@TOME V2.3
(Mar 2018)

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3D Common Core:

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Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : ASAH1_HUMAN: (2018-10-03 )
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW

Atome Classification :

(20 SA) ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10-------......---..20........30...-.....40------........-----.50---........60--........70------....-....80--------.......--.---.90.-----.......100..------......110.......120.---......130---------.-......140-----.--........---150-.--........160....--------------...170...---....180...--.---.-.--.-----190.--------------..--------------.----------------.--------------...200-.--..----.--.--.----..210.--..----------------....-220...-....230.......240-----...-......250.......260.......270.------.------------.----------.----------...280.......290---.......300....---------------...310.---......320---------.----.----------.--.--------------------------------------.----------------------------.------------------------------------.-----------------------------.-------------330--------..---..-------.....340..----------------.---.---------------...350.......360-----.-------------.----------.------.--------.---...370.......---380.......390--.....----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome) (Ident) (Tito) (Num) (QMean) (Ligand) (Uniprot) ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPGRSCVALVL-------LAAAVS---CAVAQHAPPWTEDCRKS-TYPPSG-------PTYRGAVP-----WYT---INLDLPPYKR--WHELMLDKAP------VLKV-IVNSL---------KNMINTF--V---PSGK-----IMQVVDEK-LPG------LLGNFPGPFEEEMKGIAAVT---DIPLGEIIS---------F-NIFYELF-------T--ICTSIVAE---D---K--KGHLIHGRNMDFGVF--------------LGWNINNDT---WVITEQLKPL--T---V-N--L-----DF-Q--------------RN--------------N----------------K--------------TVFKA--S--SF----A--G--Y----VGMLTG--FK----------------PGLF-SLTLNE-RFSINGGYLGILEWI-------LGK-KDVMWIGFLTRTVLENSTSYEEAKNLLTKT------K------------I----------L----------APAYFILGGNQSGEGC---VITRDRKESLDVYE---------------LDAKQGR---WYVVQTNY----------D----R----------W--K--------------------------------------H----------------------------P------------------------------------F-----------------------------F-------------L----------DD---RR-------TPAKMCLNRT----------------S---Q---------------ENISFETMYDVLSTK------P-------------V----------L------N--------K---LTVYTTLIDVTKG---QFETYLRDCPD----PCIGW----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39 Fugue 71.9319% -25 * C4 * - 3W3W - IMB3_YEAST A:[3-1077] ALPEEVNRTLLQIVQAFASDNQIRSVAEKALSEEWITENNIEYLLTFLAEQAAFSQDTTVAALSAVLFRKLALKAPITHIRKEVLAQIRSSLLKGFLSERADSIRHKLSDAIAECVQDDLPAWPELLQALIESLKSGNPNFRESSFRILTTVPYLITAVDINSILPIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWSKLGILLPSLLNSLPRFLDDGKDDALASVFESLIELVELAPKLFKDMFDQIIQFTDMVIKNKDLEPPARTTALELLTVFSENAPQMCKSNQNYGQTLVMVTLIMMTEVSIDDDDAAEWIESDDTDDEEEVTYDHARQALDRVALKLGGEYLAAPLFQYLQQMITSTEWRERFAAMMAL-------SSAAEG---CADVL---------------------------------------------IGEIPKILDM--VIPLINDPHP------RVQYGCCNVL---------GQISTDF--S---P--F-----IQRTAHDRILPA------LISKLTSECTSRVQTHAAAA---LVNFSEFAS---------K-DILEPYL-------DSLLTNLLVLL---Q---S--NKLYVQEQALTTIAF--------------IAEAAKNKF---IKYYDTLMPL--L---L-N--V------L-K--------------VN--------------S----------------V--------------LKGKC--M--EC----A--T--L----IGFAVG-----------------------------KE-KFHEHSQELISILVA-------LQN-SD-ALRSYLEQSWSRICRILG--DDFVPLL------P------------I----------V----------IPPLLITAKATQDVGL---I-EEEEAANFQQYP---------------------D---WDVVQV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG----------------K---H---------------IAIHTSVLDDKVS----------------------A----------M------E--------L---LQSYATLL---RG---QFAVYVKEVMEEIALPSLDFYLHDGVRAAGATLIPILLSCLLAAEELVLLWHKASSKLIGGLMSEPMPEITQVYHNSLVNGIKVMGDNCLSEDQLAAFTKGVSANLTDTYERMQDRDEYNEDFTDEDLLDEINKSIAAVLKTTNGHYLKNLENIWPMINTFLLEPILVIFALVVIGDLIQYEQTASMKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAPSTYADVCIPTLDTLVQIVDGSKLEENRSSTENASAAIAKILYAYNSNIPDTYTANWFKTLPTITDKEAASFNYQFLSQVCAQSNISAVVDSVIQALNERSLTVISSVKKLLGFLPSSDAMAIFNRYPADIMEKVHKWF
