@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu34790: (2016-07-29 )
MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQMANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKEYKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEEGVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVTLVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAAGDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK
Atome Classification :
(43 SA)
.........10........20........30..-.----......40----..-----.......50.....-.-.-.60.........70.....-----...80......-.-.--90----...---.---...-.100.......110.......120.......130.......140-........150.......160.......170.......180.......190---.......200....--...210--..---......220.......-230.......240--........250...-......260-.-----.-.-....270.......280.--.--.....290.......300...---....310....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSEE
K
I
Y
D
V
I
I
IGAGPAG
M
T
A
A
V
Y
TSRANL-
S
T
-
L
----
M
IERGIP-----GG-----QMA
N
T
E
D
VENYP
G
F
-
E
-
S
-IL-G
P
E
L
S
N
K
M
F
E
H
A
K
K
FG-----AEYAYG
D
I
K
E
V-I-D--GK----
E
Y
K
---
V
---
V
KA-GSKE
Y
K
A
R
A
V
I
I
AAGA
E
Y
K
KIGVPGEKELGGRG
V
S
Y
C
A
VCDGA--FFKG
K
E
L
V
V
VGGG
D
S
A
V
EE
G
V
Y
L
T
RFA
S
K
V
T
I
V
H
R
R
D
K
L
R
A
Q
S
I
L
Q
A
RAFD---NE
K
V
D
F
L
W
N
K
T
V
K
E
--
I
H
E
EN---GK---VG
N
V
T
L
V
D
TVTGEESE-FKTD
G
V
F
I
Y
I
GM---LPLSK
P
F
E
N--LGI-TNEE
G
Y
I
ET-N-----D-R-M
E
T
K
V
E
G
I
F
AAG
D
I
R
E
K
S
--
L
--
R
Q
I
V
TATGD
G
S
I
A
A
Q
S
V
Q
H
Y
V
---
E
E
L
Q
E
T
L
K
TLK
1
PsiBlast_PDB
95.93
70%
-100
- C3 -
4GCM
6
TRXB_STAAW
A:
[7-310]
------
F
D
I
A
I
I
G
A
G
P
A
G
M
T
A
A
V
Y
A
S
R
A
N
L
-
K
T
-
V
----
M
I
E
R
G
I
P
-----
G
G
-----
Q
M
A
N
T
E
E
V
E
N
F
P
G
F
-
E
-
M
-
I
T
-
G
P
D
L
S
T
K
M
F
E
H
A
K
K
F
G
-----
A
V
Y
Q
Y
G
D
I
K
S
V
-
E
-
D
--
K
G
----
E
Y
K
---
V
---
I
N
F
-
G
N
K
E
L
T
A
K
A
V
I
I
A
T
G
A
E
Y
K
K
I
G
V
P
G
E
Q
E
L
G
G
R
G
V
S
Y
C
A
V
C
D
G
A
--
F
F
K
N
K
R
L
F
V
I
G
G
G
D
S
A
V
E
E
G
T
F
L
T
K
F
A
D
K
V
T
I
V
H
R
R
D
E
L
R
A
Q
R
I
L
Q
D
R
A
F
K
---
N
D
K
I
D
F
I
W
S
H
T
L
K
S
--
I
N
E
K
D
---
G
K
---
V
G
S
V
T
L
T
S
T
K
D
G
S
E
E
T
-
H
E
A
D
G
V
F
I
Y
I
G
M
---
K
P
L
T
A
P
F
K
D
--
L
G
I
-
T
N
D
V
G
Y
I
V
T
-
K
-----
D
-
D
-
M
T
T
S
V
P
G
I
F
A
A
G
D
V
R
D
K
G
--
L
--
R
Q
I
V
T
A
T
G
D
G
S
I
A
A
Q
S
A
A
E
Y
I
---
E
H
L
N
D
------
69
HHSearch
93.32
71%
-68
- C3 -
4GCM
6
TRXB_STAAW
