@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3025c: (2016-05-16 )
MAYLDHAATTPMHPAAIEAMAAVQRTIGNASSLHTSGRSARRRIEEARELIADKLGARPSEVIFTAGGTESDNLAVKGIYWARRDAEPHRRRIVTTEVEHHAVLDSVNWLVEHEGAHVTWLPTAADGSVSATALREALQSHDDVALVSVMWANNEVGTILPIAEMSVVAMEFGVPMHSDAIQAVGQLPLDFGASGLSAMSVAGHKFGGPPGVGALLLRRDVTCVPLMHGGGQERDIRSGTPDVASAVGMATAAQIAVDGLEENSARLRLLRDRLVEGVLAEIDDVCLNGADDPMRLAGNAHFTFRGCEGDALLMLLDANGIECSTGSACTAGVAQPSHVLIAMGVDAASARGSLRLSLGHTSVEADVDAALEVLPGAVARARRAALAAAGASR
Atome Classification :
(30 SA)
-.........10.......-.20.-....---.-.-..-30........40........50........60........70........--80....-----.-----...90....-.....100.......110.......120-...-....130.......140.......150.......160....--...170----.----------.--..---....180.......190.......200.......210......---.-------220..-------....---...230.......240.......250.......260.......----270.......280.......290--..--..--....300.......--.310.......320.......330.-.-.....340.......350.......360.......370.......380.......390.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MAYLDHAATTPM
H
P
A
A
I
E
-
A
M
-
A
-
A
V
Q
R
---
T
-I-GN-
A
S
S
LHTS
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
LGARPS
E
V
I
F
TAGGTESD
N
L
A
V
K
G
I
--
Y
W
ARRD-----A-----EPHR-
R
R
I
V
-
T
TEV
E
H
H
A
V
L
D
S
V
N
W
L
V
EHEG
A
H
V
T
W
L
P-TAA-DGS
V
S
A
T
A
L
R
E
A
L
Q
SHDD
V
A
L
V
S
V
M
WANNEV
G
T
I
L
PI
A
E
M
S
--
V
V
A
ME-----F----------G--VP---M
H
S
D
A
I
Q
A
V
GQL
P
L
D
FGASG
L
S
A
M
SVAGHKFGGPP
G
V
G
A
L
L
L
R---R-------D--V
T
-------
C
V
P
L
---MHGGGQERDIRSG
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
VDGLEE
N
S
A
R
L
R
L
----
L
R
D
R
L
V
E
G
V
L
A
E
I
D
D
V
CLNGAD---
D
P
--
M
R--LAGN
A
-
H
F
T
F
RGCE--G
D
A
L
L
M
L
L
DANGIECSTGSACTAGV-A-QP
S
H
V
L
I
A
MGVDAASAR
G
S
L
R
L
SLGHTSV
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
AAAGASR
1
PsiBlast_PDB
98.85
99%
-102
- C2 -
4ISY
3
ISCSL_MYCTU
A:
[13-398]
--
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
-
A
M
-
A
-
A
V
Q
R
---
T
-
I
-
G
N
-
A
S
S
L
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
G
I
--
Y
W
A
R
R
D
-----
A
-----
E
P
H
R
-
R
R
I
V
-
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
H
E
G
A
H
V
T
W
L
P
-
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
--
V
V
A
M
E
-----
F
----------
G
--
V
P
---
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
---
R
-------
D
--
V
T
-------
C
V
P
L
---
M
H
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
L
R
L
----
L
R
D
R
L
V
E
G
V
L
A
E
I
D
D
V
C
L
N
G
A
D
---
D
P
--
M
R
--
L
A
G
N
A
-
H
F
T
F
R
G
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
A
------
46
HHSearch
98.69
100%
-101
- C2 -
4ISY
3
ISCSL_MYCTU
A:
[12-398]
-
S
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
-
A
M
-
A
-
A
V
Q
R
---
T
-
I
-
G
N
-
A
S
S
L
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
G
I
--
Y
W
A
R
R
D
-----
A
-----
E
P
H
R
-
R
R
I
V
-
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
H
E
G
A
H
V
T
W
L
P
-
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
--
V
V
A
M
E
-----
F
----------
G
--
V
P
---
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
---
R
-------
D
--
V
T
-------
C
V
P
L
---
M
H
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
L
R
L
----
L
R
D
R
L
V
E
G
V
L
A
E
I
D
D
V
C
L
N
G
A
D
---
D
P
--
M
R
--
L
A
G
N
A
-
H
F
T
F
R
G
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
A
------
34
Fugue
98.37
99%
-101
- C2 -
4ISY
3
ISCSL_MYCTU
A:
[12-398]
-
S
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
-
A
M
-
A
-
A
V
Q
R
---
T
-
I
-
G
N
-
A
S
S
L
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
G
I
--
Y
W
A
R
R
D
-----
A
-----
E
P
H
R
-
R
R
I
V
-
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
H
E
G
A
H
V
T
W
L
P
-
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
--
V
V
A
M
E
-----
F
----------
G
--
V
P
---
