@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1556: (2016-03-26 )
MKRKIIVGSRRSKLALTQSNWVINKLKENYPEFDFEIKEIVTKGDRILDVTLSKVGGKGLFVSEVEQALSDEAIDFAVHSMKDVPSSLKEGLIIGAIPKRESPLDCFVFNQVNSLDELPQGSVIGTSSLRRAAQLLKHRPDFVIKPIRGNIDTRLQKLHAENFDAIILAKAGLARMGWLENTTLKLEDIPPEVCLPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKLNGGCEIPIAGFATRANEFVQFKGLVGNADGSIILESEQVGANPSEIGNKVAEDLLSEGADTIIKELRNV
Atome Classification :
(20 SA)
-------.........10.---.......20........30..----......40........50...-----------------.....60---------........70---------.........80..-..-.-...90----..-----------.--.....100.......---------------------110---.......120..----.------....----130.......----.-------140---.....-...---------150......-.160.......--.-170.......180-.....--...190...--....200.......210.......220-.......-------..230.......-240.......250---........-.260........270.....--.-------------------------------.280-........290....-------------------------...300--.........-----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------MK
R
K
I
I
VGSRR
S
---
K
L
A
LTQS
N
W
V
I
N
K
L
K
E
NYPEF----D
F
E
I
K
E
I
VTKG
D
R
I
L
D
V
T
L
S
K-----------------VGGKGL
F
---------
V
S
E
V
E
Q
A
LS----------D
E
A
I
D
F
A
V
H
S
M
K
D
-
V
P
-
S
-
S
L
KE
G
----
L
I
-----------
I
--
G
AIPKRESPL
D
C
F
V
F---------------------NQV---
N
S
L
D
ELPQGSVI----
G
------
T
S
S
L
----
R
R
-
A
A
Q
L
L
K
H----R-------P
D
----
F
V
I
KP-IRG---------
N
I
D
T
R
L
Q
K
L
-
H
A-ENF
D
A
I
I
L
--A-KAG
L
A
RMGWLEN--
T
T
L
K
L--EDI
P
P
E
VCL--PAVGQ
G
A
L
A
I
E
CRES
D
Q
Q
I
R
D
M
L
T
S
---
I
HHEET
G
-------
I
C
V
E
A
E
R
V
F
L
K
K-LNGGCEIPIAG-----FATRAN
E
F
-
V
Q
-
F
KGLVGNAD
G
S
I
I
L
ESE--Q-------------------------------VGA--
N
P
S
E
I
G
N
K
V
A
E
D
L
L
S-------------------------E
G
A
D
----
T
I
I
K
E
L
RNV-----------
2
PsiBlast_PDB
97.61
56%
-87
- C5 -
4MLV
2
?
A:
[4-307]
---------
R
K
I
I
V
G
S
R
R
S
---
K
L
A
L
T
Q
T
K
W
V
I
E
Q
L
K
K
Q
G
L
P
F
----
E
F
E
I
K
E
M
V
-----------------------------------------------
K
E
I
E
Q
A
M
L
----------
D
K
E
I
D
M
A
V
H
S
M
K
D
-
M
P
-
A
-
V
L
P
E
G
----
L
T
-----------
I
--
G
C
I
P
L
R
E
D
H
R
D
A
L
I
S
---------------------
K
N
G
---
E
R
F
E
E
L
P
S
G
A
V
I
----
G
------
T
S
S
L
----
R
R
-
G
A
Q
L
L
S
M
----
R
-------
S
D
----
I
E
I
K
W
-
I
R
G
---------
N
I
D
T
R
L
E
K
L
-
K
N
-
E
D
Y
D
A
I
I
L
--
A
-
A
A
G
L
S
R
M
G
W
S
K
D
--
T
V
T
Q
Y
----
L
E
P
E
I
S
V
--
P
A
V
G
Q
G
A
L
A
I
E
C
R
E
N
D
H
E
L
L
S
L
L
Q
A
---
L
N
H
D
E
T
A
-------
R
A
V
R
A
E
R
V
F
L
K
E
-
M
E
G
G
C
Q
V
P
I
A
G
-----
Y
G
R
I
L
D
G
G
N
I
E
-
L
T
S
L
V
A
S
P
D
G
K
T
I
Y
K
E
H
--
I
-------------------------------
T
G
K
--
D
P
I
A
I
G
S
E
A
A
E
R
L
T
S
-------------------------
Q
G
A
K
----
L
L
I
D
R
V
K
-------------
1
PsiBlast_PDB
96.70
56%
-87
- C5 -
4MLQ
2
?