A:
[4-308]
---
E
I
D
F
D
I
A
I
I
G
A
G
P
A
G
M
T
A
A
V
Y
A
S
R
A
N
L
-
K
T
-
V
----
M
I
E
R
G
I
P
-----
G
G
-----
Q
M
A
N
T
E
E
V
E
N
F
P
G
F
-
E
-
M
-
I
T
-
G
P
D
L
S
T
K
M
F
E
H
A
K
K
F
G
-----
A
V
Y
Q
Y
G
D
I
K
S
V
-
E
-
D
--
K
G
----
E
Y
K
---
V
---
I
N
F
-
G
N
K
E
L
T
A
K
A
V
I
I
A
T
G
A
E
Y
K
K
I
G
V
P
G
E
Q
E
L
G
G
R
G
V
S
Y
C
A
V
C
D
G
A
--
F
F
K
N
K
R
L
F
V
I
G
G
G
D
S
A
V
E
E
G
T
F
L
T
K
F
A
D
K
V
T
I
V
H
R
R
D
E
L
R
A
Q
R
I
L
Q
D
R
A
F
K
---
N
D
K
I
D
F
I
W
S
H
T
L
K
S
--
I
N
E
K
D
---
G
K
---
V
G
S
V
T
L
T
S
T
K
D
G
S
E
E
T
-
H
E
A
D
G
V
F
I
Y
I
G
M
---
K
P
L
T
A
P
F
K
D
L-
G
I
T
--
N
D
V
G
Y
I
V
T
-
K
-----
D
-
D
-
M
T
T
S
V
P
G
I
F
A
A
G
D
V
R
D
K
G
--
L
--
R
Q
I
V
T
A
T
G
D
G
S
I
A
A
Q
S
A
A
E
Y
I
---
E
H
L
--------
48
PsiBlast_CBE
79.29
39%
-93
- C3 -
3F8P
4
?
B:
[16-318]
------
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
-
K
T
-
L
----
V
I
G
E
-
T
P
-----
G
G
-----
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
-
I
-
E
-
I
Q
-
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
-----
V
P
V
L
L
-
D
I
V
E
K
-
I
-
E
--------
E
F
V
---
V
---
K
T
K
-
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
E
--
I
K
G
D
K
----
V
---
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
-
L
N
V
N
G
V
F
I
E
I
G
F
---
D
P
P
T
D
F
A
K
S
--
N
G
I
E
T
D
T
N
G
Y
I
K
V
-
D
-----
E
-
W
-
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
--
L
GF
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
---
T
E
---------
3
PsiBlast_PDB
72.92
44%
-13
- C3 -
2A87
5
TRXB_MYCTU
A:
[10-321]
-
A
H
H
P
V
R
D
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
L
Y
A
A
R
A
Q
L
-
A
P
-
L
----
V
F
E
G
T
S
F
-----
G
G
-----
A
L
M
T
T
T
D
V
E
N
Y
P
G
F
-
R
-
N
G
I
T
-
G
P
E
L
M
D
E
M
R
E
Q
A
L
R
F
G
-----
A
D
L
R
M
E
D
V
E
S
V
S
L
-
H
--
G
P
----
L
K
S
---
V
---
V
T
A
-
D
G
Q
T
H
R
A
R
A
V
I
L
A
M
G
A
A
A
R
Y
L
Q
V
P
G
E
Q
E
L
L
G
R
G
V
S
S
C
A
T
C
D
G
F
--
F
F
R
D
Q
D
I
A
V
I
G
G
G
D
S
A
M
E
E
A
T
F
L
T
R
F
A
R
S
V
T
L
V
H
R
R
D
E
F
R
A
S
K
I
M
L
D
R
A
R
N
---
N
D
K
I
R
F
L
T
N
H
T
V
V
A
--
V
-
D
G
D
---
T
T
---
V
T
G
L
R
V
R
D
T
N
T
G
A
E
T
T
-
L
P
V
T
G
V
F
V
A
I
G
H
---
E
P
R
S
G
L
V
R
E
--
A
I
D
-
V
D
P
D
G
Y
V
L
V
-
Q
-----
G
-
R
T
T
S
T
S
L
P
G
V
F
A
A
G
D
L
V
D
R
T
--
Y
--
R
Q
A
V
T
A
A
G
S
G
C
A
A
A
I
D
A
E
R
W
L
---
A
E
H
A
A
T
-----
71
HHSearch
72.03
42%
-23
- C3 -
4JNQ
2
?