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
---
R
-------
D
--
V
T
-------
C
V
P
L
---
M
H
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
L
R
L
----
L
R
D
R
L
V
E
G
V
L
A
E
I
D
D
V
C
L
N
G
A
D
---
D
P
--
M
R
--
L
A
G
N
A
-
H
F
T
F
R
G
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
A
------
21
PsiBlast_CBE
97.52
99%
-101
- C2 -
4ISY
1
ISCSL_MYCTU
D:
[13-387]
--
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
-
A
M
-
A
-
A
V
Q
R
---
T
-
I
-
G
N
-
A
S
S
L
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
G
I
--
Y
W
A
R
R
D
-----
A
-----
E
P
H
R
-
R
R
I
V
-
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
H
E
G
A
H
V
T
W
L
P
-
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
--
V
V
A
M
E
-----
F
----------
G
--
V
P
---
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
---
R
-------
D
--
V
T
-------
C
V
P
L
---
M
H
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
L
R
L
----
L
R
D
R
L
V
E
G
V
L
A
E
I
D
D
V
C
L
N
G
A
D
---
D
P
--
M
R
--
L
A
G
N
A
-
H
F
T
F
R
G
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
-----------------
22
PsiBlast_CBE
97.35
99%
-101
- C2 -
4ISY
3
ISCSL_MYCTU
C:
[13-387]
--
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
-
A
M
-
A
-
A
V
Q
R
---
T
-
I
-
G
N
-
A
S
S
L
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
G
I
--
Y
W
A
R
R
D
-----
A
-----
E
P
H
R
-
R
R
I
V
-
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
H
E
G
A
H
V
T
W
L
P
-
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
--
V
V
A
M
E
-----
F
----------
G
--
V
P
---
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
---
R
-------
D
--
V
T
-------
C
V
P
L
---
M
H
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
L
R
L
----
L
R
D
R
L
V
E
G
V
L
A
E
I
D
D
V
C
L
N
G
A
D
---
D
P
--
M
R
--
L
A
G
N
A
-
H
F
T
F
R
G
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
A
---------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
-----------------
23
PsiBlast_CBE
95.76
99%
-100
- C2 -
4ISY
2
ISCSL_MYCTU
B:
[13-387]
--
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
-
A
M
-
A
-
A
V
Q
R
---
T
-
I
-
G
N
-
A
S
S
L
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
G
I
--
Y
W
A
R
R
D
-----
A
-----
E
P
H
R
-
R
R
I
V
-
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
H
E
G
A
H
V
T
W
L
P
-
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
--
V
V
A
M
E
-----
F
----------
G
--
V
P
---
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
---
R
-------
D
--
V
T
-------
C
V
P
L
---
M
H
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
L
R
L
----
L
R
D
R
L
V
E
G
V
L
A
E
I
D
D
V
C
L
N
G
A
D
---
D
P
--
M
R
--
L
A
G
N
A
-
H
F
T
F
R
G
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
-----------------
7
PsiBlast_PDB
80.11
39%
-92
- C2 -
4HVK
12
ISCS2_ARCFU
A:
[2-374]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
-
A
M
L
P
-
Y
M
T
E
---
S
-
F
-
G
N
-
P
S
S
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
----
Y
A
M
R
N
-----
A
-----
R
-
K
G
-
K
H
I
L
-
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
G
F
E
V
E
Y
I
P
-
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
--
E
V
-
L
A
-----
G
----------
K
--
A
A
---
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
-------
E
--
A
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
----
L
R
D
R
I
I
D
N
V
L
-
K
I
E
E
S
Y
L
N
G
H
P
---
E
K
---
R
--
L
P
N
N
V
-
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
----------
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
-----------
4
PsiBlast_PDB
79.88
39%
-91
- C2 -
4R5F
12
ISCS2_ARCFU
A:
[2-374]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
-
A
M
L
P
-
Y
M
T
E
---
S
-
F
-
G
N
-
P
S
S
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
----
Y
A
M
R
N
-----
A
-----
R
-
K
G
-
K
H
I
L
-
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
