@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4562: (2016-02-28 )
MNLLKSLAAVSSITMLSRVLGFVRDTILARIFGAGLATDAFFVAFKLPNLLRRIFAEGAFSQAFVPILAEYKNQQGEEATRTFIAYVSGLLTLVLALVTALGILAAPWVIWVTAPGFADTPEKFALTTDLLRVTFPYILLISLSSLAGAILNTWNRFSVPAFVPTLLNVAMIGFALFLTPYFDPPVMVLGWAVLAGGLLQLLYQLPHLRKIGMLVLPRLNLRDSGVWRVMKLMLPAILGVSVSQISLIINTIFASFLAAGSVSWMYYADRLMELPSGVLGVALGTILLPMLAKTYSNKDRHEYSRLLDWGLRLCFLLVLPCSLALAILAEPLTVSLFQYGKFTTVDAAMTQRALVAYSVGLLGIILVKVLAPGFYAQQNIRTPVKIALFTLVSTQLMNLAFIGPLQHAGLALSIGLAACLNAGLLYWQLRKQRLYLPQPGWAKFLVKLVVAVLAMSAVLLATMHWLPAWEQGAMLERFLRLGLLVVAGLLAYFGMLALLGFRLRDFSRRAVL
Atome Classification :
(14 SA)
---------------------------------------------------------------------------------------------------...-......10--------.....---..----.20-.......---..30..---......40...-.-------------------------.-----------...50........------60........70........80.------------.......90--....----------....100....---....110..------.....120......------.130...-----....140---........150.......160------.......-------170.......-------.180....-----.--..190.......200.....-..210----..--..-------...220..-.....230--------------------.......240------------....-----------...250....-...260-----------........270.......280-------........290....-------.----..300....----------...310...-....320--------.........330....--...--------340..----.....350...-....360-.........-370.......380.-.....------.390-.......------.400----...--......410..--------.....420--...---....430...--....440......--.450.-......460------..----......470.........480--------.......490.......500.......510----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------
M
N
L
-
L
K
S
L
A
A
V
S
--------
S
I
T
M
L
---
S
R
----
V
L
--
G
F
V
R
D
T
I
---
L
A
R
I
F
G---AGLAT
D
A
F
F
V
A
-
F
-------------------------
K
-----------
L
P
N
L
L
R
R
I
F
AEGA------
F
S
Q
A
F
V
P
I
L
A
E
Y
KNQQ
G
E
E
A
T
R
T
------------
F
I
A
Y
V
S
G
L
L
--
T
L
V
L
----------
A
L
V
T
A
-
L
G
I
LA---A
P
W
V
I
W
V
TA------PGFADT
P
E
K
F
A
L
T
T
------
D
L
L
R
V
T
F
-----
P
Y
I
L
L
I
----
S
L
S
S
L
A
G
A
I
L
N
TWNRFSV
P
A
F
------
V
P
T
L
L
N
V
-------
A
M
-
I
G
F
A
L
F
L-------TPYFDP
P
V
-----
M
--
V
L
G
W
A
V
L
A
G
G
L
L
Q
L
L
Y
QLP
H
-
L
R
K
I
G
----
M
L
--
V
L-------PRLNLRD
S
-
G
V
W
R
V
M
K
L
--------------------
M
L
P
A
I
LG
V
S
V
------------
S
Q
I
S
