@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1774: (2016-03-28 )
LDKKFLLTNSTIGIIGGGQLGRMLALAAKAMGYRIIVLDPTADCPAAQVSDEQIIADYDDKVALRELSEKADVVTYEFENIDYDALKMTQNLVSVPQGSELLSITQDRILEKAYLESANINIAPYAVIVEQDEIENEIKSIGYPAVLKTAQGGYDGKGQVVIHDARDIETAARLLRYGSCVLEAWIPFEKEISVVVARNLDGQIETFPVAENVHVNNILHTTMVPADVAADVYEEAEEIARKLAEVLQLCGVLAVEMFVTKSGAIYVNELAPRPHNSGHFTIEACSISQFTQHIRAIVGLPLVKPELLKPAVMINILGQHVDAVNKQMVNYPHWFVHYYGKKEAKINRKMGHVTVLADEPKAVIQDLEETQIWK
Atome Classification :
(30 SA)
.........10........20........30........40....---....50-.........60........70........80........90-...--...--..100.......110.......120......--.130--.......140---.......150........160.......170......--.180.......190.......200.......210.......220......-..230.--..-.....240.......250.......260.......270.......280.......290.......300...--.-.--..310......-----.-------320---.-----....---...330.......340..-.....350...-....360.......370..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LDK
K
F
L
L
TNS
T
I
G
I
IGG
G
Q
L
G
R
M
L
A
L
A
A
K
AMG
Y
R
I
I
V
LDPTADCP---AAQVS--DE
Q
I
IADYD
D
K
V
A
L
R
E
L
SEKA
D
V
V
T
Y
E
FENI
D
Y
D
A
L
K
M
T
Q
N
-
L
VS--VPQ--G
S
E
L
L
S
I
T
Q
D
R
I
L
E
K
A
Y
LESANINI
A
P
Y
A
V
I
--
V
E
Q
D
--
E
I
E
N
E
I
K
SIG---
Y
P
A
V
L
K
TA-QGGYDGK
G
Q
V
V
I
HDA
R
D
I
E
T
A
A
R
L
L
R
Y
G
--
S
C
V
L
E
A
WIPFEK
E
I
S
V
V
V
ARNLDGQ
I
E
T
F
PVAEN
V
H
VN
N
I
L
H
-TTMV
P
A
D
-
V
A
A
D
-
V
--
Y
E
-
E
A
E
E
I
A
R
K
L
A
E
V
L
Q
L
C
G
V
L
A
V
E
M
F
VTKSG
A
I
Y
V
N
E
LAPRPHNSG
H
F
T
I
E
A
C
S
I
S
Q
F
T
Q
H
I
R
A
I
VGLPLV
K
P
--
E
-L--L
K
P
A
V
M
I
N
I
L
G
-----
Q
-------
H
V
----
D
-----
A
V
N
K
---
Q
MVNYP
H
W
F
V
H
Y
YGKKE
A
-
K
INRKM
G
H
V
T
V
-LADE
P
K
A
V
I
Q
D
L
E
E
TQIWK
25
PsiBlast_CBE
99.59
52%
-114
- C2 -
3Q2O
1
?
B:
[9-378]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
--
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
--
L
P
Q
--
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
--
E
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
V
P
A
R
-
I
T
E
E
-
L
--
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
--
N
-
L
--
L
K
P
V
V
M
V
N
I
L
G
-----
E
-------
H
I
----
E
-----
G
V
L
R
---
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
-
4
PsiBlast_PDB
98.55
52%
-115
- C2 -
3QFF
1
?
A:
[9-378]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
--
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
--
L
P
Q
--
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
--
E
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
V
P
A
R
-
I
T
E
E
-
L
--
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
--
N
-
L
--
L
K
P
V
V
M
V
N
I
L
G
-----
E
-------
H
I
----
E
-----
G
V
L
R
---
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
-
1
PsiBlast_PDB
98.53
52%
-111
- C2 -
4DLK
7
?
A:
[3-372]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
--
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
--
L
P
Q
--
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
--
E
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
V
P
A
R
-
I
T
E
E
-
L
--
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
--
N
-
L
--
L
K
P
V
V
M
V
N
I
L
G
-----
E
-------
H
I
----
E
-----
G
V
L
R
---
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
-
21
PsiBlast_CBE
98.40
52%
-111
- C2 -
4DLK
4
?
B:
[3-372]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
--
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
--
L
P
Q
--
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
--
E
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
V
P
A
R
-
I
T
E
E
-
L
--
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
--
N
-
L
--
L
K
P
V
V
M
V
N
I
L
G
-----
E
-------
H
I
----
E
-----
G
V
L
R
---
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
-
24
PsiBlast_CBE
98.35
52%
-113
- C2 -
3QFF
1
?
