@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3709c: (2016-05-22 )
MALVVQKYGGSSVADAERIRRVAERIVATKKQGNDVVVVVSAMGDTTDDLLDLAQQVCPAPPPRELDMLLTAGERISNALVAMAIESLGAHARSFTGSQAGVITTGTHGNAKIIDVTPGRLQTALEEGRVVLVAGFQGVSQDTKDVTTLGRGGSDTTAVAMAAALGADVCEIYTDVDGIFSADPRIVRNARKLDTVTFEEMLEMAACGAKVLMLRCVEYARRHNIPVHVRSSYSDRPGTVVVGSIKDVPMEDPILTGVAHDRSEAKVTIVGLPDIPGYAAKVFRAVADADVNIDMVLQNVSKVEDGKTDITFTCSRDVGPAAVEKLDSLRNEIGFSQLLYDDHIGKVSLIGAGMRSHPGVTATFCEALAAVGVNIELISTSEIRISVLCRDTELDKAVVALHEAFGLGGDEEATVYAGTGR
Atome Classification :
(22 SA)
-.........10........20........30........40...-------....-------.----------------------------------------------50.......---------------------------------------------------------.-----------------------------------------------60---------------------------------------------------------.....-----...70........80----.........90........100.......110.--.-----..-.-----------------------..120.-......130---.........140.......150.......160.......170.......180........190.......200....-...210.......220.......230...-..-.-..240......-.----250....---------...260.......270.--....--....280.....-..290.....-..300......-.310..-.-..-------.---.320.---.---..--...330----.-----.-.-----.....340..-..----...350.-......360.......370....-.-..--380.........390.......400.......410.......420
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-
M
A
L
V
V
QKYGGSSVA
D
A
E
R
I
R
R
V
A
E
R
I
V
A
TKKQGN
D
V
V
V
V
V
SAMG-------D
T
T
D
-------
D
----------------------------------------------
L
L
D
L
A
Q
Q
VC---------------------------------------------------------P-----------------------------------------------AP---------------------------------------------------------
P
P
R
E
L
-----
D
M
L
L
T
A
G
E
R
I
S
N
A
L
-----
V
A
M
A
I
E
S
L
G
A
H
A
RSFTGSQ
A
G
V
I
T
TGTHG
N
A
K
I
--
I
-----
D
V-T-----------------------
P
G
R
L
Q
T
-
A
L
EEG
R
V
-----
V
L
V
AGFQGVSQDT
K
D
V
T
TLGRGGS
D
T
T
A
V
A
M
A
A
A
L
G
A
D
V
C
E
I
Y
TDV
D
G
IFS-A
D
P
R
I
V
R
NARKLDTV
T
F
E
E
M
L
E
M
A
A-C
G
A
K
V
L
M
L
R
C
V
E
Y
A
R
RHNI
P
V
H
V
R-SSYS-DR-P-
G
T
V
V
V
GSIKDV-P----MEDPILT---------GVAHDRSE
A
K
V
T
I
V
--G--LPDI--P
G
Y
A
A
K
V
F
R
A
V
A-DAD
V
N
I
D
M
V
L
-
Q
N
V
S
K
VEDGKT-
D
I
T
F
T
C-S-RD-------V---
G
P
A
A
V
---
E
---
K
L
--
D
S
L
R
N
-----E-----I-G-----
F
S
Q
L
L
YDDHI-G
K
----
V
S
L
I
GAG-MRSHPG
V
T
A
T
F
C
E
A
L
A
AVG
V
N
I
E
-
L
-
I
S--T--S
E
I
R
I
S
V
L
C
RDT
E
L
D
K
A
V
V
A
L
H
E
A
FGLGGDE
E
A
T
V
Y
AGTGR
23
PsiBlast_CBE
97.88
71%
-130
- C1 -
3AAW
4
AK_CORGL
C:
[1-409]
-
M
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
-------
D
T
T
D
-------
E
----------------------------------------------
L
L
E
L
A
A
A
V
N
---------------------------------------------------------
P
-----------------------------------------------
V
P
---------------------------------------------------------
P
A
R
E
M
-----
D
M
L
L
T
A
G
E
R
I
S
N
A
L
-----
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
G
S
Q
----------------------
D
V
-
T
-----------------------
P
G
R
V
R
E
-
A
L
D
E
G
K
I
-----
C
I
V
A
G
F
Q
G
V
N
K
--
R
D
V
T
T
L
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
-
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
-
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
-
S
S
Y
S
-
N
D
-
P
-
G
T
L
I
A
G
S
M
E
D
I
-
P
----
V
E
E
A
V
L
T
---------
G
V
A
T
D
K
S
E
A
K
V
T
V
L
--
G
--
I
S
D
K
--
P
G
E
A
A
K
V
F
R
A
L
A
-
D
A
E
I
N
I
D
M
V
L
-
Q
N
V
S
S
V
E
D
G
T
T
-
D
I
T
F
T
C
-
P
-
R
S
-------
D
---
G
R
R
A
M
---
E
---
I
L
--
K
K
L
Q
V
-----
Q
-----
G
-
N
-----
W
T
N
V
L
Y
D
D
Q
V
-
G
K
----
V
S
L
V
G
A
G
-
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
-
L
-
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
------------
1
PsiBlast_PDB
97.35
71%
-130
* C1 *
3AAW
3
AK_CORGL
A:
[2-409]
--
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
-------
D
T
T
D
-------
E
----------------------------------------------
L
L
E
L
A
A
A
V
N
---------------------------------------------------------
P
-----------------------------------------------
V
P
---------------------------------------------------------
P
A
R
E
M
-----
D
M
L
L
T
A
G
E
R
I
S
N
A
L
-----
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
--------------------------
V
-
T
-----------------------
P
G
R
V
R
E
-
A
L
D
E
G
K
I
-----
C
I
V
A
G
F
--
V
N
K
E
T
R
D
V
T
T
L
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
-