2 HHSearch 66.5716% 13 - C5 - - 2X1C AAAA_PENCH B:[2-333] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LH---ILCQGTPFEI--GYEHGSAAKA------VIAR-SIDFA---------VDLIRGKTKK---TDEE-----LKQVLSQL-GRV------IEERWPK-YYEEIRGIAKGA---ERDVSEIVM---------L-NTRTEFAYGLKAARD--GATTAYCQ---L------PNGALQGQNWDFFSA--------------------------------TKEN--L---I-R--L-----TI-R--------------QA--------------G----------------L--------------PTIKF--I--TE----A--G--I----IGK-VG--FN----------------SAGV-AVNYNA-LHLQG------------------LR-PTGVPSHIALRIALEST-SPSQAYDRIVEQ------G------------G----------M----------AASAFIMV-GNGHEAF---GLEFSPTSIRKQVL----------------D---AN---GRMVHTNH--------------------------C--L--------------------------------------L----------------------------QHGKNEKELDPL-------------------------P-----------------------------D-------------S----------WN---RH-------QRMEFLLDGF-------------------------------------DGTKQAFAQLWADEDNYPF-S-------------I----------C------RAYEEGKSRG---ATLFNIIYDHARR---EATVRLGRP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6 HHSearch 64.1919% -5 - C5 - - 2BJF CBH_CLOPE A:[2-295] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CTGLALE---T---K--DGLHLFGRNMDIEYS--------------FNQSI-------IFIPRNFKCV--N---K-S--N-----KK-E--------------LT--------------T----------------K--------------YAVLG--M--GT----IFDD--Y----PTFADG--MN----------------EKGL-GCAGLN-FPVY-VSY---SKED-------IEG-KTNIPVYNFLLWVLANFSSVEEVKEALKNA------N------------IVDIPISENIPN----------TTLHWMIS-DITGKSI---VVEQTKEKL-NVFD---------------------N---NIGVLTNS----------P----TFDWHVANLNQY--V--------------------------------------GLRYNQVPEFKLGDQSLTALGQGTGLVGLPGD----------------------------------F-----------------------------T-------------P----------AS---RF-------IRVAFLRDAM----------------I---KNDK------------DSIDLIEFFHILNNVAM----VRG-----------STRTVEE----K------S--------D---LTQYTSCMCLEKG---IYYYNTYE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8 HHSearch 63.1220% -10 - C5 - - 5J9R - ? C:[1-271] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CTRFVYI---G---E--NNQVMTARSMDWKTD--------------VGT------------------N--------L--------WV-F--------------PR--------------GMERSGEAGPNSVKWTSK--------------YGSVI--A--SG----Y--D-------VSTTDG--MN----------------EAGL-AANVLW-LVE--SSY---PD-Y-------DGK-SPGLSIAAWAQYVLDNFATVEEAVRVLEKN------P------------F----------IIVT-------ATLHLSLS-DASGDSA---IVEYIDGKQ-VIHH--------------------GR---QYQVMTNS----------P----T----------F--DEQL-----------------------------------ALNAYWTQIGGTVML--------------P------------------------------------GTN---------------------------R-------------A----------SD---RF-------VRASFYANAI----------------PKSEN---------------PVEAIASVFSVIRNVSVPY--G-------------I----------T------TPDQPNI--S---STRWRTVIDHKRK---LYFFES------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7 HHSearch 62.7420% -8 - C5 - - 5J9R - ? B:[1-271] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CTRFVYI---G---E--NNQVMTARSMDWKTD--------------VGT------------------N--------L--------WV-F--------------PR--------------GMERSGEAGPNSVKWTSK--------------YGSVI--A--SG----Y--D-------VSTTDG--MN----------------EAGL-AANVLW-LVE--SSY---PD-Y-------DGK-SPGLSIAAWAQYVLDNFATVEEAVRVLEKN------P------------F----------IIVT-------ATLHLSLS-DASGDSA---IVEYIDGKQ-VIHH--------------------GR---QYQVMTNS----------P----T----------F--DEQL-----------------------------------ALNAYWTQIGGTVML--------------P------------------------------------GTN---------------------------R-------------A----------SD---RF-------VRASFYANAI----------------PKSEN---------------PVEAIASVFSVIRNVSVPY--G-------------I----------T------TPDQPNI--S---STRWRTVIDHKRK---LYFFES------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36 Fugue 62.2018% 2 - C2 - - 1CJD - CAPSD_BPPRD A:[15-383] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRNQQAMAANL-------QARQI------VLQQSYPVIQQVETQ-TFDPANRSVFDVTPANVGIVK-----GFL---VKVTAAITNN--HATEAVALTDFGPANLVQRV-IYYDP---------DNQRHTE--T---S-GW-----HLHFVNTA-KQGAPFLSSMVTDSPIKYGDVMNVIDAPA---TIAAGATGE---------L-TMYYWVP-------L--AYSE---T---D---L--TGAVLANVPQS--------------------------------------KQ--R---L-K--L-----EF-A---------------N--------------N----------------N--------------TAFAA--V--GA----N--P--L----EAIYQG--------------------AGAA-DCEFEEISYTVYQSYLDQLPVG-------QNG-YILPLIDLSTLYNLENSAQAGLTPNVDFVVQYANLYR------------Y----------L----------STIAVFDNGGSFNAGTDINYLSQRTANFSDTRK---------------LDPKTWA---AQTRRRIA----------T----D----------F--P--------------------------------------K----------------------------G------------------------------------V-----------------------------Y-------------Y----------CD---NR-------DKPIYTLQY-------------------------------------GNVGFVVNPKTVNQN------A-------------R----------L------L--------M---GYEYFTSR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4 HHSearch 60.8320% 11 - C5 - - 3HBC ? A:[2-274] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N--ACTRAVYL---G---P--DRMVVTGRTMDWK----------------I-----------------MSNI-----------------YV-F--------------PRGMQRAGHNKEKTVNW----------------T--------------SKYGS--V--IA----T--G--YD---IGTCDG--MN----------------EKGL-VASLLF-LPES--VY---SLP--------GDT-RPAMGISIWTQYVLDNFATVREAVDEMKKE------TFRIDAPRM--------------------------STLHMAIT-DETGNTA---VIEYLDGKL-SIHE--------------------GK---EYQVMTNS----------P----R----------Y--ELQLAVNDYWKEVGGLQ----------------------ML---------------------------PGT----------------------------------N-----------------------------R-------------S----------SD---RF-------VRASFYIHAI----------------P---QTAD------------AKIAVPSVLSVMRNVSV----PFG-----------I----------NTPH---I--------S---STRWRSVSDQKNK---VYYFES------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16 HHSearch 60.7918% 15 - C5 - - 5GS7 - ? B:[1-289] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATAITYV---S-------KDHYFGRNFDYEIS--------------Y------------------NE-------V-V--T------I-T--------------PR--------------N----------------YKFSFREVGNLDHH-FAIIG--IAAGI----A--D--Y----PLYYDA--IN----------------EKGL-GMAGLN-FSGY-ADY---KKI--------EEG-KENVSPFEFIPWVLGQCSTVDEAKKLLKNL------N------------L----------VNINFSDELPLSPLHWLLA-DKE-QSI---VVESTKEGL-RVFD---------------------N---PVGVLTNN----------P----T----------F--DYQLFNLNNYRVLSTRTPKNNFSDQIELDIYSRGMGGIGL----------------------------PGD----------------------------------L-----------------------------S-------------S----------VS---RF-------VKATFTKLNS----------------VSRSS---------------EYESISQFFHILSSVEQQK--G-------------L----------CDVGDEKY--------E---YTIYSSCCNLEKG---IYYYRTYD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5 HHSearch 60.1415% -29 - C5 - - 2QUY - PAC_LYSSH