A:
[4-307]
---------
R
K
I
I
V
G
S
R
R
S
---
K
L
A
L
T
Q
T
K
W
V
I
E
Q
L
K
K
Q
G
L
P
F
----
E
F
E
I
K
E
M
V
-----------------------------------------------
K
E
I
E
Q
A
M
L
----------
D
K
E
I
D
M
A
V
H
S
M
K
D
-
M
P
-
A
-
V
L
P
E
G
----
L
T
-----------
I
--
G
C
I
P
L
R
E
D
H
R
D
A
L
I
S
---------------------
K
N
G
---
E
R
F
E
E
L
P
S
G
A
V
I
----
G
------
T
S
S
L
----
R
R
-
G
A
Q
L
L
S
M
----
R
-------
S
D
----
I
E
I
K
W
-
I
R
G
---------
N
I
D
T
R
L
E
K
L
-
K
N
-
E
D
Y
D
A
I
I
L
--
A
-
A
A
G
L
S
R
M
G
W
S
K
D
--
T
V
T
Q
Y
----
L
E
P
E
I
S
V
--
P
A
V
G
Q
G
A
L
A
I
E
C
R
E
N
D
H
E
L
L
S
L
L
Q
A
---
L
N
H
D
E
T
A
-------
R
A
V
R
A
E
R
V
F
L
K
E
-
M
E
G
G
C
Q
V
P
I
A
G
-----
Y
G
R
I
L
D
G
G
N
I
E
-
L
T
S
L
V
A
S
P
D
G
K
T
I
Y
K
E
H
--
I
-------------------------------
T
G
K
--
D
P
I
A
I
G
S
E
A
A
E
R
L
T
S
-------------------------
Q
G
A
K
----
L
L
I
D
R
V
K
-------------
15
HHSearch
95.97
45%
-84
- C5 -
3ECR
1
HEM3_HUMAN
A:
[21-359]
--------
M
R
V
I
R
V
G
T
R
K
S
---
Q
L
A
R
I
Q
T
D
S
V
V
A
T
L
K
A
S
Y
P
G
L
----
Q
F
E
I
I
A
M
------------------------------------
L
F
---------
T
K
E
L
E
H
A
L
E
----------
K
N
E
V
D
L
V
V
H
S
L
K
D
-
L
P
-
T
-
V
L
P
P
G
----
F
T
-----------
I
--
G
A
I
C
K
R
E
N
P
H
D
A
V
V
F
---------------------
H
P
K
FVG
K
T
L
E
T
L
P
E
K
S
V
V
----
G
------
T
S
S
L
----
R
R
-
A
A
Q
L
Q
R
K
----
F
-------
P
H
----
L
E
F
R
S
-
I
R
G
---------
N
L
N
T
R
L
R
K
L
-
D
E
Q
Q
E
F
S
A
I
I
L
--
A
-
T
A
G
L
Q
R
M
G
W
H
N
R
--
V
G
Q
I
-----
L
H
P
E
E
C
M
--
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
---
L
H
D
P
E
T
L
-------
L
R
C
I
A
E
R
A
F
L
R
H
-
L
E
--
C
S
V
P
V
A
V
-----
H
T
A
M
K
D
G
Q
-
L
Y
-
L
T
G
G
V
W
S
L
D
G
S
D
S
I
Q
E
T
--
M
Q
A
T
I
H
VPAQHEDGPEDDPQLVGITARNIP
R
G
P
Q
L
--
A
A
Q
N
L
G
I
S
L
A
N
L
L
L
S
-------------------------
K
G
A
K
----
N
I
L
D
V
A
R
Q
------------
5
PsiBlast_PDB
93.11
47%
-77
- C5 -
1PDA
2
HEM3_ECOLI
A:
[8-307]
-------------
I
A
T
R
Q
S
---
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
G
L
----
V
V
E
L
V
P
M
V
T
R
G
D
V
I
--------------------------
G
K
G
L
F
---------
V
K
E
L
E
V
A
L
L
----------
E
N
R
A
D
I
A
V
H
S
M
K
D
-
V
P
-
V
-
E
F
P
Q
G
----
L
G
-----------
L
--
V
T
I
C
E
R
E
D
P
R
D
A
F
V
S
---------------------
N
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
----
G
------
T
S
S
L
----
R
R
-
Q
C
Q
L
A
E
R
----
R
-------
P
D
----
L
I
I
R
S
-
L
R
G
---------
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
--
A
-
V
A
G
L
K
R
L
G
L
E
S
R
--
I
R
