
K
F
-------
W
S
-
F
-
G
C
D
N
A
S
Y
S
V
I
H
M
E
E
--------
R
-
R
N
--
V
I
L
K
L
N
I
T
C
H
L
G
E
F
-------
71
HHSearch
61.09
31%
-66
- C2 -
1H2E
3
?
A:
[1-203]
--
A
T
T
L
Y
L
T
R
H
G
E
-
T
K
W
N
V
E
R
R
M
Q
----
G
-
W
-
Q
D
S
P
L
T
E
K
G
R
Q
D
A
M
R
L
G
K
R
L
E
A
--
V
--
E
---
L
A
A
I
Y
T
S
T
S
G
R
A
L
E
T
A
----
E
I
V
R
G
G
R
---
L
----
I
---
P
---
I
Y
Q
D
E
R
L
R
E
I
H
L
G
D
W
E
G
K
T
H
D
----
E
I
-
R
Q
M
D
P
I
-
A
-
F
-
D
H
F
W
Q
A
P
-------------------------
H
L
Y
---------------------------
A
P
Q
-----
R
G
E
R
F
C
D
V
Q
Q
R
A
L
E
A
V
Q
S
I
V
D
R
------------------------
H
E
G
E
T
V
L
I
V
T
H
G
V
V
L
K
T
L
M
A
A
F
K
D
T
P
L
D
H
L
-------
W
S
P
P
-
Y
M
Y
G
T
S
V
T
I
I
E
V
D
G
--------
G
-
T
F
--
H
V
A
V
E
G
D
V
S
H
I
E
E
--------
76
HHSearch
60.67
20%
-60
- C2 -
2YN2
1
YNK8_YEAST
A:
[11-246]
-
A
I
E
N
I
Y
I
A
R
H
G
Y
R
S
N
W
L
P
K
G
P
Y
P
PPPT
G
I
D
-
N
D
V
P
L
S
E
H
G
V
E
Q
A
H
E
L
A
N
Y
I
S
K
LD
V
--
K
---
P
E
M
I
F
S
S
P
F
Y
R
C
L
E
T
S
----
K
P
T
V
E
A
L
---
K
----
I
---
P
---
L
Y
V
D
R
G
V
G
E
W
Y
K
P
D
R
P
I
I
P
E
P
A
T
H
E
V
M
-
S
K
F
F
P
S
-
M
-
I
S
P
D
W
E
--
P
-------------------------
S
I
I
---------------------------
P
S
N
-----
K
G
E
T
E
E
D
I
F
E
R
C
H
K
F
W
P
V
F
I
D
R
V
E
R
K
-------------------
F
P
N
V
K
T
I
M
I
V
T
H
A
A
T
K
S
A
L
G
M
N
L
L
K
F
S
S
A
K
E
PIDNK--
G
T
F
I
-
R
N
G
S
C
A
I
D
K
F
E
L
------
P
F
E
E
R
-
E
W
--
K
L
T
M
N
G
N
T
S
F
L
T
N
G
-------
91
HHSearch
60.04
28%
-56
- C2 -
4EO9
1
GPMA_MYCLB
A:
[26-249]
-
N
T
A
T
L
I
L
L
R
H
G
E
-
S
D
W
N
A
R
N
L
F
T
----
G
-
W
-
V
D
V
G
L
T
D
K
G
R
A
E
A
V
R
S
G
E
L
L
A
E
H
N
L
--
L
---
P
D
V
L
Y
T
S
L
L
R
R
A
I
T
T
A
----
H
L
A
L
D
T
A
---
D
WLW-
I
---
P
---
V
R
R
S
W
R
L
N
E
R
H
Y
G
A
L
Q
G
L
D
K
A
----
V
T
-
K
A
R
Y
G
E
-
E
R
F
-
M
A
W
R
-
R
S
YDTPPPPIEKGSEFSQDAD------
P
R
Y
TDIG-----------------------
G
G
P
-----
L
T
E
C
L
A
D
V
V
T
R
F
L
P
Y
F
T
D
V
I
V
P
D
L
----------------------
R
T
G
R
T
V
L
I
V
A
H
G
N
S
L
R
A
L
V
K
H
L
D
E
M
S
D
D
E
V
-------
V
G
-
L
-
N
V
P
T
G
I
P
L
R
Y
D
L
D
A
D
-------
L
-
R
P
--
V
V
P
------------------
10
PsiBlast_PDB
59.53
33%
-83
- C2 -
2A6P
2
?
