@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2537: (2016-04-04 )
LAKIKVMSIFGTRPEAIKMAPLVLALEKEPETFESTVVITAQHREMLDQVLEIFDIKPDIDLDIMKKGQTLAEITSRVMNGINEVIAAENPDIVLVHGDTTTSFAAGLATFYQQKMLGHVEAGLRTWNKYSPFPEEMNRQLTGVMADIHFSPTKQAKENLLAEGKDPATIFVTGNTAIDALKTTVQKDYHHPILENLGDNRLILMTAHRRENLGEPMQGMFEAVREIVESREDTELVYPMHLNPAVREKAMAILGGHERIHLIEPLDAIDFHNFLRKSYLVFTDSGGVQEEAPGMGVPVLVLRDTTERPEGIEAGTLKLIGTNKENLIKEALDLLDNKESHDKMAQAANPYGDGFAANRILAAIKSHFEETDRPEDFIV
Atome Classification :
(20 SA)
-------------------------------.........10...---.-----....20........30....-....-.40..-...--...50--....---....60......----..70........80.....--...90........100.......110.......120.---......130.----.......140.......150-.......160.-......170...-.-...180--.-----------.....----.-----------..190..-----..-..--.200.......210.--.-.....220.......230--.......240..------.-.----.-..250---.---......260.---..---....270....---...280...-----....290.......300.-.......310...-....320-.......330.......340.......350..-.-.....360......-.370.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------LA
K
I
K
V
M
S
IFGTRP---E-----
A
I
K
MA
P
L
V
L
A
LEKEP-ETFE-
S
T
V
V
-
I
T
A
Q
H
-
R
E
M
--
L
D
Q
V
L
--
E
I
FD---IKPDI
D
L
D
I
M
KK----G
Q
T
L
A
E
I
T
S
R
V
M
N
G
I
N
E
V
I--AAENP
D
I
V
L
V
HGDT
T
T
S
F
A
A
G
L
A
T
F
Y
Q
Q
K
M
L
G
H
V
E
A
G
---
L
R
TWNKY-SP----
F
P
E
E
M
N
R
Q
L
T
G
V
M
A
DIHFS
P
-
T
K
Q
A
K
E
N
L
LAE-GKD
P
A
T
I
F
V
TGN-
T
-
A
I
D
A
----
L
-----------
K
T
T
V
Q
----K-----------DYH
H
P
I
L
-----
E
N-LG--D
N
R
L
I
L
M
TA
H
R
R
ENL--G-
E
P
M
Q
G
M
F
E
A
V
R
E
I
V
ESRE--DT
E
L
V
Y
P
MHL
N
P
------
A
-
V
----
R
-
E
K
A
M
A
---
I
---LGGH
E
R
I
H
L
I---EP---
L
D
A
I
D
F
H
N
F
L
R
---K
S
Y
L
V
F
TDS-----GGVQEEAPGMG
V
P
V
L
V
-L-RDTTERPEGIEAG-
T
L
K
L
I
GT-
N
K
E
N
L
I
K
E
A
L
D
LLDNK
E
S
H
D
K
M
A
Q
AANP-YGD-
G
-
F
A
A
N
R
I
L
A
A
I
K
S
H
F
-EETDRPEDFIV
1
PsiBlast_PDB
99.95
99%
-98
- C2 -
3OT5
2
?
A:
[26-403]
--------------------------------
A
K
I
K
V
M
S
I
F
G
T
R
P
---
E
-----
A
I
K
M
A
P
L
V
L
A
L
E
K
E
P
-
E
T
F
E
-
S
T
V
V
-
I
T
A
--------
L
D
Q
V
L
--
E
I
F
D
---
I
K
P
D
I
D
L
D
I
M
K
-----
G
Q
T
L
A
E
I
T
S
R
V
M
N
G
I
N
E
V
I
--
A
A
E
N
P
D
I
V
L
V
H
G
D
T
T
T
S
F
A
A
G
L
A
T
F
Y
Q
Q
K
M
L
G
H
V
E
A
G
---
L
R
T
W
N
K
Y
-
S
P
----
F
P
E
E
M
N
R
Q
L
T
G
V
M
A
D
I
H
F
S
P
-
T
K
Q
A
K
E
N
L
L
A
E
-
G
K
D
P
A
T
I
F
V
T
G
N
-
T
-
A
I
D
A
----
L
-----------
K
T
T
V
Q
----
K
-----------
D
Y
H
H
P
I
L
-----
E
N
-
L
G
--
D
N
R
L
I
L
M
T
A
H
R
R
E
N
L
--
G
-
E
P
M
Q
G
M
F
E
A
V
R
E
I
V
E
S
R
E
--
D
T
E
L
V
Y
P
M
H
L
N
P
------
A
-
V
----
R
-
E
K
A
M
A
---
I
---
L
G
G
H
E
R
I
H
L
I
---
E
P
---
L
D
A
I
D
F
H
N
F
L
R
---
K
S
Y
L
V
F
T
D
S
-----
G
G
V
Q
E
E
A
P
G
M
G
V
P
V
L
V
-
L
-
R
D
T
T
E
R
P
E
G
I
E
A
G
-
T
L
K
L
I
G
T
-
N
K
E
N
L
I
K
E
A
L
D
L
L
D
N
K
E
S
H
D
K
M
A
Q
A
A
N
P
-
Y
G
D
-
G
-
F
A
A
N
R
I
L
A
A
I
K
S
H
F
-
E
E
T
D
R
P
E
D
F
I
V
23
HHSearch
95.28
94%
-95
- C2 -
3OT5
2
?
