@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U493: (2017-12-26 )
MQILGGNNMAFPQLDLKSEKGPKAVIKTNRGDITVQLFPELAPKTVQNFIELSKKGYYDGVIFHRVIPDFMIQGGDPTGTGMGGESIYGESFEDEFSRELFNLRGALSMANSGPNTNGSQFFIVNNTNVPANMLGQLEGAGFPSEIIEAYKGGGTPWLDFRHTVFGHVLEGMDTVDEIANVQRGPQDRPVHDVVIETIEISE
Atome Classification :
(93 SA)
.........10....-....20..-......30........40........50..----------.---------------...-..60........70.......-.-80.......-------------------------.-------------------------90.....-...100..-.----.-....110.---......120.......130.......140.......150.......160.......170.-........180.---..-.-------.-..190.......200
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
Q
ILGGNNMAFPQLD-LKSEKGP
K
-
A
V
I
KTNRG
D
I
T
V
Q
L
F
P
EL
A
P
K
T
V
Q
N
F
I
E
L
S
----------K---------------KGY-YD
G
V
I
F
H
RV
I
P
D
F
M
IQGGDPT-G-TGMGGESIY-------------------------G-------------------------E
S
F
E
D
E
F
-
S
R
E
L
-
F
N
L
-
R
----
G
-
A
L
S
MANSG---PNTNG
S
Q
F
F
I
V
NNTNV
P
A
N
M
L
G
Q
LEGAGF
P
S
E
I
I
E
A
Y
KGGGTP
W
L
D
F
R
H
T
V
F
G
H
V
L
E
--
G
-
M
D
T
V
D
E
I
A
N
VQR---GP-Q-------D-RPV
H
D
V
V
I
E
T
I
EISE
220
HHSearch
90.31
54%
-37
- C8 -
-
2A2N
1
C:
[13-176]
------------
Q
A
E
-
G
P
K
R
V
S
D
S
-
A
I
I
H
T
S
M
G
D
I
H
T
K
L
F
P
V
E
C
P
K
T
V
E
N
F
C
V
H
S
----------
R
---------------
N
G
Y
-
Y
N
G
H
T
F
H
R
I
I
K
G
F
M
I
Q
T
G
D
P
T
-
G
-
T
G
M
G
G
E
S
I
W
-------------------------
G
-------------------------
G
E
F
E
D
E
F
-
H
S
T
L
R
H
D
R
-
P
----
Y
-
T
L
S
M
A
N
A
G
---
S
N
T
N
G
S
Q
F
F
I
T
V
V
P
---------------------------
T
P
W
L
D
N
K
H
T
V
F
G
R
V
T
K
--
G
-
M
E
V
V
Q
R
I
S
N
V
K
V
---
N
P
K
T
-------
D
-
K
P
Y
E
D
V
S
I
I
N
I
T
V
K
-
217
HHSearch
88.29
51%
-40
- C8 -
-
2X7K
-
PPIL1_HUMAN
A:
[5-165]
--------------
P
-
P
D
S
W
Q
P
P
N
-
V
Y
L
E
T
S
M
G
I
I
V
L
E
L
Y
W
K
H
A
P
K
T
C
K
N
F
A
E
L
A
----------
R
---------------
R
G
Y
-
Y
N
G
T
K
F
H
R
I
I
K
D
F
M
I
Q
G
G
D
P
T
-
G
-
T
G
R
G
G
A
S
I
Y
-------------------------
G
-------------------------
K
Q
F
E
D
E
L
-
H
P
D
L
K
F
T
G
-
A
----
G
-
I
L
A
M
A
N
A
G
---
P
D
T
N
G
S
Q
F
F
V
T
L
A
P
---------------------------
T
Q
W
L
D
G
K
H
T
I
F
G
R
V
C
Q
--
G
-
I
G
M
V
N
R
V
G
M
V
E
T
---
N
S
-
Q
-------
D
-
R
P
V
D
D
V
K
I
I
K
A
Y
P
S
-
219
HHSearch
88.01
51%
-34
- C8 -
-
2OK3