B:
[9-378]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
--
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
--
L
P
Q
--
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
--
E
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
V
P
A
R
-
I
T
E
E
-
L
--
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
--
N
-
L
--
L
K
P
V
V
M
V
N
I
L
G
-----
E
-------
H
I
----
E
-----
G
V
L
R
---
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
-
76
HHSearch
98.26
52%
-116
- C2 -
3Q2O
1
?
A:
[8-379]
--
T
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
--
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
H
A
Y
L
--
P
-
Q
--
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
--
E
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
V
P
A
R
-
I
T
E
E
-
L
--
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
--
N
-
L
--
L
K
P
V
V
M
V
N
I
L
G
-----
E
-------
H
I
----
E
-----
G
V
L
R
---
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
D
3
PsiBlast_PDB
98.17
52%
-115
- C2 -
3Q2O
1
?
A:
[9-378]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
--
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
--
L
P
Q
--
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
--
E
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
V
P
A
R
-
I
T
E
E
-
L
--
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
--
N
-
L
--
L
K
P
V
V
M
V
N
I
L
G
-----
E
-------
H
I
----
E
-----
G
V
L
R
---
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
-
2
PsiBlast_PDB
98.15
52%
-110
- C2 -
3V4S
3
?
A:
[9-378]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
--
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
--
L
P
Q
--
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
--
E
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
V
P
A
R
-
I
T
E
E
-
L
--
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
--
N
-
L
--
L
K
P
V
V
M
V
N
I
L
G
-----
E
-------
H
I
----
E
-----
G
V
L
R
---
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
-
23
PsiBlast_CBE
97.88
52%
-113
- C2 -
3R5H
3
?
B:
[9-378]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
--
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
--
L
P
Q
--
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
--
E
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
V
P
A
R
-
I
T
E
E
-
L
--
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
--
N
-
L
--
L
K
P
V
V
M
V
N
I
L
G
-----
E
-------
H
I
----
E
-----
G
V
L
R
---
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
-
5
PsiBlast_PDB
97.78
52%
-112
- C2 -
3R5H
3
?
A:
[9-378]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
--
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
--
L
P
Q
--
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
--
E
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
V
P
A
R
-
I
T
E
E
-
L
--
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
--
N
-
L
--
L
K
P
V
V
M
V
N
I
L
G
-----
E
-------
H
I
----
E
-----
G
V
L
R
---
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
-
22
PsiBlast_CBE
97.44
52%
-111
- C2 -
3V4S
4
?
B:
[9-378]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
---
C
A
Q
V
A
--
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
--
L
P
Q
--
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
--
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
--
E
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
V
P
A
R
-
I
T
E
E
-
L
--
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
--
N
-
L
--
L
K
P
V
V
M
V
N
I
L
G
-----
E
-------
H
I
----
E
-----
G
V
L
R
---
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
-
77
HHSearch
89.59
44%
-99
- C2 -
3ORQ
3
?
A:
[5-374]
-
N
F
N
K
L
K
F
G
A
T
I
G
I
I
G
G
G
Q
L
G
K
M
M
A
Q
S
A
Q
K
M
G
Y
K
V
V
V
L
D
P
S
E
D
C
P
---
C
R
Y
V
A
--
H
E
F
I
Q
A
K
Y
D
D
E
K
A
L
N
Q
L
G
Q
K
C
D
V
I
T
Y
E
F
E
N
I
S
A
Q
Q
L
K
L
L
C
E
K
Y
N
I
--
P
-
Q
--
G
Y
Q
A
I
Q
L
L
Q
D
R
L
T
E
K
E
T
L
K
S
A
G
T
K
V
V
P
F
I
S
V
--
K
E
S
T
--
D
I
D
K
A
I
E
T
L
G
---
Y
P
F
I
V
K
T
R
-
F
G
G
Y
D
G
K
G
Q
V
L
I
N
N
E
K
D
L
Q
E
G
F
K
L
I
E
T
S
--
E
C
V
A
E
K
Y
L
N
I
K
K
E
V
S
L
T
V
T
R
G
N
N
N
Q
I
T
F
F
P
L
Q
E
N
E
H
R
N
Q
I
L
F
-
K
T
I
V
P
A
R
-
I
D
K
-----
T
A
-
E
A
K
E
Q
V
N
K
I
I
Q
S
I
H
F
I
G
T
F
T
V
E
F
F
I
D
S
N
N
Q
L
Y
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
S
I
E
A
C
D
Y
S
Q
F
D
T
H
I
L
A
V
T
G
Q
S
L
P
N
S
--
I
E
L
--
L
K
P
A
V
M
M
N
L
L
G
-----
K
-------
D
L
----
D
-----
L
L
E
N
---
E
F
N
E
H
P
E
W
H
L
H
I
Y
G
K
S
E
R
-
K
D
S
R
K
M
G
H
M
T
V
-
L
T
N
D
V
N
Q
T
E
Q
D
M
Y
A
K
F
E
--
8
PsiBlast_PDB
86.24
41%
-99
- C2 -
4E4T
3
?