G
F
E
V
E
Y
I
P
-
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
--
E
V
-
L
A
-----
G
----------
K
--
A
A
---
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
K
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
-------
E
--
A
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
----
L
R
D
R
I
I
D
N
V
L
-
K
I
E
E
S
Y
L
N
G
H
P
---
E
K
---
R
--
L
P
N
N
V
-
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
----------
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
-----------
47
HHSearch
79.63
39%
-92
* C2 *
4HVK
12
ISCS2_ARCFU
A:
[2-378]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
-
A
M
-
L
-
P
Y
M
T
---
E
S
F
-
G
N
-
P
S
S
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
--
A
M
R
N
A
-------------
R
K
G
-
K
H
I
L
-
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
-
Q
G
F
E
V
E
Y
I
P
-
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
--
E
V
L
A
G
----------------
K
--
A
A
---
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
-------
E
--
A
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
----
L
R
D
R
I
I
D
N
V
L
K
I
-
E
E
S
Y
L
N
G
H
----
P
E
--
K
R
--
L
P
N
N
V
-
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
----------
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
P
-------
26
PsiBlast_CBE
79.46
39%
-90
- C2 -
4EB5
5
ISCS2_ARCFU
B:
[2-374]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
-
A
M
L
P
-
Y
M
T
E
---
S
-
F
-
G
N
-
P
S
S
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
----
Y
A
M
R
N
-----
A
-----
R
-
K
G
-
K
H
I
L
-
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
G
F
E
V
E
Y
I
P
-
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
--
E
V
-
L
A
-----
G
----------
K
--
A
A
---
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
-------
E
--
A
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
----
L
R
D
R
I
I
D
N
V
L
-
K
I
E
E
S
Y
L
N
G
H
P
---
E
K
---
R
--
L
P
N
N
V
-
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
T
-
L
-
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
-----------
6
PsiBlast_PDB
79.22
39%
-87
- C2 -
4EB7
7
ISCS2_ARCFU
A:
[2-374]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
-
A
M
L
P
-
Y
M
T
E
---
S
-
F
-
G
N
-
P
S
S
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
----
Y
A
M
R
N
-----
A
-----
R
-
K
G
-
K
H
I
L
-
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
G
F
E
V
E
Y
I
P
-
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
--
E
V
-
L
A
-----
G
----------
K
--
A
A
---
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
-------
E
--
A
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
----
L
R
D
R
I
I
D
N
V
L
-
K
I
E
E
S
Y
L
N
G
H
P
---
E
K
---
R
--
L
P
N
N
V
-
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
-
T
-
L
-
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
-----------
5
PsiBlast_PDB
79.02
39%
-88
- C2 -
4EB5
6
ISCS2_ARCFU
A:
[2-374]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
-
A
M
L
P
-
Y
M
T
E
---
S
-
F
-
G
N
-
P
S
S
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
----
Y
A
M
R
N
-----
A
-----
R
-
K
G
-
K
H
I
L
-
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
G
F
E
V
E
Y
I
P
-
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
--
E
V
-
L
A
-----
G
----------
K
--
A
A
---
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
-------
E
--
A
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
----
L
R
D
R
I
I
D
N
V
L
-
K
I
E
E
S
Y
L
N
G
H
P
---
E
K
---
R
--
L
P
N
N
V
-
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
T
-
L
-
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
-----------
25
PsiBlast_CBE
78.81
39%
-89
- C2 -
4EB7
4
ISCS2_ARCFU
B:
[2-374]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
-
A
M
L
P
-
Y
M
T
E
---
S
-
F
-
G
N
-
P
S
S
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
