@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0864: (2015-12-19 )
MSNPNLSFYCNECERFESFLKNHYLHLEGFHPYLEKAFFEMVLNGGKRFRPKLFLAVLCSLVGKKDYSNQQTEYFKIALSIECLHTYSLIHDDLPCMDNAILRRNHPTLHAKYDETTAVLIGDALNTYSFELLSNSLLESRIIVELVKILSANGGIKGMILGQALDCYFENTPLNLEQLTFLHEHKTAKLISASLIMGLVASGINDEELLKWLQAFGLKMGLCFQVLDDIIDVTQDEKESGKTTHLDSAKNSFVNLLGLKKASGYAQTLKTEILNDLNALEPTYLSLQENLNALLNTLFKGKT
Atome Classification :
(39 SA)
.......---..10........20.....----...30........40........50........60........70........80........90........100.......110.......120.......130..---..-----.--.---.---140--........--150--.......160....-...170.-.---...---....180.......190.......200-....-.-..210.......220.......230.......240.....--.--.--250-........260.......270.......280.-......290.......300.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSNP
N
L
S
---
F
Y
C
N
E
C
E
R
F
E
S
F
L
K
NH
Y
L
H
----LEGF
H
P
Y
L
E
K
A
F
F
E
M
V
LNGGKRF
R
P
K
L
F
L
A
V
L
C
S
L
VGKKDYSNQQ
T
E
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
HDDLPCM
D
N
A
I
L
RRNHP
T
L
H
A
KYDE
T
T
A
V
L
I
GDAL
N
T
Y
S
F
E
L
L
S
---
N
S
-----
L
--
L
---
E
---
S
R
---
I
I
V
E
L
V
K
I
--
L
SA--NGG
I
K
G
M
I
L
G
Q
A
L
D
-
C
Y
FE--N-T---PL
N
---
L
E
Q
L
T
F
L
H
EH
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
AS-GI
N
D
-
E
-
E
L
L
K
W
L
Q
A
FGLK
M
G
L
C
F
Q
V
L
D
D
I
I
DVTQ
D
E
KESGKTTHLD--
S
--
A
--
K
N
--
S
F
V
N
L
LGLKKAS
G
Y
A
Q
T
L
K
T
E
I
L
N
D
L
N
ALE
P
T
-
Y
L
S
L
Q
E
N
L
N
A
L
L
N
T
L
FKGKT
22
PsiBlast_CBE
96.87
91%
-136
- C1 -
3LLW
2
?
C:
[3-302]
L
S
S
P
N
L
S
---
F
Y
Y
N
E
C
E
R
F
E
S
F
L
K
N
H
H
L
H
----
L
E
S
F
H
P
Y
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
D
Y
S
N
Q
Q
T
E
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
---
N
A
-----
L
--
L
---
E
---
S
H
---
I
I
V
E
L
I
K
I
--
L
S
A
--
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
-
C
Y
F
E
--
N
-
T
---
P
L
N
---
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
I
K
D
-
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
---------------------
K
N
--
S
F
V
N
L
L
G
L
E
R
A
N
N
Y
A
Q
T
L
K
T
E
V
L
N
D
L
D
A
L
K
P
A
-
Y
P
L
L
Q
E
N
L
N
A
L
L
N
T
L
F
K
---
23
PsiBlast_CBE
96.28
91%
-131
- C1 -
3LLW
3
?
B:
[3-303]
L
S
S
P
N
L
S
---
F
Y
Y
N
E
C
E
R
F
E
S
F
L
K
N
H
H
L
H
----
L
E
S
F
H
P
Y
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
D
Y
S
N
Q
Q
T
E
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
---
N
A
-----
L
--
L
---
E
---
S
H
---
I
I
V
E
L
I
K
I
--
L
S
A
--
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
-
C
Y
F
E
--
N
-
T
---
P
L
N
---
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
I
K
D
-
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
--------------------
K
N
--
S
F
V
N
L
L
G
L
E
R
A
N
N
Y
A
Q
T
L
K
T
E
V
L
N
D
L
D
A
L
K
P
A
-
Y
P
L
L
Q
E
N
L
N
A
L
L
N
T
L
F
K
G
--
21
PsiBlast_CBE
96.21
91%
-131
- C1 -
3LLW
2
?
D:
[4-302]
-
S
S
P
N
L
S
---
F
Y
Y
N
E
C
E
R
F
E
S
F
L
K
N
H
H
L
H
----
L
E
S
F
H
P
Y
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
D
Y
S
N
Q
Q
T
E
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
---
N
A
-----
L
--
L
---
E
---
S
H
---
I
I
V
E
L
I
K
I
--
L
S
A
--
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
-
C
Y
F
E
--
N
-
T
---
P
L
N
---
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
I
K
D
-
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
----------
L
D
--
S
--
A
--
K
N
--
S
F
V
N
L
L
G
L
E
R
A
N
N
Y
A
Q
T
L
K
T
E
V
L
N
D
L
D
A
L
K
P
A
-
Y
P
L
L
Q
E
N
L
N
A
L
L
N
T
L
F
K
---
1
PsiBlast_PDB
95.54
91%
-132
- C1 -
3LLW
2
?