A
A
L
-----
P
P
E
I
S
L
--
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
---
L
N
H
H
E
T
A
-------
L
R
V
T
A
E
R
A
M
N
T
R
-
L
E
G
A
C
Q
V
P
I
G
S
-----
Y
A
E
L
I
D
G
E
-
I
W
-
L
R
G
L
V
G
A
P
D
G
S
Q
I
I
R
G
E
--
R
-------------------------------
R
G
A
PQ
D
A
E
Q
M
G
I
S
L
A
E
E
L
L
N
-------------------------
N
G
A
R
----
E
I
L
A
E
V
Y
-------------
14
HHSearch
92.78
46%
-86
- C5 -
1GTK
1
HEM3_ECOLI
A:
[3-307]
--------
D
N
V
L
R
I
A
T
R
Q
S
---
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
G
L
----
V
V
E
L
V
P
M
V
----------------------------------
G
L
F
---------
V
K
E
L
E
V
A
L
L
----------
E
N
R
A
D
I
A
V
H
S
M
K
D
-
V
P
-
V
-
E
F
P
Q
G
----
L
G
-----------
L
--
V
T
I
C
E
R
E
D
P
R
D
A
F
V
S
---------------------
N
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
----
G
------
T
S
S
L
----
R
R
-
Q
C
Q
L
A
E
R
----
R
-------
P
D
----
L
I
I
R
S
-
L
R
G
---------
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
--
A
-
V
A
G
L
K
R
L
G
L
E
S
R
--
I
R
A
A
-----
L
P
P
E
I
S
L
--
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
---
L
N
H
H
E
T
A
-------
L
R
V
T
A
E
R
A
M
N
T
R
-
L
E
G
G
C
Q
V
P
I
G
S
-----
Y
A
E
L
I
D
G
E
-
I
W
-
L
R
A
L
V
G
A
P
D
G
S
Q
I
I
R
G
E
R
R
G
-------------------------------
A
P
Q
--
D
A
E
Q
M
G
I
S
L
A
E
E
L
L
N
-------------------------
N
G
A
R
----
E
I
L
A
E
V
Y
-------------
4
PsiBlast_PDB
92.64
47%
-82
- C5 -
1GTK
1
HEM3_ECOLI
A:
[8-308]
-------------
I
A
T
R
Q
S
---
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
G
L
----
V
V
E
L
V
P
M
V
----------------------------------
G
L
F
---------
V
K
E
L
E
V
A
L
L
----------
E
N
R
A
D
I
A
V
H
S
M
K
D
-
V
P
-
V
-
E
F
P
Q
G
----
L
G
-----------
L
--
V
T
I
C
E
R
E
D
P
R
D
A
F
V
S
---------------------
N
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
----
G
------
T
S
S
L
----
R
R
-
Q
C
Q
L
A
E
R
----
R
-------
P
D
----
L
I
I
R
S
-
L
R
G
---------
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
--
A
-
V
A
G
L
K
R
L
G
L
E
S
R
--
I
R
A
A
L
-----
P
P
E
I
S
L
--
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
---
L
N
H
H
E
T
A
-------
L
R
V
T
A
E
R
A
M
N
T
R
-
L
E
G
G
C
Q
V
P
I
G
S
-----
Y
A
E
L
I
D
G
E
-
I
W
-
L
R
A
L
V
G
A
P
D
G
S
Q
I
I
R
G
E
--
R
-------------------------------
R
G
A
PQ
D
A
E
Q
M
G
I
S
L
A
E
E
L
L
N
-------------------------
N
G
A
R
----
E
I
L
A
E
V
Y
N
------------
6
PsiBlast_PDB
92.38
47%
-81
- C5 -
1YPN
1
HEM3_ECOLI
A:
[8-306]
-------------
I
A
T
R
Q
S
---