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
-
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
-
S
S
Y
S
-
N
D
-
P
-
G
T
L
I
A
G
S
M
E
D
I
-
P
----
V
E
E
A
V
L
T
---------
G
V
A
T
D
K
S
E
A
K
V
T
V
L
--
G
--
I
S
D
K
--
P
G
E
A
A
K
V
F
R
A
L
A
-
D
A
E
I
N
I
D
M
V
L
-
Q
N
V
S
S
V
E
D
G
T
T
-
D
I
T
F
T
C
-
P
-
R
S
-------
D
---
G
R
R
A
M
---
E
---
I
L
--
K
K
L
Q
V
-----
Q
-----
G
-
N
-----
W
T
N
V
L
Y
D
D
Q
V
-
G
K
----
V
S
L
V
G
A
G
-
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
-
L
-
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
------------
21
PsiBlast_CBE
95.44
71%
-124
- C1 -
3AB2
5
AK_CORGL
O:
[2-411]
--
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
-------
D
T
T
D
-------
E
----------------------------------------------
L
L
E
L
A
A
A
V
N
---------------------------------------------------------
P
-----------------------------------------------
V
P
---------------------------------------------------------
P
A
R
E
M
-----
D
M
L
L
T
A
G
E
R
I
S
N
A
L
-----
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
G
S
Q
A
G
V
L
T
--------------------
T
-----------------------
P
G
R
V
R
E
-
A
L
D
E
G
K
I
-----
C
I
V
A
G
F
Q
------------
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
-
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
-
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
-
S
S
Y
S
-
N
D
-
P
-
G
T
L
I
A
G
S
M
E
D
I
-
P
----
V
E
E
A
V
L
T
---------
G
V
A
T
D
K
S
E
A
K
V
T
V
L
--
G
--
I
S
D
K
--
P
G
E
A
A
K
V
F
R
A
L
A
-
D
A
E
I
N
I
D
M
V
L
-
Q
N
V
S
S
V
E
D
G
T
T
-
D
I
T
F
T
C
-
P
-
R
S
-------
D
---
G
R
R
A
M
---
E
---
I
L
--
K
K
L
Q
V
-----
Q
-----
G
-
N
-----
W
T
N
V
L
Y
D
D
Q
V
-
G
K
----
V
S
L
V
G
A
G
-
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
-
L
-
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
E
D
----------
22
PsiBlast_CBE
95.07
71%
-128
- C1 -
3AB2
2
AK_CORGL
E:
[2-408]
--
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
-------
D
T
T
D
-------
E
----------------------------------------------
L
L
E
L
A
A
A
V
N
---------------------------------------------------------
P
-----------------------------------------------
V
P
---------------------------------------------------------
P
A
R
E
M
-----
D
M
L
L
T
A
G
E
R
I
S
N
A
L
-----
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
G
S
Q
A
G
V
L
T
------------------
V
-
T
-----------------------
P
G
R
V
R
E
-
A
L
D
E
G
K
I
-----
C
I
V
A
G
F
Q
-------------
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
-
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
-
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
-
S
S
Y
S
-
N
D
-
P
-
G
T
L
I
A
G
S
M
E
D
I
-
P
----
V
E
E
A
V
L
T
---------
G
V
A
T
D
K
S
E
A
K
V
T
V
L
--
G
--
I
S
D
K
--
P
G
E
A
A
K
V
F
R
A
L
A
-
D
A
E
I
N
I
D
M
V
L
-
Q
N
V
S
S
V
E
D
G
T
T
-
D
I
T
F
T
C
-
P
-
R
S
-------
D
---
G
R
R
A
M
---
E
---
I
L
--
K
K
L
Q
V
-----
Q
-----
G
-
N
-----
W
T
N
V
L
Y
D
D
Q
V
-
G
K
----
V
S
L
V
G
A
G
-
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
-
L
-
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
-------------
30
PsiBlast_CBE
94.96
71%
-133
- C1 -
3AB4
3
?
C:
[2-409]
--
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
-------
D
T
T
D
-------
E
----------------------------------------------
L
L
E
L
A
A
A
V
N
---------------------------------------------------------
P
-----------------------------------------------
V
P
---------------------------------------------------------
P
A
R
E
M
-----
D
M
L
L
T
A
G
E
R
I
S
N
A
L
-----
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
----------------------------
T
-----------------------
P
G
R
V
R
E
-
A
L
D
E
G
K
I
-----
C
I
V
A
-----------------
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
-
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
-
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
-
S
S
Y
S
-
N
D
-
P
-
G
T
L
I
A
G
S
M
E
D
I
-
P
----
V
E
E
A
V
L
T
---------
G
V
A
T
D
K
S
E
A
K
V
T
V
L
--
G
--
I
S
D
K
--
P
G
E
A
A
K
V
F
R
A
L
A
-
D
A
E
I
N
I
D
M
V
L
-
Q
N
V
----
D
G
T
T
-
D
I
T
F
T
C
-
P
-
R
S
-------
D
---
G
R
R
A
M
---
E
---
I
L
--
K
K
L
Q
V
-----
Q
-----
G
-
N
-----
W
T
N
V
L
Y
D
D
Q
V
-
G
K
----
V
S
L
V
G
A
G
-
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
-
L
-
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
------------
29
PsiBlast_CBE
93.80
71%
-132
- C1 -
3AB4
3
?
