@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3398c: (2016-05-19 )
MRGTDEKYGLPPQPDSDRMTRRTLPVLGLAHELITPTLRQMADRLDPHMRPVVSYHLGWSDERGRPVNNNCGKAIRPALVFVAAEAAGADPHSAIPGAVSVELVHNFSLVHDDLMDRDEHRRHRPTVWALWGDAMALLAGDAMLSLAHEVLLDCDSPHVGAALRAISEATRELIRGQAADTAFESRTDVALDECLKMAEGKTAALMAASAEVGALLAGAPRSVREALVAYGRHIGLAFQLVDDLLGIWGRPEITGKPVYSDLRSRKKTLPVTWTVAHGGSAGRRLAAWLVDETGSQTASDDELAAVAELIECGGGRRWASAEARRHVTQGIDMVARIGIPDRPAAELQDLAHYIVDRQA
Atome Classification :
(47 SA)
.........10.....-...20........30........40...---.-....50........60........70-.........80-........90-----.-----..-----......100.......110..--.....120.........130.......140.......150.-....-.-----.160--.-.--------------....--.-----------170-..-----.......180...--.------------..----------.190.......200...-....210......-.220-........230.......240.......250.......260.....-..270........280.----..-----.---....290....---...--.300......---.310.......320.......330.......340----.....-...350.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRGTDEKYGLPPQPDS-DR
M
T
R
RTL
P
V
L
G
L
A
H
E
L
I
T
P
T
L
R
Q
M
A
D
R---L-DPHM
R
P
V
V
S
Y
HLGWSDERGRPVNNN--C
G
K
A
I
R
P
A
L
V
F
-
V
A
AEAAGAD------P-----HS-----AIPG
A
V
S
V
E
L
V
HN
F
S
L
V
H
D
D
L--MD
R
D
E
H
--RRHRP
T
V
W
A
L
W
G
D
A
M
A
L
L
A
G
D
A
M
L
S
L
A
H
E
V
L
LD-CDSP-
H
-----
V
G
A
A
--
L
-
R
--------------
A
I
S
E
--
A
-----------
T
---
R
E
-----
L
I
RGQAADTAFES--R------------T
D
----------
V
A
L
D
E
C
L
K
MAEGK
T
A
A
L
-
M
AASAE
V
G
A
L
LAG-A
P
-
R
-
S
V
R
E
A
L
V
A
Y
G
R
HI
G
L
A
F
Q
L
V
D
D
L
L
G
IWGRPEITGK
P
V
Y
S
D
L
R
SRKK-TL
P
-
V
T
W
T
VAHGGSA-G----
R
R
-----
L
---
A
A
W
L
V-DETGS---QTA--S
D
D
E
L
A
A
V
A
E
---
L
I
E
CGGGRRW
A
S
A
E
A
R
R
H
V
T
Q
G
I
D
M
V
A
RIGIPD-----R
P
A
A
E
-
L
Q
D
L
A
H
Y
I
VDRQA
59
HHSearch
98.67
48%
-96
- C1 -
3NF2
6
?
A:
[4-341]
----------------------
D
V
T
A
L
L
E
R
G
R
T
L
A
T
P
V
L
R
A
A
V
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R
---
L
-
A
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P
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D
T
V
A
A
Y
H
F
G
W
I
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A
Q
G
N
P
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G
D
--
G
G
K
A
V
R
P
A
L
A
V
-
L
S
A
E
V
T
G
A
A
------
P
-----
E
V
-----
G
V
P
G
A
V
A
V
E
L
V
H
N
F
S
L
L
H
D
D
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--
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-
L
G
T
V
-
E
-----
A
G
R
A
--
T
-
R
--------------
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L
T
K
--
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-----------
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---
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S
-----
L
I
D
G
Q
A
Q
D
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Y
E
H
--
R
------------
D
R
----------
V
S
V
E
E
C
L
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M
E
G
N
K
T
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A
L
-
L
A
C
A
S
S
I
G
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V
L
G
G
-
A
D
-
E
-
R
T
A
D
T
L
E
K
Y
G
Y
H
L
G
L
A
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Q
A
V
D
D
L
L
G
I
W
G
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D
A
T
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T
W
S
D
L
R
Q
R
K
K
-
S
L
P
-
V
V
A
A
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G
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A
-
S
----
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R
-----
L
---
G
E
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-
A
D
A
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A
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A
N
F
--
S
E
E
E
F
A
A
R
A
A
---
L
I
E
E
A
G
G
R
E
W
T
A
D
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A
R
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Q
H
T
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A
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E
A
L
D
A
V
D
M
P
D
-----
R
V
R
D
R
-
F
T
A
L
A
D
F
V
V
V
---
1
PsiBlast_PDB
97.21
50%
-95
* C1 *
3NF2
6
?
A:
[15-341]
---------------------------------
L
A
T
P
V
L
R
A
A
V
D
R
---
L
-
A
P
P
M
D
T
V
A
A
Y
H
F
G
W
I
D
A
Q
G
N
P
A
D
G
D
--
G
G
K
A
V
R
P
A
L
A
V
-
L
S
A
E
V
T
G
A
A
------
P
-----
E
V
-----
G
V
P
G
A
V
A
V
E
L
V
H
N
F
S
L
L
H
D
D
L
--
M
D
G
D
E
Q
--
R
R
H
R
D
T
V
W
K
V
H
G
P
A
Q
A
I
L
V
G
D
A
L
F
A
L
A
N
E
V
L
L
E
-
L
G
T
V
-
E
-----
A
G
R
A
--
T
-
R
--------------
R
L
T
K
--
A
-----------
S
---
R
S
-----
L
I
D
G
Q
A
Q
D
I
S
Y
E
H
--
R
------------
D
R
----------
V
S
V
E
E
C
L
E
M
E
G
N
K
T
G
A
L
-
L
A
C
A
S
S
I
G
A
V
L
G
G
-
A
D
-
E
-
R
T
A
D
T
L
E
K
Y
G
Y
H
L
G
L
A
F
Q
A
V
D
D
L
L
G
I
W
G
D
P
D
A
T
G
K
Q
T
W
S
D
L
R
Q
R
K
K
-
S
L
P
-
V
V
A
A
L
A
A
G
G
A
A
-
S
----
E
R
-----
L
---
G
E
I
L
T
A
D
A
K
A
S
---
D
F
A
NF
S
E
E
E
F
A
A
R
A
A
---
L
I
E
E
A
G
G
R
E
W
T
A
D
E
A
R
R
Q
H
T
I
A
I
E
A
L
D
A
V
D
M
P
D
-----
R
V
R
D
R
-
F
T
A
L
A
D
F
V
V
V
---
62
HHSearch
76.12
32%
-93
- C1 -
1WY0
2
?
