@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTK7: (2017-12-14 )
MKVLRVLVTTTALLAAGAAMADEAVVHDSYAFDKNQLIPVGARAEVGTTGYGGALLWQANPYVGLALGYNGGDISWTDDVSVNGTKYDLDMDNNNVYLNAEIRPWGASTNPWAQGLYIAAGAAYLDNDYDLAKRIGNGDTLSIDGKNYQQAVPGQEGGVRGKMSYKNDIAPYLGFGFAPKISKNWGVFGEVGAYYTGNPKVELTQYNLASVTGNPTSAQDAVDKEANEIRNDNKYEWMPVGKVGVNFYW
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10-----.......------------..20.-----......------.30........------40.....----...-50.---------.------.----.....60....------------------....70.-.-......80...----------....-.90..---------.---------...------..-100----....---------..--------.----110......--------..120-.....----------..-.130-.-..-.-...140.......150--.......--------------------------------160---........170..-----------..------..-..180--.-.-----------......-----.190....--...200.......210.......----.220.....------..230.......240......-----..----------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
K
V
L
R
V
L
V
T
T
------
T
A
L
L
A
AG------------AAMAD-----
E
A
V
VHD------SYAFDKN
Q
L
I
P------VGARAEV----GTT-GY
G
---------
G
------
A
----
L
L
WQANP
Y
V
G
L
------------------
A
L
GYNGG-D-
I
S
W
TDD
V
S
VNG----------
T
K
Y
D
-
L
DMDN---------N---------
N
V
Y
------
L
N
-
A
E
I
----
R
PWG---------AS--------T----NP-WAQ
G
L
Y
--------
I
AAG--AAYLD----------N
D
-
Y
D
L
A
-
K
-RI-G-NG
D
T
L
S
IDGK
N
Y
Q
QAV--PGQEGGV--------------------------------R-G---KMSYKNDI
A
P
-
Y
L-----------GF------GF-APK----I-S-----------KNWGVF-----GEVG
A
Y
YT--GNP
K
V
E
L
T
Q
Y
N
L
A
SV-TGNPTS
A
----
Q
D
A
V
D
K
E
A
N
------
E
IRNDNK
Y
E
W
M
P
V
-
G
K
VG
V
N
F-----YW----------------------------------------------------------------------------------------------------------------------
31
HHSearch
90.03
99%
-
- C4 -
-
4RL9
-
?
B:
[17-227]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
------
V
G
A
R
A
E
V
----
G
T
T
-
G
Y
G
---------
G
------
A
----
L
L
W
Q
A
N
P
Y
V
G
L
------------------
A
L
G
Y
N
G
G
-
D
-
I
S
W
T
D
D
V
S
V
N
G
----------
T
K
Y
D
-
L
D
M
D
N
---------
N
---------
N
V
Y
------
L
N
-
A
E
I
----
R
----------------------------
P
-
W
A
Q
G
L
Y
--------
I
A
A
G
--
A
A
Y
L
D
----------
N
D
-
Y
D
L
A
-
K
-
R
I
-
G
-
N
G
D
T
L
S
I
D
G
K
N
Y
Q
Q
A
V
--
P
G
Q
E
G
G
V
--------------------------------
R
-
G
---
K
M
S
Y
K
N
D
I
A
P
-
Y
L
-----------
G
F
------
G
F
-
A
P
K
----
I
-
S
-----------
K
N
W
G
V
F
-----
G
E
V
G
A
Y
Y
T
--
G
N
P
K
V
E
L
T
Q
Y
N
-
L
A
P
V
T
G
N
P
T
S
A
----
Q
D
A
V
D
K
E
A
N
------
E
I
R
N
D
N
K
Y
E
W
M
P
V
-
G
K
V
G
V
N
F
-----
Y
-----------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.85
95%
-
- C4 -
-
4RL9
-
?