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
G
L
----
V
V
E
L
V
P
M
V
T
R
G
D
V
---------------------------
G
Q
G
L
F
---------
V
K
E
L
E
V
A
L
L
----------
E
N
R
A
D
I
A
V
H
S
M
K
D
-
V
P
-
V
-
E
F
P
Q
G
----
L
G
-----------
L
--
V
T
I
C
E
R
E
D
P
R
D
A
F
V
S
---------------------
N
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
----
G
------
T
S
S
L
----
R
R
-
Q
C
Q
L
A
E
R
----
R
-------
P
D
----
L
I
I
R
S
-
L
R
G
---------
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
--
A
-
V
A
G
L
K
R
L
G
L
E
S
R
--
I
R
A
A
L
-----
P
P
E
I
S
L
--
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
---
L
N
H
H
E
T
A
-------
L
R
V
T
A
E
R
A
M
N
T
R
-
L
E
G
G
C
Q
V
P
I
G
S
-----
Y
A
E
L
I
D
G
E
-
I
W
-
L
R
A
L
V
G
A
P
D
G
S
Q
I
I
R
G
E
--
R
-------------------------------
R
G
A
PQ
D
A
E
Q
M
G
I
S
L
A
E
E
L
L
N
-------------------------
N
G
A
R
----
E
I
L
A
E
V
--------------
7
PsiBlast_PDB
92.06
47%
-79
- C5 -
1AH5
1
HEM3_ECOLI
A:
[8-308]
-------------
I
A
T
R
Q
S
---
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
G
L
----
V
V
E
L
V
P
M
V
T
R
G
D
-----------------------------
K
G
L
F
---------
V
K
E
L
E
V
A
L
L
----------
E
N
R
A
D
I
A
V
H
S
M
K
D
-
V
P
-
V
-
E
F
P
Q
G
----
L
G
-----------
L
--
V
T
I
C
E
R
E
D
P
R
D
A
F
V
S
---------------------
N
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
----
G
------
T
S
S
L
----
R
R
-
Q
C
Q
L
A
E
R
----
R
-------
P
D
----
L
I
I
R
S
-
L
R
G
---------
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
--
A
-
V
A
G
L
K
R
L
G
L
E
S
R
--
I
R
A
A
L
-----
P
P
E
I
S
L
--
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
---
L
N
H
H
E
T
A
-------
L
R
V
T
A
E
R
A
M
N
T
R
-
L
E
G
G
C
Q
V
P
I
G
S
-----
Y
A
E
L
I
D
G
E
-
I
W
-
L
R
A
L
V
G
A
P
D
G
S
Q
I
I
R
G
E
--
R
-------------------------------
R
G
A
PQ
D
A
E
Q
M
G
I
S
L
A
E
E
L
L
N
-------------------------
N
G
A
R
----
E
I
L
A
E
V
Y
N
------------
3
PsiBlast_PDB
91.67
47%
-82
- C5 -
2YPN
1
HEM3_ECOLI
A:
[8-308]
-------------
I
A
T
R
Q
S
---
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
G
L
----
V
V
E
L
V
P
M
V
----------------------------------
G
L
F
---------
V
K
E
L
E
V
A
L
L
----------
E
N
R
A
D
I
A
V
H
S
M
K
D
-
V
P
-
V
-
E
F
P
Q
G
----
L
G
-----------
L
--
V
T
I
C
E
R
E
D
P
R
D
A
F
V
S
---------------------
N
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
----
G
------
T
S
S
L
----
R
R
-
Q
C
Q
L
A
E
R
----
R
-------
P
D
----
L
I
I
R
S
-
L
R
G
---------
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
