@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu23360: (2016-07-06 )
MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTFHRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFIVHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG
Atome Classification :
(105 SA)
.........10........20........30....---------------...--------.40........50.....-...60-.....----------------------------.-..70........80-.--.-..--....90-.---.......100.......110-----.......120.-.-.....130---.........140.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
T
G
Y
F
L
LEDG
N
K
I
E
F
E
LYPEAAPG
T
V
A
N
F
E
K
L
A
N---------------EGF--------YDG
L
T
F
H
R
V
I
P
G
F
VSQGG-CPHGT-GTGGP----------------------------
G
-
Y
T
I
K
C
ETEGNPHTH-E--A-G
A
--
L
S
M
A
HA-G---KDTGG
S
Q
F
F
I
V
HEPQPHL
N
G
-----
V
H
T
V
F
G
K
V
T
S
G
-
L
-
E
F
A
K
NM-----SN
G
D
V
M
K
E
VRVEG
1
PsiBlast_PDB
96.29
75%
-77
- C5 -
2MVZ
-
?
A:
[3-142]
-
K
K
G
Y
I
L
M
E
N
G
G
K
I
E
F
E
L
F
P
N
E
A
P
V
T
V
A
N
F
E
K
L
A
N
---------------
E
G
F
--------
Y
N
G
L
T
F
H
R
V
I
P
G
F
V
S
Q
G
G
-
C
P
R
G
N
-
G
T
G
D
A
----------------------------
G
-
Y
T
I
P
C
E
T
D
N
N
P
H
R
H
-
V
--
T
-
G
A
--
M
S
M
A
H
R
-
G
---
R
D
T
G
S
C
Q
F
F
I
V
H
E
P
Q
P
H
L
D
G
-----
V
H
T
V
F
G
Q
V
T
S
G
-
M
-
D
V
V
R
T
M
-----
K
N
G
D
V
M
K
E
V
K
V
--
101
HHSearch
91.20
74%
-43
- C5 -
2MVZ
-
?
A:
[3-144]
-
K
K
G
Y
I
L
M
E
N
G
G
K
I
E
F
E
L
F
P
N
E
A
P
V
T
V
A
N
F
E
K
L
A
N
---------------
E
G
F
--------
Y
N
G
L
T
F
H
R
V
I
P
G
F
V
S
Q
G
G
-
C
P
R
G
N
-
G
T
G
D
A
----------------------------
G
-
Y
T
I
P
C
E
T
D
N
N
P
H
R
H
-
V
--
T
-
G
A
--
M
S
M
A
H
R
-
G
---
R
D
T
G
S
C
Q
F
F
I
V
H
E
P
Q
P
H
L
D
G
-----
V
H
T
V
F
G
Q
V
T
S
--
G
M
D
V
V
R
T
M
-----
K
N
G
D
V
M
K
E
V
K
V
F
D
115
HHSearch
71.26
44%
-15
- C5 -
1W74
-
PPIA_MYCTU
A:
[15-163]
--
A
T
A
T
L
H
T
N
R
G
D
I
K
I
A
L
F
G
N
H
A
P
K
T
V
A
N
F
V
G
L
A
Q
GTKDYSTQNASGGPS
G
P
F
--------
Y
D
G
A
V
F
H
R
V
I
Q
G
F
M
I
Q
G
G
-
D
P
T
G
T
-
G
R
G
G
P
----------------------------
G
-
Y
K
F
A
D
E
F
H
P
E
L
Q
F
D
-
K
--
P
-
Y
L
--
L
A
M
A
N
A
-
G
---
P
G
T
N
G
S
Q
F
F
I
T
V
G
K
T
P
H
L
N
R
-----
R
H
T
I
F
G
E
V
I
D
A
E
S
Q
R
V
V
E
A
I
-----
S
K
T
A
---------
109
HHSearch