E:
[2-409]
--
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
-------
D
T
T
D
-------
E
----------------------------------------------
L
L
E
L
A
A
A
V
N
---------------------------------------------------------
P
-----------------------------------------------
V
P
---------------------------------------------------------
P
A
R
E
M
-----
D
M
L
L
T
A
G
E
R
I
S
N
A
L
-----
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
G
---------------------------
T
-----------------------
P
G
R
V
R
E
-
A
L
D
E
G
K
I
-----
C
I
V
A
G
F
------------
L
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
-
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
-
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
-
S
S
Y
S
-
N
D
-
P
-
G
T
L
I
A
G
S
M
E
D
I
-
P
----
V
E
E
A
V
L
T
---------
G
V
A
T
D
K
S
E
A
K
V
T
V
L
--
G
--
I
S
D
K
--
P
G
E
A
A
K
V
F
R
A
L
A
-
D
A
E
I
N
I
D
M
V
L
-
Q
N
-------
T
T
-
D
I
T
F
T
C
-
P
-
R
S
-------
D
---
G
R
R
A
M
---
E
---
I
L
--
K
K
L
-------
Q
-----
G
-
N
-----
W
T
N
V
L
Y
D
D
Q
V
-
G
K
----
V
S
L
V
G
A
G
-
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
-
L
-
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
------------
24
PsiBlast_CBE
93.02
71%
-135
- C1 -
3AB4
13
?
O:
[2-407]
--
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
-------
D
T
T
D
-------
E
----------------------------------------------
L
L
E
L
A
A
A
V
N
---------------------------------------------------------
P
-----------------------------------------------
V
P
---------------------------------------------------------
P
A
R
E
M
-----
D
M
L
L
T
A
G
E
R
I
S
N
A
L
-----
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
-------------------------
D
V
-
T
-----------------------
P
G
R
V
R
E
-
A
L
D
E
G
K
I
-----
C
I
V
A
----------------
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
-
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
-
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
-
S
S
Y
S
-
N
D
-
P
-
G
T
L
I
A
G
S
M
E
D
I
-
P
----
V
E
E
A
V
L
T
---------
G
V
A
T
D
K
S
E
A
K
V
T
V
L
--
G
--
I
S
D
K
--
P
G
E
A
A
K
V
F
R
A
L
A
-
D
A
E
I
N
I
D
M
V
L
-
Q
N
-----
D
G
T
T
-
D
I
T
F
T
C
-
P
-
R
S
-------
D
---
G
R
R
A
M
---
E
---
I
L
--
K
K
--------
Q
-----
G
-
N
-----
W
T
N
V
L
Y
D
D
Q
V
-
G
K
----
V
S
L
V
G
A
G
-
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
-
L
-
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
--------------
28
PsiBlast_CBE
89.37
71%
-136
- C1 -
3AB4
1
?
G:
[2-407]
--
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
-------
D
T
T
D
-------
E
----------------------------------------------
L
L
E
L
A
A
A
V
N
---------------------------------------------------------
P
-----------------------------------------------
V
P
---------------------------------------------------------
P
A
R
E
M
-----
D
M
L
L
T
A
G
E
R
I
S
N
A
L
-----
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
------------------------------------------------------
R
V
R
E
-
A
L
D
E
G
K
I
-----
C
I
V
A
-----------------
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
-
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
-
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
-
S
S
Y
S
-
N
D
-
P
-
G
T
L
I
A
G
S
M
E
D
I
-
P
----
V
--
A
V
L
T
---------
G
V
A
T
D
K
S
E
A
K
V
T
V
L
--
G
--
I
S
D
K
--
P
G
E
A
A
K
V
F
R
A
L
A
-
D
A
E
I
N
I
D
M
V
L
-
Q
N
V
F
-----
T
T
-
D
I
T
F
T
C
-
P
-
R
S
-------
D
---
G
R
R
A
M
---
E
---
I
L
--
K
K
L
Q
V
-----
Q
-------------
W
T
N
V
L
Y
D
D
Q
V
-
G
K
----
V
S
L
V
G
A
G
-
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
-
L
-
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
--------------
4
PsiBlast_PDB
81.64
46%
-119
- C2 -
3L76
5
?
