@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2709: (2016-02-10 )
MSRIFADNAQSIGNTPLVQINRIAPRGVTILAKIEGRNPGYSVKCRIGANMIWDAEASGRLKSGMTLVEPTSGNTGIGLAFVAAARGYKLILTMPASMSLERRKVLKALGAELVLTEPAKGMKGAIQKAEELVAGDPGKYFMPQQFDNPANPAIHEKTTGPEIWNDTEGAVDVLVSGVGTGGTLTGVSRYIKNTRGKPILAVAVEPVTSPVISQTLAGEEVKPAPHKIQGIGAGFVPKNLDLSLVDRVEKIGDDEAKNMALRLMQEEGILCGISSGAAMAAAVRLAEEPNMQGKTIVVILPDSGERYLSSMLFDGLFSEQELTQ
Atome Classification :
(65 SA)
-----------------------------------........-.10........20..-.--.--.-------..----.--30........40........50........60.--.--.-..-..-.70........80........90........100.......110....-------...120---...---....----130.....-..140.......150-.......160.......-170........180.......190......-.200.......210.......220.......230.......240.......250.......260.......270.......280.....-..290.........300.......310..------.....320..-----------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------MS
R
I
FAD
N
-
A
Q
SIGNT
P
L
V
Q
I
NRI-A--P--R-------
G
V
----
T
--
I
L
A
K
I
EGRNP
G
Y
S
V
K
C
R
IGA
N
M
I
WDAEASGRLK--S--
G
-
M
T
-
L
V
-EPTSGNT
G
I
G
L
A
F
V
A
AARG
Y
K
L
I
L
TMPASM
S
L
E
R
R
K
V
L
K
A
LGA
E
L
V
LT-------EPAK
G
M
---
K
G
A
---
I
Q
K
A
----
E
E
L
VAGDP-GKYFMPQQFDNPANP-AIHEKTTGPEIWNDTE
G
-
A
-
V
D
V
L
V
SGVGTG
G
T
L
T
G
V
S
R
Y
I
K
NTRGK
P
-
I
L
A
V
A
VEPVT
S
P
V
I
S
Q
TLAGEEVKPAPH
K
I
QGIGAGFVPKNL
D
L
S
L
V
D
R
V
E
K
IGD
D
E
A
K
N
M
A
L
R
L
M
Q
EE
G
I
L
C
GISSG
A
A
M
A
A
A
V
R
LAE-EPN--MQG
K
T
I
V
V
I
LPDS
G
E
R
Y
L
S
S
M
L
F
D
------
G
LFS
E
Q
ELTQ-----------------------------------------------------------------------------------------------------------------------------------------------
101
Fugue
97.10
71%
-88
- C3 -
1OAS
1
CYSK_SALTY
A:
[1-315]
------------------------------------
S
K
I
Y
E
D
N
-
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-
G
--
N
--
G
-------------
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
--
P
--
G
-
V
E
-
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
----
E
E
I
V
A
S
D
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
-
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
T
D
L
I
T
V
A
V
E
P
T
D
S
P
V
I
A
Q
A
L
A
G
E
E
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
-
D
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
------
D
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.62
70%
-88
- C3 -
1OAS
1
CYSK_SALTY
A:
[1-315]
------------------------------------
S
K
I
Y
E
D
N
-
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-
G
-------------
N
G
----
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
--
P
--
G
-
V
E
-
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
----
E
E
I
V
A
S
D
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
-
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
T
D
L
I
T
V
A
V
E
P
T
D
S
P
V
I
A
Q
A
L
A
G
E
E
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
-
D
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
------
D
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
96.52
69%
-79
- C3 -
1D6S
2
CYSK_SALTY
A:
[1-322]
------------------------------------
S
K
I
Y
E
D
N
-
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-
G
-------------
N
G
----
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
--
P
--
G
-
V
E
-
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
----
E
E
I
V
A
S
D
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
-
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
T
D
L
I
T
V
A
V
E
P
T
D
S
P
V
I
A
Q
A
L
A
G
E
E
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
-
D
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
------
D
L
F
T
E
K
E
L
Q
Q
-----------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
96.43
69%
-80
- C3 -
1D6S
2
CYSK_SALTY
B:
[1-322]
------------------------------------
S
K
I
Y
E
D
N
-
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-
G
-------------
N
G
----
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
--
P
--
G
-
V
E
-
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
----
E
E
I
V
A
S
D
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
-
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
T
D
L
I
T
V
A
V
E
P
T
D
S
P
V
I
A
Q
A
L
A
G
E
E
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
-
D
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
------
D
L
F
T
E
K
E
L
Q
Q
-----------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
96.34
70%
-88
- C3 -
1OAS
1
CYSK_SALTY
B:
[1-315]
------------------------------------
S
K
I
Y
E
D
N
-
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-
G
-------------
N
G
----
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
--
P
--
G
-
V
E
-
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
----
E
E
I
V
A
S
D
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
-
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
T
D
L
I
T
V
A
V
E
P
T
D
S
P
V
I
A
Q
A
L
A
G
E
E
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
-
D
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
------
D
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
95.37
67%
-89
- C3 -
1Y7L
2
CYSK_HAEIN
A:
[3-311]
--------------------------------------
I
Y
A
D
N
-
S
Y
S
I
G
N
T
P
L
V
R
L
K
H
F
-
G
--
H
--
N
-------
G
-----
N
--
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
T
L
T
--
K
--
G
-
K
E
-
I
V
-
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
A
K
A
----
E
E
I
V
A
S
D
P
-
S
R
Y
V
M
L
K
Q
F
E
N
P
A
N
P
-
Q
I
H
R
E
T
T
G
P
E
I
W
K
D
T
D
G
-
K
-
V
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
L
D
F
G
K
Q
-
I
T
S
V
A
V
E
P
V
E
S
P
V
I
S
Q
T
L
A
G
E
E
V
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
K
-
L
P
E
--
F
A
D
K
L
I
V
V
I
L
P
S
A
S
E
R
Y
L
S
T
A
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
95.14
67%
-79
- C3 -
5DBH
2
?