A:
[26-402]
--------------------------------
A
K
I
K
V
M
S
I
F
G
T
R
P
---
E
-----
A
I
K
M
A
P
L
V
L
A
L
E
K
E
P
E
T
-
F
E
-
S
T
V
V
-
I
T
A
--------
L
D
Q
V
L
--
E
I
F
D
---
I
K
P
D
I
D
L
D
I
M
K
-----
G
Q
T
L
A
E
I
T
S
R
V
M
N
G
I
N
E
V
I
--
A
A
E
N
P
D
I
V
L
V
H
G
D
T
T
T
S
F
A
A
G
L
A
T
F
Y
Q
Q
K
M
L
G
H
V
E
A
G
---
L
R
T
W
N
K
Y
-
S
P
----
F
P
E
E
M
N
R
Q
L
T
G
V
M
A
D
I
H
F
S
P
-
T
K
Q
A
K
E
N
L
L
A
E
-
G
K
D
P
A
T
I
F
V
T
G
N
-
T
A
I
D
A
L
----
K
-----------
T
T
V
Q
K
----
D
-----------
Y
H
-
H
P
I
L
-----
E
N
-
L
G
--
D
N
R
L
I
L
M
T
A
H
R
R
E
N
L
--
G
-
E
P
M
Q
G
M
F
E
A
V
R
E
I
V
E
S
R
E
--
D
T
E
L
V
-
Y
P
M
H
L
N
------
P
-
A
----
V
R
E
K
A
M
A
---
I
---
L
G
G
H
E
R
I
H
L
I
---
E
P
---
L
D
A
I
D
F
H
N
F
L
R
---
K
S
Y
L
V
F
T
D
S
-----
G
G
V
Q
E
E
A
P
G
M
G
V
P
V
L
V
-
L
-
R
D
T
T
E
R
P
E
G
I
E
A
G
-
T
L
K
L
I
G
T
-
N
K
E
N
L
I
K
E
A
L
D
L
L
D
N
K
E
S
H
D
K
M
A
Q
A
A
N
P
-
Y
G
D
-
G
-
F
A
A
N
R
I
L
A
A
I
K
S
H
F
-
E
E
T
D
R
P
E
D
F
I
-
20
PsiBlast_CBE
87.47
67%
-86
- C2 -
3BEO
2
?
B:
[8-375]
---------------------------------
R
L
K
V
M
T
I
F
G
T
R
P
---
E
-----
A
I
K
M
A
P
L
V
L
E
L
Q
K
H
P
-
E
K
I
E
-
S
I
V
T
-
V
T
A
Q
H
-
R
Q
M
--
L
D
Q
V
L
--
S
I
F
G
---
I
T
P
D
F
D
L
N
I
M
K
D
----
R
Q
T
L
I
D
I
T
T
R
G
L
E
G
L
D
K
V
M
--
K
E
A
K
P
D
I
V
L
V
H
G
D
T
T
T
T
F
I
A
S
L
A
A
F
Y
N
Q
I
P
V
G
H
V
E
A
G
---
L
R
T
W
D
K
Y
-
S
P
----
Y
P
E
E
M
N
R
Q
L
T
G
V
M
A
D
L
H
F
S
P
-
T
A
K
S
A
T
N
L
Q
K
E
-
N
K
D
E
S
R
I
F
I
T
G
N
-
T
-
A
I
D
A
----
L
-----------
K
T
T
V
K
----
E
-----------
T
Y
S
H
P
V
L
-----
E
K
-
L
G
--
N
N
R
L
V
L
M
T
A
H
R
R
E
N
L
--
G
-
E
P
M
R
N
M
F
R
A
I
K
R
L
V
D
K
H
E
--
D
V
Q
V
V
Y
P
V
H
M
N
P
------
V
-
V
----
R
-
E
T
A
N
D
---
I
---
L
G
D
Y
G
R
I
H
L
I
---
E
P
---
L
D
V
I
D
F
H
N
V
A
A
---
R
S
Y
L
M
L
T
D
S
-----
G
G
V
Q
E
E
A
P
S
L
G
V
P
V
L
V
-
L
-
R
D
T
T
E
R
P
E
G
I
E
A
G
-
T
L
K
L
A
G
T
-
D
E
E
T
I
F
S
L
A
D
E
L
L
S
D
K
E
A
H
D
K
M
S
K
A
S
N
P
-
Y
G
D
-
G
-
R
A
S
E
R
I
V
E
A
I
L
K
H
F
-
N
K
---------
2
PsiBlast_PDB
87.40
67%
-86
- C2 -
3BEO
2
?
A:
[8-375]
---------------------------------
R
L
K
V
M
T
I
F
G
T
R
P
---
E
-----
A
I
K
M
A
P
L
V
L
E
L
Q
K
H
P
-
E
K
I
E
-
S
I
V
T
-
V
T
A
Q
H
-
R
Q
M
--
L
D
Q
V
L
--
S
I
F
G
---
I
T
P
D
F
D
L
N
I
M
K
D
----
R
Q
T
L
I
D
I
T
T
R
G
L
E
G
L
D
K
V
M
--
K
E
A
K
P
D
I
V
L
V
H
G
D
T
T
T
T
F
I
A
S
L
A
A
F
Y
N
Q
I
P
V
G
H
V
E
A
G
---
L
R
T
W
D
K
Y
-
S
P
----
Y
P
E
E
M
N
R
Q
L
T
G
V
M
A
D
L
H
F
S
P
-
T
A
K
S
A
T
N
L
Q
K
E
-
N
K
D
E
S
R
I
F
I
T
G
N
-
T
-
A
I
D
A
----
L
-----------
K
T
T
V
K
----
E
-----------
T
Y
S
H
P
V