----
Y
A
M
R
N
-----
A
-----
R
-
K
G
-
K
H
I
L
-
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
G
F
E
V
E
Y
I
P
-
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
--
E
V
-
L
A
-----
G
----------
K
--
A
A
---
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
-------
E
--
A
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
----
L
R
D
R
I
I
D
N
V
L
-
K
I
E
E
S
Y
L
N
G
H
P
---
E
K
---
R
--
L
P
N
N
V
-
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
T
-
L
-
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
-----------
24
PsiBlast_CBE
78.40
40%
-89
- C2 -
3LVJ
2
ISCS_ECO57
B:
[25-400]
---
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
-
K
M
-
M
-
Q
F
M
T
MDG
T
-
F
-
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
-----
A
A
N
F
-----
Y
-----
Q
K
K
G
-
K
H
I
I
-
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
E
G
F
E
V
T
Y
L
A
-
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
--
E
M
C
R
A
-----
R
----------
G
--
I
I
---
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
---
R
-------
K
PR
V
R
-------
I
E
A
Q
---
M
H
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
M
A
T
E
M
E
R
L
R
G
----
L
R
N
R
L
W
N
G
I
-
K
D
I
E
E
V
Y
L
N
G
-----
D
L
--
E
H
--
G
A
P
N
I
L
N
V
S
F
N
Y
V
E
--
G
E
S
L
I
M
A
L
--
K
D
L
A
V
S
S
G
S
A
C
-----
L
-
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
R
-----------
35
Fugue
77.38
36%
-95
- C2 -
1ECX
2
?
A:
[1-376]
M
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
-
E
M
-
I
-
V
F
Y
R
---
E
-
K
Y
G
N
-
P
N
S
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
--
A
E
T
F
E
K
-----
R
--------
K
-
R
T
I
I
-
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
M
-
K
G
F
K
V
K
Y
V
P
-
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
--
R
I
V
K
K
-----
K
----------
N
KE
T
L
---
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
---
K
-------
G
--
V
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
----
L
R
S
K
L
V
S
G
L
M
N
L
--
G
A
H
I
I
T
P
L
---
E
I
---
S
--
L
P
N
T
L
-
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
--------------
T
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------------
27
PsiBlast_CBE
76.85
36%
-88
- C2 -
1ECX
2
?
B:
[3-367]
--
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
-
E
M
-
I
-
V
F
Y
R
E--
K
-
Y
-
G
N
-
P
N
S
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
-----
A
E
T
-----
F
-----
E
K
R
K
-
R
T
I
I
-
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
K
G
F
K
V
K
Y
V
P
-
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
--
R
I
V
K
K
-----
K
----------
N
--
K
E
TL-
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
---
K
-------
G
--
V
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
----
L
R
S
K
L
V
S
G
L
M
N
L
G
A
H
I
I
--------
T
P
--
L
E
IS
L
P
N
T
L
-
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
-------------
R
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
---------------------
2
PsiBlast_PDB
76.45
40%
-88
- C2 -
3LVJ
2
ISCS_ECO57
A:
[25-400]
---
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
-
K
M
-
M
-
Q
F
M
T
MDG
T
-
F
-
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
-----
A
A
N
F
-----
Y
-----
Q
K
K
G
-
K
H
I
I
-
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
E
G
F
E
V
T
Y
L
A
-
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
--
E
M
C
R
A
-----
R
----------
G
--
I
I
---
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
---
R
-------
K
P
R
V
R
-------
I
E
A
Q
---
M
H
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
M
A
T
E
M
E
R
L
R
G
----
L
R
N
R
L
W
N
G
I
-
K
D
I
E
E
V
Y
L
N
G
-----
D
L
--
E
H
--
G
A
P
N
I
L
N
V
S
F
N
Y
V
E
--
G
E
S
L
I
M
A
L
--
K
D
L
A
V
S
S
G
------
S
-
L
-
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
R
-----------
45
HHSearch
76.41
37%
-95
- C2 -
1EG5
3
?