A:
[17-228]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
------
V
G
A
R
A
E
V
----
G
T
T
-
G
Y
G
---------
G
------
A
----
L
L
W
Q
A
N
P
Y
V
G
L
------------------
A
L
G
Y
N
G
G
-
D
-
I
S
W
T
D
-----------------
K
Y
D
-
L
D
M
D
N
---------
N
---------
N
V
Y
------
L
N
-
A
E
I
----
R
P
W
G
---------
A
S
--------
T
----
N
P
-
W
A
Q
G
L
Y
--------
I
A
A
G
--
A
A
Y
L
D
----------
N
D
-
Y
D
L
A
-
K
-
R
I
-
G
-
N
G
D
T
L
S
I
D
G
K
N
Y
Q
Q
A
V
--
P
G
Q
E
G
G
V
--------------------------------
R
-
G
---
K
M
S
Y
K
N
D
I
A
P
-
Y
L
-----------
G
F
------
G
F
-
A
P
K
----
I
-
S
-----------
K
N
W
G
V
F
-----
G
E
V
G
A
Y
Y
T
--
G
N
P
K
V
E
L
T
Q
Y
N
L
A
P
V
-
T
G
N
P
T
S
A
----
Q
D
A
V
D
K
E
A
N
------
E
I
R
N
D
N
K
Y
E
W
M
P
V
-
G
K
V
G
V
N
F
-----
Y
W
----------------------------------------------------------------------------------------------------------------------
21
Fugue
84.96
72%
-0
- C4 -
-
4FUV
8
?
A:
[13-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
Q
L
I
P
------
V
G
A
R
A
E
V
----
G
T
T
-
G
Y
G
---------
G
------
A
----
L
L
W
Q
A
N
P
Y
V
G
L
------------------
A
L
G
Y
N
G
G
-
D
-
I
S
W
S
D
D
V
K
V
N
G
----------
S
T
Y
D
-
L
D
M
D
N
---------
N
---------
N
V
Y
------
L
N
-
A
E
I
----
R
P
W
G
---------
A
S
--------
T
----
N
R
-
W
A
Q
G
L
Y
--------
V
A
A
G
--
A
A
Y
L
D
----------
N
D
-
Y
D
L
T
-
R
-
N
V
-
D
-
A
T
R
S
F
R
V
N
N
Q
D
F
I
A
----
G
A
D
G
V
K
I
--------------------------------
N
-
G
---
Q
M
S
Y
K
N
D
I
A
P
-
Y
L
-----------
G
F
------
G
F
-
A
P
K
----
I
-
N
-----------
K
N
W
G
V
F
-----
G
E
V
G
A
Y
Y
T
--
G
N
P
T
V
K
L
V
S
S
G
S
A
V
T
-
T
G
D
Q
S
-
L
----
E
E
A
V
N
A
E
A
R
------
K
I
A
N
D
D
K
Y
K
W
L
P
V
-
G
K
V
G
V
N
F
-----
F
W
----------------------------------------------------------------------------------------------------------------------
32
HHSearch
84.66
74%
0
- C4 -
-
4FUV
8
?
A:
[13-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
Q
L
I
P
------
V
G
A
R
A
E
V
----
G
T
T
-
G
Y
G
---------
G
------
A
----
L
L
W
Q
A
N
P
Y
V
G
L
------------------
A
L
G
Y
N
G
G
-
D
-
I
S
W
S
D
D
V
K
V
N
G
----------
S
T
Y
D
-
L
D
M
D
N
---------
N
---------
N
V
Y
------
L
N
-
A
E
I
----
R
P
W
G
---------
A
S
--------
T
----
N
R
-
W
A
Q
G
L
Y
--------
V
A
A
G
--
A
A
Y
L
D
----------
N
D
-
Y
D
L
T
-
R
-
N
V
-
D
-
A
T
R
S
F
R
V
N
N
Q
D
F
I
A
G
----
A
D
G
V
K
I
--------------------------------
N
-
G
---
Q
M
S
Y
K
N
D
I
A
P
-
Y
L
-----------
G
F
------
G
F
-
A
P
K
----
I
-
N
-----------
K
N
W
G
V
F
-----
G
E
V
G
A
Y
Y
T
--
G
N
P
T
V
K
L
V
S
S
G
S
-
A
V
-
T
T
G
D
Q
S
L
----
E
E
A
V
N
A
E
A
R
------
K
I
A
N
D
D
K
Y
K
W
L
P
V
-
G
K
V
G
V
N
F
-----
F
W
----------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.40
73%
-2
- C4 -
-
4FUV
8
?