--
A
-
V
A
G
L
K
R
L
G
L
E
S
R
--
I
R
A
A
L
-----
P
P
E
I
S
L
--
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
---
L
N
H
H
E
T
A
-------
L
R
V
T
A
E
R
A
M
N
T
R
-
L
E
G
G
C
Q
V
P
I
G
S
-----
Y
A
E
L
I
D
G
E
-
I
W
-
L
R
A
L
V
G
A
P
D
G
S
Q
I
I
R
G
E
--
R
-------------------------------
R
G
A
PQ
D
A
E
Q
M
G
I
S
L
A
E
E
L
L
N
-------------------------
N
G
A
R
----
E
I
L
A
E
V
Y
N
------------
10
PsiBlast_PDB
89.17
42%
-74
- C5 -
4HTG
2
HEM3_ARATH
A:
[13-304]
-----------
I
R
I
G
T
R
G
S
---
P
L
A
L
A
Q
A
Y
E
T
R
E
K
L
K
K
K
H
P
E
L
VEDG
A
I
H
I
E
I
I
K
T
T
G
D
K
I
L
S
Q
P
L
A
D
-----------------
I
G
G
K
G
L
F
---------
T
K
E
I
D
E
A
L
I
----------
N
G
H
I
D
I
A
V
H
S
M
K
D
-
V
P
-
T
-
Y
L
P
E
K
----
T
I
-----------
L
--
P
C
N
L
P
R
E
D
V
R
D
A
F
I
C
---------------------
L
T
A
---
A
T
L
A
E
L
P
A
G
S
V
V
----
G
------
T
A
S
L
----
R
R
-
K
S
Q
I
L
H
K
----
Y
-------
P
A
----
L
H
V
E
E
N
F
R
G
---------
N
V
Q
T
R
L
S
K
L
-
Q
G
-
G
K
V
Q
A
T
L
L
--
A
-
L
A
G
L
K
R
L
S
M
T
E
N
VA
S
I
L
S
L
--
D
E
M
-----
L
--
P
A
V
A
Q
G
A
I
G
I
A
C
R
T
D
D
D
K
M
A
T
Y
L
A
S
---
L
N
H
E
E
T
R
-------
L
A
I
S
C
E
R
A
F
L
E
T
-
L
D
G
S
C
R
T
P
I
A
G
-----
Y
A
S
K
D
E
E
G
N
C
I
-
F
R
G
L
V
A
S
P
D
G
T
K
V
L
E
T
------------------------------------------
S
R
K
G
P
Y
V
Y
E
D
M
V
K
-------------------------
M
G
K
D
------------------------
9
PsiBlast_PDB
86.59
46%
-89
- C5 -
3EQ1
4
HEM3_HUMAN
A:
[19-293]
---------
R
V
I
R
V
G
T
R
K
S
---
Q
L
A
R
I
Q
T
D
S
V
V
A
T
L
K
A
S
Y
P
G
L
----
Q
F
E
I
I
A
--------------------------------------
F
---------
T
K
E
L
E
H
A
L
E
----------
K
N
E
V
D
L
V
V
H
S
L
K
D
-
L
P
-
T
-
V
L
P
P
G
----
F
T
-----------
I
--
G
A
I
C
K
R
E
N
P
H
D
A
V
V
F
---------------------
H
P
K
FVG
K
T
L
E
T
L
P
E
K
S
V
V
----
G
------
T
S
S
L
----
R
R
-
A
A
Q
L
Q
R
K
----
F
-------
P
H
----
L
E
F
R
S
-
I
Q
G
---------
N
L
N
T
R
L
R
K
L
D
E
Q
-
Q
E
F
S
A
I
I
L
--
A
-
T
A
G
L
Q
R
M
G
W
H
N
R
--
V
G
Q
I
L
--
H
---
P
E
E
C
M
--
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
---
L
H
D
P
E
T
L
-------
L
R
C
I
A
E
R
A
F
L
R
H
-
L
E
G
G
C
S
V
P
V
A
V
-----
H
T
A
M
K
D
G
Q
-
L
Y
-
L
T
G
G
V
W
S
L
D
G
S
-----------------------------------------------------------------------------------------------------------------
13
PsiBlast_CBE
86.33
46%
-89
- C5 -
3EQ1
5
HEM3_HUMAN
B:
[19-293]
---------
R
V
I
R
V
G
T
R
K
S
---
Q
L
A
R
I
Q
T
D
S
V
V
A
T
L
K
A
S
Y
P
G
L
----
Q
F
E
I
I
A
--------------------------------------
F
---------
T
K
E
L
E
H