-----------
L
I
I
N
T
I
F
A
S
F
-
L
A
AG-S-----------
V
S
W
M
Y
Y
A
D
R
L
M
ELP
S
G
V
L
G
V
--------
A
L
G
T
I
L
L
P
M
L
A
K
TYS-------N----
K
D
R
H
E
Y
S
R
L
----------
L
D
W
G
L
R
L
C
F
-
L
L
V
L
P
----------
C
S
L
A
L
A
I
L
AEPL
T
V
S
L
--
F
QY--------GKFT
T
----
V
D
A
A
M
T
Q
R
A
L
V
-
A
Y
S
V
G
---
L
L
G
I
I
L
V
K
V
-LAPGFYAQQNIRT
P
-
V
K
I
A
L
------
F
T
-
L
-
V
S
T
Q
L
M
N
------
L
A
------
F
IG--PLQHAG
L
A
L
S
I
--------
G
L
A
A
C
L
N
A
--
G
L
L
---
Y
W
Q
L
R
K
Q
RLY--LPQP
G
W
A
K
F
L
V
K
L
--
V
V
A
V
L
-
A
M
S
A
V
L
L
A
-------
T
M
----HWLPAWE--Q
G
A
M
L
E
R
F
L
R
L
G
--------
L
L
V
V
A
G
L
L
A
Y
F
G
M
L
A
L
L
G
F
R
L
R
D
F
SRRAVL----------------------------
15
Fugue
91.23
18%
-116
- C4 -
4GA6
3
AMPPA_THEKO
A:
[1-493]
--------------------------------------------------------------------------M
K
A
K
I
R
I
L
DMFSGRY
T
V
L
I
N
E
E
D
A
K
E
A
K
-
L
H
P
D
D
L
V
K
--------
I
E
A
G
K
---
K
A
----
V
Y
--
G
S
V
A
L
S
N
---
L
V
G
K
G
E
---
V
G
I
S
R
D
V
L
D
L
H
N
F
-------------------------
S
-----------
E
G
E
T
V
S
V
I
P
A
G
T
P
------
E
S
V
R
Y
I
K
K
K
M
H
G
E
K
L
R
K
V
E
I
E
A
I
------------
V
R
D
I
V
D
R
K
L
R
D
I
E
I
S
----------
S
F
V
T
A
-
L
E
I
N
G
---------
L
D
M
------
D
E
I
A
A
L
T
I
A
M
A
E
T
G
------
D
M
L
D
I
D
R
-----
K
P
I
--
M
----
D
V
H
S
I
G
G
----------
V
P
G
N
------
K
T
N
I
L
V
V
-------
P
I
-
V
A
A
A
G
L
T
-------
I
P
K
T
S
S
R
A
-----
I
TS
A
A
G
T
A
D
V
V
E
V
F
A
D
V
S
F
S
L
D
E
-
I
K
R
I
V
----
E
K
--
V
G
-------
A
C
L
V
W
G
G
A
L
N
L
A
P
A
D
D
I
--------------------
T
I
K
A
E
R
A
L
S
I
------------
D
P
T
G
-----------
L
M
L
A
S
I
M
S
K
K
-
Y
A
M
G
-
S
-----------------
Q
Y
V
L
I
D
I
P
T
G
K
-
G
V
--------
K
V
E
T
----------
V
-------
E
----
E
A
R
S
L
A
R
D
F
----------
I
E
L
G
K
R
L
G
Q
-
Y
V
E
V
A
----------
I
T
Y
G
G
Q
P
I
G
H
T
V
G
P
A
L
--
E
A
R
--------
E
A
L
S
A
----
L
M
T
G
K
G
P
G
S
L
I
-
E
K
A
T
G
---
L
A
G
I
L
L
E
M
G
G
V
A
P
A
G
T
G
K
K
M
A
K
E
I
-
L
E
----------------
S
G
K
A
W
------
E
K
------
M
K
E
--
I
I
E
A
Q
G
G
D
P
N
I
--------
K
P
E
E
I
P
I
G
--
D
---------
K
T
Y
T
F
T
--
A
A
T
S
G
Y
V
T
A
I
D
N
R
--
A
I
T
A
I
-
A
R
A
A
G
A
P
E
-------------------
D
--
K
G
A
G
I
E
L
Y
V
K
V
G
--------
E
K
V
K
E
G
D
-
P
L
F
T
I
H
A
E
H
E
A
R
L
D
Q
A
I
V
L
A
R
R
T
EPIRIE---------------------
12
Fugue
77.20
17%
-137
- C6 -
4WRT
2
?