A:
[2-421]
--
A
L
I
V
Q
K
F
G
G
T
S
V
G
T
V
E
R
I
Q
A
V
A
Q
R
I
K
R
T
V
Q
G
G
N
S
L
V
V
V
V
S
A
M
G
-------
K
S
T
D
-------
V
----------------------------------------------
L
V
D
L
A
Q
Q
I
S
---------------------------------------------------------
P
-----------------------------------------------
N
P
---------------------------------------------------------
C
R
R
E
M
-----
D
M
L
L
S
T
G
E
Q
V
S
I
A
L
-----
L
S
L
A
L
Q
E
I
D
Q
P
A
I
S
L
T
G
A
Q
V
G
I
V
T
E
-------
I
--
L
-----
E
I
-
R
-----------------------
P
D
R
L
E
H
-
H
L
R
E
G
K
V
-----
V
V
V
A
G
F
Q
G
I
---
H
L
E
I
T
T
L
G
R
G
G
S
D
T
S
A
V
A
L
A
A
A
L
K
A
D
F
C
E
I
Y
T
D
V
P
G
I
L
T
-
T
D
P
R
L
V
P
E
A
Q
L
M
A
E
I
T
C
D
E
M
L
E
L
A
S
-
L
G
A
K
V
L
H
P
R
A
V
E
I
A
R
N
Y
G
I
P
L
V
V
R
-
S
S
W
S
-
D
E
-
P
-
G
T
K
V
V
A
P
-----
P
----
V
Q
N
R
S
L
V
GLEIAKAVD
G
V
E
Y
D
A
D
Q
A
K
V
A
L
L
--
R
--
V
P
D
R
--
P
G
V
A
S
K
L
F
R
D
I
A
-
Q
Q
Q
V
D
I
D
L
I
I
-
Q
S
---
I
H
D
G
N
S
N
D
I
A
F
T
V
-
V
-
K
D
L
L
N
T
A
E
A
V
---
T
S
A
I
A
---
P
---
A
L
--
R
S
Y
P
E
-----
A
-----
D
-
Q
-----
E
A
E
I
I
V
E
K
G
I
-
A
K
----
I
A
I
A
G
A
G
-
M
I
G
R
P
G
I
A
A
K
M
F
K
T
L
A
D
V
G
V
N
I
E
-
M
-
I
S
--
T
--
S
E
V
K
V
S
C
V
I
D
Q
R
D
A
D
R
A
I
A
A
L
S
N
A
F
G
V
--------------
88
HHSearch
80.54
48%
-110
- C2 -
3L76
5
?
A:
[2-420]
--
A
L
I
V
Q
K
F
G
G
T
S
V
G
T
V
E
R
I
Q
A
V
A
Q
R
I
K
R
T
V
Q
G
G
N
S
L
V
V
V
V
S
A
M
G
-------
K
S
T
D
-------
V
----------------------------------------------
L
V
D
L
A
Q
Q
I
S
---------------------------------------------------------
P
-----------------------------------------------
N
P
---------------------------------------------------------
C
R
R
E
M
-----
D
M
L
L
S
T
G
E
Q
V
S
I
A
L
-----
L
S
L
A
L
Q
E
I
D
Q
P
A
I
S
L
T
G
A
Q
V
G
I
V
T
E
-------
I
--
L
-----
E
I
-
R
-----------------------
P
D
R
L
E
H
-
H
L
R
E
G
K
V
-----
V
V
V
A
G
F
Q
G
I
---
H
L
E
I
T
T
L
G
R
G
G
S
D
T
S
A
V
A
L
A
A
A
L
K
A
D
F
C
E
I
Y
T
D
V
P
G
I
L
T
-
T
D
P
R
L
V
P
E
A
Q
L
M
A
E
I
T
C
D
E
M
L
E
L
A
S
-
L
G
A
K
V
L
H
P
R
A
V
E
I
A
R
N
Y
G
I
P
L
V
V
R
-
S
S
W
S
-
D
E
-
P
-
G
T
K
V
V
A
P
P
V
Q
N
R
S
LVGL
E
I
A
K
A
V
D
---------
G
V
E
Y
D
A
D
Q
A
K
V
A
L
L
--
R
--
V
P
D
R
--
P
G
V
A
S
K
L
F
R
D
I
A
-
Q
Q
Q
V
D
I
D
L
I
I
-
Q
S
I
H
D
--
G
N
S
N
-
D
I
A
F
T
V
-
V
-
K
D
-------
L
---
L
N
T
A
E
---
A
V
T
S
A
I
--
A
P
A
L
R
SYPE-
A
-----
D
-
Q
-----
E
A
E
I
I
V
E
K
G
I
-
A
K
----
I
A
I
A
G
A
G
-
M
I
G
R
P
G
I
A
A
K
M
F
K
T
L
A
D
V
G
V
N
I
E
-
M
-
I
S
--
T
--
S
E
V
K
V
S
C
V
I
D
Q
R
D
A
D
R
A
I
A
A
L
S
N
A
F
G
---------------
105
Fugue
79.22
34%
-113
- C2 -
3C1M
6
AK_METJA
A:
[2-470]
---
T
T
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
-------
E
V
T
N
-------
A
----------------------------------------------
L
V
E
I
S
Q
Q
A
L
---------------------------------------------------------
D
-----------------------------------------------
V
R
D
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
E
A
I
KS
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
I
G
V
A
Y
L
GEL
T
P
K
S
R
-----
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
-----
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
--
K
-----
R
L
E
V
-----------------------
K
E
R
L
L
P
-
L
L
K
E
G
I
I
-----
P
V
V
T
G
F
I
G
T
T
E
E
-
G
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
-
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
-
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
-
N
T
F
E
P
E
S
-
E
-
G
T
L
I
T
---
N
D
M
-
E
----
M
S
D
S
I
V
K
---------
A
I
S
T
I
K
N
V
A
L
I
N
I
F
--
G
AG
M
V
G
V
--
S
G
T
A
A
R
I
F
K
A
L
G