A:
[32-398]
-----
I
L
P
G
A
W
L
G
M
V
G
G
G
Q
L
G
R
M
F
C
F
A
A
Q
S
M
G
Y
R
V
A
V
L
D
P
D
P
A
S
P
---
A
G
A
V
A
--
D
R
H
L
R
A
A
Y
D
D
E
A
A
L
A
E
L
A
G
L
C
E
A
V
S
T
E
F
E
N
V
P
A
A
S
L
D
F
L
A
R
-
T
T
F
--
V
A
P
--
A
G
R
C
V
A
V
A
Q
D
R
I
A
E
K
R
F
I
E
A
S
G
V
P
V
A
P
H
V
V
I
--
E
S
A
A
--
A
L
A
A
L
D
D
A
A
L
D
A
V
L
P
G
I
L
K
T
A
-
R
L
G
Y
D
G
K
G
Q
V
R
V
S
T
A
R
E
A
R
D
A
H
A
A
L
G
G
V
--
P
C
V
L
E
K
R
L
P
L
K
Y
E
V
S
A
L
I
A
R
G
A
D
G
R
S
A
A
F
P
L
A
Q
N
V
H
H
N
G
I
L
A
-
L
T
I
V
P
A
P
--
A
A
D
-
T
A
R
V
E
-
E
A
Q
Q
A
A
V
R
I
A
D
T
L
G
Y
V
G
V
L
C
V
E
F
F
V
L
E
D
G
S
F
V
A
N
E
M
A
P
R
P
H
N
S
G
H
Y
T
V
D
A
C
A
T
S
Q
F
E
Q
Q
V
R
A
M
T
R
M
P
L
G
N
P
--
R
-
Q
--
H
S
P
A
A
M
L
N
I
L
G
-----
D
VWFPNGA
A
A
----
G
-----
A
V
T
P
P
W
D
T
V
A
A
M
P
A
A
H
L
H
L
Y
G
K
E
E
A
-
R
V
G
R
K
M
G
H
V
N
F
-
T
A
E
----------------
6
PsiBlast_PDB
85.05
43%
-101
- C2 -
3ORQ
3
?
A:
[20-368]
----------------
G
G
Q
L
G
K
M
M
A
Q
S
A
Q
K
M
G
Y
K
V
V
V
L
D
P
S
E
D
C
P
---
C
R
Y
V
A
--
H
E
F
I
Q
A
K
Y
D
D
E
K
A
L
N
Q
L
G
Q
K
C
D
V
I
T
Y
E
F
E
N
I
S
A
Q
Q
L
K
L
L
C
E
-
K
Y
N
--
I
P
Q
--
G
Y
Q
A
I
Q
L
L
Q
D
R
L
T
E
K
E
T
L
K
S
A
G
T
K
V
V
P
F
I
S
V
--
K
E
S
T
--
D
I
D
K
A
I
E
T
L
G
---
Y
P
F
I
V
K
T
R
-
F
G
G
Y
D
G
K
G
Q
V
L
I
N
N
E
K
D
L
Q
E
G
F
K
L
I
E
T
S
--
E
C
V
A
E
K
Y
L
N
I
K
K
E
V
S
L
T
V
T
R
G
N
N
N
Q
I
T
F
F
P
L
Q
E
N
E
H
R
N
Q
I
L
F
-
K
T
I
V
P
A
R
-
I
--
D
-
K
--
T
A
-
E
A
K
E
Q
V
N
K
I
I
Q
S
I
H
F
I
G
T
F
T
V
E
F
F
I
D
S
N
N
Q
L
Y
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
S
I
E
A
C
D
Y
S
Q
F
D
T
H
I
L
A
V
T
G
Q
S
L
P
N
S
I-
E
-
L
--
L
K
P
A
V
M
M
N
L
L
G
-----
K
-------
D
L
----
D
-----
L
L
E
N
---
E
F
N
E
H
P
E
W
H
L
H
I
Y
G
K
S
E
R
-
K
D
S
R
K
M
G
H
M
T
V
-
L
T
N
D
V
N
Q
T
E
Q
D
--------
26
PsiBlast_CBE
85.01
41%
-102
- C2 -
4E4T
2
?
