@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2099: (2016-02-04 )
MQNILISGAASGIGAASARLFHRRGWRVGLLDIDAEALRGLAAQLPGAWHRAVDVSEPDAVGEALAQFCADGRLRLLFNCAGVLRFGRFEEVALEDHARLLAINLHGVLNCCHAAFPFLRATPQAQVLNMGSASGLYGVPEMAVYSASKFAVRGLTEALELEWRRHGIRVADLMPPFVRTPMVAGQAYQPPVLRRLGLRLDAEDIAEAAWRHAHSRRVHRPVGGLFTALYWAGQLSPPWVNRAVMAWLSRG
Atome Classification :
(20 SA)
.........10........20........30.....-------------...40...-----.-------.--...50.----.-----......60.....----...-70.-........80...---..---.--..90.......---.100.......110.......120-.----.-.....130..-.-....140.......150.......160...--..--..170.......180---.---------------------..-------....---------190-----.------.---......--.200.......-..210....-...220.......230.......240.......250
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQ
N
I
L
ISGAASGI
G
A
A
S
A
R
L
F
H
RRG
W
R
V
G
L
L
DI
D
A
E
-------------
A
L
R
G
L
A
A
Q-----L-------P--G
A
W
HRA----V-----DVSE
P
D
A
V
G
E
A
L
A
----
Q
F
C
-A-D-G
R
L
R
L
L
FN
C
A
G
V
L---RF---G--
R
F
E
E
V
A
L
EDH
A
---
R
L
L
A
I
N
L
H
G
V
L
N
C
C
H
A
A
F
P
F
L
RAT-P----Q-A
Q
V
L
NMGSAS-G-LYGV
P
E
M
A
V
YS
A
S
K
F
A
V
R
G
L
T
E
A
L
E
L
E
W
R
R--HG--
I
R
VADLMP
P
F
VRTPM---V---------------------AG-------QAYQ---------
P
-------
P
------
V
---
L
R
R
LGL--RL--
D
A
E
D
I
A
E
-
A
A
W
R
H
A
H
SR-RVHRP
V
G
G
L
F
T
A
L
Y
W
AGQLS
P
P
W
V
N
R
A
V
M
A
W
LSRG
9
PsiBlast_PDB
91.58
32%
-106
- C1 -
2JAP
2
?
A:
[11-240]
----
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
L
A
A
E
G
A
A
V
A
I
A
A
R
R
V
E
-------------
K
L
R
A
L
G
D
E
-----
L
-------
T
--
A
A
G
A
K
V
H
V
L
E
L
-----
D
V
A
D
R
Q
G
V
D
A
A
V
A
----
S
T
V
E
A
-
L
-
G
G
L
D
I
L
V
N
N
A
G
I
M
---
L
L
---
G
--
P
V
E
D
A
D
T
T
D
W
T
---
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
S
------
K
-
G
T
V
V
Q
M
S
S
I
A
-
G
-
R
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
--
R
G
--
V
R
V
V
V
I
E
P
G
T
T
D
T
E
L
RGH
I
---------------------
T
H
-------
T
A
T
K
---------
E
-------
M
------
Y
---
E
Q
R
I
S
Q
IR
K
L
--
Q
A
Q
D
I
A
E
-
A
V
-
R
Y
A
V
T
A
-
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
V
------------------
37
PsiBlast_CBE
91.49
32%
-107
- C1 -
2JAP
2
?
B:
[11-240]
----
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
L
A
A
E
G
A
A
V
A
I
A
A
R
R
V
E
-------------
K
L
R
A
L
G
D
E
-----
L
-------
T
--
A
A
G
A
K
V
H
V
L
E
L
-----
D
V
A
D
R
Q
G
V
D
A
A
V
A
----
S
T
V
E
A
-
L
-
G
G
L
D
I
L
V
N
N
A
G
I
M
---
L
L
---
G
--
P
V
E
D
A
D
T
T
D
W
T
---
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
S
------
K
-
G
T
V
V
Q
M
S
S
I
A
-
G
-
R
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
--
R
G
--
V
R
V
V
V
I
E
P
G
T
T
D
T
E
L
RGH
I
---------------------
T
H
-------
T
A
T
K
---------
E
-------
M
------
Y
---
E
Q
R
I
S
Q
IR
K
L
--
Q
A
Q
D
I
A
E
-
A
V
-
R
Y
A
V
T
A
-
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
V
------------------
35
PsiBlast_CBE
91.09
32%
-108
- C1 -
2JAP
2
?