A:
[3-341]
-------------------
K
Y
E
E
L
F
A
R
I
K
E
K
A
K
L
I
D
E
K
I
F
E
L
I
P
E
---
K
D
P
R
V
L
Y
E
A
A
R
H
Y
-----------
P
L
A
--
G
G
K
R
V
R
P
F
V
V
L
-
T
S
T
E
A
V
G
G
D
------
P
-----
L
R
-----
A
I
Y
P
A
V
A
I
E
L
I
H
N
Y
S
L
V
H
D
D
I
--
M
D
M
D
E
T
--
R
R
G
K
P
T
V
H
R
I
W
G
V
N
M
A
I
L
A
G
D
L
L
F
S
K
A
F
E
A
V
A
R
-
A
E
I
P
-
P
E
K
---
K
A
R
V
--
L
-
E
--------------
V
I
V
K
--
A
-----------
S
---
N
E
-----
L
C
E
G
Q
A
R
D
L
E
F
E
K
--
K
------------
S
T
----------
V
T
I
E
E
Y
M
E
M
I
S
G
K
T
G
A
L
-
F
E
A
S
A
K
V
G
G
I
I
G
T
-
D
N
-
E
-
E
Y
I
K
A
L
S
S
W
G
R
N
V
G
I
A
F
Q
I
W
D
D
V
L
D
L
I
A
D
E
K
K
L
G
K
P
V
G
S
D
I
R
K
G
K
K
-
T
L
I
-
V
A
H
F
F
E
N
A
D
E
K
-
D
K
---
Q
R
-----
F
---
L
K
I
F
G
-
K
---------
D
--
I
K
S
D
V
M
E
A
I
D
---
L
L
K
K
Y
G
S
I
D
Y
A
A
E
I
A
K
D
M
I
K
K
A
N
E
A
L
R
I
L
P
K
S
------
K
A
R
M
D
-
L
E
L
L
A
K
F
I
V
E
R
E
-
67
HHSearch
71.01
32%
-89
- C1 -
4DHD
3
?
A:
[12-334]
-----------------------------
K
Y
G
A
E
V
E
K
A
L
V
R
Y
L
S
I
---
G
L
A
E
D
F
R
E
A
V
L
Y
Q
-----------
V
K
T
--
G
G
K
R
L
R
P
L
L
T
L
-
A
A
A
E
A
V
S
G
Q
------
W
-----
R
P
-----
A
L
P
A
A
A
I
V
E
L
I
H
N
Y
S
L
I
Y
D
D
I
--
I
D
R
G
D
V
--
R
R
G
L
P
T
V
R
K
A
F
G
D
N
A
A
I
L
V
G
I
W
Y
R
E
A
I
E
E
A
V
L
D
-
T
P
K
--------
P
T
L
F
--
A
-
K
--------------
E
V
A
E
--
V
-----------
I
---
K
A
-----
I
D
E
G
E
R
L
D
I
L
F
E
A
--
A
GRSD
P
Y
F
V
Q
A
RW
R
E
----------
V
T
L
D
D
Y
I
K
M
V
S
L
K
T
G
A
L
-
I
A
A
A
A
K
W
G
V
L
S
V
S
-
D
D
-
R
-
G
L
A
E
A
A
W
N
F
G
M
A
A
G
V
A
F
Q
I
I
D
D
V
L
D
I
Y
G
-------
E
I
G
K
D
I
K
E
H
K
R
-
G
N
A
V
V
A
V
A
L
S
H
L
G
E
G
E
R
----
R
R
-----
L
---
L
E
I
L
A
-
R
E
-------
V
V
--
E
E
A
D
V
R
E
A
V
A
---
L
L
D
S
V
G
A
R
E
E
A
L
R
L
A
A
R
Y
R
E
E
A
E
R
H
L
A
K
I
P
N
N
---------
G
T
-
L
K
E
L
L
D
F
I
V
A
R
--
2
PsiBlast_PDB
68.34
37%
-91
- C1 -
1WY0
2
?
A:
[46-341]
------------------------------------------------------------------------------
G
K
R
V
R
P
F
V
V
L
-
T
S
T
E
A
V
G
G
D
------
P
-----
L
R
-----
A
I
Y
P
A
V
A
I
E
L
I
H
N
Y
S
L
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H
D
D
I
--
M
D
M
D
E
T
--
R
R
G
K
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H
R
I
W
G
V
N
M
A
I
L
A
G
D
L
L
F
S
K
A
F
E
A
V
A
R
-
A
E
I
P
-
P
-----
E
K
K
A
R
V
L
-
E
--------------
V
I
V
K
--
A
-----------
S
---
N
E
-----
L
C
E
G
Q
A
R
D
L
E
F
E
K
--
K
------------
S
T
----------
V
T
I
E
E
Y
M
E
M
I
S
G
K
T
G
A
L
-
F
E
A
S
A
K
V
G
G
I
I
G
T
-
D
N
-
E
-
E
Y
I
K
A
L
S
S
W
G
R
N
V
G
I
A
F
Q
I
W
D
D
V
L
D
L
I
A
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K
K
L
G
K
P
V
G
S
D
I
R
K
G
K
K
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L
I
-
V
A
H
F
F
E
N
A
D
E
K
-
D
----
K
Q
R
F
L
K
I
F
---
G
K
-------------------
D
I
K
S
D
V
M
E
A
I
D
L
L
K
K
Y
G
S
I
D
Y
A
-
A
E
I
A
K
D
M
I
K
K
A
N
E
A
L
R
I
L
P
K
S
-----
K
A
R
M
D
-
L
E
L
L
A
K
F
I
V
E
R
E
-
5
PsiBlast_PDB
67.58
32%
-79
- C1 -
4GP2
5
?
A:
[45-335]
------------------------------------------------------------------------------
G
K
R
L
R
P
L
L
T
L
-
A
A
A
E
A
V
S
G
Q
------
W
-----
R
P
-----
A
L
P
A
A
A
I
V
E
L
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N
Y
S
L
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D
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--
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D
R
G
D
V
--
R
R
G
L
P
T
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A
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N
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A
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W
Y
R
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A
I
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A
V
L
D
-
T
P
K
P
-
T
-----
L
F
A
-----
K
--------------
E
V
A
E
--
V
-----------
I
---
K
A
-----
I
D
E
G
E
R
L
D
I
L
F
E
A
AG
R
------------
S
D
P
Y
F
V
Q
A
RWRE
V
T
L
D
D
Y
I
K
M
V
S
L
K
T
G
A
L
-
I
A
A
A
A
K
W
G
V
L
S
V
S
-
D
D
-
R
-
G
L
A
E
A
A
W
N
F
G
M
A
A
G
V
A
F
Q
I
I
D
D
V
L
D
I
Y
G
D
P
K
K
F
G
K
E
I
G
K
D
I
K
E
H
K
R
G
N
A
V
-
V
A
V
A
L
S
H
L
G
E
G
-
E
----
R
R
-----
R
------
L
L
-
E
I
L
A
R
---
E
V
V
--
E
E
A
D
V
R
E
A
V
A
---
L
L
D
S
V
G
A
R
E
E
A
L
R
L
A
A
R
Y
R
E
E
A
E
R
H
L
A
K
--
I
P
N
-----
N
--
G
T
-
L
K
E
L
L
D
F
I
V
A
R
E
-
21
PsiBlast_CBE
67.28
32%
-81
- C1 -
4GP2
5
?
B:
[45-335]
------------------------------------------------------------------------------
G
K
R
L
R
P
L
L
T
L
-
A
A
A
E
A
V
S
G
Q
------
W
-----
R
P
-----
A
L
P
A
A
A
I
V
E
L
I
H
N
Y
S
L
I
Y
D
D
I
--
I
D
R
G
D
V
--
R
R
G
L
P
T
V
R
K
A
F
G
D
N
A
A
I
L
V
G
I
W
Y
R
E
A
I
E
E
A
V
L
D
-
T
P
K
P
-
T
-----
L
F
A
-----
K
--------------
E
V
A
E
--
V
-----------
I
---
K
A
-----
I
D
E
G
E
R
L
D
I
L
F
E
A
AG
R
------------
S
D
P
Y
F
V
Q
A
RWRE
V
T
L
D
D
Y
I
K
M
V
S
L
K
T
G
A
L
-
I
A
A
A
A
K
W
G
V
L
S
V
S
-
D
D
-
R
-
G
L
A
E
A
A
W
N
F
G
M
A
A
G
V
A
F
Q
I
I
D
D
V
L
D
I
Y
G
D
------
E
I
G
K
D
I
K
E
H
K
R
G
N
A
V
-
V
A
V
A
L
S
H
L
G
E
G
-
E
----
R
R
-----
R
------
L
L
-
E
I
L
A
R
---
E
V
V
--
E
E
A
D
V
R
E
A
V
A
---
L
L
D
S
V
G
A
R
E
E
A
L
R
L
A
A
R
Y
R
E
E
A
E
R
H
L
A
K
--
I
P
N
-----
N
--
G
T
-
L
K
E
L
L
D
F
I
V
A
R
E
-
56
HHSearch
67.17
26%
-95
- C1 -
4LOB
4
?