70.82
42%
-33
- C5 -
2A2N
1
PPWD1_HUMAN
A:
[23-157]
---
S
A
I
I
H
T
S
M
G
D
I
H
T
K
L
F
P
V
E
C
P
K
T
V
E
N
F
C
V
H
S
R
---------------
N
G
Y
--------
Y
N
G
H
T
F
H
R
I
I
K
G
F
M
I
Q
T
G
-
D
P
T
G
T
-
G
M
G
G
E
S
IW-------------------------
G
-
G
E
F
E
D
E
F
H
S
T
L
R
H
D
-
R
--
P
-
Y
T
--
L
S
M
A
N
A
-
G
---
S
N
T
N
G
S
Q
F
F
I
T
V
V
P
T
P
W
L
D
N
-----
K
H
T
V
F
G
R
V
T
K
--
G
M
E
V
V
Q
R
I
-----
S
N
V
K
V
--------
111
HHSearch
69.05
39%
-8
- C5 -
2HQ6
2
CWC27_HUMAN
A:
[25-160]
--
G
K
V
L
L
K
T
T
A
G
D
I
D
I
E
L
W
S
K
E
A
P
K
A
C
R
N
F
I
Q
L
C
L
---------------
E
A
Y
--------
Y
D
N
T
I
F
H
R
V
V
P
G
F
I
V
Q
G
G
-
D
P
T
G
T
-
G
S
G
G
E
S
IY-------------------------
G
-
A
P
F
K
D
E
F
H
S
R
L
R
F
N
-
R
--
R
-
G
L
--
V
A
M
A
N
A
-
G
---
S
H
D
N
G
S
Q
F
F
F
T
L
G
R
A
D
E
L
N
N
-----
K
H
T
I
F
G
K
V
T
G
D
-
T
V
Y
N
M
L
R
L
-----
S
E
V
D
---------
106
HHSearch
68.25
37%
-5
- C5 -
2POE
4
?
A:
[17-155]
--
Q
G
V
R
I
I
T
N
Y
G
D
L
K
F
E
L
F
C
S
Q
C
P
K
A
C
K
N
F
L
A
L
S
A
---------------
S
G
Y
--------
Y
K
N
T
I
F
H
K
N
I
K
G
F
I
I
Q
G
G
-
D
P
T
G
T
-
G
K
G
G
E
S
IY-------------------------
G
-
R
Y
F
D
D
E
I
Y
P
E
L
K
Y
D
-
R
--
R
-
G
I
--
L
S
M
A
S
K
-
G
AKK
P
N
T
N
G
S
Q
F
F
I
T
Y
S
S
L
P
Q
L
N
G
-----
E
Y
V
I
F
G
K
L
I
D
--
G
F
E
T
L
N
T
L
-----
E
N
C
P
---------
104
HHSearch
67.41
35%
-35
- C5 -
2FU0
-
?
A:
[5-140]
-
P
K
S
A
I
I
Y
T
T
M
G
D
I
H
I
S
L
F
Y
K
E
C
K
K
T
V
Q
N
F
S
V
H
S
I
---------------
N
G
Y
--------
Y
N
N
C
I
F
H
R
V
I
K
H
F
M
V
Q
T
G
-
D
P
S
G
D
-
G
T
G
G
E
S
IW-------------------------
G
-
N
E
F
E
D
E
F
F
D
H
L
N
H
S
-
K
--
P
-
F
M
--
V
S
M
A
N
C
-
G
---
P
N
T
N
G
S
Q
F
F
I
T
T
V
P
C
P
W
L
D
F
-----
K
H
T
V
F
G
K
V
T
Q
--
G
S
K
I
V
L
D
I
-----
E
K
V
R
---------
21
PsiBlast_CBE
67.24
44%
-31
- C5 -
2A2N
1
C:
[33-157]
-------------
I
H
T
K
L
F
P
V
E
C
P
K
T
V
E
N
F
C
V
H
S
R
---------------
N
G
Y
--------
Y
N
G
H
T
F
H
R
I
I
K
G
F
M
I
Q
T
G
-
D
P
T
G
T
-
G
M
G
G
E
SIW-------------------------
G
-
G
E
F
E
D
E
F
H
S
T
L
R
H
D
-
R
--
P
-
Y
T
--
L
S
M
A
N
A
-
G
---
S
N
T
N
G
S
Q
F
F
I
T
V
V
P
T
P
W
L
D
N
-----
K
H
T
V
F
G
R
V
T
K
G
-
M
-
E
V
V
Q
R
I
-----
S
N
V
K
V
--------
108
HHSearch
67.12
41%
-14
- C5 -
2B71
5
?