D:
[11-240]
----
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
L
A
A
E
G
A
A
V
A
I
A
A
R
R
V
E
-------------
K
L
R
A
L
G
D
E
-----
L
-------
T
--
A
A
G
A
K
V
HVLE
L
-----
D
V
A
D
R
Q
G
V
D
A
A
V
A
----
S
T
V
E
A
-
L
-
G
G
L
D
I
L
V
N
N
A
G
I
M
---
L
L
---
G
--
P
V
E
D
A
D
T
T
D
W
T
---
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
S
------
K
-
G
T
V
V
Q
M
S
S
I
A
-
G
-
R
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
--
R
G
--
V
R
V
V
V
I
E
P
G
T
T
D
T
E
L
RGH
I
---------------------
T
H
-------
T
A
T
K
---------
E
-------
M
------
Y
---
E
Q
R
I
S
Q
IR
K
L
--
Q
A
Q
D
I
A
E
-
A
V
-
R
Y
A
V
T
A
-
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
V
------------------
36
PsiBlast_CBE
90.77
32%
-107
- C1 -
2JAP
2
?
C:
[11-240]
----
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
L
A
A
E
G
A
A
V
A
I
A
A
R
R
V
E
-------------
K
L
R
A
L
G
D
E
-----
L
-------
T
--
A
A
G
A
K
V
HVLE
L
-----
D
V
A
D
R
Q
G
V
D
A
A
V
A
----
S
T
V
E
A
-
L
-
G
G
L
D
I
L
V
N
N
A
G
I
M
---
L
L
---
G
--
P
V
E
D
A
D
T
T
D
W
T
---
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
S
------
K
-
G
T
V
V
Q
M
S
S
I
A
-
G
-
R
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
--
R
G
--
V
R
V
V
V
I
E
P
G
T
T
D
T
E
L
RGH
I
---------------------
T
H
-------
T
A
T
K
---------
E
-------
M
------
Y
---
E
Q
R
I
S
Q
IR
K
L
--
Q
A
Q
D
I
A
E
-
A
V
-
R
Y
A
V
T
A
-
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
V
------------------
113
HHSearch
85.94
30%
-107
- C1 -
3WDS
3
?
A:
[12-248]
G
R
K
A
I
V
T
G
G
S
K
G
I
G
A
A
I
A
R
A
L
D
K
A
G
A
T
V
A
I
A
D
L
D
V
M
-------------
A
A
Q
A
V
V
A
G
-----
L
E------
N
--
G
G
F
A
V
E
----
V
-----
D
V
T
K
R
A
S
V
D
A
A
M
Q
----
K
A
I
-
D
A
L
-
G
G
F
D
L
L
C
A
N
A
G
V
S
---
T
M
---
R
--
P
A
V
D
I
T
D
E
E
W
D
---
F
N
F
D
V
N
A
R
G
V
F
L
A
N
Q
I
A
C
R
H
F
L
A
S
N
T
----
K
-
G
V
I
V
N
T
A
S
L
A
-
A
-
K
V
G
A
P
L
L
A
H
Y
S
A
S
K
F
A
V
F
G
W
T
Q
A
L
A
R
E
M
A
P
--
K
N
--
I
R
V
N
C
V
C
P
G
F
V
K
T
A
M
---
Q
---------------------
E
R
-------
E
I
I
W
E
A
E
L
R
GMT
P
E
-------
A
V
R
A
E
Y
V
S
---
L
T
P
L
G
R
--
I
E
--
E
P
E
D
V
A
D
-
V
V
V
F
L
A
S
D
A
-
A
R
F
M
T
G
Q
G
I
N
V
T
G
G
V
R
M
D
-----------------
116
HHSearch
79.55
27%
-107
- C1 -
3N74
-
?
