@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0367: (2016-03-14 )
MTDKKSENQTEKTETKENKGMTRREMLKLSAVAGTGIAVGATGLGTILNVVDQVDKALTPKEKAETGVPFYASNQAGIITAQQTYCYIASFDIQTESRQILQDLFVKWTKFADLTTSGGVLRDVDNDMLPPNDTGEADGLGISNFTVTLGYGPTFFEKDGKDRFGVKAKKPKYLEKIPHMAHDSLDEAYSDGDLCIQVCADDQQVAFHGIRNFIRLASGVAVVRWIEEGFLSAPKNETPRNLFGFKDGTANVDHDSNKGYKDVVWAEKDEPEWMRNGSYLGYRKIQMLIEIWDRSSLLDQEDTFGRKKASGAPYHKKHEHDKVDPSKLPADSHVRLAKDTKQQMHRRAYSYTNGIDKSTGTIDAGLLFICFTQNPAKQFLPMLSIMGKMDKLNEYTVPIGSAMFACQGGLAPGEIFGEKLL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70..-......80.........90.....--.-..100.......-110.......120.......130-........-.-140.......150......-.160.......170..-.....--------180--......--.190.......200.......210.......220.......230---..-----...-----..----..240.......250----.......---------.260...--.-...-----270--.......280.......290...------------....300------........310..--------.....320....-------------------.--------..330----.......---..340------..---.-----..-----....350.......-----360.......370.......380-....-----..-------------.-----------------------390.......400-.......410--........420
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTDKKSENQTEKTETKENKGM
T
R
R
E
M
L
K
L
SAVAGT
G
I
A
VG
A
T
G
L
G
T
I
L
N
V
V
D
Q
V
D
K
ALT
P
K
E
KAETGV
P
F
YAS-NQA
G
I
I
T
-AQ
Q
T
Y
C
Y
I
A
S
F
D
IQ
T
E
--
S
-
R
Q
I
L
Q
D
L
F
V
K
W
T
-KFADLTTSGG
V
L
RDVDNDMLP---PNDTGEAD-G-LGIS
N
F
T
V
T
LGYGP
T
F
FEK-DGKDRFGVKAKK
P
K
Y
L
-
E
KIP
H
--------
M
A
H
--
D
S
L
D
E
A--YSDG
D
L
C
I
Q
VCADD
Q
Q
V
A
F
H
G
I
R
N
F
I
R
L
AS
G
V
A
V
V
R
W
I
E
E
G
F-----LS-----APK-----NE----TPRNLFGFKDGTAN-----VDHDSNK---------GYKD
V
V
W--A-EKD-----
E
P
E
--
W
MRNGSY
L
G
Y
R
K
I
Q
M
L
I
E
I
WDRS------------SLLDQE-------DTFGRKKASGAPY--------HKKHEHDKVDPS-------------------K--------LPA------DS
H
V
R
L
A
---
K
D
T
--------
K
Q
---
Q
-----
M
H
-----
R
R
A
Y
SYTNGIDKST-----GTID
A
G
L
L
F
I
C
FTQ
N
P
A
K
Q
F
L
P
M
-
L
S
I
M
-----GK-------------M-----------------------DKLNEYTVPIG
S
A
-
M
F
A
CQGGLA---
P
G
E
I
FGEKLL-
2
PsiBlast_PDB
98.78
38%
-64
- C2 -
2Y4F
10
EFEB_ECOLI
A:
[14-390]
---------------------------------------------------------
L
S
P
D
A
R
N
E
K
Q
-
P
F
Y
G
E
-
H
Q
A
G
I
L
T
-
P
Q
Q
A
A
M
M
L
V
A
F
D
V
L
A
S
--
D
-
K
A
D
L
E
R
L
F
R
L
L
T
-
Q
R
F
A
F
L
T
Q
G
G
A
A
P
E
T
P
N
P
R
L
P
---
P
L
D
S
G
I
L
G
-
G
Y
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
-----
E
R
F
G
L
A
P
Q
M
P
K
K
L
-
Q
K
M
T
R
--------
F
P
N
--
D
S
L
D
A
A
--
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
-----
I
S
D
H
A
A
R
S
K
G
-----
K
E
----
T
P
I
N
L
L
G
F
K
D
G
T
A
N
-----
P
D
S
Q
N
D
K
---------
L
M
Q
K
V
V
W
VT
A
-
D
Q
Q
-----
E
P
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
------------
P
L
K
E
Q
Q
-------
T
I
F
G
R
D
K
Q
T
G
A
P
L
--------
G
M
Q
H
E
H
D
V
P
D
Y
A
-------------------
S
--------
D
P
E
GKVIAL
D
S
H
I
R
L
A
---
N
P
R
--------
T
A
---
E
S
E
S
S
L
M
L
-----
R
R
G
Y
S
Y
S
L
G
V
T
N
S
------
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
H
D
L
E
K
G
F
L
T
V
-
Q
K
R
L
-----
N
G