-
PPIL3_HUMAN
A:
[1-156]
----------------------
M
S
-
V
T
L
H
T
D
V
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
L
A
L
C
----------
A
---------------
S
N
Y
-
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
D
P
T
-
G
-
T
G
R
G
G
N
S
I
W
-------------------------
G
-------------------------
K
K
F
E
D
E
Y
-
S
E
Y
L
K
H
N
V
-
R
----
G
-
V
V
S
M
A
N
N
G
---
P
N
T
N
G
S
Q
F
F
I
T
Y
G
K
---------------------------
Q
P
H
L
D
M
K
Y
T
V
F
G
K
V
I
D
--
G
-
L
E
T
L
D
E
L
E
K
L
P
V
---
N
E
K
T
-------
Y
-
R
P
L
N
D
V
H
I
K
D
I
T
I
H
A
226
HHSearch
87.99
51%
-7
- C8 -
-
1W74
-
PPIA_MYCTU
A:
[12-182]
-------------------
L
A
T
A
T
-
A
T
L
H
T
N
R
G
D
I
K
I
A
L
F
G
N
H
A
P
K
T
V
A
N
F
V
G
L
A
----------
Q
GTKDYSTQNASGGPS
G
P
F
-
Y
D
G
A
V
F
H
R
V
I
Q
G
F
M
I
Q
G
G
D
P
T
-
G
-
T
G
R
G
G
P
----------------------------
G
-------------------------
Y
K
F
A
D
E
F
-
H
P
E
L
Q
F
D
K
-
P
----
Y
-
L
L
A
M
A
N
A
G
---
P
G
T
N
G
S
Q
F
F
I
T
V
G
K
---------------------------
T
P
H
L
N
R
R
H
T
I
F
G
E
V
I
D
A
E
S
-
Q
R
V
V
E
A
I
S
K
T
A
T
---
D
G
-
N
-------
D
-
R
P
T
D
P
V
V
I
E
S
I
T
I
S
-
1
PsiBlast_PDB
87.84
48%
-29
- C8 -
-
2A2N
1
PPWD1_HUMAN
A:
[13-175]
------------
Q
A
E
-
G
P
K
R
V
S
D
S
-
A
I
I
H
T
S
M
G
D
I
H
T
K
L
F
P
V
E
C
P
K
T
V
E
N
F
C
V
H
S
----------
R
---------------
N
G
Y
-
Y
N
G
H
T
F
H
R
I
I
K
G
F
M
I
Q
T
G
D
P
T
-
G
-
T
G
M
G
G
E
S
I
W
-------------------------
G
-------------------------
G
E
F
E
D
E
F
-
H
S
T
L
-
R
H
D
-
R
----
P
Y
T
L
S
M
A
N
A
G
---
S
N
T
N
G
S
Q
F
F
I
---
T
V
V
P
------------------------
T
P
W
L
D
N
K
H
T
V
F
G
R
V
T
K
--
G
-
M
E
V
V
Q
R
I
S
N
V
K
V
---
N
P
-
K
T------
D
-
K
P
Y
E
D
V
S
I
I
N
I
T
V
--
21
PsiBlast_CBE
87.72
48%
-37
- C8 -
-
2A2N
1
C:
[12-175]
-----------
T
Q
A
E
-
G
P
K
R
V
S
D
S
-
A
I
I
H
T
S
M
G
D
I
H
T
K
L
F
P
V
E
C
P
K
T
V
E
N
F
C
V
H
S
----------
R
---------------
N
G
Y
-
Y
N
G
H
T
F
H
R
I
I
K
G
F
M
I
Q
T
G
D
P
T
-
G
-
T
G
M
G
G
E
S
I
W
-------------------------
G
-------------------------
G
E
F
E
D
E
F
-
H
S
T
L
-
R
H
D
-
R
----
P
Y
T
L
S
M
A
N
A
G
---
S
N
T
N
G
S
Q
F
F
I
---
T
V
V
P
------------------------
T
P
W
L
D
N
K
H
T
V
F
G
R
V
T
K
--
G
-
M
E
V
V
Q
R
I
S
N
V
K
V
---
N
P
-
K
T------
D
-
K
P
Y
E
D
V
S
I
I
N
I
T
V
--
224
HHSearch
86.38
51%
-39
- C8 -
-
2FU0
-
?