A:
[5-239]
G
K
V
A
L
I
T
G
A
G
S
G
F
G
E
G
M
A
K
R
F
A
K
G
G
A
K
V
V
I
V
D
R
D
K
A
-------------
G
A
E
R
V
A
G
E
-----
I
G------
D
--
A
A
L
A
V
A
----
A
-----
D
I
S
K
E
A
D
V
D
A
A
V
E
----
A
A
L
-
S
K
F
-
G
K
V
D
I
L
V
N
N
A
G
I
G
---
H
K
---
P
Q-
N
A
E
L
V
E
P
E
E
F
D
---
R
I
V
G
V
N
V
R
G
V
Y
L
M
T
S
K
L
I
P
H
F
K
E
N
-
G
A
K
G
Q
E
-
C
V
I
L
N
V
A
S
T
G
-
A
-
G
R
P
R
P
N
L
A
W
Y
N
A
T
K
G
W
V
V
S
V
T
K
A
L
A
I
E
L
A
P
--
A
K
--
I
R
V
V
A
L
N
P
V
-------------------------------------------------------------------------
I
P
M
G
R
--
L
L
--
K
P
D
D
L
A
E
-
A
A
A
F
L
C
S
P
Q
-
A
S
M
I
T
G
V
A
L
D
V
D
G
G
R
S
I
------------------
114
HHSearch
78.80
32%
-107
- C1 -
1HXH
-
3BHD_COMTE
A:
[6-238]
G
K
V
A
L
V
T
G
G
A
S
G
V
G
L
E
V
V
K
L
L
L
G
E
G
A
K
V
A
F
S
D
I
N
E
A
-------------
A
G
Q
Q
L
A
A
E
-----
L
G------
E
--
R
S
M
F
V
R
----
H
-----
D
V
S
S
E
A
D
W
T
L
V
M
A
----
A
V
Q
-
R
R
L
-
G
T
L
N
V
L
V
N
N
A
G
I
L
---
L
P
---
G
--
D
M
E
T
G
R
L
E
D
F
S
---
R
L
L
K
I
N
T
E
S
V
F
I
G
C
Q
Q
G
I
A
A
M
K
E
T
------
G
-
G
S
I
I
N
M
A
S
V
S
-
S
-
W
L
P
I
E
Q
Y
A
G
Y
S
A
S
K
A
A
V
S
A
L
T
R
A
A
A
L
S
C
R
K
Q
G
Y
A
--
I
R
V
N
S
I
H
P
D
G
I
Y
T
P
M
---
M
---------------------
Q
A
-------
S
L
P
K
---------
G
VSK----
E
MVLHDP
K
---
L
N
R
A
G
R
--
A
Y
--
M
P
E
R
I
A
Q
-
L
V
L
F
L
A
S
D
E
-
S
S
V
M
S
G
S
E
L
H
A
D
N
S
I
L
G
M
G
L
---------------
118
HHSearch
78.09
26%
-106
- C1 -
1CYD
2
CBR2_MOUSE
A:
[7-229]
G
L
R
A
L
V
T
G
A
G
K
G
I
G
R
D
T
V
K
A
L
H
A
S
G
A
K
V
V
A
V
T
R
T
N
S
-------------
D
L
V
S
L
A
K
E
-----
C
-------
P
--
G
I
E
P
V
C
----
V
-----
D
L
G
D
W
D
A
T
E
K
A
L
G
----
G
-----
I
-
G
P
V
D
L
L
V
N
N
A
A
L
V
---
I
M
---
Q
--
P
F
L
E
V
T
K
E
A
F
D
---
R
S
F
S
V
N
L
R
S
V
F
Q
V
S
Q
M
V
A
R
D
M
I
N
R
G
V
----
P
-
G
S
I
V
N
V
S
S
M
V
-
A
-
H
V
T
F
P
N
L
I
T
Y
S
S
T
K
G
A
M
T
M
L
T
K
A
M
A
M
E
L
G
P
--
H
K
--
I
R
V
N
S
V
N
P
T
V
V
L
T
D
M
---
G
---------------------
K
K
-------
V
S
A
D
---------
P
-------
E
F
A
R
K
L
K
E
---
R
H
P
L
R
K
--
F
A
--
E
V
E
D
V
V
N
-
S
I
L
F
L
L
S
D
R
-
S
A
S
T
S
G
G
G
I
L
V
D
A
G
Y
L
A
S
-----------------
108
HHSearch
76.66
27%
-106
- C1 -
3TZQ
1
?
