@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0530: (2016-01-08 )
MADALDSLRLMRTQERPAQVFVRGQGSWLWDSDGRAFLDFTQGLAVNCLGHSPSVLVQALARQARELVSAGPGLLNRPVLALAQRLCLATGSDQAYFLTSGAEANEAAIALARKWGRLHRGGAQRIVSTVNSIHGRTPGTLTACGKPAQHGLEGFARVPFNDLDAMAAAIDEETVAVMLEPVQGDAGVIPATLDYLRGIERLCRQRGVLLILDEVQTGIGRCGALLAEELYGVRADIVTLGKGLGAGVPLSALLARGNACCFEPGDQLGTHHGNALMTAAGLAVLNTVLEPGFLEQVREQGTHLRDGLARVARRYGHGPLRGQGLFWGLPLIGQRAPAVVRAAFGEGLLINAPQPHCLRFSPALTVSRANVDEMLRRLERALARVANRHEEVA
Atome Classification :
(39 SA)
----------.........10........20........30........40........50-........60........70.----........80----......---.-..90--.---.-.-......100.......110......-.---120.-..-....130.......140......-.------150-----------------------.-----..----...-------..-------.-------160--------------.---------------------.......170----.-.-------..----.-....180.......190.......200.......210.......220.......230...--....240.....-..250......--.260......----.-----270-.......280.......290.......300.......310....-.--..320.......---330--.---------..---.---..-.------.340..-.....350----..----.....360.......370.......380.......390.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------MA
D
A
L
D
S
L
R
L
M
RTQERP
A
Q
V
F
V
RGQG
S
W
L
WDSDG
R
A
F
L
D
FTQG
L
A
V
N
CLGH-
S
P
S
V
L
V
Q
A
L
A
R
Q
A
R
E
L
V
S
A-G----PGLLN
R
P
V
L
-----
A
L
A
Q
R
L
---
C
-LAT---G---S-D-
Q
A
Y
F
L
TSGAEA
N
E
A
A
I
A
L
A
R
K
W
G
R
L-H---RG
G
A
-
Q
R
-
I
V
S
T
V
N
S
I
HGRTPGTLTACG
K
P
A
-
Q
------
H
-------------------------
G
-----
L
E
----
G
FA-------RV-------P-------F
N
---------------
D
---------------------
L
D
A
M
A
A
AI------D-E-------
E
T
----
V
-
A
V
M
L
EPVQGDAGV
I
P
A
T
L
D
Y
L
R
G
I
E
R
L
C
R
QR
G
V
L
L
I
L
D
E
V
Q
T
G
I
G
R
C
G
A
L
L
A
E
E
L
Y
G
V
R
A
--
D
I
V
T
LGKGLGAG-V
P
L
S
A
L
L
ARGN--ACCFEPGDQL----G-----THH-G
N
A
L
M
T
A
A
G
L
A
V
L
N
T
VLE
P
G
F
L
E
Q
V
R
EQGT
H
L
R
D
G
L
A
R
V
A
R
RYG-H--GPLRGQG
L
F
WGL---PL---I---------GQ---R---A
P
-
A
------
V
V
R
A
AF-GE
G
L
L
INA----PQ----P
H
C
L
RFSP
A
L
T
V
SRA
N
V
D
E
M
L
R
R
L
E
R
A
L
A
R
V
A
N
R
H
EEVA
94
HHSearch
93.08
40%
-105
- C1 -
2ORD
14
ARGD_THEMA
A:
[15-396]
-------------------
L
M
N
T
Y
S
R
F
P
A
T
F
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
Q
A
E
K
L
I
H
C
-
S
----
N
L
F
W
N
R
P
Q
M
-----
E
L
A
E
L
L
---
S
-
K
N
T
---
F
---
G
-
G
-
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
Y
G
K
K
-
K
---
S
E
K
K
-
Y
R
-
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
K
-
Y
------
Q
KPFEP--------------------
L
-----
V
P
----
G
F
E
-------
Y
F
-------
E
-------
F
N
---------------
N
---------------------
V
E
D
L
R
R
K
M
------
S
-
E
-------
D
V
----
C
-
A
V
F
L
E
P
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
--
D
V
L
T
T
A
K
G
L
G
G
G
-
V
P
I
G
A
V
I
V
N
E
R
--
A
N
V
L
E
P
G
D
H
G
----
T
-----
T
F
G
-
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
L
Q
E
M
K
E
E
Y
D
V
V
--
A
D
V
R
G
M
G
L
M
I
G
I
---
Q
F
---
R
---------
E
E
V--
S
---
N
R
-
E
------
V
A
T
K
C
F
-
E
N
K
L
L
V
V
P
----
A
G
----
N
N
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
I
D
L
A
V
E
T
L
K
K
V
L
Q
G
I
--------
1
PsiBlast_PDB
91.95
39%
-104
- C1 -
2E54
5
ARGD_THEMA
A:
[1-382]
-----------------
M
Y
L
M
N
T
Y
S
R
F
P
A
T
F
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
Q
A
E
K
L
I
H
C
-
S
----
N
L
F
W
N
R
P
Q
M
-----
E
L
A
E
L
L
---
S
-
K
N
T
---
F
---
G
-
G
-
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
Y
G
K
K
-
K
---
S
E
K
K
-
Y
R
-
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
K
Y
Q
------
K
-------------------------
P
-----
F
E
PLVP
G
F
E
-------
Y
F
-------
E
-------
F
N
---------------
N
---------------------
V
E
D
L
R
R
K
M
------
S
-
E
-------
D
V
----
C
-
A
V
F
L
E
P
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
--
D
V
L
T
T
A
K
G
L
G
G
G
-
V
P
I
G
A
V
I
V
N
E
R
--
A
N
V
L
E
P
G
D
H
G
----
T
-----
T
F
G
-
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
L
Q
E
M
K
E
E
Y
D
V
V
--
A
D
V
R
G
M
G
L
M
I
G
I
---
Q
F
---
R
---------
E
E
---
V
---
S
N
R
E
------
V
A
T
K
C
F
-
E
N
K
L
L
V
V
P
----
A
G
----
N
N
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
I
D
L
A
V
E
T
L
K
K
V
L
Q
G
I
--------
2
PsiBlast_PDB
91.07
39%
-105
- C1 -
2ORD
14
ARGD_THEMA
A:
[15-394]
-------------------
L
M
N
T
Y
S
R
F
P
A
T
F
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
Q
A
E
K
L
I
H
C
-
S
----
N
L
F
W
N
R
P
Q
M
-----
E
L
A
E
L
L
---
S
-
K
N
T
---
F
---
G
-
G
-
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
Y
G
K
K
-
K
---
S
E
K
K
-
Y
R
-
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
K
Y
Q
------
K
-------------------------
P
-----
F
E
PLVP
G
F
E
-------
Y
F
-------
E
-------
F
N
---------------
N
---------------------
V
E
D
L
R
R
K
M
------
S
-
E
-------
D
V
----
C
-
A
V
F
L
E
P
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
--
D
V
L
T
T
A
K
G
L
G
G
G
-
V
P
I
G
A
V
I
V
N
E
R
--
A
N
V
L
E
P
G
D
H
G
----
T
-----
T
F
G
-
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
L
Q
E
M
K
E
E
Y
D
V
V
--
A
D
V
R
G
M
G
L
M
I
G
I
---
Q
F
---
R
---------
E
E
---
V
---
S
N
R
E
------
V
A
T
K
C
F
-
E
N
K
L
L
V
V
P
----
A
G
----
N
N
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
I
D
L
A
V
E
T
L
K
K
V
L
Q
G
I
--------
30
PsiBlast_CBE
88.32
39%
-106
- C1 -
4ADB
4
ASTC_ECOLI
B:
[26-403]