B:
[10-758]
MNINPYF
L
F
I
D
V
PIQAAISTTFPYTGV
P
P
Y
S
H
G
TG
T
G
Y
T
I
D
T
V
I
R
T
H
E
Y
S
NK
G
K
Q
Y
I
S
DVTG
C
T
M
V
D
PTNGPLPEDNEPSAYAQ
L
D
C
V
L
E
A
L
D
R
M
D
E
E
H
P
G
L
-
F
Q
A
A
S
Q
N
A
--------
M
E
T
L
M
V
TT
V
D
----
K
L
--
T
Q
G
R
Q
T
F
D
WT
V
C
R
N
Q
P
---
A
A
T
A
L
N
T
T
I
T
S
-
F
-------------------------
R
L
N
DLNGADKGG
L
I
P
F
C
Q
D
I
I
D
S
L
D
RP
E
M
T
F
F
S
V
K
N
I
K
K
K
L
P
A
K
N
R
K
G
F
L
I
K
R
I
P
M
K
V
K
D
K
I
T
K
V
E
Y
I
K
R
A
L
S
L
N
--
T
M
T
K
D
AERGKL
K
R
R
A
I
A
T
A
G
I
Q
I
R
G
---
F
V
L
V
V
E
N
L
A
------
K
N
I
C
E
N
L
E
Q
S
G
L
P
V
GG
N
E
K
K
A
K
L
S
N
A
V
-----
A
K
M
L
S
N
CPPG
G
I
S
M
T
V
T
G
D
N
T
K
W
N
E
C
L
N
P
R
I
------
F
L
A
M
T
E
R
I
T
R
DSP
I
W
F
-
R
D
F
C
S
I
A
-------
P
V
L
F
S
N
K
I
-----
A
--
R
L
G
K
G
F
M
I
T
S
K
T
K
R
L
K
A
Q
I
P
-
C
P
D
L
F
----
S
I
--
P
L
-------
E
R
Y
N
E
E
T
R
-
A
K
L
K
K
L
K
P
FFNEEG
T
A
S
L
SPGMMMGMF
N
M
L
S
T
V
L
G
V
A
A
------------
L
G
I
K
NIGNKE
Y
L
W
D
G
L
Q
S
S
D
D
F
A
L
F
-
V
N
A
K
-
D
-----------
E
E
T
C
M
E
G
I
N
D
F
Y
R
T
C
K
L
L
G
I
N
M
S
KKK
S
Y
C
N
E
T
G
M
F
E
F
T
S
M
F
Y
R
-------
D
GFVS
N
F
A
M
E
L
P
S
F
GVAGVN
E
S
A
D
M
A
I
G
M
T
I
I
K
-
N
N
M
I
N
----------
N
G
M
G
P
A
T
A
Q
T
A
I
Q
L
F
I
--
A
D
Y
R
Y
T
Y
KCHR
G
D
S
K
V
----
E
G
K
R
M
K
I
I
K
E
L
-
W
E
N
T
K
---
G
R
D
G
L
L
V
A
D
-
G
G
P
N
I
Y
N
L
R
N
L
H
I
P
-
E
I
V
L
K
------
Y
N
-
L
-
M
D
P
E
Y
K
G
------
R
L
L
HPQNP
F
V
G
--
H
L
S
I
E
G
I
K
E
A
D
--------
I
T
K
M
D
Y
D
A
V
S
G
T
H
---
S
W
R
T
K
R
N
R
S
I
--
L
N
T
D
Q
R
N
M
I
L
E
E
Q
--
C
Y
A
K
C
-
C
N
L
F
E
A
C
F
-------
N
S
----
A
S
Y
R
K
P
V
--
G
Q
H
S
M
L
E
A
M
A
H
R
--------
L
R
M
D
A
R
L
D
Y
E
S
G
R
M
S
K
D
D
F
E
K
A
M
A
H
L
G
E
I
-----------------------------
3
HHSearch
76.86
13%
-147
* C10 *
3W4T
9
?