B:
[32-398]
-----
I
L
P
G
A
W
L
G
M
V
G
G
G
Q
L
G
R
M
F
C
F
A
A
Q
S
M
G
Y
R
V
A
V
L
D
P
D
P
A
S
P
---
A
G
A
V
A
--
D
R
H
L
R
A
A
Y
D
D
E
A
A
L
A
E
L
A
G
L
C
E
A
V
S
T
E
F
E
N
V
P
A
A
S
L
D
F
L
A
R
-
T
T
F
--
V
A
P
--
A
G
R
C
V
A
V
A
Q
D
R
I
A
E
K
R
F
I
E
A
S
G
V
P
V
A
P
H
V
V
I
--
E
S
A
A
--
A
L
A
A
L
D
D
A
A
L
D
A
V
L
P
G
I
L
K
T
A
-
R
-----
K
G
Q
V
R
V
S
T
A
R
E
A
R
D
A
H
A
A
L
G
G
V
--
P
C
V
L
E
K
R
L
P
L
K
Y
E
V
S
A
L
I
A
R
G
A
D
G
R
S
A
A
F
P
L
A
Q
N
V
H
H
N
G
I
L
A
-
L
T
I
V
P
A
P
--
A
A
D
-
T
A
R
V
E
-
E
A
Q
Q
A
A
V
R
I
A
D
T
L
G
Y
V
G
V
L
C
V
E
F
F
V
L
E
D
G
S
F
V
A
N
E
M
A
P
R
P
H
N
S
G
H
Y
T
V
D
A
C
A
T
S
Q
F
E
Q
Q
V
R
A
M
T
R
M
P
L
G
N
P
--
R
-
Q
--
H
S
P
A
A
M
L
N
I
L
G
-----
D
VWFPNGA
A
A
----
G
-----
A
V
T
P
P
W
D
T
V
A
A
M
P
A
A
H
L
H
L
Y
G
K
E
E
A
-
R
V
G
R
K
M
G
H
V
N
F
-
T
A
E
----------------
81
HHSearch
84.61
42%
-102
- C2 -
3AX6
1
?
A:
[1-367]
--------
M
K
K
I
G
I
I
G
G
G
Q
L
G
K
M
M
T
L
E
A
K
K
M
G
F
Y
V
I
V
L
D
P
T
P
R
S
P
---
A
G
Q
V
A
--
D
E
Q
I
V
A
G
F
F
D
S
E
R
I
E
D
L
V
K
G
S
D
V
T
T
Y
D
L
E
H
I
D
V
Q
T
L
K
K
L
Y
N
-
E
G
Y
K-
I
H
P
--
S
P
Y
T
L
E
I
I
Q
D
K
F
V
Q
K
E
F
L
K
K
N
G
I
P
V
P
E
Y
K
L
V
--
K
D
L
E
--
S
---
D
V
R
E
F
G
---
F
P
V
V
Q
K
A
R
-
K
G
-----
G
V
F
I
I
K
N
E
K
D
L
E
N
A
I
K
----
G
--
E
T
Y
L
E
E
F
V
E
I
E
K
E
L
A
V
M
V
A
R
N
E
K
G
E
I
A
C
Y
P
V
V
E
M
Y
------
D
-
T
V
I
A
P
A
R
-
I
E
E
K
-
Y
--
S
K
-
I
A
R
E
I
A
T
S
V
V
E
A
L
E
G
V
G
I
F
G
I
E
M
F
L
T
K
Q
G
E
I
L
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
T
I
E
A
C
V
T
S
Q
F
E
Q
H
I
R
A
I
M
N
L
P
L
G
S
T
--
E
-
L
--
L
I
P
A
V
M
V
N
L
L
G
-----
E
-------
E
G
Y---
Y
G
K
P
A
L
I
G
L
E
---
E
A
L
A
I
E
G
L
S
L
H
F
Y
G
K
K
E
T
-
R
P
Y
R
K
M
G
H
F
T
V
-
V
D
R
D
V
E
R
A
L
E
K
A
L
R
A
K
K
I
-
78
HHSearch
81.58
35%
-104
* C2 *
3AW8
2
?
A:
[1-360]
----------
M
I
G
I
L
G
G
G
Q
L
G
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
R
F
L
D
P
S
P
E
A
C
---
A
G
Q
V
G
--
E
-
L
V
V
G
E
F
L
D
E
G
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
A
R
R
L
E
G
R
L
P
L
---
Y
P
--
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
--
D
G
P
E
--
D
L
E
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
------
G
Q
A
L
V
R
T
E
E
E
A
L
E
A
L
K
A
L
G
G
R
--
G
L
I
L
E
G
F
V
P
F
D
R
E
V
S
L
L
A
V
R
G
R
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
-
L
S
L
A
P
A
P
G
A
S
E
A
-
L
--
Q
K
-
K
A
E
A
Y
A
L
R
A
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
Q
V
G
-
E
E
L
L
F
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
G
S
T
--
A
-
P
--
R
G
Q
S
A
M
V
N
L
I
G
-----
E
-------
K
P
-----------
P
F
A
---
E
V
L
K
V
E
G
A
H
L
H
W
Y
G
K
A
-
V
-
R
P
G
R
K
V
G
H
I
T
L
-
R
R
D
G
L
K
A
L
E
E
G
L
A
R
L
S
R
L
V
79
HHSearch
80.64
32%
-93
- C2 -
3K5I
5
?