A:
[9-170]
-
R
N
H
R
L
L
L
L
R
H
G
E
-
T
A
W
S
T
L
G
R
H
T
----
G
-
G
-
T
E
V
E
L
T
D
T
G
R
T
Q
A
E
L
A
G
Q
L
L
G
E
--
L
--
E
LDD
P
I
V
I
C
S
P
R
-
R
R
T
L
D
T
A
K
L
A
G
L
T
V
N
E
V
T
---
G
----
L
---
L
---
A
E
W
D
-------
Y
G
S
Y
E
G
L
T
T
P
----
Q
I
-
R
E
S
E
P
D
---
W
-
L
V
W
------------------------------
T
H
---------------------------
G
C
P
-----
A
G
E
S
V
A
Q
V
N
D
R
A
D
S
A
V
A
--
L
A
L
E
----------------------
H
M
S
S
R
D
V
L
F
V
S
H
G
H
F
S
R
A
V
I
T
R
W
V
Q
L
P
L
A
E
--------------------------------------------------------------
23
PsiBlast_CBE
59.43
33%
-84
- C2 -
2A6P
2
?
B:
[9-170]
-
R
N
H
R
L
L
L
L
R
H
G
E
-
T
A
W
S
T
L
G
R
H
T
----
G
-
G
-
T
E
V
E
L
T
D
T
G
R
T
Q
A
E
L
A
G
Q
L
L
G
E
--
L
--
E
LDD
P
I
V
I
C
S
P
R
-
R
R
T
L
D
T
A
KLAG
L
T
V
N
E
V
T
---
G
----
L
---
L
---
A
E
W
D
-------
Y
G
S
Y
E
G
L
T
T
P
----
Q
I
-
R
E
S
E
P
D
---
W
-
L
V
W
------------------------------
T
H
---------------------------
G
C
P
-----
A
G
E
S
V
A
Q
V
N
D
R
A
D
S
A
V
A
--
L
A
L
E
----------------------
H
M
S
S
R
D
V
L
F
V
S
H
G
H
F
S
R
A
V
I
T
R
W
V
Q
L
P
L
A
E
--------------------------------------------------------------
75
HHSearch
59.01
31%
-61
- C2 -
2A6P
2
?
A:
[9-201]
-
R
N
H
R
L
L
L
L
R
H
G
E
-
T
A
W
S
T
L
G
R
H
T
----
G
-
G
-
T
E
V
E
L
T
D
T
G
R
T
Q
A
E
L
A
G
Q
L
L
G
E
LE
L
--
D
---
D
P
I
V
I
C
S
P
R
R
R
T
L
D
T
A
----
K
L
A
G
L
T
-------------
V
---
N
E
V
T
G
L
L
A
E
W
D
Y
G
S
Y
E
G
L
T
T
P
----
Q
I
-
R
E
S
E
P
D
-------
W
L
--
V
-------------------------
W
T
H
---------------------------
G
C
P
-----
A
G
E
S
V
A
Q
V
N
D
R
A
D
S
A
V
A
L
A
L
E
H
------------------------
M
S
S
R
D
V
L
F
V
S
H
G
H
F
S
R
A
V
I
T
R
W
V
Q
L
P
L
A
E
G
-------
S
R
-
F
-
A
M
P
T
A
S
I
G
I
C
G
F
E
H
--------
G
-
V
R
--
Q
L
A
V
L
G
L
T
G
H
-----------
6
PsiBlast_PDB
58.84
30%
-63
- C2 -
4IJ5
4
PSPA_HYDTT
A:
[3-180]
----
K
L
I
L
V
R
H
A
E
-
S
E
W
N
P
V
G
R