A:
[22-337]
-
M
T
Q
R
H
A
P
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
I
Y
A
A
R
A
M
L
-
K
P
-
V
----
V
I
A
G
L
Q
Q
-----
G
G
-----
Q
L
M
I
T
T
D
V
E
N
Y
P
G
Y
-
A
E
P
-
V
Q
-
G
P
W
M
M
E
Q
M
A
R
Q
A
E
N
V
G
-----
A
Q
I
V
H
D
I
I
T
E
V
E
T
-
T
--
V
R
----
P
F
R
---
L
---
K
G
D
-
S
G
T
I
Y
T
C
D
A
L
I
I
A
T
G
A
Q
A
K
W
L
G
L
E
S
E
Q
T
F
M
G
G
G
V
S
A
C
A
T
C
D
G
F
--
F
Y
R
G
K
D
V
V
V
V
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
H
I
A
K
S
V
T
I
V
H
R
R
D
G
F
R
A
E
K
I
M
Q
D
R
L
L
S
---
R
E
N
V
S
V
V
W
N
S
V
I
D
E
--
I
L
G
T
E
ARG
A
T
---
V
T
G
V
R
L
K
N
I
V
T
G
E
T
Q
E
-
R
A
T
H
G
V
F
I
A
I
G
H
---
A
P
A
V
S
L
F
E
G
--
K
L
K
-
Q
K
P
N
G
Y
L
W
T
-
A
-----
P
D
S
-
T
A
T
D
V
P
G
I
F
A
A
G
D
V
T
D
D
I
--
Y
--
R
Q
A
V
T
A
A
G
M
G
C
M
A
A
L
E
A
E
R
W
L
---
A
A
Q
--------
51
PsiBlast_CBE
71.88
39%
-35
- C3 -
3F8D
3
?
C:
[16-318]
------
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
-
K
T
-
L
----
V
I
G
E
-
T
P
-----
G
G
-----
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
-
I
-
E
-
I
Q
-
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
-----
V
P
V
L
L
-
D
I
V
E
K
-
I
-
E
N-------
E
F
V
---
V
---
K
T
K
-
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
A
D
A
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
E
--
I
K
G
D
K
----
V
---
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
-
L
N
V
N
G
V
F
I
E
I
G
F
---
D
P
P
T
D
F
A
K
S
--
N
G
I
E
T
D
T
N
G
Y
I
K
V
-
D
-----
E
-
W
-
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
--
L
GF
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
---
T
E
---------
77
HHSearch
71.60
45%
-14
- C3 -
2A87
5
TRXB_MYCTU
A:
[11-319]
--
H
H
P
V
R
D
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
L
Y
A
A
R
A
Q
L
-
A
P
-
L
----
V
F
E
G
T
S
F
-----
G
G
-----
A
L
M
T
T
T
D
V
E
N
Y
P
G
F
-
R
N
G
-
I
T
-
G
P
E
L
M
D
E
M
R
E
Q
A
L
R
F
G
-----
A
D
L
R
M
E
D
V
E
S
V
S
L
-
H
--
G
P
----
L
K
S
---
V
---
V
T
A
-
D
G
Q
T
H
R
A
R
A
V
I
L
A
M
G
A
A
A
R
Y
L
Q
V
P
G
E
Q
E
L
L
G
R
G
V
S
S
C
A
T
C
D
G
F
--
F
F
R
D
Q
D
I
A
V
I
G
G
G
D
S
A
M
E
E
A
T
F
L
T
R
F
A
R
S
V
T
L
V
H
R
R
D
E
F
R
A
S
K
I
M
L
D
R
A
R
N
---
N
D
K
I
R
F
L
T
N
H
T
V
V
A
--
V
D
G
D
T
----
T
---
V
T
G
L
R
V
R
D
T
N
T
G
A
E
T
T
-
L
P
V
T
G
V
F
V
A
I
G
H
---
E
P
R
S
G
L
V
R
E
--
A
I
D
-
V
D
P
D
G
Y
V
L
V
-
Q
-----
G
R
T
-
T
S
T
S
L
P
G
V
F
A
A
G
D
L
V
D
R
T
--
Y
--
R
Q
A
V
T
A
A
G
S
G
C
A
A
A
I
D
A
E
R
W
L
---
A
E
H
A
-------
49
PsiBlast_CBE
71.36
39%
-35
- C3 -
3F8P
4
?