A:
[3-302]
L
S
S
P
N
L
S
---
F
Y
Y
N
E
C
E
R
F
E
S
F
L
K
N
H
H
L
H
----
L
E
S
F
H
P
Y
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
D
Y
S
N
Q
Q
T
E
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
---
N
A
-----
L
--
L
---
E
---
S
H
---
I
I
V
E
L
I
K
I
--
L
S
A
--
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
-
C
Y
F
E
--
N
-
T
---
P
L
N
---
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
I
K
D
-
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
-----------------
A
--
K
N
--
S
F
V
N
L
L
G
L
E
R
A
N
N
Y
A
Q
T
L
K
T
E
V
L
N
D
L
D
A
L
K
P
A
-
Y
P
L
L
Q
E
N
L
N
A
L
L
N
T
L
F
K
---
72
HHSearch
95.27
91%
-133
- C1 -
3LLW
2
?
A:
[4-302]
-
S
S
P
N
L
S
---
F
Y
Y
N
E
C
E
R
F
E
S
F
L
K
N
H
H
L
H
----
L
E
S
F
H
P
Y
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
D
Y
S
N
Q
Q
T
E
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
---
N
A
-----
L
--
L
---
E
---
S
H
---
I
I
V
E
L
I
K
I
--
L
S
A
N
G
G
I
--
K
G
M
I
L
G
Q
A
L
D
-
C
Y
F
E
--
N
-
T
---
P
L
N
---
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
-
I
K
D
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
-----------------
A
--
K
N
--
S
F
V
N
L
L
G
L
E
R
A
N
N
Y
A
Q
T
L
K
T
E
V
L
N
D
L
D
A
L
K
P
A
-
Y
P
L
L
Q
E
N
L
N
A
L
L
N
T
L
F
K
---
2
PsiBlast_PDB
95.19
92%
-121
- C1 -
3Q1O
6
?
A:
[10-310]
L
S
S
P
N
L
S
---
F
Y
Y
N
E
C
E
R
F
E
S
F
L
K
N
H
H
L
H
----
L
E
S
F
H
P
Y
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
D
Y
S
N
Q
Q
T
E
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
---
N
A
-----
L
--
L
---
E
---
S
H
---
I
I
V
E
L
I
K
I
--
L
S
A
--
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
-
C
Y
F
E
--
N
-
T
---
P
L
N
---
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
I
K
D
-
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
--
S
--
A
--
K
N
--
S
F
V
N
L
L
G
L
E
R
A
N
N
Y
A
Q
T
L
K
T
E
V
L
N
D
L
D
A
L
K
P
A
-
Y
P
L
L
Q
E
N
L
N
A
L
L
N
T
L
F
K
G
--
26
PsiBlast_CBE
94.75
92%
-119
- C1 -
3Q1O
4
?
B:
[10-310]
L
S
S
P
N
L
S
---
F
Y
Y
N
E
C
E
R
F
E
S
F
L
K
N
H
H
L
H
----
L
E
S
F
H
P
Y
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
D
Y
S
N
Q
Q
T
E
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
---
N
A
-----
L
--
L
---
E
---
S
H
---
I
I
V
E
L
I
K
I
--
L
S
A
--
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
-
C
Y
F
E
--
N
-
T
---
P
L
N
---
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
I
K
D
-
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
--
S
--
A
--
K
N
--
S
F
V
N
L
L
G
L
E
R
A
N
N
Y
A
Q
T
L
K
T
E
V
L
N
D
L
D
A
L
K
P
A
-
Y
P
L
L
Q
E
N
L
N
A
L
L
N
T
L
F
K
G
--
25
PsiBlast_CBE
94.02
92%
-120
- C1 -
3Q1O
7
?
C:
[10-309]
L
S
S
P
N
L
S
---
F
Y
Y
N
E
C
E
R
F
E
S
F
L
K
N
H
H
L
H
----
L
E
S
F
H
P
Y
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
D
Y
S
N
Q
Q
T
E
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
---
N
A
-----
L
--
L
---
E
---
S
H
---
I
I
V
E
L
I
K
I
--
L
S
A
--
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
-
C
Y
F
E
--
N
-
T
---
P
L
N
---
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
I
K
D
-
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
--
S
--
A
--
K
N
--
S
F
V
N
L
L
G
L
E
R
A
N
N
Y
A
Q
T
L
K
T
E
V
L
N
D
L
D
A
L
K
P
A
-
Y
P
L
L
Q
E
N
L
N
A
L
L
N
T
L
F
K
---
24
PsiBlast_CBE
93.81
92%
-117
- C1 -
3Q1O
3
?