L
-----
E
K
-
L
G
--
N
N
R
L
V
L
M
T
A
H
R
R
E
N
L
--
G
-
E
P
M
R
N
M
F
R
A
I
K
R
L
V
D
K
H
E
--
D
V
Q
V
V
Y
P
V
H
M
N
P
------
V
-
V
----
R
-
E
T
A
N
D
---
I
---
L
G
D
Y
G
R
I
H
L
I
---
E
P
---
L
D
V
I
D
F
H
N
V
A
A
---
R
S
Y
L
M
L
T
D
S
-----
G
G
V
Q
E
E
A
P
S
L
G
V
P
V
L
V
-
L
-
R
D
T
T
E
R
P
E
G
I
E
A
G
-
T
L
K
L
A
G
T
-
D
E
E
T
I
F
S
L
A
D
E
L
L
S
D
K
E
A
H
D
K
M
S
K
A
S
N
P
-
Y
G
D
-
G
-
R
A
S
E
R
I
V
E
A
I
L
K
H
F
-
N
K
---------
3
PsiBlast_PDB
86.23
62%
-79
- C2 -
4FKZ
2
MNAA_BACSU
A:
[2-377]
--------------------------------
K
K
L
K
V
M
T
V
F
G
T
R
P
---
E
-----
A
I
K
M
A
P
L
V
L
E
L
K
K
Y
P
-
E
-
I
D
-
S
Y
V
T
-
V
T
A
Q
H
-
R
Q
M
--
L
D
Q
V
L
--
D
A
F
H
---
I
K
P
D
F
D
L
N
I
M
K
E
----
R
Q
T
L
A
E
I
T
S
N
A
L
V
R
L
D
E
L
F
--
K
D
I
K
P
D
I
V
L
V
H
G
D
T
T
T
T
F
A
G
S
L
A
A
F
Y
H
Q
I
A
V
G
H
V
E
A
G
---
L
R
T
G
N
K
Y
-
S
P
----
F
P
E
E
L
N
R
Q
M
T
G
A
I
A
D
L
H
F
A
P
-
T
G
Q
A
K
D
N
L
L
K
E
-
N
K
K
A
D
S
I
F
V
T
G
N
-
T
-
A
I
D
A
----
L
-----------
N
T
T
V
R
----
D
-----------
G
Y
S
H
P
V
L
-----
D
Q
-
V
G
--
E
D
K
M
I
L
L
T
A
H
R
R
E
N
L
--
G
-
E
P
M
E
N
M
F
K
A
I
R
R
I
V
G
E
F
E
--
D
V
Q
V
V
Y
P
V
H
L
N
P
------
V
-
V
----
R
-
E
A
A
H
K
---
H
---
F
G
D
S
D
R
V
H
L
I
---
E
P
---
L
E
V
I
D
F
H
N
F
A
A
---
K
S
H
F
I
L
T
D
S
-----
G
G
V
Q
E
E
A
P
S
L
G
K
P
V
L
V
-
L
-
R
D
T
T
E
R
P
E
G
V
E
A
G
-
T
L
K
L
A
G
T
-
D
E
E
N
I
Y
Q
L
A
K
Q
L
L
T
D
P
D
E
Y
K
K
M
S
Q
A
S
N
P
-
Y
G
D
-
G
-
E
A
S
R
R
I
V
E
E
L
L
F
H
Y
G
Y
R
K
E
Q
P
D
S
F
--
21
PsiBlast_CBE
86.12
62%
-80
- C2 -
4FKZ
2
MNAA_BACSU
B:
[2-377]
--------------------------------
K
K
L
K
V
M
T
V
F
G
T
R
P
---
E
-----
A
I
K
M
A
P
L
V
L
E
L
K
K
Y
P
-
E
-
I
D
-
S
Y
V
T
-
V
T
A
Q
H
-
R
Q
M
--
L
D
Q
V
L
--
D
A
F
H
---
I
K
P
D
F
D
L
N
I
M
K
E
----
R
Q
T
L
A
E
I
T
S
N
A
L
V
R
L
D
E
L
F
--
K
D
I
K
P
D
I
V
L
V
H
G
D
T
T
T
T
F
A
G
S
L
A
A
F
Y
H
Q
I
A
V
G
H
V
E
A
G
---
L
R
T
G
N
K
Y
-
S
P
----
F
P
E
E
L
N
R
Q
M
T
G
A
I
A
D
L
H
F
A
P
-
T
G
Q
A
K
D
N
L
L
K
E
-
N
K
K
A
D
S
I
F
V
T
G
N
-
T
-
A
I
D
A
----
L
-----------
N
T
T
V
R
----
D
-----------
G
Y
S
H
P
V
L
-----
D
Q
-
V
G
--
E
D
K
M
I
L
L
T
A
H
R
R
E
N
L
--
G
-
E
P
M
E
N
M
F
K
A
I
R
R
I
V
G
E
F
E
--
D
V
Q
V
V
Y
P
V
H
L
N
P
------
V
-
V
----
R
-
E
A
A
H
K
---
H
---
F
G
D
S
D
R
V
H
L
I
---
E
P
---
L
E
V
I
D
F
H
N
F
A
A
---
K
S
H
F
I
L
T
D
S
-----
G
G
V
Q
E
E
A
P
S
L
G
K
P
V
L
V
-
L
-
R
D
T
T
E
R
P
E
G
V
E
A
G
-
T
L
K
L
A
G
T
-
D
E
E
N
I
Y
Q
L
A
K
Q
L
L
T
D
P
D
E
Y
K
K
M
S
Q
A
S
N
P
-
Y
G
D
-
G
-
E
A
S
R
R
I
V
E
E
L
L
F
H
Y
G
Y
R
K
E
Q
P
D
S
F
--
22
PsiBlast_CBE
83.58
49%
-89
- C2 -
3DZC
2
?