A:
[21-398]
-----
M
W
N
S
R
K
V
G
V
L
G
G
G
Q
L
G
R
M
L
V
E
S
A
N
R
L
N
I
Q
V
N
V
L
D
A
D
N
-
S
P
---
A
K
Q
I
S
AH
D
G
H
V
T
G
S
F
K
E
R
E
A
V
R
Q
L
A
K
T
C
D
V
V
T
A
E
I
E
H
V
D
T
Y
A
L
E
E
V
A
S
E
V
K
I
---
E
P
--
S
W
Q
A
I
R
T
I
Q
N
K
F
N
Q
K
E
H
L
R
K
Y
G
I
P
M
A
E
H
R
E
L
VE
N
T
P
A
--
E
L
A
K
V
G
E
Q
L
G
---
Y
P
L
M
L
K
S
K
-
T
M
A
Y
D
G
R
G
N
F
R
V
N
S
Q
D
D
I
P
E
A
L
E
A
L
K
D
R
--
P
L
Y
A
E
K
W
A
Y
F
K
M
E
L
A
V
I
V
V
K
T
-
K
D
E
V
L
S
Y
P
T
V
E
T
V
Q
E
D
S
I
C
K
-
L
V
Y
A
P
A
R
N
V
S
D
A
-
I
--
N
Q
-
K
A
Q
E
L
A
R
K
A
V
A
A
F
D
G
K
G
V
F
G
V
E
M
F
L
L
E
D
D
S
I
M
L
C
E
I
A
S
R
I
H
N
S
G
H
Y
T
I
E
G
C
A
L
S
Q
F
D
A
H
L
R
A
I
L
D
L
P
I
P
A
Q
--
S
-
L
EI
R
Q
P
S
I
M
L
N
I
I
G
-----
G
-------
A
A
PD
T
H
L
-----
Q
A
A
E
---
C
A
L
S
I
P
N
A
S
I
H
L
Y
-
S
K
G
A
A
K
P
G
R
K
M
G
H
I
T
V
-
T
A
P
T
M
H
E
A
E
T
H
I
Q
P
L
I
D
V
V
32
PsiBlast_CBE
79.19
33%
-102
- C2 -
3K5H
3
?
B:
[37-381]
---------------------
R
M
L
V
E
S
A
N
R
L
N
I
Q
V
N
V
L
D
-
A
D
N
S
P
---
A
K
Q
I
S
AH
D
G
H
V
T
G
S
F
K
E
R
E
A
V
R
Q
L
A
K
T
C
D
V
V
T
A
E
I
E
H
V
D
T
Y
A
L
E
E
V
A
S
-
E
V
K
--
I
E
P
--
S
W
Q
A
I
R
T
I
Q
N
K
F
N
Q
K
E
H
L
R
K
Y
G
I
P
M
A
E
H
R
E
L
--
V
E
N
T
P
A
E
L
A
K
V
G
E
Q
L
G
---
Y
P
L
M
L
K
S
K
-
T
M
A
Y
D
G
R
G
N
F
R
V
N
S
Q
D
D
I
P
E
A
L
E
A
L
K
D
R
--
P
L
Y
A
E
K
W
A
Y
F
K
M
E
L
A
V
I
V
V
K
T
K
D
-
E
V
L
S
Y
P
T
V
E
T
V
Q
E
D
S
I
C
K
-
L
V
Y
A
P
A
R
-
N
V
S
D
A
I
--
N
Q
-
K
A
Q
E
L
A
R
K
A
V
A
A
F
D
G
K
G
V
F
G
V
E
M
F
L
L
E
D
D
S
I
M
L
C
E
I
A
S
R
I
H
N
S
G
H
Y
T
I
E
G
C
A
L
S
Q
F
D
A
H
L
R
A
I
L
D
L
P
I
P
A
Q
SL
E
-
I
--
R
Q
P
S
I
M
L
N
I
I
G
G
AAPD
T
-------
H
L
----
Q
-----
A
A
-
E
---
C
A
L
S
I
P
N
A
S
I
H
L
Y
S
K
G
A
A
-
K
P
G
R
K
M
G
H
I
T
V
-
T
A
-----------------
30
PsiBlast_CBE
79.09
33%
-103
- C2 -
3K5H
3
?