D:
[11-309]
-
S
S
P
N
L
S
---
F
Y
Y
N
E
C
E
R
F
E
S
F
L
K
N
H
H
L
H
----
L
E
S
F
H
P
Y
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
D
Y
S
N
Q
Q
T
E
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
---
N
A
-----
L
--
L
---
E
---
S
H
---
I
I
V
E
L
I
K
I
--
L
S
A
--
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
-
C
Y
F
E
--
N
-
T
---
P
L
N
---
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
-
G
I
K
D
-
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
--
S
--
A
--
K
N
--
S
F
V
N
L
L
G
L
E
R
A
N
N
Y
A
Q
T
L
K
T
E
V
L
N
D
L
D
A
L
K
P
A
-
Y
P
L
L
Q
E
N
L
N
A
L
L
N
T
L
F
K
---
75
HHSearch
70.48
45%
-112
- C1 -
3NPK
2
?
A:
[5-283]
--------------
L
K
E
L
F
I
H
H
L
E
K
N
L
P
K
----
V
E
S
F
H
P
F
F
N
E
A
L
A
L
M
L
K
A
G
G
K
H
F
R
A
Q
L
L
L
S
V
V
Q
S
N
K
P
E
L
-----
L
N
Q
A
L
D
V
A
L
A
L
E
F
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
A
D
F
R
R
G
I
P
T
L
H
K
S
Y
D
E
T
T
A
I
L
V
G
D
A
L
N
T
E
A
F
L
V
L
S
---
H
A
-----
H
--
L
---
K
---
D
E
---
I
K
I
K
L
I
K
T
L
A
F
N
A
--
G
L
--
N
G
M
V
I
G
Q
A
I
D
-
C
F
F
E
--
D
-
K
---
R
L
S
---
L
N
E
L
E
F
L
H
T
H
K
T
A
R
L
I
A
A
A
L
K
M
G
C
E
I
C
-
E
-
L
N
-
N
-
E
E
S
N
Q
I
Y
K
L
G
L
K
L
G
L
I
F
Q
I
N
D
D
I
I
D
V
T
----------------------
N
--
S
F
V
N
L
L
G
L
E
Q
A
I
K
T
K
E
N
L
L
N
E
C
E
Q
D
L
E
K
L
N
E
K
-
L
---
A
Q
M
I
Q
N
L
I
I
Q
Y
L
----
3
PsiBlast_PDB
68.72
46%
-104
- C1 -
3NPK
2
?
A:
[7-278]
----------------
E
L
F
I
H
H
L
E
K
N
L
P
K
----
V
E
S
F
H
P
F
F
N
E
A
L
A
L
M
L
K
A
G
G
K
H
F
R
A
Q
L
L
L
S
V
V
Q
S
--
N
K
P
E
L
L
N
Q
A
L
D
---
V
A
L
A
L
E
F
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
A
D
F
R
R
G
I
P
T
L
H
K
S
Y
D
E
T
T
A
I
L
V
G
D
A
L
N
T
E
A
F
L
V
L
S
---
H
A
-----
H
--
L
---
K
---
D
E
---
I
K
I
K
L
I
K
T
--
L
A
F
--
N
A
G
L
N
G
M
V
I
G
Q
A
I
D
-
C
F
F
E
--
D
-
K
---
R
L
S
---
L
N
E
L
E
F
L
H
T
H
K
T
A
R
L
I
A
A
A
L
K
M
G
C
E
I
C
-
E
L
N
N
-
E
-
E
-
S
N
Q
I
Y
K
L
G
L
K
L
G
L
I
F
Q
I
N
D
D
I
I
D
V
T
----------------------
N
--
S
F
V
N
L
L
G
L
E
Q
A
I
K
T
K
E
N
L
L
N
E
C
E
Q
D
L
E
K
L
N
E
K
-
L
A
Q
M
I
Q
N
L
I
I
Q
Y
L
-------
69
HHSearch
64.35
36%
-102
- C1 -
3LSN
3
?
A:
[4-292]
-----
T
A
---
Y
Q
A
S
S
Q
A
R
V
D
A
A
M
H
T
L
F
T
A
----
P
S
P
E
L
A
R
L
Y
E
A
M
R
Y
S
V
M
N
G
G
K
R
V
R
P
L
L
A
Y
A
A
C
E
A
L
G
G
K
P
------
E
Q
A
N
G
A
A
C
A
V
E
L
I
H
A
Y
S
L
V
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
Q
P
T
T
H
K
A
F
D
E
A
C
A
I
L
A
G
D
G
L
Q
S
L
A
F
S
A
L
L
---
D
P
-----
A
--
L
---
S
DAS
A
E
---
I
R
L
R
M
V
T
T
--
L
A
Q
--
A
A
G
P
A
G
M
V
G
G
Q
A
I
D
-
L
G
S
V
--
G
-
L
---
K
L
D
---
Q
Q
A
L
E
Y
M
H
R
H
K
T
G
A
L
I
E
A
S
V
I
L
G
A
L
A
S
-
G
-
R
A
-
E
K
G
E
L
K
A
L
Q
T
Y
A
Q
A
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
E
S
D
T
A
T
L
----------------
P
--
T
Y
P
A
L
L
G
L
A
A
A
K
E
Y
A
L
E
L
R
D
Q
A
L
H
A
L
R
P
F
D
A
A
-
A
E
P
L
R
E
L
A
R
Y
I
V
E
-------
77
HHSearch
62.89
36%
-115
- C1 -
2J1P
2
GGPPS_SINAL
A:
[14-289]
-----
I
S
---
Y
I
I
R
K
A
D
S
V
N
K
A
L
D
S
A
V
P
L
----
R
-
E
-
P
L
K
I
H
E
A
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
V
L
C
I
A
A
C
E
L
V
G
G
E
E
------
S
L
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
I
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
K
V
Y
G
E
D
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
L
A
---
S
A
-----
T
--
S
---
S
EVS
P
A
---
R
V
V
R
A
V
G
E
--
L
A
K
--
A
I
G
T
E
G
L
V
A
G
Q
V
V
D
-
I
S
------
L
DLN
N
V
G
---
L
E
H
L
K
F
I
H
L
H
K
T
A
A
L
L
E
A
S
A
V
L
G
G
I
I
G
-
G
-
G
S
-
D
-
E
E
I
E
R
L
R
K
F
A
R
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
--------------------
K
L
--
T
Y
P
K
L
M
G
L
E
K
S
R
E
F
A
E
K
L
N
T
E
A
R
D
Q
L
L
G
F
D
S
D
-
K
---
V
A
P
L
L
A
L
A
N
Y
I
A
N
R
Q
N
11
PsiBlast_PDB
62.46
39%
-120
- C1 -
3KRP
3
?
