@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2971: (2016-05-15 )
MTGESGAAAAPSITLNDEHTMPVLGLGVAELSDDETERAVSAALEIGCRLIDTAYAYGNEAAVGRAIAASGVAREELFVTTKLATPDQGFTRSQEACRASLDRLGLDYVDLYLIHWPAPPVGKYVDAWGGMIQSRGEGHARSIGVSNFTAENIENLIDLTFVTPAVNQIELHPLLNQDELRKANAQHTVVTQSYCPLALGRLLDNPTVTSIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIASNFDVFDFELAAEHMDALGGLNDGTRVREDPLTYAGT
Atome Classification :
(84 SA)
.........10.....-....20.......---.---30.-.-----.-.-....40........50.......---.60...----...----..----70----.........80........90........100.......110.....---------.----------.-----------120------------.------.---------.----------.------.-----...130.......140.......150......---.160........170.....--..180.......190......-------.200-----.-----------.--.-------.---.....210.......220.......230........240.......250.......260.....--.-.270.......280
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTGESGAAAA-
P
S
I
T
L-NDEHTM
P
V
L
G
LGV---A---ELS-
D
-----
D
-
E
-
T
E
R
A
V
S
A
A
L
E
I
G
C
R
L
I
D
T
A
Y
AYG---NEAAVG----
R
A
I
----
A
A----S-----GVAR
E
E
L
F
V
T
T
KLATPDQGFT
R
S
Q
E
A
C
R
A
S
L
D
R
L
G
L
D
Y
V
D
L
Y
L
I
HWP---------A----------P-----------P
V
-------------
G
------
K
---------
Y
----------
V
------
D
-----
A
W
G
G
M
I
QSRGEGHARSIGVSNF
T
A
E
N
I
E
N
L
I
D
---
L
T
-FVTPAV
N
Q
I
E
LHPLL
N
Q
--
D
E
L
R
KANAQ
H
T
V
V
TQSY
C
P
L
A
-------
L
G
-------
R
-----------L--L-------D---NP
T
V
T
S
I
A
S
E
Y
VK
T
P
A
Q
V
L
L
R
W
NLQL-G
N
A
V
V
V
RSA
R
P
E
R
I
ASNFDV
F
D
F
E
L
A
A
E
H
M
D
A
LGGLN--D-GTRVREDPLTYAGT
1
PsiBlast_PDB
99.29
99%
-96
- C6 -
4OTK
3
Y2971_MYCTU
A:
[43-318]
------
A
A
A
A
-
P
S
I
T
L
-
N
D
E
H
T
M
P
V
L
G
L
G
V
---
A
---
E
L
S
-
D
-----
D
-
E
-
T
E
R
A
V
S
A
A
L
E
I
G
C
R
L
I
D
T
A
Y
A
Y
G
---
N
E
A
A
V
G
----
R
A
I
----
A
A
----
S
-----
G
V
A
R
E
E
L
F
V
T
T
K
L
A
T
P
D
Q
G
F
T
R
S
Q
E
A
C
R
A
S
L
D
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
---------
A
----------
P
-----------
P
V
-------------
G
------
K
---------
Y
----------
V
------
D
-----
A
W
G
G
M
I
Q
S
R
G
E
G
H
A
R
S
I
G
V
S
N
F
T
A
E
N
I
E
N
L
I
D
---
L
T
-
F
V
T
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
--
D
E
L
R
K
A
N
A
Q
H
T
V
V
T
Q
S
Y
C
P
L
A
-------
L
G
-------
R
-----------
L
--
L
-------
D
---
N
P
T
V
T
S
I
A
S
E
Y
V
K
T
P
A
Q
V
L
L
R
W
N
L
Q
L
-
G
N
A
V
V
V
R
S
A
R
P
E
R
I
A
S
N
F
D
V
F
D
F
E
L
A
A
E
H
M
D
A
L
G
G
L
N
--
D
-
G
T
R
V
R
E
D
P
L
T
Y
A
G
T
111
HHSearch
97.75
98%
-95
- C6 -
4OTK
3
Y2971_MYCTU
A:
[43-318]
------
A
A
A
A
-
P
S
I
T
L
-
N
D
E
H
T
M
P
V
L
G
L
G
V
---
A
---
E
L
S
-
D
-----
D
-
E
-
T
E
R
A
V
S
A
A
L
E
I
G
C
R
L
I
D
T
A
Y
A
Y
G
---
N
E
A
A
V
G
----
R
A
I
----
A
A
----
S
-----
G
V
A
R
E
E
L
F
V
T
T
K
L
A
T
P
D
Q
G
F
T
R
S
Q
E
A
C
R
A
S
L
D
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
---------
A
----------
P
-----------
P
V
-------------
G
------
K
---------
Y
----------
V
------
D
-----
A
W
G
G
M
I
Q
S
R
G
E
G
H
A
R
S
I
G
V
S
N
F
T
A
E
N
I
E
N
L
I
D
---
L
T
-
F
V
T
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
--
D
E
L
R
K
A
N
A
Q
H
T
V
V
T
Q
S
Y
C
P
L
A
-------
L
G
-------
R
-----------
L
--
L
-------
D
---
N
P
T
V
T
S
I
A
S
E
Y
V
K
T
P
A
Q
V
L
L
R
W
N
L
Q
L
-
G
N
A
V
V
V
R
S
A
R
P
E
R
I
A
S
N
F
D
V
F
D
F
E
L
A
A
E
H
M
D
A
L
G
G
L
N
--
D
G
T
R
V
R
E
-
D
P
L
T
Y
A
G
T
2
PsiBlast_PDB
83.90
66%
-87
- C6 -
2WZM
1
Y2407_MYCS2
A:
[10-283]
---------
A
I
P
T
V
T
L
-
N
D
D
N
T
L
P
V
V
G
I
G
V
---
G
---
E
L
S
-
D
-----
S
-
E
-
A
E
R
S
V
S
A
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
---
N
E
A
A
V
G
----
R
A
I
----
A
A
----
S
-----
G
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
---------
G
----------
G
-----------
D
T
-------------
S
------
K
---------
Y
----------
V
------
D
-----
S
W
G
G
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
G
A
E
D
L
E
T
I
V
S
---
L
T
-
Y
F
T
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
--
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
G
-------
V
G
-------
R
-----------
L
--
L
-------
D
---
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
-
G
N
V
V
I
S
R
S
A
N
P
E
R
I
A
S
N
L
D
V
F
G
F
E
L
T
A
D
E
M
E
T
L
N
G
L
D
--
D
-
G
T
R
F
R
P
D
P
A
T
Y
T
G
S
21
PsiBlast_CBE
83.88
66%
-88
- C6 -
2WZM
1
Y2407_MYCS2
B:
[10-283]
---------
A
I
P
T
V
T
L
-
N
D
D
N
T
L
P
V
V
G
I
G
V
---
G
---
E
L
S
-
D
-----
S
-
E
-
A
E
R
S
V
S
A
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
---
N
E
A
A
V
G
----
R
A
I
----
A
A
----
S
-----
G
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
---------
G
----------
G
-----------
D
T
-------------
S
------
K
---------
Y
----------
V
------
D
-----
S
W
G
G
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
G
A
E
D
L
E
T
I
V
S
---
L
T
-
Y
F
T
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
--