B:
[11-239]
N
K
V
A
I
I
T
G
A
C
G
G
I
G
L
E
T
S
R
V
L
A
R
A
G
A
R
V
V
L
A
D
L
P
E
T
-------------
D
L
A
G
A
A
A
S
-----
V
G------
R
--
G
A
V
H
H
V
----
V
-----
D
L
T
N
E
V
S
V
R
A
L
I
D
----
F
T
I
-
D
T
F
-
G
R
L
D
I
V
D
N
N
A
A
H
S
---
D
P
---
A
DM
L
V
T
Q
M
T
V
D
V
W
D
---
D
T
F
T
V
N
A
R
G
T
M
L
M
C
K
Y
A
I
P
R
L
I
S
A
-
G
----
G
-
G
A
I
V
N
I
S
S
A
T
-
A
-
H
A
A
Y
D
M
S
T
A
Y
A
C
T
K
A
A
I
E
T
L
T
R
Y
V
A
T
Q
Y
G
R
--
H
G
--
V
R
C
N
A
I
A
P
G
L
V
R
T
P
R
---
L
---------------------
E
----------
P
Q
---------
P
I
V
-----
D
I
F
A
---
T
---
H
H
L
A
G
R
--
I
G
--
E
P
H
E
I
A
E
-
L
V
C
F
L
A
S
D
R
-
A
A
F
I
T
G
Q
V
I
A
A
D
S
G
L
L
A
H
L
P
G
L
P
Q
I
R
A
S
V
A
E
L
---
120
HHSearch
75.95
28%
-107
- C1 -
3TSC
1
?
A:
[11-265]
G
R
V
A
F
I
T
G
A
A
R
G
Q
G
R
A
H
A
V
R
M
A
A
E
G
A
D
I
I
A
V
D
I
A
G
K
LPSCVP
Y
D
P
A
S
P
D
D
L
S
E
T
V
R
L
-----
V
E
A
A
N---
R
--
R
I
V
A
A
V
----
V
-----
D
T
R
D
F
D
R
L
R
K
V
V
D
----
D
G
V
-
A
A
L
-
G
R
L
D
I
I
V
A
N
A
G
V
A
---
A
P
---
Q
--
A
W
D
D
I
T
P
E
D
F
R
---
D
V
M
D
I
N
V
T
G
T
W
N
T
V
M
A
G
A
P
R
I
I
E
G
G
R
----
G
-
G
S
I
I
L
I
S
S
A
A
-
G
-
M
K
M
Q
P
F
M
I
H
Y
T
A
S
K
H
A
V
T
G
L
A
R
A
F
A
A
E
L
G
K
--
H
S
--
I
R
V
N
S
V
H
P
G
P
V
N
T
P
M
---
G
---------------------
S
G
-------
D
M
V
T
A
V
-------
G
Q
A
M
E
T
N-
P
QLSH--
V
LT-
P
F
L
P
D
W
--
V
A
--
E
P
E
D
I
A
D
-
T
V
C
W
L
A
S
D
E
-
S
R
K
V
T
A
A
Q
I
P
V
D
Q
G
S
T
Q
Y
-----------------
107
HHSearch
75.61
27%
-104
- C1 -
2CFC
2
HCDR_XANP2
A:
[2-236]
S
R
V
A
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
L
D
L
S
A
E
-------------
T
L
E
E
T
A
R
T
HWHAY
A
-------
D
--
K
V
L
R
V
R
----
A
-----
D
V
A
D
E
G
D
V
N
A
A
I
A
----
A
T
M
-
E
Q
F
-
G
A
I
D
V
L
V
N
N
A
G
I
T
---
G
N
SEA
G
--
V
L
H
T
T
P
V
E
Q
F
D
---
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
-
G
----
A
-
G
V
I
V
N
I
A
S
V
A
-
S
-
L
V
A
F
P
G
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
--
S
G
--
I
R
C
N
A
V
C
P
G
M
I
E
T
P
M
---
T
---------------------
Q
W
-------
R
L
D
Q
---------
P
-------
E
L
R
D
Q
V
L
A
---
R
I
P
Q
K
E
--
I
G
--
T
A
A
Q
V
A
D
-
A
V
M
F
L
A
G
E
D
-
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
A
I
-----------------
10
PsiBlast_PDB
75.61
29%