A
L
E
----------
K
N
E
V
D
L
V
V
H
S
L
K
D
-
L
P
-
T
-
V
L
P
P
G
----
F
T
-----------
I
--
G
A
I
C
K
R
E
N
P
H
D
A
V
V
F
---------------------
H
P
K
FVG
K
T
L
E
T
L
P
E
K
S
V
V
----
G
------
T
S
S
L
----
R
R
-
A
A
Q
L
Q
R
K
----
F
-------
P
H
----
L
E
F
R
S
-
I
Q
G
---------
N
L
N
T
R
L
R
K
L
D
E
Q
-
Q
E
F
S
A
I
I
L
--
A
-
T
A
G
L
Q
R
M
G
W
H
N
R
--
V
G
Q
I
L
--
H
---
P
E
E
C
M
--
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
---
L
H
D
P
E
T
L
-------
L
R
C
I
A
E
R
A
F
L
R
H
-
L
E
G
G
C
S
V
P
V
A
V
-----
H
T
A
M
K
D
G
Q
-
L
Y
-
L
T
G
G
V
W
S
L
D
G
S
-----------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
85.40
47%
-87
- C5 -
3ECR
1
HEM3_HUMAN
A:
[22-291]
---------
R
V
I
R
V
G
T
R
K
S
---
Q
L
A
R
I
Q
T
D
S
V
V
A
T
L
K
A
S
Y
P
G
L
----
Q
F
E
I
I
A
M
------------------------------------
L
F
---------
T
K
E
L
E
H
A
L
E
----------
K
N
E
V
D
L
V
V
H
S
L
K
D
-
L
P
-
T
-
V
L
P
P
G
----
F
T
-----------
I
--
G
A
I
C
K
R
E
N
P
H
D
A
V
V
F
---------------------
H
P
K
FVG
K
T
L
E
T
L
P
E
K
S
V
V
----
G
------
T
S
S
L
----
R
R
-
A
A
Q
L
Q
R
K
----
F
-------
P
H
----
L
E
F
R
S
-
I
R
G
---------
N
L
N
T
R
L
R
K
L
D
E
Q
-
Q
E
F
S
A
I
I
L
--
A
-
T
A
G
L
Q
R
M
G
W
H
N
R
--
V
G
Q
I
L
--
H
---
P
E
E
C
M
--
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
---
L
H
D
P
E
T
L
-------
L
R
C
I
A
E
R
A
F
L
R
H
-
L
E
--
C
S
V
P
V
A
V
-----
H
T
A
M
K
D
G
Q
-
L
Y
-
L
T
G
G
V
W
S
L
D
G
S
-----------------------------------------------------------------------------------------------------------------
12
PsiBlast_CBE
84.84
47%
-83
- C5 -
3ECR
1
HEM3_HUMAN
B:
[22-303]
---------
R
V
I
R
V
G
T
R
K
S
---
Q
L
A
R
I
Q
T
D
S
V
V
A
T
L
K
A
S
Y
P
G
L
----
Q
F
E
I
I
A
M
-------------
K
-----------------
I
G
E
K
S
L
F
---------
T
K
E
L
E
H
A
L
E
----------
K
N
E
V
D
L
V
V
H
S
L
K
D
-
L
P
-
T
-
V
L
P
P
G
----
F
T
-----------
I
--
G
A
I
C
K
R
E
N
P
H
D
A
V
V
F
---------------------
H
P
K
FVG
K
T
L
E
T
L
P
E
K
S
V
V
----
G
------
T
S
S
L
----
R
R
-
A
A
Q
L
Q
R
K
----
F
-------
P
H
----
L
E
F
R
S
-
I
R
G
---------
N
L
N
T
R
L
R
K
L
D
E
Q
-
Q
E
F
S
A
I
I
L
--
A
-
T
A
G
L
Q
R
M
G
W
H
N
R
--
V
G
Q
I
L
--
H
---
P
E
E
C
M
--
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
---
L
H
D
P
E
T
L
-------
L
R
C
I
A
E
R
A
F
L
R
H
-
L
E
--
C
S
V
P
V
A
V
-----
H
T
A
M
K
D
G
Q
-
L
Y
-
L
T
G
G
V
W
S
L
D
G
S
-----------------------------------------------------------------------------------------------------------------
34
Fugue
78.72
49%
-80
- C5 -
1PDA
2
?