B:
[27-390]
-----------------------------------
K
V
L
I
V
F
G
T
R
P
---
E
-----
A
I
K
M
A
P
L
V
Q
Q
L
C
Q
D
--
N
R
F
V
-
A
K
V
C
-
V
T
G
Q
H
-
R
E
M
--
L
D
Q
V
L
--
E
L
F
S
---
I
T
P
D
F
D
L
N
I
M
E
P
----
G
Q
T
L
N
G
V
T
S
K
I
L
L
G
M
Q
Q
V
L
--
S
S
E
Q
P
D
V
V
L
V
H
G
D
T
A
T
T
F
A
A
S
L
A
A
Y
Y
Q
Q
I
P
V
G
H
V
E
A
G
---
L
R
T
G
N
I
Y
-
S
P
----
W
P
E
E
G
N
R
K
L
T
A
A
L
T
Q
Y
H
F
A
P
-
T
D
T
S
R
A
N
L
L
Q
E
-
N
Y
N
A
E
N
I
F
V
T
G
N
-
T
-
V
I
D
A
----
L
-----------
L
A
V
R
E
----
K
IHTDMDLQATL
E
S
Q
F
P
M
L
-----
D
---
A
--
S
K
K
L
I
L
V
T
G
H
R
R
E
S
F
--
G
-
G
G
F
E
R
I
C
Q
A
L
I
T
T
A
E
Q
H
P
--
E
C
Q
I
L
Y
P
V
H
L
N
P
------
N
-
V
----
R
-
E
P
V
N
K
---
L
---
L
K
G
V
S
N
I
V
L
I
---
E
P
---
Q
Q
Y
L
P
F
V
Y
L
M
D
---
R
A
H
I
I
L
T
D
S
-----
G
G
I
Q
E
E
A
P
S
L
G
K
P
V
L
V
-
M
-
R
E
T
T
E
R
P
E
A
V
A
A
G
-
T
V
K
L
V
G
T
-
N
Q
Q
Q
I
C
D
A
L
S
L
L
L
T
D
P
Q
A
Y
Q
A
M
S
Q
A
H
N
P
-
Y
G
D
-
G
-
K
A
C
Q
R
I
--------------------
7
PsiBlast_PDB
83.13
49%
-91
- C2 -
1VGV
-
WECB_ECOLI
A:
[2-372]
-----------------------------------
K
V
L
T
V
F
G
T
R
P
---
E
-----
A
I
K
M
A
P
L
V
H
A
L
A
K
D
P
--
F
F
E
-
A
K
V
C
-
V
T
A
Q
H
-
R
E
M
--
L
D
Q
V
L
--
K
L
F
S
---
I
V
P
D
Y
D
L
N
I
M
Q
P
----
G
Q
G
L
T
E
I
T
C
R
I
L
E
G
L
K
P
I
L
--
A
E
F
K
P
D
V
V
L
V
H
G
D
T
T
T
T
L
A
T
S
L
A
A
F
Y
Q
R
I
P
V
G
H
V
E
A
G
---
L
R
T
G
D
L
Y
-
S
P
----
W
P
E
E
A
N
R
T
L
T
G
H
L
A
M
Y
H
F
S
P
-
T
E
T
S
R
Q
N
L
L
R
E
-
N
V
A
D
S
R
I
F
I
T
G
N
-
T
-
V
I
D
A
----
L
L
W
V
R
D
QVMSS
D
K
L
R
S
E
----
L
-----------
A
A
N
Y
P
F
I
-----
D
---
P
--
D
K
K
M
I
L
V
T
G
H
R
R
E
S
F
--
G
-
R
G
F
E
E
I
C
H
A
L
A
D
I
A
T
T
H
Q
--
D
I
Q
I
V
Y
P
V
H
L
N
P
------
N
-
V
----
R
-
E
P
V
N
R
---
I
---
L
G
H
V
K
N
V
I
L
I
---
D
P
---
Q
E
Y
L
P
F
V
W
L
M
N
---
H
A
W
L
I
L
T
D
S
-----
G
G
I
Q
E
E
A
P
S
L
G
K
P
V
L
V
-
M
-
R
D
T
T
E
R
P
E
A
V
T
A
G
-
T
V
R
L
V
G
T
-
D
K
Q
R
I
V
E
E
V
T
R
L
L
K
D
E
N
E
Y
Q
A
M
S
R
A
H
N
P
-
Y
G
D
-
G
-
Q
A
C
S
R
I
L
E
A
L
K
N
N
-------------
6
PsiBlast_PDB
82.75
49%
-94
- C2 -
1F6D
3
WECB_ECOLI
A:
[2-372]
-----------------------------------
K
V
L
T
V
F
G
T
R
P
---
E
-----
A
I
K
M
A
P
L
V
H
A
L
A
K
D
P
--
F
F
E
-
A
K
V
C
-
V
T
A
Q
H
-
R
E
M
--
L
D
Q
V
L
--
K
L
F
S
---
I
V
P
D
Y
D
L
N
I
M
Q
P
----
G
Q
G
L
T
E
I
T
C
R
I
L
E
G
L
K
P
I
L
--
A
E
F
K
P
D
V
V
L
V
H
G
D
T
T
T
T
L
A
T
S
L
A
A
F
Y
Q
R
I
P
V
G
H
V
E
A
G
---
L
R
T
G
D
L
Y
-
S
P
----
W
P
E
E
A
N
R
T
L
T
G
H
L
A
M
Y
H
F
S
P
-
T
E
T
S
R
Q
N
L
L
R
E
-
N
V
A
D
S
R
I
F
I
T
G
N
-
T
-
V
I
D
A
----
L
L
W
V
R
DQVMSS
D
K
L
R
S
E
----
L
-----------
A
A
N
Y
P
F
I
-----
D
---
P
--
D
K
K
M
I
L
V
T
G
H
R
R
E
S
F
--
G
-
R
G
F
E
E
I
C
H
A
L
A
D
I
A
T
T
H
Q
--
D
I
Q
I
V
Y
P
V
H
L
N
P
------
N
-
V
----
R
-
E
P
V
N
R
---
I
---
L
G
H
V
K
N
V
I
L
I
---
D
P
---
Q
E
Y
L
P
F
V
W
L
M
N
---
H
A
W
L
I
L
T
D
S
-----
G
G
I
Q
E
E
A
P
S
L
G
K
P
V
L
V
-
M
-
R
D
T
T
E
R
P
E
A
V
T
A
G
-
T
V
R
L
V
G
T
-
D
K
Q
R
I
V
E
E
V
T
R
L
L
K
D
E
N
E
Y
Q
A
M
S
R
A
H
N
P
-
Y
G
D
-
G
-
Q
A
C
S
R
I
L
E
A
L
K
N
N
-------------
5
PsiBlast_PDB
82.38
49%
-87
- C2 -
3DZC
2
?