A:
[13-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
Q
L
I
P
------
V
G
A
R
A
E
V
----
G
T
T
-
G
Y
G
---------
G
------
A
----
L
L
W
Q
A
N
P
Y
V
G
L
------------------
A
L
G
Y
N
G
G
-
D
-
I
S
W
S
D
D
V
K
V
N
G
----------
S
T
Y
D
-
L
D
M
D
N
---------
N
---------
N
V
Y
------
L
N
-
A
E
I
----
R
P
W
G
---------
A
S
--------
T
----
N
R
-
W
A
Q
G
L
Y
--------
V
A
A
G
--
A
A
Y
L
D
----------
N
D
-
Y
D
L
T
-
R
-
N
V
-
D
-
A
T
R
S
F
R
V
N
N
Q
D
F
I
A
G
A
--
D
G
V
K
--
I
--------------------------------
N
-
G
---
Q
M
S
Y
K
N
D
I
A
P
-
Y
L
-----------
G
F
------
G
F
-
A
P
K
----
I
-
N
-----------
K
N
W
G
V
F
-----
G
E
V
G
A
Y
Y
T
--
G
N
P
T
V
K
L
V
S
S
G
S
A
V
T
-
T
G
D
-
Q
S
L
----
E
E
A
V
N
A
E
A
R
------
K
I
A
N
D
D
K
Y
K
W
L
P
V
-
G
K
V
G
V
N
F
-----
F
W
----------------------------------------------------------------------------------------------------------------------
33
HHSearch
75.82
71%
-
- C4 -
-
4RLB
-
?
A:
[14-226]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
L
I
P
------
V
G
A
R
A
E
V
----
G
T
T
-
G
Y
G
---------
G
------
A
----
L
L
W
Q
A
N
P
Y
V
G
L
------------------
A
L
G
Y
N
G
G
-
D
-
I
S
W
S
D
D
L
S
I
N
G
----------
T
K
Y
D
-
M
D
M
D
N
---------
K
---------
L
A
Y
------
L
N
-
A
E
I
----
R
P
W
G
---------
A
S
--------
T
----
N
P
-
W
A
Q
G
L
Y
--------
V
A
A
G
--
A
A
Y
V
D
----------
N
Q
-
Y
D
L
T
-
K
-
N
V
-
G
-
T
N
A
S
V
E
I
D
G
N
R
F
N
G
G
----
A
N
G
V
S
I
--------------------------------
A
-
G
---
N
L
K
Y
D
N
D
I
A
P
-
Y
I
-----------
G
F
------
G
F
-
A
P
K
----
F
-
S
-----------
K
N
W
G
V
F
-----
G
E
V
G
A
Y
Y
S
--
G
N
P
K
V
S
L
A
S
N
N
D
A
L
I
-
G
S
D
G
R
T
L
----
G
K
T
L
D
D
Q
E
R
------
K
I
A
N
D
D
K
Y
K
W
L
P
V
-
G
K
V
G
V
N
F
-----
Y
W
----------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.19
68%
-
- C4 -
-
4RLB
-
?