-
E
E
E
V
N
V
I
L
I
S
-
Q
G
-----
S
S
E
T
-
N
I
S
L
V
V
-
S
-
E
E
-------
D
---
V
D
K
A
L
---
K
---
A
L
--
K
R
E
F
G
DSFLN
N
-----
N
-
L
-----
I
R
D
V
S
V
D
K
D
V
-
C
V
----
I
S
V
V
G
A
G
-
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
-
M
-
I
A
--
Q
GS
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
-------------
84
HHSearch
78.96
35%
-116
* C2 *
3C1M
6
AK_METJA
A:
[2-470]
---
T
T
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
-------
E
V
T
N
-------
A
----------------------------------------------
L
V
E
I
S
Q
Q
A
L
DVRD
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
E
A
I
KS
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
I
G
V
A
Y
L
G
-----------------------------------------------
E
L
---------------------------------------------------------
T
P
K
S
R
-----
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
-----
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
--
K
-----
R
L
-
E
V----------------------
K
E
R
L
L
P
-
L
L
K
E
G
I
I
-----
P
V
V
T
G
F
I
G
T
T
E
-
E
G
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
-
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
-
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
-
N
T
F
E
-
P
E
-
S
E
G
T
L
I
T
N
D
M
E
--------
M
S
D
S
I
V
K
---------
A
I
S
T
I
K
N
V
A
L
I
N
I
F
--
G
--
A
G
M
V
G
V
S
G
T
A
A
R
I
F
K
A
L
G
-
E
E
E
V
N
V
I
L
I
S
-
Q
G
S
S
E
-----
T
-
N
I
S
L
V
V
-
S
-
E
E
-------
D
---
V
D
K
A
L
---
K
---
A
L
--
K
R
E
F
G
-----
D
SFLNN
N
-
L
-----
I
R
D
V
S
V
D
K
D
V
-
C
V
----
I
S
V
V
G
A
G
-
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
-
M
-
I
A
Q
G
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
-------------
104
Fugue
75.29
32%
-104
- C2 -
2CDQ
5
AK1_ARATH
A:
[25-494]
K
G
I
T
C
V
M
K
F
G
G
S
S
V
A
S
A
E
R
M
K
E
V
A
D
L
I
L
T
F
P
E
--
E
S
P
V
I
V
L
S
A
M
G
-------
K
T
T
N
-------
N
----------------------------------------------
L
L
L
A
G
E
K
A
V
---------------------------------------------------------
S
-----------------------------------------------
C
G
VSNASEI
E
E
L
S
I
I
K
E
L
H
I
R
T
V
K
E
L
NIDP
S
V
I
L
T
Y
L
E
E
L
E
Q
L
L
K
G
I
A
M
M
KEL------
T
L
R
T
R
-----
D
Y
L
V
S
F
G
E
C
L
S
T
R
I
-----
F
A
A
Y
L
N
T
I
G
V
K
A
R
Q
Y
D
A
F
E
I
G
F
I
T
T
D
D
F
T
N
G
D
I
--
L
-----
E
A
-
T
-----------------------
Y
P
A
V
A
K
-
R
L
Y
D
D
W
M
H
DP
A
V
P
I
V
T
G
F
L
G
K
G
W
K
T
G
A
V
T
T
L
G
R
G
G
S
D
L
T
A
T
T
I
G
K
A
L
G
L
K
E
I
Q
V
W
K
D
V
D
G
V
L
T
-
C
D
P
T
I
Y
K
R
A
T
P
V
P
Y
L
T
F
D
E
A
A
E
L
A
Y
-
F
G
A
Q
V
L
H
P
Q
S
M
R
P
A
R
E
G
E
I
P
V
R
V
K
-
N
S
Y
N
P
K
A
-
P
-
G
T
I
I
T
---
K
T
R
-
D
----
M
T
K
S
I
L
T
---------
S
I
V
L
K
R
N
V
T
M
L
D
I
A
S
T
R
--
M
L
G
Q
--
V
G
F
L
A
K
V
F
S
I
F
E
-
E
L
G
I
S
V
D
V
V
A
-
T
S
-------
E
V
-
S
I
S
L
T
L
-
D
-
P
S
-------
K
LWS
R
E
L
I
Q
---
Q
---
E
L
--
D
H
V
V
E
-----
E
-----
L
-
E
K
----
I
A
V
V
N
L
L
K
G
R
-
A
I
----
I
S
L
I
G
-
N
-
V
Q
H
S
S
L
I
L
E
R
A
F
H
V
L
Y
T
K
G
V
N
V
Q
-
M
-
I
S
--
Q
G
A
S
K
V
N
I
S
F
I
V
N
E
A
E
A
E
G
C
V
Q
A
L
H
K
S
F
F
E
S
G
D
L
S
E
L
L
I
Q
----
85
HHSearch
73.79
32%
-104
- C2 -
2CDQ
5
AK1_ARATH
A:
[27-494]
--
I
T
C
V
M
K
F
G
G
S
S
V
A
S
A
E
R
M
K
E
V
A
D
L
I
L
T
F
P
E
--
E
S
P
V
I
V
L
S
A
M
G
-------
K
T
T
N
-------
N
----------------------------------------------
L
L
L
A
G
E
K
A
V
SCGVSNASEI
E
E
L
S
I
I
K
E
L
H
I
R
T
V
K
E
L
NIDP
S
V
I
L
T
Y
L
E
E
L
E
Q
L
L
K
G
I
A
M
M
------
K
-----------------------------------------------
E
L
---------------------------------------------------------
T
L
R
T
R
-----
D
Y
L
V
S
F
G
E
C
L
S
T
R
I
-----
F
A
A
Y
