@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0136: (2016-03-12 )
MLKTIIKRVLQIIPMLFIISIISFALIKLAPGDPVNSFVTPDMNPDDVERIRQSLGLDQPIYVQYFIWLGNLLQGNLGYSIVNSQPVLQQILERIPATLGLVGTSLVLTLLLSIPLGLVAANYENTWIDKVLNGISYIGISIPIFWFGMILIDVFSIQLGWLPSLGMRTIGVDSFWDMAEHAILPVITLTFQGCAAYYRYVRSNTINQLKEEYVLFGYAKGLSKVQIMGHHVLKNSLLPVITLLGMSLPQVITGAFITESIFSWPGMGSLGINAIFQLDYPVIMAITLFSALLLIIGNLLADLAYMIVDPRIREMG
Atome Classification :
(20 SA)
-------------------.........10...-...---------------..20....-....------30.---.......40.-.-----....--..50...--.....60.....-...70........80.....-...90........100.........-110..-.-....120..------....-.130.....------..140.......150.......160....-----....170.......180.......190......--.--200.......210.......220.......230.......240.......250.--......260-.-.-.-.-------------..-.270....----..---.-280-----.......----290.-......300.-......310..-..-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------
M
L
K
T
I
I
K
R
V
L
Q
I
I
P
-
M
L
F
---------------
I
I
S
I
I
S
F
A
-
L
I
KL------APG---DPVNSFVTPD-M-----
N
P
D
D
--
V
E
R
I
R
Q
S--LGLDQ
P
I
Y
V
Q
Y
F
-
I
W
L
G
N
L
LQGNLG
Y
S
IVNS
Q
P
-
V
L
Q
Q
I
L
E
RI
P
A
T
L
G
--
L
V
G
T
S
L
V
L
T
-
L
L
L
SI-
P
-
L
G
L
VAANY
E
------
N
T
W
I
-
D
K
V
LNGI
S
Y
------IGI
S
I
P
I
F
W
F
G
M
I
L
I
D
V
F
S
I
QLG-WLPSL-----G
M
R
T
IG
V
D
S
F
W
D
M
A
E
H
A
I
L
P
V
I
T
L
T
F
Q
G
C
A
A
Y
Y
--
R
--
Y
V
R
SN
T
I
N
Q
L
K
E
E
Y
V
L
F
G
YAKGLS
K
V
Q
I
M
G
H
H
V
L
K
N
S
L
L
P
V
I
T
L
L
GMS
L
P
Q
V
I
T
--
G
A
F
I
T
E
S
I
F-S-W-P-G-------------MG-
S
L
G
I
N
A
I
F
----QL---D-
Y
P
V
-----
I
M
A
I
T
L
F
----
S
A
L
L
-
L
I
I
G
N
L
L
A
D
L
-
A
Y
M
IVDP
R
I
RE-MG-
10
HHSearch
77.85
14%
-123
- C5 -
3RLF
2
MALF_ECOLI
F:
[272-503]
---------------------------------------------------------------------------------------------------------------------------------------------
G
-
I
Q
K
P
F
L
A
I
F
V
W
T
V
V
--
F
S
L
I
T
V
F
L
T
-
V
A
V
G
M
-
V
-
L
A
C
L
V
Q
W
E
A
-------
L
R
G
-
K
A
V
Y
R
V
L
L
I
------
L
P
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
F
N
Q
S
F
G
-
E
I
N
M
M
LSALF
G
V
K
P
---
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
--
I
--
L
C
M
G
L
L
K
A
I
-
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
--
N
F
V
L
I
Q
L
L
T
-
N
G
G
-
P
-
D
RLGTTTPAGYTDL
L
V
-
N
Y
T
Y
R
I
A
F
EGGG
G
Q
---
D
-
F
G
L
-----
A
A
A
I
A
T
L
----
I
F
L
L
-
V
G
A
L
A
I