A:
[5-159]
---------------------
P
K
S
-
A
I
I
Y
T
T
M
G
D
I
H
I
S
L
F
Y
K
E
C
K
K
T
V
Q
N
F
S
V
H
S
----------
I
---------------
N
G
Y
-
Y
N
N
C
I
F
H
R
V
I
K
H
F
M
V
Q
T
G
D
P
S
-
G
-
D
G
T
G
G
E
S
I
W
-------------------------
G
-------------------------
N
E
F
E
D
E
F
-
F
D
H
L
N
H
S
K
-
P
----
F
-
M
V
S
M
A
N
C
G
---
P
N
T
N
G
S
Q
F
F
I
T
T
V
P
---------------------------
C
P
W
L
D
F
K
H
T
V
F
G
K
V
T
Q
--
G
-
S
K
I
V
L
D
I
E
K
V
R
T
---
D
K
-
R
-------
D
-
K
P
L
E
D
I
K
I
L
N
I
K
I
N
-
222
HHSearch
85.56
49%
-30
- C8 -
-
1ZKC
1
PPIL2_HUMAN
A:
[14-175]
----------------
L
V
P
R
G
S
G
Y
-
V
R
L
H
T
N
K
G
D
L
N
L
E
L
H
C
D
L
T
P
K
T
C
E
N
F
I
R
L
C
----------
K
---------------
K
H
Y
-
Y
D
G
T
I
F
H
R
S
I
R
N
F
V
I
Q
G
G
D
P
T
-
G
-
T
G
T
G
G
E
S
Y
W
-------------------------
G
-------------------------
K
P
F
K
D
E
F
-
R
P
N
L
S
H
T
G
-
R
----
G
-
I
L
S
M
A
N
S
G
---
P
N
S
N
R
S
Q
F
F
I
T
F
R
S
---------------------------
C
A
Y
L
D
K
K
H
T
I
F
G
R
V
V
G
--
G
-
F
D
V
L
T
A
M
E
N
V
E
S
---
D
P
K
T
-------
D
-
R
P
K
E
E
I
R
I
D
A
T
T
V
F
V
7
PsiBlast_PDB
85.37
44%
-41
- C8 -
-
1XYH
-
PPIL3_HUMAN
A:
[3-154]
-------------------------
V
T
L
H
T
D
V
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
L
A
L
C
----------
A
---------------
S
N
Y
-
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
D
P
T
-
G
-
T
G
R
G
G
N
S
I
W
-------------------------
G
-------------------------
K
K
F
E
D
E
Y
-
S
E
Y
L
K
H
N
V
-
R
----
G
-
V
V
S
M
A
N
N
G
---
P
N
T
N
G
S
Q
F
F
I
T
Y
---------------------------
G
K
Q
P
H
L
D
M
K
Y
T
V
F
G
K
V
I
D
--
G
-
L
E
T
L
D
E
L
E
K
L
P
V
---
N
E
-
K
-------
T
Y
R
P
L
N
D
V
H
I
K
D
I
T
I
--
8
PsiBlast_PDB
85.36
44%
-38
- C8 -
-
2OK3
-
PPIL3_HUMAN
A:
[3-154]
-------------------------
V
T
L
H
T
D
V
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
L
A
L
C
----------
A
---------------
S
N
Y
-
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
D
P
T
-
G
-
T
G
R
G
G
N
S
I
W
-------------------------
G
-------------------------
K
K
F
E
D
E
Y
-
S
E
Y
L
K
H
N
V
-
R
----
G
-
V
V
S
M
A
N
N
G
---
P
N
T
N
G
S
Q
F
F
I
T
Y
---------------------------
G
K
Q
P
H
L
D
M
K
Y
T
V
F
G
K
V
I
D
--
G
-
L
E
T
L
D
E
L
E
K
L
P
V
---
N
E
-
K
-------
T
Y
R
P
L
N
D
V
H
I
K
D
I
T
I
--
225
HHSearch
85.27
51%
-44
- C8 -
-
2K7N
-
PPIL1_HUMAN
A:
[5-165]
--------------
P
-
P
D
S
W
Q
P
P
N
-
V
Y
L
E
T
S
M
G
I
I
V
L
E
L
Y
W
K
H
A
P
K
T
C
K
N
F
A
E
L
A
----------
R
---------------
R
G
Y
-
Y
N
G
T
K
F
H
R
I
I
K
D
F
M
I
Q
G
G
D
P
T
-
G
-
T
G
R
G
G
A
S
I
Y
-------------------------
G
-------------------------
K
Q
F
E
D
E
L
-
H
P
D
L
K
F
T
G
-
A
----
G
-
I
L
A
M
A
N
A
G
---
P
D
T
N
G
S
Q
F
F
V
T
L
A
P
---------------------------
T
Q
W
L
D
G
K
H
T
I
F
G
R
V
C
Q
--
G
-
I
G
M
V
N
R
V
G
M
V
E
T
---
N
S
-
Q
-------
D
-
R
P
V
D
D
V
K
I
I
K
A
Y
P
S
-
221
HHSearch
84.80
48%
-37
- C8 -
-
2B71
-
?
A:
[33-191]
----------------
K
G
H
T
E
R
G
Y
-
I
T
I
Y
T
N
L
G
D
F
E
V
E
L
Y
W
Y
H
S
P
K
T
C
L
N
F
Y
T
L
C
----------
E
---------------
M
G
F
-
Y
D
N
T
I
F
H
R
V
I
P
N
F
V
I
Q
G
G
D
P
T
-
G
-
T
G
K
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
Y
F
E
D
E
I
-
N
K
E
L
K
H
T
G
-
A
----
G
-
I
L
S
M
S
N
N
G
---
P
N
T
N
S
S
Q
F
F
I
T
L
A
P
---------------------------
L
P
H
L
D
G
K
H
T
I
F
A
R
V
S
K
--
N
-
M
T
C
I
E
N
I
A
S
V
Q
T
---
T
A
-
T
-------
N
-
K
P
I
F
D
L
K
I
L
R
T
S
T
--
230
HHSearch
84.36
44%
-22
- C8 -
-
4R3E
3
CWC27_HUMAN
A:
[9-170]
----------------
Q
E
P
P
T
N
G
K
-
V
L
L
K
T
T
A
G
D
I
D
I
E
L
W
S
K
E
A
P
K
A
C
R
N
F
I
Q
L
C
----------
L
---------------
E
A
Y
-
Y
D
N
T
I
F
H
R
V
V
P
G
F
I
V
Q
G
G
D
P
T
-
G
-
T
G
S
G
G
E
S
I
Y
-------------------------
G
-------------------------
A
P
F
K
D
E
F
-
H
S
R
L
R
F
N
R
-
R
----
G
-
L
V
A
M
A
N
A
G
---
S
H
D
N
G
S
Q
F
F
F
T
L
G
R
---------------------------
A
D
E
L
N
N
K
H
T
I
F
G
K
V
T
G
--
D
T
V
Y
N
M
L
R
L
S
E
V
D
I
---
D
D
-
D
-------
E
-
R
P
H
N
P
H
K
I
K
S
C
E
V
L
F
228
HHSearch
83.82
44%
-26
- C8 -
-
2POE
4
?