C:[1-294] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CSSLSIR---T---T--DDKSLFARTMDFTME--------------PDS----KV---IIVPRNYGIRL-L---E-K--E-----NV-V--------------IN--------------N----------------S--------------YAFVG--M--GS----T--DITS----PVLYDG--VN----------------EKGL-MGAMLY-YAT-FATY---ADEP-------KKG-TRGINPVYVISQVLGNCVTVDDVIEKLTSY------T------------LLNEANIILGFA----------PPLHYTFT-DASGESI---VIEPDKTGI-TIHR--------------------K----TIGVMTASPGYEWHQTNLR----A----------Y--I--------------------------------------G----------------------------VTPNPPQDIMMGDLDLTPFGQGAGGLGLPGD------F-----------------------------T-------------P----------SA---RF-------LRVAYWKKYT----------------E---KAKN------------ETEGVTNLFHILSSV------N-------------IPKGVVLTNEGK------T--------D---YTIYTSAMCAQSK---NYYFKLY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9 HHSearch 59.1517% 1 - C5 - - 3PVA - PAC_LYSSH B:[1-296] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CSSLSIR---T---T--DDKSLFARTMDFTME--------------P------------------DSK--------V--I-----IV-PRNYGIRLLEKENVVIN--------------N----------------S--------------YAFVG--M--GS----T--DITS----PVLYDG--VN----------------EKGL-MGAMLY-YAT-FATY---ADEP-------KKG-TTGINPVYVISQVLGNCVTVDDVIEKLTSY------T------------LLNEANIILGFA----------PPLHYTFT-DASGESI---VIEPDKTGI-TIHR---------------------K---TIGVMTNS----------P----G----------YEWH--------------------------------------Q----------------------------TNLRAYIGVTPNPPQDIMMGDLDLTPFGQGAGGLGLPGDF---------------------------T-------------P----------SA---RF-------LRVAYWKKYT----------------EKAKN---------------ETEGVTNLFHILSSVNIPK--G-------------V----------VLTNEGKT--------D---YTIYTSAMCAQSK---NYYFKLYDN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31 Fugue 58.7516% -7 - C3 - - 5LB8 - RECQ5_HUMAN D:[4-444] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PERRVRSTLKKVFGFDSFKTPLQ---ESATMAVVKGNKDVFVC-MPTGAG-------KSLCYQLP-----ALLAKGITIVVSPLIA--LIQDQVDHLL------TLKV-RVSSLNSKLSAQERKELLADL--EREKPQTK-----ILYITPEM-AA------------SSSFQPTLNSLVS---------RHLLS---------Y-LVVDEAH-------C--V----------S---Q--WGHDFRPDYLRLGAL--------------RSRLGHAPC---VALTATAT----------------------P--------------QV--------------Q----------------E--------------DVFAA--L--HL----K--K--P----VAIFKTPCFR----------------ANLFYDVQFKE-L--ISDPYGNLKDFC-------LKA-CGIVYC--------RTREACEQLAIELSCR------G------------V----------N----------AKAYHA-GLKASERTL---VQNDWMEEKVPVIV---------------ATISFDKANVRFVAHWNI----------A----K----------S--M--------------------------------------A----------------------------G------------------------------------Y-----------------------------Y-------------Q----------ES---GRAGRDGKPSWCRLYYSRN----------------D---R---------------DQVSFLIRKEVAKLQ------EKRGNKASDKATIMA----------F------D--------A---LVTFCEELGCRHA---AIAKYFGDALP----ACAKGCDHCQNPTAVRRRLEALERSSS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40 Fugue 58.4513% -22 - C4 - - 5HTX XK1_ARATH A:[14-437] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKLYLGMDF-------GTSGGR---FTVIDEQGEIKAQGKRE-YPPFMK-------EESMGWASSWKATLFS---LLEDIPVTVRSLVSSISLDGTS------ATTL-ILNS-----------------------ESGE-----VLCQ------PY------LYNQSCPDALPEVKSIAP-------ANHTVCS---------GTSTLCKLV-------S--WWNTEVPN---R---E--SAVLLHQADWLLWLLHGRLGVSDYNNALKVGYDPESESYPSWLLGQPYSQL--L---P-K--VQAPGTSI-G--------------NL--------------K----------------E--------------SFTRQ--F--GF----P--D--D----CIVCTG--TT----------------DSIA-AFLA------ARATEPGKAVTS-------LGS-T--LAIKLLSTKRVDD-------ARYGVYS------H------------R----------L----------DDKWLVGGASNTGGAI---LRQLFSDEQLERLSQEINPMVGSPLDYYPLQSSGER---FPIADPNL----------A----P----------R--L--------------------------------------L----------------------------P------------------------------------R-----------------------------P-------------E----------SD---VE-------FLHGILESIA----------------R---I---------------EGKGYKLLKELGATE------AEEVL---------T----------A------G--------G---GAKNDKWIKIRQR---VLGLPVKKAVH----TEASYGASLLALKGAKQNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15 HHSearch 57.2719% 16 - C5 - - 2OQC - YXEI_BACSU B:[1-294] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CTSLTLE---T---A--DRKHVLARTMDFAFQ--------------L------------------GTE-----------V-----IL-Y--------------PR--------------RYSWNSEADGRAHQT--Q--------------YAFIG--M--GR----KL-G--N----ILFADG--IN----------------ESGL-SCAALY-FPGY-AEY---EKTI-------RED-TVHIVPHEFVTWVLSVCQSLEDVKEKIRSL------T------------IVEKKLDLLDTV----------LPLHWILS-DRTGRNL---TIEPRADGL-KVYD--------------------N----QPGVMTNS----------P----DFIWHVTNLQQY--T--------------------------------------GIRPKQLEAFGQGLGTVGL----------PGD----------------------------------Y-----------------------------T-------------P----------PS---RF-------VRAVYLKEHL----------------E---PAAD------------ETKGVTAAFQILANMTI----PKG-----------AVITEED----E------I--------H---YTQYTSVMCNETG---NYYFHHY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27 Fugue 55.5216% -32 - C3 - - 4XGC - ? C:[1-676] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQPFYEEYRKAWNQINDHIADLQHRSYARTLEQLVDFVVGQAERDEVLPTAALLTGINQPDHLSQFTALTQRLHAQRAAMVCVL-------QSRDCATLKAAVETLVFGLVEDNAEVEQLRRSQ-------CTMKQLKS-----WYT---NNFDSEQKRR--QLVVILPDFE------CFN---ASVL---------QDLILIL--S---AHCGSLPFVLVLGVATA-MTA------VHGTLPYHVSSKIRLRVFQTQAAPTGLNEVLDKVLLSPKYAF-HLSGKTF-------K--FLTHIFLY---Y---D--FSIHGFIQGFKYCLM--------------EHFFGGNAF---ALCTDYSKAL--G---R-I--K-----QLTH--------------ED--------------M----------------E--------------TIRRL--P--SF----R--P--Y----VEQIND--CKRIIAVLTDDDYLKKKLPQLL-RDCLLH-FLLFRCSLEFLTELVGDLPRCPLGKLRRELYVNCLNRAIIS-TPEYKECLQMLSFL------------------------------------------------SKDEFVAKV---NRALERTEQFLVEE---------------IAPLELG---EACTAVLR----------P----K----------L--E--------------------------------------A----------------------------I------------------------------------R-----------------------------L-------------A----------VD---EV-------GRALQKTLQL----------------I---E---------------TQIVQDHLRALQDAP------P-------------I----------HELFVFSD--------I---ATVRRNIIGAPRA---ALHTALNNPHF----PDLSVVYKLHLECGRMINLFDWLQAFRSVVPQIQARFTRAVAELQFLGYIKMSKRKTDHATRLTW----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12 HHSearch 55.2516% 23 - C5 - - 5HKE - ? A:[3-295] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAITLN---G-------NSNYFGRNLDLDFS--------------Y------------------GEE-----------V-----II-T--------------PA--------------E----------------YEFKFRKEKAIKNH-KSLIG--V--GIVA--N--D--Y----PLYFDA--IN----------------EDGL-GMAGLN-FPGN-AYY---SDAL-------END-KDNITPFEFIPWILGQCSDVNEARNLVEKI------N------------L----------INLSFSEQLPLAGLHWLIA-DREK-SI---VVEVTKSGV-HIYD---------------------N---PIGILTNN----------PEFNYQMYNLNK----Y--R--------------------------------------NLSISTPQNTFSDSVDLKVDGTGFGGIGLPGD----------------------------------V-----------------------------S-------------P----------ES---RF-------VRATFSKLNS----------------SKGMT---------------VEEDITQFFHILGTVEQIK--G-------------V----------NKTESGKE--------E---YTVYSNCYDLDNK---TLYYTTY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14 HHSearch 53.9013% -11 - C5 - - 2HF0 - ? B:[1-291] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CTGVRFS---D---D--EGNTYFGRNLDWSFS--------------YG------------------ET--------I--------LV-T--------------PR--------------G----------------YHYDTVFGAGGKAKPNAVIGVGV--VM----A--D--R----PMYFDC--AN----------------EHGL-AIAGLN-FPGY-ASF---VHEP-------VEG-TENVATFEFPLWVARNFDSVDEVEETLRNV------T------------LVSQIVPGQQ-E----------SLLHWFIG-DGKR-SI---VVEQMADGM-HVHH--------------------D----DVDVLTNQ----------P----TFDFHMENLRNY--M--------------------------------------CVSNEMAEPTSWGKASLTAWGAGVGMHGIPGD----------------------------------V-----------------------------S-------------S----------PS---RF-------VRVAYTNAHY----------------PQQND---------------EAANVSRLFHTLGSV------QMVDG---------M----------AKMGDGQF--------E---RTLFTSGYSSKTN---TYYMNTY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3 