--------------------
7
HHSearch
75.66
16%
-125
- C5 -
3TUI
-
METI_ECOLI
A:
[2-216]
-------------------------------------------------------------------------------------------------------------------------------------------
S
E
P
-
M
M
W
L
L
V
R
G
V
W
E
T
L
A
--
M
T
F
V
S
G
F
F
G
-
F
V
I
G
L
-
P
-
V
G
V
L
L
Y
V
T
R
PGQIIA
N
A
K
L
-
Y
R
T
V
S
A
I
V
N
------
I
F
R
S
I
P
F
I
I
L
L
V
W
M
I
P
F
T
R
V
I
V
------------
G
T
-----------
S
I
G
L
Q
A
A
I
V
P
L
T
V
G
A
A
P
F
I
A
--
R
--
M
V
E
N
A
L
L
E
I
-
P
T
G
L
I
E
A
S
R
A
M
G
A
T
P
M
Q
I
V
R
K
V
L
L
P
E
A
L
P
G
L
V
N
A
A
T
I
T
L
I
T
L
V
G
--
Y
S
A
M
G
G
-
A
V
-
G
-
A
-
G
-
G
-------------
L
G
-
Q
I
G
Y
Q
Y
G
Y
----
I
G
---
Y
N
A
T
V
-----
M
N
T
V
L
V
L
----
L
V
I
L
-
V
Y
L
I
Q
F
A
G
D
R
-
I
V
R
A
V
T
R
--------
9
HHSearch
73.14
15%
-127
- C5 -
2ONK
-
WTPB_ARCFU
C:
[68-275]
-------------------------------------------------------------------------------------------------------------------------------------------------
P
A
V
W
K
V
V
L
T
T
Y
Y
--
A
A
L
I
S
T
L
I
A
-
V
I
F
G
T
-
P
-
L
A
Y
I
L
A
R
K
S
-------
F
P
G
-
K
S
V
V
E
G
I
V
D
------
L
P
V
V
I
P
H
T
V
A
G
I
A
L
L
V
V
F
G
S
-
S
G
-
L
I
G
S
F
-----
S
P
--------
L
K
F
V
D
A
L
P
G
I
V
V
A
M
L
F
V
S
V
P
I
Y
I
--
N
--
Q
A
K
E
G
F
A
S
V
-
D
V
R
L
E
H
V
A
R
T
L
G
S
S
P
L
R
V
F
F
T
V
S
L
P
L
S
V
R
H
I
V
A
G
A
I
M
S
W
A
R
G
I
S
--
E
F
G
A
V
V
V
I
A
-
Y
-
Y
P
M
-
I
-------------
A
P
-
T
L
I
Y
E
R
Y
L
----
S
E
---
G
-
L
S
A
-----
A
M
P
V
A
A
I
----
L
I
L
L
-
S
L
A
V
F
V
A
L
R
I
-
I
V
G
------------
17
Fugue
71.54
20%
-85
- C4 -
4RWR
-
?
A:
[55-323]
-------------------
V
Y
R
E
K
Q
K
K
V
-
E
S
L
P
M
E
E
Y
---------------
V
T
G
V
V
A
S
E
M
N
A
S
F
E
I
E
A
L
K
A
Q
A
---
L
A
A
R
T
F
V
V
Q
R
M
L
S
GGKK
N
N
A
D
--
V
T
D
T
D
Q
V
--
Y
K
S
K
E
E
L
K
K
Q
W
----------
G
N
------
N
Y
E
N
-
N
L
K
K
I
E
E
A
V
S
K
T
A
G
--
Q
----------
V
L
T
Y
-
E
-
G
K
P
I
S
A
S
F
F
------
S
T
S
N
-
G
R
T
E
N
A
A
D
Y
------
W
G
N
D
Y
P
------------------
Y
L
K
S
------------
V
D
S
P
W
D
Q
A
S
P
K
F
T
S
E
Q
I
F
T
V
A
D
F
Q
K
R
L
G
V
K
--
V
L
A
D
G
K
V
G
D
I
K
G
R
----
T
E
G
K
R
V
K
D
V
A
F
Q
G
K
T
L
T
G
R
D
V
R
D
K
L
E
L
R
S
S
D
F
T
W
K
Q
E
--
G
D
K
I
V
V
T
T
K
-
G
-
F
-
G
H
G
-------------
V
G
M
S
-------------------------------
Q
Y
----
G
A
N
G
M
A
A
E
G
K
K
Y
T
D
I
V
A
H
Y
Y
K
G
V
E
I
K
T
M
N
D
Y
8
HHSearch
68.83
14%
-123
- C5 -
3D31
-
?
