@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3795: (2016-02-20 )
MTTRKLGNSGLEIPALVFGGNVFGWTADESTSFRLLDALLDAGLNCIDTADVYSRWVPGHQGGESETLIGKWLKRTGKRDRMVIASKVGMDMGNGHKGLSAAYIEQALERSLRRLQTDYLDLYQSHTDDPHTDLEETLSTYGELIKKGKVRVIGASNYDARRLLEARQVSARLNLPSYQSLQPEYNLYDRADYETNLEPTVEELGIGVISYYSLASGFLSGKYRNQADTAGRARGEKVKGYLNERGVAILAALDEVAEQYNANPTQVALAWLIARPTVTAPIASATSLEQLDDLIAATHLKLDEQAIHRLDSASAY
Atome Classification :
(21 SA)
-.........10........20..-..-.....30........40........50........60........70...---..-.-.-.80.......-.90-...------....------.100.......110.......120....----------------...-130-----------------.......140.......150.......160.......170.......180.......190.......200.......210.......220...-------....230..-.-------.-------....240------.....---...250.......260.......270.......280.......290.......300.........310.---...---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MT
T
R
KLGNSGLE
I
P
A
L
V
FGG-
N
V
-
F
G
-
W
TADES
T
S
F
R
L
L
D
A
L
L
D
AGLNCI
D
T
A
D
V
Y
S
RWVPGHQGGES
E
T
L
I
G
K
W
L
K
---RT-G-K-RD
R
M
V
I
A
S
KV-GMD-MGN------GHKG------
L
S
A
A
Y
I
E
Q
A
L
E
R
S
L
R
R
L
Q
T
D
Y
L
D
L
Y
Q
SH----------------TDD-PHT-----------------
D
L
E
E
T
L
S
T
Y
G
E
L
I
KKG
K
V
R
V
I
GASN
Y
D
A
R
R
L
L
E
A
R
Q
V
S
ARLNLP
S
Y
QSLQPEYNLYDRADYETNLE
P
T
V
E
E
L
G
I
G
V
I
S
Y
Y
S
L
A
S
G
F
LSGKYRN-------QADTAG-RA-R-------
G
-------
E
K
V
K
G
Y
-------
L
N
ER
G
---
V
A
I
L
A
A
L
D
E
V
A
E
Q
YNAN
P
T
Q
V
A
L
A
W
LIARPTVTAPIASAT
S
L
E
Q
L
D
D
L
I
A
A
T
HL--KL
D
E
Q
A
I
H
R
LDSA---SAY---
13
PsiBlast_PDB
95.59
30%
-89
- C7 -
4JTD
1
KCAB2_RAT
A:
[6-319]
----
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
F
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
G
K
A
E
V
V
L
G
N
I
I
K
---
K
K
-
G
W
R
-
R
S
S
L
V
I
T
T
K
I
-
F
W
G
G
K
A
E
------
T
E
R
G
------
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
----------------
R
P
D
-
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
-------
G
I
P
P
Y
S
-
R
A
------------------
S
L
K
G
Y
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
----------
1
PsiBlast_PDB
95.29
32%
-92
- C7 -
1LQA
1
TAS_ECOLI
A:
[1-336]
-
M
Q
Y
H
R
I
P
H
S
S
L
E
V
S
T
L
G
L
G
T
-
M
T
-
F
G
-
E
Q
N
S
E
A
D
A
H
A
Q
L
D
Y
A
V
A
Q
G
I
N
L
I
D
V
A
E
M
Y
P
V
P
P
R
P
E
T
Q
G
L
T
E
T
Y
V
G
N
W
L
A
---
K
H
-
G
-
S
-
R
E
K
L
I
I
A
S
K
V
-
S
G
P
-
S
R
N
------
N
D
K
G
IRPDQA
L
D
R
K
N
I
R
E
A
L
H
D
S
L
K
R
L
Q
T
D
Y
L
D
L
Y
Q
V
H
WPQRPTNCFGKL
G
Y
S
W
T
D
S
A
P
A
V
-----------------
S
L
L
D
T
L
D
A
L
A
E
Y
Q
R
A
G
K
I
R
Y
I
G
V
S
N
E
T
A
F
G
V
M
R
Y
L
H
L
A
D
K
H
D
L
P
R
I
V
T
I
Q
N
P
Y
S
L
L
N
R
S
-
F
E
V
G
L
A
E
V
S
Q
Y
E
G
V
E
L
L
A
Y
S
C
L
G
F
G
T
L
T
G
K
Y
L
N
-------
G
A
K
P
A
G
--
A
-
R
-------
N
T
L
F
----
S
R
F
T
R
Y
-------
S
G
E
Q
T
---
Q
K
A
V
A
A
Y
V
D
I
A
R
R
H
G
L
D
P
A
Q
M
A
L
A
F
V
R
R
Q
P
F
V
A
S
T
L
L
G
A
T
T
M
D
Q
L
K
T
N
I
E
