@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKK5: (2017-10-27 )
MTVTTYIGLGSNLGDSRQILSEAITKLKSLGEVKVSKLYQSPPMGPQDQPNYLNAVAQLKTELLPLELLDQLQRFEQEAGRVRLRHWGERTLDLDLLIYGNEKIQNERLTVPHVGILQRDFVVIPLLDLDADLHINDQPLKNLELIQQPTLTVLADESWA
Atome Classification :
(67 SA)
.........10........20---........---30---.---.------.....---.40........50........60........70........80..-.-.....90........100.......110.......120.......130...--...-.140.......150.......160
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
V
T
T
Y
I
GLGSNLG
D
S
R
Q
I
L
S
---
E
A
I
T
K
L
K
S
---
L
G
---
E
---
V
------
K
V
S
K
L
---YQSPPMGPQDQ
P
N
Y
L
N
A
V
A
Q
L
K
T
ELL
P
L
E
L
L
D
Q
L
Q
R
F
E
Q
E
A
G
R
V
R
-
L
-
R
HWGER
T
L
D
L
D
L
L
I
YGNEKIQNERLTVPHVG
I
L
QR
D
F
V
V
I
P
L
LDLDADLHI--NDQ-PL
K
N
L
E
L
IQQP
T
L
T
V
LADESWA
98
Fugue
79.11
48%
-19
- C5 -
-
1CBK
1
HPPK_HAEIN
A:
[1-160]
-
M
I
T
A
Y
I
A
L
G
S
N
L
N
T
P
V
E
Q
L
H
---
A
A
L
K
A
I
S
Q
LSN
T
H
---
L
---
V
------
T
T
S
S
F
---
Y
K
S
K
P
L
G
P
Q
D
Q
P
D
Y
V
N
A
V
A
K
I
E
T
E
L
S
P
L
K
L
L
D
E
L
Q
R
I
E
N
E
Q
G
R
V
R
L--
R
R
W
G
E
R
T
L
D
L
D
I
L
L
Y
G
N
E
I
I
Q
N
E
R
L
T
I
P
H
Y
D
M
H
N
R
E
F
V
I
V
P
L
F
E
I
A
S
D
L
V
L
PN
S
Q
I
-
I
T
E
L
V
K
Q
F
A
D
H
K
M
I
K
L
N
P
----
83
HHSearch
77.92
50%
-26
- C5 -
-
1CBK
1
HPPK_HAEIN
B:
[1-158]
-
M
I
T
A
Y
I
A
L
G
S
N
L
N
T
P
V
E
Q
L
H
---
A
A
L
K
A
I
S
Q
---
L
S
NTH
L
---
V
------
T
T
S
S
F
---
Y
K
S
K
P
L
G
P
Q
D
Q
P
D
Y
V
N
A
V
A
K
I
E
T
E
L
S
P
L
K
L
L
D
E
L
Q
R
I
E
N
E
Q
G
R
V
R
-
L
-
R
R
W
G
E
R
T
L
D
L
D
I
L
L
Y
G
N
E
I
I
Q
N
E
R
L
T
I
P
H
Y
D
M
H
N
R
E
F
V
I
V
P
L
F
E
I
A
S
D
L
V
L
--
P
N
S
-
Q
I
I
T
E
L
V
K
Q
F
A
D
---
H
K
M
I
K
L
-
85
HHSearch
76.11
42%
-31
- C5 -
-
3IP0
2
HPPK_ECOLI
A:
[1-158]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
---
A
A
L
K
A
L
G
D
---
I
P
ESH
I
---
L
------
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
-
K
A
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
G
-
E
M
L
R
Q
I
L
H
T
R
A
F
---
D
K
L
N
K
W
-
84
HHSearch
76.09
41%
-41
- C5 -
-
3HSJ
2
HPPK_ECOLI
A:
[1-158]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
---
A
A
L
K
A
L
G
D
---
I
P
ESH
I
---
L
------
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
A
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
-
K
A
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
G
-
E
M
L
R
Q
I
L
H
T
R
A
F
---
D
K
L
N
K
W
-
60
PsiBlast_CBE
74.92
43%
-36
- C5 -
-
1RTZ
2
HPPK_ECOLI
A:
[1-133]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
---
A
A
L
K
A
L
G
D