A:
[31-346]
-----------------------
I
L
A
P
V
A
T
D
F
A
A
M
D
H
L
I
N
E
G
I
S
S
---
K
-
V
G
L
V
M
S
V
S
K
H
V
V
-----------
E
A
--
G
G
K
R
M
R
P
I
M
C
L
-
L
A
A
R
A
C
D
L
D
N-----
M
-----
Q
N
-----
A
Q
R
L
A
A
I
I
E
M
L
H
T
A
T
L
V
H
D
D
V
--
V
D
----------------
W
N
N
Q
T
A
V
L
V
G
D
F
L
I
A
R
A
F
D
L
L
V
D
-
L
N
N
---------
M
T
L
--
L
-
K
--------------
D
F
S
T
--
G
-----------
T
---
C
E
-----
I
A
E
G
E
V
L
Q
L
Q
S
Q
H
--
Q
------------
P
D
----------
T
T
E
E
T
Y
L
K
I
I
H
G
K
T
S
R
L
-
F
E
L
A
T
E
G
A
A
I
L
A
G
-
Q
E
-
A
--
Y
R
E
P
L
R
L
F
A
G
H
F
G
N
A
F
Q
I
I
D
D
I
L
D
Y
T
S
D
A
E
T
L
G
K
N
I
G
D
D
L
M
E
G
K
P
-
T
L
P
-
L
I
S
A
L
A
H
S
T
G
E
-
E
H
---
A
I
-----
I
---
R
R
S
I
A
-
T
G
-----------
G
V
D
Q
L
P
K
V
I
E
---
I
V
Q
K
S
G
A
L
D
Y
C
Q
R
R
A
Q
E
E
T
E
A
A
L
Q
A
L
S
I
L
P
D
T
------
P
Y
R
Q
A
-
L
I
N
L
T
R
L
A
L
H
R
I
-
61
HHSearch
66.82
25%
-95
- C1 -
3APZ
-
SPS3_ARATH
A:
[10-347]
-----------------------
P
F
S
L
V
A
D
E
L
S
L
L
S
N
K
L
R
E
M
V
L
A
---
E
-
V
P
-----------------------GV
Q
G
K
Q
F
R
S
T
I
L
L
-
L
M
A
T
A
L
D
V
--------T
S
E
L
R
V
R
-----
Q
R
G
I
A
E
I
T
E
M
I
H
V
A
S
L
L
H
D
D
--------------------
V
M
G
N
K
M
S
V
L
A
G
D
F
L
L
S
R
A
C
G
A
L
A
A
-
L
K
N
---------
T
E
V
--
V
-
A
--------------
L
L
A
T
--
A
-----------
V
---
E
H
-----
L
V
T
G
E
T
M
E
I
T
S
S
T
--
E
------------
Q
R
----------
Y
S
M
D
Y
Y
M
Q
K
T
Y
Y
K
T
A
S
L
-
I
S
N
S
C
K
A
V
A
V
L
T
G
-
Q
T
-
A
-
E
V
A
V
L
A
F
E
Y
G
R
N
L
G
L
A
F
Q
L
I
D
D
I
L
D
F
T
G
T
S
A
S
L
G
K
G
S
L
S
D
I
R
H
G
V
I
-
T
A
P
-
I
L
F
A
M
E
E
F
P
Q
--------------
L
---
R
E
V
V
D
-
Q
V
-------
E
K
--
D
P
R
N
V
D
I
A
L
E
---
Y
L
G
K
S
K
G
I
Q
R
A
R
E
L
A
M
E
H
A
N
L
A
A
A
A
I
G
S
L
P
E
T
D
N
E
D
V
K
R
S
R
R
A
-
L
I
D
L
T
H
R
V
I
T
R
N
-
3
PsiBlast_PDB
66.51
32%
-79
- C1 -
4DHD
3
?
A:
[45-335]
------------------------------------------------------------------------------
G
K
R
L
R
P
L
L
T
L
-
A
A
A
E
A
V
S
G
Q
------
W
-----
R
P
-----
A
L
P
A
A
A
I
V
E
L
I
H
N
Y
S
L
I
Y
D
D
I
--
I
D
R
G
D
V
--
R
R
G
L
P
T
V
R
K
A
F
G
D
N
A
A
I
L
V
G
I
W
Y
R
E
A
I
E
E
A
V
L
D
-
T
P
K
P
-
T
-----
L
F
A
-----
K
--------------
E
V
A
E
--
V
-----------
I
---
K
A
-----
I
D
E
G
E
R
L
D
I
L
F
E
A
AG
R
------------
S
D
P
Y
F
V
Q
A
RWRE
V
T
L
D
D
Y
I
K
M
V
S
L
K
T
G
A
L
-
I
A
A
A
A
K
W
G
V
L
S
V
S
-
D
D
-
R
-
G
L
A
E
A
A
W
N
F
G
M
A
A
G
V
A
F
Q
I
I
D
D
V
L
D
I
Y
G
-------
E
I
G
K
D
I
K
E
H
K
R
G
N
A
V
-
V
A
V
A
L
S
H
L
G
E
G
-
E
----
R
R
-----
R
------
L
L
-
E
I
L
A
R
---
E
V
V
--
E
E
A
D
V
R
E
A
V
A
---
L
L
D
S
V
G
A
R
E
E
A
L
R
L
A
A
R
Y
R
E
E
A
E
R
H
L
A
K
--
I
P
N
-----
N
--
G
T
-
L
K
E
L
L
D
F
I
V
A
R
E
-
66
HHSearch
66.00
31%
-89
- C1 -
3LK5
1
?
A:
[57-370]
-----------------------------------------------------------------------
F
V
L
N
--
G
G
K
R
I
R
P
L
Y
A
W
-
A
G
F
L
A
A
Q
G
H
KNSSEK
L
-----
E
S
-----
V
L
D
A
A
A
S
L
E
F
I
Q
A
C
A
L
I
H
D
D
I
--
I
D
S
---------------
F
G
V
S
V
S
I
L
A
G
D
M
A
L
V
W
A
E
D
M
L
Q
D
-
S
G
L
S
-
A
E
A
---
L
A
R
T
--
R
-
D
--------------
A
W
R
G
--
M
-----------
R
---
T
E
-----
V
I
G
G
Q
L
L
D
I
Y
L
E
S
--
H
------------
A
N
----------
E
S
V
E
L
A
D
S
V
N
R
F
K
T
A
A
Y
T
I
A
R
P
L
H
L
G
A
S
I
A
G
-
G
S
-
P
-
Q
L
I
D
A
L
L
H
Y
G
H
D
I
G
I
A
F
Q
L
R
D
D
L
L
G
V
F
G
D
P
A
I
T
G
K
P
A
G
D
D
I
R
E
G
K
R
-
T
V
L
-
L
A
L
A
L
Q
R
A
D
K
Q
-
S
P
E
A
A
T
A
-----
I
---
R
A
G
V
G
-
K
--------
V
T
--
S
P
E
D
I
A
V
I
T
E
---
H
I
R
A
T
G
A
E
E
E
V
E
Q
R
I
S
Q
L
T
E
S
G
L
A
H
L
D
D
V
D
I
P
D
-----
E
V
R
A
Q
-
L
R
A
L
A
I
R
S
T
E
---
4
PsiBlast_PDB
65.95
32%
-79
- C1 -
4GP1
3
?