HHSearch 53.3619% 33 - C5 - - 4WL2 - ? C:[1-296] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CTRFVYL---D---PHNPDYPITARSMDWADD--------------TE----TNL---WIFPQELKRS--G---G-AGQY-----SL-E--------------WT--------------S----------------K--------------YGSVI--A--SA----F--D--GRKGMASTTDG--VN----------------EKGL-AANVLW-LAE--SEY---PKTKP------TAK-KPGLSVAAWAQYVLDNFATVDEAVKSLQQE------KFILVTKQVEGQKR----------L----------ATLHLSLS-DSSGDSA---IIEYIDGKQ-VIHH--------------------SK---NYQVMTNS----------P----T----------F--DQQLTLNAYWD----------------------------QIGGNVML---------------------PGT----------------------------------N-----------------------------R-------------A----------AD---RF-------VRASFYVKNV----------------N---PNKLIPGVAEKGKIEKDKADLATAFSIIRNASVPY--G-------------Y----------SLPDMPNI--------A---STRWRTVVDHKSL---QYFFESAVSP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18 HHSearch 51.6516% 38 - C5 - - 5INR ? C:[9-329] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CTSILVG---KKASI--DGSTLISRNDDGHEA--------------L-D--PQRF---VVVNPEDQPRDYTSVIS-K--VN----VK-L--------------PD--------------D----------------P--------------QRYTS--I--PNSILTN--G--I----WPA-AG--IN----------------SSNV-AMSATE-TITTNSRVQ--GLD--------PFV-ENGLGEEDLVTVVLPYVKSAREGVKRLGSLLEEY--G------------T----------Y----------EPNGISFA-DN-EEVW---WLETIGGHHWAAVR---------------IP---DD---AYVVAPNR--------------------------M--N--------------------------------------I----------------------------D------------------------------------QFDFDSDDTLCSSDLKDLIDNNNLNPDFENYNLRHIF-------GSASIKDTVYNNP---RT-------WYGQKFFSPDDTADDPMEQDLPFICHA---N---------------RKISVEDVKFVLSSHFENT--KYDVYGSGSQSD--K----------TLFRPIGI--------N---RNHNVHILQIRN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11 HHSearch 51.5814% 16 - C5 - - 3GVZ - ? B:[26-259] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CTLWGAA---G---TASMEGSLLAKNRDWKPD--------------------------------HAQS--L---R----------LL-H--------------PE--------------H----------------G--------------YAYLG--L--YA----DNGS--E----PGIKAG--VN----------------QKGL-AVVAAE-ASSLPR-A---------------LR-------GVLTR-LLRDYGSLDEVASAADKLF-----A------------Q----------A----------RPVFLLLA-DAGG-LM---QVEIGQHGRYRLIR---------------Q----QS---GTLAHTNH--------------------------Y--A--------------------------------------D----------------------------TSLLDGAQTIG--------------------------P-----------------------------S-------------S----------QA---RL-------ERIRFLLDQH------------------------------------PAHTLSEFERLSRDRHDGPDNS-------------L----------W------R--------SGREHTLAGWRIALPAGAPPRLQLTLA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17 HHSearch 49.3615% 34 - C5 - - 5IMG - ? D:[7-329] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G--SATSILVGKKAS---I--DGSTLISRNDDGHEA--------------L-D--PQRF---VVVNPEDQPRDYTSVISKV--N-----VK-L--------------PD--------------D----------------P--------------QRYTS--I--PNSILTN--G--I----WPA-AG--IN----------------SSNV-AMSATE-TITTNSRVQ--GLD--------PFV-ENGLGEEDLVTVVLPYVKSAREGVKRLGSLLEEY--G------------T----------Y----------EPNGISFA-DN-EEVW---WLETIGGHHWAAVR---------------IP---DD---AYVVAPNR--------------------------M--N--------------------------------------I----------------------------D------------------------------------QFDFDSDDTLCSSDLKDLIDNNNLNPDFENYNLRHIFGSASIKDT----------VYNNPRT-------WYGQKFFSPDDTADDPMEQDLPFICHA---N---------------RKISVEDVKFVLSSHFENT--KYDVYGSGSQSD--K----------TLFRPIGI--------N---RNHNVHILQIRN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------