A:
[2-376]
-
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
-
E
M
-
I
-
V
F
Y
R
---
E
K
Y
-
G
N
-
P
N
S
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
--
A
E
T
F
--------------
E
K
R
-
K
R
T
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
M
-
K
G
F
K
V
K
Y
V
P
-
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
--
R
I
V
K
K
K
N---
K
----------
E
--
T
L
---
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
---
K
-------
G
--
V
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
----
L
R
S
K
L
V
S
G
L
M
N
L
--
G
A
H
I
I
T
P
L
---
E
---
I
S
--
L
P
N
T
L
-
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------------
8
PsiBlast_PDB
76.37
36%
-87
- C2 -
1ECX
2
?
A:
[3-367]
--
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
-
E
M
-
I
-
V
F
Y
R
E--
K
-
Y
-
G
N
-
P
N
S
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
-----
A
E
T
-----
F
-----
E
K
R
K
-
R
T
I
I
-
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
K
G
F
K
V
K
Y
V
P
-
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
--
R
I
V
K
K
-----
K
----------
N
--
K
E
T
L
-
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
---
K
-------
G
--
V
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
----
L
R
S
K
L
V
S
G
L
M
N
L
G
A
H
I
I
--------
T
P
--
L
E
IS
L
P
N
T
L
-
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
---------------------
9
PsiBlast_PDB
76.26
36%
-89
- C2 -
1EG5
3
?
A:
[4-367]
---
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
-
E
M
-
I
-
V
F
Y
R
E--
K
-
Y
-
G
N
-
P
N
S
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
-----
A
E
T
-----
F
-----
E
K
R
K
-
R
T
I
I
-
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
K
G
F
K
V
K
Y
V
P
-
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
--
R
I
V
K
K
-----
K
----------
N
--
K
E
T
L
-
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
---
K
-------
G
--
V
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
----
L
R
S
K
L
V
S
G
-
L
M
N
L
G
A
H
I
I
T
P
L
E
-------
I
S
--
L
P
N
T
L
-
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
---------------------
3
PsiBlast_PDB
75.77
40%
-87
- C2 -
3LVK
1
ISCS_ECO57
A:
[25-400]
---
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
-
K
M
-
M
-
Q
F
M
T
MDG
T
-
F
-
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
-----
A
A
N
F
-----
Y
-----
Q
K
K
G
-
K
H
I
I
-
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
E
G
F
E
V
T
Y
L
A
-
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
--
E
M
C
R
A
-----
R
----------
G
--
I
I
---
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
---
R
-------
K
P
R
V
R
-------
I
E
A
Q
---
M
H
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
M
A
T
E
M
E
R
L
R
G
----
L
R
N
R
L
W
N
G
I
-
K
D
I
E
E
V
Y
L
N
G
-----
D
L
--
E
H
--
G
A
P
N
I
L
N
V
S
F
N
Y
V
E
--
G
E
S
L
I
M
A
L
--
K
D
L
A
V
S
S
G
S
A
C
-----
L
-
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
R
-----------
14
PsiBlast_PDB
73.28
32%
-84
- C2 -
3A9Z
5
SCLY_RAT
A:
[21-425]
---
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
-
A
V
-
T
E
A
M
K
E
---
A
-
W
-
G
N
-
P
S
S
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
--
V
R
C
F
H
E
-----
Q
Q
T
L
Q---
T
R
-
P
H
F
I
-
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
V
A
E
V
T
F
V
P
V
S
K
V
-
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
P
--
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
----------
G
--
L
P
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
-
P
R
I
G
A
L
Y
V
R
GVG
K
-------
L
--
T
P
-------
L
Y
P
M
---
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
----
I
R
D
Y
L
E
E
R
L
E
A
E
F
G
K
R
I
H
L
N
S
R
---
F
P
G
V
E
R
--
L
P
N
T
C
-
N
F
S
I
Q
G
S
Q
--
L
R
G
Y
M
V
L
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
-
E
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
---------------
30
PsiBlast_CBE
73.08
32%
-85
- C2 -
3A9Z
3
SCLY_RAT
B:
[21-425]
---
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
-
A
V
-
T
E
A
M
K
E
---
A
-
W
-
G
N
-
P
S
S
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
--
V
R
C
F
H
E
-----
Q
-------
T
R
-
P
H
F
I
-
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