S
L
H
L
--
E
L
S
E
D
V
L
A
E
I
E
A
----------
21
PsiBlast_CBE
95.28
32%
-92
- C7 -
1LQA
1
TAS_ECOLI
B:
[1-336]
-
M
Q
Y
H
R
I
P
H
S
S
L
E
V
S
T
L
G
L
G
T
-
M
T
-
F
G
-
E
Q
N
S
E
A
D
A
H
A
Q
L
D
Y
A
V
A
Q
G
I
N
L
I
D
V
A
E
M
Y
P
V
P
P
R
P
E
T
Q
G
L
T
E
T
Y
V
G
N
W
L
A
---
K
H
-
G
-
S
-
R
E
K
L
I
I
A
S
K
V
-
S
G
P
-
S
R
N
------
N
D
K
G
IRPDQA
L
D
R
K
N
I
R
E
A
L
H
D
S
L
K
R
L
Q
T
D
Y
L
D
L
Y
Q
V
H
WPQRPTNCFGKLGYSW
T
D
S
A
P
A
V
-----------------
S
L
L
D
T
L
D
A
L
A
E
Y
Q
R
A
G
K
I
R
Y
I
G
V
S
N
E
T
A
F
G
V
M
R
Y
L
H
L
A
D
K
H
D
L
P
R
I
V
T
I
Q
N
P
Y
S
L
L
N
R
S
-
F
E
V
G
L
A
E
V
S
Q
Y
E
G
V
E
L
L
A
Y
S
C
L
G
F
G
T
L
T
G
K
Y
L
N
-------
G
A
K
P
A
G
--
A
-
R
-------
N
TLF----
S
R
F
T
R
Y
-------
S
G
E
Q
T
---
Q
K
A
V
A
A
Y
V
D
I
A
R
R
H
G
L
D
P
A
Q
M
A
L
A
F
V
R
R
Q
P
F
V
A
S
T
L
L
G
A
T
T
M
D
Q
L
K
T
N
I
E
S
L
H
L
--
E
L
S
E
D
V
L
A
E
I
E
A
----------
87
HHSearch
95.26
31%
-79
- C7 -
3EAU
3
KCAB2_RAT
A:
[3-321]
-
Q
F
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
-
T
F
G
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
-------
A
A
G
K
A
E
V
V
L
G
N
I
I
K
---
K
K
-
G
-
W
R
R
S
S
L
V
I
T
T
K
I
-
F
W
G
-
G
K
A
E-----
T
E
R
G
------
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
----------------
R
P
D
-
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
-------
G
I
P
P
Y
S
-
R
A
-
S
LKGY
Q
W
L
K
-------
D
K
I
L
S
E
-------
E
G
R
R
Q
---
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
---
L
-----
6
PsiBlast_PDB
95.22
30%
-90
- C7 -
1EXB
1
KCAB2_RAT
A:
[5-318]
----
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
F
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
G
K
A
E
V
V
L
G
N
I
I
K
---
K
K
-
G
W
R
-
R
S
S
L
V
I
T
T
K
I
-
F
W
G
G
K
A
E
------
T
E
R
G
------
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
----------------
R
P
D
-
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
-------
G
I
P
P
Y
S
-
R
A
------------------
S
L
K
G
Y
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
----------
12
PsiBlast_PDB
95.08
30%
-86
- C7 -
4JTC
1
KCAB2_RAT
A:
[6-319]
----
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
F
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
G
K
A
E
V
V
L
G
N
I
I
K
---
K
K
-
G
W
R
-
R
S
S
L
V
I
T
T
K
I
-
F
W
G
G
K
A
E
------
T
E
R
G
------
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
----------------
R
P
D
-
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
-------
G
I
P
P
Y
S
-
R
A
------------------
S
L
K
G
Y
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
----------
4
PsiBlast_PDB
94.92
30%
-90
- C7 -
3EB3
2
KCAB2_RAT
A:
[6-319]
----
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
F
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
G
K
A
E
V
V
L
G
N
I
I
K
---
K
K
-
G
W
R
-
R
S
S
L
V
I
T
T
K
I
F
A
G
G
-
K
A
E
------
T
E
R
G
------
