@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1289: (2016-03-24 )
MSKYSQDVLQLLYKNKPNYISGQSIAESLNISRTAVKKVIDQLKLEGCKIDSVNHKGHLLQQLPDIWYQGIIDQYTKSSALFDFSEVYDSIDSTQLAAKKSLVGNQSSFFILSDEQTKGRGRFNRHWSSSKGQGLWMSVVLRPNVAFSMISKFNLFIALGIRDAIQHFSQDEVKVKWPNDIYIDNGKVCGFLTEMVANNDGIEAIICGIGINLTQQLENFDESIRHRATSIQLHDKNKLDRYQFLERLLQEIEKRYNQFLTLPFSEIREEYIAASNIWNRTLLFTENDKQFKGQAIDLDYDGYLIVRDEAGESHRLISADIDF
Atome Classification :
(29 SA)
.........10........20........30........40........50........60........70........80..-......90........100.......110.......120.......130.......140.......150.......160.......170.......180...----....190.......200.......210.......220.......230.......240.......250.......260--.---......270.......280......-.290.......300.......310.......320.---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
K
Y
S
Q
D
V
L
Q
L
L
YKNKPNYIS
G
Q
S
I
A
E
S
LNI
S
R
T
A
V
K
K
V
I
D
Q
LKLEGCKIDSVNHK
G
H
L
L
Q
Q
L
P
D
I
W
Y
Q
G
I
I
D
Q
YTKSSAL
F
D
-
F
S
E
V
Y
D
SI
D
S
T
Q
L
A
A
K
K
S
LVGNQ
S
S
F
F
I
L
SDEQTKGRGRFNRHWSSSKGQ
G
L
W
M
S
V
V
LRP
N
V
A
F
S
M
I
S
KF
N
L
F
I
A
LG
I
R
D
A
I
Q
HFSQD
E
V
K
V
KWP
N
D
I
Y
IDN----G
K
V
C
G
F
L
T
E
M
V
ANNDG
I
E
A
I
I
CGIG
I
N
L
T
Q
Q
L
E
N
F
D
E
S
I
R
HRA
T
S
I
Q
LHDKNK
L
D
R
Y
Q
F
L
E
R
L
L
Q
E
I
E
K
R
Y
N
Q
F
L
TL--
P
---
F
S
E
I
R
E
E
Y
I
A
A
SNIWN
R
T
L
L
F
TEND-KQFKG
Q
A
I
D
LDYD
G
Y
L
I
V
RDEAGESH
R
L
I
SADIDF---
11
PsiBlast_PDB
89.48
100%
-117
- C2 -
4DQ2
1
?
A:
[1-322]
-
S
K
Y
S
Q
D
V
L
Q
L
L
Y
K
N
K
P
N
Y
I
S
G
Q
S
I
A
E
S
L
N
I
S
R
T
A
V
K
K
V
I
D
Q
L
K
L
E
G
C
K
I
D
S
V
N
H
K
G
H
L
L
Q
Q
L
P
D
I
W
Y
Q
G
I
I
D
Q
Y
T
K
S
S
A
L
F
D
-
F
S
E
V
Y
D
S
I
D
S
T
Q
L
A
A
K
K
S
L
V
G
N
Q
S
S
F
F
I
L
S
D
E
Q
T
K
G
R
G
R
F
N
R
H
W
S
S
S
K
G
Q
G
L
W
M
S
V
V
L
R
P
N
V
A
F
S
M
I
S
K
F
N
L
F
I
A
L
G
I
R
D
A
I
Q
H
F
S
Q
D
E
V
K
V
K
W
P
N
D
I
Y
I
D
N
----
G
K
V
C
G
F
L
T
E
M
V
A
N
N
D
G
I
E
A
I
I
C
G
I
G
I
N
L
T
Q
Q
L
E
N
F
D
E
S
I
R
H
R
A
T
S
I
Q
L
H
D
K
N
K
L
D
R
Y
Q
F
L
E
R
L
L
Q
E
I
E
K
R
Y
N
Q
F
L
T
L
--
P
---
F
S
E
I
R
E
E
Y
I
A
A
S
N
I
W
N
R
T
L
L
F
T
E
N
D
-
K
Q
F
K
G
Q
A
I
D
L
D
Y
D
G
Y
L
I
V
R
D
E
A
G
E
S
H
R
L
I
S
A
D
I
D
F
---
5
PsiBlast_PDB
88.97
100%
-120
- C2 -
3V8K
1
?
A:
[8-329]
-
S
K
Y
S
Q
D
V
L
Q
L
L
Y
K
N
K
P
N
Y
I
S
G
Q
S
I
A
E
S
L
N
I
S
R
T
A
V
K
K
V
I
D
Q
L
K
L
E
G
C
K
I
D
S
V
N
H
K
G
H
L
L
Q
Q
L
P
D
I
W
Y
Q
G
I
I
D
Q
Y
T
K
S
S
A
L
F
D
-
F
S
E
V
Y
D
S
I
D
S
T
Q
L
A
A
K
K
S
L
V
G
N
Q
S
S
F
F
I
L
S
D
E
Q
T
K
G
R
G
R
F
N
R
H
W
S
S
S
K
G
Q
G
L
W
M
S
V
V
L
R
P
N
V
A
F
S
M
I
S
K
F
N
L
F
I
A
L
G
I
R
D
A
I
Q
H
F
S
Q
D
E
V
K
V
K
W
P
N
D
I
Y
I
D
N
----
G
K
V
C
G
F
L
T
E
M
V
A
N
N
D
G
I
E
A
I
I
C
G
I
G
I
N
L
T
Q
Q
L
E
N
F
D
E
S
I
R
H
R
A
T
S
I
Q
L
H
D
K
N
K
L
D
R
Y
Q
F
L
E
R
L
L
Q
E
I
E
K
R
Y
N
Q
F
L
T
L
--
P
---
F
S
E
I
R
E
E
Y
I
A
A
S
N
I
W
N
R
T
L
L
F
T
E
N
D
-
K
Q
F
K
G
Q
A
I
D
L
D
Y
D
G
Y
L
I
V
R
D
E
A
G
E
S
H
R
L
I
S
A
D
I
D
F
---
12
PsiBlast_PDB
88.88
99%
-116
- C2 -
4HA8
1
?