L
N
T
I
G
V
K
A
R
Q
Y
D
A
F
E
I
G
F
I
T
T
D
D
F
T
N
G
D
I
--
L
EA
T
Y
P
A
V
-
A
-----------------------
K
R
L
Y
D
D
-
W
M
H
D
P
A
V
-----
P
I
V
T
G
F
L
G
K
G
W
K
T
G
A
V
T
T
L
G
R
G
G
S
D
L
T
A
T
T
I
G
K
A
L
G
L
K
E
I
Q
V
W
K
D
V
D
G
V
L
T
-
C
D
P
T
I
Y
K
R
A
T
P
V
P
Y
L
T
F
D
E
A
A
E
L
A
Y
-
F
G
A
Q
V
L
H
P
Q
S
M
R
P
A
R
E
G
E
I
P
V
R
V
K
-
N
S
Y
N
-
P
K
-
A
P
G
T
I
I
T
K
T
R
D
--------
M
T
K
S
I
L
T
---------
S
I
V
L
K
R
N
V
T
M
L
D
I
A
--
S
--
T
R
M
L
GQ
V
G
F
L
A
K
V
F
S
I
F
E
-
E
L
G
I
S
V
D
V
V
A
-
T
S
E
V
--------
S
I
S
L
T
L
-
D
-
P
S
-------
K
---
L
W
S
R
E
LI
Q
Q
---
E
L
--
D
H
V
V
E
-----
E
-----
L
E
K
-----
I
A
V
V
N
L
L
K
G
R
-
A
I
----
I
S
L
I
G
N
--
V
Q
H
S
S
L
I
L
E
R
A
F
H
V
L
Y
T
K
G
V
N
V
Q
-
M
-
I
S
--
Q
G
A
S
K
V
N
I
S
F
I
V
N
E
A
E
A
E
G
C
V
Q
A
L
H
K
S
F
F
E
S
G
D
L
S
E
L
L
I
Q
----
86
HHSearch
71.57
31%
-102
- C2 -
2J0W
4
AK3_ECOLI
A:
[3-448]
--
E
I
V
V
S
K
F
G
G
T
S
V
A
D
F
D
A
M
N
R
S
A
D
I
V
L
S
D
---
A
N
V
R
L
V
V
L
S
A
S
A
-------
G
I
T
N
-------
L
----------------------------------------------
L
V
A
L
A
E
G
L
E
---------------------------------------------------------
P
G
E
R
F
E
K
L
D
A
I
R
N
I
Q
F
A
I
L
E
R
LRYP
N
V
I
R
E
E
I
E
R
L
L
E
N
I
T
V
L
A
E
A
A
A
L
A
T
---------------------------------------------------------
S
P
A
L
T
-----
D
E
L
V
S
H
G
E
L
M
S
T
L
L
-----
F
V
E
I
L
R
E
R
D
V
Q
A
Q
W
F
D
V
R
K
V
-
M
R
T
N
D
R
F
G
R
A
E
P
--
D
-----
I
A
-
A
L
A
E
L
A
------------------
A
L
Q
L
L
P
-
R
L
N
E
-
G
L
-----
V
I
T
Q
G
F
I
G
S
E
N
-
K
G
R
T
T
T
L
G
R
G
G
S
D
Y
T
A
A
L
L
A
E
A
L
H
A
S
R
V
D
I
W
T
D
V
P
G
I
Y
T
-
T
D
P
R
V
V
S
A
A
K
R
I
D
E
I
A
F
A
E
A
A
E
M
A
T
-
F
G
A
K
V
L
H
P
A
T
L
L
P
A
V
R
S
D
I
P
V
F
V
G
-
S
S
K
D
-
P
R
-
A
G
G
T
L
V
C
N
K
T
E
---------
N
P
P
L
F
R
---------
A
L
A
L
R
R
N
Q
T
L
L
T
L
H
--
S
--
L
N
M
L
HS
R
G
F
L
A
E
V
F
G
I
L
A
-
R
H
N
I
S
V
D
L
I
T
-
T
S
E
V
--------
S
V
A
L
T
L
-
D
-
T
T
-------
G
---
S
T
S
T
G
---
D
---
T
L
LT
Q
S
L
L
M
-----
E
L
----
S
-
A
-----
L
C
R
V
E
V
E
E
G
L
-
A
L
----
V
A
L
I
G
N
D
-
L
S
K
A
C
G
V
G
K
E
V
F
G
V
L
E
P
--
F
N
I
R
-
M
-
I
C
Y
G
A
--
S
S
H
N
L
C
F
L
V
P
G
E
D
A
E
Q
V
V
Q
K
L
H
S
N
L
F
---------------
11
PsiBlast_PDB
71.50
30%
-92
- C2 -
2CDQ
5
AK1_ARATH
A:
[30-487]
-----
V
M
K
F
G
G
S
S
V
A
S
A
E
R
M
K
E
V
A
D
L
I
L
T
F
P
E
E
S
P
--
V
I
V
L
S
A
M
G
-------
K
T
T
N
-------
N
L
L
L
A
G
E
K
A
V
SCGVSNASEI
E
E
L
S
I
I
K
E
L
H
I
R
T
V
K
E
L
NIDP
S
V
I
L
T
Y
L
E
E
L
E
Q
L
L
K
---------------------------------------------------------
G
-----------------------------------------------
I
A
---------------------------------------------------------
M
M
K
E
L
T
L
R
T
R
D
Y
L
V
S
F
G
E
C
L
S
T
R
I
-----
F
A
A
Y
L
N
T
I
G
V
K
A
R
Q
Y
D
A
F
E
I
G
F
I
T
T
D
D
F
T
N
G
D
I
--
L
-----
E
A
-
T
Y
P
A
V
-------------------
A
K
R
L
Y
D
D
W
M
H
D
P
A
V
-----
P
I
V
T
G
F
L
G
K
G
W
K
T
G
A
V
T
T
L
G
R
G
G
S
D
L
T
A
T
T
I
G
K
A
L
G
L
K
E
I
Q
V
W
K
D
V
D
G
V
L
T
-
C
D
P
T
I
Y
K
R
A
T
P
V
P
Y
L
T
F
D
E
A
A
E
L
A
Y
-
F
G
A
Q
V
L
H
P
Q
S
M
R
P
A
R
E
G
E
I
P
V
R
V
K
-
N
S
Y
N
-
P
K
A
P
-
G
T
I
I
T
---
K
T
R
-
D
----
M
T
K
S
I
L
T
---------
S
I
V
L
K
R
N
V
T
M
L
D
I
A
--
S
--
T
R
M
L
GQ
V
G
F
L
A
K
V
F
S
I
F
E
-
E
L
G
I
S
V
D
V
V
---
A
T
S
E
V
S
I
S
L
T
L
D
P
S
K
L
W
-
S
-
R
E
-------
L
---
I
Q
Q
E
L
---
D
---
H
V
--
V
E
E
L
E
-----
K
-----
I
-
A
-----
V
V
N
L
L
K
G
R
A
I
-------
I
S
L
I
G
N
V
-
Q
H
S
S
L
I
L
E
R
A
F
-
H
V
L
Y
T
K
G
V
N
V
Q
-
M
-
I
S
Q
G
A
--
S
K
V
N
I
S
F
I
V
N
E
A
E
A
E
G
C
V
Q
A
L
H
K
S
F
F
E
S
G
D
-----------
87
HHSearch
67.69
23%
-112
- C2 -
3TVI
3
?