A:
[16-318]
------
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
-
K
T
-
L
----
V
I
G
E
-
T
P
-----
G
G
-----
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
-
I
-
E
-
I
Q
-
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
-----
V
P
V
L
L
-
D
I
V
E
K
-
I
-
E
N-------
E
F
V
---
V
---
K
T
K
-
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
E
--
I
K
G
D
K
----
V
---
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
-
L
N
V
N
G
V
F
I
E
I
G
F
---
D
P
P
T
D
F
A
K
S
--
N
G
I
E
T
D
T
N
G
Y
I
K
V
-
D
-----
E
-
W
-
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
--
L
GF
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
---
T
E
---------
72
HHSearch
71.21
37%
-31
- C3 -
3F8D
3
?
A:
[11-319]
-
K
P
G
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
-
K
T
-
L
----
V
I
G
E
T
-
P
-----
G
G
-----
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
-
I
-
E
-
I
Q
-
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
-----
V
P
V
L
L
D
I
V
E
K
I
E
N
-
R
--------
E
F
V
---
V
---
K
T
K
-
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
A
D
A
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
E
--
I
K
G
D
K
----
V
---
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
-
L
N
V
N
G
V
F
I
E
I
G
F
---
D
P
P
T
D
F
A
K
S
N
-
G
I
E
-
T
D
T
N
G
Y
I
K
V
-
D
-----
E
-
W
-
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
LG
F
--
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
---
T
E
K
--------
47
PsiBlast_CBE
71.08
39%
-34
- C3 -
3F8P
1
?
C:
[16-318]
------
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
-
K
T
-
L
----
V
I
G
E
-
T
P
-----
G
G
-----
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
-
I
-
E
-
I
Q
-
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
-----
V
P
V
L
L
-
D
I
V
E
K
-
I
-
E
N
-------
E
F
V
---
V
---
K
T
K
-
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
E
--
I
K
G
D
K
----
V
---
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
-
L
N
V
N
G
V
F
I
E
I
G
F
---
D
P
P
T
D
F
A
K
S
--
N
G
I
E
T
D
T
N
G
Y
I
K
V
-
D
-----
E
-
W
-
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
--
L
GF
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
---
T
E
---------
6
PsiBlast_PDB
70.92
38%
-8
- C3 -
2Q0L
2
TRXB_HELPY
A:
[1-310]
-----
M
I
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
N
A
-
V
----
L
F
E
K
G
M
P
-----
G
G
-----
Q
I
T
G
S
S
E
I
E
N
Y
P
G
V
-
K
-
E
-
V
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
G
-----
L
K
H
E
M
T
A
V
Q
R
V
-
S
-
K
--
K
D
----
S
H
F
---
V
---
I
L
A
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
S
P
K
R
T
G
I
K
G
E
S
E
Y
W
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
I
T
L
E
H
A
K
N
---
N
D
K
I
E
F
L
T
P
Y
V
V
E
E
--
I
K
G
D
A
---
S
G
---
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
-
L
V
V
P
G
F
F
I
F
V
G
Y
D
V
N
N
A
V
L
K
Q
E
D
N
SM
L
C
K
-
C
D
E
Y
G
S
I
V
V
-
D
-----
F
-
S
-
M
K
T
N
V
Q
G
L
F
A
A
G
D
I
R
I
F
A
--
P
--
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
V
I
S
Y
L
---
E
H
---------
43
PsiBlast_CBE
70.69
39%
-34
- C3 -
3F8R
3
?