A:
[27-390]
-----------------------------------
K
V
L
I
V
F
G
T
R
P
---
E
-----
A
I
K
M
A
P
L
V
Q
Q
L
C
Q
D
--
N
R
F
V
-
A
K
V
C
-
V
T
G
Q
H
-
R
E
M
--
L
D
Q
V
L
--
E
L
F
S
---
I
T
P
D
F
D
L
N
I
M
E
P
----
G
Q
T
L
N
G
V
T
S
K
I
L
L
G
M
Q
Q
V
L
--
S
S
E
Q
P
D
V
V
L
V
H
G
D
T
A
T
T
F
A
A
S
L
A
A
Y
Y
Q
Q
I
P
V
G
H
V
E
A
G
---
L
R
T
G
N
I
Y
-
S
P
----
W
P
E
E
G
N
R
K
L
T
A
A
L
T
Q
Y
H
F
A
P
-
T
D
T
S
R
A
N
L
L
Q
E
-
N
Y
N
A
E
N
I
F
V
T
G
N
-
T
-
V
I
D
A
----
L
-----------
L
A
V
R
E
----
K
I
H
T
D
M
D
L
Q
A
T
L
E
S
Q
F
P
M
L
-----
D
---
A
--
S
K
K
L
I
L
V
T
G
H
R
R
E
S
F
--
G
-
G
G
F
E
R
I
C
Q
A
L
I
T
T
A
E
Q
H
P
--
E
C
Q
I
L
Y
P
V
H
L
N
P
------
N
-
V
----
R
-
E
P
V
N
K
---
L
---
L
K
G
V
S
N
I
V
L
I
---
E
P
---
Q
Q
Y
L
P
F
V
Y
L
M
D
---
R
A
H
I
I
L
T
D
S
-----
G
G
I
Q
E
E
A
P
S
L
G
K
P
V
L
V
-
M
-
R
E
T
T
E
R
P
E
A
V
A
A
G
-
T
V
K
L
V
G
T
-
N
Q
Q
Q
I
C
D
A
L
S
L
L
L
T
D
P
Q
A
Y
Q
A
M
S
Q
A
H
N
P
-
Y
G
D
-
G
-
K
A
C
Q
R
I
--------------------
25
HHSearch
80.89
47%
-88
- C2 -
3DZC
2
?
A:
[24-395]
--------------------------------
A
M
K
K
V
L
I
V
F
G
T
R
P
---
E
-----
A
I
K
M
A
P
L
V
Q
Q
L
C
Q
D
--
N
-
R
F
V
A
K
V
C
-
V
T
G
Q
H
-
R
E
M
--
L
D
Q
V
L
--
E
L
F
S
---
I
T
P
D
F
D
L
N
I
M
E
P
----
G
Q
T
L
N
G
V
T
S
K
I
L
L
G
M
Q
Q
V
L
--
S
S
E
Q
P
D
V
V
L
V
H
G
D
T
A
T
T
F
A
A
S
L
A
A
Y
Y
Q
Q
I
P
V
G
H
V
E
A
G
---
L
R
T
G
N
I
Y
-
S
P
----
W
P
E
E
G
N
R
K
L
T
A
A
L
T
Q
Y
H
F
A
P
-
T
D
T
S
R
A
N
L
L
Q
E
-
N
Y
N
A
E
N
I
F
V
T
G
N
-
T
-
V
I
D
A
----
L
-----------
L
A
V
R
E
----
K
I
H
T
D
M
D
L
Q
---
A
T
L
E
S
Q
F
-----
P
M
L
D
A
--
S
K
K
L
I
L
V
T
G
H
R
R
E
S
F
--
G
-
G
G
F
E
R
I
C
Q
A
L
I
T
T
A
E
Q
H
P
--
E
C
Q
I
L
Y
P
V
H
L
N
P
------
N
-
V
----
R
-
E
P
V
N
K
---
L
---
L
K
G
V
S
N
I
V
L
I
---
E
P
---
Q
Q
Y
L
P
F
V
Y
L
M
D
---
R
A
H
I
I
L
T
D
S
-----
G
G
I
Q
E
E
A
P
S
L
G
K
P
V
L
V
-
M
-
R
E
T
T
E
R
P
E
A
V
A
A
G
-
T
V
K
L
V
G
T
-
N
Q
Q
Q
I
C
D
A
L
S
L
L
L
T
D
P
Q
A
Y
Q
A
M
S
Q
A
H
-----
N
-
P
-
Y
G
D
G
K
A
C
Q
R
I
A
D
I
L
-
A
----------
8
PsiBlast_PDB
79.28
41%
-90
- C2 -
1V4V
2
?
A:
[7-375]
-----------------------------------
R
V
V
L
A
F
G
T
R
P
---
E
-----
A
T
K
M
A
P
V
Y
L
A
L
R
G
I
P
--
G
L
K
-
P
L
V
L
-
L
T
G
Q
H
-
R
E
Q
--
L
R
Q
A
L
--
S
L
F
G
---
I
Q
E
D
R
N
L
D
V
M
Q
E
----
R
Q
A
L
P
D
L
A
A
R
I
L
P
Q
A
A
R
A
L
--
K
E
M
G
A
D
Y
V
L
V
H
G
D
T
L
T
T
F
A
V
A
W
A
A
F
L
E
G
I
P
V
G
H
V
E
A
G
---
L
R
S
G
N
L
K
-
E
P
----
F
P
E
E
A
N
R
R
L
T
D
V
L
T
D
L
D
F
A
P
-
T
P
L
A
K
A
N
L
L
K
E
-
G
K
R
E
E
G
I
L
V
T
G
Q
-
T
-
G
V
D
A
----
V
-----------
L
L
A
A
K
----
L
-----------
G
R
---
L
P
-----
E
G
-
L
P
--
E
G
P
Y
V
T
V
T
M
H
R
R
E
N
W
----
P
L
L
S
D
L
A
Q
A
L
K
R
V
A
E
A
F
P
--
H
L
T
F
V
Y
P
V
H
L
N
P
------
V
-
V
----
R
-
E
A
V
F
P
---
V
---
L
K
G
V
R
N
F
V
L
L
---
D
P
---
L
E
Y
G
S
M
A
A
L
M
R
---
A
S
L
L
L
V
T