-------------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
-
G
----
N
G
Y
T
N
E
P
V
L
-----
R
L
A
K
K
L
---
I
-
D
A
T
---
F
---
A
-
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
---
Y
G
S
H
-
K
S
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
------
S
--------------------------------
Q
----
D
F
A
-------
P
L
-------
P
ADIRHAA
Y
N
---------------
D
---------------------
I
N
S
A
S
A
L
I
------
D
-
D
-------
S
T
----
C
-
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
--
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C-
A
R
V
M
T
V
G
T
H
G
----
T
-----
T
Y
G
-
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
--
S
E
V
R
G
L
G
L
L
I
G
C
---
V
L
NAD
Y
---------
A
G
---
Q
---
A
K
-
Q
------
I
S
Q
E
A
A
-
K
A
G
V
M
V
L
I
----
A
G
----
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
R
-----
28
PsiBlast_CBE
87.38
39%
-104
- C1 -
4ADB
3
ASTC_ECOLI
D:
[26-402]
-------------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
-
G
----
N
G
Y
T
N
E
P
V
L
-----
R
L
A
K
K
L
---
I
-
D
A
T
---
F
---
A
-
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
---
Y
G
S
H
-
K
S
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
------
S
--------------------------------
Q
----
D
F
A
-------
P
L
-------
P
ADIRHAA
Y
N
---------------
D
---------------------
I
N
S
A
S
A
L
I
------
D
-
D
-------
S
T
----
C
-
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
--
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C-
A
R
V
M
T
V
G
T
H
G
----
T
-----
T
Y
G
-
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
--
S
E
V
R
G
L
G
L
L
I
G
C
---
V
L
NAD
Y
---------
A
G
---
Q
---
A
K
-
Q
------
I
S
Q
E
A
A
-
K
A
G
V
M
V
L
I
----
A
G
----
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
------
5
PsiBlast_PDB
87.20
39%
-105
- C1 -
4ADC
2
ASTC_ECOLI
A:
[26-402]
-------------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
-
G
----
N
G
Y
T
N
E
P
V
L
-----
R
L
A
K
K
L
---
I
-
D
A
T
---
F
---
A
-
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
---
Y
G
S
H
-
K
S
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
------
S
--------------------------------
Q
----
D
F
A
-------
P
L
-------
P
AD
I
R
H
A
A
Y
N
---------------
D
---------------------
I
N
S
A
S
A
L
I
------
D
-
D
-------
S
T
----
C
-
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
--
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C
-
A
R
V
M
T
V
G
T
H
G
----
T
-----
T
Y
G
-
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
--
S
E
V
R
G
L
G
L
L
I
G
C
---
V
L
N
AD
Y
---------
A
G
---
Q
---
A
K
-
Q
------
I
S
Q
E
A
A
-
K
A
G
V
M
V
L
I
----
A
G
----
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
------
29
PsiBlast_CBE
86.69
39%
-103
- C1 -
4ADB
4
ASTC_ECOLI
C:
[26-402]
-------------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
-
G
----
N
G
Y
T
N
E
P
V
L
-----
R
L
A
K
K
L
---
I
-
D
A
T
---
F
---
A
-
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
---
Y
G
S
H
-
K
S
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
------
S
--------------------------------
Q
----
D
F
A
-------
P
L
-------
P
ADIRHAA
Y
N
---------------
D
---------------------
I
N
S
A
S
A
L
I
------
D
-
D
-------
S
T
----
C
-
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
--
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C-
A
R
V
M
T
V
G
T
H
G
----
T
-----
T
Y
G
-
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
--
S
E
V
R
G
L
G
L
L
I
G
C
---
V
L
NAD
Y
---------
A
G
---
Q
---
A
K
-
Q
------
I
S
Q
E
A
A
-
K
A
G
V
M
V
L
I
----
A
G
----
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
------
22
PsiBlast_CBE
86.66
39%
-103
- C1 -
4ADD
4
ASTC_ECOLI
D:
[26-402]
-------------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
-
G
----
N
G
Y
T
N
E
P
V
L
-----
R
L
A
K
K
L
---
I
-
D
A
T
---
F
---
A
-
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
---
Y
G
S
H
-
K
S
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
------
S
--------------------------------
Q
----
D
F
A
-------
P
L
-------
P
ADIRHAA
Y
N
---------------
D
---------------------
I
N
S
A
S
A
L
I
------
D
-
D
-------
S
T
----
C
-
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
--
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C-
A
R
V
M
T
V
G
T
H
G
----
T
-----
T
Y
G
-
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
--
S
E
V
R
G
L
G
L
L
I
G
C
---
V
L
NAD
Y
---------
A
G
---
Q
---
A
K
-
Q
------
I
S
Q
E
A
A
-
K
A
G
V
M
V
L
I
----
A
G
----
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
------
4
PsiBlast_PDB
86.37
39%
-103
- C1 -
4ADB
4
ASTC_ECOLI
A:
[26-402]
-------------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
-
G
----
N
G
Y
T
N
E
P
V
L
-----
R
L
A
K
K
L
---
I
-
D
A
T
---
F
---
A
-
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
---
Y
G
S
H
-
K
S
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
------
S
--------------------------------
Q
----
D
F
A
-------
P
L
-------
P
AD
I
R
H
A
A
Y
N
---------------
D
---------------------
I
N
S
A
S
A
L
I
------
D
-
D
-------
S
T
----
C
-
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
--
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C
-
A
R
V
M
T
V
G
T
H
G
----
T
-----
T
Y
G
-
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
--
S
E
V
R
G
L
G
L
L
I
G
C
---
V
L
N
AD
Y