A:
[39-173]
--
G
Y
I
T
I
Y
T
N
L
G
D
F
E
V
E
L
Y
W
Y
H
S
P
K
T
C
L
N
F
Y
T
L
C
E
---------------
M
G
F
--------
Y
D
N
T
I
F
H
R
V
I
P
N
F
V
I
Q
G
G
-
D
P
T
G
T
-
G
K
G
G
K
S
IY-------------------------
G
-
E
Y
F
E
D
E
I
N
K
E
L
K
H
T
-
G
--
A
-
G
I
--
L
S
M
S
N
N
-
G
---
P
N
T
N
S
S
Q
F
F
I
T
L
A
P
L
P
H
L
D
G
-----
K
H
T
I
F
A
R
V
S
K
--
N
M
T
C
I
E
N
I
-----
A
S
V
Q
---------
116
HHSearch
66.97
37%
-7
- C5 -
1V9T
-
PPIA_ECOLI
A:
[5-143]
--
P
H
V
L
L
T
T
S
A
G
N
I
E
L
E
L
D
K
Q
K
A
P
V
S
V
Q
N
F
V
D
Y
V
N
---------------
S
G
F
--------
Y
N
N
T
T
F
H
R
V
I
P
G
F
M
I
Q
G
G
-
G
F
T
E
Q
M
Q
Q
K
K
P
----------------------------
N
-
P
P
I
K
N
E
A
D
N
-
G
L
R
N
-
T
--
R
-
G
T
--
I
A
M
A
R
T
A
D
---
K
D
S
A
T
S
Q
F
F
I
N
V
A
D
N
A
F
L
D
H
GQRDF
G
Y
A
V
F
G
K
V
V
K
--
G
M
D
V
A
D
K
I
-----
S
Q
V
P
T
--------
6
PsiBlast_PDB
66.85
44%
-30
- C5 -
2A2N
1
PPWD1_HUMAN
A:
[33-157]
-------------
I
H
T
K
L
F
P
V
E
C
P
K
T
V
E
N
F
C
V
H
S
R
---------------
N
G
Y
--------
Y
N
G
H
T
F
H
R
I
I
K
G
F
M
I
Q
T
G
-
D
P
T
G
T
-
G
M
G
G
E
S
IW-------------------------
G
-
G
E
F
E
D
E
F
H
S
T
L
R
H
D
-
R
--
P
-
Y
T
--
L
S
M
A
N
A
-
G
---
S
N
T
N
G
S
Q
F
F
I
T
V
V
P
T
P
W
L
D
N
-----
K
H
T
V
F
G
R
V
T
K
G
-
M
-
E
V
V
Q
R
I
-----
S
N
V
K
V
--------
117
HHSearch
66.80
40%
-10
- C5 -
2OK3
1
PPIL3_HUMAN
A:
[2-136]
---
S
V
T
L
H
T
D
V
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
L
A
L
C
A
---------------
S
N
Y
--------
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
-
D
P
T
G
T
-
G
R
G
G
N
S
IW-------------------------
G
-
K
K
F
E
D
E
Y
S
E
Y
L
K
H
N
-
V
--
R
-
G
V
--
V
S
M
A
N
N
-
G
---
P
N
T
N
G
S
Q
F
F
I
T
Y
G
K
Q
P
H
L
D
M
-----
K
Y
T
V
F
G
K
V
I
D
--
G
L
E
T
L
D
E
L
-----
E
K
L
P
V
--------
2
PsiBlast_PDB
66.75
46%
-22
- C5 -
2B71
5
?