C:
[78-283]
-------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
I
S
S
I
F
L
S
L
Y
--
A
G
F
L
A
T
L
L
A
-
L
L
L
G
A
-
P
-
T
G
Y
I
L
A
R
F
D
-------
F
P
G
-
K
R
L
V
E
S
I
I
D
------
V
P
V
V
V
P
H
T
V
A
G
I
A
L
L
T
V
F
G
S
R
-
G
-
L
I
G
E
P
-----
L
-
E
-----
S
Y
I
Q
F
R
D
A
L
P
G
I
V
V
A
M
L
F
V
S
M
P
Y
L
A
--
N
--
S
A
R
E
G
F
K
S
V
-
D
P
R
L
E
N
A
A
R
S
L
G
A
P
L
W
K
A
F
F
F
V
T
L
P
L
S
A
R
Y
L
L
I
G
S
V
M
T
W
A
R
A
I
S
--
E
F
G
A
V
V
I
L
A
Y
Y
-
P
-
M
-
V
-------------
G
P
-
T
L
I
Y
D
R
F
I
----
S
Y
---
G
-
L
S
A
-----
S
R
P
I
A
V
L
----
L
I
L
V
-
T
L
S
I
F
L
V
I
R
-----------------
18
Fugue
68.58
17%
-102
- C4 -
1KC6
3
T2C2_HAEIF
A:
[1-257]
----------------------
S
F
I
K
P
I
Y
Q
D
I
N
-
S
I
L
---------------
I
G
Q
K
V
K
-----
R
P
------
A
A
G
---
E
P
F
E
K
L
V
Y
K
F
-
L
-----
K
E
N
-------
L
S
D
--
L
T
F
K
Q
Y
E
Y
L
N
D
L
-
F
M
K
N
P
A
I
I
G
H
E
A
R
Y
K
L
F
N
S
P
-
T
L
L
F
L
L
S
R
----------
G
K
A
A
T
E
N
-
W
-------------
S
I
E
------
N
L
F
E
-
E
K
Q
N
D
-----------------------
T
A
D
I
L
L
V
K
D
Q
-
F
Y
E
L
L
-----
D
V
K
T
R
N
I
S
K
--
S
A
Q
A
P
N
I
I
S
A
Y
K
L
A
-
Q
T
C
A
K
M
I
--
D
N
K
E
F
D
L
F
D
I
N
Y
L
E
V
D
W
E
L
N
G
---------------------
E
D
L
V
C
V
S
T
S
F
A
E
L
F
K
--
S
E
-
P
S
E
L
Y
I
-
N
-
W
-
A
-
A
-------------
A
M
-
Q
I
Q
F
H
-
V
R
----
D
L
---
D
-
Q
G
F
NGT
R
E
E
W
A
K
S
Y
L
----
K
H
F
V
-
T
Q
A
E
Q
R
A
I
S
M
-
I
D
K
F
V
K
P
F
K
K
Y
-
I
L
-
20
Fugue
65.06
14%
-125
- C4 -
3THI
1
THI1_PANTH
A:
[1-362]
I
T
L
K
V
A
I
YPYVPD
P
A
R
F
Q
A
A
V
L
D
Q
W
Q
R
Q
E
P
G
V
K
-
L
E
F
T
D
W
D
SYSADPPDDLD
V
F
V
L
D
S
I
F
-
L
S
H
F
------
V
D
A
---
G
Y
L
L
P
F
G
S
Q
D
-
I
-----
D
Q
A
E
DV
L
P
F
A
L
Q
G
--
A
K
R
N
G
E
V
Y
G
L
P
Q
-
I
L
C
T
N
L
L
F
Y
R
K
G
D
L
K
I
G
Q
V
D
-
N
I
Y
E
L
Y
K
K
I
G
T
S
H
S
--
E
Q
I
P
P
P
Q
N
K
G
L
L
I
N
M
-
A
G
G
T
T
K
A
S
M
Y
L
------
E
A
L
I
-
D
V
T
G
Q
Y
T
E
Y
D
L
L
P
P
L
D
P
L
N
D
K
V
I
R
G
L
R
L
L
I
N
M
A
G
E
K
P
S
Q
Y
V
P
E
D
-----
G
D
A
Y
V
R
A
S
W
F
A
Q
G
S
G
R
A
F
I
G
Y
-
S
E
S
M
M
R
M
G
D
Y
A
--
E
--
Q
V
R
F
K
P
I
S
S
S
A
G
Q
D
I
P
L
F
Y
S
D
V
V
S
V
N
S
K
T
A
H
P
E
L
A
K
K
L
A
N
V
M
A
S
-----
A
D
T
V
E
--
Q
A
L
R
P
Q
A
D
G
-
Q
-
Y
-
P
-
Q
-------------
Y
L
-
L
P
A
R
H
Q
V
Y
----
E
A
L
MQ
D
-
Y
P
I
-----
Y
S
E
L
A
Q
I
V
N
KP
S
N
R
V
-
F
R
L
G
P
E
V
R
T
W
-
L
K
D
A
K
Q
V
L
P
E
A
-
L
G
-
16
Fugue
53.40
18%
-39
- C5 -
3FMY
-
MQSA_ECOLI
A:
[66-131]
------------------------------------------------------------------------------------
A
E
T
-
V
-----
A
P
E
F
--
I
V
K
V
R
K
K
--
L
S
L
T
Q
K
E
A
S
E
I
F
G
G
G
V
N
A
F
S
R
Y
E
K
G
N
A
P
H
P
S
T
I
-
K
L
L
R
V
L
D
K
H
P
E
L
L
N
--
E
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
45.23
17%
15
* C4 *
3VEJ
-
MDY2_YEAST
A:
[2-41]
----------------------------------------------------------------------------------------------------------------------
V
D
L
-
T
V
P
W
D
D
I
E
A
L
L
K
N
N
F
E
N
D
Q
A
-
A
V
R
Q
V
M
E
R
L
Q
K
G
W
S
--
L
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
45.23
20%
-105
- C4 -
2OD5
7
?