A:
[7-328]
-
S
K
Y
S
Q
D
V
L
Q
L
L
Y
K
N
K
P
N
Y
I
S
G
Q
S
I
A
E
S
L
N
I
S
R
T
A
V
K
K
V
I
D
Q
L
K
L
E
G
C
K
I
D
S
V
N
H
K
G
H
L
L
Q
Q
L
P
D
I
W
Y
Q
G
I
I
D
Q
Y
T
K
S
S
A
L
F
D
-
F
S
E
V
Y
D
S
I
D
S
T
Q
L
A
A
K
K
S
L
V
G
N
Q
S
S
F
F
I
L
S
D
E
Q
T
K
G
R
G
R
F
N
R
H
W
S
S
S
K
G
Q
G
L
W
M
S
V
V
L
R
P
N
V
A
F
S
M
I
S
K
F
N
L
F
I
A
L
G
I
R
D
A
I
Q
H
F
S
Q
D
E
V
K
V
K
W
P
N
D
I
Y
I
D
N
----
G
K
V
C
G
F
L
T
E
M
V
A
N
N
D
G
I
E
A
I
I
C
G
I
G
I
N
L
T
Q
Q
L
E
N
F
D
E
S
I
R
H
R
A
T
S
I
Q
L
H
D
K
N
K
L
D
R
Y
Q
F
L
E
R
L
L
Q
E
I
E
K
R
Y
N
Q
F
L
T
L
--
P
---
F
S
E
I
R
E
E
Y
N
A
A
S
N
I
W
N
R
T
L
L
F
T
E
N
D
-
K
Q
F
K
G
Q
A
I
D
L
D
Y
D
G
Y
L
I
V
R
D
E
A
G
E
S
H
R
L
I
S
A
D
I
D
F
---
1
PsiBlast_PDB
88.87
100%
-118
* C2 *
3V7C
1
?
A:
[2-323]
-
S
K
Y
S
Q
D
V
L
Q
L
L
Y
K
N
K
P
N
Y
I
S
G
Q
S
I
A
E
S
L
N
I
S
R
T
A
V
K
K
V
I
D
Q
L
K
L
E
G
C
K
I
D
S
V
N
H
K
G
H
L
L
Q
Q
L
P
D
I
W
Y
Q
G
I
I
D
Q
Y
T
K
S
S
A
L
F
D
-
F
S
E
V
Y
D
S
I
D
S
T
Q
L
A
A
K
K
S
L
V
G
N
Q
S
S
F
F
I
L
S
D
E
Q
T
K
G
R
G
R
F
N
R
H
W
S
S
S
K
G
Q
G
L
W
M
S
V
V
L
R
P
N
V
A
F
S
M
I
S
K
F
N
L
F
I
A
L
G
I
R
D
A
I
Q
H
F
S
Q
D
E
V
K
V
K
W
P
N
D
I
Y
I
D
N
----
G
K
V
C
G
F
L
T
E
M
V
A
N
N
D
G
I
E
A
I
I
C
G
I
G
I
N
L
T
Q
Q
L
E
N
F
D
E
S
I
R
H
R
A
T
S
I
Q
L
H
D
K
N
K
L
D
R
Y
Q
F
L
E
R
L
L
Q
E
I
E
K
R
Y
N
Q
F
L
T
L
--
P
---
F
S
E
I
R
E
E
Y
I
A
A
S
N
I
W
N
R
T
L
L
F
T
E
N
D
-
K
Q
F
K
G
Q
A
I
D
L
D
Y
D
G
Y
L
I
V
R
D
E
A
G
E
S
H
R
L
I
S
A
D
I
D
F
---
3
PsiBlast_PDB
88.73
100%
-116
- C2 -
3V7R
1
?
A:
[8-329]
-
S
K
Y
S
Q
D
V
L
Q
L
L
Y
K
N
K
P
N
Y
I
S
G
Q
S
I
A
E
S
L
N
I
S
R
T
A
V
K
K
V
I
D
Q
L
K
L
E
G
C
K
I
D
S
V
N
H
K
G
H
L
L
Q
Q
L
P
D
I
W
Y
Q
G
I
I
D
Q
Y
T
K
S
S
A
L
F
D
-
F
S
E
V
Y
D
S
I
D
S
T
Q
L
A
A
K
K
S
L
V
G
N
Q
S
S
F
F
I
L
S
D
E
Q
T
K
G
R
G
R
F
N
R
H
W
S
S
S
K
G
Q
G
L
W
M
S
V
V
L
R
P
N
V
A
F
S
M
I
S
K
F
N
L
F
I
A
L
G
I
R
D
A
I
Q
H
F
S
Q
D
E
V
K
V
K
W
P
N
D
I
Y
I
D
N
----
G
K
V
C
G
F
L
T
E
M
V
A
N
N
D
G
I
E
A
I
I
C
G
I
G
I
N
L
T
Q
Q
L
E
N
F
D
E
S
I
R
H
R
A
T
S
I
Q
L
H
D
K
N
K
L
D
R
Y
Q
F
L
E
R
L
L
Q
E
I
E
K
R
Y
N
Q
F
L
T
L
--
P
---
F
S
E
I
R
E
E
Y
I
A
A
S
N
I
W
N
R
T
L
L
F
T
E
N
D
-
K
Q
F
K
G
Q
A
I
D
L
D
Y
D
G
Y
L
I
V
R
D
E
A
G
E
S
H
R
L
I
S
A
D
I
D
F
---
8
PsiBlast_PDB
88.61
99%
-120
- C2 -
3RKW
1
?