A:
[51-171]
--------------
E
V
E
L
Y
W
Y
H
S
P
K
T
C
L
N
F
Y
T
L
C
E
---------------
M
G
F
--------
Y
D
N
T
I
F
H
R
V
I
P
N
F
V
I
Q
G
G
-
D
P
T
G
T
-
G
K
G
G
K
----------------------------
S
I
Y
G
E
Y
F
E
D
E
I
N
K
E
L
K
-
H
--
T
-
G
A
G
I
L
S
M
S
N
N
-
G
---
P
N
T
N
S
S
Q
F
F
I
T
L
A
P
L
P
H
L
D
G
-----
K
H
T
I
F
A
R
V
S
K
N
-
M
-
T
C
I
E
N
I
-----
A
S
-----------
9
PsiBlast_PDB
66.71
44%
-11
- C5 -
1XYH
-
PPIL3_HUMAN
A:
[5-126]
------
L
H
T
D
V
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
L
A
L
C
A
---------------
S
N
Y
--------
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
-
D
P
T
G
T
-
G
R
G
G
N
----------------------------
S
I
W
G
K
K
F
E
D
E
Y
S
E
Y
L
K
-
H
NV
R
-
G
V
--
V
S
M
A
N
N
-
G
---
P
N
T
N
G
S
Q
F
F
I
T
Y
G
K
Q
P
H
L
D
M
-----
K
Y
T
V
F
G
K
V
I
D
G
-
L
-
E
-----------------------
103
HHSearch
66.64
40%
-28
- C5 -
2X7K
3
PPIL1_HUMAN
A:
[12-146]
--
P
N
V
Y
L
E
T
S
M
G
I
I
V
L
E
L
Y
W
K
H
A
P
K
T
C
K
N
F
A
E
L
A
R
---------------
R
G
Y
--------
Y
N
G
T
K
F
H
R
I
I
K
D
F
M
I
Q
G
G
-
D
P
T
G
T
-
G
R
G
G
A
S
IY-------------------------
G
-
K
Q
F
E
D
E
L
H
P
D
L
K
F
T
-
G
--
A
-
G
I
--
L
A
M
A
N
A
-
G
---
P
D
T
N
G
S
Q
F
F
V
T
L
A
P
T
Q
W
L
D
G
-----
K
H
T
I
F
G
R
V
C
Q
--
G
I
G
M
V
N
R
V
-----
G
M
V
E
---------
107
HHSearch
65.81
38%
-17
- C5 -
1ZKC
1
PPIL2_HUMAN
A:
[20-154]
--
G
Y
V
R
L
H
T
N
K
G
D
L
N
L
E
L
H
C
D
L
T
P
K
T
C
E
N
F
I
R
L
C
K
---------------
K
H
Y
--------
Y
D
G
T
I
F
H
R
S
I
R
N
F
V
I
Q
G
G
-
D
P
T
G
T
-
G
T
G
G
E
S
YW-------------------------
G
-
K
P
F
K
D
E
F
R
P
N
L
S
H
T
-
G
--
R
-
G
I
--
L
S
M
A
N
S
-
G
---
P
N
S
N
R
S
Q
F
F
I
T
F
R
S
C
A
Y
L
D
K
-----
K
H
T
I
F
G
R
V
V
G
--
G
F
D
V
L
T
A
M
-----
E
N
V
E
---------
4
PsiBlast_PDB
65.11
48%
-33
- C5 -
2X7K
3
PPIL1_HUMAN
A:
[23-136]
-------------
I
V
L
E
L
Y
W
K
H
A
P
K
T
C
K
N
F
A
E
L
A
R
---------------
R
G
Y
--------
Y
N
G
T
K
F
H
R
I
I
K
D
F
M
I
Q
G
G
-
D
P
T
G
T
-
G
R
G
G
A
----------------------------
S
I
Y
G
K
Q
F
E
D
E
L
H
P
D
L
K
-
F
--
T
-
G
A
G
I
L
A
M
A
N
A
-
G
---
P
D
T
N
G
S
Q
F
F
V
T
L
A
P
T
Q
W
L
D
G
-----
K
H
T
I
F
G
R
V
C
Q
G
-
I
-------------------------
22
PsiBlast_CBE
65.02
44%
-9
- C5 -
2OJU
1
PPIL3_HUMAN
B:
[11-132]
------
L
H
T
D
V
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
L
A
L
C
A
---------------
S
N
Y
--------
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
-
D
P
T
G
T
-
G
R
G
G
N
----------------------------
S
I
W
G
K
K
F
E
D
E
Y
S
E
Y
L
K
-
H
NV
R
-
G
V
--
V
S
M
A
N
N
-
G
---
P
N
T
N
G
S
Q
F
F
I
T
Y
G
K
Q
P
H
L
D
M
-----
K
Y
T
V
F
G
K
V
I
D
G
-
L
-
E
-----------------------
10
PsiBlast_PDB
64.47
44%
-11
- C5 -
2OK3
1
PPIL3_HUMAN
A:
[5-126]
------
L
H
T
D
V
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
L
A
L
C
A
---------------
S
N
Y
--------
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
-
D
P
T
G
T
-
G
R
G
G
N
----------------------------
S
I
W
G
K
K
F
E
D
E
Y
S
E
Y
L
K
-
H
NV
R
-
G
V
--
V
S
M
A
N
N
-
G
---
P
N
T
N
G
S
Q
F
F
I
T
Y
G
K
Q
P
H
L
D
M
-----
K
Y
T
V
F
G
K
V
I
D
G
-
L
-
E
-----------------------
110
HHSearch
63.82
37%
-6
- C5 -
4R3F
11
?