C:
[16-318]
------
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
-
K
T
-
L
----
V
I
G
E
-
T
P
-----
G
G
-----
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
-
I
-
E
-
I
Q
-
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
-----
V
P
V
L
L
-
D
I
V
E
K
-
I
-
E
N-------
E
F
V
---
V
---
K
T
K
-
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
E
--
I
K
G
D
K
----
V
---
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
-
L
N
V
N
G
V
F
I
E
I
G
F
---
D
P
P
T
D
F
A
K
S
--
N
G
I
E
T
D
T
N
G
Y
I
K
V
-
D
-----
E
-
W
-
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
--
L
GF
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
---
T
E
---------
8
PsiBlast_PDB
70.52
42%
-23
- C3 -
4JNQ
2
?
A:
[29-338]
--------
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
I
Y
A
A
R
A
M
L
-
K
P
-
V
----
V
I
A
G
L
Q
Q
-----
G
G
-----
Q
L
M
I
T
T
D
V
E
N
Y
P
G
Y
A
E
-
P
-
V
Q
-
G
P
W
M
M
E
Q
M
A
R
Q
A
E
N
V
G
-----
A
Q
I
V
H
D
I
I
T
E
V
E
T
-
T
--
V
R
----
P
F
R
---
L
---
K
G
D
-
S
G
T
I
Y
T
C
D
A
L
I
I
A
T
G
A
Q
A
K
W
L
G
L
E
S
E
Q
T
F
M
G
G
G
V
S
A
C
A
T
C
D
G
F
--
F
Y
R
G
K
D
V
V
V
V
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
H
I
A
K
S
V
T
I
V
H
R
R
D
G
F
R
A
E
K
I
M
Q
D
R
L
L
S
---
R
E
N
V
S
V
V
W
N
S
V
I
D
E
--
I
L
G
T
E
---
A
R
GAT
V
T
G
V
R
L
K
N
I
V
T
G
E
T
Q
E
-
R
A
T
H
G
V
F
I
A
I
G
H
---
A
P
A
V
S
L
F
E
G
--
K
L
K
-
Q
K
P
N
G
Y
L
W
T
A
P
-----
D
-
S
-
T
A
T
D
V
P
G
I
F
A
A
G
D
V
T
D
D
I
--
Y
--
R
Q
A
V
T
A
A
G
M
G
C
M
A
A
L
E
A
E
R
W
L
A
A
Q
E
----------
78
HHSearch
70.51
48%
15
- C3 -
2Q7V
2
?
A:
[5-314]
--
T
A
H
D
Y
D
V
V
I
I
G
G
G
P
A
G
L
T
A
A
I
Y
T
G
R
A
Q
L
-
S
T
-
L
----
I
L
E
K
G
M
P
-----
G
G
-----
Q
I
A
W
S
E
E
V
E
N
F
P
G
F
-
P
E
P
-
I
A
-
G
M
E
L
A
Q
R
M
H
Q
Q
A
E
K
F
G
-----
A
K
V
E
M
D
E
V
Q
G
V
Q
H
-
D
--
A
T
SHPY
P
F
T
---
V
---
R
G
--
Y
N
G
E
Y
R
A
K
A
V
I
L
A
T
G
A
D
P
R
K
L
G
I
P
G
E
D
N
F
W
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
G
K
K
V
V
V
I
G
G
G
D
A
A
V
E
E
G
M
F
L
T
K
F
A
D
E
V
T
V
I
H
R