A:
[18-447]
---------------------------------------------------------------------------------------------------
K
A
I
-
V
R
L
S
I
A
M
M
--------
I
G
M
S
V
---
Q
T
----
L
Y
--
N
L
A
D
G
I
W
---
V
S
-
G
L
G
---
P
E
S
L
-
A
A
V
G
L
F
-
F
-------------------------
P
-----------
V
F
M
G
I
I
A
L
A
A
--
G
------
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
------------
V
A
V
H
S
L
I
L
S
--
L
I
L
G
----------
V
T
I
T
I
-
T
M
L
P
A
---
I
D
S
L
F
R
S
M
--------
G
A
K
G
--
E
A
V
E
L
A
I
------
E
Y
A
R
V
L
L
-----
A
G
A
F
I
I
----
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
------
A
M
V
L
G
S
G
-------
L
N
-
I
V
L
D
P
I
F
-------
I
Y
T
L
G
F
G
V
-----
V
--
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
W
L
F
V
K
R
D
----
T
Y
V
D
I
T
L------
R
D
F
S
P
S
R
E
-
I
L
K
D
I
L
R
V
--------------------
G
L
P
S
S
L
S
Q
L
S
------------
M
S
I
A
-----------
M
F
F
L
N
S
V
A
I
T
A
G
G
E
N
-
G
-----------
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
-
V
P
I
L
--------
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
-------
E
----
R
N
V
E
K
L
E
T
A
----------
Y
L
Y
A
I
K
I
A
F
-
M
I
E
L
A
----------
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
--
T
Y
------------------
V
I
K
G
D
L
I
S
A
L
R
-
T
L
P
V
F
---
L
V
L
T
P
F
G
M
M
-
T
S
A
M
F
Q
G
I
G
E
G
E
K
S
-
L
I
L
T
I
------
F
R
T
L
-
V
M
Q
V
G
F
A
------
Y
I
------
F
V
H
Y
T
T
L
G
L
R
G
V
W
I
G
I
--------
V
I
G
N
M
V
A
A
--
I
V
G
---
F
L
W
G
R
M
R
--------------------------------------------------------------------------------------------------------------------------------------
10
Fugue
72.95
14%
-145
- C3 -
5CA8
2
?
A:
[27-687]
--------------------------------------------------------------------------------------DAIQIIDENKHFN
T
G
I
-
L
D
Y
I
N
K
T
S
PADVGNN
Y
H
I
I
S
V
---
F
G
----
S
Q
--
S
T
G
K
S
T
L
---
L
N
R
L
F
N
---
T
N
F
D
V
M
G
I
W
L
A
-
Y
S
P
V
V
S
T
TL
G
H
T
T
S
KS
N
I
L
V
M
D
V
E
GT
D
-----------
E
D
Q
D
F
E
R
K
A
A
L
F
A
------
L
S
T
S
E
V
L
I
I
N
I
W
E
T
Q
V
G
L
Y
Q
G
A
N
-------------
M
G
L
L
K
T
V
F
--
E
V
N
L
----------
S
L
F
G
K
-
S
K
L
E
T
HND
H
K
V
L
L
L
I
V
I
R
DHVGV
T
P
V
E
S
L
A
K
T
F
T
L
D
L
------
Q
N
M
W
S
S
L
-----
A
K
P
A
E
L
----
E
H
L
Q
F
A
D
F
F
D
V
T
F
H
A
L
N
H
K
V
L
------
Q
P
K
E
F
G
E
-------
G
I
-
N
R
L
G
D
R
L
VVSNELF
K
P
E
Y
H
H
D
V
-----
P
--
I
D
G
W
T
M
Y
A
E
R
C
W
E
Q
I
E
T
N
K
D
-
L
D
L
P
T
----
Q
Q
--
I
L
-------
V
A
Q
F
K
C
D
E
-
I
V