?:
[3-219]
--------
D
N
V
L
R
I
A
T
R
Q
S
---
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
G
L
----
V
V
E
L
V
P
M
V
T
R
G
D
V
--------------------------
I
G
K
G
L
F
---------
V
K
E
L
E
V
A
L
L
----------
E
N
R
A
D
I
A
V
H
S
M
K
D
-
V
P
-
V
-
E
F
P
Q
G
----
L
G
-----------
L
--
V
T
I
C
E
R
E
D
P
R
D
A
F
V
S
---------------------
N
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
----
G
------
T
S
S
L
----
R
R
-
Q
C
Q
L
A
E
R
----
R
-------
P
D
----
L
I
I
R
S
-
L
R
G
---------
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
--
A
-
V
A
G
L
K
R
L
G
L
E
S
R
--
I
R
-----
A
A
L
P
P
E
I
S
L
--
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
---
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
55.36
22%
-67
- C4 -
4UOX
9
PAT_ECOLI
A:
[7-459]
SAS
A
L
A
C
S
A
H
A
L
N
L
I
E
K
R
T
LD
H
E
E
M
K
A
L
N
R
E
V
I
E
Y
F
K
E
H
V
N
P
G
----
F
L
E
Y
R
K
S
V
T
A
G
G
D
Y
G
A
V
E
W
Q
A
GSLN
T
L
V
D
TQGQEFIDC
L
G
G
F
G
I
F
NVGHRN
P
V
V
V
S
A
V
Q
N
Q
L
A
K
QPLHSQELL
D
P
L
R
A
M
L
A
K
T
L
A
A
L
T
P
-
G
-
K
L
K
Y
S
----
F
F
C
N
S
G
T
E
S
V
E
A
A
L
--
K
L
A
K
A
Y
Q
S
P
R
G
K
F
T
F
I
A
T
S
GAFHGKS
L
G
A
L
S
A
TAKS
T
F
R
---
K
P
F
M
P
L
L
P
G
F
R
H
V
PFG
N
------
I
E
A
M
----
R
T
-
A
L
N
E
C
K
K
----
T
-------
G
D
DVA
A
V
I
L
E
P
-
I
Q
G
EGGVILPPP
G
Y
L
T
A
V
R
K
L
-
C
D
-
E
F
G
A
L
M
I
L
D
E
V
-
Q
T
G
M
G
R
T
G
K
M
----
F
A
C
E
H
--
E
N
V
Q
P
D
I
L
C
L
A
K
A
L
G
G
G
V
M
P
I
G
A
T
I
A
T
E
E
V
F
S
V
L
F
D
NPF
L
H
T
T
T
F
G
GN
P
L
A
C
A
A
A
L
A
T
I
N
V
L
L
E
Q
N
L
P
A
Q
A
E
Q
K
G
D
M
-----
L
L
D
G
F
R
Q
L
-
A
R
E
Y
P
D
L
V
Q
E
A
R
G
K
G
M
L
M
A
I
--
E
-------------------------------
F
----
V
D
N
E
I
G
Y
N
F
A
S
E
M
F
R
Q
R
V
L
V
A
G
T
LNNA
K
T
I
R
IEPPLTLT
I
E
Q
C
E
----
L
V
I
K
A
A
R
K
A
L
A
A
M
R
V
S
V
E
EA
19
HHSearch
44.27
14%
-48
* C5 *
2X26
1
SSUA_ECOLI
A:
[2-161]
--------
P
E
A
L
R
I
G
Y
Q
K
G
---
S
I
G
M
V
L
A
K
S
-
H
Q
L
L
E
K
R
Y
P
E
S
----
K
I
S
W
V
E
F
P
A
-
G
P
--------------------------------------------
Q
M
L
E
A
L
N
----------
V
G
S
I
D
L
G
S
T
G
D
I
P
-
P
I
-
F
-
A
Q
A
A
G
----
A
D
-----------
L
VY
V
G
V
E
P
P
K
P
K
A
E
V
I
L
V
---------------------
A
E
N
SPI
K
T
V
A
D
L
-
K
G
H
K
V
----
A
------
F
Q
K
G
----
S
S
S
H
N
L
L
L
R
A
----
L
R
Q
A
GLKF
T
D
----
I
Q
P
---
T
Y
L
---------
T
P
A
D
A
R
A
A
F
-
Q
Q
-
G
N
V
D
A
W
A
I
--
W
-
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
43.68
18%
-62
- C5 -
3UIF
2
?