A:
[39-277]
------------------------------------------------
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
E
L
V
G
-----
G
D
E
S
T
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
---
A
A
-----
T
KG
A
---
P
---
P
E
---
R
I
V
R
V
L
G
E
--
L
A
V
--
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
-
A
---
E
V
G
---
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
-
E
-
E
V
A
K
-
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
--------------------
K
T
--
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
H
-
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
---
65
HHSearch
61.46
34%
-104
- C1 -
3TS7
2
?
A:
[9-288]
----
L
S
D
---
F
M
R
S
S
Q
E
R
V
E
R
A
L
D
A
R
L
P
A
----
A
D
R
M
P
E
R
L
H
Q
A
M
R
Y
S
V
L
G
G
G
K
R
M
R
P
L
L
T
Y
A
T
G
Q
T
I
G
V
A
A
------
D
L
L
D
G
P
A
C
A
V
E
F
I
H
V
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
C
H
K
A
Y
D
E
A
T
A
I
L
A
G
D
G
L
Q
A
L
A
F
H
V
L
A
---
Q
D
-----
P
--
S
IAV
P
---
A
E
---
N
R
I
A
M
I
E
T
--
L
A
K
--
A
S
G
P
A
G
M
V
G
G
Q
A
I
D
-
L
A
S
V
--
G
-
K
---
K
L
D
---
L
P
G
L
E
N
M
H
I
R
K
T
G
A
L
I
R
A
S
V
R
L
A
C
L
A
R
P
G
-
L
P
-
A
-
E
Q
F
D
R
L
D
H
Y
A
K
C
I
G
L
A
F
Q
I
Q
D
D
I
L
D
E
E
S
D
-------------------
K
P
--
N
Y
P
A
L
L
G
L
S
G
A
K
E
K
A
E
E
M
H
E
A
A
L
E
S
L
A
G
F
G
P
E
-
A
D
L
L
R
E
L
A
R
F
I
I
Q
R
Q
S
A
E
N
L
70
HHSearch
61.34
31%
-110
- C1 -
1RTR
-
?
A:
[7-289]
------------
N
K
L
I
D
E
V
N
N
E
L
S
V
A
I
N
K
----
S
V
M
-
D
T
Q
L
E
E
S
M
L
Y
S
L
N
A
G
G
K
R
I
R
P
V
L
L
L
L
T
L
D
S
L
N
T
E
Y
------
E
L
G
M
K
S
A
I
A
L
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
K
L
T
N
H
K
V
Y
G
E
W
T
A
I
L
A
G
D
A
L
L
T
K
A
F
E
L
I
S
---
S
D
-----
D
--
R
L--
T
---
D
E
---
V
K
I
K
V
L
Q
R
--
L
S
I
--
A
S
G
H
V
G
M
V
G
G
Q
M
L
D
-
M
Q
S
E
--
G
-
Q
---
P
I
D
---
L
E
T
L
E
M
I
H
K
T
K
T
G
A
L
L
T
F
A
V
M
S
A
A
D
I
A
-
N
-
V
D
-
D
-
T
T
K
E
H
L
E
S
Y
S
Y
H
L
G
M
M
F
Q
I
K
D
D
L
L
D
C
Y
G
D
E
A
-----------------
K
S
--
T
Y
V
S
L
L
G
K
D
G
A
E
D
K
L
T
Y
H
R
D
A
A
V
D
E
L
T
Q
I
D
E
Q
-
F
N
--
T
K
H
L
L
E
I
V
D
L
F
Y
S
R
--
32
PsiBlast_CBE
61.03
39%
-115
- C1 -
3KRP
3
?
D:
[39-277]
------------------------------------------------
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
E
L
V
G
-----
G
D
E
S
T
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
---
A
A
-----
T
KG
A
---
P
---
P
E
---
R
I
V
R
V
L
G
E
--
L
A
V
--
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
-
A
---
E
V
G
---
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
-
E
-
E
V
A
K
-
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
-----------------
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
H
-
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
---
47
PsiBlast_CBE
60.97
34%
-93
* C1 *
3TS7
3
?