A:
[2-323]
-
S
K
Y
S
Q
D
V
L
Q
L
L
Y
K
N
K
P
N
Y
I
S
G
Q
S
I
A
E
S
L
N
I
S
R
T
A
V
K
K
V
I
D
Q
L
K
L
E
G
C
K
I
D
S
V
N
H
K
G
H
L
L
Q
Q
L
P
D
I
W
Y
Q
G
I
I
D
Q
Y
T
K
S
S
A
L
F
D
-
F
S
E
V
Y
D
S
I
D
S
T
Q
L
A
A
K
K
S
L
V
G
N
Q
S
S
F
F
I
L
S
D
E
Q
T
K
G
R
G
R
F
N
R
H
W
S
S
S
K
G
Q
G
L
W
M
S
V
V
L
R
P
N
V
A
F
S
M
I
S
K
F
N
L
F
I
A
L
G
I
R
D
A
I
Q
H
F
S
Q
D
E
V
K
V
K
W
P
N
D
I
Y
I
D
N
----
G
K
V
C
G
F
L
T
E
M
V
A
N
N
D
G
I
E
A
I
I
C
G
I
G
I
N
L
T
Q
Q
L
E
N
F
D
E
S
I
R
H
R
A
T
S
I
Q
L
H
D
K
N
K
L
D
R
Y
Q
F
L
E
R
L
L
Q
E
I
E
K
R
Y
N
Q
F
L
T
L
--
P
---
F
S
E
I
R
E
E
Y
N
A
A
S
N
I
W
N
R
T
L
L
F
T
E
N
D
-
K
Q
F
K
G
Q
A
I
D
L
D
Y
D
G
Y
L
I
V
R
D
E
A
G
E
S
H
R
L
I
S
A
D
I
D
F
---
6
PsiBlast_PDB
88.37
100%
-117
- C2 -
3V8L
1
?
A:
[8-329]
-
S
K
Y
S
Q
D
V
L
Q
L
L
Y
K
N
K
P
N
Y
I
S
G
Q
S
I
A
E
S
L
N
I
S
R
T
A
V
K
K
V
I
D
Q
L
K
L
E
G
C
K
I
D
S
V
N
H
K
G
H
L
L
Q
Q
L
P
D
I
W
Y
Q
G
I
I
D
Q
Y
T
K
S
S
A
L
F
D
-
F
S
E
V
Y
D
S
I
D
S
T
Q
L
A
A
K
K
S
L
V
G
N
Q
S
S
F
F
I
L
S
D
E
Q
T
K
G
R
G
R
F
N
R
H
W
S
S
S
K
G
Q
G
L
W
M
S
V
V
L
R
P
N
V
A
F
S
M
I
S
K
F
N
L
F
I
A
L
G
I
R
D
A
I
Q
H
F
S
Q
D
E
V
K
V
K
W
P
N
D
I
Y
I
D
N
----
G
K
V
C
G
F
L
T
E
M
V
A
N
N
D
G
I
E
A
I
I
C
G
I
G
I
N
L
T
Q
Q
L
E
N
F
D
E
S
I
R
H
R
A
T
S
I
Q
L
H
D
K
N
K
L
D
R
Y
Q
F
L
E
R
L
L
Q
E
I
E
K
R
Y
N
Q
F
L
T
L
--
P
---
F
S
E
I
R
E
E
Y
I
A
A
S
N
I
W
N
R
T
L
L
F
T
E
N
D
-
K
Q
F
K
G
Q
A
I
D
L
D
Y
D
G
Y
L
I
V
R
D
E
A
G
E
S
H
R
L
I
S
A
D
I
D
F
---
10
PsiBlast_PDB
88.20
99%
-119
- C2 -
3RKY
1
?
A:
[2-323]
-
S
K
Y
S
Q
D
V
L
Q
L
L
Y
K
N
K
P
N
Y
I
S
G
Q
S
I
A
E
S
L
N
I
S
R
T
A
V
K
K
V
I
D
Q
L
K
L
E
G
C
K
I
D
S
V
N
H
K
G
H
L
L
Q
Q
L
P
D
I
W
Y
Q
G
I
I
D
Q
Y
T
K
S
S
A
L
F
D
-
F
S
E
V
Y
D
S
I
D
S
T
Q
L
A
A
K
K
S
L
V
G
N
Q
S
S
F
F
I
L
S
D
E
Q
T
K
G
R
G
R
F
N
R
H
W
S
S
S
K
G
Q
G
L
W
M
S
V
V
L
R
P
N
V
A
F
S
M
I
S
K
F
N
L
F
I
A
L
G
I
R
D
A
I
Q
H
F
S
Q
D
E
V
K
V
K
W
P
N
D
I
Y
I
D
N
----
G
K
V
C
G
F
L
T
E
M
V
A
N
N
D
G
I
E
A
I
I
C
G
I
G
I
N
L
T
Q
Q
L
E
N
F
D
E
S
I
R
H
R
A
T
S
I
Q
L
H
D
K
N
K
L
D
R
Y
Q
F
L
E
R
L
L
Q
E
I
E
K
R
Y
N
Q
F
L
T
L
--
P
---
F
S
E
I
R
E
E
Y
N
A
A
S
N
I
W
N
R
T
L
L
F
T
E
N
D
-
K
Q
F
K
G
Q
A
I
D
L
D
Y
D
G
Y
L
I
V
R
D
E
A
G
E
S
H
R
L
I
S
A
D
I
D
F
---
7
PsiBlast_PDB
88.19
99%
-116
- C2 -
3RIR
1
?