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
G
-------
V
G
-------
R
-----------
L
--
L
-------
D
---
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
-
G
N
V
V
I
S
R
S
A
N
P
E
R
I
A
S
N
L
D
V
F
G
F
E
L
T
A
D
E
M
E
T
L
N
G
L
D
--
D
-
G
T
R
F
R
P
D
P
A
T
Y
T
G
S
112
HHSearch
83.83
66%
-86
- C6 -
2WZM
1
Y2407_MYCS2
A:
[10-283]
--------
A
I
-
P
T
V
T
L
-
N
D
D
N
T
L
P
V
V
G
I
G
V
---
G
---
E
L
S
-
D
-----
S
-
E
-
A
E
R
S
V
S
A
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
---
N
E
A
A
V
G
----
R
A
I
----
A
A
----
S
-----
G
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
---------
G
----------
G
-----------
D
T
-------------
S
------
K
---------
Y
----------
V
------
D
-----
S
W
G
G
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
G
A
E
D
L
E
T
I
V
S
---
L
T
-
Y
F
T
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
--
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
G
-------
V
G
-------
R
-----------
L
--
L
-------
D
---
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
-
G
N
V
V
I
S
R
S
A
N
P
E
R
I
A
S
N
L
D
V
F
G
F
E
L
T
A
D
E
M
E
T
L
N
G
L
D
--
D
G
T
R
F
R
-
P
D
P
A
T
Y
T
G
S
3
PsiBlast_PDB
83.17
66%
-98
- C6 -
2WZT
-
Y2407_MYCS2
A:
[10-269]
---------
A
I
P
T
V
T
L
-
N
D
D
N
T
L
P
V
V
G
I
G
V
---
G
---
E
L
S
-
D
-----
S
-
E
-
A
E
R
S
V
S
A
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
---
N
E
A
A
V
G
----
R
A
I
----
A
A
----
S
-----
G
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
---------
G
----------
G
-----------
D
T
-------------
S
------
K
---------
Y
----------
V
------
D
-----
S
W
G
G
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
G
A
E
D
L
E
T
I
V
S
---
L
T
-
Y
F
T
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
--
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
G
-------
V
G
-------
R
-----------
L
--
L
-------
D
---
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
-
G
N
V
V
I
S
R
S
A
N
P
E
R
I
A
S
N
L
D
V
F
G
F
E
L
T
A
D
E
M
E
T
L
N
G
L
D
--
D
---------------
5
PsiBlast_PDB
79.83
46%
-90
- C6 -
1MZR
4
DKGA_ECOLI
A:
[23-296]
-------
A
N
P
-
T
V
I
K
L
-
Q
D
G
N
V
M
P
Q
L
G
L
G
V
---
W
---
Q
A
S
-
N
-----
E
-
E
-
V
I
T
A
I
Q
K
A
L
E
V
G
Y
R
S
I
D
T
A
A
A
Y
K
---
N
E
E
G
V
G
----
K
A
L
----
K
N
----
A
-----
S
V
N
R
E
E
L
F
I
T
T
K
L
W
N
D
D
H
--
K
R
P
R
E
A
L
L
D
S
L
K
K
L
Q
L
D
Y
I
D
L
Y
L
M
H
W
P
---------
V
----------
P
-----------
A
I
-------------
D
------
H
---------
Y
----------
V
------
E
-----
A
W
K
G
M
I
E
L
Q
K
E
G
L
I
K
S
I
G
V
C
N
F
Q
I
H
H
L
Q
R
L
I
D
---
E
T
-
G
V
T
P
V
I
N
Q
I
E
L
H
P
L
M
Q
Q
--
R
Q
L
H
A
W
N
A
T
H
K
I
Q
T
E
S
W
S
P
L
A
-------
Q
G
GK-----
G
-----------
V
--
F
-------
D
---
Q
K
V
I
R
D
L
A
D
K
Y
G
K
T
P
A
Q
I
V
I
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W
H
L
D
S
-
G
L
V
V
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K
S
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T
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R
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A
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N
F
D
V
W
D
F
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L
D
K
D
E
L
G
E
I
A
K
L
D
--
Q
-
G
K
R
L
G
P
D
P
D
Q
F
G
G
-
25
PsiBlast_CBE
79.75
46%
-89
- C6 -
1MZR
3
DKGA_ECOLI
B:
[21-296]
-----
G
L
A
N
P
-
T
V
I
K
L
-
Q
D
G
N
V
M
P
Q
L
G
L
G
V
---
W
---
Q
A
S
-
N
-----
E
-
E
-
V
I
T
A
I
Q
K
A
L
E
V
G
Y
R
S
I
D
T
A
A
A
Y
K
---
N
E
E
G
V
G
----
K
A
L
----
K
N
----
A
-----
S
V
N
R
E
E
L
F
I
T
T
K
L
W
N
D
D
H
--
K
R
P
R
E
A
L
L
D
S
L
K
K
L
Q
L
D
Y
I
D
L
Y
L
M
H
W
P
---------
V
----------
P
-----------
A
I
-------------
D
------
H
---------
Y
----------
V
------
E
-----
A
W
K
G
M
I
E
L
Q
K
E
G
L
I
K
S
I
G
V
C
N
F
Q
I
H
H
L
Q
R
L
I
D
---
E
T
-
G
V
T
P
V
I
N
Q
I
E
L
H
P
L
M
Q
Q
--
R
Q
L
H
A
W
N
A
T
H
K
I
Q
T
E
S
W
S
P
L
A
-------
Q
G
GK-----
G
-----------
V
--
F
-------
D
---
Q
K
V
I
R
D
L
A
D
K
Y
G
K
T
P
A
Q
I
V
I
R
W
H
L
D
S
-
G
L
V
V
I
P
K
S
V
T
P
S
R
I
A
E
N
F
D
V
W
D
F
R
L
D
K
D
E
L
G
E
I
A
K
L
D
--
Q
-
G
K
R
L
G
P
D
P
D
Q
F
G
G
-
27
PsiBlast_CBE
79.55
42%
-90
- C6 -
3WBX
3
?
B:
[12-279]
-------
E
A
Q
-
T
V
I
S
F
-
H
D
G
H
T
M
P
Q
I
G
L
G
V
---
W
---
E
T
P
-
P
-----
D
-
E
-
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
---
N
E
E
G
V
G
----
K
G
L
----
E
D
-------------
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
---------
M
----------
P
-----------
A
Q
-------------
G
------
Q
---------
Y
----------
V
------
E
-----
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
---
A
T
-
G
V
V
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
--
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
-------
K
G
-------
R
-----------
V
--
L
-------
S
---
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
RK
D
-
G
-
R
M
G
A
D
P
N
T
----
113
HHSearch
79.50
48%
-96
- C6 -
3O0K
4
?
