@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1202: (2016-03-22 )
MKKAILVVSFGTSYPETREKTIEACEKRVAHEFPDYTVFRAFTSNKIIKKLKTRDNMHINTPSQALNQLKELGYKEVIIQSLHIISGGEFEKITAQVEKFKPDFDSIIVSQPLLDSMEDYEKAIEAIRHQMPPLKEQEALILMGHGSKHHAFSAYACLDHMLLNEPIYLCAVESYPGLDQVIERLQQADIKKAHLMPFMLVAGDHATNDMASDEENSWKSTLEQAGIQTECHLQGLGENPLIQSQFIDHIHTAIERVKTRG
Atome Classification :
(20 SA)
------------------------------.........10..--------------------.-.-....20........30.---.-----.------.....40........50.......-.60.------------.......70........80....-----------.-----..-.90.......-------------..100-----.------------.--......110.-......120..-.....130------...-.--------....--.----140....------------...-150-.------..----......160--.----.-------.--....170----------..-------------.-------.--------...----..180-.....-...190......--.200.-.....--..210...---....220---.........-230........240--.........250.......260---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------M
K
K
A
I
L
V
V
SFGTS--------------------Y-P-
E
T
R
E
K
T
I
E
A
C
E
K
R
V
A
H
E---F-----P------D
Y
T
V
F
R
A
FTS
N
K
I
I
K
K
L
KTRDN
M
H
-IN
T
P
------------
S
Q
A
L
N
Q
L
K
EL
G
Y
K
E
V
I
I
Q
S
L
H
II-----------S-----GG-
E
F
-
E
K
I
T
A
Q
V
-------------
E
KFK------P------------
D
--
F
D
S
I
I
VSQ
P
L
-
L
D
S
M
E
D
Y
E
K
A
I
-
E
A
I
R
H
Q--------MPP-L--------KEQ
E
--
A
----
L
I
L
M
GHG------------SKH-H---
A
------
F
S
----
A
Y
A
C
L
D
H
M
L
--L----N-------E--
P
I
Y
L
C
------------
A
V-------------E-------S--------YP
G
----
L
D
Q
V
--
I
E
R
L
Q
-
Q
ADI
K
K
AHL
M
P
F
--
M
L
V
-A-GDHAT--NDMASDEE---
N
S
W
K
S
-----
T
L
E
QAGIQ
T
-
E
C
-
H
L
QGLGENP----
L
I
Q
S
Q
F
I
D
H
I
H
T
A
I
E
R
V
KTRG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
98.78
53%
-116
- C4 -
2XWP
2
CBIK_SALTY
A:
[2-258]
-------------------------------
K
K
A
L
L
V
V
S
F
G
T
S
--------------------
Y
-
H
-
D
T
C
E
K
N
I
V
A
C
E
R
D
L
A
A
S
---
C
-----
P
------
D
R
D
L
F
R
A
F
T
S
G
M
I
I
R
K
L
R
Q
R
D
G
I
D
-
I
D
T
P
------------
L
Q
A
L
Q
K
L
A
A
Q
G
Y
Q
D
V
A
I
Q
S
L
H
I
I
-----------
N
-----
G
D
-
E
Y
-
E
K
I
V
R
E
V
-------------
Q
L
L
R
------
P
------------
L
--
F
T
R
L
T
L
G
V
P
L
-
L
S
S
H
N
D
Y
V
Q
L
M
-
Q
A
L
R
Q
Q
--------
M
P
S
-
L
--------
R
Q
T
E
--
K
----
V
V
F
M
G
H
G
------------
A
S
H
-
H
---
A
------
F
A
----
A
Y
A
C
L
D
H
M
M
--
T
A
Q
--
R
-------
F
--
P
A
R
V
G
------------
A
V
-------------
E
-------
S
--------
Y
P
E
----
V
D
I
L
--
I
D
S
L
R
-
D
E
G
V
T
G
V
H
L
M
P
L
--
M
L
V
-
A
-
G
D
H
A
I
--
N
D
M
A
S
D
D
G
---
D
S
W
K
M
-----
R
F
N
A
A
G
I
P
A
-
T