A:
[15-175]
--------------------
Y
F
Q
G
-
V
R
I
I
T
N
Y
G
D
L
K
F
E
L
F
C
S
Q
C
P
K
A
C
K
N
F
L
A
L
S
----------
A
---------------
S
G
Y
-
Y
K
N
T
I
F
H
K
N
I
K
G
F
I
I
Q
G
G
D
P
T
-
G
-
T
G
K
G
G
E
S
I
Y
-------------------------
G
-------------------------
R
Y
F
D
D
E
I
-
Y
P
E
L
K
Y
D
R
-
R
----
G
-
I
L
S
M
A
S
K
G
AKK
P
N
T
N
G
S
Q
F
F
I
T
Y
S
S
---------------------------
L
P
Q
L
N
G
E
Y
V
I
F
G
K
L
I
D
--
G
-
F
E
T
L
N
T
L
E
N
C
P
S
---
D
K
-
S
-------
H
-
K
P
I
D
E
I
I
I
K
D
I
V
I
H
S
6
PsiBlast_PDB
83.55
43%
-36
- C8 -
-
2OJU
-
PPIL3_HUMAN
A:
[6-160]
---------------------
G
M
S
-
V
T
L
H
T
D
V
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
L
A
L
C
----------
A
---------------
S
N
Y
-
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
D
P
T
-
G
-
T
G
R
G
G
N
S
I
W
-------------------------
G
-------------------------
K
K
F
E
D
E
Y
-
S
E
Y
L
K
H
N
V
-
R
----
G
-
V
V
S
M
A
N
N
G
---
P
N
T
N
G
S
Q
F
F
I
T
Y
---------------------------
G
K
Q
P
H
L
D
M
K
Y
T
V
F
G
K
V
I
D
--
G
-
L
E
T
L
D
E
L
E
K
L
P
V
---
N
E
-
K
-------
T
Y
R
P
L
N
D
V
H
I
K
D
I
T
I
--
3
PsiBlast_PDB
83.30
46%
-52
- C8 -
-
2X7K
-
PPIL1_HUMAN
A:
[8-159]
------------------
S
W
Q
P
P
N
-
V
Y
L
E
T
S
M
G
I
I
V
L
E
L
Y
W
K
H
A
P
K
T
C
K
N
F
A
E
L
A
----------
R
---------------
R
G
Y
-
Y
N
G
T
K
F
H
R
I
I
K
D
F
M
I
Q
G
G
D
P
T
-
G
-
T
G
R
G
G
A
S
I
Y
-------------------------
G
-------------------------
K
Q
F
E
D
E
L
-
H
P
D
L
K
F
T
G
-
A
----
G
-
I
L
A
M
A
N
A
G
---
P
D
T
N
G
S
Q
F
F
V
---
T
L
A
P
------------------------
T
Q
W
L
D
G
K
H
T
I
F
G
R
V
C
Q
--
G
-
I
G
M
V
N
R
V
G
M
V
E
T
---
N
S
-
Q
-------
D
-
R
P
V
D
D
V
K
I
-------
10
PsiBlast_PDB
82.47
43%
-50
- C8 -
-
2B71
-
?
A:
[27-186]
--------
I
A
Y
Y
K
M
K
-
G
H
T
E
R
G
-
Y
-
I
T
I
Y
T
N
L
G
D
F
E
V
E
L
Y
W
Y
H
S
P
K
T
C
L
N
F
Y
T
L
C
----------
E
---------------
M
G
F
-
Y
D
N
T
I
F
H
R
V
I
P
N
F
V
I
Q
G
G
D
P
T
-
G
-
T
G
K
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
Y
F
E
D
E
I
-
N
K
E
L
-
K
H
T
G
A
----
G
-
I
L
S
M
S
N
N
G
---
P
N
T
N
S
S
Q
F
F
I
T
---------
L
A
P
L
------------------
P
H
L
D
G
K
H
T
I
F
A
R
V
S
K
--
N
-
M
T
C
I
E
N
I
A
S
V
Q
T
---
T
A
-
T
-------
N
-
K
P
I
F
D
L
K
I
-------
229
HHSearch
81.84
46%
34
- C8 -
-
4R3F
10
?