---------
A
G
---
Q
---
A
K
-
Q
------
I
S
Q
E
A
A
-
K
A
G
V
M
V
L
I
----
A
G
----
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
------
6
PsiBlast_PDB
86.13
39%
-101
- C1 -
4ADD
4
ASTC_ECOLI
A:
[26-402]
-------------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
-
G
----
N
G
Y
T
N
E
P
V
L
-----
R
L
A
K
K
L
---
I
-
D
A
T
---
F
---
A
-
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
---
Y
G
S
H
-
K
S
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
------
S
--------------------------------
Q
----
D
F
A
-------
P
L
-------
P
AD
I
R
H
A
A
Y
N
---------------
D
---------------------
I
N
S
A
S
A
L
I
------
D
-
D
-------
S
T
----
C
-
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
--
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C
-
A
R
V
M
T
V
G
T
H
G
----
T
-----
T
Y
G
-
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
--
S
E
V
R
G
L
G
L
L
I
G
C
---
V
L
N
AD
Y
---------
A
G
---
Q
---
A
K
-
Q
------
I
S
Q
E
A
A
-
K
A
G
V
M
V
L
I
----
A
G
----
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
------
25
PsiBlast_CBE
85.97
39%
-103
- C1 -
4ADC
2
ASTC_ECOLI
D:
[26-402]
-------------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
-
G
----
N
G
Y
T
N
E
P
V
L
-----
R
L
A
K
K
L
---
I
-
D
A
T
---
F
---
A
-
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
---
Y
G
S
H
-
K
S
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
------
S
--------------------------------
Q
----
D
F
A
-------
P
L
-------
P
ADIRHAA
Y
N
---------------
D
---------------------
I
N
S
A
S
A
L
I
------
D
-
D
-------
S
T
----
C
-
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
--
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C-
A
R
V
M
T
V
G
T
H
G
----
T
-----
T
Y
G
-
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
--
S
E
V
R
G
L
G
L
L
I
G
C
---
V
L
NAD
Y
---------
A
G
---
Q
---
A
K
-
Q
------
I
S
Q
E
A
A
-
K
A
G
V
M
V
L
I
----
A
G
----
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
------
3
PsiBlast_PDB
85.75
37%
-99
- C1 -
2EH6
2
ARGD_AQUAE
A:
[3-375]
-------------------
L
M
N
N
Y
A
R
L
P
V
K
F
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
-
A
Y
P
K
L
T
E
A
L
K
E
Q
V
E
K
L
L
H
V
-
S
----
N
L
Y
E
N
P
W
Q
E
-----
E
L
A
H
K
L
---
V
-
K
H
F
---
W
---
T
-
E
G
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
W
R
D
-
K
---
G
K
N
K
-
W
K
-
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
Q
P
K
-
F
------
H
K------------------------
G
-----
F
E
PLV
P
G
F
S
-------
Y
A
-------
K
-------
L
N
---------------
D
---------------------
I
D
S
V
Y
K
L
L
------
D
-
E
-------
E
T
----
A
-
G
I
I
I
E
V
I
Q
G
E
G
G
V
N
E
A
S
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
--
D
V
I
A
L
A
K
G
L
G
G
G
-
V
P
I
G
A
I
L
A
R
E
E
V-
A
Q
S
F
T
P
G
S
H
G
----
S
-----
T
F
G
-
G
N
P
L
A
C
R
A
G
T
V
V
V
D
E
V
--
E
K
L
L
P
H
V
R
E
V
G
N
Y
F
K
E
K
L
----
K
E
L
G
-
K
--
G
K
V
K
G
R
G
L
M
L
G
L
---
E
L
---
E
---------
R
E
---
C
---
K
D
-
Y
------
V
L
K
-
A
L
-
E
K
G
L
L
I
N
C
----
T
A
----
G
K
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
I
L
-----------
23
PsiBlast_CBE
85.40
39%
-103
- C1 -
4ADD
4
ASTC_ECOLI
C:
[26-402]
-------------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
-
G
----
N
G
Y
T
N
E
P
V
L
-----
R
L
A
K
K
L
---
I
-
D
A
T
---
F
---
A
-
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
---
Y
G
S
H
-
K
S
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
------
S
--------------------------------
Q
----
D
F
A
-------
P
L
-------
P
ADIRHAA
Y
N
---------------
D
---------------------
I
N
S
A
S
A
L
I
------
D
-
D
-------
S
T
----
C
-
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
--
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C-
A
R
V
M
T
V
G
T
H
G
----
T
-----
T
Y
G
-
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
--
S
E
V
R
G
L
G
L
L
I
G
C
---
V
L
NAD
Y
---------
A
G
---
Q
---
A
K
-
Q
------
I
S
Q
E
A
A
-
K
A
G
V
M
V
L
I
----
A
G
----
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
------
24
PsiBlast_CBE
84.72
39%
-105
- C1 -
4ADD
4
ASTC_ECOLI
B:
[26-402]
-------------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
-
G
----
N
G
Y
T
N
E
P
V
L
-----
R
L
A
K
K
L
---
I
-
D
A
T
---
F
---
A
-
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
---
Y
G
S
H
-
K
S
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
------
S
--------------------------------
Q
----
D
F
A
-------
P
L
-------
P
ADIRHAA
Y
N
---------------
D
---------------------
I
N
S
A
S
A
L
I
------
D
-
D
-------
S
T
----
C
-
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
--
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C-
A
R
V
M
T
V
G
T
H
G
----
T
-----
T
Y
G
-
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
--
S
E
V
R
G
L
G
L
L
I
G
C
---
V
L
NAD
Y
---------
A
G
---
Q
---
A
K
-
Q
------
I
S
Q
E
A
A
-
K
A
G
V
M
V
L
I
----
A
G
----
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
------
21
PsiBlast_CBE
84.41
37%
-101
- C1 -
2EH6
2
ARGD_AQUAE
B:
[3-375]
-------------------
L
M
N
N
Y
A
R
L
P
V
K
F
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
-
A
Y
P
K
L
T
E
A
L
K
E
Q
V
E
K
L
L
H
V
-
S
----
N
L
Y
E
N
P
W
Q
E
-----
E
L
A
H
K
L
---
V
-
K
H
F
---
W
---
T
-
E
G
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
W
R
D
-
K
---
G
K
N
K
-
W
K
-