V
A
E
V
T
F
V
P
V
S
K
V
-
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
P
--
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
----------
G
--
L
P
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
-
P
R
I
G
A
L
Y
V
R
GVG
K
-------
L
--
T
P
-------
L
Y
P
M
---
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
----
I
R
D
Y
L
E
E
R
L
E
A
E
F
G
K
R
I
H
L
N
S
R
---
F
P
GV
E
R
--
L
P
N
T
C
-
N
F
S
I
Q
G
S
Q
--
L
R
G
Y
M
V
L
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
-
E
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
---------------
31
PsiBlast_CBE
72.80
32%
-85
- C2 -
3A9Y
4
SCLY_RAT
B:
[21-425]
---
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
-
A
V
-
T
E
A
M
K
E
---
A
-
W
-
G
N
-
P
S
S
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
--
V
R
C
F
H
E
-----
Q
Q------
T
R
-
P
H
F
I
-
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
V
A
E
V
T
F
V
P
V
S
K
V
-
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
P
--
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
----------
G
--
L
P
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
-
P
R
I
G
A
L
Y
V
R
GVG
K
-------
L
--
T
P
-------
L
Y
P
M
---
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
----
I
R
D
Y
L
E
E
R
L
E
A
E
F
G
K
R
I
H
L
N
S
R
---
F
P
GV
E
R
--
L
P
N
T
C
-
N
F
S
I
Q
G
S
Q
--
L
R
G
Y
M
V
L
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
-
E
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
---------------
32
PsiBlast_CBE
72.28
32%
-83
- C2 -
3A9X
5
SCLY_RAT
B:
[21-425]
---
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
-
A
V
-
T
E
A
M
K
E
---
A
-
W
-
G
N
-
P
S
S
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
--
V
R
C
F
H
E
-----
Q
Q
T
L
Q---
T
R
-
P
H
F
I
-
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
V
A
E
V
T
F
V
P
V
S
K
V
-
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
P
--
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
----------
G
--
L
P
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
-
P
R
I
G
A
L
Y
V
R
GVG
K
-------
L
--
T
P
-------
L
Y
P
M
---
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
----
I
R
D
Y
L
E
E
R
L
E
A
E
F
G
K
R
I
H
L
N
S
R
---
F
P
G
V
E
R
--
L
P
N
T
C
-
N
F
S
I
Q
G
S
Q
--
L
R
G
Y
M
V
L
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
-
E
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
---------------
54
HHSearch
72.23
34%
-80
- C2 -
3A9Z
5
SCLY_RAT
A:
[19-430]
-
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
-
A
V
-
T
-
E
A
M
K
---
E
A
W
-
G
N
-
P
S
S
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
--
V
R
C
F
H
E
Q
Q
T
L
Q--------
T
R
-
P
H
F
I
-
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
V
A
E
V
T
F
V
P
-
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
--
R
R
I
K
A
-----
L
N
Q
I
R
A
A
S
GL
P
R
--
V
L
---
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
---
G
-------
V
--
G
K
-------
L
T
P
L
Y
P
M
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
----
I
R
D
Y
L
E
E
R
L
E
A
E
-
F
G
K
R
I
H
L
N
S
RFP
G
V
--
E
R
--
L
P
N
T
C
-
N
F
S
I
Q
G
S
Q
LR
G
Y
M
V
L
A
Q
--
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
D
-
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
----------
13
PsiBlast_PDB
71.05
32%
-81
- C2 -
3A9X
3
SCLY_RAT
A:
[21-425]
---
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
-
A
V
-
T
E
A
M
K
E
---
A
-
W
-
G
N
-
P
S
S
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
--
V
R
C
F
H
E
-----
Q
Q
T
L
Q
G
E
G
T
R
-
P
H
F
I
-
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
V
A
E
V
T
F
V
P
V
S
K
V
-
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
P
--
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
----------
G
--
L
P
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
-
P
R
I
G
A
L
Y
V
R
GVG
K
-------
L
--
T
P
-------
L
Y
P
M
---
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
----
I
R
D
Y
L
E
E
R
L
E
A
E
F
G
K
R
I
H
L
N
S
R
---
F
P
GV
E
R
--
L
P
N
T
C
-
N
F
S
I
Q
G
S
Q
--
L
R
G
Y
M
V
L
A
Q
C
Q
T
L
L
A
S
V
G
A
--------------------
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
---------------
51
HHSearch
70.31
36%
-88
- C2 -
3VAX
1
?