A:
[2-323]
-
S
K
Y
S
Q
D
V
L
Q
L
L
Y
K
N
K
P
N
Y
I
S
G
Q
S
I
A
E
S
L
N
I
S
R
T
A
V
K
K
V
I
D
Q
L
K
L
E
G
C
K
I
D
S
V
N
H
K
G
H
L
L
Q
Q
L
P
D
I
W
Y
Q
G
I
I
D
Q
Y
T
K
S
S
A
L
F
D
-
F
S
E
V
Y
D
S
I
D
S
T
Q
L
A
A
K
K
S
L
V
G
N
Q
S
S
F
F
I
L
S
D
E
Q
T
K
G
R
G
R
F
N
R
H
W
S
S
S
K
G
Q
G
L
W
M
S
V
V
L
R
P
N
V
A
F
S
M
I
S
K
F
N
L
F
I
A
L
G
I
R
D
A
I
Q
H
F
S
Q
D
E
V
K
V
K
W
P
N
D
I
Y
I
D
N
----
G
K
V
C
G
F
L
T
E
M
V
A
N
N
D
G
I
E
A
I
I
C
G
I
G
I
N
L
T
Q
Q
L
E
N
F
D
E
S
I
R
H
R
A
T
S
I
Q
L
H
D
K
N
K
L
D
R
Y
Q
F
L
E
R
L
L
Q
E
I
E
K
R
Y
N
Q
F
L
T
L
--
P
---
F
S
E
I
R
E
E
Y
N
A
A
S
N
I
W
N
R
T
L
L
F
T
E
N
D
-
K
Q
F
K
G
Q
A
I
D
L
D
Y
D
G
Y
L
I
V
R
D
E
A
G
E
S
H
R
L
I
S
A
D
I
D
F
---
2
PsiBlast_PDB
88.10
100%
-118
- C2 -
3V7S
1
?
A:
[2-323]
-
S
K
Y
S
Q
D
V
L
Q
L
L
Y
K
N
K
P
N
Y
I
S
G
Q
S
I
A
E
S
L
N
I
S
R
T
A
V
K
K
V
I
D
Q
L
K
L
E
G
C
K
I
D
S
V
N
H
K
G
H
L
L
Q
Q
L
P
D
I
W
Y
Q
G
I
I
D
Q
Y
T
K
S
S
A
L
F
D
-
F
S
E
V
Y
D
S
I
D
S
T
Q
L
A
A
K
K
S
L
V
G
N
Q
S
S
F
F
I
L
S
D
E
Q
T
K
G
R
G
R
F
N
R
H
W
S
S
S
K
G
Q
G
L
W
M
S
V
V
L
R
P
N
V
A
F
S
M
I
S
K
F
N
L
F
I
A
L
G
I
R
D
A
I
Q
H
F
S
Q
D
E
V
K
V
K
W
P
N
D
I
Y
I
D
N
----
G
K
V
C
G
F
L
T
E
M
V
A
N
N
D
G
I
E
A
I
I
C
G
I
G
I
N
L
T
Q
Q
L
E
N
F
D
E
S
I
R
H
R
A
T
S
I
Q
L
H
D
K
N
K
L
D
R
Y
Q
F
L
E
R
L
L
Q
E
I
E
K
R
Y
N
Q
F
L
T
L
--
P
---
F
S
E
I
R
E
E
Y
I
A
A
S
N
I
W
N
R
T
L
L
F
T
E
N
D
-
K
Q
F
K
G
Q
A
I
D
L
D
Y
D
G
Y
L
I
V
R
D
E
A
G
E
S
H
R
L
I
S
A
D
I
D
F
---
4
PsiBlast_PDB
87.77
100%
-130
- C2 -
3V8J
-
?
A:
[1-322]
-
S
K
Y
S
Q
D
V
L
Q
L
L
Y
K
N
K
P
N
Y
I
S
G
Q
S
I
A
E
S
L
N
I
S
R
T
A
V
K
K
V
I
D
Q
L
K
L
E
G
C
K
I
D
S
V
N
H
K
G
H
L
L
Q
Q
L
P
D
I
W
Y
Q
G
I
I
D
Q
Y
T
K
S
S
A
L
F
D
-
F
S
E
V
Y
D
S
I
D
S
T
Q
L
A
A
K
K
S
L
V
G
N
Q
S
S
F
F
I
L
S
D
E
Q
---------------
G
Q
G
L
W
M
S
V
V
L
R
P
N
V
A
F
S
M
I
S
K
F
N
L
F
I
A
L
G
I
R
D
A
I
Q
H
F
S
Q
D
E
V
K
V
K
W
P
N
D
I
Y
I
D
N
----
G
K
V
C
G
F
L
T
E
M
V
A
N
N
D
G
I
E
A
I
I
C
G
I
G
I
N
L
T
Q
Q
L
E
N
F
D
E
S
I
R
H
R
A
T
S
I
Q
L
H
D
K
N
K
L
D
R
Y
Q
F
L
E
R
L
L
Q
E
I
E
K
R
Y
N
Q
F
L
T
L
--
P
---
F
S
E
I
R
E
E
Y
I
A
A
S
N
I
W
N
R
T
L
L
F
T
E
N
--
K
Q
F
K
G
Q
A
I
D
L
D
Y
D
G
Y
L
I
V
R
D
E
A
G
E
S
H
R
L
I
S
A
D
I
D
F
---
35
HHSearch
87.71
100%
-130
- C2 -
3RKX
-
?