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
Q
P
K
-
F
------
H
K------------------------
G
-----
F
E
PLVP
G
F
S
-------
Y
A
-------
K
-------
L
N
---------------
D
---------------------
I
D
S
V
Y
K
L
L
------
D
-
E
-------
E
T
----
A
-
G
I
I
I
E
V
I
Q
G
E
G
G
V
N
E
A
S
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
--
D
V
I
A
L
A
K
G
L
G
G
G
-
V
P
I
G
A
I
L
A
R
E
E
V-
A
Q
S
F
T
P
G
S
H
G
----
S
-----
T
F
G
-
G
N
P
L
A
C
R
A
G
T
V
V
V
D
E
V
--
E
K
L
L
P
H
V
R
E
V
G
N
Y
F
K
E
K
L
----
K
E
L
G
-
K
--
G
K
V
K
G
R
G
L
M
L
G
L
---
E
L
---
E
---------
R
E
---
C
---
K
D
-
Y
------
V
L
K
-
A
L
-
E
K
G
L
L
I
N
C
----
T
A
----
G
K
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
I
L
-----------
27
PsiBlast_CBE
84.21
39%
-105
- C1 -
4ADC
4
ASTC_ECOLI
B:
[26-402]
-------------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
-
G
----
N
G
Y
T
N
E
P
V
L
-----
R
L
A
K
K
L
---
I
-
D
A
T
---
F
---
A
-
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
---
Y
G
S
H
-
K
S
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
------
S
--------------------------------
Q
----
D
F
A
-------
P
L
-------
P
ADIRHAA
Y
N
---------------
D
---------------------
I
N
S
A
S
A
L
I
------
D
-
D
-------
S
T
----
C
-
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
--
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C-
A
R
V
M
T
V
G
T
H
G
----
T
-----
T
Y
G
-
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
--
S
E
V
R
G
L
G
L
L
I
G
C
---
V
L
NAD
Y
---------
A
G
---
Q
---
A
K
-
Q
------
I
S
Q
E
A
A
-
K
A
G
V
M
V
L
I
----
A
G
----
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
------
26
PsiBlast_CBE
84.11
39%
-103
- C1 -
4ADC
3
ASTC_ECOLI
C:
[26-402]
-------------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
-
G
----
N
G
Y
T
N
E
P
V
L
-----
R
L
A
K
K
L
---
I
-
D
A
T
---
F
---
A
-
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
---
Y
G
S
H
-
K
S
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
------
S
--------------------------------
Q
----
D
F
A
-------
P
L
-------
P
ADIRHAA
Y
N
---------------
D
---------------------
I
N
S
A
S
A
L
I
------
D
-
D
-------
S
T
----
C
-
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
--
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C-
A
R
V
M
T
V
G
T
H
G
----
T
-----
T
Y
G
-
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
--
S
E
V
R
G
L
G
L
L
I
G
C
---
V
L
NAD
Y
---------
A
G
---
Q
---
A
K
-
Q
------
I
S
Q
E
A
A
-
K
A
G
V
M
V
L
I
----
A
G
----
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
------
85
HHSearch
83.58
28%
-114
- C1 -
1Z7D
-
OAT_PLAYO
A:
[22-410]
---------------------
H
N
Y
D
P
I
P
V
V
L
K
R
A
K
G
V
F
V
Y
D
V
N
D
K
R
Y
Y
D
F
L
S
A
Y
S
S
V
N
Q
G
H
-
C
H
P
N
I
L
N
A
M
I
N
Q
A
K
N
L
T
I
C
-
S
----
R
A
F
F
S
V
P
L
G
-----
I
C
E
R
Y
L
---
T
-
N
L
L
---
G
---
Y
-
D
-
K
V
L
M
M
N
T
G
A
E
A
N
E
T
A
Y
K
L
C
R
K
W
G
Y
E
-
V
KKI
P
E
N
M
-
A
K
-
I
V
V
C
K
N
N
--------------------------------------------------------------
Q
F
S
-------
K
V
-------
P
-------
Y
D
---------------
D
---------------------
L
E
A
L
E
E
E
L
------
K
D
P
-------
N
V
----
C
-
A
F
I
V
E
P
I
Q
G
E
A
G
V
I
V
P
S
D
N
Y
L
Q
G
V
Y
D
I
C
K
K
Y
N
V
L
F
V
A
D
E
V
Q
T
G
L
G
R
T
G
K
L
L
C
V
H
H
Y
N
V
K
P
--
D
V
I
L
L
G
K
A
L
S
G
G
H
Y
P
I
S
A
V
L
A
N
D
D
I-
M
L
V
I
K
P
G
E
H
G
----
S
-----
T
Y
G
-
G
N
P
L
A
A
S
I
C
V
E
A
L
N
V
L
I
N
E
K
L
C
E
N
A
E
K
L
G
G
P
F
L
E
N
L
K
R
E
L
K
D
S
K
I
V
--
R
D
V
R
G
K
G
L
L
C
A
I
---
E
F
---
K
---------
N
E
LV-
N
---
V
L
-
D
------
I
C
L
K
L
K
-
E
N
G
L
I
T
R
D
----
V
H
----
D
K
T
I
R
L
T
P
P
L
C
I
T
K
E
Q
L
D
E
C
T
E
I
I
V
K
T
V
K
F
F
D
-------
7
PsiBlast_PDB
82.53
39%
-102
- C1 -
4ADE
-
ASTC_ECOLI
A:
[26-402]
-------------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
-
G
----
N
G
Y
T
N
E
P
V
L
-----
R
L
A
K
K
L
---
I
-
D
A
T
---
F
---
A
-
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
---
Y
G
S
H
-
K
S
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
------
S
--------------------------------
Q
----
D
F
A
-------
P
L
-------
P
AD
I
R
H
A
A
Y
N
---------------
D
---------------------
I
N
S
A
S
A
L
I
------
D
-
D
-------
S
T
----
C
-
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
--
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C
-
A
R
V
M
T
V
G
T
H
G
----
T
-----
T
Y
G
-
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
--
S
E
V
R
G
L
G
L
L
I
G
C
---
V
L
N
AD
Y
---------
A
G
---
Q
---
A
K
-
Q
------
I
S
Q
E
A
A
-
K
A
G
V
M
V
L
I
----
A
G
----
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
------
13
PsiBlast_PDB
80.97
35%
-102
- C1 -
4JEZ
14
ARGD_SALTY
A:
[44-418]
-------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
-
S
----
R
V
F
T
N
E
P
A
L
-----
R
L
G
R
K
L
---
I
-
D
A
T
---
F
---
A
-
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
---
S
P
F
K
-
T
K
-
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
------
S
--------------------------------
D
----
G
F
G
PKPAD
I
I
H
V
-------
P
-------
F
N
---------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
-------
H
T
----
C
-
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
--
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
-
A
S
A
F
-----
G
----
S
-----
T
Y
G
-
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
--
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