A:
[16-176]
--
G
A
V
I
I
H
T
T
Q
G
D
L
K
V
E
L
F
A
K
Q
T
P
L
T
C
R
N
F
L
Q
H
S
L
---------------
D
G
Y
--------
Y
D
G
T
I
F
H
R
L
V
P
G
F
I
I
Q
G
G
-
D
P
T
G
T
-
G
H
G
G
E
S
IYDGGAFSGDLDPWPMDQRKGHNAGPM
G
-
V
N
F
K
D
E
F
H
S
R
L
K
F
N
-
R
--
R
-
G
L
--
L
G
M
A
N
E
-
G
A--
P
D
T
N
G
S
Q
F
F
F
T
L
G
K
A
E
E
L
N
N
-----
K
N
T
L
F
G
R
V
A
A
--
G
D
T
I
Y
N
L
M
-----
K
W
G
E
---------
11
PsiBlast_PDB
63.81
44%
-20
- C5 -
2HQ6
1
CWC27_HUMAN
A:
[36-146]
-------------
I
D
I
E
L
W
S
K
E
A
P
K
A
C
R
N
F
I
Q
L
C
L
---------------
E
A
Y
--------
Y
D
N
T
I
F
H
R
V
V
P
G
F
I
V
Q
G
G
-
D
P
T
G
T
-
G
S
G
G
E
S
IY-------------------------
G
-
A
P
F
K
D
E
F
H
S
R
L
R
F
N
-
R
--
R
-
G
L
--
V
A
M
A
N
A
-
G
---
S
H
D
N
G
S
Q
F
F
F
T
L
G
R
A
D
E
L
N
N
-----
K
H
T
I
F
G
K
V
T
-----------------------------
29
PsiBlast_CBE
63.80
45%
-6
- C5 -
4HY7
1
?
A:
[19-149]
------------
R
I
V
M
E
L
Y
K
D
A
V
P
R
T
V
E
N
F
R
A
L
C
T
GE-------------
K
G
V
GKSGKPLH
Y
K
G
S
A
F
H
R
V
I
P
D
F
M
C
Q
G
G
D
F
T
R
G
N
-
G
T
G
G
E
----------------------------
S
I
Y
G
E
K
F
A
D
E
K
F
V
H
K
H
T
K
--
P
-
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
V
P
C
N
W
L
D
G
-----
K
H
V
V
F
G
E
V
V
E
G
-
M
-
D
V
V
K
N
I
------------------
8
PsiBlast_PDB
63.58
44%
-9
- C5 -
2OJU
1
PPIL3_HUMAN
A:
[11-132]
------
L
H
T
D
V
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
L
A
L
C
A
---------------
S
N
Y
--------
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
-
D
P
T
G
T
-
G
R
G
G
N
----------------------------
S
I
W
G
K
K
F
E
D
E
Y
S
E
Y
L
K
-
H
NV
R
-
G
V
--
V
S
M
A
N
N
-
G
---
P
N
T
N
G
S
Q
F
F
I
T
Y
G
K
Q
P
H
L
D
M
-----
K
Y
T
V
F
G
K
V
I
D
G
-
L
-
E
-----------------------
88
PsiBlast_CBE
62.67
41%
38
- C5 -
1NMK
2
PPIA_HUMAN
B:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
7
PsiBlast_PDB
62.19
44%
-17
- C5 -
4R3E
3
CWC27_HUMAN
A:
[26-136]
-------------
I
D
I
E
L
W
S
K
E
A
P
K
A
C
R
N
F
I
Q
L
C
L
---------------
E
A
Y
--------
Y
D
N
T
I
F
H
R
V
V
P
G
F
I
V
Q
G
G
-
D
P
T
G
T
-
G
S
G
G
E
S
IY-------------------------
G
-
A
P
F
K
D
E
F
H
S
R
L
R
F
N
-
R
--
R
-
G
L
--
V
A
M
A
N
A
-
G
---
S
H
D
N
G
S
Q
F
F
F
T
L
G
R
A
D
E
L
N
N
-----
K
H
T
I
F
G
K
V
T
-----------------------------
89
PsiBlast_CBE
61.27
41%
39
- C5 -
1NMK
2
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
63
PsiBlast_CBE
61.19
41%
40
- C5 -
2RMB
3
PPIA_HUMAN
K:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
31
PsiBlast_CBE
61.17
41%
47
- C5 -
4N1S
2
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
82
PsiBlast_CBE
60.95
41%
39
- C5 -
1YND
2
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
37
PsiBlast_CBE
60.82
41%
46
- C5 -
4IPZ
3
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
-
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
98
PsiBlast_CBE
60.81
41%
44
* C5 *
1CWK
1
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
70
PsiBlast_CBE
60.79
41%
39
- C5 -
2RMA
3
PPIA_HUMAN
Q:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
60
PsiBlast_CBE
60.75
41%
42
- C5 -
2RMB
3
PPIA_HUMAN
Q:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
96
PsiBlast_CBE
60.71
41%
41
- C5 -
1CWM
1
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
25
PsiBlast_CBE
60.43
42%
43
- C5 -
4DGC
2
PPIA_MACMU
C:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
N
F
T
----
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
34
PsiBlast_CBE
60.34
41%
43
- C5 -
4N1P
3
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