B:
[4-292]
--
N
P
E
R
S
L
S
D
F
M
R
S
S
Q
E
R
V
E
R
A
L
D
A
R
L
P
A
----
A
D
R
M
P
E
R
L
H
Q
A
M
R
Y
S
V
L
G
G
G
K
R
M
R
P
L
L
T
Y
A
T
G
Q
T
I
G
V
A
A
D
L
L
D
G
P
------
A
C
A
V
E
F
I
H
V
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
C
H
K
A
Y
D
E
A
T
A
I
L
A
G
D
G
L
Q
A
L
A
F
H
V
L
A
---
Q
D
PSIAV
P
--
A
---
E
---
N
R
---
I
A
--
M
I
E
T
--
L
A
K
--
A
S
G
P
A
G
M
V
G
G
Q
A
I
D
-
L
A
S
V
--
G
-
K
---
K
L
D
---
L
P
G
L
E
N
M
H
I
R
K
T
G
A
L
I
R
A
S
V
R
L
A
C
L
A
R
-
P
G
L
P
-
A
-
E
Q
F
D
R
L
D
H
Y
A
K
C
I
G
L
A
F
Q
I
Q
D
D
I
L
D
E
E
S
D
T
Q
T
L
-----------------KP
N
Y
P
A
L
L
G
L
S
G
A
K
E
K
A
E
E
M
H
E
A
A
L
E
S
L
A
G
F
G
P
E
-
A
D
L
L
R
E
L
A
R
F
I
I
Q
R
Q
S
A
E
N
L
12
PsiBlast_PDB
60.88
39%
-122
- C1 -
3OAB
4
?
A:
[39-277]
------------------------------------------------
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
E
L
V
G
-----
G
D
E
S
T
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
---
A
A
-----
T
KG
A
---
P
---
P
E
---
R
I
V
R
V
L
G
E
--
L
A
V
--
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
-
A
---
E
V
G
---
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
-
E
-
E
V
A
K
-
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
--------------------
K
T
--
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
H
-
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
---
66
HHSearch
60.87
35%
-107
- C1 -
3UCA
-
?
A:
[11-288]
-----
A
M
---
N
I
N
S
L
K
E
E
V
D
Q
S
L
K
A
Y
F
N
K
----
D
R
E
Y
N
K
V
L
Y
D
S
M
A
Y
S
I
N
V
G
G
K
R
I
R
P
I
L
M
L
L
S
Y
Y
I
Y
K
S
D
Y
------
K
K
I
L
T
P
A
M
A
I
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
K
V
F
G
E
A
I
A
V
L
A
G
D
A
L
L
N
E
A
M
K
I
L
V
---
D
Y
-----
S
--
L
E
--
E
---
G
K
---
S
A
L
K
A
T
K
I
--
I
A
D
--
A
A
G
S
D
G
M
I
G
G
Q
I
V
D
-
I
I
N
E
--
D
K
E
---
E
I
S
---
L
K
E
L
D
Y
M
H
L
K
K
T
G
E
L
I
K
A
S
I
M
S
G
A
V
L
A
-
E
-
A
S
-
E
-
G
D
I
K
K
L
E
G
F
G
Y
K
L
G
L
A
F
Q
I
K
D
D
I
L
D
V
V
G
---------------------
N
--
N
Y
I
T
I
F
G
L
E
E
C
K
K
K
C
V
N
I
T
E
E
C
I
E
I
L
S
S
I
K
G
N
-
T
E
P
L
K
V
L
T
M
K
L
L
E
R
K
F
----
64
HHSearch
60.64
34%
-100
- C1 -
3PDE
5
?
A:
[9-297]
-----
I
A
---
F
E
D
Q
W
V
P
A
L
N
A
P
L
K
Q
A
I
L
A
----
D
S
Q
-
D
A
Q
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
Q
S
L
G
V
T
F
----
V
P
E
R
H
W
R
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
W
L
T
---
A
T
-----
D
--
L
---
P
---
A
T
---
M
Q
A
A
L
V
Q
A
--
L
A
T
--
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
-
I
Q
S
E
--
H
-
V
---
N
L
P
---
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
V
Q
A
G
L
I
L
G
-
Q
-
A
P
-
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
-----------A
D
E
--
A
--
K
N
--
T
Y
P
G
K
L
G
L
I
G
A
N
Q
A
L
I
D
T
I
H
S
G
Q
A
A
L
Q
G
L
P
T
S
-
T
Q
--
R
D
D
L
A
A
F
F
S
Y
F
D
T
E
R
V
71
HHSearch
60.58
33%
-91
- C1 -
1RQJ
5
ISPA_ECOLI
A:
[4-294]
-----
P
Q
---
Q
L
E
A
C
V
K
Q
A
N
Q
A
L
S
R
F
I
A
P
----
L
P
F
Q
N
T
P
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
H
M
F
G
V
S
T
------
N
T
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
---
D
A
-----
D
--
M
---
P
---
E
V
S
D
R
D
R
I
S
M
I
S
E
--
L
A
S
--
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
-
L
D
A
E
--
G
-
K
---
H
V
P
---
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
-
G
-
D
K
-
G
R
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
--
G
--
K
S
--
T
Y
P
A
L
L
G
L
E
Q
A
R
K
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
A
E
Q
S
L
D
--
T
S
A
L
E
A
L
A
D
Y
I
I
Q
R
N
K
6
PsiBlast_PDB
59.88
35%
-79
- C1 -
4LLT
5
?