A:
[9-199]
---------------N
L
E
P
Q
P
T
G
A
-
V
I
I
H
T
T
Q
G
D
L
K
V
E
L
F
A
K
Q
T
P
L
T
C
R
N
F
L
Q
H
S
----------
L
---------------
D
G
Y
-
Y
D
G
T
I
F
H
R
L
V
P
G
F
I
I
Q
G
G
D
P
T
-
G
-
T
G
H
G
G
E
S
I
Y
-------------------------
D
GGAFSGDLDPWPMDQRKGHNAGPMG
V
N
F
K
D
E
F
-
H
S
R
L
K
F
N
R
-
R
----
G
-
L
L
G
M
A
N
E
G
A--
P
D
T
N
G
S
Q
F
F
F
T
L
G
K
---------------------------
A
E
E
L
N
N
K
N
T
L
F
G
R
V
A
A
--
G
-
D
T
I
Y
N
L
M
K
W
G
E
A
ELI
E
G
-
T
-------
E
-
R
P
Q
Y
P
V
K
I
T
N
I
E
I
L
L
49
PsiBlast_CBE
81.68
37%
20
- C8 -
-
4R3F
10
?
A:
[9-197]
--------------
N
-
L
E
P
Q
P
T
G
A
-
V
I
I
H
T
T
Q
G
D
L
K
V
E
L
F
A
K
Q
T
P
L
T
C
R
N
F
L
Q
H
S
----------
L
---------------
D
G
Y
-
Y
D
G
T
I
F
H
R
L
V
P
G
F
I
I
Q
G
G
D
P
T
-
G
-
T
G
H
G
G
E
S
I
Y
DGGAFSGDLDPWPMDQRKGHNAGPM
G
-------------------------
V
N
F
K
D
E
F
H
S
R
L
K
-
F
N
R
-
R
----
G
-
L
L
G
M
A
N
E
G
A--
P
D
T
N
G
S
Q
F
F
F
T
---------
L
G
K
A
E
E
------------------
L
N
N
K
N
T
L
F
G
R
V
A
A
--
G
-----
D
T
I
Y
N
L
M
K
---
W
G
-
E
AELIEGT
E
-
R
P
Q
Y
P
V
K
I
T
N
I
E
I
--
9
PsiBlast_PDB
81.53
46%
-12
- C8 -
-
2FU0
-
?
A:
[5-159]
----------------------
P
K
S
A
I
I
Y
T
T
M
G
D
I
H
I
S
L
F
Y
K
E
C
K
K
T
V
Q
N
F
S
V
H
S
----------
I
---------------
N
G
Y
-
Y
N
N
C
I
F
H
R
V
I
K
H
F
M
V
Q
T
G
D
P
S
-
G
-
D
G
T
G
G
E
S
I
W
-------------------------
G
-------------------------
N
E
F
E
D
E
F
-
F
D
H
L
-
N
H
S
-
K
----
P
F
M
V
S
M
A
N
C
G
---
P
N
T
N
G
S
Q
F
F
I
---
T
T
V
P
C
------------------------
P
W
L
D
F
K
H
T
V
F
G
K
V
T
Q
--
G
-
S
K
I
V
L
D
I
E
K
V
R
T
---
D
K
-
R
-------
D
-
K
P
L
E
D
I
K
I
L
N
I
K
I
N
-
25
PsiBlast_CBE
74.12
47%
26
- C8 -
-
3EOV
1
?
B:
[26-166]
--------------------------------
G
R
I
T
I
G
L
F
G
K
D
A
P
L
T
T
E
N
F
R
Q
L
C
TG--------
E
---------------
H
G
F
G
Y
K
D
S
I
F
H
R
V
I
Q
N
F
M
I
Q
G
G
D
F
T
-
N
F
D
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
A
D
E
--
N
L
N
V
-
K
H
F
-
V
----
G
-
A
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
---
T
T
A
P
------------------------
T
P
W
L
D
G
R
H
V
V
F
G
K
V
L
D
--
G
-
M
D
V
V
L
R
I
E
K
T
K
T
---
N
S
-
H
-------
D
-
R
P
V
K
P
V
K
I
-------
26
PsiBlast_CBE
73.07
47%
17
- C8 -
-
3EOV
1
?