R
D
T
L
R
A
N
K
V
A
Q
A
R
A
F
A
---
N
P
K
M
K
F
I
W
D
T
A
V
E
E
--
I
Q
G
A
----
D
S
---
V
S
G
V
K
L
R
N
L
K
T
G
E
V
S
E
-
L
A
T
D
G
V
F
I
F
I
G
H
---
V
P
N
T
A
F
V
K
D
--
T
V
S
-
L
R
D
D
G
Y
V
D
V
-
R
-----
D
-
E
-
I
Y
T
N
I
P
M
L
F
A
A
G
D
V
S
D
Y
I
--
Y
--
R
Q
L
A
T
S
V
G
A
G
T
R
A
A
M
M
T
E
R
Q
L
---
A
A
L
--------
22
PsiBlast_CBE
69.87
44%
-13
- C3 -
2A87
5
TRXB_MYCTU
B:
[15-318]
------
R
D
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
L
Y
A
A
R
A
Q
L
-
A
P
-
L
----
V
F
E
G
T
S
F
-----
G
G
-----
A
L
M
T
T
T
D
V
E
N
Y
P
G
F
-
R
-
N
G
I
T
-
G
P
E
L
M
D
E
M
R
E
Q
A
L
R
F
G
-----
A
D
L
R
M
E
D
V
E
S
V
S
L
-
H
--
G
P
----
L
K
S
---
V
---
V
T
A
-
D
G
Q
T
H
R
A
R
A
V
I
L
A
M
G
A
A
A
R
Y
L
Q
V
P
G
E
Q
E
L
L
G
R
G
V
S
S
C
A
T
C
D
G
F
--
F
F
R
D
Q
D
I
A
V
I
G
G
G
D
S
A
M
E
E
A
T
F
L
T
R
F
A
R
S
V
T
L
V
H
R
R
D
E
F
R
A
S
K
I
M
L
D
R
A
R
N
---
N
D
K
I
R
F
L
T
N
H
T
V
V
A
--
V
-
D
G
D
---
T
T
---
V
T
G
L
R
V
R
D
T
N
T
G
A
E
T
T
-
L
P
V
T
G
V
F
V
A
I
G
H
---
E
P
R
S
G
L
V
R
E
--
A
I
D
-
V
D
P
D
G
Y
V
L
V
-
Q
-----
G
-
R
T
T
S
T
S
L
P
G
V
F
A
A
G
D
L
V
D
R
T
--
Y
--
R
Q
A
V
T
A
A
G
S
G
C
A
A
A
I
D
A
E
R
W
L
---
A
E
H
--------
21
PsiBlast_CBE
69.48
47%
8
- C3 -
2Q7V
2
?
B:
[9-314]
------
Y
D
V
V
I
I
G
G
G
P
A
G
L
T
A
A
I
Y
T
G
R
A
Q
L
-
S
T
-
L
----
I
L
E
K
G
M
P
-----
G
G
-----
Q
I
A
W
S
E
E
V
E
N
F
P
G
F
P
E
-
P
-
I
A
-
G
M
E
L
A
Q
R
M
H
Q
Q
A
E
K
F
G
-----
A
K
V
E
M
D
E
V
Q
G
V
-
Q
H
D
--
A
T
----
S
H
P
YP
F
T
---
V
R
G
-
Y
N
G
E
Y
R
A
K
A
V
I
L
A
T
G
A
D
P
R
K
L
G
I
P
G
E
D
N
F
W
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
G
K
K
V
V
V
I
G
G
G
D
A
A
V
E
E
G
M
F
L
T
K
F
A
D
E
V
T
V
I
H
R
R
D
T
L
R
A
N
K
V
A
Q
A
R
A
F
A
---
N
P
K
M
K
F
I
W
D
T
A
V
E
E
--
I
Q
G
A
D
----
S
---
V
S
G
V
K
L
R
N
L
K
T
G
E
V
S
E
-
L
A
T
D
G
V
F
I
F
I
G
H
---
V
P
N
T
A
F
V
K
D
--
T
V
S
-
L
R
D
D
G
Y
V
D
V
-
R
-----
D
-
E
-
I
Y
T
N
I
P
M
L
F
A
A
G
D
V
S
D
Y
I
--
Y
--
R
Q
L
A
T
S
V
G
A
G
T
R
A
A
M
M
T
E
R
Q
L
---
A
A
L
--------
46
PsiBlast_CBE
69.25
39%
-15
- C3 -
3F8P
2
?