A:
[7-97]
------------------------------------------------------------------------------------------------------------------------------------------
E
T
E
S
M
K
T
V
R
I
R
E
K
I
K
K
F
L
G
D
R
P
R
N
T
A
E
I
L
E
-
H
I
N
S
T
M
R
-
H
G
T
T
S
Q
Q
L
G
------
N
V
L
S
K
D
K
D
I
V
K
V
G
Y
------
I
K
R
S
G
I
L
S
--
G
G
Y
D
I
C
E
W
A
T
R
N
W
-
V
A
E
H
C
-----
P
E
W
T
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
43.78
33%
19
- C3 -
3BS8
-
GSA_BACSU
A:
[24-85]
---------------------------------------------------------------
K
L
------
M
P
G
GVN
S
P
V
R
A
F
K
S
V
D
-
M
-----
D
P
I
F
--
M
E
R
G
K
G
S
K
I
F
D
I
D
G
N
E
Y
I
D
Y
V
-
L
S
W
G
P
L
I
L
G
H
T
N
D
R
V
V
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
42.00
31%
-12
- C5 -
2JFE
-
GBA3_HUMAN
X:
[95-138]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
I
D
Y
Y
N
K
I
I
D
D
L
L
K
N
G
V
T
P
I
V
T
L
Y
H
F
D
L
P
Q
T
L
E
DQ
G
G
W
L
S
E
A
I
----------------------------------------------------------------------------------------------
1
PsiBlast_PDB
41.84
31%
-5
- C5 -
2E9L
3
GBA3_HUMAN
A:
[95-138]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
I
D
Y
Y
N
K
I
I
D
D
L
L
K
N
G
V
T
P
I
V
T
L
Y
H
F
D
L
P
Q
T
L
E
D
Q
G
G
W
L
S
E
A
I
----------------------------------------------------------------------------------------------
2
PsiBlast_PDB
41.18
31%
-8
- C5 -
2E9M
1
GBA3_HUMAN
A:
[95-138]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
I
D
Y
Y
N
K
I
I
D
D
L
L
K
N
G
V
T
P
I
V
T
L
Y
H
F
D
L
P
Q
T
L
E
D
Q
G
G
W
L
S
E
A
I
----------------------------------------------------------------------------------------------
4
PsiBlast_PDB
41.11
31%
-8
- C5 -
3VKK
2
GBA3_HUMAN
A:
[95-138]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
I
D
Y
Y
N
K
I
I
D
D
L
L
K
N
G
V
T
P
I
V
T
L
Y
H
F
D
L
P
Q
T
L
E
D
Q
G
G
W
L
S
E
A
I
----------------------------------------------------------------------------------------------
3
PsiBlast_PDB
40.87
31%
-5
- C5 -
2ZOX
1
GBA3_HUMAN
A:
[95-138]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
I
D
Y
Y
N
K
I
I
D
D
L
L
K
N
G
V
T
P
I
V
T
L
Y
H
F
D
L
P
Q
T
L
E
D
Q
G
G
W
L
S
E
A
I
----------------------------------------------------------------------------------------------
13
HHSearch
26.97
29%
234
- C5 -
1Y66
3
?
A:
[23-46]
----------------------------------------------------------------------------------------------
T
Q
E
T
--
L
H
E
Y
A
Q
K
--
L
G
L
N
Q
Q
A
I
E
Q
F
F
-
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
25.08
6%
40
* C5 *
3TUI
-
METI_ECOLI
A:
[4-38]
--------------------------------------------------------------------------------------------------------------------------------------------------
P
M
M
W
L
L
V
R
G
V
W
--
E
T
L
A
M
T
F
V
S
-
G
F
F
G
F
-
V
-
I
G
L
P
V
G
V
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
23.11
24%
85
- C5 -
3WU2
-
PSBI_THEVL
I:
[8-30]
---------------------------
I
T
V
Y
I
V
-
V
T
F
---------------
F
V
L
L
F
V
F
G
----
F
------
L
S
G
---
D
P
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
13.42
27%
592
- C2 -
1QBF
-
PYY_PIG
A:
[11-21]
--------------------------------------------------------------------------------------
D
-
A
-----
S
P
E
E
--
L
S
R
Y
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------