A:
[26-166]
--------------------------------
G
R
I
T
I
G
L
F
G
K
D
A
P
L
T
T
E
N
F
R
Q
L
C
T
G--------
E
---------------
H
G
F
G
Y
K
D
S
I
F
H
R
V
I
Q
N
F
M
I
Q
G
G
D
F
T
-
N
F
D
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
A
D
E
--
N
L
N
V
-
K
H
F
-
V
----
G
-
A
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
---
T
T
A
P
------------------------
T
P
W
L
D
G
R
H
V
V
F
G
K
V
L
D
--
G
-
M
D
V
V
L
R
I
E
K
T
K
T
---
N
S
-
H
-------
D
-
R
P
V
K
P
V
K
I
-------
40
PsiBlast_CBE
71.15
41%
30
- C8 -
-
1E8K
2
CYP3_CAEEL
A:
[18-165]
--------------------------------
G
R
I
V
M
E
L
Y
D
D
V
V
P
K
T
A
G
N
F
R
A
L
C
T
GENGIGKSG
K
---------------
P
L
H
-
F
K
G
S
K
F
H
R
I
I
P
N
F
M
I
Q
G
G
D
F
T
R
G
-
N
G
T
G
G
E
S
I
Y
-------------------------
G
-------------------------
E
K
F
P
D
E
N
-
F
K
E
K
-
H
T
G
-
P
----
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
L
C
T
V
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
R
V
V
E
--
G
-
L
D
V
V
K
A
V
E
S
--
N
---
G
S
-
Q
-------
S
G
K
P
V
K
D
C
M
I
-------
39
PsiBlast_CBE
71.02
41%
29
- C8 -
-
2IGV
1
CYP3_CAEEL
A:
[18-165]
--------------------------------
G
R
I
V
M
E
L
Y
D
D
V
V
P
K
T
A
G
N
F
R
A
L
C
T
GENGIGKSG
K
---------------
P
L
H
-
F
K
G
S
K
F
H
R
I
I
P
N
F
M
I
Q
G
G
D
F
T
R
G
-
N
G
T
G
G
E
S
I
Y
-------------------------
G
-------------------------
E
K
F
P
D
E
N
-
F
K
E
K
-
H
T
G
-
P
----
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
L
C
T
V
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
R
V
V
E
--
G
-
L
D
V
V
K
A
V
E
S
--
N
---
G
S
-
Q
-------
S
G
K
P
V
K
D
C
M
I
-------
41
PsiBlast_CBE
70.15
41%
29
- C8 -
-
1E3B
1
CYP3_CAEEL
A:
[18-165]
--------------------------------
G
R
I
V
M
E
L
Y
D
D
V
V
P
K
T
A
G
N
F
R
A
L
C
T
GENGIGKSG
K
---------------
P
L
H
-
F
K
G
S
K
F
H
R
I
I
P
N
F
M
I
Q
G
G
D
F
T
R
G
-
N
G
T
G
G
E
S
I
Y
-------------------------
G
-------------------------
E
K
F
P
D
E
N
-
F
K
E
K
-
H
T
G
-
P
----
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
L
C
T
V
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
R
V
V
E
--
G
-
L
D
V
V
K
A
V
E
S
--
N
---
G
S
-
Q
-------
S
G
K
P
V
K
D
C
M
I
-------
38
PsiBlast_CBE
69.68
41%
27
- C8 -
-
2IGW
2
CYP3_CAEEL
A:
[18-165]
--------------------------------
G
R
I
V
M
E
L
Y
D
D
V
V
P
K
T
A
G
N
F
R
A
L
C
T
GENGIGKSG
K
---------------
P
L
H
-
F
K
G
S
K
F
H
R
I
I
P
N
F
M
I
Q
G
G
D
F
T
R
G
-
N
G
T
G
G
E
S
I
Y
-------------------------
G
-------------------------
E
K
F
P
D
E
N
-
F
K
E
K
-
H
T
G
-
P
----
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
L
C
T
V
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
R
V
V
E
--
G
-
L
D
V
V
K
A
V
E
S
--
N
---
G
S
-
Q
-------
S
G
K
P
V
K
D
C
M
I
-------
45
PsiBlast_CBE
69.01
44%
3
- C8 -
-
1VDN
1
CYPH_YEAST
A:
[16-143]
--------------------------------
G
R
V
V
F
K
L
Y
N
D
I
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
A
G
S
P
F
H
R
V
I
P
D
F
M
L
Q
G
G
D
F
T
A
G
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
G
K
F
P
D
E
N
-
F
K
K
H
-
H
D
R
-
P
----
G
-
L
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
---
T
T
V
P
C
------------------------
P
W
L
D
G
K
H
V
V
F
G
E
V
V
D
--
G
-
Y
D
I
V
K
K
V
E
S
L
---------------------------------
56
PsiBlast_CBE
67.94
46%
-9
- C8 -
-
2CFE
3
?
A:
[16-140]
--------------------------------
G
T
I
K
F
K
L
F
D
D
V
V
P
K
T
A
A
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
A
G
S
H
F
H
R
V
I
P
D
F
M
L
Q
G
G
D
F
T
A
G
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
A
K
F
A
D
E
N
-
F
Q
L
K
-
H
N
K
-
P
----
G
-
L
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
T
T
V
V
---------------------------
T
S
W
L
D
G
K
H
V
V
F
G
E
V
I
D
--
G
-
M
N
V
V
K
A
I
------------------------------------
66
PsiBlast_CBE
66.53
44%
21
- C8 -
-
4N1M
2
PPIA_HUMAN
A:
[21-145]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
92
PsiBlast_CBE
65.89
44%
25
- C8 -
-
5NOZ
1
?