A:
[45-335]
------------------------------------------------------------------------------
G
K
R
L
R
P
L
L
T
L
-
A
A
A
E
A
V
S
G
Q
------
W
-----
R
P
-----
A
L
P
A
A
A
I
V
E
L
I
H
N
Y
S
L
I
Y
D
D
I
--
I
D
R
G
D
V
--
R
R
G
L
P
T
V
R
K
A
F
G
D
N
A
A
I
L
V
G
I
W
Y
R
E
A
I
E
E
A
V
L
D
-
T
P
K
P
-
T
-----
L
F
A
-----
K
--------------
E
V
A
E
--
V
-----------
I
---
K
A
-----
I
D
E
G
E
R
L
D
I
L
F
E
A
AG
R
------------
S
D
P
Y
F
V
Q
A
RWRE
V
T
L
D
D
Y
I
K
M
V
S
L
K
T
G
A
L
-
I
A
A
A
A
K
W
G
V
L
S
V
S
-
D
D
-
R
-
G
L
A
E
A
A
W
N
F
G
M
A
A
G
V
A
F
Q
I
I
D
D
V
L
D
I
Y
G
-------
E
I
G
K
D
I
K
E
H
K
R
G
N
A
V
-
V
A
V
A
L
S
H
L
G
E
G
-
E
----
R
R
-----
R
------
L
L
-
E
I
L
A
R
---
E
V
V
--
E
E
A
D
V
R
E
A
V
A
---
L
L
D
S
V
G
A
R
E
E
A
L
R
L
A
A
R
Y
R
E
E
A
E
R
H
L
A
K
--
I
P
N
-----
N
--
G
T
-
L
K
E
L
L
D
F
I
V
A
R
E
-
60
HHSearch
65.89
27%
-83
- C1 -
3LMD
-
?
A:
[34-349]
-----------------------
L
T
A
R
I
N
D
A
M
V
Q
V
E
E
L
L
H
T
E
L
S
S
---
G
-
E
D
F
L
V
D
I
V
M
H
L
T
-----------
R
A
--
G
G
K
R
F
R
P
M
F
A
L
-
L
A
S
E
F
G
E
K
P
L-----
S
-----
E
N
-----
V
I
K
A
A
V
V
V
E
I
T
H
L
A
T
L
Y
H
D
D
V
--
M
D
-------------
N
A
R
W
D
N
S
V
A
I
L
A
G
D
I
L
L
A
H
A
S
G
L
M
S
Q
-
L
G
----------
T
D
T
--
V
-
A
--------------
H
F
A
E
--
T
-----------
F
---
G
E
-----
L
V
T
G
Q
M
R
E
T
V
G
P
R
--
D
-------------
T
----------
D
P
I
E
H
Y
T
N
V
I
R
E
K
T
G
V
L
-
I
A
S
A
G
Y
L
G
A
M
H
A
G
-
A
A
-
P
-
E
H
I
D
A
L
K
N
F
G
A
A
V
G
M
I
F
Q
I
V
D
D
I
I
D
I
F
S
--------
P
G
T
D
L
R
E
G
V
F
-
T
L
P
-
V
L
Y
A
L
R
E
D
T
P
V
-
G
----
A
E
-----
L
---
R
D
I
L
T
-
G
P
-------
L
E
--
D
D
E
T
V
N
H
V
L
E
---
L
L
S
Q
S
G
G
R
Q
A
A
L
D
E
V
Y
R
Y
M
D
I
A
N
A
E
L
D
R
L
P
D
S
------
T
V
K
E
A
-
L
R
N
L
A
T
F
T
V
K
R
V
-
63
HHSearch
65.83
26%
-85
- C1 -
3PKO
2
?
A:
[16-333]
----------------------
R
Q
F
P
Q
V
E
P
Q
L
T
A
L
Q
D
Y
L
L
R
T
V
Q
L
---
D
-
N
Q
P
I
H
H
K
I
L
A
L
-----------
L
K
S
--
G
G
K
L
L
R
P
G
Y
F
Y
-
L
F
S
T
F
G
N
A
A
T-----
P
-----
A
Q
-----
L
Q
A
G
A
A
A
I
E
I
L
H
V
G
T
L
I
H
D
D
V
--
I
D
D
S
P
T
--
R
R
G
V
R
T
I
Q
M
T
Y
G
Q
R
N
A
I
Y
A
G
D
F
M
F
T
V
Y
F
D
Q
V
L
K
-
S
T
T
--------
D
R
S
L
--
I
-
Q
--------------
N
H
I
D
--
A
-----------
M
---
H
R
-----
I
L
Q
G
E
L
H
Q
M
D
L
N
Y
--
R
------------
E
D
----------
I
T
L
D
A
Y
L
N
E
I
A
G
K
T
A
E
L
-
F
A
L
S
C
Y
Q
G
A
Q
L
A
G
-
A
P
-
Q
-
S
V
I
D
R
T
R
D
I
G
I
A
I
G
C
A
Y
Q
M
L
D
D
I
L
D
Y
A
G
D
P
K
R
T
Q
K
P
V
L
E
D
L
R
S
G
V
Y
-
S
L
P
-
L
L
L
S
L
S
H
A
P
R
--------
D
-----
F
---
H
K
L
L
K
-
K
K
------
Q
A
M
--
T
L
E
D
I
K
H
V
Q
A
---
L
V
A
Q
Y
D
G
V
G
A
A
K
Q
L
A
Q
D
Y
T
D
R
A
L
T
L
I
Q
Q
L
P
V
G
------
S
A
Q
Q
S
-
L
E
Q
L
T
R
L
L
L
R
R
D
-
13
PsiBlast_PDB
65.73
30%
-84
- C1 -
3WJO
2
?
A:
[47-333]
-----------------------------------------------------------------
N
Q
L
G
Y
Y
I
V
S
G
--
G
G
K
R
I
R
P
M
I
A
V
-
L
A
A
R
A
V
G
Y
E
------
G
-----
N
A
-----
H
V
T
I
A
A
L
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
D
M
--
R
R
G
K
A
T
A
N
A
A
F
G
N
A
A
S
V
L
V
G
D
F
I
Y
T
R
A
F
Q
M
M
T
S
-
L
G
S
L
-
K
-----
V
-----
L
-
E
--------------
V
M
S
E
--
A
-----------
V
---
N
V
-----
I
A
E
G
E
V
L
Q
L
M
N
---------------------------------
N
Y
M
R
V
I
Y
S
K
T
A
R
L
-
F
E
A
A
A
Q
C
S
G
I
L
A
G
-
C
T
-
P
-
E
E
E
K
G
L
Q
D
Y
G
R
Y
L
G
T
A
F
Q
L
I
D
D
L
L
D
Y
N
A
--------
V
G
D
D
L
N
E
G
K
P
-
T
L
P
-
L
L
H
A
M
H
H
G
T
P
E
-----------------
Q
A
Q
M
I
-
R
T
A
I
E
---
Q
G
N
--
G
R
H
L
L
E
P
V
L
E
---
A
M
N
A
C
G
S
L
E
W
T
R
Q
R
A
E
E
E
A
D
K
A
I
--
A
A
L
Q
V
L
P
D
-----
T
P
W
R
E
A
L
I
G
L
A
H
I
A
V
----
15
PsiBlast_PDB
65.17
27%
-82
- C1 -
4JYX
4
?