-------------------------------------
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
D
---
A
N
D
Y
F
G
S
A
L
L
-
28
HHSearch
98.69
39%
-63
- C2 -
3O72
2
EFEB_ECO57
A:
[13-386]
-------------------------------------------------------------
V
A
R
N
E
K
Q
P
F
Y
G
E
-
H
Q
A
G
I
L
T
-
P
Q
Q
A
A
M
M
L
V
A
F
D
V
L
A
S
--
D
-
K
A
D
L
E
R
L
F
R
L
L
T
-
Q
R
F
A
F
L
T
Q
G
G
A
A
P
E
T
P
N
P
R
L
P
---
P
L
D
S
G
I
L
G
G
Y
-
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
E
-
R
----
F
G
L
A
P
Q
M
P
K
K
L
-
Q
K
M
T
R
--------
F
P
N
--
D
S
L
D
A
A
--
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
-----
I
S
-----
D
H
A
A
R
S
K
G
K
E
----
T
P
I
N
L
L
G
F
K
D
G
T
A
N
-----
P
D
S
Q
N
D
K
---------
L
M
Q
K
V
V
W
--
V
-
T
A
D
QQ---
E
P
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
------------
P
L
K
E
Q
Q
-------
T
I
F
G
R
D
K
Q
T
G
A
P
L
--------
G
M
Q
H
E
H
D
V
P
D
Y
A
-------------------
S
DPEGKG--
I
A
L
------
D
S
H
I
R
L
A
---
N
P
R
TAESE---
S
S
---
L
-----
M
L
-----
R
R
G
Y
S
Y
S
L
G
V
T
N
S
------
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
H
D
L
E
K
G
F
L
T
V
-
Q
K
R
L
-----
N
--------------
G
-----------------------
E
A
L
E
E
Y
V
K
P
I
G
G
G
-
Y
F
F
A
L
P
G
V
K
D--
A
N
D
Y
L
G
S
A
L
L
-
4
PsiBlast_PDB
98.24
38%
-64
- C2 -
2Y4E
5
EFEB_ECOLI
A:
[25-401]
---------------------------------------------------------
L
S
P
D
A
R
N
E
K
Q
-
P
F
Y
G
E
-
H
Q
A
G
I
L
T
-
P
Q
Q
A
A
M
M
L
V
A
F
D
V
L
A
S
--
D
-
K
A
D
L
E
R
L
F
R
L
L
T
-
Q
R
F
A
F
L
T
Q
G
G
A
A
P
E
T
P
N
P
R
L
P
---
P
L
D
S
G
I
L
G
-
G
Y
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
-----
E
R
F
G
L
A
P
Q
M
P
K
K
L
-
Q
K
M
T
R
--------
F
P
N
--
D
S
L
D
A
A
--
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
-----
I
S
D
H
A
A
R
S
K
G
-----
K
E
----
T
P
I
N
L
L
G
F
K
D
G
T
A
N
-----
P
D
S
Q
N
D
K
---------
L
M
Q
K
V
V
W
VT
A
-
D
Q
Q
-----
E
P
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
------------
P
L
K
E
Q
Q
-------
T
I
F
G
R
D
K
Q
T
G
A
P
L
--------
G
M
Q
H
E
H
D
V
P
D
Y
A
-------------------
S
--------
D
P
E
GKVIAL
D
S
H
I
R
L
A
---
N
P
R
--------
T
A
---
E
SESS
L
M
L
-----
R
R
G
Y
S
Y
S
L
G
V
T
N
S
------
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
H
D
L
E
K
G
F
L
T
V
-
Q
K
R
L
-----
N
G
-------------------------------------
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
D
---
A
N
D
Y
F
G
S
A
L
L
-
21
PsiBlast_CBE
98.22
38%
-62
- C2 -
2Y4F
6
EFEB_ECOLI
B:
[14-390]
---------------------------------------------------------
L
S
P
D
A
R
N
E
K
Q
-
P
F
Y
G
E
-
H
Q
A
G
I
L
T
-
P
Q
Q
A
A
M
M
L
V
A
F
D
V
L
A
S
--
D
-
K
A
D
L
E
R
L
F
R
L
L
T
-
Q
R
F
A
F
L
T
Q
G
G
A
A
P
E
T
P
N
P
R
L
P
---
P
L
D
S
G
I
L
G
-
G
Y
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
-----
E
R
F
G
L
A
P
Q
M
P
K
K
L
-
Q
K
M
T
R
--------
F
P
N
--
D
S
L
D
A
A
--
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
-----
I
S
DHAAR
S
K
G
-----
K
E
----
T
P
I
N
L
L
G
F
K
D
G
T
A
N
-----
P
D
S
Q
N
D
K
---------
L
M
Q
K
V
V
W
VT
A
-
D
Q
Q
-----
E
P
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