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
100
PsiBlast_CBE
65.66
44%
23
- C8 -
-
5NOR
2
?
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
96
PsiBlast_CBE
65.60
44%
22
- C8 -
-
5NOV
1
?
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
94
PsiBlast_CBE
65.39
44%
29
- C8 -
-
5NOX
1
?
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
71
PsiBlast_CBE
65.35
44%
23
- C8 -
-
5T9W
1
PPIA_HUMAN
A:
[17-141]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
98
PsiBlast_CBE
65.32
44%
27
- C8 -
-
5NOT
2
?
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
179
PsiBlast_CBE
65.10
44%
28
- C8 -
-
3RDD
1
PPIA_HUMAN
A:
[37-161]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
104
PsiBlast_CBE
64.70
44%
28
- C8 -
-
4N1R
1
PPIA_HUMAN
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
99
PsiBlast_CBE
64.65
44%
22
- C8 -
-
5NOS
1
?
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
161
PsiBlast_CBE
64.62
44%
24
- C8 -
-
1NMK
2
PPIA_HUMAN
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
95
PsiBlast_CBE
64.55
44%
31
- C8 -
-
5NOW
1
?
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
156
PsiBlast_CBE
64.33
44%
27
- C8 -
-
1W8L
1
PPIA_HUMAN
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
102
PsiBlast_CBE
64.28
44%
32
- C8 -
-
5LUD
1
PPIA_HUMAN
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
93
PsiBlast_CBE
64.18
44%
29
- C8 -
-
5NOY
1
?
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
160
PsiBlast_CBE
64.01
44%
20
- C8 -
-
1NMK
2
PPIA_HUMAN
B:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
TG--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
103
PsiBlast_CBE
63.96
44%
23
- C8 -
-
4N1S
2
PPIA_HUMAN
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
70
PsiBlast_CBE
63.93
44%
26
- C8 -
-
5TA4
1
PPIA_HUMAN
A:
[17-141]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
154
PsiBlast_CBE
63.88
44%
23
- C8 -
-
1YND
2
PPIA_HUMAN
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
101
PsiBlast_CBE
63.81
44%
28
- C8 -
-
5NOQ
2
?
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
107
PsiBlast_CBE
63.54
44%
26
- C8 -
-
4N1O
5
PPIA_HUMAN
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
106
PsiBlast_CBE
63.52
44%
29
- C8 -
-
4N1P
3
PPIA_HUMAN
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
108
PsiBlast_CBE
63.46
44%
24
- C8 -
-
4N1N
1
PPIA_HUMAN
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
97
PsiBlast_CBE
63.42
44%
25
- C8 -
-
5NOU
4
?
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
67
PsiBlast_CBE
63.32
44%
27
- C8 -
-
5TA2
1
PPIA_HUMAN
A:
[17-141]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
105
PsiBlast_CBE
63.28
44%
28
- C8 -
-
4N1Q
1
PPIA_HUMAN
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
64
PsiBlast_CBE
63.27
44%
26
- C8 -
-
5T9U
2
PPIA_HUMAN
B:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
68
PsiBlast_CBE
62.93
44%
23
- C8 -
-
5T9Z
1
PPIA_HUMAN
A:
[17-141]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
63
PsiBlast_CBE
62.90
44%
25
- C8 -
-
5T9U
2
PPIA_HUMAN
C:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
TG--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
203
PsiBlast_CBE
62.86
44%
46
- C8 -
-
4ZSD
1
PPIF_HUMAN
A:
[17-141]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
65
PsiBlast_CBE
62.51
44%
27
- C8 -
-
5T9U
2
PPIA_HUMAN
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
215
PsiBlast_CBE
62.38
44%
43
- C8 -
-
5CBV
4
PPIF_HUMAN
A:
[18-142]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
186
PsiBlast_CBE
62.35
44%
47
- C8 -
-
3RDC
1
PPIF_HUMAN
A:
[19-143]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
155
PsiBlast_CBE
62.34
44%
25
- C8 -
-
1W8M
1
PPIA_HUMAN
A:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
204
PsiBlast_CBE
62.26
44%
46
- C8 -
-
4ZSC
1
PPIF_HUMAN
A:
[17-141]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
193
PsiBlast_CBE
62.25
44%
45
- C8 -
-
3RCG
1
PPIF_HUMAN
A:
[19-143]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
197
PsiBlast_CBE
62.16
44%
43
- C8 -
-
3R56
2
PPIF_HUMAN
A:
[19-143]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
201
PsiBlast_CBE
62.14
44%
44
- C8 -
-
5CCQ
4
PPIF_HUMAN
A:
[17-141]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
210
PsiBlast_CBE
62.10
44%
43
- C8 -
-
4J5A
2
PPIF_HUMAN
X:
[17-141]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
TG--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
194