A:
[4-438]
---
I
V
V
T
K
F
G
G
S
S
L
A
D
S
N
Q
F
K
K
V
K
G
I
I
D
S
D
---
A
N
R
K
Y
I
I
P
S
A
P
G
-------
K
R
T
N
KDYK
I
T
D
L
----------------------------------------------
L
Y
L
C
N
A
H
V
K
N
GIPF
D
D
V
F
K
L
I
S
Q
R
Y
T
E
I
V
-------------------------------------
S
E
L
NIDMD
I
A
Y
Y
L
E
K
V
K
K
N
-----------------------------
I
E
---------------------------------------------------------
N
G
A
S
S
-----
D
Y
A
A
S
R
G
E
Y
L
N
G
V
I
-----
L
A
K
Y
L
N
A
E
F
I
D
-----
A
A
E
V
-
I
F
F
D
K
---
C
F
D
E
--------
K
K
-
S
-----------------------
Y
E
K
I
K
E
-
K
V
L
S
C
N
K
-----
A
V
I
P
G
F
Y
G
S
S
F
-
N
G
D
V
K
T
F
S
R
G
G
S
D
V
T
G
S
I
I
S
A
G
V
N
A
D
L
Y
E
N
W
T
D
V
S
G
F
L
M
-
A
D
P
R
I
V
E
N
P
K
T
I
S
K
I
S
Y
K
E
L
R
E
L
S
Y
-
M
----
L
H
E
E
A
I
F
P
V
K
D
S
G
I
P
I
N
I
K
-
N
T
N
K
-
P
S
-
D
P
G
T
L
I
L
S
D
T
H
K
--
E
----
I
N
L
G
T
I
T
---------
G
I
A
G
K
K
N
F
T
V
I
A
I
E
--
K
--
A
L
L
N
SE
V
G
F
C
R
K
I
L
S
I
L
E
-
M
Y
G
V
S
F
E
H
M
P
-
S
G
V
D
--------
S
V
S
L
V
I
-
E
-
D
C
-------
K
---
L
D
G
K
C
---
D
---
K
I
I
-
E
E
I
K
K
-----
Q
-----
C
-
N
-----
P
D
S
I
E
I
H
P
N
M
-
A
L
----
V
A
T
V
G
T
G
-
M
A
K
T
K
G
I
A
N
K
I
F
T
A
L
S
K
E
N
V
N
I
R
-
M
-
I
D
Q
G
S
--
S
E
I
N
V
I
V
G
V
E
T
V
D
F
E
K
A
V
K
S
I
Y
N
A
F
N
---------------
107
Fugue
66.19
23%
-98
- C2 -
3TVI
3
?