P
-
W
L
S
G
L
G
E
N
P
----
A
I
R
A
M
F
V
A
H
L
H
Q
A
L
N
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
98.75
52%
-118
- C4 -
1QGO
3
CBIK_SALTY
A:
[2-258]
-------------------------------
K
K
A
L
L
V
V
S
F
G
T
S
--------------------
Y
-
H
-
D
T
C
E
K
N
I
V
A
C
E
R
D
L
A
A
S
---
C
-----
P
------
D
R
D
L
F
R
A
F
T
S
G
M
I
I
R
K
L
R
Q
R
D
G
I
D
-
I
D
T
P
------------
L
Q
A
L
Q
K
L
A
A
Q
G
Y
Q
D
V
A
I
Q
S
L
H
I
I
-----------
N
-----
G
D
-
E
Y
-
E
K
I
V
R
E
V
-------------
Q
L
L
R
------
P
------------
L
--
F
T
R
L
T
L
G
V
P
L
-
L
S
S
H
N
D
Y
V
Q
L
M
-
Q
A
L
R
Q
Q
--------
M
P
S
-
L
--------
R
Q
T
E
--
K
----
V
V
F
M
G
H
G
------------
A
S
H
-
H
---
A
------
F
A
----
A
Y
A
C
L
D
H
M
M
--
T
----
A
-------
Q
RF
P
A
R
V
G
------------
A
V
-------------
E
-------
S
--------
Y
P
E
----
V
D
I
L
--
I
D
S
L
R
-
D
E
G
V
T
G
V
H
L
M
P
L
--
M
L
V
-
A
-
G
D
H
A
I
--
N
D
M
A
S
D
D
G
---
D
S
W
K
M
-----
R
F
N
A
A
G
I
P
A
-
T
P
-
W
L
S
G
L
G
E
N
P
----
A
I
R
A
M
F
V
A
H
L
H
Q
A
L
N
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
98.29
52%
-118
- C4 -
2XWP
2
CBIK_SALTY
A:
[2-256]
-------------------------------
K
K
A
L
L
V
V
S
F
G
T
S
--------------------
Y
-
H
-
D
T
C
E
K
N
I
V
A
C
E
R
D
L
A
A
S
---
C
-----
P
------
D
R
D
L
F
R
A
F
T
S
G
M
I
I
R
K
L
R
Q
R
D
G
I
D
-
I
D
T
P
------------
L
Q
A
L
Q
K
L
A
A
Q
G
Y
Q
D
V
A
I
Q
S
L
H
I
I
-----------
N
-----
G
D
-
E
Y
-
E
K
I
V
R
E
V
-------------
Q
L
L
R
------
P
------------
L
--
F
T
R
L
T
L
G
V
P
L
-
L
S
S
H
N
D
Y
V
Q
L
M
-
Q
A
L
R
Q
Q
--------
M
P
S
-
L
--------
R
Q
T
E
--
K
----
V
V
F
M
G
H
G
------------
A
S
H
-
H
---
A
------
F
A
----
A
Y
A
C
L
D
H
M
M
--
T
----
A
-------
Q
RF
P
A
R
V
G
------------
A
V
-------------
E
-------
S
--------
Y
P
E
----
V
D
I
L
--
I
D
S
L
R
-
D
E
G
V
T
G
V
H
L
M
P
L
--
M
L
V
-
A
-
G
D
H
A
I
--
N
D
M
A
S
D
D
G
---
D
S
W
K
M
-----
R
F
N
A
A
G
I
P
A
-
T
P
-
W
L
S
G
L
G
E
N
P
----
A
I
R
A
M
F
V
A
H
L
H
Q
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
97.60
52%
-119
- C4 -
1QGO
3
CBIK_SALTY
A:
[2-256]
-------------------------------
K
K
A
L
L
V
V
S
F
G
T
S
--------------------
Y
-
H
-
D
T
C
E
K
N
I
V
A
C
E
R
D
L
A
A
S
---
C
-----
P
------
D
R
D
L
F
R
A
F
T
S
G
M
I
I
R
K
L
R
Q
R
D
G
I
D
-
I
D
T
P
------------
L
Q
A
L
Q
K
L
A
A
Q
G
Y
Q
D
V
A
I
Q
S
L
H
I
I
-----------
N
-----
G
D
-
E
Y
-
E
K
I
V
R
E
V
-------------
Q
L
L
R
------
P
------------
L
--
F
T
R
L
T
L
G
V
P
L
-
L
S
S
H
N
D
Y
V
Q
L
M
-
Q
A
L
R
Q
Q
--------
M
P
S
-
L
--------
R
Q
T
E
--
K
----
V
V
F
M
G
H
G
------------
A
S
H
-
H
---
A
------
F
A
----