---
Y
---------
K
G
---
R
---
A
R
-
D
------
F
L
Y
A
G
A
-
E
A
G
V
M
V
L
N
----
A
G
----
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
L
-----
34
PsiBlast_CBE
79.36
35%
-99
- C1 -
4JEW
13
ARGD_SALTY
B:
[44-418]
-------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
-
S
----
N
V
F
T
N
E
P
A
L
-----
R
L
G
R
K
L
---
I
-
D
A
T
---
F
---
A
-
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
---
S
P
F
K
-
T
K
-
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
------
S
--------------------------------
D
----
G
F
G
PKPAD
I
I
H
V
-------
P
-------
F
N
---------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
-------
H
T
----
C
-
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
--
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
-
A
S
A
F
H
V
G
S
H
G
----
S
-----
T
Y
G
-
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
--
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
---
Y
---------
K
G
---
R
---
A
R
-
D
------
F
L
Y
A
G
A
-
E
A
G
V
M
V
L
N
----
A
G
----
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
-------
35
PsiBlast_CBE
78.91
35%
-102
- C1 -
4JEZ
13
ARGD_SALTY
B:
[44-418]
-------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
-
S
----
R
V
F
T
N
E
P
A
L
-----
R
L
G
R
K
L
---
I
-
D
A
T
---
F
---
A
-
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
---
S
P
F
K
-
T
K
-
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
------
S
--------------------------------
D
----
G
F
G
PKPAD
I
I
H
V
-------
P
-------
F
N
---------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
-------
H
T
----
C
-
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
--
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
-
A
S
A
F
-----
G
----
S
-----
T
Y
G
-
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
--
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
---
Y
---------
K
G
---
R
---
A
R
-
D
------
F
L
Y
A
G
A
-
E
A
G
V
M
V
L
N
----
A
G
----
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
------
36
PsiBlast_CBE
78.17
35%
-98
- C1 -
4JEY
13
ARGD_SALTY
B:
[44-418]
-------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
-
S
----
N
V
F
T
N
E
P
A
L
-----
R
L
G
R
K
L
---
I
-
D
A
T
---
F
---
A
-
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
---
S
P
F
K
-
T
K
-
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
------
S
--------------------------------
D
----
G
F
G
PKPAD
I
I
H
V
-------
P
-------
F
N
---------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
-------
H
T
----
C
-
A
V
V
V
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
--
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
-
A
S
A
F
H
V
G
S
H
G
----
S
-----
T
Y
G
-
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
--
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
---
Y
---------
K
G
---
R
---
A
R
-
D
------
F
L
Y
A
G
A
-
E
A
G
V
M
V
L
N
----
A
G
----
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
------
37
PsiBlast_CBE
76.33
34%
-100
- C1 -
4JF1
9
ARGD_SALTY
B:
[44-418]
-------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
-
S
----
N
V
F
T
N
E
P
A
L
-----
R
L
G
R
K
L
---
I
-
D
A
T
---
F
---
A
-
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
---
S
P
F
K
-
T
K
-
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
------
S
--------------------------------
D
----
G
F
G
PKPAD
I
I
H
V
-------
P
-------
F
N
---------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
-------
H
T
----
C
-
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
--
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
-
A
S
A
F
H
V
G
S
H
G
----
S
-----
T
Y
G
-
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
--
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
---
Y
---------
K
G
---
R
---
A
R
-
D
------
F
L
Y
A
G
A
-
E
A
G
V
M
V
L
N
----
A
G
----
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
-------
46
PsiBlast_CBE
75.92
34%
-97
- C1 -
2DKB
4
DGDA_BURCE
A:
[27-431]
----------------------------
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
D
G
R
A
I
L
D
F
T
S
G
Q
M
S
A
V
L
G
H
-
C
H
P
E
I
V
S
V
I
G
E
Y
A
G
K
L
D
H
L
-
F
----
S
E
M
L
S
R
P
V
V
-----
D
L
A
T
R
L
---
A
-
N
I
T
PP-
G
---
L
-
D
-
R
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
T
---------
G
K
-
Y
E
-
I
V
G
F
A
Q
S
W
H
G
M
T
G
A
A
A
S
A
T
Y
S
A
G
-
R
------
K
-------------------------
G
-----
V
-----
G
P
A
-------
A
V
G
S
F
A
I
P
A
P
-------
F
T
YRPRFERNGAYD
Y
L
A
E
---------------------
L
D
Y
A
F
D
L
I
------
D
-
R
-------
Q
S
SGNL
A
-
A
F
I
A
E
P
I
L
S
S
G
G
I
I
E
L
P
D
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
T
M
F
A
C
Q
R
D
G
V
T
P
--
D
I
L
T
L
S
K
T
L
G
A
G
-
L
P
L
A
A
I
V
T
--
S
--
A
A
I
E
E
R
A
H
E
L
----
G
Y
L
F
Y
T
T
H
V
-
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
G
L
V
A
R
A
N
V
M
G
D
R
L
R
R
G
L
L
D
L
M
E
R
F
D
C
I
--
G
D
V
R
G
R
G
L
L
L
G
V
---
E
I
---
V
---------
K
D
---
R
RTK
E
P
-
A
DG
L
G
A
K
I
T
R
E
C
M
-
N
L
G
L
S
M
N
I
----
V
Q
L
PGM
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
E
R
A
L
-------
87
HHSearch
75.91
34%
-100
* C1 *
1VEF
2
ARGD_THET8
A:
[26-395]
-------------------------
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
-
P
----
Q
T
L
P
T
P
M
R
G
-----
E
F
Y
R
T
L
---
T
-
A
I
L
---
P
PE-
L
-