A:
[4-438]
---
I
V
V
T
K
F
G
G
S
S
L
A
D
S
N
Q
F
K
K
V
K
G
I
I
---
D
S
D
A
N
R
K
Y
I
I
P
S
A
P
G
KRTNKDY
K
I
T
D
-------
L
----------------------------------------------
L
Y
L
C
N
A
H
V
K
---------------------------------------------------------
N
G----------------------------------------------
I
P
---------------------------------------------------------
F
D
D
V
F
-----
K
L
I
S
Q
R
Y
T
E
I
V
S
E
L
NIDMD
I
A
Y
Y
L
E
K
V
K
K
N
I
E
N
-
G
A
S
S
D
Y
A
A
S
R
G
E
Y
L
N
G
V
I
--
L
-----
A
K
-
Y
L
N
A
E
F
I
D
AAE
V
I
F
F
D
KCFD
E
K
K
S
Y
E
K
I
K
E
-
K
V
L
S
C
N
K
-----
A
V
I
P
G
F
Y
G
S
S
F
N
-
G
D
V
K
T
F
S
R
G
G
S
D
V
T
G
S
I
I
S
A
G
V
N
A
D
L
Y
E
N
W
T
D
V
S
G
-
F
L
M
A
D
P
R
I
V
E
N
P
K
T
I
S
K
I
S
Y
K
E
L
R
E
L
S
Y
M
L
H
E
E
A
I
-----
F
P
V
K
D
S
G
I
P
I
N
I
K
N
T
N
K
P
-
S
D
-
P
-
G
T
L
I
L
S
D
T
H
K
E
-
I
----
N
L
G
T
I
-
T
---------
G
I
A
G
K
K
N
F
T
V
I
A
I
E
--
K
AL
L
N
S
E
--
V
G
F
C
R
K
I
L
S
I
L
E
M
Y
---
G
V
S
F
E
H
M
P
S
------
G
V
D
-
S
V
S
L
V
I
E
D
-
C
K
-------
L
---
D
G
K
C
D
---
K
---
I
I
--
E
E
I
K
K
-----
Q
-----
C
-
N
-----
P
D
S
I
E
I
H
P
-
N
M
A
L
----
V
A
T
V
G
T
G
M
A
K
T
K
-
G
I
A
N
K
I
F
T
A
L
S
K
E
N
V
N
I
R
M
I
D
Q
G
--
S
--
S
E
I
N
V
I
V
G
V
E
T
V
D
F
E
K
A
V
K
S
I
Y
N
A
F
N
---------------
7
PsiBlast_PDB
65.97
33%
-114
- C1 -
2HMF
3
AK_METJA
A:
[118-466]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
S
R
-----
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
-----
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
KR
L
-----
E
V
-
K
-----------------------
E
-
R
L
L
P
-
L
L
K
E
G
I
I
-----
P
V
V
T
G
F
I
G
T
T
E
E
G
Y
-
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
-
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
-
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
-
N
T
F
E
P
E
S
-
E
-
G
T
L
I
T
---
N
D
M
-
E
----
M
S
D
S
I
V
K
---------
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
A
G
--
M
V
G
V
--
S
G
T
A
A
R
I
F
K
A
L
G
-
E
E
E
V
N
V
I
L
I
S
-
Q
G
S
S
-----
E
T
-
N
I
S
L
V
V
-
S
E
E
D
-------
V
---
D
K
A
----------
L
--
K
A
L
K
R
-----
E
-----
F
-
G
DFL--
N
N
N
L
I
R
D
V
S
V
-
D
K
D
V
C
V
I
S
V
V
G
A
G
-
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
-
M
-
I
A
Q
G
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
----------------
48
PsiBlast_CBE
65.87
33%
-115
- C1 -
2HMF
3
AK_METJA
B:
[118-466]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
S
R
-----
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
-----
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
KR
L
-----
E
V
-
K
-----------------------
E
-
R
L
L
P
-
L
L
K
E
G
I
I
-----
P
V
V
T
G
F
I
G
T
T
E
E
G
Y
-
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
-
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
-
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
-
N
T
F
E
P
E
S
-
E
-
G
T
L
I
T
---
N
D
M
-
E
----
M
S
D
S
I
V
K
---------
A
I
S
T
I
K
N
V
A
L
I
N
I
F
GA
G
--
M
V
G
V
--
S
G
T
A
A
R
I
F
K
A
L
G
-
E
E
E
V
N
V
I
L
I
S
-
Q
G
S
S
-----
E
T
-
N
I
S
L
V
V
-
S
E
E
D
-------
V
---
D
K
A
----------
L
--
K
A
L
K
R
-----
E
-----
F
-
G
DFL--
N
N
N
L
I
R
D
V
S
V
-
D
K
DVCV
I
S
V
V
G
A
G
-
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
-
M
-
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
----------------
9
PsiBlast_PDB
63.51
33%
-110
- C1 -
3C20
3
AK_METJA
A:
[119-467]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
S
R
-----
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
-----
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
KR
L
-----
E
V
-
K
-----------------------
E
-
R
L
L
P
-
L
L
K
E
G
I
I
-----
P
V
V
T
G
F
I
G
T
T
E
E
G
Y
-
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
-
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
-
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
-
N
T
F
E
P
E
S
-
E
-
G
T
L
I
T
---
N
D
M
-
E
----
M
S
D
S
I
V
K
---------
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
A
G
--
M
V
G
V
--
S
G
T
A
A
R
I
F
K
A
L
G
-
E
E
E
V
N
V
I
L
I
S
-
Q
G
S
S
-----
E
T
-
N
I
S
L
V
V
-
S
E
E
D
-------
V
---
D
K
A
----------
L
--
K
A
L
K
R
-----
E
-----
F
-
G
DSFL-
N
N
N
L
I
R
D
V
S
V
-
D
K
D
V
C
V
I
S
V
V
G
A
G
-
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
-
M
-
I
A
Q
G
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
----------------
49
PsiBlast_CBE
63.29
33%
-112
- C1 -
3C20
3
AK_METJA
B:
[119-467]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
S
R
-----
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
-----
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
KR
L
-----
E
V
-
K
-----------------------
E
-
R
L
L
P
-
L
L
K
E
G
I
I
-----
P
V
V
T
G
F
I
G
T
T
E
E
G
Y
-
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
-
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
-
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
-
N
T
F
E
P
E
S
-
E
-
G
T
L
I
T
---
N
D
M
-
E
----
M
S
D
S
I
V
K
---------
A
I
S
T
I
K
N
V
A
L
I
N
I
F
GA
G
--
M
V
G
V
--
S
G
T
A
A
R
I
F
K
A
L
G
-
E
E
E
V
N
V
I
L
I
S
-
Q
G
S
S
-----
E
T
-
N
I
S
L
V
V
-
S
E
E
D
-------
V
---
D
K
A
----------
L
--
K
A
L
K
R
-----
E
-----
F
-
G
DKSFL
N
N
N
L
I
R
D
V
S
V
-
D
K
DVCV
I
S
V
V
G
A
G
-
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
-
M
-
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
----------------