A:
[22-379]
--
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
-
I
V
-
L
-
H
W
M
T
---
A
E
F
-
G
N
-
A
G
S
R
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
G
L
--
A
P
Y
G
E
-------------
R
T
G
R
R
H
I
I
-
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
A
G
-
R
G
F
E
V
D
F
L
T
-
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
--
Q
Q
L
R
A
-----
T
----------
P
--
T
Y
---
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
T
T
-
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
---
R
-------
R
--
E
E
MDDERVP
L
E
P
I
---
M
F
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
A
E
H
A
Q
W
Q
V
A
A
Q
D
----
L
R
S
R
L
L
A
G
L
A
S
T
--
S
F
Q
V
N
G
D
Q
---
D
---
H
V
--
V
P
H
I
L
-
N
L
S
F
E
D
V
D
--
A
E
A
F
L
V
T
L
K
-
D
L
V
A
V
A
T
G
S
A
S
T
S
A
S
-
F
-
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------------
15
PsiBlast_PDB
69.99
36%
-90
- C2 -
3VAX
1
?
A:
[22-375]
--
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
-
H
-
W
M
T
A
---
E
-
F
-
G
N
-
A
G
S
R
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
G
L
A
P
Y
G
E
R
T
G
--------------
R
-
R
H
I
I
-
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
A
-
G
R
G
F
E
V
D
F
L
T
-
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
P
--
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
--
Q
Q
L
R
A
-----
T
----------
P
--
T
Y
---
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
-
T
T
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
---
R
R
EEMDDE
R
--
V
P
-------
L
E
P
I
---
M
F
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
----
F
E
A
E
H
A
Q
W
Q
V
A
A
Q
D
L
R
S
R
L
L
A
G
L
A
S
--
T
S
F
Q
V
N
G
D
Q
---
D
H
--
V
---
V
P
H
I
L
-
N
L
S
F
E
D
V
D
--
A
E
A
F
L
V
T
L
K
-
D
L
V
A
V
A
T
G
S
A
S
T
S
A
S
-
F
-
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
------------------------------------
33
PsiBlast_CBE
68.16
36%
-90
- C2 -
3VAX
2
?
B:
[22-375]
--
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
-
H
-
W
M
T
A
---
E
-
F
-
G
N
-
A
G
S
R
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
G
L
AP
Y
G
E
R
T
G
--------------
R
-
R
H
I
I
-
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
A
-
G
R
G
F
E
V
D
F
L
T
-
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
P
--
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
--
Q
Q
L
R
A
-----
T
----------
P
--
T
Y
---
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
-
T
T
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
---
R
REEMDDE
R
--
V
P
-------
L
E
P
I
---
M
F
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
----
F
E
A
E
H
A
Q
W
Q
V
AAQD
L
R
S
R
L
L
A
G
L
A
S
--
T
S
F
Q
V
N
G
D
Q
---
D
H
--
V
---
V
P
H
I
L
-
N
L
S
F
E
D
V
D
--
A
E
A
F
L
V
T
L
K
-
D
L
V
A
V
A
T
G
S
A
S
T
S
A
S
-
F
-
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
------------------------------------