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
---------
G
R
-
K
K
-
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
-
Y
REPFL-
P
-------------------------
L
-----
V
E
----
P
V
E
-------
F
I
-------
P
-------
Y
N
---------------
D
---------------------
V
E
A
L
K
R
A
V
------
D
-
E
-------
E
T
----
A
-
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
--
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
V
-
A
R
S
M
P
K
G
G
H
G
----
T
-----
T
F
G
-
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
-
K
-
I
--
R
E
V
R
G
M
G
L
M
V
G
L
---
E
L
---
K
---------
E
K
-------
A
A
-
P
------
Y
I
A
R
L
E
K
E
H
R
V
L
A
L
Q
----
A
G
----
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
----------
86
HHSearch
73.84
30%
-102
- C1 -
2OAT
2
OAT_HUMAN
A:
[54-438]
----------------------
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
-
S
----
R
A
F
Y
N
N
V
L
G
-----
E
Y
E
E
Y
I
---
T
-
K
L
F
---
N
---
Y
-
H
-
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
-
V
KGI
Q
K
Y
K
-
A
K
-
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
-
S
YDGF--
G
P------------------------
F
-----
M
P
----
G
F
D
-------
I
I
-------
P
-------
Y
N
---------------
D
---------------------
L
P
A
L
E
R
A
L
------
Q
D
P
-------
N
V
----
A
-
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
--
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
A
V
L
C
D
D
D
I
-
M
L
T
I
K
P
G
E
H
G
----
S
-----
T
Y
G
-
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
D
V
--
V
--
T
A
V
R
G
K
G
L
L
N
A
I
---
V
I
---
K
---------
E
T
KDW
D
---
A
W
-
K
------
V
C
L
R
L
R
-
D
N
G
L
L
A
K
P
----
T
H
----
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
L
S
F
--------
44
PsiBlast_CBE
73.21
34%
-99
- C1 -
1DGD
4
DGDA_BURCE
A:
[26-430]
----------------------------
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
D
G
R
A
I
L
D
F
T
S
G
Q
M
S
A
V
L
G
H
-
C
H
P
E
I
V
S
V
I
G
E
Y
A
G
K
L
D
H
L
-
F
----
S
G
M
L
S
R
P
V
V
-----
D
L
A
T
R
L
---
A
-
N
I
T
PP-
G
---
L
-
D
-
R
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
T
---------
G
K
-
Y
E
-
I
V
G
F
A
Q
S
W
H
G
M
T
G
A
A
A
S
A
T
Y
S
A
G
-
R
------
K
-------------------------
G
-----
V
-----
G
P
A
-------
A
V
G
S
F
A
I
P
A
P
-------
F
T
YRPRFERNGAYD
Y
L
A
E
---------------------
L
D
Y
A
F
D
L
I
------
D
-
R
-------
Q
S
SGNL
A
-
A
F
I
A
E
P
I
L
S
S
G
G
I
I
E
L
P
D
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
T
M
F
A
C
Q
R
D
G
V
T
P
--
D
I
L
T
L
S
K
T
L
G
A
G
-
L
P
L
A
A
I
V
T
--
S
--
A
A
I
E
E
R
A
H
E
L
----
G
Y
L
F
Y
T
T
H
V
-
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
G
L
V
A
R
A
N
V
M
G
D
R
L
R
R
G
L
L
D
L
M
E
R
F
D
C
I
--
G
D
V
R
G
R
G
L
L
L
G
V
---
E
I
---
V
---------
K
D
---
R
RTK
E
P
-
A
DG
L
G
A
K
I
T
R
E
C
M
-
N
L
G
L
S
M
N
I
----
V
Q
L
PGM
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
E
R
A
L
-------
54
PsiBlast_CBE
72.84
34%
-99
- C1 -
1DKA
4
DGDA_BURCE
A:
[27-431]
----------------------------
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
D
G
R
A
I
L
D
F
T
S
G
Q
M
S
A
V
L
G
H
-
C
H
P
E
I
V
S
V
I
G
E
Y
A
G
K
L
D
H
L
-
F
----
S
E
M
L
S
R
P
V
V
-----
D
L
A
T
R
L
---
A
-
N
I
T
PP-
G
---
L
-
D
-
R
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
T
---------
G
K
-
Y
E
-
I
V
G
F
A
Q
S
W
H
G
M
T
G
A
A
A
S
A
T
Y
S
A
G
-
R
------
K
-------------------------
G
-----
V
-----
G
P
A
-------
A
V
G
S
F
A
I
P
A
P
-------
F
T
YRPRFERNGAYD
Y
L
A
E
---------------------
L
D
Y
A
F
D
L
I
------
D
-
R
-------
Q
S
SGNL
A
-
A
F
I
A
E
P
I
L
S
S
G
G
I
I
E
L
P
D
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
T
M
F
A
C
Q
R
D
G
V
T
P
--
D
I
L
T
L
S
K
T
L
G
A
G
-
L
P
L
A
A
I
V
T
--
S
--
A
A
I
E
E
R
A
H
E
L
----
G
Y
L
F
Y
T
T
H
V
-
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
G
L
V
A
R
A
N
V
M
G
D
R
L
R
R
G
L
L
D
L
M
E
R
F
D
C
I
--
G
D
V
R
G
R
G
L
L
L
G
V
---
E
I
---
V
---------
K
D
---
R
RTK
E
P
-
A
DG
L
G
A
K
I
T
R
E
C
M
-
N
L
G
L
S
M
N
I
----
V
Q
L
P
GM
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
E
R
A
L
-------
43
PsiBlast_CBE
72.05
34%
-98
- C1 -
1DGE
4
DGDA_BURCE
A:
[26-430]
----------------------------
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
D
G
R
A
I
L
D
F
T
S
G
Q
M
S
A
V
L
G
H
-
C
H
P
E
I
V
S
V
I
G
E
Y
A
G
K
L
D
H
L
-
F
----
S
G
M
L
S
R
P
V
V
-----
D
L
A
T
R
L
---
A
-
N
I
T
PP-
G
---
L
-
D
-
R
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
T
---------
G
K
-
Y
E
-
I
V
G
F
A
Q
S
W
H
G
M
T
G
A
A
A
S
A
T
Y
S
A
G
-
R
------
K
-------------------------
G
-----
V
-----
G
P
A
-------
A
V
G
S
F
A
I
P
A
P
-------
F
T
YRPRFERNGAYD
Y
L
A
E
---------------------
L
D
Y
A
F
D
L
I
------
D
-
R
-------
Q
S
SGNL
A
-
A
F
I
A
E
P
I
L
S
S
G
G
I
I
E
L
P
D
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
T
M
F
A
C
Q
R
D
G
V
T
P
--
D
I
L
T
L
S
K
T
L
G
A
G
-
L
P
L
A
A
I
V
T
--
S
--
A
A
I
E
E
R
A
H
E
L
----
G
YLFYT
T
H
V
-
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
G
L
V
A
R
A
N
V
M
G
D
R
L
R
R
G
L
L
D
L
M
E
R
F
D
C
I
--
G
D
V
R
G
R
G
L
L
L
G
V
---
E
I
---
V
---------
K
D
---
R
RTK
E
P
-
A
DG
L
G
A
K
I
T
R
E
C
M
-
N
L
G
L
S
M
N
I
----
V
Q
L
P
GM
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
E
R
A
L
-------
79
Fugue
71.96
34%
-101
- C1 -
1D7U
3
DGDA_BURCE
A:
[3-433]
LNDD
A
T
F
W
R
N
A
R
Q
H
L
V
R
Y
G
G
----
T
F
E
P
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