D
S
-----
G
G
L
Q
E
E
G
A
A
L
G
V
P
V
V
V
-
L
-
R
N
V
T
E
R
P
E
G
L
K
A
G
-
I
L
K
L
A
G
T
-
D
P
E
G
V
Y
R
V
V
K
G
L
L
E
N
P
E
E
L
S
R
M
R
K
A
K
N
P
-
Y
G
D
-
G
-
K
A
G
L
M
V
A
R
G
V
A
W
R
L
-
G
L
G
P
R
P
E
D
W
L
-
26
HHSearch
77.46
46%
-85
- C2 -
1VGV
-
WECB_ECOLI
A:
[1-372]
----------------------------------
M
K
V
L
T
V
F
G
T
R
P
---
E
-----
A
I
K
M
A
P
L
V
H
A
L
A
K
D
P
-
F
-
F
E
-
A
K
V
C
-
V
T
A
Q
H
-
R
E
M
--
L
D
Q
V
L
--
K
L
F
S
---
I
V
P
D
Y
D
L
N
I
M
Q
P
----
G
Q
G
L
T
E
I
T
C
R
I
L
E
G
L
K
P
I
L
--
A
E
F
K
P
D
V
V
L
V
H
G
D
T
T
T
T
L
A
T
S
L
A
A
F
Y
Q
R
I
P
V
G
H
V
E
A
G
---
L
R
T
G
D
L
Y
-
S
P
----
W
P
E
E
A
N
R
T
L
T
G
H
L
A
M
Y
H
F
S
P
-
T
E
T
S
R
Q
N
L
L
R
E
-
N
V
A
D
S
R
I
F
I
T
G
N
-
T
-
V
I
D
A
----
L
-----------
L
W
V
R
D
QVMS
S
-----------
D
K
L
R
S
E
L
A
A
NYP
F
I
-
D
P
--
D
K
K
M
I
L
V
T
G
H
R
R
E
S
F
--
G
-
R
G
F
E
E
I
C
H
A
L
A
D
I
A
T
T
H
Q
--
D
I
Q
I
V
-
Y
P
V
H
L
N
------
P
-
N
----
V
R
E
P
V
N
R
---
I
---
L
G
H
V
K
N
V
I
L
I
---
D
P
---
Q
E
Y
L
P
F
V
W
L
M
N
---
H
A
W
L
I
L
T
D
S
-----
G
G
I
Q
E
E
A
P
S
L
G
K
P
V
L
V
M
R
-
D
-
T
T
E
R
P
E
A
V
T
A
G
-
T
V
R
L
V
G
T
-
D
K
Q
R
I
V
E
E
V
T
R
L
L
K
D
E
N
E
Y
Q
A
M
S
R
A
-----
H
N
-
P
-
Y
G
D
G
Q
A
C
S
R
I
L
E
A
L
-
K
N
N
--------
24
HHSearch
75.13
39%
-86
- C2 -
1V4V
2
?
A:
[4-374]
--------------------------------
G
M
K
R
V
V
L
A
F
G
T
R
P
---
E
-----
A
T
K
M
A
P
V
Y
L
A
L
R
G
I
P
-
G
-
L
K
-
P
L
V
L
-
L
T
G
Q
H
-
R
E
Q
--
L
R
Q
A
L
--
S
L
F
G
---
I
Q
E
D
R
N
L
D
V
M
Q
E
----
R
Q
A
L
P
D
L
A
A
R
I
L
P
Q
A
A
R
A
L
--
K
E
M
G
A
D
Y
V
L
V
H
G
D
T
L
T
T
F
A
V
A
W
A
A
F
L
E
G
I
P
V
G
H
V
E
A
G
---
L
R
S
G
N
L
K
-
E
P
----
F
P
E
E
A
N
R
R
L
T
D
V
L
T
D
L
D
F
A
P
-
T
P
L
A
K
A
N
L
L
K
E
-
G
K
R
E
E
G
I
L
V
T
G
Q
T
G
-
V
D
A
V
----
L
-----------
L
A
A
K
L
----------------
G
R
--
L
P
E
-----
G
L
-
P
E
--
G
P
Y
V
T
V
T
M
H
R
R
E
N
----
W
-
P
L
L
S
D
L
A
Q
A
L
K
R
V
A
E
A
F
P
--
H
L
T
F
V
-
Y
P
V
H
L
N
------
P
V
V
----
R
-
E
A
V
F
P
---
V
---
L
K
G
V
R
N
F
V
L
L
---
D
P
---
L
E
Y
G
S
M
A
A
L
M
R
---
A
S
L
L
L
V
T
D
S
-----
G
G
L
Q
E
E
G
A
A
L
G
V
P
V
V
V
-
L
R
N
-
V
T
E
R
P
E
G
L
K
A
G
-
I
L
K
L
A
G
T
-
D
P
E
G
V
Y
R
V
V
K
G
L
L
E
N
P
E
E
L
S
R
M
R
K
A
K
N
P
-
Y
G
D
-
G
-
K
A
G
L
M
V
A
R
G
V
A
W
R
L
-
G
L
G
P
R
P
E
D
W
--
9
PsiBlast_PDB
69.43
36%
-79
- C2 -
4NEQ
1
WECB_METJA
A:
[2-358]
-----------------------------------
K
L
S
I
I
L
G
T
R
P
---
E
-----
I
I
K
L
S
P
I
I
R
A
L
E
K
T
---
N
I
D
-
W
H
I
I
-
H
T
N
-----
N
--
M
D
K
I
F
F
E
E
L
N
L
---
P
N
P
K
Y
N
L
N
I
--
G
----
S
G
T
H
G
E
Q
T
G
K
M
L
I
E
I
E
K
V
L
--
L
K
E
K
P
D
V
V
V
V
Q
G
D
T
N
T
V
L
A
G
A
L
V
A
S
K
L
K
I
D
V
A
H
V
E
A
G
---
L
R
S
F
D
R
N
-
M
P
------
E
E
I
N
R
V
L
T
D
H
I
S
S
Y
L
F
A
P
-
T
E
I
A
K
N
N
L
L
R
E
-
G
I
E
E
N
K
I
F
V
V
G
N
-
T
-
I
V
D
A
T
L
Q
N
L
-----------