------------
P
L
K
E
Q
Q
-------
T
I
F
G
R
D
K
Q
T
G
A
P
L
--------
G
M
Q
H
E
H
D
V
P
D
Y
A
-------------------
S
--------
D
P
E
GKVIAL
D
S
H
I
R
L
A
---
N
P
R
--------
T
A
---
E
SESSL
M
L
-----
R
R
G
Y
S
Y
S
L
G
V
T
N
S
------
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
H
D
L
E
K
G
F
L
T
V
-
Q
K
R
L
-----
N
G
-------------------------------------
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
D
---
A
N
D
Y
F
G
S
A
L
L
-
22
PsiBlast_CBE
98.00
38%
-67
- C2 -
2Y4E
3
EFEB_ECOLI
B:
[25-401]
---------------------------------------------------------
L
S
P
D
A
R
N
E
K
Q
-
P
F
Y
G
E
-
H
Q
A
G
I
L
T
-
P
Q
Q
A
A
M
M
L
V
A
F
D
V
L
A
S
--
D
-
K
A
D
L
E
R
L
F
R
L
L
T
-
Q
R
F
A
F
L
T
Q
G
G
A
A
P
E
T
P
N
P
R
L
P
---
P
L
D
S
G
I
L
G
-
G
Y
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
-----
E
R
F
G
L
A
P
Q
M
P
K
K
L
-
Q
K
M
T
R
--------
F
P
N
--
D
S
L
D
A
A
--
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
-----
I
S
DHAAR
S
K
G
-----
K
E
----
T
P
I
N
L
L
G
F
K
D
G
T
A
N
-----
P
D
S
Q
N
D
K
---------
L
M
Q
K
V
V
W
VT
A
-
D
Q
Q
-----
E
P
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
------------
P
L
K
E
Q
Q
-------
T
I
F
G
R
D
K
Q
T
G
A
P
L
--------
G
M
Q
H
E
H
D
V
P
D
Y
A
-------------------
S
--------
D
P
E
GKVIAL
D
S
H
I
R
L
A
---
N
P
R
--------
T
A
---
E
SESSL
M
L
-----
R
R
G
Y
S
Y
S
L
G
V
T
N
S
------
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
H
D
L
E
K
G
F
L
T
V
-
Q
K
R
L
-----
N
G
-------------------------------------
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
D
---
A
N
D
Y
F
G
S
A
L
L
-
3
PsiBlast_PDB
97.80
38%
-65
- C2 -
2Y4D
14
EFEB_ECOLI
A:
[28-401]
------------------------------------------------------------
D
A
R
N
E
K
Q
-
P
F
Y
G
E
-
H
Q
A
G
I
L
T
-
P
Q
Q
A
A
M
M
L
V
A
F
D
V
L
A
S
--
D
-
K
A
D
L
E
R
L
F
R
L
L
T
-
Q
R
F
A
F
L
T
Q
G
G
A
A
P
E
T
P
N
P
R
L
P
---
P
L
D
S
G
I
L
G
-
G
Y
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
-----
E
R
F
G
L
A
P
Q
M
P
K
K
L
-
Q
K
M
T
R
--------
F
P
N
--
D
S
L
D
A
A
--
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
-----
I
S
D
H
A
A
R
S
K
G
-----
K
E
----
T
P
I
N
L
L
G
F
K
D
G
T
A
N
-----
P
D
S
Q
N
D
K
---------
L
M
Q
K
V
V
W
VT
A
-
D
Q
Q
-----
E
P
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
------------
P
L
K
E
Q
Q
-------
T
I
F
G
R
D
K
Q
T
G
A
P
L
--------
G
M
Q
H
E
H
D
V
P
D
Y
A
-------------------
S
--------
D
P
E
GKVIAL
D
S
H
I
R
L
A
---
N
P
---------------SESS
L
M
L
-----
R
R
G
Y
S
Y
S
L
G
V
T
N
S
------
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
H
D
L
E
K
G
F
L
T
V
-
Q
K
R
L
-----
N
G
-------------------------------------
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
D
---
A
N
D
Y
F
G
S
A
L
L
-
23
PsiBlast_CBE
97.55
38%
-65
- C2 -
2Y4D
13
EFEB_ECOLI
B:
[28-401]
------------------------------------------------------------
D
A
R
N
E
K
Q
-
P
F
Y
G
E
-
H
Q
A
G
I
L
T
-
P
Q
Q
A
A
M
M
L
V
A
F
D
V
L
A
S
--
D
-
K
A
D
L
E
R
L
F
R
L
L
T
-
Q
R
F
A
F
L
T
Q
G
G
A
A
P
E
T
P
N
P
R
L
P
---
P
L
D
S
G
I
L
G
-
G
Y