D
G
R
A
I
L
D
F
T
S
G
Q
M
S
A
V
L
G
H
-
C
H
P
E
I
V
S
V
I
G
-
E
Y
A
G
K
L
---
D
HLFS
G
-
M
L
S
R
P
V
V
-----
D
L
A
T
-
R
---
L
-
A
N
I
TPP
G
---
L
-
D
-
R
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
T
--------
G
--
K
Y
E
-
I
V
G
F
A
Q
S
W
H
G
M
T
G
A
A
A
S
A
T
Y
S
A
--
G
-------RKGVGPAAVG
S
F
A
I
P
APFTYRPRFE
R
---------------------
N
G
-------
A
-------
Y
D
---------------
Y
---------------------
L
A
E
L
D
Y
A
F
------
D
-
L
I
D
R
Q
SSG
N
L
----
A
-
A
F
I
A
E
P
I
L
S
S
G
G
I
I
E
L
P
D
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
T
M
F
A
C
Q
R
D
G
--
V
TP
D
I
L
T
L
S
K
T
L
G
A
G
L
-
P
L
A
A
I
V
T
S
A
A
--
I
E
E
R
A
H
E
L
------
G
YLFYT
T
H
V
-
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
G
L
V
A
R
A
N
V
M
G
D
R
L
R
R
G
L
L
D
L
M
E
R
F
--
D
CI
G
D
V
R
G
R
G
L
L
L
G
V
---
E
I
---
V
KDRRTKEPA
D
G
---
L
---
G
A
-
K
------
I
T
R
E
C
M
-
N
L
G
L
S
M
N
I
V
Q
L
P
G
M
----
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
E
R
A
L
-------
40
PsiBlast_CBE
71.59
34%
-97
- C1 -
1VEF
2
ARGD_THET8
B:
[30-395]
-----------------------------
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
-
E
T
L
M
A
-
M
----
P
Q
T
L
P
T
P
M
R
-----
G
E
F
Y
R
T
LTA
I
-
L
P
P
---
E
---
L
-
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
---------
H
T
G
R
-
K
K
-
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
-
Y
------
R
-------------------------
E
PFLPL
V
E
----
P
V
E
-------
F
I
-------
P
-------
Y
N
---------------
D
---------------------
V
E
A
L
K
R
A
V
------
D
-
E
-------
E
T
----
A
-
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
--
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
--
V
A
R
S
M
P
K
G
G
H
----
G
-----
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
-
R
A
I
P
S
P
K
-
I
--
R
E
V
R
G
M
G
L
M
V
G
L
---
E
L
---
K
---------
E
K
---
A
---
A
P
-
Y
------
I
A
R
L
E
K
-
E
H
R
V
L
A
L
Q
----
A
G
----
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
----------
48
PsiBlast_CBE
71.40
34%
-97
- C1 -
1ZOB
4
DGDA_BURCE
A:
[27-431]
----------------------------
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
D
G
R
A
I
L
D
F
T
S
G
Q
M
S
A
V
L
G
H
-
C
H
P
E
I
V
S
V
I
G
E
Y
A
G
K
L
D
H
L
-
F
----
S
E
M
L
S
R
P
V
V
-----
D
L
A
T
R
L
---
A
-
N
I
T
PP-
G
---
L
-
D
-
R
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
T
---------
G
K
-
Y
E
-
I
V
G
F
A
Q
S
W
H
G
M
T
G
A
A
A
S
A
T
Y
S
A
G
-
R
------
K
-------------------------
G
-----
V
-----
G
P
A
-------
A
V
G
S
F
A
I
P
A
P
-------
F
T
YRPRFERNGAYD
Y
L
A
E
---------------------
L
D
Y
A
F
D
L
I
------
D
-
R
-------
Q
S
SGNL
A
-
A
F
I
A
E
P
I
L
S
S
G
G
I
I
E
L
P
D
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
T
M
F
A
C
Q
R
D
G
V
T
P
--
D
I
L
T
L
S
K
T
L
G
A
G
-
L
P
L
A
A
I
V
T
--
S
--
A
A
I
E
E
R
A
H
E
L
----
G
Y
L
F
Y
T
T
H
V
-
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
G
L
V
A
R
A
N
V
M
G
D
R
L
R
R
G
L
L
D
L
M
E
R
F
D
C
I
--
G
D
V
R
G
R
G
L
L
L
G
V
---
E
I
---
V
---------
K
D
---
R
RTK
E
P
-
A
DG
L
G
A
K
I
T
R
E
C
M
-
N
L
G
L
S
M
N
I
----
V
Q
L
P
GM
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
E
R
A
L
-------
38
PsiBlast_CBE
71.29
34%
-94
- C1 -
1WKH
2
ARGD_THET8
B:
[30-395]
-----------------------------
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
-
E
T
L
M
A
-
M
----
P
Q
T
L
P
T
P
M
R
-----
G
E
F
Y
R
T
LTA
I
-
L
P
P
---
E
---
L
-
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
---------
H
T
G
R
-
K
K
-
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
-
Y
------
R
-------------------------
E
PFLPL
V
E
----
P
V
E
-------
F
I
-------
P
-------
Y
N
---------------
D
---------------------
V
E
A
L
K
R
A
V
------
D
-
E
-------
E
T
----
A
-
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
--
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
--
V
A
R
S
M
P
K
G
G
H
----
G
-----
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
-
R
A
I
P
S
P
K
-
I
--
R
E
V
R
G
M
G
L
M
V
G
L
---
E
L
---
K
---------
E
K
---
A
---
A
P
-
Y
------
I
A
R
L
E
K
-
E
H
R
V
L
A
L
Q
----
A
G
----
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
----------
41
PsiBlast_CBE
71.04
34%
-99
- C1 -
1D7V
3
DGDA_BURCE
A:
[27-431]
----------------------------
M
I
I
E
R
A
K
G
S
F
V
Y
D
A
D
G
R
A
I
L
D
F
T
S
G
Q
M
S
A
V
L
G
H
-
C
H
P
E
I
V
S
V
I
G
E
Y
A
G
K
L
D
H
L
-
F
----
S
G
M
L
S
R
P
V
V
-----
D
L
A
T
R
L
---
A
-
N
I
T
PP-
G
---
L
-
D
-
R
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
V
T
---------
G
K
-
Y
E
-
I
V
G
F
A
Q
S
W
H
G
M
T
G
A
A
A
S
A
T
Y
S
A
G
-
R
------
K
-------------------------
G
-----
V
-----
G
P
A
-------
A
V
G
S
F
A
I
P
A
P
-------
F
T
YRPRFERNGAYD
Y
L
A
E
---------------------
L
D
Y
A
F
D
L
I
------
D
-
R
-------
Q
S
SGNL
A
-
A
F
I
A
E
P
I
L
S
S
G
G
I
I
E
L
P
D
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
T
M
F
A
C
Q
R
D
G
V
T
P
--
D
I
L
T
L
S
K
T
L
G
A
G
-
L
P
L
A
A
I
V
T
--
S
--
A
A
I
E
E
R
A
H
E
L
----
G
YLFYT
T
H
V
-
S
D
P
L
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
G
L
V
A
R
A
N
V
M
G
D
R
L
R
R
G
L
L
D
L
M
E
R
F
D
C
I
--
G
D
V
R
G
R
G
L
L
L
G
V
---
E
I
---
V
---------
K
D
---
R
RTK
E
P
-
A
DG
L
G
A
K
I
T
R
E
C
M
-
N
L
G
L
S
M
N
I
----
V
Q
L
PGM
G
G
V
F
R
I
A
P
P
L
T
V
S
E
D
E
I
D
L
G
L
S
L
L
G
Q
A
I
E
R
A
L
-------
107
HHSearch
70.32
32%
-99
- C1 -
2EO5
3
?