K
I
A
E
K
----
N
-----------
E
N
V
R
A
F
F
-----
N
S
-
V
V
I-
D
D
D
Y
F
L
L
T
L
H
R
A
E
N
V
DN
K
-
E
R
L
K
N
I
V
E
G
I
F
E
I
I
E
I
Y
---
D
K
A
I
I
F
S
I
H
P
R
T
------
K
-
K
----
R
-
L
K
E
F
N
---
L
F
D
K
L
K
S
N
K
K
I
K
I
I
---
E
P
---
V
G
Y
L
E
F
L
M
L
E
K
---
N
A
E
L
I
L
T
D
S
-----
G
G
V
Q
E
E
A
C
I
L
K
V
P
C
I
T
-
L
-
R
D
N
T
E
R
P
E
T
V
E
V
G
-
A
N
I
L
V
G
D
-
N
K
E
K
L
I
K
-
A
V
E
I
M
L
N
K
K
R
N
W
K
-----
N
P
-
F
G
N
-
G
-
K
S
G
E
R
I
V
-------------------
10
PsiBlast_PDB
68.12
36%
-69
- C2 -
4NES
2
WECB_METJA
A:
[2-358]
-----------------------------------
K
L
S
I
I
L
G
T
R
P
---
E
-----
I
I
K
L
S
P
I
I
R
A
L
E
K
T
---
N
I
D
-
W
H
I
I
-
H
T
N
Q
H
Y
S
E
N
--
M
D
K
I
F
F
E
E
L
N
L
---
P
N
P
K
Y
N
L
N
I
--
G
----
S
G
T
H
G
E
Q
T
G
K
M
L
I
E
I
E
K
V
L
--
L
K
E
K
P
D
V
V
V
V
Q
G
D
T
N
T
V
L
A
G
A
L
V
A
S
K
L
K
I
D
V
A
H
V
E
A
G
---
L
R
S
F
D
R
N
-
M
P
------
E
E
I
N
R
V
L
T
D
H
I
S
S
Y
L
F
A
P
-
T
E
I
A
K
N
N
L
L
R
E
-
G
I
E
E
N
K
I
F
V
V
G
N
-
T
-
I
V
D
A
T
L
Q
N
L
-----------
K
I
A
E
K
----
N
-----------
E
N
V
R
A
F
F
-----
N
S
-
V
V
---
D
D
Y
F
L
L
T
L
H
R
A
E
N
V
DN
K
-
E
R
L
K
N
I
V
E
G
I
F
E
I
I
E
I
Y
---
D
K
A
I
I
F
S
I
H
P
R
T
------
K
-
K
----
R
-
L
K
E
F
N
---
L
F
D
K
L
K
S
N
K
K
I
K
I
I
---
E
P
---
V
G
Y
L
E
F
L
M
L
E
K
---
N
A
E
L
I
L
T
D
S
-----
G
G
V
Q
E
E
A
C
I
L
K
V
P
C
I
T
-
L
-
R
D
N
T
E
R
P
E
T
V
E
V
G
-
A
N
I
L
V
G
D
-
N
K
E
K
L
I
K
-
A
V
E
I
M
L
N
K
K
R
N
W
K
-----
N
P
-
F
G
N
-
G
-
K
S
G
E
R
I
V
-------------------
11
PsiBlast_PDB
65.78
27%
-73
- C2 -
4HWG
1
?
A:
[10-379]
----------------------------------
L
K
V
M
T
I
V
G
T
R
P
---
E
-----
L
I
K
L
C
C
V
I
S
E
F
D
K
H
T
-
K
----
H
I
L
V
-
H
T
G
Q
N
-
Y
A
Y
E
-
L
N
Q
V
F
----
F
D
MGI
R
K
P
D
Y
F
L
E
V
--
A
----
A
D
N
T
A
K
S
I
G
L
V
I
E
K
V
D
E
V
L
--
E
K
E
K
P
D
A
V
L
F
Y
G
D
T
N
S
C
L
S
A
-
I
A
A
K
R
R
K
I
P
I
F
H
M
E
A
G
---
N
R
C
F
D
Q
---
R
----
V
P
E
E
I
N
R
K
I
I
D
H
I
S
D
V
N
I
T
L
-
T
E
H
A
R
R
Y
L
I
A
E
-
G
L
P
A
E
L
T
F
K
S
G
S
-
H
-
M
P
E
V
----
L
-----------
D
R
F
M
P
----
K
-----------
I
L
K
S
D
I
L
-----
D
K
-
L
S
LT
P
K
Q
Y
F
L
I
S
S
H
R
E
------K
N
N
L
K
E
L
L
N
S
L
Q
M
L
I
K
E
Y
---
N
F
L
I
I
F
S
T
H
--
P
------
R
-
T
----
K
-
K
R
L
E
D
---
L
---
E
G
F
K
E
L
G
D
K
I
---
R
F
---
L
P
A
F
S
F
T
D
Y
V
K
L
Q
M
N
A
F
C
I
L
S
D
S
-----
G
T
I
T
E
E
A
S
I
L
N
L
P
A
L
N
-
I
-
R
E
A
H
E
R
P
E
G
M
D
A
G
-
T
L
I
M
S
G
F
-
K
A
E
R
V
L
-
Q
A
V
K
T
I
T
E
E
H
D
N
N
K
R
T
Q
G
L
V
P
D
Y
N
E
A
G
-
L
V
S
K
K
I
L
R
I
V
L
S
Y
V
-
D
Y
I
N
R
------
27
HHSearch
52.98
17%
-66
- C2 -
3C48
3
MSHA_CORGL
A:
[19-425]
--------------------------------
S
H
M
R
V
A
M
I
S
M
H
T
S
---
P
LQQG
M
N
V
Y
I
L
S
T
A
T
E
L
A
K
Q
--
G
-
I
E
-
V
D
I
Y
-
T
R
A
T
R
-
P
S
Q
GE
I
V
R
V
A
--
E
--
N
---
L
-
R
V
I
N
I
A
A
G
P
Y
EGLS
K
E
E
L
P
T
Q
L
A
A
F
T
G