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
-----
E
R
F
G
L
A
P
Q
M
P
K
K
L
-
Q
K
M
T
R
--------
F
P
N
--
D
S
L
D
A
A
--
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
-----
I
S
DHAAR
S
K
G
-----
K
E
----
T
P
I
N
L
L
G
F
K
D
G
T
A
N
-----
P
D
S
Q
N
D
K
---------
L
M
Q
K
V
V
W
VT
A
-
D
Q
Q
-----
E
P
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
------------
P
L
K
E
Q
Q
-------
T
I
F
G
R
D
K
Q
T
G
A
P
L
--------
G
M
Q
H
E
H
D
V
P
D
Y
A
-------------------
S
--------
D
P
E
GKVIAL
D
S
H
I
R
L
A
---
N
P
---------------SESSL
M
L
-----
R
R
G
Y
S
Y
S
L
G
V
T
N
S
------
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
H
D
L
E
K
G
F
L
T
V
-
Q
K
R
L
-----
N
G
-------------------------------------
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
D
---
A
N
D
Y
F
G
S
A
L
L
-
5
PsiBlast_PDB
97.32
37%
-63
- C2 -
3O72
2
EFEB_ECO57
A:
[13-386]
------------------------------------------------------------
V
A
R
N
E
K
Q
-
P
F
Y
G
E
-
H
Q
A
G
I
L
T
-
P
Q
Q
A
A
M
M
L
V
A
F
D
V
L
A
S
--
D
-
K
A
D
L
E
R
L
F
R
L
L
T
-
Q
R
F
A
F
L
T
Q
G
G
A
A
P
E
T
P
N
P
R
L
P
---
P
L
D
S
G
I
L
G
-
G
Y
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
-----
E
R
F
G
L
A
P
Q
M
P
K
K
L
-
Q
K
M
T
R
--------
F
P
N
--
D
S
L
D
A
A
--
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
-----
I
S
D
H
A
A
R
S
K
G
-----
K
E
----
T
P
I
N
L
L
G
F
K
D
G
T
A
N
-----
P
D
S
Q
N
D
K
---------
L
M
Q
K
V
V
W
VT
A
-
D
Q
Q
-----
E
P
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
------------
P
L
K
E
Q
Q
-------
T
I
F
G
R
D
K
Q
T
G
A
P
L
--------
G
M
Q
H
E
H
D
V
P
D
Y
A
-------------------
S
--------
D
P
E
GKGIAL
D
S
H
I
R
L
A
---
N
P
R
--------
T
A
---
E
-----
S
E
SS
L
M
L
R
R
G
Y
S
Y
S
L
G
V
T
N
S
------
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
H
D
L
E
K
G
F
L
T
V
-
Q
K
R
L
-----
N
G
-------------------------------------
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
D
---
A
N
D
Y
L
G
S
A
L
L
-
24
PsiBlast_CBE
92.37
34%
-69
- C2 -
4GT2
5
?
G:
[102-463]
---------------------------------------------------------------------
F
H
G
K
-
H
Q
P
G
I
T
T
-
P
M
Q
A
R
G
H
L
V
A
F
D
L
A
A
G
--
A
G
R
K
E
A
A
A
L
L
R
R
W
S
-
D
T
A
R
R
L
M
A
G
E
P
A
G
S
R
D
T
D
V
-----------
A
R
-
D
-
A
G
P
S
S
L
T
V
T
F
G
F
G
H
S
F
F
------
G
R
T
G
L
E
E
Q
R
P
V
A
L
-
D
P
L
P
D
--------
F
S
S
--
D
H
L
D
K
N
--
R
S
N
G
D
L
W
V
Q
I
G
A
D
D
A
L
V
A
F
H
A
L
R
A
I
Q
R
D
A
G
A
A
A
R
V
R
W
Q
M
N
G
F
-----
N
R
-----
S
P
G
-----
A
T
AHPM
T
A
R
N
L
M
G
Q
V
D
G
T
R
N
PKPGE
A
D
F
D
R
R
I
---------
F
V
P
E
----------------
P
A
--
W
M
A
N
G
S
Y
V
V
V
R
R
I
R
M
L
L
D
D
W
E
E
L
------------
S
L
K
A
Q
E
-------
D
V
I
G
R
R
K
S
D
G
A
P
L
SGGSGATE
S
T
E
M
D
L
E
K
T
D
G
S
-------------------
G
ELV-----
V
P
I
------
N
A
H
A
R
I
T
---
R
P
D
--------
Q
N
GGA
A
-----
M
V
-----
R
R
P
F
S
Y
H
D
G
F
D
-
A
D
-----
G
V
P
D
A
G
L
L
F
V
C
W
Q
A
D
P
L
R
G
F
V
P
V
-
Q
R
K
L
-----
D
R
-------------
G
-----------------------
D
A
L
S
Q
F
I
R
H
E
A
S
G
-
L
F
A
V
P
G
G
A
A
---
E
G
E
Y
V
G
Q
R
L
L
-
26
PsiBlast_CBE
92.19
34%
-63
- C2 -
4GT2
5
?