A:
[43-345]
-----------------------------------------------------
I
Q
K
Q
V
N
S
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
--
G
G
K
R
L
R
P
L
L
T
V
-
L
A
A
R
A
L
N
I
Q
------
T
-----
E
Q
-----
H
H
T
L
A
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
T
M
--
R
R
G
R
E
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
M
M
V
T
-
L
D
S
M
-
R
-----
V
-----
M
-
Q
--------------
I
L
S
D
--
A
-----------
T
---
N
V
-----
I
A
E
G
E
V
L
Q
L
M
N
C
N
--
D
------------
P
D
----------
T
T
E
E
S
Y
M
E
V
I
Y
S
K
T
A
R
L
-
F
E
A
A
T
L
L
A
G
V
L
T
K
-
Q
S
-
E
-
A
I
E
N
A
M
Q
D
Y
G
K
Y
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
S
-------
N
M
G
D
D
L
A
E
G
K
P
-
T
L
P
-
L
L
Y
A
M
W
H
G
N
E
Q
-
Q
----
T
A
-----
I
---
I
R
E
A
I
--
E
T
G
N
---
G
M
-----
D
N
L
T
P
I
L
E
---
T
M
E
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
-----
Y
K
E
A
--
L
I
G
L
A
H
I
S
V
E
R
V
A
58
HHSearch
64.98
23%
-87
- C1 -
3AQB
3
HEXB_MICLU
B:
[6-324]
-----------------------
Y
K
A
F
L
N
P
Y
I
I
E
V
E
K
R
L
Y
E
C
I
Q
S
---
D
-
S
E
T
I
N
K
A
A
H
H
I
L
-----------
S
S
--
G
G
K
R
V
R
P
M
F
V
L
-
L
S
G
F
L
N
D
T
Q
------
K
-----
D
D
-----
L
I
R
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
D
D
Y
--
I
D
N
S
D
M
--
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
N
I
A
T
-
I
N
N
---------
S
K
F
--
H
-
Q
--------------
I
F
S
K
--
T
-----------
I
---
L
E
-----
V
C
F
G
E
F
D
Q
M
A
D
R
F
--
N
------------
Y
P
----------
V
S
F
T
A
Y
L
R
R
I
N
R
K
T
A
I
L
-
I
E
A
S
C
H
L
G
A
L
S
S
Q
-
L
D
-
E
-
Q
S
T
Y
H
I
K
Q
F
G
H
C
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
-
T
Y
P
-
L
M
A
A
I
A
N
L
K
E
Q
-
D
D---
D
K
-----
L
---
E
A
V
V
K
-
H
L
T
-----
S
T
S
--
D
D
E
V
Y
Q
Y
I
V
S
---
Q
V
K
Q
Y
G
-
I
E
P
A
E
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
------
N
I
K
D
Y
-
L
E
E
I
H
E
K
M
L
K
R
V
-
19
PsiBlast_PDB
64.75
32%
-78
- C1 -
3Q2Q
5
?
A:
[74-350]
------------------------------------------------------------------------------
G
K
R
F
R
P
M
F
A
L
-
L
A
S
E
F
-
G
E
K
------
P
-----
L
S
E
N
---
V
I
K
A
A
V
V
V
E
I
T
H
L
A
T
L
Y
H
D
D
V
--
M
D
E
A
---------
S
A
N
A
R
W
D
N
S
V
A
I
L
A
G
D
I
L
L
A
H
A
S
G
L
M
S
Q
-
L
G
T
D
-
T
-----
V
A
H
---------------------
F
A
E
--
T
-----------
F
---
G
E
-----
L
V
T
G
Q
M
R
E
T
V
G
P
R
--
D
------------
T
D
-----------
P
I
E
H
Y
T
N
V
I
R
E
K
T
G
V
L
-
I
A
S
A
G
Y
L
G
A
M
H
A
G
-
A
A
-
P
-
E
H
I
D
A
L
K
N
F
G
A
A
V
G
M
I
F
Q
I
V
D
D
I
I
D
I
F
S
E
T
H
----
T
P
G
T
D
L
R
E
G
V
F
-
T
L
P
-
V
L
Y
A
L
R
E
D
T
P
V
-
G
----------------
A
E
L
R
-
D
I
L
T
G
---
P
L
E
--
D
D
E
T
V
N
H
V
L
E
---
L
L
S
Q
S
G
G
R
Q
A
A
L
D
E
V
Y
R
Y
M
D
I
A
N
A
E
L
D
R
--
L
P
D
-----
S
T
V
K
E
A
L
R
N
L
A
T
F
T
V
K
R
--
53
HHSearch
64.54
25%
-92
- C1 -
4JXY
2
?
A:
[28-345]
-----------------------
I
L
S
L
A
E
P
D
M
L
A
V
N
Q
L
I
Q
K
Q
V
N
S
---
D
-
V
S
L
I
N
Q
L
G
F
Y
I
V
-----------
N
S
--
G
G
K
R
L
R
P
L
L
T
V
-
L
A
A
R
A
L
N
I
Q
------
T
-----
E
Q
-----
H
H
T
L
A
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
-----------
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
M
M
V
T
-
L
D
S
---------
M
R
V
--
M
-
Q
--------------
I
L
S
D
--
A
-----------
T
---
N
V
-----
I
A
E
G
E
V
L
Q
L
M
N
C
N
--
D
------------
P
D
----------
T
T
E
E
S
Y
M
E
V
I
Y
S
K
T
A
R
L
-
F
E
A
A
T
L
L
A
G
V
L
T
K
-
Q
S
-
E
-
A
I
E
N
A
M
Q
D
Y
G
K
Y
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
----------
G
D
D
L
A
E
G
K
P
-
T
L
P
-
L
L
Y
A
M
W
H
G
N
E
Q
-
Q
T
---
A
I
-----
I
---
R
E
A
I
E
-
T
G
--------
N
--
G
M
D
N
L
T
P
I
L
E
---
T
M
E
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
------
V
Y
K
E
A
-
L
I
G
L
A
H
I
S
V
E
R
V
A
14
PsiBlast_PDB
64.08
28%
-77
- C1 -
4LOB
3
?