A:
[23-282]
------
I
M
T
V
-
P
T
V
K
L
-
N
D
G
N
H
I
P
Q
L
G
Y
G
V
---
W
---
Q
I
S
-
N
-----
D
-
E
-
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
---
N
E
E
G
V
G
----
K
A
I
----
N
G
----
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
---------
M
----------
P
-----------
S
K
-------------
D
------
L
---------
F
----------
M
------
E
-----
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
---
E
S
-
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
--
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
-------
Q
G
-------------------
L
--
L
-------
E
---
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
-------------------
12
PsiBlast_PDB
79.33
42%
-88
- C6 -
4FZI
1
PGFS_TRYCC
A:
[16-284]
-------------
V
T
L
-
H
N
S
V
R
M
P
Q
L
G
L
G
V
---
W
---
R
A
Q
-
D
-----
G
A
E
-
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
---
N
E
R
G
V
G
----
Q
G
I
----
R
E
----
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
---------
G
----------
K
-----------
K
---------------------
K
---------
F
----------
V
------
D
-----
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
---
S
C
-
K
I
R
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
--
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
-------
S
G
-------
E
EAG--------
I
--
L
-------
K
---
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
-
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
--
E
-
D
K
R
I
G
A
D
P
D
N
F
---
29
PsiBlast_CBE
79.21
43%
-93
- C6 -
4G5D
1
PGFS_LEIMA
B:
[13-283]
-------------
V
T
L
-
S
N
G
V
K
M
P
Q
F
G
L
G
V
---
W
---
Q
S
P
-
A
-----
G
-
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
---
N
E
E
S
V
G
----
A
G
L
----
R
A
----
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
RG
K
D
I
L
---
S
----------
K
-----------
E
G
-------------
K
------
K
---------
Y
----------
L
------
D
-----
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
---
M
C
-
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
--
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
-------
Q
G
-------
K
-----------
L
--
L
-------
S
---
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
-
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
--
T
-
N
S
R
Y
G
P
D
P
------
10
PsiBlast_PDB
79.04
43%
-94
- C6 -
4G5D
1
PGFS_LEIMA
A:
[13-283]
-------------
V
T
L
-
S
N
G
V
K
M
P
Q
F
G
L
G
V
---
W
---
Q
S
P
-
A
-----
G
-
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
---
N
E
E
S
V
G
----
A
G
L
----
R
A
----
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
RG
K
D
I
L
---
S
----------
K
-----------
E
G
-------------
K
------
K
---------
Y
----------
L
------
D
-----
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
---
M
C
-
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
--
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
-------
Q
G
-------
K
-----------
L
--
L
-------
S
---
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
-
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
--
T
-
N
S
R
Y
G
P
D
P
------
28
PsiBlast_CBE
78.92
42%
-92
- C6 -
3WBW
3
?
B:
[12-279]
-------
E
A
Q
-
T
V
I
S
F
-
H
D
G
H
T
M
P
Q
I
G
L
G
V
---
W
---
E
T
P
-
P
-----
D
-
E
-
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
---
N
E
E
G
V
G
----
K
G
L
----
E
D
-------------
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
---------
M
----------
P
-----------
A
Q
-------------
G
------
Q
---------
Y
----------
V
------
E
-----
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
---
A
T
-
G
V
V
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
--
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
-------
K
G
-------
R
-----------
V
--
L
-------
S
---
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
RK
D
-
G
-
R
M
G
A
D
P
N
T
----
32
PsiBlast_CBE
78.87
42%
-87
- C6 -
4FZI
2
PGFS_TRYCC
B:
[16-284]
-------------
V
T
L
-
H
N
S
V
R
M
P
Q
L
G
L
G
V
---
W
---
R
A
Q
-
D
-----
G
A
E
-
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
---
N
E
R
G
V
G
----
Q
G
I
----
R
E
----
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
---------
G
----------
K
-----------
K
---------------------
K
---------
F
----------
V
------
D
-----
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
---
S
C
-
K
I
R
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
--
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
-------
S
--------------------
I
--
L
-------
K
---
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
-
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
--
E
-
D
K
R
I
G
A
D
P
D
N
F
---
33
PsiBlast_CBE
78.69
43%
-89
- C6 -
3D3F
1
GR_BACSU
B:
[7-270]
------------
T
V
K
L
-
H
N
G
V
E
M
P
W
F
G
L
G
V
---
F
---
K
V
E
-
N
G----
N
-
E
-
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
---
N
E
E
G
V
G
----
I
G
I
----
K
E
----
S
-----
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
---------
G
----------
K
--------------------------
D
------
K
---------
Y
----------
K
------
D
-----
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
---
D
A
-
E
I
K
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
--
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
-------
Q
G
-------
Q
-----------
L
--
L
-------
D
---
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
-
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
--
K
-
D
E
R
V
G
P
N
P
------
7
PsiBlast_PDB
78.63
42%
-88
- C6 -
3WBW
2
?
A:
[12-279]
-------
E
A
Q
-
T
V
I
S
F
-
H
D
G
H
T
M
P
Q
I
G
L
G
V
---
W
---
E
T
P
-
P
-----
D
-
E
-
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
---
N
E
E
G
V
G
----
K
G
L
----
E
D
-------------
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
---------
M
----------
P
-----------
A
Q
-------------
G
------
Q
---------
Y
----------
V
------
E
-----
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
---
A
T
-
G
V
V
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
--
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
-------
K
G
-------
R
-----------
V
--
L
-------
S
---
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
RK
D
-
G
-
R
M
G
A
D
P
N
T
----
4
PsiBlast_PDB
78.60
48%
-94
- C6 -
3O0K
4
?
A:
[27-283]
-----------
P
T
V
K
L
-
N
D
G
N
H
I
P
Q
L
G
Y
G
V
---
W
---
Q
I
S
-
N
-----
D
-
E
-
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
---
N
E
E
G
V
G
----
K
A
I
----
N
G
----
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
---------
M
----------
P
-----------
S
K
-------------
D
------
L
---------
F
----------
M
------
E
-----
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
---
E
S
-
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
--
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
-------
Q
G
-------------------
L
--
L
-------
E
---
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
------------------
30
PsiBlast_CBE
78.58
43%
-94
- C6 -
4F40
10
PGFS_LEIMA
B:
[13-283]
-------------
V
T
L
-
S
N
G
V
K
M
P
Q
F
G
L
G
V
---
W
---
Q
S
P
-
A
-----
G
-
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
---
N
E
E
S
V
G
----
A
G
L
----
R
A
----
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
RGKDIL---
S
----------
K
-----------
E
G
-------------
K
------
K
---------
Y
----------
L
------
D
-----
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
---
M
C
-
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
--
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
----------------
K
-----------
L
--
L
-------
S
---
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
-
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
--
T
-
N
S
R
Y
G
P
D
P
------
24
PsiBlast_CBE
78.56
48%
-96
- C6 -
3O0K
4
?