D:
[37-381]
---------------------
R
M
L
V
E
S
A
N
R
L
N
I
Q
V
N
V
L
D
-
A
D
N
S
P
---
A
K
Q
I
S
AH
D
G
H
V
T
G
S
F
K
E
R
E
A
V
R
Q
L
A
K
T
C
D
V
V
T
A
E
I
E
H
V
D
T
Y
A
L
E
E
V
A
S
-
E
V
K
--
I
E
P
--
S
W
Q
A
I
R
T
I
Q
N
K
F
N
Q
K
E
H
L
R
K
Y
G
I
P
M
A
E
H
R
E
L
--
V
E
N
T
PA
E
L
A
K
V
G
E
Q
L
G
---
Y
P
L
M
L
K
S
K
-
T
M
A
Y
D
G
R
G
N
F
R
V
N
S
Q
D
D
I
P
E
A
L
E
A
L
K
D
R
--
P
L
Y
A
E
K
W
A
Y
F
K
M
E
L
A
V
I
V
V
K
T
K
D
-
E
V
L
S
Y
P
T
V
E
T
V
Q
E
D
S
I
C
K
-
L
V
Y
A
P
A
R
-
N
V
S
D
A
I
--
N
Q
-
K
A
Q
E
L
A
R
K
A
V
A
A
F
D
G
K
G
V
F
G
V
E
M
F
L
L
E
D
D
S
I
M
L
C
E
I
A
S
R
I
H
N
S
G
H
Y
T
I
E
G
C
A
L
S
Q
F
D
A
H
L
R
A
I
L
D
L
P
I
P
A
Q
SL
E
-
I
--
R
Q
P
S
I
M
L
N
I
I
G
GAAPD
T
-------
H
L
----
Q
-----
A
A
-
E
---
C
A
L
S
I
P
N
A
S
I
H
L
Y
S
K
G
A
A
-
K
P
G
R
K
M
G
H
I
T
V
-
T
A
-----------------
15
PsiBlast_PDB
78.77
34%
-98
- C2 -
4MAM
3
?
A:
[3-346]
-----------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
N
G
D
C
A
EEV
V
K
T
V
T
--
D
I
E
L
-
T
K
V
N
D
V
V
A
W
---
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
A
I
N
H
-
E
V
S
--
V
Y
P
--
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
--
D
S
L
A
--
K
L
Q
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
K
D
A
PD
G
L
I
Y
E
A
F
V
D
F
D
Y
E
V
S
Q
I
C
T
A
D
L
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
-
E
S
E
A
P
F
E
-
N
V
V
--
L
--
A
E
-
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
-
K
G
D
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
-
I
L
G
D
--
T
-
T
--
S
R
K
T
V
M
L
N
C
I
G
-----
G
-------
M
-----------
P
A
T
K
---
D
L
A
A
L
D
R
V
K
I
H
S
Y
-
N
K
E
P
-
R
K
G
R
K
V
G
H
L
N
L
N
L
N
D
E
---------------
13
PsiBlast_PDB
78.08
34%
-99
- C2 -
4MA0
4
?
A:
[3-346]
-----------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
N
G
D
C
A
EEV
V
K
T
V
T
--
D
I
E
L
-
T
K
V
N
D
V
V
A
W
---
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
A
I
N
H
-
E
V
S
--
V
Y
P
--
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
--
D
S
L
A
--
K
L
Q
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
K
D
A
PD
G
L
I
Y
E
A
F
V
D
F
D
Y
E
V
S
Q
I
C
T
A
D
L
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
-
E
S
E
A
P
F
E
-
N
V
V
--
L
--
A
E
-
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
-
K
G
D
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
-
I
L
G
D
--
T
-
T
--
S
R
K
T
V
M
L
N
C
I
G
-----
G
-------
M
-----------
P
A
T
K
---
D
L
A
A
L
D
R
V
K
I
H
S
Y
-
N
K
E
P
-
R
K
G
R
K
V
G
H
L
N
L
N
L
N
D
E
---------------
14
PsiBlast_PDB
77.12
34%
-99
- C2 -
4MA5
5
?
A:
[3-346]
-----------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
N
G
D
C
A
EEV
V
K
T
V
T
--
D
I
E
L
-
T
K
V
N
D
V
V
A
W
---
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
A
I
N
H
-
E
V
S
--
V
Y
P
--
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
--
D
S
L
A
--
K
L
Q
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
K
D
A
PD
G
L
I
Y
E
A
F
V
D
F
D
Y
E
V
S
Q
I
C
T
A
D
L
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
-
E
S
E
A
P
F
E
-
N
V
V
--
L
--
A
E
-
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
-
K
--
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
-
I
L
G
D
--
T
-
T
--
S
R
K
T
V
M
L
N
C
I
G
-----
G
-------
M
-----------
P
A
T
K
---
D
L
A
A
L
D
R
V
K
I
H
S
Y
-
N
K
E
P
-
R
K
G
R
K
V
G
H
L
N
L
N
L
N
D
E
---------------
27
PsiBlast_CBE
76.97
34%
-94
- C2 -
3AW8
3
?