A:
[24-330]
--------------------------
V
I
D
F
K
Q
D
I
L
A
P
V
A
T
D
F
A
-
A
---
M
-
D
H
L
I
N
E
G
I
S
S
K
V
G
L
V
M
S
V
S
K
H
V
V
E
A
--
G
G
K
R
M
R
P
I
M
C
L
-
L
A
A
R
A
C
D
L
D
------
N
M----
Q
N
-----
A
Q
R
L
A
A
I
I
E
M
L
H
T
A
T
L
V
H
D
D
V
--
V
D
----------------
W
N
N
Q
T
A
V
L
V
G
D
F
L
I
A
R
A
F
D
L
L
V
D
-
L
N
N
M
-
T
-----
L
-----
L
-
K
--------------
D
F
S
T
--
G
-----------
T
---
C
E
-----
I
A
E
G
E
V
L
Q
L
Q
S
Q
H
--
Q
------------
P
D
----------
T
T
E
E
T
Y
L
K
I
I
H
G
K
T
S
R
L
-
F
E
L
A
T
E
G
A
A
I
L
A
G
--
Q
-
E
-
A
Y
R
E
P
L
R
L
F
A
G
H
F
G
N
A
F
Q
I
I
D
D
I
L
D
Y
T
S
D
A
E
T
L
G
K
N
I
G
D
D
L
M
E
G
K
P
-
T
L
P
-
L
I
S
A
L
A
H
--
S
T
-
G
----
E
E
-----
H
---
A
---
I
-
I
R
R
S
I
---
A
T
G
--
G
V
D
Q
L
P
K
V
I
E
---
I
V
Q
K
S
G
A
L
D
Y
C
Q
R
R
A
Q
E
E
T
E
A
A
L
Q
A
L
S
I
--
L
P
D
-----
T
P
-----------------
75
HHSearch
59.83
30%
-78
- C1 -
1RQJ
5
ISPA_ECOLI
A:
[3-298]
-----------------------
F
P
Q
Q
L
E
A
C
V
K
Q
A
N
Q
A
L
S
R
F
I
A
P
LPF
Q
-
N
T
P
V
V
E
T
M
Q
Y
G
-----------
A
L
L
--
G
G
K
R
L
R
P
F
L
V
Y
-
A
T
G
H
M
F
G
V
S
------
T
-----
N
T
-----
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
PA
M
D
D
D
D
L
--
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
D
-
A
D
M
P
-
E
VS
D
R
D
R
I
S
M
--
I
-
S
--------------
E
L
A
S
A
S
G
-----------
I
---
A
G
-----
M
C
G
G
Q
A
L
D
L
D
A
E
G
--
K
-------------
H
----------
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
-
I
R
A
A
V
R
L
G
A
L
S
A
G
-
D
K
-
G
R
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
-
T
Y
P
-
A
L
L
G
L
E
Q
A
R
K
---------------------------------------------------------------
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
A
E
Q
S
-----
L
D
T
S
A
-
L
E
A
L
A
D
Y
I
I
Q
R
N
-
37
PsiBlast_CBE
54.22
34%
-73
- C1 -
1RQJ
5
ISPA_ECOLI
B:
[44-294]
------------------------------------------------------------------------------
G
K
R
L
R
P
F
L
V
Y
-
A
T
G
H
M
F
G
V
S
------
T
-----
N
T
-----
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
--
P
A
M
D
D
D
DL
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
D
-
A
D
M
P
-
E
-----
V
S
D
R
--
D
-
R
I
S
------------
M
I
S
E
--
L
-----------
A
---
S
A
S
G
I
AG
M
C
G
G
Q
A
L
D
L
D
A
E
G
--
K
-------------
H
----------
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
-
I
R
A
A
V
R
L
G
A
L
S
A
G
D
K
G
-
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
-
T
Y
P
-
A
L
L
G
L
E
Q
A
R
K
K
-
A
----
R
D
-----
L
I
D
D
A
R
Q
S
L
-
K
Q
L
A
E
---
Q
S
L
--
D
T
S
A
L
E
A
L
A
D
---
Y
I
-------------------------------------------------------
27
PsiBlast_CBE
53.93
31%
-72
- C1 -
3OYR
4
?
B:
[18-269]
----------
P
R
K
S
G
S
V
D
R
L
V
R
L
A
E
A
D
M
A
G
V
N
R
L
I
T
D
R
M
Q
S
---------
D
V
A
I
I
P
A
L
A
E
H
L
I
A
A
------------
G
G
K
R
L
R
P
L
M
T
V
-
A
A
A
R
L
A
G
A
D
------
N
-----
D
H
-----
F
Q
K
L
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
G
S
Q
L
--
R
R
G
K
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
L
M
V
E
-
T
N
S
M
-
K
--------
A
--
L
-
E
--------------
I
L
A
R
--
A
-----------
S
---
R
V
-----
I
A
E
G
E
V
L
Q
L
M
R
S
H
--
D
------------
L
N
----------
L
S
Q
A
V
Y
L
E
I
I
Q
A
K
T
A
E
L
-
F
A
A
A
S
E
A
G
A
V
S
A
G
-
V
D
-
V
-
A
K
S
E
A
L
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
G
G
A
T
E
T
L
G
K
N
A
G
D
D
F
R
E
G
K
A
-
T
L
P
-
L
L
L
A
I
A
R
S
G
------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
53.59
34%
-70
- C1 -
1RQJ
5
ISPA_ECOLI
A:
[44-294]
------------------------------------------------------------------------------
G
K
R
L
R
P
F
L
V
Y
-
A
T
G
H
M
F
G
V
S
------
T
-----
N
T
-----
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
--
P
A
M
D
D
D
DL
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
D
-
A
D
M
P
-
E
-----
V
S
D
R
--
D
-
R
I
S
------------
M
I
S
E
--
L
-----------
A
---
S
A
S
G
I
AG
M
C
G
G
Q
A
L
D
L
D
A
E
G
--
K
-------------
H
----------
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
-
I
R
A
A
V
R
L
G
A
L
S
A
G
D
K
G
-
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
-
T
Y
P
-
A
L
L
G
L
E
Q
A
R
K
K
-
A
----
R
D
-----
L
I
D
D
A
R
Q
S
L
-
K
Q
L
A
E
---
Q
S
L
--
D
T
S
A
L
E
A
L
A
D
---
Y
I
-------------------------------------------------------
39
PsiBlast_CBE
52.14
34%
-68
- C1 -
1RQI
5
ISPA_ECOLI
B:
[45-295]
------------------------------------------------------------------------------
G
K
R
L
R
P
F
L
V
Y
-
A
T
G
H
M
F
G
V
S
------
T
-----
N
T
-----
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
--
P
A
M
D
D
D
DL
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
D
-
A
D
M
P
-
E
-----
V
S
D
R
--
D
-
R
I
S
------------
M
I
S
E
--
L
-----------
A
---
S
A
S
G
I
AG
M
C
G
G
Q
A
L
D
L
D
A
E
G
--
K
-------------
H
----------
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
-
I
R
A
A
V
R
L
G
A
L
S
A
G
D
K
G
-
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
-
T
Y
P
-
A
L
L
G
L
E
Q
A
R
K
K
-
A
----
R
D
-----
L
I
D
D
A
R
Q
S
L
-
K
Q
L
A
E
---
Q
S
L
--
D
T
S
A
L
E
A
L
A
D
---
Y
I
-------------------------------------------------------
40
PsiBlast_CBE
51.34
34%
-70
- C1 -
1RQI
6
ISPA_ECOLI
A:
[45-295]
------------------------------------------------------------------------------
G
K
R
L
R
P
F
L
V
Y
-
A
T
G
H
M
F
G
V
S
------
T
-----
N
T
-----
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
--
P
A
M
D
D
D
DL
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
D
-
A
D
M
P
-
E
-----
V
S
D
R
--
D
-
R
I
S
------------
M
I
S
E
--
L
-----------
A
---
S
A
S
G
I
AG
M
C
G
G
Q
A
L
D
L
D
A
E
G
--
K
-------------
H
----------
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
-
I
R
A
A
V
R
L
G
A
L
S
A
G
D
K
G
-
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
-
T
Y
P
-
A
L
L
G
L
E
Q
A
R
K
K
-
A
----
R
D
-----
L
I
D
D
A
R
Q
S
L
-
K
Q
L
A
E
---
Q
S
L
--
D
T
S
A
L
E
A
L
A
D
---
Y
I
-------------------------------------------------------
49
PsiBlast_CBE
41.93
33%
-58
- C1 -
4LFG
5
?