A:
[14-226]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
L
I
P
------
V
G
A
R
A
E
V
----
G
T
T
-
G
Y
G
---------
G
------
A
----
L
L
W
Q
A
N
P
Y
V
G
L
------------------
A
L
G
Y
N
G
G
-
D
-
I
S
W
S
D
D
L
S
I
N
G
----------
T
K
Y
D
-
M
D
M
D
N
---------
K
---------
L
A
Y
------
L
N
-
A
E
I
----
R
P
W
G
---------
A
S
--------
T
----
N
P
-
W
A
Q
G
L
Y
--------
V
A
A
G
--
A
A
Y
V
D
----------
N
Q
-
Y
D
L
T
-
K
-
N
V
-
G
-
T
N
A
S
V
E
I
D
G
N
R
F
N
G
G
A
--
N
G
V
S
--
I
--------------------------------
A
-
G
---
N
L
K
Y
D
N
D
I
A
P
-
Y
I
-----------
G
F
------
G
F
-
A
P
K
----
F
-
S
-----------
K
N
W
G
V
F
-----
G
E
V
G
A
Y
Y
S
--
G
N
P
K
V
S
L
A
S
N
N
D
A
L
I
-
G
S
D
G
R
T
L
----
G
K
T
L
D
D
Q
E
R
------
K
I
A
N
D
D
K
Y
K
W
L
P
V
-
G
K
V
G
V
N
F
-----
Y
W
----------------------------------------------------------------------------------------------------------------------
30
Fugue
54.47
23%
-69
- C3 -
-
4DQJ
2
?
A:
[14-150]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
R
F
T
T
------
A
E
V
D
S
A
V
------------
A
R
I
S
Q
-----
K
I
G
V
P
A
------
S
Y
Y
---
Q
F
L
I
P
------
I
E
N
---------
F
V
-
V
A
G
---------
G
------
F
----
E
T
T
V
S
G
S
F
R
G
L
------------------
G
-------------------------------
Q
F
N
-
R
Q
T
W
D
---------
G
---------
L
R
R
------
L
G
-
R
N
L
----
P
A
F
E
---------
E
G
--------
S
----
A
Q
-
L
N
A
S
L
Y
---------
A
I
G
--
F
L
Y
L
E
----------
N
K
-
R
A
Y
E
-
A
-
S
F
K
G
-
R
V
F
T
H
E
I
A
Y
L
Y
H
N
Q
G
A
--
P
A
A
E
Q
Y
L
--------------------------------
T
S
G
---
R
L
V
Y
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
44.83
21%
15
- C1 -
-
5TZJ
1
?
A:
[1-349]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
F
S
V
I
V
P
T
Y
NSEKY
I
T
E
L
L
N
S
L
------------
A
K
Q
D
F
PKTE
F
E
V
V
V
V
D
------
D
C
S
T
D
Q
T
L
Q
I
V
E
K
Y
R
NK
L
N
L
K
V
S
Q
----
L
E
T
-
N
S
G
---------
G
P
G
K
P
R
N
V
----
A
L
K
Q
A
E
G
E
F
V
L
F
V
D
SD
D
Y
I
N
KE
T
L
K
D
A
A
A
F
I
D
E
H
H
S
-
D
-
V
L
L
I
K
M
K
G
V
N
G
R
G
V
P
Q
SMFKE
T
A
P
E
-
V
T
L
L
N
---------
S
RIIYTLSPT
K
I
Y
------
R
T
-
A
L
L
----
K
D
N
D
IYFPEELKS
A
E
--------
D
----
Q
L
-
F
T
M
K
A
Y
--------
L
N
A
N
R
I
S
V
L
S
D
----------
K
A
-
Y
Y
Y
A
T
K
-
R
E
-
G
E
H
M
S
S
A
Y
V
S
P
E
D
F
Y
E
V
M
--
R
L
I
A
V
E
I
--------------------------------
L
-
N
ADL
E
E
A
H
K
D
Q
I
L
A
-
E
F
L
N
R
H
F
S
FSRTN
G
F
------
S
L
-
K
V
K
----
L
-
E
-----------
E
Q
P
Q
W
I
-----
N
A
L
G
D
F
I
Q
--
A
V
P
-
E
R
V
D
A
L
V
M
S
K
L
-
R
P
L
L
H
Y
A
R
A
KD
I
D
N
Y
R
T
V
E
E
------
S
Y
R
Q
G
Q
Y
Y
R
F
D
I
V
D
G
K
L
N
I
Q
F
NEG
E
P
Y
F
E
GID------------------------------------------------------------------------------------------------------------------
38
HHSearch
42.10
17%
-41
- C4 -
-
2MHL
-
?