A:
[102-463]
---------------------------------------------------------------------
F
H
G
K
-
H
Q
P
G
I
T
T
-
P
M
Q
A
R
G
H
L
V
A
F
D
L
A
A
G
--
A
G
R
K
E
A
A
A
L
L
R
R
W
S
-
D
T
A
R
R
L
M
A
G
E
P
A
G
S
R
D
T
D
V
-----------
A
R
-
D
-
A
G
P
S
S
L
T
V
T
F
G
F
G
H
S
F
F
------
G
R
T
G
L
E
E
Q
R
P
V
A
L
-
D
P
L
P
D
--------
F
S
S
--
D
H
L
D
K
N
--
R
S
N
G
D
L
W
V
Q
I
G
A
D
D
A
L
V
A
F
H
A
L
R
A
I
Q
R
D
A
G
A
A
A
R
V
R
W
Q
M
N
G
F
-----
N
R
-----
S
P
G
-----
A
T
A
H
P
M
T
A
R
N
L
M
G
Q
V
D
G
T
R
N
PKPGE
A
D
F
D
R
R
I
---------
F
V
P
E
E
--------------
G
P
A
--
W
M
A
N
G
S
Y
V
V
V
R
R
I
R
M
L
L
D
D
W
E
E
L
------------
S
L
K
A
Q
E
-------
D
V
I
G
R
R
K
S
D
G
A
P
L
SGGSGATE
S
T
E
M
D
L
E
K
T
D
G
S
-------------------
G
ELV-----
V
P
I
------
N
A
H
A
R
I
T
---
R
P
D
--------
Q
N
GG
A
A
-----
M
V
-----
R
R
P
F
S
Y
H
D
G
F
D
-
A
D
-----
G
V
P
D
A
G
L
L
F
V
C
W
Q
A
D
P
L
R
G
F
V
P
V
-
Q
R
K
L
-----
D
R
-------------
G
-----------------------
D
A
L
S
Q
F
I
R
H
E
A
S
G
-
L
F
A
V
P
G
G
A
A
---
E
G
E
Y
V
G
Q
R
L
L
-
6
PsiBlast_PDB
91.62
34%
-68
- C2 -
4GT2
6
?
B:
[102-463]
---------------------------------------------------------------------
F
H
G
K
-
H
Q
P
G
I
T
T
-
P
M
Q
A
R
G
H
L
V
A
F
D
L
A
A
G
--
A
G
R
K
E
A
A
A
L
L
R
R
W
S
-
D
T
A
R
R
L
M
A
G
E
P
A
G
S
R
D
T
D
V
-----------
A
R
-
D
-
A
G
P
S
S
L
T
V
T
F
G
F
G
H
S
F
F
------
G
R
T
G
L
E
E
Q
R
P
V
A
L
-
D
P
L
P
D
--------
F
S
S
--
D
H
L
D
K
N
--
R
S
N
G
D
L
W
V
Q
I
G
A
D
D
A
L
V
A
F
H
A
L
R
A
I
Q
R
D
A
G
A
A
A
R
V
R
W
Q
M
N
G
F
-----
N
R
-----
S
P
G
-----
A
T
A
H
P
M
T
A
R
N
L
M
G
Q
V
D
G
T
R
N
PKPGE
A
D
F
D
R
R
I
---------
F
V
P
E
----------------
P
A
--
W
M
A
N
G
S
Y
V
V
V
R
R
I
R
M
L
L
D
D
W
E
E
L
------------
S
L
K
A
Q
E
-------
D
V
I
G
R
R
K
S
D
G
A
P
L
SGGSGATE
S
T
E
M
D
L
E
K
T
D
G
S
-------------------
G
ELV-----
V
P
I
------
N
A
H
A
R
I
T
---
R
P
D
--------
Q
N
GG
A
A
-----
M
V
-----
R
R
P
F
S
Y
H
D
G
F
D
-
A
D
-----
G
V
P
D
A
G
L
L
F
V
C
W
Q
A
D
P
L
R
G
F
V
P
V
-
Q
R
K
L
-----
D
R
-------------
G
-----------------------
D
A
L
S
Q
F
I
R
H
E
A
S
G
-
L
F
A
V
P
G
G
A
A
---
E
G
E
Y
V
G
Q
R
L
L
-
25
PsiBlast_CBE
91.55
34%
-66
- C2 -
4GT2
5
?
E:
[102-463]
---------------------------------------------------------------------
F
H
G
K
-
H
Q
P
G
I
T
T
-
P
M
Q
A
R
G
H
L
V
A
F
D
L
A
A
G
--
A
G
R
K
E
A
A
A
L
L
R
R
W
S
-
D
T
A
R
R
L
M
A
G
E
P
A
G
S
R
D
T
D
V
-----------
A
R
-
D
-
A
G
P
S
S
L
T
V
T
F
G
F
G
H
S
F
F
------
G
R
T
G
L
E
E
Q
R
P
V
A
L
-
D
P
L
P
D
--------
F
S
S
--
D
H
L
D
K
N
--
R
S
N
G
D
L
W
V
Q
I
G
A
D
D
A
L
V
A
F
H
A
L
R
A
I
Q
R
D
A
G
A
A
A
R
V
R
W
Q
M
N
G
F
-----
N
R
-----
S
P
G
-----
A
T
AHPM
T
A
R
N
L
M
G
Q
V
D
G
T
R
N
PKPGE
A
D
F
D
R
R
I
---------
F
V
P
E
E
P
---------------
A
--
W
M
A
N
G
S
Y
V
V
V
R
R
I
R
M
L
L
D
D
W
E
E
L
------------
S
L
K
A
Q
E
-------
D
V
I
G
R
R
K
S
D
G
A
P
L
SGGSGATE
S
T
E
M
D
L
E
K
T
D
G
S
-------------------
G
ELV-----
V
P
I
------
N
A
H
A
R
I
T
---
R
P
D
--------
Q
N
GGA
A
-----
M
V
-----
R
R
P
F
S
Y
H
D
G
F
D
-
A
D
-----
G
V
P
D
A
G
L
L
F
V
C
W
Q
A
D
P
L
R
G
F
V
P
V
-
Q
R
K
L
-----
D
R
-------------
G
-----------------------
D
A
L
S
Q
F
I
R
H
E
A
S
G
-
L
F
A
V
P
G
G
A
A
---
E
G
E
Y
V
G
Q
R
L
L
-
1
PsiBlast_PDB
89.65
42%
-62
- C2 -
4GRC
2
?