A
Y
A
C
L
D
H
M
M
--
T
----
A
-------
Q
RF
P
A
R
V
G
------------
A
V
-------------
E
-------
S
--------
Y
P
E
----
V
D
I
L
--
I
D
S
L
R
-
D
E
G
V
T
G
V
H
L
M
P
L
--
M
L
V
-
A
-
G
D
H
A
I
--
N
D
M
A
S
D
D
G
---
D
S
W
K
M
-----
R
F
N
A
A
G
I
P
A
-
T
P
-
W
L
S
G
L
G
E
N
P
----
A
I
R
A
M
F
V
A
H
L
H
Q
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
91.79
34%
-122
- C4 -
2XVY
18
CBIKP_DESVH
A:
[9-269]
-------------------------------
K
T
G
I
L
L
V
A
F
G
T
S
--------------------
V
-
E
-
E
A
R
-
P
A
L
D
K
M
G
D
R
V
R
A
A
---
H
-----
P
------
D
I
P
V
R
W
A
Y
T
A
K
M
I
R
A
K
L
R
A
-
E
G
I
A
-
A
P
S
P
------------
A
E
A
L
A
G
M
A
E
E
G
F
T
H
V
A
V
Q
S
L
H
T
I
-----------
P
-----
G
E
-
E
F
-
H
G
L
L
E
T
A
-------------
H
A
F
Q
------
G
LPK---------
G
--
L
T
R
V
S
V
G
L
P
L
-
I
G
T
T
A
D
A
E
A
V
A
-
E
A
L
V
A
S
--------
L
P
A
D
R
--------
K
P
G
E
--
P
----
V
V
F
M
G
H
G
------------
T
P
H
-
P
---
A
------
D
I
----
C
Y
P
G
L
Q
Y
Y
L
W
R
L
----
D
-------
P
--
D
L
L
V
G
------------
T
V
-------------
E
-------
G
--------
S
P
S
----
F
D
N
V
--
M
A
E
L
D
-
V
R
K
A
K
R
V
W
L
M
P
L
--
M
A
V
-
A
-
G
D
H
A
R
--
N
D
M
A
G
D
E
D
---
D
S
W
T
S
-----
Q
L
A
R
R
G
I
E
A
-
K
P
-
V
L
H
G
T
A
E
S
D
----
A
V
A
A
I
W
L
R
H
L
D
D
A
L
A
R
L
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
91.65
34%
-122
- C4 -
2XVZ
16
CBIKP_DESVH
A:
[9-269]
-------------------------------
K
T
G
I
L
L
V
A
F
G
T
S
--------------------
V
-
E
-
E
A
R
-
P
A
L
D
K
M
G
D
R
V
R
A
A
---
H
-----
P
------
D
I
P
V
R
W
A
Y
T
A
K
M
I
R
A
K
L
R
A
-
E
G
I
A
-
A
P
S
P
------------
A
E
A
L
A
G
M
A
E
E
G
F
T
H
V
A
V
Q
S
L
H
T
I
-----------
P
-----
G
E
-
E
F
-
H
G
L
L
E
T
A
-------------
H
A
F
Q
------
G
LPK---------
G
--
L
T
R
V
S
V
G
L
P
L
-
I
G
T
T
A
D
A
E
A
V
A
-
E
A
L
V
A
S
--------
L
P
A
D
R
--------
K
P
G
E
--
P
----
V
V
F
M
G
H
G
------------
T
P
H
-
P
---
A
------
D
I
----
C
Y
P
G
L
Q
Y
Y
L
W
R
L
----
D
-------
P
--
D
L
L
V
G
------------
T
V
-------------
E
-------
G
--------
S
P
S
----
F
D
N
V
--
M
A
E
L
D
-
V
R
K
A
K
R
V
W
L
M
P
L
--
M
A
V
-
A
-
G
D
H
A
R
--
N
D
M
A
G
D
E
D
---
D
S
W
T
S
-----
Q
L
A
R
R
G
I
E
A
-
K
P
-
V
L
H
G
T
A
E
S
D
----
A
V
A
A
I
W
L
R
H
L
D
D
A
L
A
R
L
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
91.33
34%
-123
- C4 -
2XVX
19
CBIKP_DESVH
A:
[9-269]
-------------------------------
K
T
G
I
L
L
V
A
F
G
T
S
--------------------
V
-
E
-
E
A
R
-
P
A
L
D
K
M
G
D
R
V
R
A
A
---
H
-----
P
------
D
I
P
V
R
W
A
Y
T
A
K
M
I
R
A
K
L
R
A
-
E
G
I
A
-
A
P
S
P
------------
A
E
A
L
A
G
M
A
E
E
G
F
T
H
V
A
V
Q