---
I
P
---
E
SHI
L
------
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
-------
G
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
1
PsiBlast_PDB
74.76
57%
-26
- C5 -
-
1CBK
1
HPPK_HAEIN
A:
[2-135]
--
I
T
A
Y
I
A
L
G
S
N
L
N
T
P
V
E
Q
L
H
A
A
L
K
A
I
S
Q
L
S
N
---
T
H
---
L
---
V
------
T
T
S
S
F
---
Y
K
S
K
P
L
G
P
Q
D
Q
P
D
Y
V
N
A
V
A
K
I
E
T
E
L
S
P
L
K
L
L
D
E
L
Q
R
I
E
N
E
Q
G
R
V
R
-
L
-
R
R
W
G
E
R
T
L
D
L
D
I
L
L
Y
G
N
E
I
I
Q
N
E
R
L
T
I
P
H
Y
D
M
H
N
R
E
F
V
I
V
P
L
F
E
I
A
S
D
L
------------------------------
21
PsiBlast_CBE
74.23
57%
-25
- C5 -
-
1CBK
1
HPPK_HAEIN
B:
[2-135]
--
I
T
A
Y
I
A
L
G
S
N
L
N
T
P
V
E
Q
L
H
AAL
K
A
I
S
Q
L
S
N
---
T
H
---
L
---
V
------
T
T
S
S
F
---
Y
K
S
K
P
L
G
P
Q
D
Q
P
D
Y
V
N
A
V
A
K
I
E
T
E
L
S
P
L
K
L
L
D
E
L
Q
R
I
E
N
E
Q
G
R
V
R
-
L
-
R
R
W
G
E
R
T
L
D
L
D
I
L
L
Y
G
N
E
I
I
Q
N
E
R
L
T
I
P
H
Y
D
M
H
N
R
E
F
V
I
V
P
L
F
E
I
A
S
D
L
------------------------------
58
PsiBlast_CBE
74.18
43%
-30
- C5 -
-
1RU1
2
HPPK_ECOLI
B:
[1-133]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
---
A
A
L
K
A
L
G
D
---
I
P
---
E
SHI
L
------
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
-------
G
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
66
PsiBlast_CBE
73.15
40%
-44
- C5 -
-
5ETR
2
?
B:
[5-138]
--
I
Q
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
---
D
A
I
K
I
L
N
E
---
Y
D
---
G
---
I
------
S
V
S
N
I
SPI
Y
E
T
A
P
V
G
Y
T
E
Q
P
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
C
L
H
R
I
R
-
K
-
E
R
W
G
P
R
T
L
D
V
D
I
L
L
Y
G
E
E
M
I
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
A
N
V
------------------------------
82
HHSearch
73.10
43%
-37
- C5 -
-
2QX0
3
?
B:
[1-159]
-
M
I
R
V
Y
I
A
L
G
S
N
L
A
M
P
L
Q
Q
V
S
---
A
A
R
E
A
L
A
H
---
L
P
RSR
L
---
V
------
A
C
S
P
L
---
Y
R
T
K
P
L
G
P
Q
D
Q
P
D
F
L
N
A
V
V
A
L
D
T
S
L
P
P
E
Q
L
L
D
H
T
Q
A
I
E
R
N
Q
G
R
V
R
-
K
E
Q
R
W
G
P
R
T
L
D
L
D
I
M
L
Y
G
D
Q
V
I
K
T
D
R
L
T
I
P
H
Y
G
L
K
A
R
E
F
M
L
Y
P
L
A
D
I
A
P
D
L
I
F
--
P
D
G
-
E
S
L
S
E
C
L
K
R
V
D
K
---
N
G
L
V
L
W
-
75
PsiBlast_CBE
72.89
40%
-57
- C5 -
-
3QBC
2
?
B:
[5-138]
--
I
Q
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
---
D
A
I
K
I
L
N
E
---
Y
D
---
G
---
I
------
S
V
S
N
I
S
P
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
C
L
H
R
I
R
-
K
-
E
R
W
G
P
R
T
L
D
V
D
I
L
L
Y
G
E
E
M
I
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
A
N
V
------------------------------
62
PsiBlast_CBE
72.07
40%
-41
- C5 -
-
5ETT
2
?