A:
[76-424]
-----------------------------------------------------------------
S
A
V
P
F
H
G
A
-
H
Q
A
G
I
A
T
-
P
V
Q
D
R
L
H
F
A
A
F
D
V
T
T
E
--
D
-
R
A
A
F
V
A
L
L
K
E
W
T
-
A
A
A
R
R
L
T
A
G
H
A
V
G
E
G
A
Y
G
G
L
P
EAP
P
D
D
T
G
E
A
L
-
G
-
L
K
P
S
R
L
T
L
T
I
G
F
G
P
S
L
F
T
------
R
F
G
L
A
D
L
R
P
E
A
L
-
A
D
L
P
K
--------
F
P
G
--
D
N
L
D
R
A
--
R
S
G
G
D
L
C
V
Q
A
C
A
D
D
P
Q
V
A
V
H
A
I
R
N
L
A
R
I
G
F
G
K
V
V
V
R
W
S
Q
L
G
F
GKTS-
S
T
-----
T
P
D
-----
E
Q
----
T
P
R
N
L
L
G
F
K
D
G
T
R
N
-----
I
A
G
T
E
K
D
---------
R
L
D
R
F
V
W
--
A
A
E
K
D
-----
G
T
P
--
W
M
T
G
G
S
Y
L
V
A
R
R
I
R
M
H
I
E
T
W
D
R
A
------------
S
L
Q
E
Q
E
-------
D
V
F
G
R
D
K
G
E
G
A
P
V
--------
G
K
A
K
E
R
D
E
P
F
L
K
-------------------
A
--------
M
K
P
------
D
A
H
V
R
L
A
HPD
S
N
G
--------
G
A
---
T
-----
L
L
-----
R
R
G
Y
S
F
T
D
G
T
D
-----------
D
A
G
L
F
F
L
A
Y
Q
R
D
I
R
T
G
F
V
P
V
-
Q
R
N
L
-----
A
--------------
T
-----------------------
D
A
L
N
E
Y
I
Q
H
V
G
S
A
-
V
F
A
V
P
P
G
V
---------------
7
PsiBlast_PDB
74.36
34%
-45
- C2 -
4GS1
4
?
A:
[99-394]
----------------------------------------------------------------------------------------------------------------------------------------------------
G
-
L
L
P
A
S
L
M
V
T
I
G
I
G
G
S
L
L
E
A
M
D
A
A
D
R
------
R
P
D
A
L
-
A
D
L
P
E
--------
F
A
T
--
D
D
L
R
P
R
--
W
C
G
G
D
L
M
L
Q
V
G
A
E
D
P
M
V
L
A
A
A
V
D
E
L
V
A
A
T
A
P
T
T
T
V
R
W
S
L
R
G
F
R
RTAA
A
A
-----
Q
D
P
-----
D
A
----
T
P
R
N
L
M
G
Q
I
D
G
T
A
N
-----
P
A
Q
D
H
P
L
---------
F
T
R
T
V
T
A
--
P
-
P
A
D
-----
D
P
A
HA
W
M
D
G
G
S
Y
L
V
V
R
R
I
R
M
L
L
D
E
W
R
R
L
------------
D
V
P
D
R
E
-------
R
V
I
G
R
H
L
D
T
G
A
P
L
--------
G
G
E
K
E
T
D
P
V
V
L
T
-------------------
A
RDADGRLV
I
P
E
------
D
A
H
V
R
L
A
NPE
N
N
L
--------
G
A
---
R
-----
M
V
-----
R
R
G
Y
N
Y
D
E
G
W
-
R
D
D
-----
G
V
R
D
A
G
L
L
F
M
A
W
Q
G
N
P
A
T
G
F
V
P
V
Q
R
S
L
V
-----
E
Q
-------------
G
-----------------------
D
A
L
N
R
Y
T
R
H
E
G
S
A
-
L
F
A
V
P
A
A
T
A
DRY
P
G
Q
D
L
V
E
----
27
PsiBlast_CBE
74.06
34%
-44
- C2 -
4GS1
4
?