A:
[3-323]
--
K
Y
S
Q
D
V
L
Q
L
L
Y
K
N
K
P
N
Y
I
S
G
Q
S
I
A
E
S
L
N
I
S
R
T
A
V
K
K
V
I
D
Q
L
K
L
E
G
C
K
I
D
S
V
N
H
K
G
H
L
L
Q
Q
L
P
D
I
W
Y
Q
G
I
I
D
Q
Y
T
K
S
S
A
L
F
D
-
F
S
E
V
Y
D
S
I
D
S
T
Q
L
A
A
K
K
S
L
V
G
N
Q
S
S
F
F
I
L
S
D
E
Q
T
------------
S
K
G
Q
G
L
W
M
S
V
V
L
R
P
N
V
A
F
S
M
I
S
K
F
N
L
F
I
A
L
G
I
R
D
A
I
Q
H
F
S
Q
D
E
V
K
V
K
W
P
N
D
I
Y
I
D
N
----
G
K
V
C
G
F
L
T
E
M
V
A
N
N
D
G
I
E
A
I
I
C
G
I
G
I
N
L
T
Q
Q
L
E
N
F
D
E
S
I
R
H
R
A
T
S
I
Q
L
H
D
K
N
K
L
D
R
Y
Q
F
L
E
R
L
L
Q
E
I
E
K
R
Y
N
Q
F
L
T
L
--
P
---
F
S
E
I
R
E
E
Y
N
A
A
S
N
I
W
N
R
T
L
L
F
T
E
N
--
K
Q
F
K
G
Q
A
I
D
L
D
Y
D
G
Y
L
I
V
R
D
E
A
G
E
S
H
R
L
I
S
A
D
I
D
F
---
56
Fugue
87.53
99%
-130
- C2 -
3RKX
-
?
A:
[3-323]
--
K
Y
S
Q
D
V
L
Q
L
L
Y
K
N
K
P
N
Y
I
S
G
Q
S
I
A
E
S
L
N
I
S
R
T
A
V
K
K
V
I
D
Q
L
K
L
E
G
C
K
I
D
S
V
N
H
K
G
H
L
L
Q
Q
L
P
D
I
W
Y
Q
G
I
I
D
Q
Y
T
K
S
S
A
L
F
D
-
F
S
E
V
Y
D
S
I
D
S
T
Q
L
A
A
K
K
S
L
V
G
N
Q
S
S
F
F
I
L
S
D
E
Q
T
------------
S
K
G
Q
G
L
W
M
S
V
V
L
R
P
N
V
A
F
S
M
I
S
K
F
N
L
F
I
A
L
G
I
R
D
A
I
Q
H
F
S
Q
D
E
V
K
V
K
W
P
N
D
I
Y
I
D
N
----
G
K
V
C
G
F
L
T
E
M
V
A
N
N
D
G
I
E
A
I
I
C
G
I
G
I
N
L
T
Q
Q
L
E
N
F
D
E
S
I
R
H
R
A
T
S
I
Q
L
H
D
K
N
K
L
D
R
Y
Q
F
L
E
R
L
L
Q
E
I
E
K
R
Y
N
Q
F
L
T
L
--
P
---
F
S
E
I
R
E
E
Y
N
A
A
S
N
I
W
N
R
T
L
L
F
T
E
N
K
--
Q
F
K
G
Q
A
I
D
L
D
Y
D
G
Y
L
I
V
R
D
E
A
G
E
S
H
R
L
I
S
A
D
I
D
F
---
9
PsiBlast_PDB
87.52
99%
-130
- C2 -
3RKX
-
?
A:
[3-323]
--
K
Y
S
Q
D
V
L
Q
L
L
Y
K
N
K
P
N
Y
I
S
G
Q
S
I
A
E
S
L
N
I
S
R
T
A
V
K
K
V
I
D
Q
L
K
L
E
G
C
K
I
D
S
V
N
H
K
G
H
L
L
Q
Q
L
P
D
I
W
Y
Q
G
I
I
D
Q
Y
T
K
S
S
A
L
F
D
-
F
S
E
V
Y
D
S
I
D
S
T
Q
L
A
A
K
K
S
L
V
G
N
Q
S
S
F
F
I
L
S
D
E
Q
T
------------
S
K
G
Q
G
L
W
M
S
V
V
L
R
P
N
V
A
F
S
M
I
S
K
F
N
L
F
I
A
L
G
I
R
D
A
I
Q
H
F
S
Q
D
E
V
K
V
K
W
P
N
D
I
Y
I
D
N
----
G
K
V
C
G
F
L
T
E
M
V
A
N
N
D
G
I
E
A
I
I
C
G
I
G
I
N
L
T
Q
Q
L
E
N
F
D
E
S
I
R
H
R
A
T
S
I
Q
L
H
D
K
N
K
L
D
R
Y
Q
F
L
E
R
L
L
Q
E
I
E
K
R
Y
N
Q
F
L
T
L
--
P
---
F
S
E
I
R
E
E
Y
N
A
A
S
N
I
W
N
R
T
L
L
F
T
E
N
--
K
Q
F
K
G
Q
A
I
D
L
D
Y
D
G
Y
L
I
V
R
D
E
A
G
E
S
H
R
L
I
S
A
D
I
D
F
---
36
HHSearch
57.69
24%
-93
- C2 -
1BIA
-
BIRA_ECOLI
A:
[4-316]
-
N
T
V
P
L
K
L
I
A
L
L
A
N
G
--
E
F
H
S
G
E
Q
L
G
E
T
L
G
M
S
R
A
A
I
N
K
H
I
Q
T
L
R
D
W
G
V
D
V
F
T
V
P
G
K
G
Y
S
L
P
E
P
I
Q
L
L
N
A
K
Q
I
L
G
Q
L
D
-----
G
G
S
V
A
V
L
P
V
I
D
S
T
N
Q
Y
L
L
D
R
I
G
E
L
K
S
G
D
A
C
I
A
E
Y
Q
Q
A
G
---------
S
P
F
G
A
N
L
Y
L
S
M
F
W
R
L
E
Q
-
P
A
A
A
I
G
L
S
L
V
I
G
I
V
M
A
E
V
L
R
K
L
G
A
D
K
V
R
V
K
W
P
N
D
L
Y
L
Q
D
----
R
K
L
A
G
I
L
V
E
L
T
G
----
A
A
Q
I
V
I
G
A
G
I
N
M
A
M
------------
W
I
T
L
Q
E
A
G
-
I
N
L
D
R
N
T
L
A
A
M
L
I
R
E
L
R
A
A
L
E
L
F
E
Q
E
--
G
---
L
A
P
Y
L
S
R
W
E
K
L
D
N
F
I
N
R
P
V
K
L
I
I
G
D
-
K
E
I
F
G
I
S
R
G
I
D
K
Q
G
A
L
L
L
E
Q
-
D
G
I
I
K
P
W
M
G
G
E
I
S
L
---
57
Fugue
53.73
31%
-85
- C2 -
1WNL
2
?