G
M
L
S
F
T
R
R
E
K
V
T
Y
D
L
I
H
S
H
Y
W
L
S
G
Q
V
-
G
W
L
L
R
D
L
W
R
I
P
L
I
H
T
A
H
T
---
L
A
A
V
K
N
S
Y-
D
T
P
E
S
E
A
R
R
I
C
E
Q
Q
L
V
D
N
A
D
V
L
A
V
N
-
T
Q
E
E
M
Q
D
L
M
H
H
Y
D
A
D
P
D
R
I
S
V
V
S
P
-
G
-
A
D
V
E
----
L
-----------
Y
S
P
G
------T----------
E
R
S
R
R
E
L
-----
G
I
-
P
L
--
H
T
K
V
V
A
F
V
G
R
L
Q
P
----
F
-
K
G
P
Q
V
L
I
K
A
V
A
A
L
F
D
R
D
P
DR
N
L
R
V
I
-
I
C
G
G
P
S
---------------
D
T
Y
R
H
M
A
E
E
---
L
G
V
E
K
R
I
R
F
L
---
D
P
---
R
P
P
S
E
L
V
A
V
Y
R
---
A
A
D
I
V
A
V
P
S
FNESF
G
L
V
A
M
E
A
Q
A
S
G
T
P
V
I
A
-
A
-
R
-
V
G
G
L
P
I
A
V
A
E
G
E
T
G
L
L
V
D
G
H
S
P
H
A
W
A
D
A
L
A
T
L
L
D
D
D
E
T
R
I
R
M
G
E
D
A
V
E
-
H
A
R
-
T
-
F
S
W
A
A
T
A
A
Q
L
S
S
L
Y
-
N
D
A
--------
47
Fugue
52.62
16%
-60
- C2 -
2X6Q
-
TRET_PYRHO
A:
[2-414]
K
M
Y
E
V
KKRKLEDYKSIIG
E
E
E
V
S
K
I
Q
E
K
A
E
K
L
K
G
R
S
F
V
H
V
N
S
T
S
F
GGG
V
-----
A
E
I
L
H
S
L
V
P
L
L
R
S
I
G
-
I
E
A
R
-
W
F
V
I
E
G
P
T
E
F
-
F
N
V
--
T
K
T
F
H
--
N
A
L
Q
---
G
N
E
S
L
K
L
T
---------
E
E
M
K
E
L
Y
L
N
V
N
R
E
N
S
K
F
I
--
D
L
S
S
F
D
Y
V
L
V
H
D
P
Q
P
A
A
L
I
E
F
Y
E
K
K
S
P
W
L
W
R
C
H
I
D
L
S
SPN
R
E
F
W
E
F
L
-
R
R
----
F
V
E
K
Y
D
R
Y
I
F
H
-
L
P
E
Y
V
Q
P
E
-
L
D
R
N
K
A
V
I
M
P
P
-
S
I
D
P
------------
L
S
E
----
K
-----------
N
V
E
L
K
----
Q
-----------
T
E
I
L
R
I
L
-----
E
R
-
F
D
V-
D
P
E
K
P
I
I
T
Q
V
S
R
F
D
P
--
W
-
K
G
I
F
D
V
I
E
I
Y
R
K
V
K
E
K
I
P
--
G
V
Q
L
L
L
V
G
V
M
A
H
DD
P
E
G
W
I
-
Y
----
F
-
E
K
T
L
R
---
K
---
I
G
E
D
Y
D
V
K
V
L
TNL
I
G
---
V
H
A
R
E
V
N
A
F
Q
R
---
A
S
D
V
I
L
Q
M
S
IREGF
G
L
T
V
T
E
A
M
W
K
G
K
P
V
I
G
-
R
-
A
V
G
G
I
K
F
Q
-
I
V
D
G
-
E
T
G
F
L
V
R
-
D
A
N
E
A
V
E
V
V
L
Y
L
L
K
H
P
E
V
S
K
E
M
G
A
K
A
K
E
-
R
V
R
-
K
N
F
I
I
T
K
H
M
E
R
Y
L
D
I
L
-
N
S
L
--------
41
HHSearch
52.38
15%
-60
- C2 -
2X6Q
-
TRET_PYRHO
A:
[39-414]
--------------------------------
K
G
R
S
F
V
H
V
N
S
T
S
F
---
G
GG
V
--
A
E
I
L
H
S
L
V
P
L
L
R
S
I
--
G
-
I
E
-
A
R
W
F
-
V
I
E
G
P
-
T
E
---
F
F
N
V
T
--
K
T
F
H
---
N
-
A
L
Q
G
N
E
S
L
K
L
----
T
E
E
M
K
E
L
Y
L
N
V
N
R
E
N
S
K
F
I
--
D
L
S
S
F
D
Y
V
L
V
H
D
P
Q
P
A
A
L
I
-
E
F
--
Y
E
K
K
S
P
W
L
W
R
C
H
I
---
D
L
S
S
P
-
N
-
R
E
----
F
W
-
E
F
L
R
R
F
-
V
E
K
Y
D
R
Y
I
F
H
L
P
E
Y
V
Q
P
E
------
L
D
R
N
K
A
V
I
M
P
P
-
S
-
I
D
P
L
----
S
-----------
E
K
N
V
E
----
L
K
Q
T
E
I
------
L
R
I
L
E
R
F
-----
D
V
-
D
P
--
E
K
P
I
I
T
Q
V
S
R
F
D
P
----
W
-
K
G
I
F
D
V
I
E
I
Y
R
K
V
K
E
K
I
P
--
G
V
Q
L
L
-
L
V
G
V
M
A
------
H
-
D
D
P
E
G
W
-
I
Y
F
E
K
T
L
R
K
---
I
G
E
D
Y
D
V
K
V
L
---
T
N
LIG
V
H
A
R
E
V
N
A
F
Q
R
---
A
S
D
V
I
L
Q
M
S
IREGF
G
L
T
V
T
E
A
M
W
K
G
K
P
V
I
G
-
R
-
A
-
V
G
G
I
K
F
Q
I
V
D
G
E
T
G
F
L
V
R
--
D
A
N
E
A
V
E
V
V
L
Y
L
L
K
H
P
E
V
S
K
E
M
G
A
K
A
K
E
-
R
V
R
K
N
-
F
I
I
T
K
H
M
E
R
Y
L
D
I
L
-
N
S
L
--------