B:
[99-394]
----------------------------------------------------------------------------------------------------------------------------------------------------
G
-
L
L
P
A
S
L
M
V
T
I
G
I
G
G
S
L
L
E
A
M
D
A
A
D
R
------
R
P
D
A
L
-
A
D
L
P
E
--------
F
A
T
--
D
D
L
R
P
R
--
W
C
G
G
D
L
M
L
Q
V
G
A
E
D
P
M
V
L
A
A
A
V
D
E
L
V
A
A
T
A
P
T
T
T
V
R
W
S
L
R
G
F
RRTAA
A
A
-----
Q
D
P
-----
D
A
----
T
P
R
N
L
M
G
Q
I
D
G
T
A
N
-----
P
A
Q
D
H
P
L
---------
F
T
R
T
V
T
A
--
P
-
P
A
D
-----
D
P
A
HA
W
M
D
G
G
S
Y
L
V
V
R
R
I
R
M
L
L
D
E
W
R
R
L
------------
D
V
P
D
R
E
-------
R
V
I
G
R
H
L
D
T
G
A
P
L
--------
G
G
E
K
E
T
D
P
V
V
L
T
-------------------
A
RDADGRLV
I
P
E
------
D
A
H
V
R
L
A
NPE
N
N
L
--------
G
A
---
R
-----
M
V
-----
R
R
G
Y
N
Y
D
E
G
W
-
R
D
D
-----
G
V
R
D
A
G
L
L
F
M
A
W
Q
G
N
P
A
T
G
F
V
P
V
Q
R
S
L
V
-----
E
Q
-------------
G
-----------------------
D
A
L
N
R
Y
T
R
H
E
G
S
A
-
L
F
A
V
P
A
A
T
A
DRY
P
G
Q
D
L
V
E
----
44
Fugue
70.45
20%
-34
- C2 -
3QNS
8
?
A:
[8-318]
V
A
R
L
A
P
Q
A
V
L
T
P
P
S
---------------------------------------------------------------------
A
A
S
L
F
L
V
L
V
A
G
D
S
D
D
--
D
-
R
A
T
V
C
D
V
I
S
G
--------------
I
D
G
P
L
K
A
V
G
F
---
R
E
L
A
G
----------
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
-
V
S
A
S
------
S
K
P
A
H
L
-
H
P
F
V
P
--------
L
S
G
--
P
V
H
S
A
P
--
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
--------------
R
-----
Y
F
----
D
S
R
D
L
L
G
F
V
D
G
T
E
N
--------
P
T
D
D
---------
D
A
A
D
S
A
L
--
I
-
G
D
E
-----
D
P
D
--
F
-
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
------------
S
T
E
E
Q
E
-------
R
V
I
G
R
T
K
L
E
N
V
E
L
-----------------
D
D
D
-------------------
A
--------
Q
P
S
------
N
S
H
V
T
L
N
---
T
I
V
--------
D
D
---
D
-----
G
V
-----
E
H
D
I
L
R
D
N
M
A
F
G
S
L
-----
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
-
R
R
M
F
LGEPP
G
N
-------------
Y
-----------------------
D
R
V
L
D
F
S
T
A
A
T
G
T
-
L
F
F
V
--------
P
S
R
D
V
L
E
S
L
G
D
30
HHSearch
68.06
20%
-59
- C2 -
3QNS
8
?
A:
[11-316]
-----------------------------------------------------------------------
L
A
-
P
Q
A
V
-
L
T
-
P
P
S
A
A
S
L
F
L
V
L
V
A
G
D
S
D
D
D
-
R
A
T
V
C
D
V
I
S
G
I
D
-
G
P
L
K
A
V
G
F
R
E
--------------------------
L
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
-
V
-----
S
-
A
S
S
K
P
A
H
L
-
H
P
F
V
P
--------
L
S
G
--
P
V
H
S
A
P
--
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
-----
R
Y
-----
F
-------------
D
S
R
D
L
L
G
F
V
D
G
T
E
N
-----
P
T
D
D
------------
D
A
A
D
S
A
L
--
I
-
G
D
------
E
D
P
--
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
------------
S
T
E
E
Q
E
-------
R
V
I
G
R
T
K
L
E
N
V
E
L
--------
D
D
---------
D
-------------------
A
--------
Q
P
S
------
N
S
H
V
T
L
N
---
T
I
V
D
DDG
V
---
E
H
---
D
-----
I
L
-----
R
D
N
M
A
F
G
S
L
G
----------
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
-
A
V
T
E
L
M
-
L
R
R
M
-----
F
L
GEPPGN-------
Y
-----------------------
D
R
V
L
D
F
S
T
A
A
T
G
T
-
L
F
F
V
P
S
R
D
V
---
L
E
S
L
-------
29
HHSearch
67.52
21%
-58
- C2 -
2IIZ
5
?
A:
[8-307]
-----------------------------------------------------------------------
P
R
-
E
Q
L
G
V
C
A
-
E
G
N
L
H
S
V
Y
L
M
F
N
A
N
D
N
--
V
-
E
S
Q
L
R
P
C
I
A
N
V
A
-
Q
Y
I
Y
E
L
T
D
Q
Y
--------------------------
S
D
S
A
F
N
G
F
V
A
I
G
A
N
Y
W
D
S
-
L
------
Y
P
E
S
R
P
E
M
L
-
K
P
F
P
A
--------
M
Q
E
--
G
N
R
E
A
P
--
A
I
E
Y
D
L
F
V
H
L
R
C
D
R
Y
D
I
L
H
L
V
A
N
E
I
S
Q
M
F
E
D
L
V
E
L
V
E
E
E
R
G
F
-----
R
F
-----
M
-------------
D
S
R
D
L
T
G
F
V
D
G
T
E
N
-----
P
K
G
R
------------
H
R
Q
E
V
A
L
--
V
-
G
S
------
E
D
P
--
E
F
K
G
G
S
Y
I
H
V
Q
K
Y
A
H
N
L
S
K
W
H
R
L
------------
P
L
K
K
Q
E
-------
D
I
I
G
R
T
K
Q
D
N
I
E
Y
--------
E
S
---------
E
-------------------
D
--------
K
P
L
------
T
S
H
I
K
R
V
---
N
L
K
DENG
K
---
S
I
---
E
-----
I
L
-----
R
Q
S
M
P
Y
G
S
L
------------
K
E
Q
G
L
M
F
I
S
T
C
R
T
P
-
D
H
F
E
K
M
-
L
H
S
M
-----
V
F
GDGAGN-------
H
-----------------------
D
H
L
M
H
F
T
S
A
L
T
G
S
-
S
F
F
A
P
S
L
D
F
---
L
----------
31
HHSearch
65.49
18%
-58
- C2 -
2GVK
12
?