B:
[27-283]
-----------
P
T
V
K
L
-
N
D
G
N
H
I
P
Q
L
G
Y
G
V
---
W
---
Q
I
S
-
N
-----
D
-
E
-
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
---
N
E
E
G
V
G
----
K
A
I
----
N
G
----
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
---------
M
----------
P
-----------
S
K
-------------
D
------
L
---------
F
----------
M
------
E
-----
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
---
E
S
-
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
--
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
----------------------------
L
--
L
-------
E
---
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
------------------
17
PsiBlast_PDB
78.41
43%
-86
- C6 -
3D3F
1
GR_BACSU
A:
[7-270]
------------
T
V
K
L
-
H
N
G
V
E
M
P
W
F
G
L
G
V
---
F
---
K
V
E
-
N
G----
N
-
E
-
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
---
N
E
E
G
V
G
----
I
G
I
----
K
E
----
S
-----
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
---------
G
----------
K
--------------------------
D
------
K
---------
Y
----------
K
------
D
-----
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
---
D
A
-
E
I
K
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
--
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
-------
Q
G
-------
Q
-----------
L
--
L
-------
D
---
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
-
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
--
K
-
D
E
R
V
G
P
N
P
------
13
PsiBlast_PDB
78.24
42%
-87
- C6 -
4GIE
2
PGFS_TRYCC
A:
[16-284]
-------------
V
T
L
-
H
N
S
V
R
M
P
Q
L
G
L
G
V
---
W
---
R
A
Q
-
D
-----
G
A
E
-
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
---
N
E
R
G
V
G
----
Q
G
I
----
R
E
----
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
---------
G
----------
K
-----------
K
---------------------
K
---------
F
----------
V
------
D
-----
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
---
S
C
-
K
I
R
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
--
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
-------
S
G
-------
E
EAG--------
I
--
L
-------
K
---
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
-
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
--
E
-
D
K
R
I
G
A
D
P
D
N
F
---
9
PsiBlast_PDB
78.17
43%
-91
- C6 -
4F40
11
PGFS_LEIMA
A:
[13-283]
-------------
V
T
L
-
S
N
G
V
K
M
P
Q
F
G
L
G
V
---
W
---
Q
S
P
-
A
-----
G
-
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
---
N
E
E
S
V
G
----
A
G
L
----
R
A
----
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
RG
K
D
I
L
---
S
----------
K
-----------
E
G
-------------
K
------
K
---------
Y
----------
L
------
D
-----
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
---
M
C
-
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
--
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
----------------
K
-----------
L
--
L
-------
S
---
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
-
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
--
T
-
N
S
R
Y
G
P
D
P
------
117
HHSearch
78.15
42%
-82
- C6 -
4GIE
2
PGFS_TRYCC
A:
[17-286]
--------------
T
L
-
H
N
S
V
R
M
P
Q
L
G
L
G
V
---
W
---
R
A
Q
-
D
G----
A
-
E
-
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
---
N
E
R
G
V
G
----
Q
G
I
----
R
E
----
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
---------
G
----------
K
-----------
K
K
------------------------------
F
----------
V
------
D
-----
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
---
S
C
-
K
I
R
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
--
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
-------
S
G
-------
E
-----------
E
--
A
-------
G
ILK
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
-
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
--
E
D
K
R
I
G
-
A
D
P
D
N
F
F
P
-
35
PsiBlast_CBE
78.09
41%
-94
- C6 -
1VP5
1
?
B:
[15-277]
---------
V
-
P
K
V
T
L
-
N
N
G
V
E
M
P
I
L
G
Y
G
V
---
F
---
Q
I
P
-
P
-----
E
-
K
-
T
E
E
C
V
Y
E
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
---
N
E
E
G
V
G
----
R
A
I
----
K
R
----
A
IDEG-
I
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
----------------------
Q
-----------
P
F
-------------
G
------
D
---------
V
----------
H
------
C
-----
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
V
---
H
H
-
E
I
V
P
A
V
N
Q
I
E
I
H
P
F
Y
Q
R
--
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
A
-------
E
G
-------
R
KN---------
I
--
F
-------
Q
---
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
-
G
I
V
A
I
P
K
T
V
R
R
E
R
M
K
E
N
I
S
I
F
D
F
E
L
T
Q
E
D
M
E
K
I
A
T
L
D
--
E
-
G
-------------
19
PsiBlast_PDB
77.69
41%
-95
- C6 -
1VP5
1
?
A:
[15-277]
---------
V
-
P
K
V
T
L
-
N
N
G
V
E
M
P
I
L
G
Y
G
V
---
F
---
Q
I
P
-
P
-----
E
-
K
-
T
E
E
C
V
Y
E
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
---
N
E
E
G
V
G
----
R
A
I
----
K
R
----
A
I
D
E
G-
I
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
----------------------
Q
-----------
P
F
-------------
G
------
D
---------
V
----------
H
------
C
-----
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
V
---
H
H
-
E
I
V
P
A
V
N
Q
I
E
I
H
P
F
Y
Q
R
--
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
A
-------
E
G
-------
R
KN---------
I
--
F
-------
Q
---
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
-
G
I
V
A
I
P
K
T
V
R
R
E
R
M
K
E
N
I
S
I
F
D
F
E
L
T
Q
E
D
M
E
K
I
A
T
L
D
--
E
-
G
-------------
26
PsiBlast_CBE
77.67
43%
-86
- C6 -
1VBJ
2
PGFS_TRYBB
B:
[7-277]
-------
A
L
T
-
Q
S
L
K
L
-
S
N
G
V
M
M
P
V
L
G
F
G
M
---
W
---
K
L
Q
-
D
G----
N
-
E
-
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
---
N
E
E
S
A
G
----
R
A
I
----
A
S
----
C
-----
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
---------
G
----------
K
-----------
D
---------------------
K
---------
F
----------
I
------
D
-----
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
---
H
C
-
K
V
A
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
--
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
-------
Q
G
-------
H
-----------
L
--
V
-------
E
---
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
-
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
--
A
-
G
H
R
Y
G
P
D
P
E
V
F
---
6
PsiBlast_PDB
77.60
43%
-88
- C6 -
1VBJ
2
PGFS_TRYBB
A:
[7-277]
-------
A
L
T
-
Q
S
L
K
L
-
S
N
G
V
M
M
P
V
L
G
F
G
M
---
W
---
K
L
Q
-
D
G----
N
-
E
-
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
---
N
E
E
S
A
G
----
R
A
I
----
A
S
----
C
-----
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
---------
G
----------
K
-----------
D
---------------------
K
---------
F
----------
I
------
D
-----
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
---
H
C
-
K
V
A
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
--
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
-------
Q
G
-------
H
-----------
L
--
V
-------
E
---
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
-
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
--
A
-
G
H
R
Y
G
P
D
P
E
V
F
---
11
PsiBlast_PDB
77.55
42%
-89
- C6 -
3WBY
2
?