B:
[5-138]
--
I
Q
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
---
D
A
I
K
I
L
N
E
---
Y
D
---
G
---
I
------
S
V
S
N
I
SPI
Y
E
T
A
P
V
G
Y
T
E
Q
P
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
C
L
H
R
I
R
-
K
-
E
R
W
G
P
R
T
L
D
V
D
I
L
L
Y
G
E
E
M
I
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
A
N
V
------------------------------
65
PsiBlast_CBE
72.02
40%
-42
- C5 -
-
5ETS
2
?
A:
[5-138]
--
I
Q
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
---
D
A
I
K
I
L
N
E
---
Y
D
---
G
---
I
------
S
V
S
N
I
SP
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
C
L
H
R
I
R
-
K
-
E
R
W
G
P
R
T
L
D
V
D
I
L
L
Y
G
E
E
M
I
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
A
N
V
------------------------------
72
PsiBlast_CBE
71.63
40%
-43
- C5 -
-
4CRJ
2
?
A:
[5-138]
--
I
Q
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
---
D
A
I
K
I
L
N
E
---
Y
D
---
G
---
I
------
S
V
S
N
I
S
P
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
C
L
H
R
I
R
-
K
-
E
R
W
G
P
R
T
L
D
V
D
I
L
L
Y
G
E
E
M
I
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
A
N
V
------------------------------
64
PsiBlast_CBE
71.54
40%
-40
- C5 -
-
5ETS
2
?
B:
[5-138]
--
I
Q
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
---
D
A
I
K
I
L
N
E
---
Y
D
---
G
---
I
------
S
V
S
N
I
SPI
Y
E
T
A
P
V
G
Y
T
E
Q
P
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
C
L
H
R
I
R
-
K
-
E
R
W
G
P
R
T
L
D
V
D
I
L
L
Y
G
E
E
M
I
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
A
N
V
------------------------------
67
PsiBlast_CBE
71.47
40%
-43
- C5 -
-
5ETR
2
?
A:
[5-138]
--
I
Q
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
---
D
A
I
K
I
L
N
E
---
Y
D
---
G
---
I
------
S
V
S
N
I
S
P
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
C
L
H
R
I
R
-
K
-
E
R
W
G
P
R
T
L
D
V
D
I
L
L
Y
G
E
E
M
I
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
A
N
V
------------------------------
22
PsiBlast_CBE
71.46
47%
10
- C5 -
-
5ETL
4
HPPK_ECOLI
D:
[4-143]
M
T
V
A
-
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
73
PsiBlast_CBE
71.39
40%
-57
- C5 -
-
4AD6
2
?
B:
[5-138]
--
I
Q
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
---
D
A
I
K
I
L
N
E
---
Y
D
---
G
---
I
------
S
V
S
N
I
SPI
Y
E
T
A
P
V
G
Y
T
E
Q
P
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
C
L
H
R
I
R
-
K
-
E
R
W
G
P
R
T
L
D
V
D
I
L
L
Y
G
E
E
M
I
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
A
N
V
------------------------------
76
PsiBlast_CBE
71.38
40%
-50
- C5 -
-
3QBC
2
?
A:
[5-138]
--
I
Q
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
---
D
A
I
K
I
L
N
E
---
Y
D
---
G
---
I
------
S
V
S
N
I
S
P
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
C
L
H
R
I
R
-
K
-
E
R
W
G
P
R
T
L
D
V
D
I
L
L
Y
G
E
E
M
I
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
A
N
V
------------------------------
71
PsiBlast_CBE
71.30
40%
-40
* C5 *
-
4CWB
2
?
A:
[5-138]
--
I
Q
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
---
D
A
I
K
I
L
N
E
---
Y
D
---
G
---
I
------
S
V
S
N
I
S
P
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
C
L
H
R
I
R
-
K
-
E
R
W
G
P
R
T
L
D
V
D
I
L
L
Y
G
E
E
M
I
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
A
N
V
------------------------------
63
PsiBlast_CBE
71.25
40%
-41
- C5 -
-
5ETT
2
?