A:
[23-418]
-------------------------
L
F
P
L
V
I
D
H
G
E
G
V
W
I
Y
D
V
D
G
N
K
Y
L
D
F
T
S
G
I
G
V
N
N
L
G
W
P
S
H
P
E
V
I
K
I
G
I
E
Q
M
Q
K
L
A
H
A
A
A
----
N
D
F
Y
N
I
P
Q
L
-----
E
L
A
K
K
L
---
V
-
T
Y
S
---
P
GN
F
Q
-
K
-
K
V
F
F
S
N
S
G
T
E
A
I
E
A
S
I
K
V
V
K
N
-
T
---------
G
R
-
K
Y
-
I
I
A
F
L
G
G
F
H
G
R
T
F
G
S
I
S
L
T
A
S
K
A
-
V
QRSIVG
P
-------------------------
F
-----
M
P
----
G
V
I
-------
H
V
-------
P
-------
Y
P
---------------
N
PYRNPWHINGYEN
P
S
E
L
V
N
R
V
I
E
F
I
E
D
Y
I
FVNLVP
P
-
E
-------
E
V
----
A
-
G
I
F
F
E
P
I
Q
G
E
G
G
Y
V
I
P
P
K
N
F
F
A
E
L
Q
K
L
A
K
K
Y
G
I
L
L
V
D
D
E
V
Q
M
G
L
G
R
T
G
K
L
F
A
I
E
N
F
N
T
V
P
--
D
V
I
T
L
A
K
A
L
G
G
G
I
M
P
I
G
A
T
I
F
R
K
D
--
L
D
-
F
K
---------------
T
F
G
-
G
N
A
L
A
C
A
I
G
S
K
V
I
D
I
V
K
--
D
L
L
P
H
V
N
E
I
G
K
I
F
A
E
E
L
Q
G
L
A
---
D
-----
D
V
R
G
I
G
L
A
W
G
L
---
E
Y
---
N
---------
E
K
K
--
V
---
R
D
-
R
------
I
I
G
E
S
F
-
K
R
G
L
L
L
L
P
----
A
G
----
R
S
A
I
R
V
I
P
P
L
V
I
S
E
E
E
A
K
Q
G
L
D
I
L
K
K
V
I
K
V
V
--------
39
PsiBlast_CBE
67.69
34%
-93
- C1 -
1WKG
2
ARGD_THET8
B:
[30-395]
-----------------------------
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
-
E
T
L
M
A
-
M
----
P
Q
T
L
P
T
P
M
R
-----
G
E
F
Y
R
T
LTA
I
-
L
P
P
---
E
---
L
-
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
---------
H
T
G
R
-
K
K
-
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
-
Y
------
R
-------------------------
E
PFLPL
V
E
----
P
V
E
-------
F
I
-------
P
-------
Y
N
---------------
D
---------------------
V
E
A
L
K
R
A
V
------
D
-
E
-------
E
T
----
A
-
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
--
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
--
V
A
R
S
M
P
K
G
G
H
----
G
-----
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
-
R
A
I
P
S
P
K
-
I
--
R
E
V
R
G
M
G
L
M
V
G
L
---
E
L
---
K
---------
E
K
---
A
---
A
P
-
Y
------
I
A
R
L
E
K
-
E
H
R
V
L
A
L
Q
----
A
G
----
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
----------
63
PsiBlast_CBE
50.14
33%
-102
- C1 -
4PPM
3
?
B:
[407-740]
--------------
V
D
F
L
K
L
Q
R
C
D
----
N
V
F
R
S
A
A
G
T
Q
L
Y
D
D
A
G
E
A
F
L
D
M
V
A
G
Y
G
C
L
N
L
G
H
-
N
P
Q
P
V
V
N
A
L
K
N
Y
---
L
D
A
Q
-
G
----
P
N
F
I
Q
Y
I
S
I
PEQTA
K
L
A
E
V
L
---
C
R
L
A
P
---
G
---
N
M
G
-
R
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
A
---------
S
T
G
K
-
P
G
-
I
A
Y
L
R
N
S
Y
H
G
K
T
L
G
A
L
S
I
T
G
R
D
K
-
H
------
R
-------------------------
R
YFTPL
L
D
----
A
M
V
-------
E
V
-------
P
-------
F
G
---------------
D
---------------------
L
A
A
L
R
E
A
L
------
N
-
R
-------
E
D
----
V
G
A
L
M
I
E
P
I
Q
G
E
G
G
V
H
I
P
P
A
G
Y
L
Q
A
V
Q
Q
L
C
R
E
T
G
V
L
L
M
V
D
E
V
Q
T
G
L
G
R
T
G
K
L
F
A
C
E
W
D
G
I
E
P
--
D
V
L
M
L
S
K
S
L
S
G
G
L
I
P
I
G
A
T
L
C
R
A
D
LW
Q
K
A
Y
G
T
A
D
R
F
LVHS
S
-----
T
Y
G
-
G
G
N
L
A
S
V
V
A
L
S
A
L
R
E
I
L
A
Q
D
L
V
G
H
A
E
R
M
G
A
Y
F
K
Q
A
L
S
E
I
A
A
R
Y
P
-
F
V-
S
E
V
R
G
R
G
L
M
L
G
I
-----------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
48.14
33%
-97
- C1 -
4PPM
3
?
A:
[407-740]
--------------
V
D
F
L
K
L
Q
R
C
D
----
N
V
F
R
S
A
A
G
T
Q
L
Y
D
D
A
G
E
A
F
L
D
M
V
A
G
Y
G
C
L
N
L
G
H
-
N
P
Q
P
V
V
N
A
L
K
N
Y
---
L
D
A
Q
-
G
----
P
N
F
I
Q
Y
I
S
I
P
E
Q
T
A
K
L
A
E
V
L
---
C
R
L
A
P
---
G
---
N
M
G
-
R
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
A
---------
S
T
G
K
-
P
G
-
I
A
Y
L
R
N
S
Y
H
G
K
T
L
G
A
L
S
I
T
G
R
D
K
-
H
------
R
-------------------------
R
YFTPL
L
D
----
A
M
V
-------
E
V
-------
P
-------
F
G
---------------
D
---------------------
L
A
A
L
R
E
A
L
------
N
-
R
-------
E
D
----
V
G
A
L
M
I
E
P
I
Q
G
E
G
G
V
H
I
P
P
A
G
Y
L
Q
A
V
Q
Q
L
C
R
E
T
G
V
L
L
M
V
D
E
V
Q
T
G
L
G
R
T
G
K
L
F
A
C
E
W
D
G
I
E
P
--
D
V
L
M
L
S
K
S
L
S
G
G
L
I
P
I
G
A
T
L
C
R
A
D
L
W
Q
K
A
Y
G
T
A
D
R
F
LVHS
S
-----
T
Y
G
-
G
G
N
L
A
S
V
V
A
L
S
A
L
R
E
I
L
A
Q
D
L
V
G
H
A
E
R
M
G
A
Y
F
K
Q
A
L
S
E
I
A
A
R
Y
P
-
F
V-
S
E
V
R
G
R
G
L
M
L
G
I
-----------------------------------------------------------------------------------------------------