-118
- C1 -
2CFC
2
HCDR_XANP2
A:
[6-219]
----
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
L
D
L
S
A
E
-------------
T
L
E
E
T
A
R
T
-----
H
-------
W
--
H
A
Y
A
D
K
----
V
L
R
V
R
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
------
G
A
I
D
V
L
V
N
N
A
G
I
T
GNS
E
A
---
G
--
V
L
H
T
T
P
V
E
Q
F
D
---
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
-
G
----
A
-
G
V
I
V
N
I
A
S
V
A
-
S
-
L
V
A
F
P
G
R
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
--
S
G
--
I
R
C
N
A
V
C
P
G
M
I
E
T
P
M
---
T
---------------------
Q
W
-------
R
L
D
Q
---------
P
-------
E
------
L
---
R
D
Q
V
L
A
--
R
I
--
P
Q
K
E
I
G
T
-
A
A
Q
V
A
D
A
V
M
-
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
A
I
-----------
8
PsiBlast_PDB
74.39
32%
-89
- C1 -
1HXH
-
3BHD_COMTE
A:
[10-246]
----
L
V
T
G
G
A
S
G
V
G
L
E
V
V
K
L
L
L
G
E
G
A
K
V
A
F
S
D
I
N
E
A
-------------
A
G
Q
Q
L
A
A
E
-----
L
-------
G
ER
S
M
F
V
R
H
----
D
-----
V
S
S
E
A
D
W
T
L
V
M
A
A
----
V
Q
R
-
R
-
L
-
G
T
L
N
V
L
V
N
N
A
G
I
L
---
L
P
---
G
--
D
M
E
T
G
R
L
E
D
F
S
---
R
L
L
K
I
N
T
E
S
V
F
I
G
C
Q
Q
G
I
A
A
M
K
E
T
-
G
------
G
S
I
I
N
M
A
S
V
S
-
S
-
W
L
P
I
E
Q
Y
A
G
Y
S
A
S
K
A
A
V
S
A
L
T
R
A
A
A
L
S
C
R
K
--
Q
G
YA
I
R
V
N
S
I
H
P
D
G
I
Y
T
P
M
---
M
Q
A
S
LPKGVSKEMVLHDPKLNR
A
G
-------
R
A
Y
M
---------
P
-------
E
------
R
---
I
A
Q
L
V
L
--
F
L
A
S
D
E
S
S
V
M
S
-
G
S
E
L
H
A
D
N
S
-
I
L
G
M
G
L
-----------------------------
117
HHSearch
74.37
28%
-107
- C1 -
2D1Y
1
?
A:
[6-231]
G
K
G
V
L
V
T
G
G
A
R
G
I
G
R
A
I
A
Q
A
F
A
R
E
G
A
L
V
A
L
C
D
L
R
P
E
-------------
G
K
E
-
V
A
E
A
-------------
I
--
G
G
A
F
F
Q
----
V
-----
D
L
E
D
E
R
E
R
V
R
F
V
E
----
E
A
A
-
Y
A
L
-
G
R
V
D
V
L
V
N
N
A
A
I
A
---
A
P
---
G
--
S
A
L
T
V
R
L
P
E
W
R
---
R
V
L
E
V
N
L
T
A
P
M
H
L
S
A
L
A
A
R
E
M
R
K
V
-
G
----
G
-
G
A
I
V
N
V
A
S
V
Q
-
G
-
L
F
A
E
Q
E
N
A
A
Y
N
A
S
K
G
G
L
V
N
L
T
R
S
L
A
L
D
L
A
P
--
L
R
--
I
R
V
N
A
V
A
P
G
A
I
A
T
E
A
---
V
---------------------
L
E
-------
A
I
A
-----------R------
R
D
W
E
---
D
---
L
H
A
L
R
R
--
L
G
--
K
P
E
E
V
A
E
-
A
V
L
F
L
A
S
E
K
-
A
S
F
I
T
G
A
I
L
P
V
D
G
G
M
T
A
S
F
----------------
115
HHSearch
73.89
26%
-111
- C1 -
3GAF
-
?