E
S
V
F
Q
E
--------------------
F
L
T
K
Y
Q
H
H
F
K
EVDAAPDFEEL
G
A
L
F
A
-----------
D
L
R
Q
D
A
F
E
D
Y
-
D
A
S
A
-
S
RYN
K
A
V
Y
E
Q
K
R
K
K
L
R
W
L
I
N
D
K
L
K
E
V
F
D
V
H
A
K
--------
N
L
C
N
T
L
L
E
K
F
E
K
D
L
V
ALKGKDF
A
----
V
N
V
K
T
L
S
T
K
----------
L
V
E
D
V
N
F
Q
V
S
L
M
S
L
Q
----------
G
D
L
S
L
D
E
I
I
L
A
L
T
K
D
I
D
A
I
V
A
--------
K
Q
Q
V
V
----
E
L
N
S
I
V
N
K
S
V
K
-
K
L
S
A
S
---
L
S
K
S
I
Q
F
E
L
-
G
D
P
N
E
E
T
W
D
N
V
L
Q
Q
-
F
K
G
V
Y
E
KFGGD
F
G
-
L
-
G
T
S
S
T
Q
N
Q
Q
A
I
E
K
F
K
------
F
K
S
--
W
C
Q
F
Y
D
V
T
H
K
L
I
S
R
E
K
L
L
A
L
L
Q
D
R
F
D
D
--
K
F
R
---
Y
D
E
N
G
L
P
K
L
Y
--
L
N
E
Q
D
L
E
K
T
F
A
V
A
--
K
Q
H
A
L
Q
V
L
P
I
L
T
F
A
-------
K
L
ADGS
E
I
V
P
D
Y
D
IF
D
S
K
L
R
E
Q
F
L
D
H
C
--------
F
A
E
I
I
T
E
Q
E
K
L
E
V
L
A
K
F
K
K
E
V
D
A
K
Y
I
E
T
K
R
S
I
V-------------------------
9
Fugue
72.42
15%
-147
- C8 -
3ACP
-
RPN14_YEAST
A:
[1-417]
---------------------------------------------------------------------------------------------------
M
T
---------
K
--------
T
I
T
------------
V
--
A
H
I
Q
Y
D
F
---
K
A
V
L
E
E
---
N
D
E
N
D
D
E
F
Y
I
N
-
V
D
K-----------------------
N
-----------
L
N
E
I
K
E
H
K
I
V
V
L
G
------
N
S
R
---
G
V
D
A
G
K
G
N
T
F
E
K
V
G
S
H
L
------------
Y
K
A
R
L
D
G
-
H
--
D
F
L
F
----------
N
T
I
I
R
-
D
G
S
K
M
---
L
K
R
A
D
Y
T
A
V
------
D
T
A
K
L
Q
M
R
R
F
I
L
G
T
------
T
E
G
D
I
K
V
-----
L
D
S
N
F
N
----
L
Q
R
E
I
D
Q
A
H
V
S
E
I
T
K
L
K
F
F
P
S
------
G
E
A
L
I
S
S
-------
S
---------------------
Q
D
M
-----
Q
--
L
K
I
W
S
V
K
D
G
S
N
P
R
T
L
---------
I
G
----
H
-------------
R
A
T
V
T
D
I
-
A
I
I
D
R
G
R
N
--------------------
V
L
S
A
S
L
D
G
T
I
------------
R
L
W
E
-----------
C
G
T
G
T
T
I
H
T
F
-------------------------
N
R
K
E
N
P
H
D
G
V
N
S
I
--------
A
L
F
V
G
T
D
R
Q
L
H
E
I
S
T
-------
S
----
K
K
N
N
---------------
L
E
F
G
T
Y
G
K
Y
-
V
I
A
G
H
----------
V
S
G
V
I
T
V
H
N
------
V
--
F
S
K
--------
E
Q
T
I
Q
----
L
P
S
K
F
T
C
S
C
N
S
-
L
T
V
D
G
---
N
N
A
N
Y
I
Y
A
G
-
Y
E
N
G
M
L
A
Q
W
D
L
R
S
P
E
C
P
V
G
E
------
F
L
-
I
N
E
G
T
P
I
N
N
------
V
Y
------
F
A
A
--
G
----
A
L
F
V
S
S
--------
G
F
D
T
S
I
K
L
--
D
I
I
---
S
-
D
P
E
S
E
R
P
A
--
I
E
F
E
-----------
T
P
T
F
L
-
V
S
N
D
D
E
V
S
-------
Q
F
----
C
Y
V
S
D
D
E
--
S
N
---------
G
--------
E
V
L
E
V
G
K
N
N
F
C
A
L
Y
N
L
S
N
P
---------------------------------------
11
Fugue
70.54
20%
-85
- C7 -
3WFS
2
?