S
L
H
T
I
-----------
P
-----
G
E
-
E
F
-
H
G
L
L
E
T
A
-------------
H
A
F
Q
------
G
LPK---------
G
--
L
T
R
V
S
V
G
L
P
L
-
I
G
T
T
A
D
A
E
A
V
A
-
E
A
L
V
A
S
--------
L
P
A
D
R
--------
K
P
G
E
--
P
----
V
V
F
M
G
H
G
------------
T
P
H
-
P
---
A
------
D
I
----
C
Y
P
G
L
Q
Y
Y
L
W
R
L
----
D
-------
P
--
D
L
L
V
G
------------
T
V
-------------
E
-------
G
--------
S
P
S
----
F
D
N
V
--
M
A
E
L
D
-
V
R
K
A
K
R
V
W
L
M
P
L
--
M
A
V
-
A
-
G
D
H
A
R
--
N
D
M
A
G
D
E
D
---
D
S
W
T
S
-----
Q
L
A
R
R
G
I
E
A
-
K
P
-
V
L
H
G
T
A
E
S
D
----
A
V
A
A
I
W
L
R
H
L
D
D
A
L
A
R
L
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
88.84
35%
-115
- C4 -
2XVY
18
CBIKP_DESVH
A:
[8-267]
------------------------------
Q
K
T
G
I
L
L
V
A
F
G
T
S
--------------------
V
-
E
-
E
A
R
P
-
A
L
D
K
M
G
D
R
V
R
A
A
---
H
-----
P
------
D
I
P
V
R
W
A
Y
T
A
K
M
I
R
A
K
L
R
A
E
G
-
I
A
-
A
P
S
P
------------
A
E
A
L
A
G
M
A
E
E
G
F
T
H
V
A
V
Q
S
L
H
T
I
-----------
P
-----
G
E
-
E
F
-
H
G
L
L
E
T
A
-------------
H
A
F
Q
------
G
LPK---------
G
--
L
T
R
V
S
V
G
L
P
L
I
G
T
T
A
----
D
A
--
E
A
V
A
E
A
--------
L
V
A
-
S
LPADR---
K
P
G
E
--
P
----
V
V
F
M
G
H
G
------------
T
P
H
-
P
---
A
------
D
I
----
C
Y
P
G
L
Q
Y
Y
L
--
W
R
L
--
D
-------
P
--
D
L
L
V
G
------------
T
V
-------------
E
-------
G
--------
S
P
S
----
F
D
N
V
--
M
A
E
L
D
-
V
R
K
A
K
R
V
W
L
M
P
L
--
M
A
V
-
A
-
G
D
H
A
R
--
N
D
M
A
G
D
E
D
---
D
S
W
T
S
-----
Q
L
A
R
R
G
I
E
A
-
K
P
-
V
L
H
G
T
A
E
S
D
----
A
V
A
A
I
W
L
R
H
L
D
D
A
L
A
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
58.57
12%
-89
- C4 -
1DOZ
2
HEMH_BACSU
A:
[1-309]
----------------------------S
R
K
K
M
G
L
L
V
M
A
Y
G
T
P
YKEED
I
E
R
Y
Y
T
H
I
R
R
GRKPE-----------
P
E
M
L
Q
D
L
K
D
R
---
Y
-----
E
A
I
GGI
S
P
L
A
Q
I
T
E
Q
Q
A
H
N
L
E
Q
H
L
N
E
I
Q
D
E
--
I
T
F
K
A
Y
I
G
L
KHIEPF
I
E
D
A
V
A
E
M
H
K
D
G
I
T
E
A
V
S
I
V
L
A
P
H
FSTFS------
V
-----
Q
S
-
Y
N
-
K
R
A
K
E
E
A
-------------
E
K
L
G
-----------------------
G
L
T
I
T
S
V
E
S
-
W
Y
D
E
P
K
F
V
T
Y
W
V
D
R
V
K
E
T
--------
Y
A
S
-
M
--------
P
E
D
E
--
R
E
N
A
M
L
I
V
S
A
H
S
LPEKIKEFGDP
Y
P
D
Q
-
L
---
H
------
E
S
----
A
K
L
I
A
E
G
A
G
--
V
----
S
----------
E
Y
A
V
G
------------
W
Q
-------------
S
-------
E
--------
G
N
T
PDPW
L
G
P
D
--
V
Q
D
L
T
-
R
D
L
F
E
Q
K
G
Y
Q
A
F
--
V
Y
V
-
P
-
V
G
F
V
A
--
D
H
L
E
V
L
Y
D
NDY
E
C
K
-
V
-----
V
T
D
D
I
G
A
-
S
-
Y
Y
-
R
P
E
M
P
N
A
K
P
----
E
F
I
D
A
L
A
T
V
V
L
K
K
L
G
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
56.68
14%
-95
- C4 -
2JH3
-
?