93
PsiBlast_CBE
60.22
41%
41
- C5 -
1M63
1
PPIA_HUMAN
C:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
90
PsiBlast_CBE
60.19
41%
41
- C5 -
1MIK
1
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
81
PsiBlast_CBE
59.90
41%
42
- C5 -
1YND
2
PPIA_HUMAN
B:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
40
PsiBlast_CBE
59.87
41%
44
- C5 -
3ODL
3
PPIA_HUMAN
O:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
99
PsiBlast_CBE
59.78
41%
42
- C5 -
1CWJ
1
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
45
PsiBlast_CBE
59.65
41%
45
- C5 -
3ODL
3
PPIA_HUMAN
E:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
18
PsiBlast_PDB
59.64
42%
40
- C5 -
4DGC
1
PPIA_MACMU
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
N
F
T
H
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
80
PsiBlast_CBE
59.59
41%
47
- C5 -
1ZKF
2
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
72
PsiBlast_CBE
59.55
41%
46
- C5 -
2RMA
3
PPIA_HUMAN
M:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
77
PsiBlast_CBE
59.52
41%
44
- C5 -
2RMA
3
PPIA_HUMAN
C:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
35
PsiBlast_CBE
59.52
41%
44
- C5 -
4N1O
5
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
53
PsiBlast_CBE
59.51
41%
39
- C5 -
3ODI
3
PPIA_HUMAN
I:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
95
PsiBlast_CBE
59.50
41%
45
- C5 -
1CWO
1
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
66
PsiBlast_CBE
59.47
41%
42
- C5 -
2RMB
3
PPIA_HUMAN
E:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
57
PsiBlast_CBE
59.45
41%
45
- C5 -
3ODI
3
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
94
PsiBlast_CBE
59.41
41%
43
- C5 -
1FGL
1
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
36
PsiBlast_CBE
59.38
41%
46
- C5 -
4N1N
1
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
92
PsiBlast_CBE
59.34
41%
43
- C5 -
1M63
1
PPIA_HUMAN
G:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
46
PsiBlast_CBE
59.31
41%
42
- C5 -
3ODL
3
PPIA_HUMAN
C:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
68
PsiBlast_CBE
59.30
41%
43
- C5 -
2RMB
3
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
97
PsiBlast_CBE
59.29
41%
44
- C5 -
1CWL
1
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
71
PsiBlast_CBE
59.29
41%
40
- C5 -
2RMA
3
PPIA_HUMAN
O:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
39
PsiBlast_CBE
59.28
41%
46
- C5 -
3ODL
3
PPIA_HUMAN
Q:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
30
PsiBlast_CBE
59.28
41%
43
- C5 -
3RDD
1
PPIA_HUMAN
A:
[38-177]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
41
PsiBlast_CBE
59.25
41%
43
- C5 -
3ODL
3
PPIA_HUMAN
M:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
75
PsiBlast_CBE
59.22
41%
47
- C5 -
2RMA
3
PPIA_HUMAN
G:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
67
PsiBlast_CBE
59.22
41%
41
- C5 -
2RMB
3
PPIA_HUMAN
C:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
44
PsiBlast_CBE
59.14
41%
45
- C5 -
3ODL
3
PPIA_HUMAN
G:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
76
PsiBlast_CBE
59.12
41%
40
- C5 -
2RMA
3
PPIA_HUMAN
E:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
51
PsiBlast_CBE
59.12
41%
44
- C5 -
3ODI
3
PPIA_HUMAN
M:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
84
PsiBlast_CBE
59.08
41%
44
- C5 -
1W8L
1
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
78
PsiBlast_CBE
59.06
41%
44
- C5 -
2RMA
3
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