Y
Q
----
G
-
L
-
L
D
P
D
L
S
E
R
G
K
K
Q
A
K
L
L
A
Q
E
L
S
R
--
E
--
H
---
L
D
V
I
Y
S
S
P
L
K
R
T
Y
L
T
A
----
L
E
I
A
E
A
K
---
N
----
L
---
E
---
V
I
K
E
D
R
I
I
E
I
D
H
G
M
W
S
G
M
L
V
E
----
E
V
-
M
E
K
Y
P
E
-
D
-
F
-
R
R
W
V
-
E
E
--------------------------------------------------------
P
H
KVEFQ
G
G
E
S
L
A
S
V
Y
N
R
V
K
G
F
L
E
E
V
--
R
K
R
H
W
----------------------
N
Q
T
V
V
V
V
S
H
T
V
P
M
R
A
M
Y
C
A
L
L
G
V
D
L
S
K
F
-------
W
S
F
G
-
C
-
D
N
A
S
Y
S
-----------------------------------------
94
Fugue
57.55
25%
-54
- C2 -
1QHF
3
PMG1_YEAST
A:
[1-240]
---
P
K
L
V
L
V
R
H
G
Q
-
S
E
W
N
E
K
N
L
F
T
----
G
-
W
-
V
D
V
K
L
S
A
K
G
Q
Q
E
A
A
R
A
G
E
L
L
K
E
--
K
KV
Y
---
P
D
V
L
Y
T
S
K
L
S
R
A
I
Q
T
A
----
N
I
A
L
E
K
A
---
D
----
R
---
L
W
I
P
V
N
R
S
W
R
L
N
E
R
H
Y
G
D
L
Q
G
K
D
K
A
----
E
T
-
L
K
K
F
G
E
-
E
-
K
-
F
N
T
Y
-
R
--------------------------
R
S
F
DVPPPPIDASSPFSQKGDERYKYVDPN
V
L
P
-----
E
T
E
S
L
A
L
V
I
D
R
L
L
P
Y
W
Q
D
V
I
A
K
D
L
L
S
G
----------------------
K
T
V
M
I
A
A
H
G
N
S
L
R
G
L
V
K
H
L
E
G
I
S
D
A
D
I
-------
A
K
L
N
I
P
T
G
I
P
L
V
F
E
L
D
E
N
L
K
P
S
K
P
S
Y
Y
L
-
D
P
--
E
A
A
A
A
-----------GAAAV
74
HHSearch
55.58
26%
-51
- C2 -
3DCY
1
TIGAR_HUMAN
A:
[7-269]
-
A
R
F
A
L
T
V
V
R
H
G
E
-
T
R
F
N
K
E
K
I
I
Q
----
G
-
Q
G
V
D
E
P
L
S
E
T
G
F
K
Q
A
A
A
A
G
I
F
L
N
N
--
V
--
K
---
F
T
H
A
F
S
S
D
L
M
R
T
K
Q
T
M
----
H
G
I
L
E
R
S
---
K
FCKD
M
---
T
---
V
K
Y
D
S
R
L
R
E
R
K
Y
G
V
V
E
G
K
A
L
S
----
E
L
-
R
A
M
A
K
A
-------
A
R
E
E
C
-------------------------
P
V
F
---------------------------
T
P
P
-----
G
G
E
T
L
D
Q
V
K
M
R
G
I
D
F
F
E
F
L
C
Q
L
I
L
K
E
A
D
Q
KN
C
L
E
T
S
L
A
E
I
FPL-
I
P
G
L
A
A
S
V
L
V
V
S
H
G
A
Y
M
R
S
L
F
D
Y
F
L
T
D
L
K
C
S
L
P
ATLS
R
S
E
L
M
S
-
V
T
P
N
T
G
M
S
L
F
I
I
N
F
E
E
G
---
R
E
V
-
K
P
T
V
Q
C
I
C
M
N
L
Q
D
H
L
N
---------
86
HHSearch
55.03
24%
-56
- C2 -
3KKK
-
?