C:
[23-414]
---------------------------------------------------------------------------------------------------
L
N
F
Y
L
S
Y
F
D
D
V
A
--------
K
V
L
P
R
---
E
H
YCFI
V
G
--
G
W
V
R
D
R
I
---
L
G
E
--
P
---
V
G
Y
N
I
D
V
D
F
L
T
-
T
-------------------------
A
-----------
D
P
V
E
L
A
K
N
F
A
K
R
I
------
G
G
--------------------
H
------------
F
F
V
F
E
P
T
I
A
--
S
V
V
L
----------
H
L
------------
P
P
Y
R
Y
R
F
D
F
------
S
P
L
K
G
K
D
L
E
K
A
L
I
E
------
D
L
K
E
R
D
F
-----
T
A
----------------------------------------
N
A
-------
I
A
-
V
N
L
D
D
V
L
-------
T
I
V
Y
D
P
T
----------
G
G
I
K
D
L
E
Q
G
L
L
R
P
V
----------------------------
S
I
E
N
L
K
R
D
-
P
V
-
R
V
L
R
G
--------------------
F
R
I
A
I
E
K
------------------
N
-----------
L
Q
L
T
E
D
F
Y
E
F
-
V
K
E
D
--------------------------
P
R
I
V
L
K
S
--------
A
V
E
R
I
T
H
E
L
F
K
I
M
K
E
-------
K
----
T
A
H
K
V
I
R
E
L
----------
Y
E
Y
G
V
L
E
A
I
-
I
P
E
I
G
----------
R
L
R
E
V
K
D
P
L
D
E
H
T
L
K
T
--
L
E
Y
--------
L
E
Q
V
I
----
E
D
R
A
K
Y
L
S
A
E
L
-
L
E
N
F
G
KKR
V
L
G
E
F
T
D
V
E
-
L
L
K
W
G
A
L
F
H
D
I
G
K
P
-
Q
T
-
T
F
------
Y
E
-
H
-
D
K
V
G
A
Q
I
------
V
R
------
E
I
G
--
E
R
L
R
W
G
D
E
A
T
E
--------
F
V
A
K
L
V
R
H
--
H
L
R
---
P
F
F
L
R
E
A
F
K
K
GE
L
K
R
R
G
M
A
N
F
W
R
E
C
GD
I
A
P
H
L
-
F
L
L
S
I
A
D
A
-------
M
A
----
S
G
D
E
E
E
D
--
I
K
A
L
M
E
T
I
A
E
L
E
--------
S
F
N
R
N
E
M
K
--------------------------------------------------
13
Fugue
69.16
19%
-128
- C5 -
4RNZ
9
?
A:
[1-369]
-------------------------------------------------------------------------------------------------------------------------------
M
E
----
R
L
--
V
W
D
K
L
T
L
---
L
G
F
L
E
K
---
N
H
I
P
Q
K
L
Y
Y
-----------------------------------------------------
N
------
L
S
S
Q
D
K
E
L
S
A
E
I
Q
S
N
------
V
T
------------
Y
Y
T
L
R
D
A
N
N
--
T
L
I
Q
----------
A
L
I
P
-----
I
S
---
Q
D
L
Q
I
H
I
Y
K
------
K
G
----
E
D
Y
F
L
D
F
I
------
P
I
I
F
T
R
K
-----
E
K
T
L
L
L
----
S
L
Q
T
------------------------------------------------------
S
P
Y
Q
D
I
I
K
-----
A
--
T
N
D
-
P
L
L
A
N
Q
L
M
N
A
Y
K
K
S
V
P
-
F
K
R
L
V
KN
D
K
I
A
--
I
V
-------
Y
T
R
D
Y
R
V
G
-
Q
A
F
G
-------------------------
Q
P
T
I
K
M
A
M
V
------------
S
S
R
S
-----------
N
Q
Y
Y
L
F
S
H
S
--------------------
N
G
H
Y
Y
D
S
K
A
Q
E
V
A
G
-------------------------------------------------------------------
F
-
L
L
E
T
P
----------
V
K
Y
T
-------
R
I
S
S
P
--
F
S
Y
--------
G
R
F
H
R
PHY
G
V
D
Y
A
A
K
H
G
S
L
I
H
S
A
S
D
G
---
R
V
G
F
M
G
V
K
A
-
G
Y
G
K
V
V
E
I
H
L
N
E
L
R
-
L
V
Y
A
H
------
M
S
-
A
-
F
A
N
G
L
K
K
------
G
S
------
F
V
K
--
K
G
Q
I
I
G
R
V
G
S
T
--------
G
---------
P
H
L
---
H
F
G
V
Y
K
N
S
R
P
--
I
N
P
L
G
Y
I
R
----------------------------
T
A
----
K
S
K
L
H
G
K
--
Q
R
E
V
F
L
E
K
A
Q
R
S
--------
K
Q
K
L
E
E
L
L
K
T
H
S
F
E
K
N
S
F
Y
L
L
E
G
F
L
E
H
H
H
H
----------------------------
8
Fugue
64.37
14%
-119
- C8 -
3U9T
-
?