A:
[61-173]
---------------------------------------------------------------------------------------------------------
N
E
G
F
A
----------
S
G
K
I
D
F
G
I
Y
G
D
L
P
-
P
I
I
L
N
A
S
K
P
T
----
V
Q
-----------
L
--
V
A
P
W
G
T
-
T
S
N
S
Y
L
V
V
---------------------
P
K
N
STA
K
S
I
K
D
L
-
K
G
K
K
I
----
A
------
L
H
R
G
RPW
E
L
A
-
F
S
N
L
L
Q
S
E
GLT
F
-------
K
D
----
F
K
I
V
N
-
V
-----------
N
P
Q
V
G
A
A
A
L
-
A
S
-
G
T
V
D
G
F
F
S
--
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
41.34
12%
-23
- C4 -
1F6Y
-
ACSE_MOOTH
A:
[1-262]
----------
M
L
I
I
G
E
R
------
I
N
G
M
F
G
D
I
K
R
A
I
Q
E
R
D
P
A
P
V
----
Q
E
W
A
R
R
Q
E
E
G
G
A
R
A
L
D
L
N
--------------------
V
G
D
K
V
S
A
---------
M
E
W
L
V
E
V
T
Q
----------
E
V
S
------
N
L
T
L
-
C
L
-
D
-
S
T
N
I
K
----
A
I
-----------
E
--
A
G
L
K
K
C
K
N
R
---
A
M
I
---------------------
N
S
T
---
N
----------
A
----
E
------
R
E
K
V
----
E
K
-
L
F
P
L
A
V
E
----
H
-------
G
A
----
A
L
I
G
L
-
T
M
N
-----------
K
T
G
I
P
K
D
-
S
D
-
T
R
L
A
F
A
M
E
--
L
-
V
A
A
A
D
E
F
G
--------
L
P
M
--
E
D
L
Y
I
D
P
L
I
--
L
P
A
N
V
A
------
Q
D
H
A
P
E
V
L
K
T
L
Q
Q
---
I
K
M
L
A
D
------------------
P
A
-
P
K
T
V
L
G
L
S
N
V
S
-----
Q
N
C
Q
N
R
P
L
-
I
N
-
R
T
F
L
A
M
A
M
A
C
G
--
L
M
S
A
--
I
-------------------------------
A
D
A
--
C
D
E
A
L
I
E
T
A
A
T
A
E
I
L
-------------------------
L
N
Q
T
V
Y
C
D
S
F
V
K
M
F
K
T
R
-----------
38
Fugue
41.28
9%
-35
- C5 -
2X7P
11
?
A:
[14-319]
-------
L
P
T
L
K
V
A
Y
I
P
E
-------
H
F
S
T
P
L
F
F
A
Q
Q
Q
G
Y
Y
K
A
H
----
D
L
S
I
E
F
V
K
V
P
E
G
------------------------------------------
S
G
R
L
I
N
L
L
N
----------
S
N
E
V
D
I
A
I
G
L
T
E
A
-
F
I
-
A
-
D
I
A
K
G
NENI
H
V
-----------
L
--
D
T
Y
V
K
S
P
L
L
W
A
V
S
T
G
---------------------
S
N
R
---
D
D
V
T
D
A
K
Q
L
K
R
I
----
G
V
SRIGS
G
S
Y
V
M
---
S
F
-
V
L
A
H
Q
L
G
----
V
-------
P
S
----
F
D
Q
F
Q
-
V
L
S
---------
N
F
K
N
L
R
D
S
V
N
L
K
-
D
G
V
E
G
S
D
A
--
F
M
W
E
Y
F
T
S
K
K
Y
Y
D
N
--
H
E
I
K
Q
I
D
Q
I
Y
T
P
W
S
S
W
--
V
V
A
T
S
S
D
S
L
Q
A
K
S
D
V
I
K
N
F
I
D
A
V
N
Q
---
G
I
Q
Y
Y
N
E
-------
H
V
D
E
A
I
E
Y
I
S
S
N
-
L
D
Y
S
A
E
D
A
K
E
W
T
K
T
VE
F
N
S
R
I
G
K
T
-
P
L
-
D
W
D
T
I
V
V
K
T
K
D
T
L
K
L
A
G
--
V
-------------------------------
L
A
---
E
S
D
D
V
I
L
K
R
L
N
S
N
V
K
-------------------------
K
T
N
L
----
Q
L
D
G
D
L
E
-------------