A:
[37-160]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
-
Q
L
G
---------
L
------
T
----
F
T
Y
M
A
T
D
N
I
G
V
------------------
E
L
L
A
A
T
P
-
F
R
H
K
I
G
T
R
----
A
----------
T
G
D
I
-
A
T
V
H
H
---------
L
---------
P
P
T
------
L
M
-
A
Q
W
----
Y
F
G
D
---------
A
S
-------------
S
K
-
F
--
R
P
Y
--------
V
G
A
G
--
I
N
Y
T
T
----------
F
F
-
D
N
G
F
-
N
-
D
H
---------
G
K
E
----
A
-----
G
----
L
--------------------------------
S
-
D
---
L
S
L
-
K
D
S
W
G
A
-
A
G
-----------
Q
V
------
G
V
-
D
Y
L
----
I
-
N
-----------
R
D
W
L
V
N
-----
M
S
V
W
Y
M
D
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
38.90
12%
-5
* C5 *
-
2HJS
10
USG_PSEAE
A:
[5-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
L
N
V
A
V
V
G
----------
A
T
G
------------
S
V
G
E
A
-----
L
V
G
L
L
D
------
E
R
D
F
P
L
H
R
L
H
L
------
L
A
S
A
E
S
A
----
G
Q
R
M
G
F
A
---------
E
------
S
S
L
R
V
G
D
V
D
S
F
D
F
S
S
V
------------------
G
L
A
F
F
A
A
-
A
-
A
E
V
S
R
A
H
A
E
R
A
----------
R
A
A
G
C
S
V
I
D
L
---------
S
---------
G
A
L
EPSVAP
P
V
M
V
S
V
----
N
A
E
R
---------
L
A
SQAAP
F
L
L
S
----
S
P
-
C
A
V
A
A
E
--------
L
C
E
V
--
L
A
P
L
L
----------
A
T
-
L
D
C
R
-
Q
L
N
L
-
T
-
A
C
L
S
V
S
S
L
G
R
E
G
V
K
E
L
--
A
R
Q
T
A
E
L
L
N
A
R
P
L
E
P
R
LFDRQIAFNLLAQVGAVDAEGHS
A
-
I
---
E
R
R
I
F
A
E
V
Q
A
-
L
L
-----------
G
E
RI
G
P
L
N
V
T
-
C
I
Q
----
A
-
P
-----------
V
F
F
G
D
S
-----
L
S
V
T
L
Q
C
A
--
E
P
V
D
L
A
A
V
T
R
V
L
D
A
T
-
K
G
I
E
W
V
G
----
E
G
D
Y
P
T
V
V
G
------
D
A
L
G
Q
D
E
---
T
Y
V
-
G
R
V
R
A
G
Q
-----
A
D
PC
Q
V
N
L
W
I
V
S
DNVRKGAA
L
N
A
V
L
L
G
E
L
L
I
K
HYL-------------------------------------------------------------------------------------
27
Fugue
38.23
17%
27
* C3 *
-
4CI2
1
CRBN_CHICK
B:
[71-451]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MINFDTSLPTSHMYLGSDMEEFH
G
R
T
L
H
D
D
D
S
C
Q
V
I
P
V
L
P
H
V
------
M
V
M
L
I
P
G
Q
T
L
P
L
Q
L
F
H
P
Q
E
V
S
M
V
R
-----
N
L
I
Q
K
D
R
T
F
A
V
L
A
Y
S
N
V
R
E
R
E
A
H
------
F
G
T
T
A
E
I
Y
A
Y
R
E
E
Q
-
E
Y
G
I
E
T
V
K
V
K
A
I
G
------
R
----
Q
R
F
K
V
L
E
I
R
T
Q
------------------
S
D
G
I
Q
Q
A
-
K
-
V
Q
I
L
P
E
R
V
L
P
S
----------
T
M
S
A
-
V
Q
L
Q
S
LSRRHIRAF
R
---------
Q
W
W
------
Q
K
-
Y
Q
K
----
R
K
F
H
---------
C
A
--------
S
LTSW
P
P
-
W
L
Y
S
L
Y
D
A
E
T
L
M
E
R
V
K
R
Q
--
L
H
E
W
D
E
NLKDESLPT
N
P
-
I
D
F
S
-
Y
-
R
V
-
A
-
A
C
--
L
P
I
D
D
A
L
R
I
Q
L
L
K
I
G
S
A
I
Q
R