B:
[35-242]
-------------------------------------------------------------------------
N
A
--
G
G
K
R
I
R
P
I
L
F
L
-
E
V
I
E
A
L
Q
I
P
L-----
T
-----
E
S
-----
H
F
K
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
PA
M
D
N
D
D
Y
--
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
D
S
L
F
L
D
A
F
G
M
L
A
E
-
T
D
F
P
T
D
-----
V
T
V
D
--
L
V
R
--------------
S
L
S
S
--
A
S
G---------
T
---
F
G
-----
M
V
G
G
Q
M
L
D
M
A
A
E
G
--
K
------------
K
-----------
L
N
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
-
L
A
Y
P
F
W
A
A
A
R
V
A
Q
-
L
D
-
E
-
N
L
L
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
-
T
Y
P
----------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
41.62
36%
-66
- C1 -
3KRC
1
?
A:
[43-264]
------------------------------------------------------------------------------
G
K
R
V
R
P
M
L
C
I
-
A
A
C
E
L
V
G
G
D
------
E
-----
S
T
-----
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
--
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
----------
H
-----
V
A
A
A
--
T
-
K
GAP
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
--
G
-----------
S
---
E
G
-----
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
------------
A
E
----------
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
-
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
-
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
-
T
Y
P
-
K
L
I
G
V
E
K
S
K
E
F
-
A
----
D
R
-----
L
--------------------------------------------------------------------------------------------
9
PsiBlast_PDB
41.61
36%
-63
- C1 -
3KRO
4
?
A:
[43-264]
------------------------------------------------------------------------------
G
K
R
V
R
P
M
L
C
I
-
A
A
C
E
L
V
G
G
D
------
E
-----
S
T
-----
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
--
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
----------
H
-----
V
A
A
A
--
T
-
K
GAP
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
--
G
-----------
S
---
E
G
-----
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
------------
A
E
----------
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
-
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
-
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
-
T
Y
P
-
K
L
I
G
V
E
K
S
K
E
F
-
A
----
D
R
-----
L
--------------------------------------------------------------------------------------------
22
PsiBlast_CBE
41.59
36%
-50
- C1 -
3OAC
4
?
D:
[43-264]
------------------------------------------------------------------------------
G
K
R
V
R
P
M
L
C
I
-
A
A
C
E
L
V
G
G
D
------
E
-----
S
T
-----
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
--
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
----------
H
-----
V
A
A
A
--
T
-
K
GAPPERIVRVLGEL
A
V
S
I
--
G
-----------
S
---
E
G
-----
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
------------
A
E
----------
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
-
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
-
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
-
T
Y
P
-
K
L
I
G
V
E
K
S
K
E
F
-
A
----
D
R
-----
L
--------------------------------------------------------------------------------------------
51
PsiBlast_CBE
41.55
33%
-59
- C1 -
4LFE
5
?
B:
[35-242]
-------------------------------------------------------------------------
N
A
--
G
G
K
R
I
R
P
I
L
F
L
-
E
V
I
E
A
L
Q
I
P
L
-----
T
-----
E
S
-----
H
F
K
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
PA
M
D
N
D
D
Y
--
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
D
S
L
F
L
D
A
F
G
M
L
A
E
-
T
D
F
P
T
D
-----
V
T
V
D
--
L
V
R
--------------
S
L
S
S
--
A
S
G---------
T
---
F
G
-----
M
V
G
G
Q
M
L
D
M
A
A
E
G
--
K
------------
K
-----------
L
N
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
-
L
A
Y
P
F
W
A
A
A
R
V
A
Q
-
L
D
-
E
-
N
L
L
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
-
T
Y
P
----------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
41.53
36%
-67
- C1 -
3KRF
4
?
A:
[43-264]
------------------------------------------------------------------------------
G
K
R
V
R
P
M
L
C
I
-
A
A
C
E
L
V
G
G
D
------
E
-----
S
T
-----
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
--
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
----------
H
-----
V
A
A
A
--
T
-
K
GAP
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
--
G
-----------
S
---
E
G
-----
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
------------
A
E
----------
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
-
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
-
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
-
T
Y
P
-
K
L
I
G
V
E
K
S
K
E
F
-
A
----
D
R
-----
L
--------------------------------------------------------------------------------------------
29
PsiBlast_CBE
41.39
37%
-57
- C1 -
4LLT
5
?
B:
[59-284]
-------------------------------------------------------------------------
T
S
--
G
G
K
R
L
R
G
F
L
V
L
-
E
T
A
R
L
H
D
I
A
------
A
-----
G
E
-----
A
I
W
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
PC
M
D
N
D
D
M
--
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
------
T
-
H
-----
P
G
A
S
--
A
-
S
--------------
A
E
V
R
--
A
D
L
A
L
S
L
A
R
A
S
G
A
---
Q
G
-----
M
V
L
G
Q
A
L
D
I
A
A
E
T
A-
R
------------
A
P
----------
L
S
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
-
I
G
W
S
A
Q
A
G
A
R
L
A
Q
-
A
D
-
T
-
A
---
A
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
------
A
T
F
V
S
L
L
G
L
D
A
-
A
----
R
A
-----
R
---
A
M
S
L
I
-
D
E
---------------------------------------------------------------------------------
31
PsiBlast_CBE
41.35
37%
-58
- C1 -
4LLS
6
?
B:
[59-284]
-------------------------------------------------------------------------
T
S
--
G
G
K
R
L
R
G
F
L
V
L
-
E
T
A
R
L
H
D
I
A
------
A
-----
G
E
-----
A
I
W
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
PC
M
D
N
D
D
M
--
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
------
T
-
H
-----
P
G
A
S
--
A
-
S
--------------
A
E
V
R
--
A
D
L
A
L
S
L
A
R
A
S
G
A
---
Q
G
-----
M
V
L
G
Q
A
L
D
I
A
A
E
T
A-
R
------------
A
P
----------
L
S
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
-
I
G
W
S
A
Q
A
G
A
R
L
A
Q
-
A
D
-
T
-
A
---
A
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
------
A
T
F
V
S
L
L
G
L
D
A
-
A
----
R
A
-----
R
---
A
M
S
L
I
-
D
E
---------------------------------------------------------------------------------
35
PsiBlast_CBE
41.33
33%
-67
- C1 -
3Q1O
3
?
B:
[53-256]
--------------------------------------------------------------------------
N
--
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
------
D
-----
Y
S
N
Q
Q
T
E
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
PC
M
D
N
A
A
L
--
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
N
A
L
L
E
S
-
H
-----
I
I
V
E
--
L
-
I
--------------
K
I
L
S
--
A
-----------
N
G
G
I
K
G
-----
M
I
L
G
Q
A
L
D
C
Y
F
E
N
---------------
T
P
----------
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
-
I
S
A
S
L
I
M
G
L
V
A
S
G
-
I
K
D
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
--------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
41.26
36%
-62
- C1 -
3OAB
4
?
A:
[43-264]
------------------------------------------------------------------------------
G
K
R
V
R
P
M
L
C
I
-
A
A
C
E
L
V
G
G
D
------
E
-----
S
T
-----
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
--
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
----------
H
-----
V
A
A
A
--
T
-
K
GAP
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
--
G
-----------
S
---
E
G
-----
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
------------
A
E
----------
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
-
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
-
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
-
T
Y
P
-
K
L
I
G
V
E
K
S
K
E
F
-
A
----
D
R
-----
L
--------------------------------------------------------------------------------------------
25
PsiBlast_CBE
41.11
36%
-51
- C1 -
3KRO
4
?
D:
[43-264]
------------------------------------------------------------------------------
G
K
R
V
R
P
M
L
C
I
-
A
A
C
E
L
V
G
G
D
------
E
-----
S
T
-----
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
--
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
----------
H
-----
V
A
A
A
--
T
-
K
GAPPERIVRVLGEL
A
V
S
I
--
G
-----------
S
---
E
G
-----
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
------------
A
E
----------
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
-
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
-
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
-
T
Y
P
-
K
L
I
G
V
E
K
S
K
E
F
-
A
----
D
R
-----
L
--------------------------------------------------------------------------------------------
50
PsiBlast_CBE
40.99
33%
-57
- C1 -
4LFG
5
?