A:
[11-239]
D
A
V
A
I
V
T
G
A
A
A
G
I
G
R
A
I
A
G
T
F
A
K
A
G
A
S
V
V
V
T
D
L
K
S
E
-------------
G
A
E
A
V
A
A
A
-----
I
R
Q
A
G---
G
--
K
A
I
G
L
E
----
C
-----
N
V
T
D
E
Q
H
R
E
A
V
I
K
----
A
A
L
-
D
Q
F
-
G
K
I
T
V
L
V
N
N
A
G
G
G
---
G
P
---
K
--
P
F
-
D
M
P
M
S
D
F
E
---
W
A
F
K
L
N
L
F
S
L
F
R
L
S
Q
L
A
A
P
H
M
Q
K
A
-
G
----
G
-
G
A
I
L
N
I
S
S
M
A
-
G
-
E
N
T
N
V
R
M
A
S
Y
G
S
S
K
A
A
V
N
H
L
T
R
N
I
A
F
D
V
G
P
--
M
G
--
I
R
V
N
A
I
A
P
G
A
I
K
T
D
A
---
L
---------------------
A
T
-------
V
L
T
P
---------
E
I
E
-----
R
------
A
M
L
K
H
T
P
L
G
R
--
L
G
--
E
A
Q
D
I
A
N
-
A
A
L
F
L
C
S
P
A
-
A
A
W
I
S
G
Q
V
L
T
V
S
G
G
G
V
Q
E
-----------------
16
PsiBlast_PDB
73.24
29%
-123
- C1 -
1VL8
2
?
A:
[25-227]
----
L
V
T
G
G
S
R
G
L
G
F
G
I
A
Q
G
L
A
E
A
G
C
S
V
V
V
A
S
R
N
L
E
-------------
E
A
S
E
A
A
Q
K
-----
L
-------
T
--
E
K
Y
G
V
E
----
T
M
A
F
R
C
D
V
S
N
Y
E
E
V
K
K
L
L
E
----
A
V
K
-
E
-
K
F
G
K
L
D
T
V
V
N
A
A
G
I
N
---
R
R
---
H
--
P
A
E
E
F
P
L
D
E
F
R
---
Q
V
I
E
V
N
L
F
G
T
Y
Y
V
C
R
E
A
F
S
L
L
R
E
S
-
D
----
N
-
P
S
I
I
N
I
G
S
L
T
V
E
-
E
V
T
M
P
N
I
S
A
Y
A
A
S
K
G
G
V
A
S
L
T
K
A
L
A
K
E
W
G
R
--
Y
G
--
I
R
V
N
V
I
A
P
G
W
Y
R
T
K
M
---
T
---------------------
E
A
-------
V
F
S
D
---------
P
-------
E
------
K
---
L
D
Y
M
L
K
--
R
I
--
P
L
G
R
T
G
V
-
P
E
D
L
K
G
V
A
V
-
F
L
A
S
E
E
A
K
Y
V
T
G
Q
I
I
F
V
D
G
G
W
T
A
N
-----------
49
PsiBlast_CBE
73.12
31%
-105
- C1 -
4URE
5
?
B:
[6-225]
-
K
T
A
L
V
T
G
A
G
N
G
I
G
R
T
I
A
L
T
Y
A
A
E
G
A
N
V
V
V
S
D
I
S
D
E
-------------
W
G
R
E
T
L
A
L
-----
I
-------
E
--
G
K
G
G
K
A
----
V
FQHA-
D
T
A
H
P
E
D
H
D
E
L
I
A
----
A
A
K
R
A
-
F
-
G
R
L
D
I
A
C
N
N
A
G
I
-----
S
---
G
--
E
F
T
P
T
A
E
T
T
D
A
QWQ
R
V
I
G
I
N
L
S
G
V
F
Y
G
V
R
A
Q
I
R
A
M
L
E
T
-
G
----
G
-
G
A
I
V
N
I
S
S
I
A
-
G
-
Q
I
G
I
E
G
I
T
P
Y
T
A
A
K
H
G
V
V
G
L
T
K
T
V
A
W
E
Y
G
S
--
K
G
--
I
R
I
N
S
V
G
P
A
F
I
N
T
T
L
---
V
---------------------
Q
N
VPLETRR
Q
L
E
Q
---------
M
-------
H
------
A
---
L
R
R
L
G
-------
E
T
E
E
V
A
N
L
V
A
W
L
S
S
D
K
A
-
S
F
V
T
G
S
Y
Y
A
V
D
G
G
Y
L
A
R
------------------
19
PsiBlast_PDB
72.47
33%
-117
- C1 -
4E6P
5
?