61
PsiBlast_CBE
59.05
41%
42
- C5 -
2RMB
3
PPIA_HUMAN
O:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
49
PsiBlast_CBE
59.04
41%
45
- C5 -
3ODI
3
PPIA_HUMAN
Q:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
50
PsiBlast_CBE
58.99
41%
44
- C5 -
3ODI
3
PPIA_HUMAN
O:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
33
PsiBlast_CBE
58.98
41%
44
- C5 -
4N1Q
1
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
73
PsiBlast_CBE
58.97
41%
42
- C5 -
2RMA
3
PPIA_HUMAN
K:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
91
PsiBlast_CBE
58.93
41%
45
- C5 -
1MF8
1
PPIA_HUMAN
C:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
12
PsiBlast_PDB
58.90
42%
37
- C5 -
4DGD
1
PPIA_MACMU
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
N
F
T
H
C
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
48
PsiBlast_CBE
58.86
41%
47
- C5 -
3ODI
3
PPIA_HUMAN
S:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
100
PsiBlast_CBE
58.85
41%
44
- C5 -
1CWI
1
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
32
PsiBlast_CBE
58.83
41%
48
- C5 -
4N1R
1
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
47
PsiBlast_CBE
58.75
41%
47
- C5 -
3ODL
3
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
42
PsiBlast_CBE
58.70
41%
42
- C5 -
3ODL
3
PPIA_HUMAN
K:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
54
PsiBlast_CBE
58.67
41%
45
- C5 -
3ODI
3
PPIA_HUMAN
G:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
17
PsiBlast_PDB
58.63
42%
40
- C5 -
4DGB
1
PPIA_MACMU
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
N
F
T
H
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
86
PsiBlast_CBE
58.52
41%
46
- C5 -
1VBT
2
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
RFGS
R
N
G
K
T
S
K
K
I
T
I
--
64
PsiBlast_CBE
58.51
41%
43
- C5 -
2RMB
3
PPIA_HUMAN
I:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
74
PsiBlast_CBE
58.47
41%
42
- C5 -
2RMA
3
PPIA_HUMAN
I:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
79
PsiBlast_CBE
58.45
41%
47
- C5 -
1ZKF
2
PPIA_HUMAN
B:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
FGS
R
N
G
K
T
S
K
K
I
T
I
--
55
PsiBlast_CBE
58.36
41%
42
- C5 -
3ODI
3
PPIA_HUMAN
E:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
65
PsiBlast_CBE
58.32
41%
45
- C5 -
2RMB
3
PPIA_HUMAN
G:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
83
PsiBlast_CBE
58.28
41%
46
- C5 -
1W8M
1
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
62
PsiBlast_CBE
58.21
41%
48
- C5 -
2RMB
3
PPIA_HUMAN
M:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
43
PsiBlast_CBE
58.19
41%
47
- C5 -
3ODL
3
PPIA_HUMAN
I:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
56
PsiBlast_CBE
58.14
41%
43
- C5 -
3ODI
3
PPIA_HUMAN
C:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
52
PsiBlast_CBE
58.13
41%
45
- C5 -
3ODI
3
PPIA_HUMAN
K:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
38
PsiBlast_CBE
58.12
41%
45
- C5 -
3ODL
3
PPIA_HUMAN
S:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
85
PsiBlast_CBE
58.03
41%
46
- C5 -
1VBT
2
PPIA_HUMAN
B:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
69
PsiBlast_CBE
57.96
41%
42
- C5 -
2RMA
3
PPIA_HUMAN
S:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
26
PsiBlast_CBE
57.94
42%
41
- C5 -
4DGC
1
PPIA_MACMU
B:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
N
F
T
------
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
20
PsiBlast_PDB
57.57
42%
32
- C5 -
1XQ7
1
?