B:
[12-353]
---------------------
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
R
F
L
D
P
S
P
E
A
C
---
A
G
Q
V
G
---
E
L
V
V
G
E
F
L
D
E
G
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
A
R
R
L
E
G
-
R
L
P
--
L
Y
P
--
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
--
D
G
P
E
--
D
L
E
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
G
------
Q
A
L
V
R
T
E
E
E
A
L
E
A
L
K
A
L
G
G
R
--
G
L
I
L
E
G
F
V
P
F
D
R
E
V
S
L
L
A
V
R
G
R
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
-
L
S
L
A
P
A
P
-
G
A
S
E
-
A
--
L
Q
K
K
A
E
A
Y
A
L
R
A
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
Q
V
G
E
E
L
L
F
-
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
G
S
T
--
A
-
P
--
R
G
Q
S
A
M
V
N
L
I
G
-----
E
-------
K
P
----
P
-----
F
A
E
V
---
L
K
V
E
G
A
H
--
L
H
W
Y
G
K
A
-
V
-
R
P
G
R
K
V
G
H
I
T
L
-
R
R
D
G
L
K
A
L
E
E
G
L
-------
10
PsiBlast_PDB
76.26
34%
-96
- C2 -
3AW8
2
?
A:
[12-353]
---------------------
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
R
F
L
D
P
S
P
E
A
C
---
A
G
Q
V
G
---
E
L
V
V
G
E
F
L
D
E
G
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
A
R
R
L
E
G
-
R
L
P
--
L
Y
P
--
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
--
D
G
P
E
--
D
L
E
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
G
------
Q
A
L
V
R
T
E
E
E
A
L
E
A
L
K
A
L
G
G
R
--
G
L
I
L
E
G
F
V
P
F
D
R
E
V
S
L
L
A
V
R
G
R
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
-
L
S
L
A
P
A
P
-
G
A
S
E
-
A
--
L
Q
K
K
A
E
A
Y
A
L
R
A
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
Q
V
G
E
E
L
L
F
-
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
G
S
T
--
A
-
P
--
R
G
Q
S
A
M
V
N
L
I
G
-----
E
-------
K
P
----
P
-----
F
A
E
V
---
L
K
V
E
G
A
H
--
L
H
W
Y
G
K
A
-
V
-
R
P
G
R
K
V
G
H
I
T
L
-
R
R
D
G
L
K
A
L
E
E
G
L
-------
34
PsiBlast_CBE
75.72
33%
-103
- C2 -
3ETH
3
PURK_ECOLI
B:
[4-333]
-----------
V
C
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
--
I
A
V
W
P
V
G
L
D
A
E
---
P
A
A
V
P
--
F
Q
Q
------------------
S
V
I
T
A
E
I
E
R
W
P
E
T
A
L
--
T
R
Q
-
L
A
R
--
H
P
A
FV
N
R
D
V
F
P
I
I
A
D
R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
--
A
E
R
S
--
E
W
P
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
-
T
G
G
Y
D
G
R
G
Q
W
R
L
R
A
N
E
T
E
Q
L
P
A
E
C
--
Y
G
--
E
C
I
V
E
Q
G
I
N
F
S
G
E
V
S
L
V
G
A
R
G
F
D
G
S
T
V
F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
-
T
S
V
A
F
P
Q
-
A
N
A
Q
-
Q
--
Q
A
-
R
A
E
E
M
L
S
A
I
M
Q
E
L
G
Y
V
G
V
M
A
M
E
C
F
V
T
P
Q
G
-
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
D
L
P
L
P
Q
P
--
V
-
V
--
N
N
P
S
V
M
I
N
L
I
G
-----
S
-------
D
------------
V
N
Y
---
D
W
L
K
L
P
L
V
H
L
H
W
Y
-
D
K
E
V
-
R
P
G
R
K
V
G
H
L
N
L
-
T
D
S
D
T
S
R
L
T
A
T
L
E
------
20
PsiBlast_PDB
75.66
33%
-101
- C2 -
3ETJ
5
PURK_ECOLI
A:
[4-333]
-----------
V
C
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
--
I
A
V
W
P
V
G
L
D
A
E
---
P
A
A
V
P
--
F
Q
Q
------------------
S
V
I
T
A
E
I
E
R
W
P
E
T
A
L
--
T
R
Q
-
L
A
R
--
H
P
A
FV
N
R
D
V
F
P
I
I
A
D
R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
--
A
E
R
S
--
E
W
P
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
-
T
G
G
Y
D
G
R
G
Q
W
R
L
R
A
N
E
T
E
Q
L
P
A
E
C
--
Y
G
--
E
C
I