A:
[10-312]
----------------------------------------------------------------------
G
G
H
I
P
Q
D
V
-
A
G
-
K
Q
G
E
N
V
I
F
I
V
Y
N
L
T
D
S
PD
T
-
V
D
K
V
K
D
V
C
A
N
F
S
-
A
M
I
R
S
M
R
N
R
F
--------------------------
P
D
M
Q
F
S
C
T
M
G
F
G
A
D
A
W
T
R
------
L
F
P
D
K
G
K
P
K
E
L
-
S
T
F
S
E
--------
I
K
G
--
E
K
Y
T
A
V
--
S
T
P
G
D
L
L
F
H
I
R
A
K
Q
M
G
L
C
F
E
F
A
S
I
L
D
E
K
L
K
G
A
V
V
S
V
D
E
T
H
G
F
-----
R
Y
-----
M
-------------
D
G
K
A
I
I
G
F
V
D
G
T
E
N
-----
P
A
V
D
E
-----------
N
P
Y
H
F
A
V
--
I
-
G
E
------
E
D
A
--
D
F
A
G
G
S
Y
V
F
V
Q
K
Y
I
H
D
M
V
A
W
N
A
L
------------
P
V
E
Q
Q
E
-------
K
V
I
G
R
H
K
F
N
D
V
E
L
--------
S
D
---------
E
-------------------
E
--------
K
P
G
------
N
A
H
N
A
V
T
---
N
I
G
D-------
D
L
---
K
-----
I
V
-----
R
A
N
M
P
F
A
N
T
S
K
----------
G
E
Y
G
T
Y
F
I
G
Y
A
S
T
F
-
S
T
T
R
R
M
-
L
E
N
M
-----
F
I
GSPAGN-------
T
-----------------------
D
R
L
L
D
F
S
T
A
I
T
G
T
-
L
F
F
V
P
S
Y
D
L
---
L
----------
32
HHSearch
63.01
16%
-47
- C2 -
3VXJ
5
?
A:
[5-439]
-------------------------------------------------------------------
I
L
P
L
N
N
-
I
Q
G
D
I
L
V
G
M
K
K
Q
K
E
R
F
V
F
F
Q
V
N
D
-----
A
T
S
F
K
T
A
L
K
T
Y
V
P
E
R
I
T
S
A
A
I
L
I
S
--------------------
D
-
P
-
S
Q
Q
P
L
A
F
V
N
L
G
F
S
N
T
G
L
Q
A
-
L
-----
G
---
I
T
D
D
L
G
D
A
Q
F
P
D
GQFADAAN
L
G
D
DL
S
Q
W
V
A
P
FT
G
T
T
I
H
G
V
F
L
I
G
S
D
Q
D
D
F
L
D
Q
F
T
D
D
I
S
S
T
F
G
S
S
I
T
Q
V
Q
A
L
S
G
S
-----
A
R
-----
P
G
D
------
Q
----
A
G
H
E
H
F
G
F
L
D
G
I
S
Q
-----
P
S
V
T
G
W
E
T
T
V
F
PG
Q
A
V
V
P
P
G
I
I
L
--
T
-
G
R
D
GDTGT
R
P
S
--
W
A
L
D
G
S
F
M
A
F
R
H
F
Q
Q
K
V
P
E
F
N
A
Y
T
L
A
N
AIPANSAG
N
L
T
Q
Q
E
G
A
E
F
L
G
A
R
M
F
G
R
W
K
-
S
G
A
P
I
--------
D
L
A
P
T
A
D
D
P
A
L
G
A
DPQRNNNFDYSDTLTDET
R
--------
C
P
F
------
G
A
H
V
R
K
T
---
N
P
R
QDLGGPVD
T
F
---
H
-----
A
M
-----
R
S
S
I
P
Y
G
P
E
T
S
D
A
E
L
A
S
GV
T
A
Q
D
R
G
L
L
F
V
E
Y
Q
S
I
I
G
N
G
F
R
F
Q
-
Q
I
N
W
-----
A
N
NANFPFSKPITPG
I
EPIIGQTTPRTVGGLDPLNQNET
F
T
V
P
L
F
V
I
P
K
G
G
E
-
Y
F
F
L
P
S
I
S
A
---
L
T
A
T
-------