A:
[1-235]
------------------------------------------------------------------------
M
L
G
L
K
T
S
I
I
G
R
-
R
V
I
Y
F
Q
E
I
T
S
T
N
E
F
A
K
T
S
--
Y
L
E
E
G
T
V
I
V
A
D
K
Q
T
M
G
H
G
R
L
N
R
K
W
E
S
P
E
G
-
G
L
W
L
S
I
V
L
S
P
K
V
P
Q
K
D
L
P
K
I
V
F
L
G
A
V
G
V
V
E
T
L
K
E
F
S
I
D
-
G
R
I
K
W
P
N
D
V
L
V
N
Y
----
K
K
I
A
G
V
L
V
E
G
K
G
D
-----
K
I
V
L
G
I
G
L
N
V
N
N
K
V
P
N
-------
G
A
T
S
M
K
L
E
L
G
S
E
V
P
L
L
S
V
F
R
S
L
I
T
N
L
D
R
L
Y
L
N
F
L
K
N
--
P
---
M
D
I
L
N
L
V
R
D
N
---
M
I
L
G
V
R
V
K
I
L
G
D
-
G
S
F
E
G
I
A
E
D
I
D
D
F
G
R
L
I
I
R
L
D
S
G
E
V
K
K
V
I
Y
G
D
V
S
L
R
F
L
16
PsiBlast_PDB
52.76
30%
-93
- C2 -
1X01
1
?
A:
[16-232]
----------------------------------------------------------------------------------------
F
Q
E
I
T
S
T
N
E
F
A
K
T
S
Y
L
--
E
E
G
T
V
I
V
A
D
K
Q
T
M
G
H
G
R
L
N
R
K
W
E
S
P
E
G
-
G
L
W
L
S
I
V
L
S
P
K
V
P
Q
K
D
L
P
K
I
V
F
L
G
A
V
G
V
V
E
T
L
K
E
F
S
I
D
G
-
R
I
K
W
P
N
D
V
L
V
N
Y
----
K
K
I
A
G
V
L
V
E
G
K
G
-----
D
K
I
V
L
G
I
G
L
N
V
N
N
K
V
P
N
-------
G
A
T
S
M
K
L
E
L
G
S
E
V
P
L
L
S
V
F
R
S
L
I
T
N
L
D
R
L
Y
L
N
F
L
K
N
--
P
M
D
I
L
N
L
V
R
D
N
M
I
L
G
V
R
V
--
K
I
L
----
G
D
-
G
S
F
E
G
I
A
E
D
I
D
D
F
G
R
L
I
I
R
L
D
S
G
E
V
K
K
V
I
Y
G
D
V
S
L
---
13
PsiBlast_PDB
52.17
30%
-93
- C2 -
1WNL
2
?
A:
[16-232]
----------------------------------------------------------------------------------------
F
Q
E
I
T
S
T
N
E
F
A
K
T
S
Y
L
--
E
E
G
T
V
I
V
A
D
K
Q
T
M
G
H
G
R
L
N
R
K
W
E
S
P
E
G
-
G
L
W
L
S
I
V
L
S
P
K
V
P
Q
K
D
L
P
K
I
V
F
L
G
A
V
G
V
V
E
T
L
K
E
F
S
I
D
G
-
R
I
K
W
P
N
D
V
L
V
N
Y
----
K
K
I
A
G
V
L
V
E
G
K
G
-----
D
K
I
V
L
G
I
G
L
N
V
N
N
K
V
P
N
-------
G
A
T
S
M
K
L
E
L
G
S
E
V
P
L
L
S
V
F
R
S
L
I
T
N
L
D
R
L
Y
L
N
F
L
K
N
--
P
M
D
I
L
N
L
V
R
D
N
M
I
L
G
V
R
V
--
K
I
L
----
G
D
-
G
S
F
E
G
I
A
E
D
I
D
D
F
G
R
L
I
I
R
L
D
S
G
E
V
K
K
V
I
Y
G
D
V
S
L
---
39
HHSearch
51.73
29%
-89
- C2 -
2EJ9
1
BPL_METJA
A:
[2-235]
------------------------------------------------------------------------------------
E
I
I
H
L
S
E
I
D
S
T
N
D
Y
A
K
E
L
A
K
E
G
K
R
N
F
I
V
L
A
D
K
Q
N
N
G
K
G
R
W
G
R
V
W
Y
S
D
E
G
-
G
L
Y
F
S
M
V
L
D
S
K
L
--
Y
N
P
K
V
I
N
L
L
V
P
I
C
I
I
E
V
L
K
N
Y
V
D
K
E
L
G
L
K
F
P
N
D
I
M
V
K
V
ND
N
Y
K
K
L
G
G
I
L
T
E
L
T
D
-----
D
Y
M
I
I
G
I
G
I
N
V
N
N
Q
I
R
N
---
E
I
R
E
I
A
I
S
L
K
E
I
T
G
K
E
L
D
K
V
E
I
L
S
N
F
L
K
T
F
E
S
Y
L
E
K
L
K
N
K
EI
D
---
D
Y
E
I
L
K
K
Y
K
K
Y
S
I
T
I
G
K
Q
V
K
I
L
L
S
N
N
E
I
I
T
G
K
V
Y
D
I
D
F
D
G
I
V
-
L
G
T
E
K
G
I
-
E
R
I
P
S
G
I
C
I
H
---
14
PsiBlast_PDB
51.32
30%
-96
- C2 -
1WQ7
-
?