L
--------------------------------
R
-
C
---
E
L
D
I
M
N
K
C
T
S
-
L
C
-----------
C
K
------
Q
C
Q
D
T
E
----
I
-
T
-----------
T
K
N
E
I
F
SLSLC
G
P
M
A
A
Y
V
N
PH
G
Y
I
H
E
T
L
T
V
Y
K
A
C
N
L
-
N
L
S
G
R
P
S
----
T
E
------
H
------
S
W
F
P
G
Y
A
W
T
I
A
Q
C
-
R
I
C
G
N
H
M
-----
G
W
K
F
T
A
TKKDMSPQKFWGLTRSALLPR---------------------------------------------------------------------------------------------
35
HHSearch
37.22
13%
-26
* C4 *
-
2X27
10
?
X:
[45-174]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
-
Q
L
G
---------
L
------
T
----
F
T
Y
M
F
A
D
K
W
G
V
------------------
E
L
V
A
A
T
P
F
N
-
H
Q
V
D
V
K
G
L
--
L
----------
D
G
K
L
-
A
D
I
K
Q
---------
L
---------
P
P
T
------
L
L
-
L
Q
Y
----
Y
P
M
G
---------
G
T
--------
N
----
S
A
---
F
Q
P
Y
--------
G
G
L
G
--
V
N
Y
T
T
----------
F
F
-
D
E
D
L
-
A
-
S
N
-------
R
--
K
A
---
Q
G
-------------------------------------------
F
-
S
---
S
M
K
L
Q
D
S
W
G
L
-
A
G
-----------
E
L
------
G
F
-
D
Y
M
----
L
-
N
-----------
E
H
A
L
F
N
-----
M
A
V
W
Y
M
D
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
36.17
23%
87
- C2 -
-
5KDS
10
?
A:
[20-530]
HMASVLELEMRGD
S
I
S
E
A
K
K
R
KVWN
F
Q
D
W
Q
I
T
G
L
S
A
R
AG
D
K
I
T
V
Y
V
D
V
AEG
D
P
T
P
T
L
L
Y
K
Q
S
LTQHG
G
A
T
S
F
Q
L
K
P
G
K
N
E
I
T
I
P
E
I
NYESNGIPKDVIQ
G
G
D
L
F
F
T
NYKSDSQK
R
A
P
K
V
R
I
E
G
A
S
K
Y
P
V
F
I
L
GKSD
E
N
E
V
M
K
E
L
E
A
Y
V
E
K
I
K
A
E
PKTTPN
I
F
A
V
S
S
NK
S
L
E
F
V
Q
A
T
Y
A
L
D
W
Y
K
K
N
NKTP
K
Y
T
A
E
Q
W
D
Q
Y
I
A
D
A
M
G
F
W
GFDNSKDVN
S
D
F
N
F
R
I
M
PMVKNLSGGAFMNAGNG
V
I
G
I
R
PGN
Q
D
A
I
L
A
ANKG
W
G
V
A
H
E
L
G
H
N
F
DTG
G
R
T
I
V
E
V
T
N
N
------
M
M
P
L
F
F
E
------------
S
K
Y
K
T
-----
K
T
R
I
T
D
------
Q
N
I
W
E
N
N
------------
T
Y
P
K
V
----
G
L
D
-
D
Y
S
---------
N
------
N
----
E
L
------------------------------
Y
N
K
A
-
D
----
S
T
H
L
A
Q
L
A
----------
P
L
W
Q
-
L
Y
L
Y
D
---------
N
---------
T
F
Y
------
G
K
-
F
E
R
Q
F
R
E
R
D
F
G
---------
N
K
--------
N
----
R
E
-
D
I
Y
K
S
W
--------
V
V
A
A
--
S
D
A
M
E
----------
L
D
L
T
E
F
F
-
A
-
R
H
-
G
-----
I
R
V
D
D
K
V
K
E
D
L
A
--
K
Y
P
K
P
D
K
--------------------------------------
K
I
Y
Y
L
N
D
L
A
M
N
Y
K
-----------
G
D
------
G
F
----------------------------------------
T
--
E
N
A
K
V
S
V
S
T
----
S
G
-
S
N
G
N
I
K
L
----
S
F
S
V
D
D
E
N
K
DNIL
G
Y
E
I
R
R
D
G
K
Y
V
G
F
T
S
-
N
D
S
F
V
D
T
-----
K
S
NLDED
G
V
Y
V
V
T
P
Y
D
RKLNTLN
P
I
E
V