X:
[9-319]
--------------------------------------
I
Y
A
D
N
-
S
Y
S
I
G
N
T
P
L
V
R
L
K
H
F
-
G
--
H
--
N
-------
G
-----
N
--
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
T
L
T
--
K
--
G
-
K
E
-
I
V
-
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
A
K
A
----
E
E
I
V
A
S
D
P
-
S
R
Y
V
M
L
K
Q
F
E
N
P
A
N
P
-
Q
I
H
R
E
T
T
G
P
E
I
W
K
D
T
D
G
-
K
-
V
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
L
D
F
G
K
Q
-
I
T
S
V
A
V
E
P
V
E
S
P
V
I
S
Q
T
L
A
G
E
E
V
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
K
-
L
P
E
--
F
A
D
K
L
I
V
V
I
L
P
S
A
S
E
R
Y
L
S
T
A
L
F
E
------
G
--------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
94.77
67%
-87
- C3 -
4HO1
3
CYSK_HAEIN
X:
[3-311]
--------------------------------------
I
Y
A
D
N
-
S
Y
S
I
G
N
T
P
L
V
R
L
K
H
F
-
G
--
H
--
N
-------
G
-----
N
--
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
T
L
T
--
K
--
G
-
K
E
-
I
V
-
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
A
K
A
----
E
E
I
V
A
S
D
P
-
S
R
Y
V
M
L
K
Q
F
E
N
P
A
N
P
-
Q
I
H
R
E
T
T
G
P
E
I
W
K
D
T
D
G
-
K
-
V
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
L
D
F
G
K
Q
-
I
T
S
V
A
V
E
P
V
E
S
P
V
I
S
Q
T
L
A
G
E
E
V
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
K
-
L
P
E
--
F
A
D
K
L
I
V
V
I
L
P
S
A
S
E
R
Y
L
S
T
A
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
93.96
70%
-85
- C3 -
1FCJ
4
CYSK_SALTY
D:
[1-302]
------------------------------------
S
K
I
Y
E
D
N
-
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-
G
-------------
N
G
----
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
--
P
--
G
-
V
E
-
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
----
E
E
I
V
A
S
D
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
-
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
T
D
L
I
T
V
A
V
E
P
T
D
S
P
V
I
A
Q
A
L
A
G
E
E
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
-
D
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
93.82
67%
-87
- C3 -
1Y7L
2
CYSK_HAEIN
A:
[2-311]
-------------------------------------
A
I
Y
A
D
N
-
S
Y
S
I
G
N
T
P
L
V
R
L
K
H
F
-
G
--
H
----------
N
G
----
N
--
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
T
L
T
--
K
--
G
-
K
E
-
I
V
-
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
A
K
A
----
E
E
I
V
A
S
D
P
S
R
Y
V
-
M
L
K
Q
F
E
N
P
A
N
P
-
Q
I
H
R
E
T
T
G
P
E
I
W
K
D
T
D
G
-
K
-
V
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
L
D
F
G
K
Q
-
I
T
S
V
A
V
E
P
V
E
S
P
V
I
S
Q
T
L
A
G
E
E
V
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
K
-
L
P
E
--
F
A
D
K
L
I
V
V
I
L
P
S
A
S
E
R
Y
L
S
T
A
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
93.74
70%
-83
- C3 -
1FCJ
4
CYSK_SALTY
B:
[1-304]
------------------------------------
S
K
I
Y
E
D
N
-
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-
G
-------------
N
G
----
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
--
P
--
G
-
V
E
-
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
----
E
E
I
V
A
S
D
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
-
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
T
D
L
I
T
V
A
V
E
P
T
D
S
P
V
I
A
Q
A
L
A
G
E
E
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
-
D
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
93.57
70%
-83
- C3 -
1FCJ
4
CYSK_SALTY
A:
[1-302]
------------------------------------
S
K
I
Y
E
D
N
-
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-
G
-------------
N
G
----
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
--
P
--
G
-
V
E
-
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
----
E
E
I
V
A
S
D
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
-
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
T
D
L
I
T
V
A
V
E
P
T
D
S
P
V
I
A
Q
A
L
A
G
E
E
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
-
D
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
93.12
70%
-81
- C3 -
1FCJ
4
CYSK_SALTY
C:
[1-304]
------------------------------------
S
K
I
Y
E
D
N
-
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-
G
-------------
N
G
----
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
--
P
--
G
-
V
E
-
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
----
E
E
I
V
A
S
D
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
-
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
-
Q
-
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
T
D
L
I
T
V
A
V
E
P
T
D
S
P
V
I
A
Q
A
L
A
G
E
E
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
-
D
E
S
--
F
T
N
K
N
I
V
V
I
L
P
S
S
G
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
87.15
56%
-78
- C3 -
4AEC
4
CYSKM_ARATH
B:
[113-427]
---------------------------------------
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
S
I
-
A
--
K
--
G
-------
C
V
A
---
N
--
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
--
P
--
G
-
K
S
V
L
V
-
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
-------
D
P
A
K
G
M
---
T
G
A
---
V
Q
K
A
----
E
E
I
L
K
N
T
P
-
D
A
Y
M
L
-
Q
Q
F
D
N
P
A
N
P
-
K
I
H
Y
E
T
T
G
P
E
I
W
D
D
T
K
G
-
K
-
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
E
K
N
P
K
--
T
Q
V
I
G
V
E
P
T
E
S
D
I
L
S
G
G
------
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
V
A
K
-
R
P
E
--
N
A
G
K
L
I
A
V
V
F
P
S
F
G
E
R
Y
L
S
T
P
L
F
Q
------
S
I
R
E
E
V
E
K
M
Q
-----------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
86.90
54%
-75
- C3 -
4LMA
3
?
A:
[9-324]
-------------------------------------
R
I
A
H
D
V
-
T
E
L
V
G
R
T
P
L
V
Q
L
N
R
I
----
P
--
Q
-------
A
E
GCL
G
R
--
I
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
L
I
N
--
P
--
E
-
T
T
V
L
V
-
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
-------
P
G
S
Q
G
M
---
K
G
A
---
I
L
R
A
----
Q
Q
I
V
D
S
I
P
-
G
A
Y
M
L
-
Q
Q
F
R
N
P
S
N
P
-
E
I
H
R
L
T
T
A
E
E
I
W
Q
D
T
E
G
-
Q
-
V
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
-
S
R
K
P
S
-
F
Q
V
V
A
V
E
P
F
N
S
P
V
I
S
G
G
------
N
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
N
L
C
A
A
I
Q
L
A
Q
-
R
P
E
--
N
E
G
K
L
I
V
V
I
Q
P
S
F
G
E
R
Y
L
S
T
L
M
F
Q
------
N
I
-
E
E
R
E
L
T
------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
86.57
56%
-77
- C3 -
4AEC
3
CYSKM_ARATH
A:
[113-423]
---------------------------------------
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
S
I
-
A
--
K
--
G
-------
C
V
A
---
N
--
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
--
P
--
G
-
K
S
V
L
V
-
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
-------
D
P
A
K
G
M
---
T
G
A
---
V
Q
K
A
----
E
E
I
L
K
N
T
P
-
D
A
Y
M
L
-
Q
Q
F
D
N
P
A
N
P
-
K
I
H
Y
E
T
T
G
P
E
I
W
D
D
T
K
G
-
K
-
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
E
K
N
P
K
--
T
Q
V
I
G
V
E
P
T
E
S
D
I
L
S
G
G
------
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
V
A
K
-
R
P
E
--
N
A
G
K
L
I
A
V
V
F
P
S
F
G
E
R
Y
L
S
T
P
L
F
Q
------
S
I
R
E
E
V
---------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
86.31
57%
-73
- C3 -
1Z7W
2
CYSK1_ARATH
A:
[3-317]
------------------------------------
S
R
I
A
K
D
V
-
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
-
A
E-
G
--
C
-------
V
G
----
R
--
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
--
P
--
G
E
S
V
-
L
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
-------
D
P
A
K
G
M
---
K
G
A
---
I
A
K
A
----
E
E
I
L
A
K
T
P
-
N
G
Y
-
M
L
Q
Q
F
E
N
P
A
N
P
K
I
-
H
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
-
K
-
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
Q
N
-
A
N
-
V
K
L
Y
G
V
E
P
V
E
S
A
I
L
S
G
------
G
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
-
R
P
E
--
N
A
G
K
L
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
V
L
F
D
------
A
T
R
K
E
A
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
85.41
56%
-72
- C3 -
2ISQ
3
CYSK1_ARATH
A:
[1-314]
------------------------------------
S
R
I
A
K
D
V
-
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
-
A
--
E
--
G
-------
C
V
G
---
R
--
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
--
P
--
G
-
E
S
V
L
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
-------
D
P
A
K
G
M
---
K
G
A
---
I
A
K
A
----
E
E
I
L
A
K
T
P
-
N
G
Y
-
M
L
Q
Q
F
E
N
P
A
N
P
-
K
I
H
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
-
K
-
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
Q
N
A
N
V
-
K
L
-
Y
G
V
E
P
V
E
S
A
I
L
S
G
G
------
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
-
R
P
E
--
N
A
G
K
L
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
V
L
F
D
------
A
T
R
K
E
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
84.87
46%
-80
- C3 -
2PQM
2
?