A:
[46-639]
------------------------------------------------------------------------------------------------------------------------
Y
R
S
I
---
Q
R
----
L
L
--
V
A
N
R
G
E
I
---
A
C
R
V
M
R
---
S
A
R
A
L
G
I
G
S
V
A
-
V
-------------------------
H
-----------
S
D
I
D
R
H
A
R
H
V
A
E
A
------
D
I
A
V
D
L
G
---------
G
A
K
P
A
D
S
------------
Y
L
R
-----
G
--
D
R
I
I
----------
A
A
A
L
A
-
S
G
A
Q
A
---
I
H
-----
P
G
------
Y
G
F
L
S
E
N
A
D
F
A
R
A
C
------
E
E
A
G
L
L
F
LGPP
A
A
A
I
D
A
M
----
G
S
K
S
A
A
K
A
L
M
E
E
A
G
V
P
L
V
P
G
Y
H
G
E
A
Q
D
L
E
T
F
R
R
E
-------
A
G
R
I
G
Y
P
V
L
L
-------
K
A
A
A
M
K
V
V
E
R
EAE
L
--
A
E
A
L
S
S
A
Q
R
A
R
M
L
V
E
K
Y
L
L
K
-
P
R
H
V
E
----
I
Q
--
V
F
A
D
RHG
H
C
L
Y
L
N
E
R
D
C
-
S
I
Q
R
R
H
Q
-----------------------
K
V
V
E
E
A
P
A
------------
P
G
L
G
-----------
A
E
L
R
R
A
M
G
E
A
-
A
V
R
A
-
A
-----------
Q
A
I
G
Y
V
G
A
G
T
V
E
F
L
L
D
E
R
G
Q
--------
F
F
F
M
E
M
N
T
R
L
Q
V
E
H
P
-------
V
----
T
E
A
I
T
G
L
D
L
----------
V
A
W
Q
I
R
V
A
R
-
G
E
A
L
P
LTQEQVPL
N
G
H
A
I
E
V
R
L
Y
A
E
D
P
E
G
D
F
--
L
P
A
--------
S
G
R
L
M
----
L
Y
R
E
A
A
A
G
P
G
R
-
R
V
D
S
G
---
V
R
E
G
D
E
V
S
P
-
F
Y
D
P
M
L
A
K
L
I
A
W
G
E
-
T
R
E
E
A
------
R
Q
-
R
-
L
L
A
M
L
A
E
------
T
S
------
V
G
G
--
L
R
T
N
L
A
F
L
R
R
I
--------
L
G
H
P
A
F
A
A
--
A
E
L
DTG
F
I
A
R
H
Q
D
D
L
L
--
P
A
P
Q
A
L
P
E
H
F
W
Q
A
--
A
A
E
A
W
-
L
Q
S
E
P
G
H
R
RDDDPHS
P
W
----
S
R
N
D
G
W
R
--
S
A
L
A
R
E
S
D
L
M
L
R
CRDERRC
V
R
L
R
H
A
S
P
S
Q
Y
R
L
D
G
D
D
L
V
S
R
V
D
G
V
T
R
R
S
A
A
L
R
R
G
R
Q
L
F
L
E
W
EG
E
L
L
A
I
E
A
V
D
PIAEAE
14
Fugue
64.22
19%
-130
* C8 *
2CVH
-
RADB_THEKO
A:
[1-220]
-----------------------------------------------------------------------------------------------------------
M
L
S
T
--------
G
T
K
S
L
---
D
S
----
L
L
G
G
G
F
A
P
G
V
----
L
T
Q
V
Y
G
P
Y
A
S
G
K
T
T
L
A
L
Q
T
G
-
L
-------------------------
L
-----------
S
G
K
K
V
A
Y
V
D
T
E
G
G
------
F
S
P
E
R
L
V
Q
M
A
E
T
R
G
L
N
P
E
E
A
L
S
R
------------
F
I
L
F
T
P
S
D
F
--
K
E
Q
R
----------
R
V
I
G
S
-
L
K
K
T
V
---
D
S
N
F
A
L
V
V
V
------
D
S