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
----------------
R
P
D
-
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
-------
G
I
P
P
Y
S
-
R
A
------------------
S
L
K
G
Y
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
----------
10
PsiBlast_PDB
94.87
30%
-89
- C7 -
3LNM
1
KCAB2_RAT
A:
[6-319]
----
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
F
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
G
K
A
E
V
V
L
G
N
I
I
K
---
K
K
-
G
W
R
-
R
S
S
L
V
I
T
T
K
I
-
F
W
G
G
K
A
E
------
T
E
R
G
------
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
----------------
R
P
D
-
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
-------
G
I
P
P
Y
S
-
R
A
------------------
S
L
K
G
Y
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
----------
7
PsiBlast_PDB
94.63
30%
-89
- C7 -
1ZSX
4
KCAB2_HUMAN
A:
[27-340]
----
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
F
G
-
G
Q
I
T
D
E
M
A
E
Q
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
G
K
A
E
V
V
L
G
N
I
I
K
---
K
K
-
G
W
R
-
R
S
S
L
V
I
T
T
K
I
-
F
W
G
G
K
A
E
------
T
E
R
G
------
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
----------------
R
P
D
-
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
T
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
-------
G
I
P
P
Y
S
-
R
A
------------------
S
L
K
G
Y
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
D
Q
L
M
E
N
I
G
A
I
Q
V
LP
K
L
S
S
S
I
I
H
E
I
D
S
----------
86
HHSearch
94.53
33%
-86
- C7 -
1LQA
1
TAS_ECOLI
A:
[1-339]
-
M
Q
Y
H
R
I
P
H
S
S
L
E
V
S
T
L
G
L
G
T
-
M
T
-
F
G
-
E
Q
N
S
E
A
D
A
H
A
Q
L
D
Y
A
V
A
Q
G
I
N
L
I
D
V
A
E
M
Y
P
V
P
P
R
P
E
T
Q
G
L
T
E
T
Y
V
G
N
W
L
A
---
K
H
-
G
-
S
-
R
E
K
L
I
I
A
S
K
V
-
S
G
P
-
S
R
N
NDKGIR
P
D
Q
A
------
L
D
R
K
N
I
R
E
A
L
H
D
S
L
K
R
L
Q
T
D
Y
L
D
L
Y
Q
V
H
----------------
W
P
Q
-
R
P
T
NCFGKL
G
Y
S
W
T
DSAPAV
S
L
L
D
T
L
D
A
L
A
E
Y
Q
R
A
G
K
I
R
Y
I
G
V
S
N
E
T
A
F
G
V
M
R
Y
L
H
L
A
D
K
H
D
L
P
R
I
V
T
I
Q
N
P
Y
S
L
L
N
R
S
-
F
E
V
G
L
A
E
V
S
Q
Y
E
G
V
E
L
L
A
Y
S
C
L
G
F
G
T
L
T
G
K
Y
L
N
-------
G
A
K
P
A
G
A
R
N
T
L
-------
F
-------
S
R
F
T
R
Y
-------
S
G
E
Q
T
---
Q
K
A
V
A
A
Y
V
D
I
A
R
R
H
G
L
D
P
A
Q
M
A
L
A
F
V
R
R
Q
P
F
V
A
S
T
L
L
G
A
T
T
M
D
Q
L
K
T
N
I
E
S
L
H
L
--
E
L
S
E
D
V
L
A
E
I
E
A
V
---
H
Q
----
2
PsiBlast_PDB
94.49
30%
-88
- C7 -
3EB4
2
KCAB2_RAT
A:
[6-319]
----
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
F
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
G
K
A
E
V
V
L
G
N
I
I
K
---
K
K
-
G
W
R
-
R
S
S
L
V
I
T
T
K
I
-
F
W
G
G
K
A
E
------
T
E
R
G
------
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
----------------
R
P
D
-
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
R
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
-------
G
I
P
P
Y
S
-
R
A
------------------
S
L
K
G
Y
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