N--------------------------------------------------------------------------------------------
42
HHSearch
35.16
14%
-32
- C4 -
-
2LHF
-
?
A:
[37-145]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
N
T
G
-
T
W
G
---------
I
------
R
----
A
G
Q
-
Q
F
E
Q
G
R
Y
------------------
Y
A
T
Y
E
N
I
-
S
-
D
T
--
S
S
------------------
G
-
N
K
L
R
Q
---------
Q
---------
N
L
L
------
G
S
-
Y
D
A
----
F
L
P
I
---------
G
--------------
D
N
N
T
--
K
L
F
--------
G
G
A
T
--
L
G
L
V
K
----------
L
E
-
Q
D
G
K
-
G
------------------
F
K
-------------------------------------------------
R
D
S
-
D
V
G
Y
A
A
-
G
L
-----------
Q
A
------
G
I
-
L
Q
E
----
L
-
S
-----------
K
N
A
S
I
E
-----
G
G
Y
R
Y
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
34.74
15%
11
- C4 -
-
4RLC
3
PORF_PSEAE
A:
[97-153]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
L
R
P
-
Y
V
-----------
S
A
------
G
L
-
A
H
Q
----
N
I
T
N
I
N
SD
S
Q
G
R
Q
-
Q
M
T
M
A
N
-----
I
G
A
G
L
K
Y
Y
--
F
T
E
N
F
F
A
K
A
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
34.63
17%
-37
- C4 -
-
2F1V
1
OMPW_ECOLI
B:
[36-159]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
-
Q
L
G
---------
L
------
T
----
F
T
Y
M
A
T
D
N
I
G
V
------------------
E
L
L
A
A
T
P
-
F
R
H
K
I
G
T
--
R
--
A
----------
T
G
D
I
-
A
T
V
H
H
---------
L
---------
P
P
T
------
L
M
-
A
Q
W
----
Y
F
G
D
---------
A
S
-------------
S
K
-
F
--
R
P
Y
--------
V
G
A
G
--
I
N
Y
T
T
----------
F
F
-
D
N
G
F
-
N
-
D
H
-------
G
--
K
E
-------------
A
G
L
--------------------------------
S
-
D
---
L
S
L
-
K
D
S
W
G
A
-
A
G
-----------
Q
V
------
G
V
-
D
Y
L
----
I
-
N
-----------
R
D
W
L
V
N
-----
M
S
V
W
Y
M
D
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
33.89
17%
-14
- C4 -
-
2JMM
-
OMPA_ECOLI
A:
[22-134]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
L
-
G
A
G
---------
A
------
F
----
G
G
Y
Q
V
N
P
Y
V
G
F
------------------
E
M
G
Y
D
W
L
-
G
-
R
M
---
P
--------------------
R
K
A
Q
G
---------
V
---------
Q
L
T
------
A
K
-
L
G
Y
----
P
K
L
G
---------
T
--------------
D
D
-
L
--
D
I
Y
--------
T
R
L
G
--
G
M
V
W
R
----------
A
D
-
T
S
D
----
K
D
-
G
---------
N
G
-----------------------------------------------
Y
-
I
---
S
A
A
-
E
A
S
V
S
P
-
V
F
-----------
A
G
------
G
V
-
E
Y
V
IRRR
I
-
T
-----------
P
E
I
A
T
R
-----
L
E
Y
Q
W
T
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
32.46
21%
26
- C2 -
-
5DXF
-
?