A:
[5-138]
--
I
Q
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
---
D
A
I
K
I
L
N
E
---
Y
D
---
G
---
I
------
S
V
S
N
I
S
P
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
C
L
H
R
I
R
-
K
-
E
R
W
G
P
R
T
L
D
V
D
I
L
L
Y
G
E
E
M
I
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
A
N
V
------------------------------
74
PsiBlast_CBE
70.95
40%
-55
- C5 -
-
4AD6
2
?
A:
[5-138]
--
I
Q
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
---
D
A
I
K
I
L
N
E
---
Y
D
---
G
---
I
------
S
V
S
N
I
S
P
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
C
L
H
R
I
R
-
K
-
E
R
W
G
P
R
T
L
D
V
D
I
L
L
Y
G
E
E
M
I
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
A
N
V
------------------------------
57
PsiBlast_CBE
70.82
43%
-35
- C5 -
-
1RU2
2
HPPK_ECOLI
A:
[1-133]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
---
A
A
L
K
A
L
G
D
---
I
P
---
E
SHI
L
------
T
V
S
S
F
---
Y
R
T
P
P
------
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
-------
G
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
4
PsiBlast_PDB
70.62
47%
15
- C5 -
-
5ETM
2
HPPK_ECOLI
A:
[4-143]
M
T
V
A
-
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
12
PsiBlast_PDB
70.50
47%
13
- C5 -
-
4M5K
3
HPPK_ECOLI
A:
[4-143]
M
T
V
A
-
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
5
PsiBlast_PDB
70.43
47%
11
- C5 -
-
5ETN
2
HPPK_ECOLI
A:
[4-143]
M
T
V
A
-
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
9
PsiBlast_PDB
70.41
47%
12
- C5 -
-
4M5H
2
HPPK_ECOLI
A:
[4-143]
M
T
V
A
-
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
13
PsiBlast_PDB
70.25
47%
13
- C5 -
-
4M5L
3
HPPK_ECOLI
A:
[4-143]
M
T
V
A
-
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
10
PsiBlast_PDB
70.19
47%
14
- C5 -
-
4M5I
2
HPPK_ECOLI
A:
[4-143]
M
T
V
A
-
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
86
HHSearch
70.03
35%
-25
- C5 -
-
5ETR
2
?
B:
[4-156]
-
M
I
Q
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
---
D
A
I
K
I
L
N
E
---
Y
D
GIS
V
---
S
------
N
I
S
P
I
---
Y
E
T
A
P
V
G
Y
T
E
Q
P
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
C
L
H
R
I
R
-
K
-
E
R
W
G
P
R
T
L
D
V
D
I
L
L
Y
G
E
E
M
I
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
A
N
V
V
E
--
P
R
S
K
L
K
V
K
D
L
V
F
V
D
D
S
----------
8
PsiBlast_PDB
70.01
47%
15
- C5 -
-
4M5G
2
HPPK_ECOLI
A:
[4-143]
M
T
V
A
-
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
7
PsiBlast_PDB
69.95
47%
13
- C5 -
-
5ETP
2
HPPK_ECOLI
A:
[4-143]
M
T
V
A
-
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
14
PsiBlast_PDB
69.79
47%
19
- C5 -
-
4M5M
3
HPPK_ECOLI
A:
[4-143]
M
T
V
A
-
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
11
PsiBlast_PDB
69.64
47%
25
- C5 -
-
4M5J
2
HPPK_ECOLI
A:
[4-143]
M
T
V
A
-
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
---
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
48
PsiBlast_CBE
69.59
45%
7
- C5 -
-
3HSG
3
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
A
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
6
PsiBlast_PDB
69.51
47%
15
- C5 -
-
5ETO
2
HPPK_ECOLI
A:
[4-143]
M
T
V
A
-
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
30
PsiBlast_CBE
69.45
45%
21
- C5 -
-
3IP0
2
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
16
PsiBlast_PDB
69.28
45%
22
- C5 -
-
1DY3
2
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
45
PsiBlast_CBE
69.06
45%
19
- C5 -
-
3HSJ
2
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
A
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
40
PsiBlast_CBE
68.93
45%
20
- C5 -
-
1F9H
2
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
A
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
59
PsiBlast_CBE
68.83
43%
-38
- C5 -
-
1RU1
2
HPPK_ECOLI
A:
[1-133]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
---
A
A
L
K
A
L
G
D
---
I
P
---
E
SHI
L
------
T
V
S
S
F
---
Y
R
T
P
P
------
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
----------
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
29
PsiBlast_CBE
68.80
45%
19
- C5 -
-
3UD5
3
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
47
PsiBlast_CBE
68.72
45%
8
- C5 -
-
3HCX
1
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
A
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
3
PsiBlast_PDB
68.62
47%
13
- C5 -
-
5ETL
3
HPPK_ECOLI
A:
[4-143]
M
T
V
A
-
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K-------
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
49
PsiBlast_CBE
68.55
45%
17
- C5 -
-
3HSD
3
HPPK_ECOLI
B:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
A
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
87
HHSearch
68.50
35%
-34
- C5 -
-
3QBC
2
?