I
T
A
H
Y
R
A
E
E
N
R
S
------
G
L
--------------
I
A
----
E
L
S
R
Q
L
Q
V
L
L
W
I
A
R
K
H
N
I
P
V
I
------
V
I
N
Q
V
H
F
-------
D
--------
S
-------
R
T
E
M
T
K
P
V
-----
A
--
E
Q
T
L
G
Y
R
C
K
D
I
L
R
L
-
D
K
L
P
K
--
P
G
L
R
----
V
A
--
V
L
-------
E
R
H
R
F
R
P
E
-
G
L
M
A
Y
F
R
I
--------------------
T
E
R
G
I
E
D
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
59.45
14%
-115
- C10 -
3W4T
8
?
A:
[13-216]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
D
-
P
K
K
A
I
V
R
L
--------------------
S
I
A
M
M
I
G
M
S
V
------------
Q
T
L
Y
-----------
N
L
A
D
G
I
W
V
S
G
-
L
G
P
E
-
S
-----------
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
-
A
L
A
A
--------
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
-------
A
----
R
D
K
E
G
A
D
N
V
----------
A
V
H
S
L
I
L
S
L
-
I
L
G
V
T
----------
I
T
I
T
M
L
P
A
I
D
S
L
F
R
S
---
M
G
A
-----------
K
G
----
E
A
V
E
L
A
I
E
Y
A
R
-
V
L
L
A
G
---
A
F
I
I
V
F
N
N
V
-
G
N
G
I
L
R
G
E
G
D
A
N
R
A
-
M
L
A
M
V
------
L
G
-
S
-
G
L
N
I
V
L
D
------
P
I
------
F
I
Y
TL
G
F
G
V
V
G
A
A
Y
A
T
--------
L
L
S
M
V
V
T
S
--
L
--------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
40.02
39%
89
- C9 -
3C5Y
-
?
A:
[40-84]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
T
V
A
E
P
L
G
H
K
V
--
F
N
Y
--------
G
M
Y
T
A
----
E
D
K
A
----
S
L
T
-
Y
V
M
N
G
---
L
L
A
G
I
L
L
N
S
-
G
A
A
D
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
27.78
37%
70
* C9 *
3MMS
1
?
A:
[36-99]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----
T
I
--
V
S
-------
H
E
V
V
L
V
E
S
-
G
I
G
K
V
M
S
A
--------------------
M
S
V
A
I
L
A
V
H
F
-------------
Q
V
D
-----------
A
L
I
N
T
G
S
A
G
A
-
V
A
E
G
I
A
-----------
V
G
D
V
V
I
A
D
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
21.82
11%
1557
- C2 -
3W5A
-
SARCO_RABIT
C:
[18-26]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
I
L
I
------
W
L
------
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
19.01
38%
2527
- C1 -
3H3G
-
B:
[4-10]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
D
L
R
R
R
F
------------------------------