A:
[9-188]
-
K
S
A
L
I
T
G
S
A
R
G
I
G
R
A
F
A
E
A
Y
V
R
E
G
A
T
V
A
I
A
D
I
D
I
E
-------------
R
A
R
Q
A
A
A
E
-----
I
G------
P
--
A
A
Y
A
V
Q
----
M
-----
D
V
T
R
Q
D
S
I
D
A
A
I
A
----
A
T
V
-
E
-
H
A
G
G
L
D
I
L
V
N
N
A
A
L
F
---
D
L
---
A
--
P
I
V
E
I
T
R
E
S
Y
E
---
K
L
F
A
I
N
V
A
G
T
L
F
T
L
Q
A
A
A
R
Q
M
I
A
Q
-
G
----
R
G
G
K
I
I
N
M
A
S
Q
A
-
G
-
R
R
G
E
A
L
V
A
I
Y
C
A
T
K
A
A
V
I
S
L
T
Q
S
A
G
L
D
L
I
K
--
H
R
--
I
N
V
N
A
I
A
P
G
V
V
D
G
E
H
---
W
---------------------
D
G
-------
V
D
A
L
---------
F
-------
A
------
R
---
Y
E
N
R
P
R
--
G
E
--
K
K
R
L
V
G
E
-
A
V
P
F
G
R
M
G
T
-
A
E
D
L
T
G
M
A
I
F
L
A
S
A
E
S
D
Y
I
V
S
Q
T
Y
N
V
D
G
G
N
W
M
S
--
15
PsiBlast_PDB
72.24
31%
-103
- C1 -
4URF
8
?
A:
[6-225]
-
K
T
A
L
V
T
G
A
G
N
G
I
G
R
T
I
A
L
T
Y
A
A
E
G
A
N
V
V
V
S
D
I
S
D
E
-------------
W
G
R
E
T
L
A
L
-----
I
-------
E
--
G
K
G
G
K
A
----
V
F
Q
H
A
-
D
T
A
H
P
E
D
H
D
E
L
I
A
----
A
A
K
R
A
-
F
-
G
R
L
D
I
A
C
N
N
A
G
I
-----
S
---
G
--
E
F
T
P
T
A
E
T
T
D
A
Q
W
Q
R
V
I
G
I
N
L
S
G
V
F
Y
G
V
R
A
Q
I
R
A
M
L
E
T
-
G
----
G
-
G
A
I
V
N
I
S
S
I
A
-
G
-
Q
I
G
I
E
G
I
T
P
Y
T
A
A
K
H
G
V
V
G
L
T
K
T
V
A
W
E
Y
G
S
--
K
G
--
I
R
I
N
S
V
G
P
A
F
I
N
T
T
L
---
V
---------------------
Q
N
VP
L
E
T
R
R
Q
L
E
Q
---------
M
-------
H
------
A
---
L
R
R
L
G
-------
E
T
E
E
V
A
N
L
V
A
W
L
S
S
D
K
A
-
S
F
V
T
G
S
Y
Y
A
V
D
G
G
Y
L
A
R
------------------
119
HHSearch
72.10
26%
-116
- C1 -
1SPX
-
?
A:
[6-252]
E
K
V
A
I
I
T
G
S
S
N
G
I
G
R
A
T
A
V
L
F
A
R
E
G
A
K
V
T
I
T
G
R
H
A
E
-------------
R
L
E
E
T
R
Q
Q
-----
I
L
A
A
GVSE
Q
--
N
V
N
S
V
V
----
A
-----
D
V
T
T
D
A
G
Q
D
E
I
L
S
----
T
T
L
-
G
K
F
-
G
K
L
D
I
L
V
N
N
A
G
-----------------
Q
S
I
E
S
Y
D
---
A
T
L
N
L
N
L
R
S
V
I
A
L
T
K
K
A
V
P
H
L
S
S
T
------
K
-
G
E
I
V
N
I
S
S
I
A
-
S
G
L
H
A
T
P
D
F
P
Y
Y
S
I
A
K
A
A
I
D
Q
Y
T
R
N
T
A
I
D
L
I
Q
--
H
G
--
I
R
V
N
S
I
S
P
G
L
V
A
T
G
F
------------------------------------------------
Y
S
T
M
A
T
M
K
------
E
---
C
V
P
A
G
V
--
M
G
--
Q
P
Q
D
I
A
E
-
V
I
A
F
L
A
D
R
K
T
S
S
Y
I
I
G
H
Q
L
V
V
D
G
G
S
S
L
I
-----------------