A:
[10-327]
-----------------------------------
R
K
R
I
Y
H
N
I
-
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
-
T
E-
H
--
P
RIKK---
G
T
----
R
--
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
--
P
--
G
-
M
E
-
I
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
-------
E
G
K
K
G
M
---
P
G
A
---
I
E
E
V
----
N
K
M
I
K
E
N
P
-
G
K
Y
F
V
A
N
Q
F
G
N
P
D
N
T
-
A
-
A
H
H
Y
T
A
N
E
I
W
E
D
T
D
G
-
E
-
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
E
K
K
-
K
G
-
I
K
I
I
A
V
E
P
E
E
S
A
V
L
E
G
K
A
K
------
G
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
-
K
P
E
--
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
K
------
I
K
D
E
G
T
K
--------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
84.77
56%
-70
- C3 -
1Z7W
2
CYSK1_ARATH
A:
[3-316]
------------------------------------
S
R
I
A
K
D
V
-
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
-
A
--
E
--
G
-------
C
V
G
---
R
--
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
--
P
--
G
-
E
S
V
L
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
-------
D
P
A
K
G
M
---
K
G
A
---
I
A
K
A
----
E
E
I
L
A
K
T
P
-
N
G
Y
-
M
L
Q
Q
F
E
N
P
A
N
P
-
K
I
H
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
-
K
-
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
Q
N
A
N
V
-
K
L
-
Y
G
V
E
P
V
E
S
A
I
L
S
G
G
------
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
-
R
P
E
--
N
A
G
K
L
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
V
L
F
D
------
A
T
R
K
E
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
84.75
56%
-68
- C3 -
1Z7Y
1
CYSK1_ARATH
A:
[3-316]
------------------------------------
S
R
I
A
K
D
V
-
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
-
A
--
E
--
G
-------
C
V
G
---
R
--
V
A
A
K
L
E
M
M
E
P
C
S
S
V
A
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
--
P
--
G
-
E
S
V
L
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
-------
D
P
A
K
G
M
---
K
G
A
---
I
A
K
A
----
E
E
I
L
A
K
T
P
-
N
G
Y
-
M
L
Q
Q
F
E
N
P
A
N
P
-
K
I
H
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
-
K
-
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
Q
N
A
N
V
-
K
L
-
Y
G
V
E
P
V
E
S
A
I
L
S
G
G
------
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
-
R
P
E
--
N
A
G
K
L
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
V
L
F
D
------
A
T
R
K
E
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
84.71
47%
-73
- C3 -
3VBE
1
?
B:
[30-339]
--------------------------------------------
S
Q
L
I
G
R
T
P
L
V
Y
L
N
K
V
-
T
--
E
G-
C
-------
G
A
----
Y
--
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
--
P
--
G
K
T
T
-
L
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
-------
D
P
A
K
G
M
---
G
G
T
---
V
K
K
A
----
Y
E
L
L
E
N
T
P
-
N
A
H
-
M
L
Q
Q
F
S
N
P
A
N
T
-
Q
V
H
F
E
T
T
G
P
E
I
W
E
D
T
N
G
-
Q
-
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
-
S
K
N
P
N
-
V
K
I
Y
G
V
E
P
S
E
S
N
V
L
N
G
G
------
K
P
G
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
A
Q
-
L
P
E
--
N
K
G
K
L
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
------
E
L
R
Q
E
A
E
N
M
Q
-----------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
84.58
56%
-81
- C3 -
3ZEI
4
CYSK_MYCTU
A:
[3-300]
--------------------------------------
I
A
E
D
I
-
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
-
T
--
D
--
G
-------
A
V
----
A
D
-
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
--
P
--
D
-
T
I
-
I
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
-------
P
G
A
D
G
M
---
S
G
A
---
I
A
K
A
----
E
E
L
A
K
T
D
--
Q
R
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
-
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
-
K
-
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
-
R
K
P
S
-
A
R
F
V
A
V
E
P
A
A
S
P
V
L
S
G
G
Q
K
G
------
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
-
R
P
E
--
N
A
G
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
84.53
54%
-77
- C3 -
4LMA
2
?
B:
[9-319]
-------------------------------------
R
I
A
H
D
V
-
T
E
L
V
G
R
T
P
L
V
Q
L
N
R
I
----
P
--
Q
-------
A
E
GCLG
R
--
I
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
L
I
N
--
P
--
E
-
T
T
V
L
V
-
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
-------
P
G
S
Q
G
M
---
K
G
A
---
I
L
R
A
----
Q
Q
I
V
D
S
I
P
-
G
A
Y
M
L
-
Q
Q
F
R
N
P
S
N
P
-
E
I
H
R
L
T
T
A
E
E
I
W
Q
D
T
E
G
-
Q
-
V
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
-
S
R
K
P
S
-
F
Q
V
V
A
V
E
P
F
N
S
P
V
I
S
G
G
------
N
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
N
L
C
A
A
I
Q
L
A
Q
-
R
P
E
--
N
E
G
K
L
I
V
V
I
Q
P
S
F
G
E
R
Y
L
S
T
L
M
F
Q
------
N
I
-
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
84.48
49%
-75
- C3 -
2ECO
2
?
A:
[6-301]
----------------------------------------------
A
I
G
K
T
P
V
V
R
L
A
K
V
-
V
E-
P
--
D
-------
M
A
----
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
PG
S
--
G
-
Q
V
-
I
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
-------
D
P
E
R
R
M
---
L
A
A
---
R
E
E
A
L
R
L
K
E
E
L
G
A
-------
F
M
P
D
Q
F
K
N
P
A
N
V
-
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
-
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
-
R
I
P
H
-
V
K
V
I
A
V
E
P
A
R
S
N
V
L
S
G
G
K
M
G
Q
------
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
-
E
L
G
---
P
G
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
84.46
47%
-74
- C3 -
3VBE
1
?