----------
8
PsiBlast_PDB
94.47
30%
-86
- C7 -
2A79
4
KCAB2_RAT
A:
[6-319]
----
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
F
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
G
K
A
E
V
V
L
G
N
I
I
K
---
K
K
-
G
W
R
-
R
S
S
L
V
I
T
T
K
I
-
F
W
G
G
K
A
E
------
T
E
R
G
------
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
----------------
R
P
D
-
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
-------
G
I
P
P
Y
S
-
R
A
------------------
S
L
K
G
Y
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
----------
9
PsiBlast_PDB
94.40
30%
-89
- C7 -
2R9R
1
KCAB2_RAT
A:
[6-319]
----
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
F
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
G
K
A
E
V
V
L
G
N
I
I
K
---
K
K
-
G
W
R
-
R
S
S
L
V
I
T
T
K
I
-
F
W
G
G
K
A
E
------
T
E
R
G
------
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
----------------
R
P
D
-
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
-------
G
I
P
P
Y
S
-
R
A
------------------
S
L
K
G
Y
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
----------
3
PsiBlast_PDB
94.38
30%
-88
- C7 -
3EAU
3
KCAB2_RAT
A:
[6-319]
----
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
F
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
G
K
A
E
V
V
L
G
N
I
I
K
---
K
K
-
G
W
R
-
R
S
S
L
V
I
T
T
K
I
-
F
W
G
G
K
A
E
------
T
E
R
G
------
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
----------------
R
P
D
-
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
-------
G
I
P
P
Y
S
-
R
A
------------------
S
L
K
G
Y
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
----------
92
HHSearch
94.21
31%
-77
- C7 -
3LUT
1
KCAB2_RAT
A:
[37-355]
-
Q
F
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
F
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
-------
A
A
G
K
A
E
V
V
L
G
N
I
I
K
---
K
K
-
G
-
W
R
R
S
S
L
V
I
T
T
K
I
-
F
W
G
-
G
K
A
E-----
T
E
R
G
------
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
----------------
R
P
D
-
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
-------
G
I
P
P
Y
S
-
R
A
-
S
-------
L
KGY
Q
W
L
K
D
K
I
L
S
E
-------
E
G
R
R
Q
---
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
---
L
-----
11
PsiBlast_PDB
94.21
30%
-88
- C7 -
4JTA
1
KCAB2_RAT
A:
[6-319]
----
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
F
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
G
K
A
E
V
V
L
G
N
I
I
K
---
K
K
-
G
W
R
-
R
S
S
L
V
I
T
T
K
I
-
F
W
G
G
K
A
E
------
T
E
R
G
------
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
----------------
R
P
D
-
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
-------
G
I
P
P
Y
S
-
R
A
------------------
S
L
K
G
Y
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
----------
109
Fugue
94.08
30%
-80
- C7 -
1QRQ
1
KCAB2_RAT
A:
[1-325]
L
Q
F