B:
[3-156]
H
M
I
Q
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
---
D
A
I
K
I
L
N
E
---
Y
D
GIS
V
---
S
------
N
I
S
P
I
---
Y
E
T
A
P
V
G
Y
T
E
Q
P
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
C
L
H
R
I
R
-
K
-
E
R
W
G
P
R
T
L
D
V
D
I
L
L
Y
G
E
E
M
I
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
A
N
V
V
E
--
P
R
S
K
L
K
V
K
D
L
V
F
V
D
D
S
----------
55
PsiBlast_CBE
68.42
45%
21
- C5 -
-
1TMM
3
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
A
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
37
PsiBlast_CBE
68.42
45%
18
- C5 -
-
1HQ2
2
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
A
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
32
PsiBlast_CBE
68.41
45%
25
- C5 -
-
1RAO
2
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
50
PsiBlast_CBE
68.38
45%
7
- C5 -
-
3HSD
2
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
A
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
41
PsiBlast_CBE
68.33
45%
21
- C5 -
-
3ILO
2
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
A
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
17
PsiBlast_PDB
68.25
45%
18
- C5 -
-
1EX8
1
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
23
PsiBlast_CBE
68.10
47%
13
- C5 -
-
5ETL
3
HPPK_ECOLI
C:
[4-143]
M
T
V
A
-
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-----
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
34
PsiBlast_CBE
68.05
45%
21
- C5 -
-
3HD2
2
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
A
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
53
PsiBlast_CBE
67.99
45%
18
- C5 -
-
3HSZ
2
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
A
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
20
PsiBlast_PDB
67.96
45%
22
- C5 -
-
1Q0N
2
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
18
PsiBlast_PDB
67.94
45%
25
- C5 -
-
1EQM
1
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
52
PsiBlast_CBE
67.84
45%
19
- C5 -
-
3HT0
1
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
A
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
46
PsiBlast_CBE
67.81
45%
18
- C5 -
-
3HD1
1
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
A
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
54
PsiBlast_CBE
67.57
45%
28
- C5 -
-
1TMM
3
HPPK_ECOLI
B:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
A
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
28
PsiBlast_CBE
67.56
45%
32
- C5 -
-
3UDE
1
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
-----
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
43
PsiBlast_CBE
67.14
45%
24
- C5 -
-
3ILJ
1
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
A
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
31
PsiBlast_CBE
66.44
45%
31
- C5 -
-
1RB0
1
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
51
PsiBlast_CBE
66.40
45%
23
- C5 -
-
3KUH
2
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
A
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
27
PsiBlast_CBE
66.29
45%
29
- C5 -
-
3UDV
1
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
-----
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
26
PsiBlast_CBE
66.29
45%
26
- C5 -
-
4F7V
1
HPPK_ECOLI
A:
[1-139]
--
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
-
E
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------
24
PsiBlast_CBE
66.07
47%
19
- C5 -
-
5ETL
3
HPPK_ECOLI
B:
[4-143]
M
T
V
A
-
Y
I
A
I
G
S
N
L
A
S
P
---
L
E
---
Q
V
N
A
A
L
K
A
---
L
G
---
D
---
I
PESHIL
T
V
S
S
F
---
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
-------
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
--
P
D
------------------------