A:
[2-269]
------------------------------
A
L
R
S
L
V
L
I
G
H
G
S
H
--------------------
H
H
G
-
E
S
A
R
-
A
T
Q
Q
V
A
E
A
L
R
G
R
---
G
L
A
GHL
P
------
Y
D
E
V
L
E
G
Y
W
-------------
Q
Q
-
E
P
G
L
------------
R
Q
V
L
R
T
V
A
---
Y
S
D
V
T
V
V
P
V
F
L
S
-----------
E
-----
G
Y
V
T
E
-
T
V
L
P
R
E
L
-------------
G
L
G
H
------
Q
GPVPTG
G
V
V
R
V
L
G
--
G
R
R
V
R
Y
T
R
P
L
-
G
A
H
P
----
G
M
A
-
D
A
I
A
A
Q
--------
A
R
D
-
T
LPEGTD--
P
A
D
V
--
T
----
L
L
L
L
A
A
R
------------
P
-------
G
------
N
A
----
A
L
E
T
H
A
Q
A
L
--
R
E
R
GQ
F
-------
A
--
G
V
E
V
V
------------
L
E
-------------
S
-------
R
E----------------
S
A
VP
L
S
E
W
P
S
R
V
E
A
G
Q
A
V
L
V
P
F
--
L
T
H
-
L
-
G
K
H
A
A
--
E
R
L
Q
Q
A
L
--------
A
-----
Q
A
A
E
R
F
P
Q
A
P
P
L
H
V
G
G
P
V
G
E
H
P
----
A
V
A
E
V
V
L
A
L
A
A
E
G
R
E
D
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
56.05
13%
-82
- C4 -
3HCN
7
HEMH_HUMAN
A:
[62-329]
-------------------------------------
I
G
G
G
S
P
--------------------
I
-
K
-
I
W
T
S
K
Q
G
E
G
M
V
K
L
L
D
E
L
S
PN
T
-----
A
------
P
H
K
Y
Y
I
G
F
R
-------------
Y
V
-
H
P
L
T
------------
E
E
A
I
E
E
M
E
R
D
G
L
E
R
A
I
A
F
T
Q
Y
P
Q
-----------
Y
-----
S
C
S
T
T
-
G
S
S
L
N
A
I
-------------
Y
R
Y
Y
------
N
Q
V
GRK-------
P
--
T
M
K
W
S
T
I
D
R
W
-
P
T
H
H
----
L
L
I
-
Q
C
F
A
D
H
--------
I
L
K
-
E
L
D
H
FPLEK
R
S
E
V
--
V
----
I
L
F
S
A
H
S
------------
L
P
M
-
S
V
V
N
R
------
G
D
P
Y
P
Q
E
V
S
A
T
V
Q
K
V
--
M
E
R
L
E
Y
C------
N
--
P
Y
R
L
V
------------
W
Q
-------------
S
KV-----
G
PMPWL---
G
P
Q
----
T
D
E
S
--
I
K
G
L
C
-
E
R
G
R
K
N
I
L
L
V
P
I
--
A
F
T
-
S
--
D
H
I
E
TL
Y
E
L
D
I
E
Y
-------
S
Q
V
----
L
A
K
E
C
G
V
E
N
-
I
R
-
R
A
E
S
L
N
G
N
P
----
L
F
S
K
A
L
A
D
L
V
H
S
H
I
Q
S
N
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
55.38
12%
-77
- C4 -
1LBQ
-