A:
[13-302]
L
G
T
E
N
L
Y
---
F
Q
S
M
F
T
Q
R
L
D
A
A
A
A
A
V
Q
A
H
F
D
K
V
L
A
A
F
E
P
L
P
I
V
E
A
M
A
H
A
T
S
G
G
K
R
L
R
G
F
L
V
L
E
T
------
A
R
L
H
D
I
A
A
G
E
A
I
W
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
T
HP-
G
A
-----
S
--
A
---
S
---
A
E
---
V
R
A
D
L
A
L
S
--
L
A
R
--
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
-
I
A
A
E
T
A
R
-
A
---
P
L
S
---
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
-
Q
A
D
T
-
A
-
A
L
K
R
Y
A
Q
A
----
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
--
A
--
S
A
G
K
A
--
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
S
L
I
D
E
A
C
D
S
L
A
T
Y
G
A
K
-
A
D
T
L
R
E
T
A
R
F
V
V
R
R
T
H
----
35
PsiBlast_CBE
59.62
39%
-116
- C1 -
3KRC
1
?
D:
[39-277]
------------------------------------------------
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
E
L
V
G
-----
G
D
E
S
T
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
---
A
A
-----
T
KG
A
---
P
---
P
E
---
R
I
V
R
V
L
G
E
--
L
A
V
--
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
-
A
---
E
V
G
---
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
-
E
-
E
V
A
K
-
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
----------------------
T
--
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
H
-
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
---
8
PsiBlast_PDB
58.74
39%
-119
- C1 -
3KRC
1
?
A:
[39-277]
------------------------------------------------
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
E
L
V
G
-----
G
D
E
S
T
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
---
A
A
-----
T
KG
A
---
P
---
P
E
---
R
I
V
R
V
L
G
E
--
L
A
V
--
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
-
A
---
E
V
G
---
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
-
E
-
E
V
A
K
-
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
--------------------
K
T
--
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
H
-
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
---
39
PsiBlast_CBE
57.48
38%
-102
- C1 -
3ZOU
9
?
B:
[40-286]
------------------------------------------------
V
M
N
G
G
K
R
V
R
P
L
L
A
Y
A
A
C
E
A
L
G
G
A
P
Q
R
A
D
------
A
A
A
C
A
V
E
L
I
H
A
Y
S
L
V
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
Q
P
T
T
H
R
A
F
D
E
A
T
A
I
L
A
A
D
G
L
Q
A
L
A
F
E
V
L
A
---
D
T
-----
R
--
R
NPQ
E
---
H
A
---
V
C
L
E
M
L
T
R
--
L
A
R
--
A
A
G
S
A
G
M
V
G
G
Q
A
I
D
-
L
G
S
V
--------
A
L
D
---
Q
A
A
L
E
V
M
H
R
H
K
T
G
A
L
I
E
A
S
V
R
L
G
A
L
A
S
-
G
R
A
E
-
P
-
A
S
L
A
A
L
E
R
Y
A
E
A
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
E
-----------------------P-
T
Y
P
A
L
L
G
L
E
A
A
K
G
Y
A
L
E
L
R
D
L
A
L
A
A
L
D
G
F
P
P
S
-
A
D
P
L
R
Q
L
A
R
Y
I
V
E
-------
5
PsiBlast_PDB
57.13
35%
-75
- C1 -
4LLS
6
?
A:
[13-302]
L
G
T
E
N
L
Y
---
F
Q
S
M
F
T
Q
R
L
D
A
A
A
A
A
V
Q
A
H
F
D
K
V
L
A
A
F
E
P
L
P
I
V
E
A
M
A
H
A
T
S
G
G
K
R
L
R
G
F
L
V
L
E
T
------
A
R
L
H
D
I
A
A
G
E
A
I
W
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
T
HP-
G
A
-----
S
--
A
---
S
---
A
E
---
V
R
A
D
L
A
L
S
--
L
A
R
--
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
-
I
A
A
E
T
A
R
-
A
---
P
L
S
---
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
-
Q
A
D
T
-
A
-
A
L
K
R
Y
A
Q
A
----
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
--
A
--
S
AG
K
A
--
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
S
L
I
D
E
A
C
D
S
L
A
T
Y
G
A
K
-
A
D
T
L
R
E
T
A
R
F
V
V
R
R
T
H
----
29
PsiBlast_CBE
56.28
35%
-77
- C1 -
4LLS
6
?