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
-
F
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
G
K
A
E
V
V
L
G
N
I
I
K
---
K
K
G
W
-
R
-
R
S
S
L
V
I
T
T
K
I
F
W
G
G
-
K
A
E
------
T
E
R
G
------
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
----------------
R
P
D
-
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
-------
G
I
P
P
Y
S
-
R
A
-
S
LKGY
Q
W
L
K
-------
D
K
I
L
S
E
-------
E
G
R
R
Q
---
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
---
L
G
N
KPY
14
PsiBlast_PDB
93.96
30%
-86
- C7 -
3LUT
1
KCAB2_RAT
A:
[40-353]
----
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
F
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
G
K
A
E
V
V
L
G
N
I
I
K
---
K
K
-
G
W
R
-
R
S
S
L
V
I
T
T
K
I
-
F
W
G
G
K
A
E
------
T
E
R
G
------
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
----------------
R
P
D
-
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
-------
G
I
P
P
Y
S
-
R
A
------------------
S
L
K
G
Y
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
----------
108
Fugue
93.86
30%
-83
- C7 -
1QRQ
1
KCAB2_RAT
A:
[1-325]
L
Q
F
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
-
F
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
G
K
A
E
V
V
L
G
N
I
I
K
---
K
K
-
G
W
R
-
R
S
S
L
V
I
T
T
K
I
-
F
W
G
G
K
A
E
------
T
E
R
G
------
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
----------------
R
P
D
-
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
P
P
Y
S
R
A
S
L
K
G
Y
-
Q
W
-
L
-------
K
-------
D
K
I
L
S
E
-------
E
G
R
R
Q
---
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
GN
K
P
Y
---
5
PsiBlast_PDB
93.83
30%
-85
- C7 -
1QRQ
1
KCAB2_RAT
A:
[5-318]
----
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
F
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
G
K
A
E
V
V
L
G
N
I
I
K
---
K
K
-
G
W
R
-
R
S
S
L
V
I
T
T
K
I
-
F
W
G
G
K
A
E
------
T
E
R
G
------
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
----------------
R
P
D
-
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
-------
G
I
P
P
Y
S
-
R
A
------------------
S
L
K
G
Y
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
----------
39
PsiBlast_CBE
62.89
32%
-62
- C7 -
1GVE
5
ARK73_RAT
A:
[6-208]
--------------
P
A
T
V
L
G
A
-
M
E
-
M
G
-
R
R
M
D
V
T
S
S
S
A
S
V
R
A
F
L
Q
R
G
H
T
E
I
D
T
A
F
V
Y
A
-------
N
G
Q
S
E
T
I
L
G
D
L
G
L
GLG
R
S
-
G
-
C
-
K
V
K
--
I
A
T
K
A
-
A
P
M
-
F
G
---------
K
T
------
L
K
P
A
D
V
R
F
Q
L
E
T
S
L
K
R
L
Q
C
P
R
V
D
L
F
Y
L
H
----------------
F
P
D
-
H
G
T
-----------------
P
I
E
E
T
L
Q
A
C
H
Q
L
H
Q
E
G
K
F
V
E
L
G
L
S
N
Y
V
S
W
E
V
A
E
I
C
T
L
C
K
K
N
G
W
I
M
P
T
V
Y
Q
G
M
Y
N
A
I
T
R
-
Q
V
E
T
E
L
F
P
C
L
R
H
F
G
L
R
F
Y
A
F
N
P
L
A
G
G
L
L
T
G
R
Y
K
Y
-------
Q
----------------------------------------------------------------------------------------------------------------------------