A:
[16-232]
----------------------------------------------------------------------------------------
F
Q
E
I
T
S
T
N
E
F
A
K
T
S
Y
L
--
E
E
G
T
V
I
V
A
D
K
Q
T
M
G
H
G
------
E
S
P
E
G
-
G
L
W
L
S
I
V
L
S
P
K
V
P
Q
K
D
L
P
K
I
V
F
L
G
A
V
G
V
V
E
T
L
K
E
F
S
I
D
G
-
R
I
K
W
P
N
D
V
L
V
N
Y
----
K
K
I
A
G
V
L
V
E
G
K
G
-----
D
K
I
V
L
G
I
G
L
N
V
N
N
K
V
P
N
-------
G
A
T
S
M
K
L
E
L
G
S
E
V
P
L
L
S
V
F
R
S
L
I
T
N
L
D
R
L
Y
L
N
F
L
K
N
--
P
M
D
I
L
N
L
V
R
D
N
M
I
L
G
V
R
V
--
K
I
L
----
G
D
-
G
S
F
E
G
I
A
E
D
I
D
D
F
G
R
L
I
I
R
L
D
S
G
E
V
K
K
V
I
Y
G
D
V
S
L
---
18
PsiBlast_PDB
51.27
30%
-90
- C2 -
2DTH
2
?
A:
[16-232]
----------------------------------------------------------------------------------------
F
Q
E
I
T
S
T
N
E
F
A
K
T
S
Y
L
--
E
E
G
T
V
I
V
A
D
K
Q
T
M
G
H
G
R
L
N
R
K
W
E
S
P
E
G
-
G
L
W
L
S
I
V
L
S
P
K
V
P
Q
K
D
L
P
K
I
V
F
L
G
A
V
G
V
V
E
T
L
K
E
F
S
I
D
G
-
R
I
K
W
P
N
D
V
L
V
N
Y
----
K
K
I
A
G
V
L
V
E
G
K
G
-----
D
K
I
V
L
G
I
G
L
N
V
N
N
K
V
P
N
-------
G
A
T
S
M
K
L
E
L
G
S
E
V
P
L
L
S
V
F
R
S
L
I
T
N
L
D
R
L
Y
L
N
F
L
K
N
--
P
M
D
I
L
N
L
V
R
D
N
M
I
L
G
V
R
V
--
K
I
L
----
G
D
-
G
S
F
E
G
I
A
E
D
I
D
D
F
G
R
L
I
I
R
L
D
S
G
E
V
K
K
V
I
Y
G
D
V
S
L
---
15
PsiBlast_PDB
50.98
30%
-89
- C2 -
1WQW
1
?
A:
[16-232]
----------------------------------------------------------------------------------------
F
Q
E
I
T
S
T
N
E
F
A
K
T
S
Y
L
--
E
E
G
T
V
I
V
A
D
K
Q
T
M
G
H
G
R
L
N
R
K
W
E
S
P
E
G
-
G
L
W
L
S
I
V
L
S
P
K
V
P
Q
K
D
L
P
K
I
V
F
L
G
A
V
G
V
V
E
T
L
K
E
F
S
I
D
G
-
R
I
K
W
P
N
D
V
L
V
N
Y
----
K
K
I
A
G
V
L
V
E
G
K
G
-----
D
K
I
V
L
G
I
G
L
N
V
N
N
K
V
P
N
-------
G
A
T
S
M
K
L
E
L
G
S
E
V
P
L
L
S
V
F
R
S
L
I
T
N
L
D
R
L
Y
L
N
F
L
K
N
--
P
M
D
I
L
N
L
V
R
D
N
M
I
L
G
V
R
V
--
K
I
L
----
G
D
-
G
S
F
E
G
I
A
E
D
I
D
D
F
G
R
L
I
I
R
L
D
S
G
E
V
K
K
V
I
Y
G
D
V
S
L
---
20
PsiBlast_PDB
50.96
30%
-90
- C2 -
1WPY
1
?
A:
[16-232]
----------------------------------------------------------------------------------------
F
Q
E
I
T
S
T
N
E
F
A
K
T
S
Y
L
--
E
E
G
T
V
I
V
A
D
K
Q
T
M
G
H
G
R
L
N
R
K
W
E
S
P
E
G
-
G
L
W
L
S
I
V
L
S
P
K
V
P
Q
K
D
L
P
K
I
V
F
L
G
A
V
G
V
V
E
T
L
K
E
F
S
I
D
G
-
R
I
K
W
P
N
D
V
L
V
N
Y
----
K
K
I
A
G
V
L
V
E
G
K
G
-----
D
K
I
V
L
G
I
G
L
N
V
N
N
K
V
P
N
-------
G
A
T
S
M
K
L
E
L
G
S
E
V
P
L
L
S
V
F
R
S
L
I
T
N
L
D
R
L
Y
L
N
F
L
K
N
--
P
M
D
I
L
N
L
V
R
D
N
M
I
L
G
V
R
V
--
K
I
L
----
G
D
-
G
S
F
E
G
I
A
E
D
I
D
D
F
G
R
L
I
I
R
L
D
S
G
E
V
K
K
V
I
Y
G
D
V
S
L
---
19
PsiBlast_PDB
50.69
30%
-93
- C2 -
2DTI
3
?
A:
[16-232]
----------------------------------------------------------------------------------------
F
Q
E
I
T
S
T
N
E
F
A
K
T
S
Y
L
--
E
E
G
T
V
I
V
A
D
K
Q
T
M
G
H
G
R
L
N
R
K
W
E
S
P
E
G
-
G
L
W
L
S
I
V
L
S
P
K
V
P
Q
K
D
L
P
K
I
V
F
L
G
A
V
G
V
V
E
T
L
K
E
F
S
I
D
G
-
R
I
K
W
P
N
D
V
L
V
N
Y
----
K
K
I
A
G
V
L
V
E
G
K
G
-----
D
K
I
V
L
G
I
G
L
N
V
N
N
K
V
P
N
-------
G
A
T
S
M
K
L
E
L
G
S
E
V
P
L
L
S
V
F
R
S
L
I
T
N
L
D
R
L
Y
L
N
F
L
K
N
--
P
M
D
I
L
N
L
V
R
D
N
M
I
L
G
V
R
V
--
K
I
L
----
G
D
-
G
S
F
E
G
I
A
E
D
I
D
D
F
G
R
L
I
I
R
L
D
S
G
E
V
K
K
V
I
Y
G
D
V
S
L
---
17
PsiBlast_PDB
50.64
30%
-91
- C2 -
2DKG
3
?