A:
[12-279]
-------
E
A
Q
-
T
V
I
S
F
-
H
D
G
H
T
M
P
Q
I
G
L
G
V
---
W
---
E
T
P
-
P
-----
D
-
E
-
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
A
T
A
R
L
Y
K
---
N
E
E
G
V
G
----
K
G
L
----
E
D
-------------
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
---------
M
----------
P
-----------
A
Q
-------------
G
------
Q
---------
Y
----------
V
------
E
-----
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
---
A
T
-
G
V
V
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
--
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
-------
K
G
-------
R
-----------
V
--
L
-------
S
---
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
RK
D
-
G
-
R
M
G
A
D
P
N
T
----
16
PsiBlast_PDB
77.36
47%
-87
- C6 -
1M9H
2
DKGA_CORSC
A:
[4-264]
-----------
P
S
I
V
L
-
N
D
G
N
S
I
P
Q
L
G
Y
G
V
---
Y
---
K
V
P
-
P
-----
A
-
D
-
T
Q
R
A
V
E
E
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
---
N
E
E
G
V
G
----
A
A
I
----
A
A
----
S
-----
G
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
---------
T
----------
P
-----------
A
A
-------------
D
------
N
---------
Y
----------
V
------
H
-----
A
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
A
---
A
T
-
G
V
V
P
A
V
N
Q
I
E
L
H
P
A
Y
Q
Q
--
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
G
-------
Q
G
-------
K
YD---------
L
--
F
-------
G
---
A
E
P
V
T
A
A
A
A
A
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
-
G
F
V
V
F
P
G
S
V
R
R
E
H
L
E
E
N
L
D
V
F
D
F
D
L
T
D
T
E
I
A
A
I
D
A
M
D
--
P
-
G
-------------
81
PsiBlast_CBE
77.06
36%
-97
- C6 -
4XO6
5
?
B:
[10-306]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
RSKI
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
VKPGEEVIPKD
E
N
-------------
G
------
K
---------
I
LFDT------
V
------
D
LCA--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
14
PsiBlast_PDB
77.02
47%
-90
- C6 -
1A80
1
DKGA_CORSC
A:
[3-263]
-----------
P
S
I
V
L
-
N
D
G
N
S
I
P
Q
L
G
Y
G
V
---
F
---
K
V
P
-
P
-----
A
-
D
-
T
Q
R
A
V
E
E
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
---
N
E
E
G
V
G
----
A
A
I
----
A
A
----
S
-----
G
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
---------
T
----------
P
-----------
A
A
-------------
D
------
N
---------
Y
----------
V
------
H
-----
A
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
A
---
A
T
-
G
V
V
P
A
V
N
Q
I
E
L
H
P
A
Y
Q
Q
--
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
G
-------
Q
G
-------
K
YD---------
L
--
F
-------
G
---
A
E
P
V
T
A
A
A
A
A
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
-
G
F
V
V
F
P
K
S
V
R
R
E
R
L
E
E
N
L
D
V
F
D
F
D
L
T
D
T
E
I
A
A
I
D
A
M
D
--
P
-
G
-------------
60
PsiBlast_CBE
76.81
36%
-95
- C6 -
4JTR
5
AK1C2_HUMAN
A:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
AP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEVIPKDEN--
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
70
PsiBlast_CBE
76.77
36%
-95
- C6 -
4JQ2
5
AK1C2_HUMAN
A:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEVIPKDEN--
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
62
PsiBlast_CBE
76.76
36%
-93
- C6 -
4JTQ
4
AK1C2_HUMAN
A:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
AP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
P
G
EEVIPKDEN--
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
77
PsiBlast_CBE
76.63
36%
-96
- C6 -
2HDJ
7
AK1C2_HUMAN
B:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
RSKI
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
VKPGEEVIPKD
E
N
-------------
G
------
K
---------
I
LFDT------
V
------
D
LCA--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
89
PsiBlast_CBE
76.53
36%
-97
- C6 -
4L1X
3
AK1C2_HUMAN
B:
[10-306]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
L
Y
N
---
N
E
E
Q
V
G
----
L
A
I
RSKI
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
VKPGEEVIPKD
E
N
-------------
G
------
K
---------
I
LFDT------
V
------
D
LCA--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
31
PsiBlast_CBE
76.53
42%
-84
- C6 -
3WBY
1
?
B:
[12-279]
-------
E
A
Q
-
T
V
I
S
F
-
H
D
G
H
T
M
P
Q
I
G
L
G
V
---
W
---
E
T
P
-
P
-----
D
-
E
-
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
A
T
A
R
L
Y
K
---
N
E
E
G
V
G
----
K
G
L
----
E
D
-------------
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
---------
M
----------
P
-----------
A
Q
-------------
G
------
Q
---------
Y
----------
V
------
E
-----
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
---
A
T
-
G
V
V
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
--
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
-------
K
G
-------
R
-----------
V
--
L
-------
S
---
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
RK
D
-
G
-
R
M
G
A
D
P
N
T
----
23
PsiBlast_CBE
76.52
48%
-90
- C6 -
3O0K
3
?
C:
[27-283]
-----------
P
T
V
K
L
-
N
D
G
N
H
I
P
Q
L
G
Y
G
V
---
W
---
Q
I
S
-
N
-----
D
-
E
-
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
---
N
E
E
G
V
G
----
K
A
I
----
N
G
----
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
---------
M
----------
P
-----------
S
K
-------------
D
------
L
---------
F
----------
M
------
E
-----
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
---
E
S
-
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
--
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
----------------------------
L
--
L
-------
E
---
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
------------------
22
PsiBlast_CBE
76.46
48%
-90
- C6 -
3O0K
3
?
D:
[27-283]
-----------
P
T
V
K
L
-
N
D
G
N
H
I
P
Q
L
G
Y
G
V
---
W
---
Q
I
S
-
N
-----
D
-
E
-
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
---
N
E
E
G
V
G
----
K
A
I
----
N
G
----
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
---------
M
----------
P
-----------
S
K
-------------
D
------
L
---------
F
----------
M
------
E
-----
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
---
E
S
-
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
--
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
----------------
K
-----------
L
--
L
-------
E
---
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
------------------
63
PsiBlast_CBE
76.40
36%
-97
- C6 -
4JQA
7
AK1C2_HUMAN
B:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
AP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEVIPKDEN--
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
68
PsiBlast_CBE
76.38
36%
-92
- C6 -
4JQ3
4
AK1C2_HUMAN
A:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
P
G
EEVIPKDEN--
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
87
PsiBlast_CBE
76.36
36%
-96
- C6 -
1J96
3
AK1C2_HUMAN
B:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
AP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
V
K
PGEEVIP------------------------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
74
PsiBlast_CBE
76.36
36%
-96
- C6 -
2IPJ
8
AK1C2_HUMAN
A:
[6-302]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
---
A
APA
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEV
I
P
K
D
EN--
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
64
PsiBlast_CBE
76.35
36%
-96
- C6 -
4JQA
5
AK1C2_HUMAN
A:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
AP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEVIPKDEN--
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
84
PsiBlast_CBE
76.33
36%
-97
- C6 -
4L1W
4
AK1C2_HUMAN
A:
[10-306]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
AP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
VKPGEEV
I
P
K
D
E
N
-------------
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
75
PsiBlast_CBE
76.32
36%
-98
- C6 -
4XO7
3
?
B:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
RSKI
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
VKPGEEVIPKD
E
N
-------------
G
------
K
---------
I
LFDT------
V
------
D
LCA--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
66
PsiBlast_CBE
76.28
36%
-99
- C6 -
4JQ4
5
AK1C2_HUMAN
A:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
AP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEVIPKDEN--
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
88
PsiBlast_CBE
76.26
36%
-96
- C6 -
1J96
3
AK1C2_HUMAN
A:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
AP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
V
K
PGEEVIPKD
E
N
-------------
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
72
PsiBlast_CBE
76.22
36%
-97
- C6 -
4JQ1
4
AK1C2_HUMAN
A:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
AP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEVIPKDEN--
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
114
HHSearch
76.14
43%
-89
- C6 -
1VBJ
2
PGFS_TRYBB
A:
[7-277]
-------
A
L
T
-
Q
S
L
K
L
-
S
N
G
V
M
M
P
V
L
G
F
G
M
---
W
---
K
L
Q
-
D
G----
N
-
E
-
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
---
N
E
E
S
A
G
----
R
A
I
----
A
S
----
C
-----
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
---------
G
----------
K
-----------
D
K
------------------------------
F
----------
I
------
D
-----
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
---
H
C
-
K
V
A
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
--
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
-------
Q
G
-------
H
-----------
L
--
V
-------
E
---
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
-
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
--
A
G
H
R
Y
G
-
P
D
P
E
V
F
---
73
PsiBlast_CBE
76.14
36%
-95
- C6 -
2IPJ
10
AK1C2_HUMAN
B:
[6-302]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
---
A
APA
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
RSKI
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEVIPKDEN--
G
------
K
---------
I
LFDT------
V
------
D
LCA--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
71
PsiBlast_CBE
76.14
36%
-98
- C6 -
4JQ1
5
AK1C2_HUMAN
B:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
RSKI
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEVIPKDEN--
G
------
K
---------
I
LFDT------
V
------
D
LCA--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
86
PsiBlast_CBE
76.07
36%
-95
- C6 -
1XJB
5
AK1C2_HUMAN
A:
[10-306]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
VKPGEEVIPKD
E
N
-------------
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
59
PsiBlast_CBE
76.05
36%
-97
- C6 -
4JTR
7
AK1C2_HUMAN
B:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEVIPKDEN--
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
90
PsiBlast_CBE
76.03
36%
-98
- C6 -
4L1X
4
AK1C2_HUMAN
A:
[10-306]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
AP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
L
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
VKPGEEV
I
P
K
D
E
N
-------------
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
85
PsiBlast_CBE
76.01
36%
-95
- C6 -
1XJB
5
AK1C2_HUMAN
B:
[10-306]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
AP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
VKPGEEVIPKD
E
N
-------------
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
61
PsiBlast_CBE
75.97
36%
-98
- C6 -
4JTQ
9
AK1C2_HUMAN
B:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
AP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEV
I
P
K
D
EN--
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
123
HHSearch
75.95
45%
-92
- C6 -
4F40
11
PGFS_LEIMA
A:
[14-275]
--------------
T
L
-
S
N
G
V
K
M
P
Q
F
G
L
G
V
---
W
---
Q
S
P
A
G
-----
E
-
V
-
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
---
N
E
E
S
V
G
----
A
G
L
----
R
A
----
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
---------
R
----------
G
-----------
K
D
-------------
I
L
S
K
EGK
K
---------
Y
----------
L
------
D
-----
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
---
M
C
-
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
--
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
----------------
K
-----------
L
--
L
-------
S
---
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
-
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
--
T
---------------
82
PsiBlast_CBE
75.94
36%
-97
- C6 -
4XO6
6
?
A:
[10-306]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
AP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
V
K
PGEEVIPKD
E
N
-------------
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
67
PsiBlast_CBE
75.92
36%
-96
- C6 -
4JQ3
8
AK1C2_HUMAN
B:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEV
I
P
K
D
EN--
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
83
PsiBlast_CBE
75.85
36%
-96
- C6 -
4L1W
3
AK1C2_HUMAN
B:
[10-306]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
RSKI
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
VKPGEEVIPKD
E
N
-------------
G
------
K
---------
I
LFDT------
V
------
D
LCA--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
54
PsiBlast_CBE
75.83
33%
-100
- C6 -
4GAC
2
AK1A1_MOUSE
B:
[2-303]
---------
A
-
S
S
V
L
L
-
H
T
G
Q
K
M
P
L
I
G
L
G
T
---
W
---
K
S
E
-
P
-----
G
-
Q
-
V
K
A
A
I
K
H
A
L
S
A
G
Y
R
H
I
D
C
A
S
V
Y
G
---
N
E
T
E
I
G
----
E
A
L
----
K
E
----
S
VGSGK
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
---------
Y
----------
A
F
E
RGDN-----
P
F
-------------
P
------
K
GTVRYDSTH
Y
----------
K
------
E
-----
T
W
K
A
L
E
V
L
V
A
K
G
L
V
K
A
L
G
L
S
N
F
N
S
R
Q
I
D
D
V
L
S
---
V
A
-
S
V
R
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
--
N
E
L
I
A
H
C
H
A
R
G
L
E
V
T
A
Y
S
P
L
G
-----------------PDEPV------
L
--
L
-------
E
---
E
P
V
V
L
A
L
A
E
K
H
G
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
-
K
V
I
C
I
P
K
S
I
N
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
--
K
-
N
W
R
-----------
78
PsiBlast_CBE
75.80
36%
-96
- C6 -
2HDJ
5
AK1C2_HUMAN
A:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
V
K
P
G
EEV
I
P
K
D
E
N
-------------
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
69
PsiBlast_CBE
75.67
36%
-98
- C6 -
4JQ2
7
AK1C2_HUMAN
B:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEV
I
P
K
D
EN--
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
76
PsiBlast_CBE
75.54
36%
-97
- C6 -
4XO7
4
?
A:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
AP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
VKPGEEV
I
P
K
D
E
N
-------------
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
80
PsiBlast_CBE
75.44
36%
-92
- C6 -
1IHI
2
AK1C2_HUMAN
A:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
VKPGEEV
I
P
K
D
E
N
-------------
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
65
PsiBlast_CBE
75.22
36%
-95
- C6 -
4JQ4
7
AK1C2_HUMAN
B:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEV
I
P
K
D
EN--
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
--------PWVDPNSPV--
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
126
HHSearch
75.14
42%
-93
* C6 *
1VP5
1
?