A:
[2-231]
-
T
T
Y
T
L
V
L
L
R
H
G
E
-
S
T
W
N
K
E
N
K
F
T
----
G
-
W
-
T
D
V
P
L
S
E
K
G
E
E
E
A
I
A
A
G
K
Y
L
K
E
K
N
F
--
K
---
F
D
V
V
Y
T
S
V
L
K
R
A
I
C
T
A
----
W
N
V
L
K
T
A
DLL
H
----
V
---
P
---
V
V
K
T
W
R
L
N
E
R
H
C
G
S
L
Q
G
L
N
K
S
----
E
T
-
A
K
K
Y
G
E
-
E
Q
V
-
K
I
W
R
-
R
S
YDIP
P
P
K
L
D
KEDNRWPGHNVVYKNV
P
K
D
---------------------------
A
L
P
-----
F
T
E
C
L
K
D
T
V
E
R
V
L
P
F
W
F
D
H
I
A
P
D
I
----------------------
L
A
N
K
K
V
M
V
A
A
H
G
N
S
L
R
G
L
V
K
H
L
D
N
L
S
E
A
D
V
-------
L
E
-
L
-
N
I
P
T
G
V
P
L
V
Y
E
L
D
E
N
-------
L
-
K
P
--
I
K
H
Y
Y
L
L
--------------
3
PsiBlast_PDB
54.84
33%
-66
- C2 -
1EBB
8
?
A:
[1-166]
--
A
T
T
L
Y
L
T
R
H
G
E
-
T
K
W
N
V
E
R
R
M
Q
----
G
-
W
-
Q
D
S
P
L
T
E
K
G
R
Q
D
A
M
R
L
G
K
R
L
E
A
--
V
--
E
---
L
A
A
I
Y
T
S
T
S
G
R
A
L
E
T
A
----
E
I
V
R
G
G
R
---
L
----
I
---
P
---
I
Y
Q
D
E
R
L
R
E
I
H
L
G
D
W
E
G
K
T
H
D
----
E
I
-
R
Q
M
D
P
I
-
A
-
F
D
H
F
W
Q
-
A
P
-------------------------
H
L
Y
---------------------------
A
P
Q
-----
R
G
E
R
F
C
D
V
Q
Q
R
A
L
E
A
V
Q
S
I
V
D
R
------------------------
H
E
G
E
T
V
L
I
V
T
H
G
V
V
L
K
T
L
M
A
A
F
K
D
T
P
L
----------------------------------------------------------------
84
HHSearch
54.56
24%
-51
- C2 -
4EMB
1
GPMA_BORBU
A:
[26-263]
-
F
M
Y
K
L
V
L
V
R
H
G
E
-
S
E
W
N
K
E
N
L
F
T
----
G
-
W
-
T
D
V
K
L
S
D
K
G
I
D
E
A
V
E
A
G
L
L
L
K
Q
E
G
Y
--
S
---
F
D
I
A
F
S
S
L
L
S
R
A
N
D
T
L
----
N
I
I
L
R
E
L
---
G
----
Q
SY
I
S
---
V
K
K
T
W
R
L
N
E
R
H
Y
G
A
L
Q
G
L
N
K
S
----
E
T
-
A
A
K
Y
G
E
-
D
K
V
-
L
I
W
R
-
R
S
YDVP
P
M
S
L
D
ESDDRHPIKDPRYKHI
P
K
R
---------------------------
E
L
P
-----
S
T
E
C
L
K
D
T
V
A
R
V
I
P
Y
W
T
D
E
I
A
K
E
V
----------------------
L
E
G
K
K
V
I
V
A
A
H
G
N
S
L
R
A
L
V
K
Y
F
D
N
L
S
E
E
D
V
-------
L
K
-
L
-
N
I
P
T
G
I
P
L
V
Y
E
L
D
K
D
-------
L
N
P
I
--
K
H
Y
Y
L
G
D
E
S
K
I
K
K
A
-------
92
HHSearch
54.48
23%
-57
- C2 -
3D8H
-
?