PsiBlast_CBE
61.92
44%
46
- C8 -
-
3RCF
2
PPIF_HUMAN
A:
[19-143]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
214
PsiBlast_CBE
61.80
44%
46
- C8 -
-
5CBW
4
PPIF_HUMAN
A:
[18-142]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
198
PsiBlast_CBE
61.78
44%
44
- C8 -
-
3R54
1
PPIF_HUMAN
A:
[19-143]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
187
PsiBlast_CBE
61.78
44%
48
- C8 -
-
3RDB
2
PPIF_HUMAN
A:
[19-143]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
153
PsiBlast_CBE
61.72
44%
29
- C8 -
-
1YND
2
PPIA_HUMAN
B:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
TG--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
200
PsiBlast_CBE
61.68
44%
44
- C8 -
-
3R49
2
PPIF_HUMAN
A:
[19-143]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
62
PsiBlast_CBE
61.67
44%
28
- C8 -
-
5T9U
2
PPIA_HUMAN
D:
[18-142]
--------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
TG--------
E
---------------
K
G
F
G
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
-
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
E
K
F
E
D
E
N
-
F
I
L
K
-
H
T
G
-
P
----
G
-
I
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
---------------------------
T
E
W
L
D
G
K
H
V
V
F
G
K
V
K
E
--
G
-
M
N
I
V
E
A
M
------------------------------------
207
PsiBlast_CBE
61.60
44%
42
- C8 -
-
4J5D
1
PPIF_HUMAN
X:
[17-141]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
TG--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
212
PsiBlast_CBE
61.59
44%
41
- C8 -
-
4J58
1
PPIF_HUMAN
A:
[17-141]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
191
PsiBlast_CBE
61.55
44%
47
- C8 -
-
3RCK
5
PPIF_HUMAN
X:
[19-143]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
TG--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
195
PsiBlast_CBE
61.51
44%
42
- C8 -
-
3R59
1
PPIF_HUMAN
A:
[19-143]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
185
PsiBlast_CBE
61.44
44%
45
- C8 -
-
2BIU
4
PPIF_HUMAN
X:
[18-142]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
TG--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
184
PsiBlast_CBE
61.44
44%
45
- C8 -
-
4O8H
2
PPIF_HUMAN
A:
[18-142]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
199
PsiBlast_CBE
61.42
44%
42
- C8 -
-
3R4G
5
PPIF_HUMAN
A:
[19-143]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
209
PsiBlast_CBE
61.40
44%
43
- C8 -
-
4J5B
1
PPIF_HUMAN
A:
[17-141]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
192
PsiBlast_CBE
61.40
44%
44
- C8 -
-
3RCI
4
PPIF_HUMAN
X:
[19-143]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
TG--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
202
PsiBlast_CBE
61.34
44%
45
- C8 -
-
5CCN
4
PPIF_HUMAN
A:
[17-141]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
205
PsiBlast_CBE
61.33
44%
43
- C8 -
-
4XNC
1
PPIF_HUMAN
A:
[17-141]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
196
PsiBlast_CBE
61.31
44%
45
- C8 -
-
3R57
5
PPIF_HUMAN
A:
[19-143]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
211
PsiBlast_CBE
61.30
44%
43
- C8 -
-
4J59
1
PPIF_HUMAN
A:
[17-141]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
213
PsiBlast_CBE
61.27
44%
47
- C8 -
-
5CCR
6
PPIF_HUMAN
A:
[18-142]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
216
PsiBlast_CBE
61.26
44%
47
* C8 *
-
5CBU
5
PPIF_HUMAN
A:
[18-142]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
208
PsiBlast_CBE
61.24
44%
45
- C8 -
-
4J5C
1
PPIF_HUMAN
X:
[17-141]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
TG--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
190
PsiBlast_CBE
61.13
44%
48
- C8 -
-
3RCL
2
PPIF_HUMAN
A:
[19-143]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
T
G--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
188
PsiBlast_CBE
60.91
44%
43
- C8 -
-
3RDA
7
PPIF_HUMAN
X:
[19-143]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
TG--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------
206
PsiBlast_CBE
60.67
44%
48
- C8 -
-
4J5E
1
PPIF_HUMAN
X:
[17-141]
--------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
TG--------
E
---------------
K
G
F
G
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
H
N
G
T
G
G
K
S
I
Y
-------------------------
G
-------------------------
S
R
F
P
D
E
-----
N
-
F
T
L
-
K
HVGP
G
-
V
L
S
M
A
N
A
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
I
K
---------------------------
T
D
W
L
D
G
K
H
V
V
F
G
H
V
I
E
--
G
-
M
D
V
V
K
K
I
------------------------------------