HEMH_YEAST
A:
[98-361]
-------------------------------------
I
G
G
G
S
P
--------------------
I
-
R
K
W
S
E
Y
-
Q
A
T
E
V
C
K
I
L
D
K
T
---
C
PET--
A
------
P
H
K
P
Y
V
A
F
R
-------------
Y
A
-
K
P
L
T
------------
A
E
T
Y
K
Q
M
L
K
D
G
V
K
K
A
V
A
F
S
Q
Y
P
H
-----------
F
SYST
T
G
S
-
S
I
-
N
E
L
W
R
Q
I
-------------
K
A
L
D
------
S
E-----------
R
--
S
I
S
W
S
V
I
D
R
W
-
P
T
N
E
----
G
L
I
-
K
A
F
S
E
N
--------
I
T
K
-
K
L
Q
E
FPQPV
R
D
K
V
--
V
----
L
L
F
S
A
H
S
------------
L
P
M
-
D
V
--
V
N
TGDA
Y
P
A
----
E
V
A
A
T
V
Y
N
I
--
M
Q
K
L
K
F
K------
N
--
P
Y
R
L
V
------------
W
Q
-------------
S
QVGPKPW
L
--------
G
A
Q
----
T
A
E
I
--
A
E
F
L
G
--
P
K
V
D
G
L
M
F
I
P
I
--
A
F
T
-
S
-
D
H
I
E
T
L-
H
E
I
D
L
G
V
-------
I
G
-----
E
-
S
E
Y
K
--
D
-
K
F
K
R
C
E
S
L
N
G
N
Q
----
T
F
I
E
G
M
A
D
L
V
K
S
H
L
Q
S
N
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
53.19
10%
-80
- C4 -
2H1V
1
HEMH_BACSU
A:
[50-309]
-------------------------------------
I
G
G
I
S
P
--------------------
L
-
A
Q
I
T
E
Q
-
Q
A
H
N
L
E
Q
H
L
N
E
I
---
Q
DE---
I
------
T
F
K
A
Y
I
G
L
A
-------------
H
I
-
E
P
F
I
------------
E
D
A
V
A
E
M
H
K
D
G
I
T
E
A
V
S
I
V
L
A
P
H
-----------
F
-----
S
T
F
S
V
-
Q
S
Y
N
K
R
A
-------------
K
E
E
A
------
E
------------
K
L
G
G
L
T
I
T
S
V
E
S
W
-
Y
D
E
P
----
K
F
V
-
T
Y
W
V
D
R
--------
V
K
E
-
T
Y
A
S
MP
E
D
E
R
E
N
A
--
M
----
L
I
V
S
A
H
S
------------
L
P
E
-
K
I--
K
EF----
G
D
P
Y
P
D
Q
L
H
E
S
A
K
L
I
--
A
E
G
A
G
V
-------
S
--
E
Y
A
V
G
------------
W
Q
-------------
S
-------
E
GNTPDPWL
G
P
D
----
V
Q
D
L
--
T
R
D
L
F
E
Q
K
G
Y
Q
A
F
V
Y
V
P
V
--
G
F
V
-
A
D
H
L
E
V
L
--
Y
D
N
D
Y
E
C
-------
K
V
-----
V
T
D
D
I
G
A
S
--
Y
Y
-
R
P
E
M
P
N
A
K
P
----
E
F
I
D
A
L
A
T
V
V
L
K
K
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
50.36
11%
-45
- C4 -
2JH3
1
?