C:
[30-339]
--------------------------------------------
S
Q
L
I
G
R
T
P
L
V
Y
L
N
K
V
-
T
--
E
G-
C
-------
G
A
----
Y
--
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
--
P
--
G
K
T
T
-
L
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
-------
D
P
A
K
G
M
---
G
G
T
---
V
K
K
A
----
Y
E
L
L
E
N
T
P
-
N
A
H
-
M
L
Q
Q
F
S
N
P
A
N
T
-
Q
V
H
F
E
T
T
G
P
E
I
W
E
D
T
N
G
-
Q
-
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
-
S
K
N
P
N
-
V
K
I
Y
G
V
E
P
S
E
S
N
V
L
N
G
G
------
K
P
G
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
A
Q
-
L
P
E
--
N
K
G
K
L
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
------
E
L
R
Q
E
A
E
N
M
Q
-----------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
84.42
56%
-73
- C3 -
2Q3D
2
CYSK_MYCTU
A:
[6-308]
--------------------------------------
I
A
E
D
I
-
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
-
T
--
D
--
G
-------
A
V
----
A
D
-
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
--
P
--
D
-
T
I
-
I
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
-------
P
G
A
D
G
M
---
S
G
A
---
I
A
K
A
----
E
E
L
A
K
T
D
--
Q
R
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
-
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
-
K
-
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
-
R
K
P
S
-
A
R
F
V
A
V
E
P
A
A
S
P
V
L
S
G
G
Q
K
G
------
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
-
R
P
E
--
N
A
G
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
S
T
P
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
84.38
49%
-70
* C3 *
1VE1
1
?
A:
[2-302]
-----------------------------------------
R
V
-
E
G
A
I
G
K
T
P
V
V
R
L
A
K
V
-
V
E-
P
--
D
-------
M
A
----
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
--
P
GS
G
-
Q
V
-
I
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
-------
D
P
E
R
R
M
---
L
A
A
---
R
E
E
A
----
L
R
L
K
E
E
L
--
G
A
F
-
M
P
D
Q
F
K
N
P
A
N
V
-
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
-
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
R
I
-
P
H
-
V
K
V
I
A
V
E
P
A
R
S
N
V
L
S
G
G
K
M
------
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
-
E
L
---
G
P
G
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
84.30
49%
-76
- C3 -
1VE1
1
?
A:
[6-301]
----------------------------------------------
A
I
G
K
T
P
V
V
R
L
A
K
V
-
V
E-
P
--
D
-------
M
A
----
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
PG
S
--
G
-
Q
V
-
I
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
-------
D
P
E
R
R
M
---
L
A
A
---
R
E
E
A
L
R
L
K
E
E
L
G
A
-------
F
M
P
D
Q
F
K
N
P
A
N
V
-
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
-
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
-
R
I
P
H
-
V
K
V
I
A
V
E
P
A
R
S
N
V
L
S
G
G
K
M
G
Q
------
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
-
E
L
G
---
P
G
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
84.24
49%
-75
- C3 -
2ECQ
2
?
A:
[6-301]
----------------------------------------------
A
I
G
K
T
P
V
V
R
L
A
K
V
-
V
E-
P
--
D
-------
M
A
----
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
PG
S
--
G
-
Q
V
-
I
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
-------
D
P
E
R
R
M
---
L
A
A
---
R
E
E
A
L
R
L
K
E
E
L
G
A
-------
F
M
P
D
Q
F
K
N
P
A
N
V
-
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
-
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
-
R
I
P
H
-
V
K
V
I
A
V
E
P
A
R
S
N
V
L
S
G
G
K
M
G
Q
------
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
-
E
L
G
---
P
G
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
84.11
49%
-74
- C3 -
2EFY
2
?
B:
[6-301]
----------------------------------------------
A
I
G
K
T
P
V
V
R
L
A
K
V
-
V
E-
P
--
D
-------
M
A
----
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
PG
S
--
G
-
Q
V
-
I
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
-------
D
P
E
R
R
M
---
L
A
A
---
R
E
E
A
LRLK
E
E
L
G
A
-------
F
M
P
D
Q
F
K
N
P
A
N
V
-
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
-
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
-
R
I
P
H
-
V
K
V
I
A
V
E
P
A
R
S
N
V
L
S
G
G
K
M
G
Q
------
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
-
E
L
G
---
P
G
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
84.10
56%
-79
- C3 -
2Q3B
5
CYSK_MYCTU
A:
[4-303]
------------------------------------
M
S
I
A
E
D
I
-
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
-
T
D-
G
--
A
-------
V
A
----
D
--
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
--
P
--
D
-
T
I
-
I
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
-------
P
G
A
D
G
M
---
S
G
A
---
I
A
K
A
----
E
E
L
A
K
T
D
--
Q
R
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
-
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
-
K
-
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
R
K
-
P
S
-
A
R
F
V
A
V
E
P
A
A
S
P
V
L
S
G
G
Q
K
G
------
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
-
R
P
E
--
N
A
G
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
83.87
47%
-76
- C3 -
3VBE
1
?
A:
[30-338]
--------------------------------------------
S
Q
L
I
G
R
T
P
L
V
Y
L
N
K
V
-
T
--
E
G-
C
-------
G
A
----
Y
--
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
--
P
--
G
K
T
T
-
L
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
-------
D
P
A
K
G
M
---
G
G
T
---
V
K
K
A
----
Y
E
L
L
E
N
T
P
-
N
A
H
-
M
L
Q
Q
F
S
N
P
A
N
T
-
Q
V
H
F
E
T
T
G
P
E
I
W
E
D
T
N
G
-
Q
-
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
-
S
K
N
P
N
-
V
K
I
Y
G
V
E
P
S
E
S
N
V
L
N
G
G
------
K
P
G
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
A
Q
-
L
P
E
--
N
K
G
K
L
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
------
E
L
R
Q
E
A
E
N
M
------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
83.36
49%
-78
- C3 -
2EFY
2
?
A:
[6-301]
----------------------------------------------
A
I
G
K
T
P
V
V
R
L
A
K
V
-
V
E-
P
--
D
-------
M
A
----
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
PG
S
--
G
-
Q
V
-
I
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
-------
D
P
E
R
R
M
---
L
A
A
---
R
E
E
A
L
R
L
K
E
E
L
G
A
-------
F
M
P
D
Q
F
K
N
P
A
N
V
-
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
-
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
-
R
I
P
H
-
V
K
V
I
A
V
E
P
A
R
S
N
V
L
S
G
G
K
M
G
Q
------
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
-
E
L
G
---
P
G
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
83.36
46%
-79
- C3 -
2PQM
2
?
A:
[12-319]
-------------------------------------
R
I
Y
H
N
I
-
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
-
T
EH
P
--
R
IKK----
G
T
----
R
--
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
--
P
--
G
-
M
E
-
I
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
-------
E
G
K
K
G
M
---
P
G
A
---
I
E
E
V
----
N
K
M
I
K
E
N
P
-
G
K
Y
F
V
A
N
Q
F
G
N
P
D
N
T
-
A
A
H
H
Y
T
A
N
-
E
I
W
E
D
T
D
G
-
E
-
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
-
K
L
K
E
K
K
K
G
-
I
K
I
I
A
V
E
P
E
E
S
A
V
L
E
G
K
A
K
G
------
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
-
K
P
E
--
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
83.00
46%
-83
- C3 -
2PQM
2
?