A:
[35-242]
-------------------------------------------------------------------------
N
A
--
G
G
K
R
I
R
P
I
L
F
L
-
E
V
I
E
A
L
Q
I
P
L-----
T
-----
E
S
-----
H
F
K
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
PA
M
D
N
D
D
Y
--
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
D
S
L
F
L
D
A
F
G
M
L
A
E
-
T
D
F
P
T
D
-----
V
T
V
D
--
L
V
R
--------------
S
L
S
S
--
A
S
G---------
T
---
F
G
-----
M
V
G
G
Q
M
L
D
M
A
A
E
G
--
K
------------
K
-----------
L
N
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
-
L
A
Y
P
F
W
A
A
A
R
V
A
Q
-
L
D
-
E
-
N
L
L
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
-
T
Y
P
----------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
40.89
37%
-58
- C1 -
4LLT
5
?
A:
[59-284]
-------------------------------------------------------------------------
T
S
--
G
G
K
R
L
R
G
F
L
V
L
-
E
T
A
R
L
H
D
I
A
------
A
-----
G
E
-----
A
I
W
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
PC
M
D
N
D
D
M
--
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
------
T
-
H
-----
P
G
A
S
--
A
-
S
--------------
A
E
V
R
--
A
D
L
A
L
S
L
A
R
A
S
G
A
---
Q
G
-----
M
V
L
G
Q
A
L
D
I
A
A
E
T
A
-
R
------------
A
P
----------
L
S
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
-
I
G
W
S
A
Q
A
G
A
R
L
A
Q
-
A
D
-
T
-
A
---
A
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
------
A
T
F
V
S
L
L
G
L
D
A
-
A
----
R
A
-----
R
---
A
M
S
L
I
-
D
E
---------------------------------------------------------------------------------
10
PsiBlast_PDB
40.88
36%
-62
- C1 -
3KRP
3
?
A:
[43-264]
------------------------------------------------------------------------------
G
K
R
V
R
P
M
L
C
I
-
A
A
C
E
L
V
G
G
D
------
E
-----
S
T
-----
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
--
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
----------
H
-----
V
A
A
A
--
T
-
K
GAP
P
E
R
I
V
R
V
L
G
E
L
A
V
S
I
--
G
-----------
S
---
E
G
-----
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
------------
A
E
----------
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
-
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
-
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
-
T
Y
P
-
K
L
I
G
V
E
K
S
K
E
F
-
A
----
D
R
-----
L
--------------------------------------------------------------------------------------------
23
PsiBlast_CBE
40.70
36%
-47
- C1 -
3OAB
4
?
D:
[43-264]
------------------------------------------------------------------------------
G
K
R
V
R
P
M
L
C
I
-
A
A
C
E
L
V
G
G
D
------
E
-----
S
T
-----
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
--
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
----------
H
-----
V
A
A
A
--
T
-
K
GAPPERIVRVLGEL
A
V
S
I
--
G
-----------
S
---
E
G
-----
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
------------
A
E
----------
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
-
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
-
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
-
T
Y
P
-
K
L
I
G
V
E
K
S
K
E
F
-
A
----
D
R
-----
L
--------------------------------------------------------------------------------------------
36
PsiBlast_CBE
40.59
33%
-67
- C1 -
3Q1O
4
?
A:
[53-256]
--------------------------------------------------------------------------
N
--
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
------
D
-----
Y
S
N
Q
Q
T
E
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
PC
M
D
N
A
A
L
--
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
N
A
L
L
E
S
-
H
-----
I
I
V
E
--
L
-
I
--------------
K
I
L
S
--
A
-----------
N
G
G
I
K
G
-----
M
I
L
G
Q
A
L
D
C
Y
F
E
N
---------------
T
P
----------
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
-
I
S
A
S
L
I
M
G
L
V
A
S
G
-
I
K
D
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
--------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
40.19
33%
-66
- C1 -
3Q1O
3
?
D:
[53-256]
--------------------------------------------------------------------------
N
--
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
------
D
-----
Y
S
NQQTE
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
PC
M
D
N
A
A
L
--
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
N
A
L
L
E
S
-
H
-----
I
I
V
E
--
L
-
I
--------------
K
I
L
S
--
A
-----------
N
GGI
K
G
-----
M
I
L
G
Q
A
L
D
C
Y
F
E
N
---------------
T
P
----------
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
-
I
S
A
S
L
I
M
G
L
V
A
S
G
-
I
K
D
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
--------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
39.96
37%
-57
- C1 -
4LLS
6
?
A:
[59-284]
-------------------------------------------------------------------------
T
S
--
G
G
K
R
L
R
G
F
L
V
L
-
E
T
A
R
L
H
D
I
A
------
A
-----
G
E
-----
A
I
W
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
PC
M
D
N
D
D
M
--
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
------
T
-
H
-----
P
G
A
S
--
A
-
S
--------------
A
E
V
R
--
A
D
L
A
L
S
L
A
R
A
S
G
A
---
Q
G
-----
M
V
L
G
Q
A
L
D
I
A
A
E
T
A
-
R
------------
A
P
----------
L
S
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
-
I
G
W
S
A
Q
A
G
A
R
L
A
Q
-
A
D
-
T
-
A
---
A
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
------
A
T
F
V
S
L
L
G
L
D
A
-
A
----
R
A
-----
R
---
A
M
S
L
I
-
D
E
---------------------------------------------------------------------------------
26
PsiBlast_CBE
39.89
36%
-50
- C1 -
3KRF
4
?
D:
[43-264]
------------------------------------------------------------------------------
G
K
R
V
R
P
M
L
C
I
-
A
A
C
E
L
V
G
G
D
------
E
-----
S
T
-----
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
--
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
----------
H
-----
V
A
A
A
--
T
-
K
GAPPERIVRVLGEL
A
V
S
I
--
G
-----------
S
---
E
G
-----
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
------------
A
E
----------
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
-
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
-
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
-
T
Y
P
-
K
L
I
G
V
E
K
S
K
E
F
-
A
----
D
R
-----
L
--------------------------------------------------------------------------------------------
34
PsiBlast_CBE
39.76
33%
-65
- C1 -
3Q1O
5
?
C:
[53-256]
--------------------------------------------------------------------------
N
--
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
------
D
-----
Y
S
NQQTE
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
PC
M
D
N
A
A
L
--
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
N
A
L
L
E
S
-
H
-----
I
I
V
E
--
L
-
I
--------------
K
I
L
S
--
A
-----------
N
GGI
K
G
-----
M
I
L
G
Q
A
L
D
C
Y
F
E
N
---------------
T
P
----------
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
-
I
S
A
S
L
I
M
G
L
V
A
S
G
-
I
K
D
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
--------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
39.49
36%
-66
- C1 -
3KRP
3
?
D:
[43-264]
------------------------------------------------------------------------------
G
K
R
V
R
P
M
L
C
I
-
A
A
C
E
L
V
G
G
D
------
E
-----
S
T
-----
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
--
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
----------
H
-----
V
A
A
A
--
T
-
K
GAPPERIVRVLGEL
A
V
S
I
--
G
-----------
S
---
E
G
-----
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
------------
A
E
----------
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
-
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
-
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
------------
T
Y
P
-
K
L
I
G
V
E
K
S
K
E
F
-
A
----
D
R
-----
L
--------------------------------------------------------------------------------------------