A:
[1-468]
-----------------------------G
A
L
R
S
L
V
L
I
G
H
G
S
H
--------------------
H
-
H
-
G
E
S
A
R
A
T
Q
Q
V
A
E
A
L
R
G
R
---
G
-----
L
------
A
G
H
L
-----------
P
Y
D
E
V
L
E
G
Y
-
W
Q
Q
E
------------
P
G
L
R
Q
V
L
R
T
V
A
Y
S
D
V
T
V
V
P
V
F
L
S
-----------
E
-----
G
Y
-
V
T
-
E
T
V
L
P
R
E
L
GLGHQGPVPTG
G
V
V
R
V
------
L
------------
G
--
G
R
R
V
R
Y
T
R
P
L
-
G
A
H
P
G
M
A
D
A
I
A
-
A
Q
A
R
D
T
--------
L
P
E
-
G
--------
T
D
P
A
D
V
T
----
L
L
L
L
A
A
R
------------
P
G
N
-
A
---
A
------
L
E
----
T
H
A
Q
A
L
R
E
R
--
G
----
Q
-------
F
--
A
G
V
E
V
------------
V
L
-------------
E
-------
S
--------
R
E
S
----
A
V
P
L
--
S
E
W
P
S
-
R
V
E
A
G
Q
A
V
L
V
P
F
--
L
T
H
-
L
-
G
K
H
A
A
--
E
R
L
Q
Q
A
L
A
---
Q
A
A
E
R
-----
F
P
Q
A
P
P
L
H
V
-
G
----
G
P
V
G
E
H
P
----
A
V
A
E
V
V
L
A
L
A
A
E
G
R
E
D
E
R
G
G
D
I
D
Q
A
H
A
E
A
W
A
A
L
R
H
L
A
E
R
G
G
R
L
GE
V
L
L
T
P
YGG
L
F
E
L
R
HTLDEGRATLD
L
Q
T
V
VT
P
E
G
L
R
D
L
T
ARDEAGRWRPIRTWR
T
L
P
R
G
W
R
A
V
L
S
PAD
L
R
L
G
L
E
L
L
YPA
V
I
E
E
S
Y
A
H
E
H
R
R
L
H
W
T
P
W
M
S
T
A
R
R
QTGTLARVQRAT
P
D
Q
V
D
T
V
A
A
Q
V
C
A
SCLRTRLWAGHTLGQTIFSGVPG
G
L
P
C
AEAC
T
V
L
L
A
A
V
R
D
E
V
G
R
E
41
Fugue
48.71
11%
-71
- C4 -
2PJU
-
PRPR_ECOLI
A:
[11-196]
-------------------------------
K
P
V
I
W
T
V
S
V
T
-------------------------------
R
L
F
E
L
F
R
D
I
S
L
E
---
F
-----
D
------
H
L
A
N
I
T
P
I
Q
L
G
F
-----------------------------
E
K
A
V
T
Y
I
R
K
K
L
A
N
E
R
C
--
D
A
I
I
A
-----------
A
-----
G
S
-
N
G
-
A
Y
L
K
S
R
L
-------------
S
V
--------------------------------
P
V
-
I
L
I
K
P
S
G
Y
D
V
L
-
Q
F
L
A
K
-----------
A
-
G
--------
K
L
T
S
--
S
----
I
G
V
V
T
Y
Q
------------
E
T
I
-
P
---
A
------
L
V
----
A
F
Q
K
T
F
----------
N
-------
L
--
R
L
D
Q
R
------------
S
Y
-------------
I
-------
T
--------
E
E
D
----
A
R
G
Q
--
I
N
E
L
K
-
A
N
G
T
E
----------
A
V
-
V
-
G
A
G
L
I
--
T
D
L
A
E
E
------------------------------
A
G
M
T
G
I
F
----
I
Y
S
A
A
T
V
R
Q
A
F
S
D
A
L
D
M
T
R
M
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
47.51
18%
-74
- C4 -
1TJN
-
CBIX_ARCFU
A:
[1-124]
------------------------------
M
R
R
G
L
V
I
V
G
H
G
S
Q
--------------------
L
-
N
-
H
Y
R
E
-
V
M
E
L
H
R
K
R
I
E
E
S
---
G
-----
A
------
F
D
E
V
K
I
A
F
A
-----------
A
-
R
K
R
R
P
M
P
------------
D
E
A
I
R
E
---
M
N
C
D
I
I
Y
V
V
P
L
F
I
S
-----------
Y
-----
G
L
H
V
T
-
E
D
L
P
D
L
L
-------------
G
F
P
R
G
R
G
I
K
E
G
E
F
----------
E
--
G
K
K
V
V
I
C
E
P
I
-
G
E
D
Y
----
F
V
T
-
Y
A
I
L
N
S
--------
V
F
R
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