A:
[21-145]
------------
R
V
V
I
G
L
F
G
N
D
V
P
K
T
V
E
N
F
K
Q
L
A
S
GE-------------
N
G
F
G-------
Y
K
G
S
I
F
H
R
V
I
R
N
F
M
I
Q
G
G
D
F
T
N
F
D
-
G
T
G
G
K
----------------------------
S
I
Y
G
T
R
F
D
D
E
N
L
K
I
K
H
-
F
--
V
-
G
A
--
V
S
M
A
N
A
-
G
---
P
N
S
N
G
S
Q
F
F
V
T
T
A
P
T
P
W
L
D
G
-----
R
H
V
V
F
G
K
V
V
E
G
-
M
-
D
V
V
K
K
V
-----
E
N
-----------
23
PsiBlast_CBE
57.48
42%
39
- C5 -
4DGC
2
PPIA_MACMU
E:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
N
F
T
------
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
27
PsiBlast_CBE
57.38
42%
27
- C5 -
1XQ7
1
?
C:
[21-145]
------------
R
V
V
I
G
L
F
G
N
D
V
P
K
T
V
E
N
F
K
Q
L
A
S
GE-------------
N
G
F
G-------
Y
K
G
S
I
F
H
R
V
I
R
N
F
M
I
Q
G
G
D
F
T
N
F
D
-
G
T
G
G
K
----------------------------
S
I
Y
G
T
R
F
D
D
E
N
L
K
I
K
H
-
F
--
V
-
G
A
--
V
S
M
A
N
A
-
G
---
P
N
S
N
G
S
Q
F
F
V
T
T
A
P
T
P
W
L
D
G
-----
R
H
V
V
F
G
K
V
V
E
G
-
M
-
D
V
V
K
K
V
-----
E
N
-----------
59
PsiBlast_CBE
57.31
41%
38
- C5 -
2RMB
3
PPIA_HUMAN
S:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
ERFGS
R
N
G
K
T
S
K
K
I
T
I
--
28
PsiBlast_CBE
56.83
42%
27
- C5 -
1XQ7
1
?
B:
[21-145]
------------
R
V
V
I
G
L
F
G
N
D
V
P
K
T
V
E
N
F
K
Q
L
A
S
GE-------------
N
G
F
G-------
Y
K
G
S
I
F
H
R
V
I
R
N
F
M
I
Q
G
G
D
F
T
N
F
D
-
G
T
G
G
K
----------------------------
S
I
Y
G
T
R
F
D
D
E
N
L
K
I
K
H
-
F
--
V
-
G
A
--
V
S
M
A
N
A
-
G
---
P
N
S
N
G
S
Q
F
F
V
T
T
A
P
T
P
W
L
D
G
-----
R
H
V
V
F
G
K
V
V
E
G
-
M
-
D
V
V
K
K
V
-----
E
N
-----------
87
PsiBlast_CBE
56.82
41%
52
- C5 -
1VBS
1
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
58
PsiBlast_CBE
56.42
41%
27
- C5 -
3CYS
1
PPIA_HUMAN
A:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
R
H
N
-
G
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--
24
PsiBlast_CBE
55.66
42%
38
- C5 -
4DGC
2
PPIA_MACMU
D:
[19-158]
------------
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
L
S
T
GE-------------
K
G
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
N
F
T
-----
T
G
G
K
----------------------------
S
I
Y
G
E
K
F
E
D
E
N
F
I
L
K
H
-
T
--
G
P
G
I
--
L
S
M
A
N
A
-
G
---
P
N
T
N
G
S
Q
F
F
I
C
T
A
K
T
E
W
L
D
G
-----
K
H
V
V
F
G
K
V
K
E
G
-
M
-
N
I
V
E
A
M
E
R
F
GS
R
N
G
K
T
S
K
K
I
T
I
--