B:
[12-319]
-------------------------------------
R
I
Y
H
N
I
-
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
-
T
EH
P
--
R
IKK----
G
T
----
R
--
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
--
P
--
G
-
M
E
-
I
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
-------
E
G
K
K
G
M
---
P
G
A
---
I
E
E
V
----
N
K
M
I
K
E
N
P
-
G
K
Y
F
V
A
N
Q
F
G
N
P
D
N
T
-
A
A
H
H
Y
T
A
N
-
E
I
W
E
D
T
D
G
-
E
-
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
-
K
L
K
E
K
K
K
G
-
I
K
I
I
A
V
E
P
E
E
S
A
V
L
E
G
K
A
K
G
------
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
-
K
P
E
--
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
82.74
53%
-70
- C3 -
4LMB
3
?
A:
[10-317]
--------------------------------------
I
A
R
D
I
-
T
Q
L
V
G
R
T
P
L
V
Q
L
N
R
I
P
V
--
A
--
E
-------
G
V
----
K
A
R
I
V
V
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
L
I
H
--
P
--
D
-
K
T
I
L
V
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
L
T
-------
P
G
S
Q
G
M
---
E
G
A
---
I
T
R
A
----
E
E
I
V
E
N
T
P
-
N
A
Y
S
L
-
Q
Q
F
R
N
P
A
N
P
-
K
I
H
R
E
T
T
A
E
E
I
W
A
D
T
D
G
-
L
-
V
D
I
V
I
G
G
V
G
T
G
G
T
I
T
G
I
A
E
T
I
K
P
R
R
P
Q
--
F
Q
A
I
A
V
E
P
S
N
S
P
V
L
S
G
G
------
Q
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
A
I
F
R
P
E
L
I
D
E
V
I
I
V
D
D
T
E
A
F
A
Y
A
R
R
L
A
R
Q
E
G
L
L
S
G
I
S
A
G
A
A
L
W
A
A
I
Q
V
G
K
-
R
P
E
--
N
E
D
K
L
I
V
M
I
Q
P
S
F
G
E
R
Y
L
S
T
A
L
F
K
------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
82.53
47%
-75
- C3 -
3VBE
1
?
D:
[30-338]
--------------------------------------------
S
Q
L
I
G
R
T
P
L
V
Y
L
N
K
V
-
T
--
E
G-
C
-------
G
A
----
Y
--
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
--
P
--
G
K
T
T
-
L
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
-------
D
P
A
K
G
M
---
G
G
T
---
V
K
K
A
----
Y
E
L
L
E
N
T
P
-
N
A
H
-
M
L
Q
Q
F
S
N
P
A
N
T
-
Q
V
H
F
E
T
T
G
P
E
I
W
E
D
T
N
G
-
Q
-
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
-
S
K
N
P
N
-
V
K
I
Y
G
V
E
P
S
E
S
N
V
L
N
G
G
------
K
P
G
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
A
Q
-
L
P
E
--
N
K
G
K
L
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
------
E
L
R
Q
E
A
E
N
M
------------------------------------------------------------------------------------------------------------------------------------------------
103
Fugue
82.25
38%
-60
- C3 -
3PC3
2
?
A:
[12-515]
YERPADFIDPGKPSKCKWHLGTAEKSP
H
I
H
R
G
I
AH
R
Q
Q
I
T
P
N
I
-
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
-
P
--
A
--
S
D
GI----
E
C
----
E
--
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
--
P
--
G
-
Y
T
-
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
-------
P
T
E
A
A
Y
DSP
E
G
L
---
I
Y
V
A
----
Q
Q
L
Q
R
E
T
P
-
N
S
I
V
L
D
Q
-
Y
R
N
A
G
N
P
-
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
-
K
-
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
Q
V
-
P
S
-
C
Q
I
V
G
V
D
P
Y
G
S
-
I
L
A
R
P
A
E
L
N
K
T
D
V
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
R
-
K
L
K
---
K
G
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
F
V
S
D
------
N
W
M
E
A
R
N
F
K
E
P
V
NEHGHWWWSLAIAELELPAPP
V
I
L
K
SDAT
V
G
E
A
I
A
L
M
K
K
H
RVD
Q
L
P
V
V
D
QDDGSVL
G
V
V
G
Q
E
T
L
I
T
Q
I
VSMNRQQSDPAIKALNKRV
I
R
L
N
ESEI
L
G
K
L
A
R
V
L
E
V
DP
S
V
L
I
L
G
K
N
PAG
K
V
E
L
K
A
L
A
T
K
L
D
V
T
T
F
I
A
A
GKQK
36
PsiBlast_CBE
81.76
46%
-78
- C3 -
3BM5
4
?
A:
[11-318]
-------------------------------------
R
I
Y
H
N
I
-
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
-
T
EH
P
--
R
IKK----
G
T
----
R
--
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
--
P
--
G
-
M
E
-
I
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
-------
E
G
K
K
G
M
---
P
G
A
---
I
E
E
V
----
N
K
M
I
K
E
N
P
-
G
K
Y
F
V
A
N
Q
F
G
N
P
D
N
T
-
A
A
H
H
Y
T
A
N
-
E
I
W
E
D
T
D
G
-
E
-
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
-
K
L
K
E
K
K
K
G
-
I
K
I
I
A
V
E
P
E
E
S
A
V
L
E
G
K
A
K
G
------
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
-
K
P
E
--
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
81.68
48%
-68
- C3 -
3TBH
2
?
A:
[9-319]
------------------------------------
K
N
V
A
Q
S
I
-
D
Q
L
I
G
Q
T
P
A
L
Y
L
N
K
L
-
N
--
N
--
T
-------
K
A
----
K
--
V
V
L
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
--
P
--
G
K
S
I
-
V
V
-
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
-------
P
A
A
L
G
M
---
K
G
A
---
V
A
M
A
----
K
K
I
V
A
A
N
P
-
N
A
V
-
L
A
D
Q
F
A
T
K
Y
N
A
-
L
I
H
E
E
T
T
G
P
E
I
W
E
Q
T
N
H
-
N
-
V
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
K
M
G
-
S
H
-
A
R
I
V
A
V
E
P
T
E
S
P
V
L
S
G
G
------
K
P
G
P
H
K
I
Q
G
I
G
P
G
F
V
P
D
V
L
D
R
S
L
I
D
E
V
L
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
N
V
Y
A
A
L
K
I
A
E
-
R
P
E
--
M
E
G
K
T
I
V
T
V
I
P
S
F
G
E
R
Y
L
S
T
T
L
Y
R
------
S
V
R
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
81.39
46%
-73
- C3 -
3BM5
4
?