B:
[18-528]
---------------------------------------------------------------------------------------------------P
K
E
F
E
G
K
G
KL
K
L
S
G
R
I
L
N
V
M
TSLPLQIVRGN
S
A
L
Y
S
S
Q
H
F
L
A
E
NKE
W
E
T
H
L
I
A
W
T
GDEE
D
K
S
K
I
E
K
K
L
CDASGTP
N
I
H
P
V
W
L
L
R
RDQG
R
W
R
K
Y
A
E
NVL
W
P
V
F
H
YIQPSDGKA
E
T
D
A
W
H
D
Y
V
K
F
N
E
A
Y
L
N
K
I
K
S
V
YKPG
D
I
I
W
I
H
D
YYLLL
L
P
Q
L
L
R
M
E
F
PN
A
Y
I
G
F
F
L
H
V
P
F
P
S
S
E
Y
F
R
C
L
S
K
R
------
S
Q
L
L
D
G
M
------------
L
G
-
A
D
-----
K
I
G
F
Q
-------
S
D
S
F
Q
R
H
-
F
I
S
------
C
C
A
R
V
L
G
----
C
E
V
-
N
-----------------------------------------------------------------
R
D
S
V
S
A
Y
G
----------------------------------------
T
T
------
I
S
-
V
E
T
----
L
P
I
G
---------
I
D
--------
T
----
E
K
-
I
E
H
D
A
F
----------
S
S
--
E
L
G
V
E
----------
E
K
-
V
Q
A
L
-
K
-
Q
V
-
Y
-
K
G
K
K
L
I
V
-
G
R
D
R
L
D
K
V
--
R
G
-------------------------------------------------
V
I
Q
K
-
L
E
-----------
G
F
------
E
I
-
F
L
D
----
M
-
Y
-----------
P
E
W
-------------------
R
E
T
V
V
L
I
Q
V
S
S
P
G
Y
-
S
H
S
---------
A
N
V
E
T
R
V
T
------
E
I
I
S
R
I
N
S
K
Y
G
N
L
-
N
H
T
P
V
L
H
-----
Y
Q
MRVA
K
E
E
Y
L
A
L
L
R
V
AD
L
A
L
I
TSVRDGMN
T
T
S
L
E
F
V
I
C
Q
K
YNN
S
P
L
I
L
S
EFT
G
T
A
T
V
L
KDAIMVNPWD
S
V
G
V
A
K
T
I
N
D
A
L
M
LS
T
K
E
K
V
S
L
E
S
K
L
Y
E
K
V
L
S
N
T
V
Q
N
W
T
S
T
F
I
C
D
I
L
S
H
SI
45
HHSearch
32.44
9%
19
- C4 -
-
2N2M
-
?
A:
[77-134]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
---
V
F
R
I
N
E
Y
V
S
L
-
Y
G
-----------
L
L
------
G
A
-
G
H
G
----
K
A
K
F
S
S
I
F
G
Q
S
E
S
R
S
K
T
S
L
A
-----
Y
G
A
G
L
Q
F
N
--
P
H
P
N
F
V
I
D
A
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------