A:
[20-276]
---------------
L
-
N
N
G
V
E
M
P
I
L
G
Y
G
V
---
F
---
Q
I
P
-
P
-----
E
-
K
-
T
E
E
C
V
Y
E
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
---
N
E
E
G
V
G
----
R
A
I
----
K
R
----
A
I
D
E
G-
I
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
P
---------
F
----------
G
-----------
D
-------------------------------
V
----------
H
------
C
-----
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
V
---
H
H
-
E
I
V
P
A
V
N
Q
I
E
I
H
P
F
Y
Q
R
--
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
A
-------
E
G
-------
R
-----------
K
NI
F
-------
Q
---
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
-
G
I
V
A
I
P
K
T
V
R
R
E
R
M
K
E
N
I
S
I
F
D
F
E
L
T
Q
E
D
M
E
K
I
A
T
L
D
--
E
---------------
79
PsiBlast_CBE
74.84
36%
-92
- C6 -
1IHI
2
AK1C2_HUMAN
B:
[8-304]
-------------
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
---
N
E
E
Q
V
G
----
L
A
I
RSKI
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
VKPGEEVIPKD
E
N
-------------
G
------
K
---------
I
LFDT------
V
------
D
LCA--
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
93
PsiBlast_CBE
74.36
35%
-93
- C6 -
4YVP
2
AK1C1_HUMAN
B:
[7-304]
------------
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
T
K
L
A
I
E
A
G
F
R
H
I
D
S
A
H
L
Y
N
---
N
E
E
Q
V
G
----
L
A
I
RSKI
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEVIPKDEN--
G
------
K
---------
I
LFDT------
V
------
D
LCA--
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
124
HHSearch
74.23
43%
-88
- C6 -
3WBW
2
?
A:
[13-268]
---------
A
-
Q
T
V
I
S
F
H
D
G
H
T
M
P
Q
I
G
L
G
V
---
W
---
E
T
P
-
P
-----
D
-
E
-
T
A
E
V
V
K
E
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
---
N
E
E
G
V
G
----
K
G
L
----
E
D
-------------
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
---------
M
----------
P
-----------
A
Q
-------------
G
------
Q
---------
Y
----------
V
------
E
-----
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
---
A
T
-
G
V
V
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
--
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
-------
K
G
-------
R
-----------
V
--
L
-------
S
---
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
--
R
---------------
94
PsiBlast_CBE
74.22
35%
-96
- C6 -
4YVP
2
AK1C1_HUMAN
A:
[7-304]
------------
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
T
K
L
A
I
E
A
G
F
R
H
I
D
S
A
H
L
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEV
I
P
K
D
EN--
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
96
PsiBlast_CBE
73.95
35%
-95
- C6 -
3C3U
3
AK1C1_HUMAN
A:
[7-304]
------------
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
T
K
L
A
I
E
A
G
F
R
H
I
D
S
A
H
L
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEV
I
P
K
D
EN--
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
92
PsiBlast_CBE
73.90
35%
-96
- C6 -
3GUG
3
AK1C1_HUMAN
A:
[7-304]
------------
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
T
K
L
A
I
E
A
G
F
R
H
I
D
S
A
H
L
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
VKPGEEV
I
P
K
D
E
N
-------------
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
98
PsiBlast_CBE
73.86
34%
-91
- C6 -
1LWI
1
DIDH_RAT
A:
[8-304]
-------------
V
A
L
-
N
D
G
N
F
I
P
V
L
G
F
G
T
---
T
V
P---
A
-
K
-----
D
-
E
-
V
I
K
A
T
K
I
A
I
D
N
G
F
R
H
F
D
S
A
Y
L
Y
E
---
V
E
E
E
V
G
----
Q
A
I
----
R
S
----
K
I
E
D
G-
T
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
T
F
H
R
P
E
L
V
R
T
C
L
E
K
T
L
K
S
T
Q
L
D
Y
V
D
L
Y
I
I
H
F
P
---------
M
----------
A
LQPGDIF
F
---
P
R
-------------
D
------
E
---------
H
GKLL
F
E
T
V
D
I
C
------
D
-----
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
C
R
Q
L
E
R
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
L
Y
L
N
Q
--
S
K
M
L
D
Y
C
K
S
K
D
I
I
L
V
S
Y
C
T
L
G
-------
S
---------KTWVDQKSPV-
L
--
L
-------
D
---
D
P
V
L
C
A
I
A
K
K
Y
K
Q
T
P
A
L
V
A
L
R
Y
Q
L
Q
R
-
G
V
V
P
L
I
R
S
F
N
A
K
R
I
K
E
L
T
Q
V
F
E
F
Q
L
A
S
E
D
M
K
A
L
D
G
L
N
--
R
-
N
F
R
-----------
97
PsiBlast_CBE
73.78
34%
-91
- C6 -
1LWI
1
DIDH_RAT
B:
[8-304]
-------------
V
A
L
-
N
D
G
N
F
I
P
V
L
G
F
G
T
---
T
VP---
A
-
K
-----
D
-
E
-
V
I
K
A
T
K
I
A
I
D
N
G
F
R
H
F
D
S
A
Y
L
Y
E
---
V
E
E
E
V
G
----
Q
A
I
----
R
S
----
K
IEDG-
T
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
T
F
H
R
P
E
L
V
R
T
C
L
E
K
T
L
K
S
T
Q
L
D
Y
V
D
L
Y
I
I
H
F
P
---------
M
----------
A
LQPGDIFF---
P
R
-------------
D
------
E
---------
H
GKLLFETVDI
C
------
D
-----
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
C
R
Q
L
E
R
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
L
Y
L
N
Q
--
S
K
M
L
D
Y
C
K
S
K
D
I
I
L
V
S
Y
C
T
L
G
-------
S
---------KTWVDQKSPV-
L
--
L
-------
D
---
D
P
V
L
C
A
I
A
K
K
Y
K
Q
T
P
A
L
V
A
L
R
Y
Q
L
Q
R
-
G
V
V
P
L
I
R
S
F
N
A
K
R
I
K
E
L
T
Q
V
F
E
F
Q
L
A
S
E
D
M
K
A
L
D
G
L
N
--
R
-
N
F
R
-----------
128
HHSearch
73.53
38%
-86
- C6 -
3H7U
2
AKRC9_ARATH
A:
[27-311]
------------
F
F
K
L
-
N
T
G
A
K
F
P
S
V
G
L
G
T
---
W
---
Q
A
S
-
P
-----
G
-
L
-
V
G
D
A
V
A
A
A
V
K
I
G
Y
R
H
I
D
C
A
Q
I
Y
G
---
N
E
K
E
I
G