B:
[11-318]
-------------------------------------
R
I
Y
H
N
I
-
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
-
T
EH
P
--
R
IKK----
G
T
----
R
--
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
--
P
--
G
-
M
E
-
I
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
-------
E
G
K
K
G
M
---
P
G
A
---
I
E
E
V
----
N
K
M
I
K
E
N
P
-
G
K
Y
F
V
A
N
Q
F
G
N
P
D
N
T
-
A
A
H
H
Y
T
A
N
-
E
I
W
E
D
T
D
G
-
E
-
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
-
K
L
K
E
K
K
K
G
-
I
K
I
I
A
V
E
P
E
E
S
A
V
L
E
G
K
A
K
G
------
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
E
-
K
P
E
--
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
81.27
39%
-63
- C3 -
4COO
9
CBS_HUMAN
A:
[97-429]
-------------------------------------
K
I
L
P
D
I
-
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
-
G
--
K
--
K
F
GL----
K
C
----
E
--
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
--
P
--
G
-
D
T
-
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
PTNARFD
S
P
E
S
H
V
---
G
V
A
---
W
R
L
K
----
N
E
I
----
P
-
N
S
H
I
L
-
D
Q
Y
R
N
A
S
N
P
-
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
-
K
-
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
-
K
C
P
G
-
C
R
I
I
G
V
D
P
E
G
S
-
I
L
A
E
P
E
E
L
N
Q
T
E
Q
T
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
-
E
L
Q
---
E
G
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
R
W
M
L
Q
K
G
F
L
K
E
E
D
L
T
E
-----------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
80.65
39%
-65
- C3 -
4L0D
2
CBS_HUMAN
B:
[75-407]
-------------------------------------
K
I
L
P
D
I
-
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
-
G
--
K
--
K
F
GL----
K
C
----
E
--
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
--
P
--
G
-
D
T
-
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
PTNARFD
S
P
E
S
H
V
---
G
V
A
---
W
R
L
K
----
N
E
I
----
P
-
N
S
H
I
L
-
D
Q
Y
R
N
A
S
N
P
-
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
-
K
-
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
-
K
C
P
G
-
C
R
I
I
G
V
D
P
E
G
S
-
I
L
A
E
P
E
E
L
N
Q
T
E
Q
T
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
-
E
L
Q
---
E
G
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
R
W
M
L
Q
K
G
F
L
K
E
E
D
L
T
E
-----------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
80.40
38%
-67
- C3 -
3PC2
2
?
A:
[58-372]
-----------------------------------------------
I
G
C
T
P
L
V
K
L
N
N
I
P
A
--
S
--
D
-------
G
I
----
E
C
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
--
P
--
G
-
Y
T
-
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
-------
P
T
E
A
A
Y
DSP
E
G
L
---
I
Y
V
A
----
Q
Q
L
Q
R
E
T
P
-
N
S
I
V
L
-
D
Q
Y
R
N
A
G
N
P
-
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
-
K
-
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
-
Q
V
P
S
-
C
Q
I
V
G
V
D
P
Y
G
S
-
I
L
A
R
P
A
E
L
N
K
T
D
V
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
R
-
K
L
K
---
K
G
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
F
V
S
D
------
N
W
M
E
A
R
N
F
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
80.32
38%
-64
- C3 -
3PC4
3
?
A:
[58-372]
-----------------------------------------------
I
G
C
T
P
L
V
K
L
N
N
I
P
A
--
S
--
D
-------
G
I
----
E
C
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
--
P
--
G
-
Y
T
-
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
-------
P
T
E
A
A
Y
DSP
E
G
L
---
I
Y
V
A
----
Q
Q
L
Q
R
E
T
P
-
N
S
I
V
L
-
D
Q
Y
R
N
A
G
N
P
-
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
-
K
-
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
-
Q
V
P
S
-
C
Q
I
V
G
V
D
P
Y
G
S
-
I
L
A
R
P
A
E
L
N
K
T
D
V
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
R
-
K
L
K
---
K
G
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
F
V
S
D
------
N
W
M
E
A
R
N
F
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
80.25
38%
-62
- C3 -
3PC3
2
?
A:
[58-372]
-----------------------------------------------
I
G
C
T
P
L
V
K
L
N
N
I
P
A
--
S
--
D
-------
G
I
----
E
C
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
--
P
--
G
-
Y
T
-
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
-------
P
T
E
A
A
Y
DSP
E
G
L
---
I
Y
V
A
----
Q
Q
L
Q
R
E
T
P
-
N
S
I
V
L
-
D
Q
Y
R
N
A
G
N
P
-
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
-
K
-
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
-
Q
V
P
S
-
C
Q
I
V
G
V
D
P
Y
G
S
-
I
L
A
R
P
A
E
L
N
K
T
D
V
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
R
-
K
L
K
---
K
G
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
F
V
S
D
------
N
W
M
E
A
R
N
F
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
79.74
43%
-66
- C3 -
3X44
1
?
A:
[2-311]
-------------------------------------
P
L
F
N
S
I
-
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
-
A
P-
E
----------
H
T
----
S
--
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
--
P
--
G
-
D
T
-
I
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
-------
P
G
H
L
G
S
---
K
G
G
---
N
L
I
A
----
D
E
L
A
E
K
-
Y
-
G
W
F
-
R
A
R
Q
F
D
N
P
A
N
P
-
S
Y
H
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
R
-
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
V
A
R
-
P
E
-
V
R
V
V
A
L
E
P
S
N
A
A
M
L
A
R
G
------
E
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
E
-
H
A
---
P
E
G
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
T
F
L
F
D
------
G
V
D
E
G
S
D
--------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
79.55
43%
-66
- C3 -
3X44
1
?
A:
[3-306]
--------------------------------------
L
F
N
S
I
-
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
-
A
--
P
--
E
-------
H
T
----
S
--
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
--
P
--
G
-
D
T
-
I
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
-------
P
G
H
L
G
S
---
K
G
G
---
N
L
I
A
----
D
E
L
--
A
E
K
-
Y
G
W
F
R
A
R
Q
F
D
N
P
A
N
P
-
S
Y
H
R
E
T
T
A
S
E
I
L
A
D
F
A
G
-
K
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
V
A
R
P
E
--
V
R
V
V
A
L
E
P
S
N
A
A
M
L
A
R
---
G
E
W
---
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
E
-
H
A
P
---
E
G
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
T
F
L
F
D
------
G
V
-------------------------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
79.35
38%
-60
- C3 -
3PC3
2
?
A:
[49-371]
-------------------------------------
Q
I
T
P
N
I
-
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
-
P
A
-
S
D
G
I
-------
E
C
----
E
--
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
--
P
--
G
-
Y
T
-
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
-------
P
T
E
A
A
Y
---
D
S
P
EG
L
I
Y
V
A
----
Q
Q
L
Q
R
E
T
P
-
N
S
I
-
V
L
D
Q
Y
R
N
A
G
N
P
-
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
-
K
-
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
Q
V
-
P
S
-
C
Q
I
V
G
V
D
P
Y
G
S
I
L
A
R
P
-
A
E
L
N
K
T
D
V
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
R
-
K
L
---
K
K
G
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
F
V
S
D
------
N
W
M
E
A
R
N
F
K
------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
78.38
43%
-64
- C3 -
3X44
1
?