B:
[22-302]
------------
S
M
F
T
Q
R
L
D
A
A
A
A
A
V
Q
A
H
F
D
K
V
L
A
A
F
E
P
L
P
I
V
E
A
M
A
H
A
T
S
G
G
K
R
L
R
G
F
L
V
L
E
T
------
A
R
L
H
D
I
A
A
G
E
A
I
W
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
T
HP-
G
A
-----
S
--
A
---
S
---
A
E
---
V
R
A
D
L
A
L
S
--
L
A
R
--
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
-
I
A
A
E
T
A
R
-
A
---
P
L
S
---
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
-
Q
A
D
T
-
A
-
A
L
K
R
Y
A
Q
A
----
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
--
A
--
S
A
G
K
A
--
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
S
L
I
D
E
A
C
D
S
L
A
T
Y
G
A
K
-
A
D
T
L
R
E
T
A
R
F
V
V
R
R
T
H
----
28
PsiBlast_CBE
55.56
35%
-78
- C1 -
4LLT
5
?
B:
[22-302]
------------
S
M
F
T
Q
R
L
D
A
A
A
A
A
V
Q
A
H
F
D
K
V
L
A
A
F
E
P
L
P
I
V
E
A
M
A
H
A
T
S
G
G
K
R
L
R
G
F
L
V
L
E
T
------
A
R
L
H
D
I
A
A
G
E
A
I
W
S
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
T
HP-
G
A
-----
S
--
A
---
S
---
A
E
---
V
R
A
D
L
A
L
S
--
L
A
R
--
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
-
I
A
A
E
TA
R
-
A
---
P
L
S
---
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
-
Q
A
D
T
-
A
-
A
L
K
R
Y
A
Q
A
----
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
--
A
--
S
A
G
K
A
--
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
S
L
I
D
E
A
C
D
S
L
A
T
Y
G
A
K
-
A
D
T
L
R
E
T
A
R
F
V
V
R
R
T
H
----
17
PsiBlast_PDB
55.37
38%
-104
- C1 -
3ZMB
3
?
A:
[40-286]
------------------------------------------------
V
M
N
G
G
K
R
V
R
P
L
L
A
Y
A
A
C
E
A
L
G
G
A
P
Q
R
A
D
------
A
A
A
C
A
V
E
L
I
H
A
Y
S
L
V
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
Q
P
T
T
H
R
A
F
D
E
A
T
A
I
L
A
A
D
G
L
Q
A
L
A
F
E
V
L
A
---
D
T
-----
R
--
R
NPQ
E
---
H
A
---
V
C
L
E
M
L
T
R
--
L
A
R
--
A
A
G
S
A
G
M
V
G
G
Q
A
I
D
-
L
G
S
V
--------
A
L
D
---
Q
A
A
L
E
V
M
H
R
H
K
T
G
A
L
I
E
A
S
V
R
L
G
A
L
A
S
-
G
R
A
E
-
P
-
A
S
L
A
A
L
E
R
Y
A
E
A
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
E
-----------------------P-
T
Y
P
A
L
L
G
L
E
A
A
K
G
Y
A
L
E
L
R
D
L
A
L
A
A
L
D
G
F
P
P
S
-
A
D
P
L
R
Q
L
A
R
Y
I
V
E
R
R
-----
34
PsiBlast_CBE
54.85
39%
-97
- C1 -
3KRF
4
?
D:
[39-277]
------------------------------------------------
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
E
L
V
G
-----
G
D
E
S
T
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
---
A
A
-----
T
KG
A
---
P
---
P
E
---
R
I
V
R
V
L
G
E
--
L
A
V
--
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
-
A
---
E
V
G
---
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
-
E
-
E
V
A
K
-
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
LV
A
--
D
--
K
T
--
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
H
-
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
---
31
PsiBlast_CBE
54.41
39%
-95
- C1 -
3OAB
4
?
D:
[39-277]
------------------------------------------------
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
E
L
V
G
-----
G
D
E
S
T
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
---
A
A
-----
T
KG
A
---
P
---
P
E
---
R
I
V
R
V
L
G
E
--
L
A
V
--
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
-
A
---
E
V
G
---
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
-
E
-
E
V
A
K
-
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
LV
A
--
D
--
K
T
--
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
H
-
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
---
33
PsiBlast_CBE
53.91
39%
-98
- C1 -
3KRO
4
?
D:
[39-277]
------------------------------------------------
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
E
L
V
G
-----
G
D
E
S
T
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
---
A
A
-----
T
KG
A
---
P
---
P
E
---
R
I
V
R
V
L
G
E
--
L
A
V
--
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
-
A
---
E
V
G
---
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
-
E
-
E
V
A
K
-
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
LV
A
--
D
--
K
T
--
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
H
-
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
---
30
PsiBlast_CBE
53.01
39%
-94
- C1 -
3OAC
4
?