V
E
Q
G
I
N
F
S
G
E
V
S
L
V
G
A
R
G
F
D
G
S
T
V
F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
-
T
S
V
A
F
P
Q
-
A
N
A
Q
-
Q
--
Q
A
-
R
A
E
E
M
L
S
A
I
M
Q
E
L
G
Y
V
G
V
M
A
M
E
C
F
V
T
P
Q
G
-
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
D
L
P
L
P
Q
P
--
V
-
V
--
N
N
P
S
V
M
I
N
L
I
G
-----
S
-------
D
------------
V
N
Y
---
D
W
L
K
L
P
L
V
H
L
H
W
Y
-
D
K
E
V
-
R
P
G
R
K
V
G
H
L
N
L
-
T
D
S
D
T
S
R
L
T
A
T
L
E
------
19
PsiBlast_PDB
75.41
33%
-102
- C2 -
3ETH
3
PURK_ECOLI
A:
[4-333]
-----------
V
C
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
--
I
A
V
W
P
V
G
L
D
A
E
---
P
A
A
V
P
--
F
Q
Q
------------------
S
V
I
T
A
E
I
E
R
W
P
E
T
A
L
--
T
R
Q
-
L
A
R
--
H
P
A
FV
N
R
D
V
F
P
I
I
A
D
R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
--
A
E
R
S
--
E
W
P
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
-
T
G
G
Y
D
G
R
G
Q
W
R
L
R
A
N
E
T
E
Q
L
P
A
E
C
--
Y
G
--
E
C
I
V
E
Q
G
I
N
F
S
G
E
V
S
L
V
G
A
R
G
F
D
G
S
T
V
F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
-
T
S
V
A
F
P
Q
-
A
N
A
Q
-
Q
--
Q
A
-
R
A
E
E
M
L
S
A
I
M
Q
E
L
G
Y
V
G
V
M
A
M
E
C
F
V
T
P
Q
G
-
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
D
L
P
L
P
Q
P
--
V
-
V
--
N
N
P
S
V
M
I
N
L
I
G
-----
S
-------
D
------------
V
N
Y
---
D
W
L
K
L
P
L
V
H
L
H
W
Y
-
D
K
E
V
-
R
P
G
R
K
V
G
H
L
N
L
-
T
D
S
D
T
S
R
L
T
A
T
L
E
------
84
HHSearch
74.53
33%
-98
- C2 -
3ETH
3
PURK_ECOLI
A:
[1-339]
--------
M
K
Q
V
C
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
I
A
V
W
P
V
G
L
D
A
E
P
----
A
A
V
P
---------------------
F
Q
Q
S
V
I
T
A
E
I
E
R
W
P
---
E
T
A
L
T
R
Q
L
A
R
HP
A
F
V
--
N
R
D
V
F
P
I
I
A
D
R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
--
A
E
R
S
--
E
W
P
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
T
G
G
-
Y
D
G
R
G
Q
W
R
L
R
A
N
E
T
E
Q
-
L
P
A
E
-
C
Y
G
--
E
C
I
V
E
Q
G
I
N
F
S
G
E
V
S
L
V
G
A
R
G
F
D
G
S
T
V
F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
T
S
V
A
F
P
Q
--
A
N
A
Q
-
Q
--
Q
A
-
R
A
E
E
M
L
S
A
I
M
Q
E
L
G
Y
V
G
V
M
A
M
E
C
F
V
T
P
-
Q
G
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
D
L
P
L
P
Q
P
--
V
-
V
--
N
N
P
S
V
M
I
N
L
I
G
-----
S
-------
D
V
-----------
N
Y
----
D
W
L
K
L
P
L
V
H
L
H
W
Y
D
K
-
E
V
-
R
P
G
R
K
V
G
H
L
N
L
-
T
D
S
D
T
S
R
L
T
A
T
L
E
A
L
I
P
L
L
33
PsiBlast_CBE
73.99
33%
-103
- C2 -
3ETJ
4
PURK_ECOLI
B:
[4-333]
-----------
V
C
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
--
I
A
V
W
P
V
G
L
D
A
E
---
P
A
A
V
P
--
F
Q
Q
------------------
S
V
I
T
A
E
I
E
R
W
P
E
T
A
L
--
T
R
Q
-
L
A
R
--
H
P
A
FV
N
R
D
V
F
P
I
I
A
D
R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
--
A
E
R
S
--
E
W
P
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
-
T
G
G
----
G
Q
W
R
L
R
A
N
E
T
E
Q
L
P
A
E
C
--
Y
G
--
E
C
I
V
E
Q
G
I
N
F
S
G
E
V
S
L
V
G
A
R
G
F
D
G
S
T
V
F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
-
T
S
V
A
F
P
Q
-
A
N
A
Q
-
Q
--
Q
A
-
R
A
E
E
M
L
S
A
I
M
Q
E
L
G
Y
V
G
V
M
A
M
E
C
F
V
T
P
Q
G
-
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
D
L
P
L
P
Q
P
--
V
-
V
--
N
N
P
S
V
M
I
N
L
I
G
-----
S
-------
D
------------
V
N
Y
---
D
W
L
K
L
P
L
V
H
L
H
W
Y
-
D
K
E
V
-
R
P
G
R
K
V
G
H
L
N
L
-
T
D
S
D
T
S
R
L
T
A
T
L
E
------