B:
[3-306]
--------------------------------------
L
F
N
S
I
-
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
-
A
--
P
--
E
-------
H
T
----
S
--
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
--
P
--
G
-
D
T
-
I
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
-------
P
G
H
L
G
S
---
K
G
G
---
N
L
I
A
----
D
E
L
--
A
E
K
-
Y
G
W
F
R
A
R
Q
F
D
N
P
A
N
P
-
S
Y
H
R
E
T
T
A
S
E
I
L
A
D
F
A
G
-
K
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
V
A
R
P
E
--
V
R
V
V
A
L
E
P
S
N
A
A
M
L
A
R
---
G
E
W
---
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
E
-
H
A
P
---
E
G
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
T
F
L
F
D
------
G
V
-------------------------------------------------------------------------------------------------------------------------------------------------------
117
HHSearch
75.87
36%
-56
- C3 -
3DWG
1
CYSM_MYCTU
A:
[2-318]
-----------------------------------
H
M
T
R
Y
D
S
L
-
L
Q
A
L
G
N
T
P
L
V
G
L
Q
R
L
-
S
P-
R
--
W
DDGRD
G
P
H
V
----
R
--
L
W
A
K
L
E
D
R
N
P
T
G
S
I
K
D
R
P
A
V
R
M
I
E
Q
A
E
A
D
G
L
L
R
--
P
--
G
-
A
T
-
I
L
-
E
P
T
S
G
N
T
G
I
S
L
A
M
A
A
R
L
K
G
Y
R
L
I
C
V
M
P
E
N
T
S
V
E
R
R
Q
L
L
E
L
Y
G
A
Q
I
I
F
S
-------
A
A
E
G
G
S
---
N
T
A
---
V
A
T
A
----
K
E
L
A
A
T
N
P
-
S
W
V
-
M
L
Y
Q
Y
G
N
P
A
N
T
-
D
S
H
Y
C
G
T
G
P
E
L
L
A
D
L
P
--
E
-
I
T
H
F
V
A
G
L
G
T
T
G
T
L
M
G
T
G
R
F
L
R
E
H
V
-
A
N
-
V
K
I
V
A
A
E
P
R
Y
G
E
G
V
Y
A
L
R
-------------
N
M
D
E
G
F
V
P
E
L
Y
D
P
E
I
L
T
A
R
Y
S
V
G
A
V
D
A
V
R
R
T
R
E
L
V
H
T
E
G
I
F
A
G
I
S
T
G
A
V
L
H
A
A
L
G
V
G
A
-
G
A
L
A
A
G
E
R
A
D
I
A
L
V
V
A
D
A
G
W
K
Y
L
S
T
G
A
Y
A
------
G
S
L
D
D
A
E
T
A
------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
75.73
42%
-67
- C3 -
2BHS
1
CYSM_ECOLI
A:
[6-293]
---------------------------------------------
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
-
G
--
P
D-
N
-------
G
S
----
E
--
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
--
P
--
G
-
D
V
-
L
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
-------
T
K
E
Q
G
M
---
E
G
A
---
R
D
L
A
----
L
E
M
A
N
R
G
E
-
G
K
L
L
--
D
Q
F
N
N
P
D
N
P
-
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
-
R
-
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
E
-
Q
S
K
P
-
V
T
I
V
G
L
Q
P
------------
E
E
G
S
S
I
P
-
G
I
R
R
W
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
K
A
N
P
D
-----
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
----------
G
V
F
G
-----------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
74.56
48%
-77
- C3 -
4AIR
5
?
B:
[38-340]
---------------------------------------------
Q
L
I
G
Q
T
P
A
L
Y
L
N
K
L
-
N
--
N
--
T
-------
K
A
----
K
--
V
V
L
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
--
P
--
G
-
K
S
-
V
V
V
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
-------
P
A
A
L
G
M
---
K
G
A
---
V
T
M
A
----
K
K
I
V
T
A
N
P
-
N
A
-
V
L
A
D
Q
F
A
T
K
Y
N
A
-
L
I
H
E
E
T
T
G
P
E
I
W
E
Q
T
N
H
-
N
-
V
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
K
M
-
G
S
H
-
A
R
I
V
A
V
E
P
M
E
--------------------------------
D
R
S
L
I
D
E
V
F
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
N
V
Y
A
A
L
K
I
A
E
-
R
P
E
--
M
E
G
K
T
I
V
T
I
I
P
S
F
G
E
R
Y
L
S
T
A
L
Y
R
------
S
V
R
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
74.45
42%
-65
- C3 -
2BHS
1
CYSM_ECOLI
B:
[6-292]
---------------------------------------------
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
-
G
--
P
D-
N
-------
G
S
----
E
--
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
--
P
--
G
-
D
V
-
L
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
-------
T
K
E
Q
G
M
---
E
G
A
---
R
D
L
A
----
L
E
M
A
N
R
G
E
-
G
K
L
L
--
D
Q
F
N
N
P
D
N
P
-
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
-
R
-
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
E
-
Q
S
K
P
-
V
T
I
V
G
L
Q
P
------------
E
E
G
S
S
I
P
-
G
I
R
R
W
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
K
A
N
P
D
-----
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
----------
G
V
F
------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
74.30
42%
-64
- C3 -
2BHS
1
CYSM_ECOLI
D:
[6-292]
---------------------------------------------
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
-
G
--
P
D-
N
-------
G
S
----
E
--
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
--
P
--
G
-
D
V
-
L
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
-------
T
K
E
Q
G
M
---
E
G
A
---
R
D
L
A
----
L
E
M
A
N
R
G
E
-
G
K
L
L
--
D
Q
F
N
N
P
D
N
P
-
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
-
R
-
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
E
-
Q
S
K
P
-
V
T
I
V
G
L
Q
P
------------
E
E
G
S
S
I
P
-
G
I
R
R
W
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
K
A
N
P
D
-----
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
----------
G
V
F
------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
74.27
42%
-66
- C3 -
2BHS
1
CYSM_ECOLI
C:
[6-292]
---------------------------------------------
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
-
G
--
P
D-
N
-------
G
S
----
E
--
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
--
P
--
G
-
D
V
-
L
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
-------
T
K
E
Q
G
M
---
E
G
A
---
R
D
L
A
----
L
E
M
A
N
R
G
E
-
G
K
L
L
--
D
Q
F
N
N
P
D
N
P
-
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
-
R
-
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
E
-
Q
S
K
P
-
V
T
I
V
G
L
Q
P
------------
E
E
G
S
S
I
P
-
G
I
R
R
W
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
K
A
N
P
D
-----
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
----------
G
V
F