47.35
18%
-64
- C4 -
2XWS
-
CBIX_ARCFU
A:
[1-124]
------------------------------
M
R
R
G
L
V
I
V
G
H
G
S
Q
--------------------
L
-
N
-
H
Y
R
E
-
V
M
E
L
H
R
K
R
I
E
E
S
---
G
-----
A
------
F
D
E
V
K
I
A
F
A
-----------
A
-
R
K
R
R
P
M
P
------------
D
E
A
I
R
E
---
M
N
C
D
I
I
Y
V
V
P
L
F
I
S
-----------
Y
-----
G
L
H
V
T
-
E
D
L
P
D
L
L
-------------
G
F
P
R
G
R
G
I
K
E
G
E
F
----------
E
--
G
K
K
V
V
I
C
E
P
I
-
G
E
D
Y
----
F
V
T
-
Y
A
I
L
N
S
--------
V
F
R
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
46.28
12%
-36
- C3 -
3KC2
5
YK50_YEAST
A:
[12-352]
KK
I
A
F
A
F
D
I
DGVLFRGKKPIAG
A
S
D
A
L
K
L
L
N
R
N
K
I
P
Y
I
L
L
T
N
G
--------------------
G
-
G
-
F
S
E
R
A
R
T
E
F
I
S
S
K
L
D
V
D
---
V
-----
S
------
P
L
Q
I
I
Q
S
H
T
P
Y
K
S
L
V
N
--
K
Y
S
R
I
L
-
A
V
G
T
------------
P
S
V
R
G
V
A
E
G
Y
G
F
Q
D
V
V
H
Q
T
D
I
V
R
Y
NRDIAPFSGL
S
-----
D
E
-
Q
V
M
E
Y
S
R
D
I
P
-------------
D
L
T
T
------
K
------------
K
--
F
D
A
V
L
V
F
N
D
P
-
H
D
W
A
A
D
I
Q
I
I
S
-
D
A
I
N
S
E
NGMLNTLR
N
E
K
-
S
--------
G
K
P
S
--
I
----
P
I
Y
F
S
N
Q
------------
D
L
L
-
W
---
A
N
PYK
L
N
R
F
----
G
Q
G
A
F
R
L
L
V
--
R
----
R
-------
L
--
Y
L
E
L
N
GEPLQ
D
Y
T
L
G
K
P
T
K
-------------
L
-------
T
--------
Y
D
F
----
A
H
H
V
--
L
I
D
W
E
-
K
R
L
S
G
T
K
P
S
T
S
P
FH
A
V
F
M
V
-
G
D
N
P
A
--
S
D
I
I
G
A
Q
N
---
Y
G
W
N
S
-----
C
L
V
K
T
G
V
Y
N
-
E
-----
G
D
D
L
K
E
----
C
K
P
T
L
I
V
N
D
V
F
D
A
V
T
K
T
L
E
K
Y
A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
45.95
11%
-91
- C4 -
2XWP
2
CBIK_SALTY
A:
[2-132]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
--
A
----
L
L
V
V
S
F
G
------------
T
S
Y
-
H
D
--
T
------
C
E
K
---
N
I
V
A
C
E
R
D
L
--
A
A
S
C
P
D
-------
R
--
D
L
F
R
A
------------
F
T
S
G
M
I
I
R
K
L
R
Q
R
DG
I
-------
D
--------
I
D
T
----
P
L
Q
A
--
L
Q
K
L
A
-
A
Q
G
Y
Q
D
V
A
I
Q
S
L
--
H
I
I
-
N
-
G
D
E
Y
E
---
K
I
V
R
E
V
--------
Q
-----
L
L
R
P
-
L
F
-
T
-
R
L
T
L
G
V
P
L
L
S
S
H
N
D
Y
V
Q
L
M
Q
A
L
R
Q
Q
M
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
45.35
17%
-85
- C4 -
2JH3
-
?
A:
[2-145]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
R
--
S
----
L
V
L
I
G
H
G
------------
S
H
H
H
G
E--
S
------
A
R
----
A
T
Q
Q
V
A
E
A
L
--
R
G
R
--
G
L
A
GHLPY
D
--
E
V
L
E
G
------------
Y
W
-------------
Q
-------
Q
--------
E
P
G
----
L
R
Q
V
--
L
R
T
V
A
----
Y
S
D
V
T
V
V
P
V
--
F
L
S
-
E
-
G
Y
V
T
E
--
T
V
L
P
R
E
L
G
---
L
G
H
Q
G
PVPTG
G
V
V
R
V
L
G
G
R
-
R
V
R
Y
T
R
P
L
G
A
H
P
----
G
M
A
D
A
I
A
A
Q
A
R
D
T
L
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------