A:
[20-248]
--
T
Y
K
L
T
L
I
R
H
G
E
-
S
E
W
N
K
E
N
R
F
T
----
G
-
W
-
T
D
V
S
L
S
E
Q
G
V
S
E
A
I
E
A
G
R
M
L
L
E
K
G
F
--
K
---
F
D
V
V
Y
T
S
V
L
K
R
A
I
M
T
T
----
W
T
V
L
K
E
L
---
G
NIN-
C
---
P
---
I
I
N
H
W
R
L
N
E
R
H
Y
G
A
L
Q
G
L
N
K
S
----
E
T
-
A
S
K
F
G
E
-
D
Q
V
-
K
I
W
R
-
R
S
FDVP
P
P
V
L
E
KSDPRWPGNELIYKGI
C
P
S
---------------------------
C
L
P
-----
T
T
E
C
L
K
D
T
V
E
R
V
K
P
Y
F
E
D
V
I
A
P
S
I
----------------------
M
S
G
K
S
V
L
V
S
A
H
G
N
S
L
R
A
L
L
Y
L
L
E
G
M
T
P
E
Q
I
-------
L
E
-
V
-
N
I
P
T
A
C
P
L
V
L
E
L
D
D
Y
-------
L
-
K
V
--
T
K
K
Y
Y
L
I
--------------
80
HHSearch
54.04
25%
-52
- C2 -
1FZT
-
PMGY_SCHPO
A:
[6-210]
-
A
P
N
L
L
V
L
T
R
H
G
E
-
S
E
W
N
K
L
N
L
F
T
----
G
-
W
-
K
D
P
A
L
S
E
T
G
I
K
E
A
K
L
G
G
E
R
L
K
S
R
G
Y
--
K
---
F
D
I
A
F
T
S
A
L
Q
R
A
Q
K
T
C
----
Q
I
I
L
E
E
V
---
G
EPN-
L
---
E
---
T
I
K
S
E
K
L
N
E
R
Y
Y
G
D
L
Q
G
L
N
K
D
----
D
A
-
R
K
K
W
G
A
E
Q
-
V
-
Q
I
W
R
-
R
S
-------------------------
Y
D
I
---------------------------
A
P
P
-----
N
G
E
S
L
K
D
T
A
E
R
V
L
P
Y
Y
K
S
T
I
V
P
H
I
----------------------
L
K
G
E
K
V
L
I
A
A
H
G
N
S
L
R
A
L
I
M
D
L
E
G
L
T
G
D
Q
I
-------
V
K
-
R
-
E
L
A
T
G
V
P
I
V
Y
H
L
D
K
D
-------
G
-
K
Y
--
V
S
K
E
L
I
D
--------------
4
PsiBlast_PDB
52.18
33%
-64
- C2 -
1H2E
3
?
A:
[1-166]
--
A
T
T
L
Y
L
T
R
H
G
E
-
T
K
W
N
V
E
R
R
M
Q
----
G
-
W
-
Q
D
S
P
L
T
E
K
G
R
Q
D
A
M
R
L
G
K
R
L
E
A
--
V
--
E
---
L
A
A
I
Y
T
S
T
S
G
R
A
L
E
T
A
----
E
I
V
R
G
G
R
---
L
----
I
---
P
---
I
Y
Q
D
E
R
L
R
E
I
H
L
G
D
W
E
G
K
T
H
D
----
E
I
R
Q
M
D
P
I
A
-
F
-
D
-
H
F
W
Q
-
A
P
-------------------------
H
L
Y
---------------------------
A
P
Q
-----
R
G
E
R
F
C
D
V
Q
Q
R
A
L
E
A
V
Q
S
I
V
D
R
------------------------
H
E
G
E
T
V
L
I
V
T
H
G
V
V
L
K
T
L
M
A
A
F
K
D
T
P
L
----------------------------------------------------------------
5
PsiBlast_PDB
51.55
33%
-63
- C2 -
1H2F
2
?
A:
[1-166]
--
A
T
T
L
Y
L
T
R
H
G
E
-
T
K
W
N
V
E
R
R
M
Q
----
G
-
W
-
Q
D
S
P
L
T
E
K
G
R
Q
D
A
M
R
L
G
K
R
L
E
A
--
V
--
E
---
L
A
A
I
Y
T
S
T
S
G
R
A
L
E
T
A
----
E
I
V
R
G
G
R
---
L
----
I
---
P
---
I
Y
Q
D
E
R
L
R
E
I
H
L
G
D
W
E
G
K
T
H
D
----
E
I
R
Q
M
D
P
I
A
-
F
-
D
-
H
F
W
Q
-
A
P
-------------------------
H
L
Y
---------------------------
A
P
Q
-----
R
G
E
R
F
C
D
V
Q
Q
R
A
L
E
A
V
Q
S
I
V
D
R
------------------------
H
E
G
E
T
V
L
I
V
T
H
G
V
V
L
K
T
L
M
A
A
F
K
D
T
P
L
----------------------------------------------------------------