------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
62.53
67%
10
- C3 -
3IQH
2
CYSK_HAEIN
X:
[3-311]
--------------------------------------
I
Y
A
D
N
-
S
Y
S
I
G
N
T
P
L
V
R
L
K
H
F
-
G
--
H
--
N
-------
G
-----
N
--
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
T
L
T
--
K
--
G
-
K
E
-
I
V
-
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
A
K
A
----
E
E
I
V
A
S
D
P
-
S
R
Y
V
M
L
K
Q
F
E
N
P
A
N
P
-
Q
I
H
R
E
T
T
G
P
E
I
W
K
D
T
D
G
-
K
-
V
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
L
D
F
G
K
Q
-
I
T
S
V
A
V
E
P
V
E
S
P
V
I
S
Q
T
L
A
G
E
E
V
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
K
-
L
P
E
--
F
A
D
K
L
I
V
V
I
L
P
S
A
S
E
R
Y
L
S
T
A
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
59.50
67%
11
- C3 -
3IQI
1
CYSK_HAEIN
X:
[3-311]
--------------------------------------
I
Y
A
D
N
-
S
Y
S
I
G
N
T
P
L
V
R
L
K
H
F
-
G
--
H
--
N
-------
G
-----
N
--
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
T
L
T
--
K
--
G
-
K
E
-
I
V
-
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
A
K
A
----
E
E
I
V
A
S
D
P
-
S
R
Y
V
M
L
K
Q
F
E
N
P
A
N
P
-
Q
I
H
R
E
T
T
G
P
E
I
W
K
D
T
D
G
-
K
-
V
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
L
D
F
G
K
Q
-
I
T
S
V
A
V
E
P
V
E
S
P
V
I
S
Q
T
L
A
G
E
E
V
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
K
-
L
P
E
--
F
A
D
K
L
I
V
V
I
L
P
S
A
S
E
R
Y
L
S
T
A
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
58.86
67%
10
- C3 -
3IQG
1
CYSK_HAEIN
X:
[3-311]
--------------------------------------
I
Y
A
D
N
-
S
Y
S
I
G
N
T
P
L
V
R
L
K
H
F
-
G
--
H
--
N
-------
G
-----
N
--
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
T
L
T
--
K
--
G
-
K
E
-
I
V
-
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
A
K
A
----
E
E
I
V
A
S
D
P
-
S
R
Y
V
M
L
K
Q
F
E
N
P
A
N
P
-
Q
I
H
R
E
T
T
G
P
E
I
W
K
D
T
D
G
-
K
-
V
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
L
D
F
G
K
Q
-
I
T
S
V
A
V
E
P
V
E
S
P
V
I
S
Q
T
L
A
G
E
E
V
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
K
-
L
P
E
--
F
A
D
K
L
I
V
V
I
L
P
S
A
S
E
R
Y
L
S
T
A
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
57.85
67%
14
- C3 -
4ZU6
2
CYSK_HAEIN
X:
[19-327]
--------------------------------------
I
Y
A
D
N
-
S
Y
S
I
G
N
T
P
L
V
R
L
K
H
F
-
G
--
H
--
N
-------
G
-----
N
--
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
T
L
T
--
K
--
G
-
K
E
-
I
V
-
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
-------
E
G
A
K
G
-----
G
A
---
I
A
K
A
----
E
E
I
V
A
S
D
P
-
S
R
Y
V
M
L
K
Q
F
E
N
P
A
N
P
-
Q
I
H
R
E
T
T
G
P
E
I
W
K
D
T
D
G
-
K
-
V
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
L
D
F
G
K
Q
-
I
T
S
V
A
V
E
P
V
E
S
P
V
I
S
Q
T
L
A
G
E
E
V
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
K
-
L
P
E
--
F
A
D
K
L
I
V
V
I
L
P
S
A
S
E
R
Y
L
S
T
A
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
56.75
67%
12
- C3 -
4LI3
2
CYSK_HAEIN
X:
[3-311]
--------------------------------------
I
Y
A
D
N
-
S
Y
S
I
G
N
T
P
L
V
R
L
K
H
F
-
G
--
H
--
N
-------
G
-----
N
--
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
T
L
T
--
K
--
G
-
K
E
-
I
V
-
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
A
K
A
----
E
E
I
V
A
S
D
P
-
S
R
Y
V
M
L
K
Q
F
E
N
P
A
N
P
-
Q
I
H
R
E
T
T
G
P
E
I
W
K
D
T
D
G
-
K
-
V
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
L
D
F
G
K
Q
-
I
T
S
V
A
V
E
P
V
E
S
P
V
I
S
Q
T
L
A
G
E
E
V
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
K
-
L
P
E
--
F
A
D
K
L
I
V
V
I
L
P
S
A
S
E
R
Y
L
S
T
A
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
55.22
67%
12
- C3 -
4NU8
2
CYSK_HAEIN
X:
[9-317]
--------------------------------------
I
Y
A
D
N
-
S
Y
S
I
G
N
T
P
L
V
R
L
K
H
F
-
G
--
H
--
N
-------
G
-----
N
--
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
T
L
T
--
K
--
G
-
K
E
-
I
V
-
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
A
K
A
----
E
E
I
V
A
S
D
P
-
S
R
Y
V
M
L
K
Q
F
E
N
P
A
N
P
-
Q
I
H
R
E
T
T
G
P
E
I
W
K
D
T
D
G
-
K
-
V
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
L
D
F
G
K
Q
-
I
T
S
V
A
V
E
P
V
E
S
P
V
I
S
Q
T
L
A
G
E
E
V
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
K
-
L
P
E
--
F
A
D
K
L
I
V
V
I
L
P
S
A
S
E
R
Y
L
S
T
A
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
54.33
67%
20
- C3 -
4ZU1
2
CYSK_HAEIN
X:
[19-327]
--------------------------------------
I
Y
A
D
N
-
S
Y
S
I
G
N
T
P
L
V
R
L
K
H
F
-
G
--
H
--
N
-------
G
-----
N
--
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
T
L
T
--
K
--
G
-
K
E
-
I
V
-
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
-------
E
G
A
K
G
M
---
K
G
A
---
I
A
K
A
----
E
E
I
V
A
S
D
P
-
S
R
Y
V
M
L
K
Q
F
E
N
P
A
N
P
-
Q
I
H
R
E
T
T
G
P
E
I
W
K
D
T
D
G
-
K
-
V
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
L
D
F
G
K
Q
-
I
T
S
V
A
V
E
P
V
E
S
P
V
I
S
Q
T
L
A
G
E
E
V
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
K
-
L
P
E
--
F
A
D
K
L
I
V
V
I
L
P
S
A
S
E
R
Y
L
S
T
A
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
54.12
67%
12
- C3 -
4ORE
2
CYSK_HAEIN
X:
[20-328]
--------------------------------------
I
Y
A
D
N
-
S
Y
S
I
G
N
T
P
L
V
R
L
K
H
F
-
G
--
H
--
N
-------
G
-----
N
--
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
T
L
T
--
K
--
G
-
K
E
-
I
V
-
D
A
T
-
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
-------
E
-
A
K
G
M
---
K
G
A
---
I
A
K
A
----
E
E
I
V
A
S
D
P
-
S
R
Y
V
M
L
K
Q
F
E
N
P
A
N
P
-
Q
I
H
R
E
T
T
G
P
E
I
W
K
D
T
D
G
-
K
-
V
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
L
D
F
G
K
Q
-
I
T
S
V
A
V
E
P
V
E
S
P
V
I
S
Q
T
L
A
G
E
E
V
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
L
A
K
-
L
P
E
--
F
A
D
K
L
I
V
V
I
L
P
S
A
S
E
R
Y
L
S
T
A
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------