A:
[16-232]
----------------------------------------------------------------------------------------
F
Q
E
I
T
S
T
N
E
F
A
K
T
S
Y
L
--
E
E
G
T
V
I
V
A
D
K
Q
T
M
G
H
G
R
L
N
R
K
W
E
S
P
E
G
-
G
L
W
L
S
I
V
L
S
P
K
V
P
Q
K
D
L
P
K
I
V
F
L
G
A
V
G
V
V
E
T
L
K
E
F
S
I
D
G
-
R
I
K
W
P
N
D
V
L
V
N
Y
----
K
K
I
A
G
V
L
V
E
G
K
G
-----
D
K
I
V
L
G
I
G
L
N
V
N
N
K
V
P
N
-------
G
A
T
S
M
K
L
E
L
G
S
E
V
P
L
L
S
V
F
R
S
L
I
T
N
L
D
R
L
Y
L
N
F
L
K
N
--
P
M
D
I
L
N
L
V
R
D
N
M
I
L
G
V
R
V
--
K
I
L
----
G
D
-
G
S
F
E
G
I
A
E
D
I
D
D
F
G
R
L
I
I
R
L
D
S
G
E
V
K
K
V
I
Y
G
D
V
S
L
---
23
PsiBlast_CBE
44.27
33%
-93
- C2 -
3EFS
3
?
B:
[11-161]
-------------------------------------------------------------------------------------------
V
D
S
T
Q
E
R
L
K
E
W
N
V
S
Y
G
T
A
--
L
V
A
D
R
Q
T
K
G
R
G
R
L
G
R
K
W
L
S
Q
E
G
-
G
L
Y
F
S
F
L
L
N
P
K
-
E
F
E
N
L
L
Q
L
P
L
V
L
G
L
S
V
S
E
A
L
E
E
I
T
E
I
P
F
S
L
K
W
P
N
D
V
Y
F
Q
E
----
K
K
V
S
G
V
L
R
E
L
S
K
D
K
-----
L
I
V
G
I
G
I
N
V
N
Q
R
--
E
I
P
E
E
I
K
D
R
A
T
T
L
Y
E
I
T
G
K
D
W
D
R
K
E
V
L
L
K
V
L
K
R
I
--------------------------------------------------------------------------------
24
PsiBlast_CBE
44.08
33%
-89
- C2 -
3EFS
4
?
A:
[11-161]
-------------------------------------------------------------------------------------------
V
D
S
T
Q
E
R
L
K
E
W
N
V
S
Y
G
T
A
--
L
V
A
D
R
Q
T
K
G
R
G
R
L
G
R
K
W
L
S
Q
E
G
-
G
L
Y
F
S
F
L
L
N
P
K
-
E
F
E
N
L
L
Q
L
P
L
V
L
G
L
S
V
S
E
A
L
E
E
I
T
E
I
P
F
S
L
K
W
P
N
D
V
Y
F
Q
E
----
K
K
V
S
G
V
L
R
E
L
S
K
D
K
-----
L
I
V
G
I
G
I
N
V
N
Q
R
--
E
I
P
E
E
I
K
D
R
A
T
T
L
Y
E
I
T
G
K
D
W
D
R
K
E
V
L
L
K
V
L
K
R
I
--------------------------------------------------------------------------------
25
PsiBlast_CBE
42.69
33%
-84
- C2 -
3EFR
2
?
B:
[11-161]
-------------------------------------------------------------------------------------------
V
D
S
T
Q
E
R
L
K
E
W
N
V
S
Y
G
T
A
--
L
V
A
D
R
Q
T
K
G
R
G
G
L
G
R
K
W
L
S
Q
E
G
-
G
L
Y
F
S
F
L
L
N
P
K
-
E
F
E
N
L
L
Q
L
P
L
V
L
G
L
S
V
S
E
A
L
E
E
I
T
E
I
P
F
S
L
K
W
P
N
D
V
Y
F
Q
E
----
K
K
V
S
G
V
L
R
E
L
S
K
D
K
-----
L
I
V
G
I
G
I
N
V
N
Q
R
--
E
I
P
E
E
I
K
D
R
A
T
T
L
Y
E
I
T
G
K
D
W
D
R
K
E
V
L
L
K
V
L
K
R
I
--------------------------------------------------------------------------------
26
PsiBlast_CBE
41.53
33%
-85
- C2 -
3EFR
3
?
A:
[11-161]
-------------------------------------------------------------------------------------------
V
D
S
T
Q
E
R
L
K
E
W
N
V
S
Y
G
T
A
--
L
V
A
D
R
Q
T
K
G
R
G
G
L
G
R
K
W
L
S
Q
E
G
-
G
L
Y
F
S
F
L
L
N
P
K
-
E
F
E
N
L
L
Q
L
P
L
V
L
G
L
S
V
S
E
A
L
E
E
I
T
E
I
P
F
S
L
K
W
P
N
D
V
Y
F
Q
E
----
K
K
V
S
G
V
L
R
E
L
S
K
D
K
-----
L
I
V
G
I
G
I
N
V
N
Q
R
--
E
I
P
E
E
I
K
D
R
A
T
T
L
Y
E
I
T
G
K
D
W
D
R
K
E
V
L
L
K
V
L
K
R
I
--------------------------------------------------------------------------------