----
A
V
L
----
K
K
----
L
F
E
D
R-
V
V
K
R
E
D
L
F
I
T
S
K
L
W
C
T
D
H
D
P
Q
D
V
P
E
A
L
N
R
T
L
K
D
L
Q
L
E
Y
V
D
L
Y
L
I
H
W
P
---------
A
----------
R
-----------
I
K
K
GSVGIKPENLLP
V
------
D
---------
I
----------
P
------
S
-----
T
W
K
A
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
S
T
K
K
L
A
D
L
L
E
---
L
A
-
R
V
P
P
A
V
N
Q
V
E
C
H
P
S
W
R
Q
--
T
K
L
Q
E
F
C
K
S
K
G
V
H
L
S
A
Y
S
P
L
G
-------
S
P
-------
G
-----------
T
--
T
WLKSDVL
K
---
N
P
I
L
N
M
V
A
E
K
L
G
K
S
P
A
Q
V
A
L
R
W
G
L
Q
M
-
G
H
S
V
L
P
K
S
T
N
E
G
R
I
K
E
N
F
N
V
F
D
W
S
I
P
D
Y
M
F
A
K
F
A
E
I
E
--
Q
-
A
R
L
V
----------
95
PsiBlast_CBE
73.47
35%
-93
- C6 -
3NTY
3
AK1C1_HUMAN
A:
[7-304]
------------
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
Y
AP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
T
K
L
A
I
E
A
G
F
R
H
I
D
S
A
H
L
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
-----------
V
K
PGEEV
I
P
K
D
EN--
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
49
PsiBlast_CBE
73.43
37%
-95
- C6 -
3H7U
2
AKRC9_ARATH
A:
[24-294]
--------
A
I
-
T
F
F
K
L
-
N
T
G
A
K
F
P
S
V
G
L
G
T
---
W
---
Q
A
S
-
P
-----
G
-
L
-
V
G
D
A
V
A
A
A
V
K
I
G
Y
R
H
I
D
C
A
Q
I
Y
G
---
N
E
K
E
I
G
----
A
V
L
----
K
K
L
F
E
D
R
-----
V
V
K
R
E
D
L
F
I
T
S
K
L
W
C
T
D
H
D
P
Q
D
V
P
E
A
L
N
R
T
L
K
D
L
Q
L
E
Y
V
D
L
Y
L
I
H
W
P
---------
A
R
I
K
K
GSVGIK
P
-----------
E
N
-------------
L
------
L
---------
P
----------
V
------
D
I
P
S
--
T
W
K
A
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
S
T
K
K
L
A
D
L
L
E
---
L
A
-
R
V
P
P
A
V
N
Q
V
E
C
H
P
S
W
R
Q
--
T
K
L
Q
E
F
C
K
S
K
G
V
H
L
S
A
Y
S
P
L
G
SPGTTWL
K
S
-------
D
-----------
V
--
L
-------
K
---
N
P
I
L
N
M
V
A
E
K
L
G
K
S
P
A
Q
V
A
L
R
W
G
L
Q
M
-
G
H
S
V
L
P
K
S
T
N
E
G
R
I
K
E
N
F
N
V
F
D
W
S
I
------------------------------
91
PsiBlast_CBE
73.38
35%
-97
- C6 -
1MRQ
3
AK1C1_HUMAN
A:
[7-304]
------------
C
V
K
L
-
N
D
G
H
F
M
P
V
L
G
F
G
T
YAP
A
---
E
V
P
-
K
-----
S
-
K
-
A
L
E
A
T
K
L
A
I
E
A
G
F
R
H
I
D
S
A
H
L
Y
N
---
N
E
E
Q
V
G
----
L
A
I
R
S
K
I
A
D
----
G
-----
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
---------
V
----------
S
VKPGEEV
I
P
K
D
E
N
-------------
G
------
K
---------
I
L
F
D
T
------
V
------
D
L
C
A
--
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
KPG
L
K
-
Y
-
K
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
--
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
G
-------
S
H
-------
R
EEPWVDPNSPV
L
--
L
-------
E
---
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
-
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
--
R
-
N
V
R
-----------
51
PsiBlast_CBE
72.51
33%
-86
- C6 -
2VDG
6
ALDR_HORVU
A:
[37-318]
---------
Q
-
D
H
F
V
L
-
K
S
G
H
A
M
P
A
V
G
L
G
T
---
W
---
R
A
G
-
S
-----
D
-
T
-
A
H
S
V
R
T
A
I
T
E
A
G
Y
R
H
V
D
T
A
A
E
Y
G
---
V
E
K
E
V
G
----
K
G
L
----
K
A
----
A
M
E
A
--
G
I
D
R
K
D
L
F
V
T
S
K
I
W
C
T
N
L
A
P
E
R
V
R
P
A
L
E
N
T
L
K
D
L
Q
L
D
Y
I
D
L
Y
H
I
H
W
P
F
R
L
K
DGAHM
P
----------
P
-----------
E
A
-------------
G
------
E
---------
V
----------
L
------
E
F
D
M
E
G
V
W
K
E
M
E
N
L
V
K
D
G
L
V
K
D
I
G
V
C
N
Y
T
V
T
K
L
N
R
L
L
R
---
S
A
-
K
I
P
P
A
V
C
Q
M
E
M
H
P
G
W
K
N
--
D
K
I
F
E
A
C
K
K
H
G
I
H
I
T
A
Y
S
P
L
G
-------
S
S
-------
E
KN---------
L
--
A
-------
H
---
D
P
V
V
E
K
V
A
N
K
L
N
K
T
P
G
Q
V
L
I
K
W
A
L
Q
R
-
G
T
S
V
I
P
K
S
S
K
D
E
R
I
K
E
N
I
Q
V
F
G
W
E
I
P
E
E
D
F
K
V
L
C
S
I
K
--
D
-
E
K
R
V
----------
50
PsiBlast_CBE
71.36
36%
-101
- C6 -
3H7R
13
AKRC8_ARATH
A:
[25-290]
---------
I
-
R
F
F
E
L
-
N
T
G
A
K
L
P
C
V
G
L
G
T
---
Y
---
A
M
------------
V
A
T
A
I
E
Q
A
I
K
I
G
Y
R
H
I
D
C
A
S
I
Y
G
---
N
E
K
E
I
G
G
V
L
K
K
L
I
----
G
D
----
G
-----
F
V
K
R
E
E
L
F
I
T
S
K
L
W
S
N
D
H
L
P
E
D
V
P
K
A
L
E
K
T
L
Q
D
L
Q
I
D
Y
V
D
L
Y
L
I
H
W
P
---------
A
----------
S
LKKESLM----
P
T
-------------
P
------
E
---------
M
----------
L
TKPD
I
T
S
-----
T
W
K
A
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
S
S
K
K
L
T
D
L
L
N
---
V
A
-
R
V
T
P
A
V
N
Q
V
E
C
H
P
V
W
Q
Q
--
Q
G
L
H
E
L
C
K
S
K
G
V
H
L
S
G
Y
S
P
L
G
-------
S
Q
SKGEVR
L
K
-----------
V
--
L
-------
Q
---
N
P
I
V
T
E
V
A
E
K
L
G
K
T
T
A
Q
V
A
L
R
W
G
L
Q
T
-
G
H
S
V
L
P
K
S
S
S
G
A
R
L
K
E
N
L
D
V
F
D
W
S
I
------------------------------
122
HHSearch
67.29
31%
-87
- C6 -
5C7H
1
?
A:
[2-270]
------
H
D
P
I
-
P
T
I
A
F
-
P
D
G
R
K
V
P
A
L
G
Q
G
T
---
W
---
R
M
G
-
E
NRAK
T
A
-
D
-
E
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----
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------------
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----------
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---------------------
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-----
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---
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--
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-------
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---
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--
P
---------------