D:
[39-277]
------------------------------------------------
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
A
-
C
E
L
V
G
-----
G
D
E
S
T
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
---
A
A
-----
T
KG
A
---
P
---
P
E
---
R
I
V
R
V
L
G
E
--
L
A
V
--
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
V
C
S
E
G
--
M
-
A
---
E
V
G
---
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
-
G
G
K
E
-
E
-
E
V
A
K
-
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
LV
A
--
D
--
K
T
--
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
D
R
L
N
R
E
A
Q
E
Q
L
L
H
F
H
P
H
-
R
A
A
P
L
I
A
L
A
N
Y
I
A
Y
R
D
N
---
20
PsiBlast_PDB
51.76
36%
-80
- C1 -
1RQI
6
ISPA_ECOLI
A:
[32-278]
--------------------------------------
P
V
V
E
T
M
Q
Y
G
A
L
L
-
G
G
K
R
L
R
P
F
L
V
Y
A
T
------
G
H
M
F
G
V
S
T
N
T
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
---
D
A
-----
D
--
M
PEV
S
---
D
R
---
D
R
I
S
M
I
S
E
--
L
A
S
--
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
-
L
D
A
E
--
G
-
K
---
H
V
P
---
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
-
G
D
K
G
-
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
--
Q
Q
L
G
--
K
S
--
T
Y
P
A
L
L
G
L
E
Q
A
R
K
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
A
E
Q
-
S
L
D
T
S
A
L
E
A
L
A
D
Y
I
I
Q
R
N
K
-
19
PsiBlast_PDB
51.31
36%
-79
- C1 -
1RQJ
5
ISPA_ECOLI
A:
[31-277]
--------------------------------------
P
V
V
E
T
M
Q
Y
G
A
L
L
-
G
G
K
R
L
R
P
F
L
V
Y
A
T
------
G
H
M
F
G
V
S
T
N
T
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
---
D
A
-----
D
--
M
PEV
S
---
D
R
---
D
R
I
S
M
I
S
E
--
L
A
S
--
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
-
L
D
A
E
--
G
-
K
---
H
V
P
---
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
-
G
D
K
G
-
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
--
Q
Q
L
G
--
K
S
--
T
Y
P
A
L
L
G
L
E
Q
A
R
K
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
A
E
Q
-
S
L
D
T
S
A
L
E
A
L
A
D
Y
I
I
Q
R
N
K
-
45
PsiBlast_CBE
51.18
36%
-77
- C1 -
1RQI
5
ISPA_ECOLI
B:
[32-278]
--------------------------------------
P
V
V
E
T
M
Q
Y
G
A
L
L
-
G
G
K
R
L
R
P
F
L
V
Y
A
T
------
G
H
M
F
G
V
S
T
N
T
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
---
D
A
-----
D
--
M
PEV
S
---
D
R
---
D
R
I
S
M
I
S
E
--
L
A
S
--
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
-
L
D
A
E
--
G
-
K
---
H
V
P
---
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
-
G
D
K
G
-
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
--
Q
Q
L
G
--
K
S
--
T
Y
P
A
L
L
G
L
E
Q
A
R
K
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
A
E
Q
-
S
L
D
T
S
A
L
E
A
L
A
D
Y
I
I
Q
R
N
K
-
44
PsiBlast_CBE
50.48
36%
-78
- C1 -
1RQJ
5
ISPA_ECOLI
B:
[31-277]
--------------------------------------
P
V
V
E
T
M
Q
Y
G
A
L
L
-
G
G
K
R
L
R
P
F
L
V
Y
A
T
------
G
H
M
F
G
V
S
T
N
T
L
D
A
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
---
D
A
-----
D
--
M
PEV
S
---
D
R
---
D
R
I
S
M
I
S
E
--
L
A
S
--
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
-
L
D
A
E
--
G
-
K
---
H
V
P
---
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
-
G
D
K
G
-
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
--
Q
Q
L
G
--
K
S
--
T
Y
P
A
L
L
G
L
E
Q
A
R
K
K
A
R
D
L
I
D
D
A
R
Q
S
L
K
Q
L
A
E
Q
-
S
L
D
T
S
A
L
E
A
L
A
D
Y
I
I
Q
R
N
K
-
14
PsiBlast_PDB
50.48
40%
-113
- C1 -
2J1P
2
GGPPS_SINAL
A:
[48-270]
------------------------------------------------
L
L
A
G
G
K
R
V
R
P
V
L
C
I
A
A
-
C
E
L
V
G
-----
G
E
E
S
L
A
M
P
A
A
C
A
V
E
M
I
H
T
M
S
L
I
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
K
V
Y
G
E
D
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
L
A
S
AT
S
S
-----
E
--
V
---
S
---
P
A
---
R
V
V
R
A
V
G
E
--
L
A
K
--
A
I
G
T
E
G
L
V
A
G
Q
V
V
D
-
I
S
------
L
---
D
L
N
NV
G
L
E
H
L
K
F
I
H
L
H
K
T
A
A
L
L
E
A
S
A
V
L
G
G
I
I
G
-
G
G
S
D
-
E
-
E
-
I
E
R
L
R
K
F
A
R
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
--------------------
K
L
--
T
Y
P
K
L
M
G
L
E
K
S
R
E
F
A
E
K
L
N
T
E
A
R
D
Q
L
L
G
F
D
S
D
-
K
V
A
P
L
L
A
L
A
N
Y
I
A
N
R
Q
N
---