D:
[16-318]
------
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
-
K
T
-
L
----
V
I
G
E
-
T
P
-----
G
G
-----
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
-
I
-
E
-
I
Q
-
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
-----
V
P
V
L
L
-
D
I
V
E
K
-
I
-
E
NR
G
D
----
E
F
V
---
V
---
K
T
K
-
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
E
--
I
K
G
D
K
----
V
---
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
-
L
N
V
N
G
V
F
I
E
I
G
F
---
D
P
P
T
D
F
A
K
S
--
N
G
I
E
T
D
T
N
G
Y
I
K
V
-
D
-----
E
-
W
-
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
--
L
GF
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
---
T
E
---------
25
PsiBlast_CBE
69.09
38%
-8
- C3 -
2Q0L
2
TRXB_HELPY
B:
[1-310]
-----
M
I
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
N
A
-
V
----
L
F
E
K
G
M
P
-----
G
G
-----
Q
I
T
G
S
S
E
I
E
N
Y
P
G
V
-
K
-
E
-
V
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
G
-----
L
K
H
E
M
T
A
V
Q
R
V
-
S
-
K
--
K
D
----
S
H
F
---
V
---
I
L
A
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
S
P
K
R
T
G
I
K
G
E
S
E
Y
W
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
I
T
L
E
H
A
K
N
---
N
D
K
I
E
F
L
T
P
Y
V
V
E
E
--
I
K
G
D
A
---
S
G
---
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
-
L
V
V
P
G
F
F
I
F
V
G
Y
DVN
N
A
V
L
K
Q
E
D
N
SM
L
C
K
-
C
D
E
Y
G
S
I
V
V
-
D
-----
F
-
S
-
M
K
T
N
V
Q
G
L
F
A
A
G
D
I
R
I
F
A
--
P
--
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
V
I
S
Y
L
---
E
H
---------
5
PsiBlast_PDB
69.01
38%
-8
- C3 -
2Q0K
3
TRXB_HELPY
A:
[1-310]
-----
M
I
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
N
A
-
V
----
L
F
E
K
G
M
P
-----
G
G
-----
Q
I
T
G
S
S
E
I
E
N
Y
P
G
V
-
K
-
E
-
V
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
G
-----
L
K
H
E
M
T
A
V
Q
R
V
-
S
-
K
--
K
D
----
S
H
F
---
V
---
I
L
A
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
S
P
K
R
T
G
I
K
G
E
S
E
Y
W
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
I
T
L
E
H
A
K
N
---
N
D
K
I
E
F
L
T
P
Y
V
V
E
E
--
I
K
G
D
A
---
S
G
---
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
-
L
V
V
P
G
F
F
I
F
V
G
Y
D
V
N
N
A
V
L
K
Q
E
D
N
SM
L
C
K
-
C
D
E
Y
G
S
I
V
V
-
D
-----
F
-
S
-
M
K
T
N
V
Q
G
L
F
A
A
G
D
I
R
I
F
A
--
P
--
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
V
I
S
Y
L
---
E
H
---------
24
PsiBlast_CBE
68.99
38%
-9
- C3 -
3ISH
2
TRXB_HELPY
B:
[1-310]
-----
M
I
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
N
A
-
V
----
L
F
E
K
G
M
P
-----
G
G
-----
Q
I
T
G
S
S
E
I
E
N
Y
P
G
V
-
K
-
E
-
V
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
G
-----
L
K
H
E
M
T
A
V
Q
R
V
-
S
-
K
--
K
D
----
S
H
F
---
V
---
I
L
A
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
S
P
K
R
T
G
I
K
G
E
S
E
Y
W
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
I
T
L
E
H
A
K
N
---
N
D
K
I
E
F
L
T
P
Y
V
V
E
E
--
I
K
G
D
A
---
S
G
---
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
-
L
V
V
P
G
F
F
I
F
V
G
Y
DVN
N
A
V
L
K
Q
E
D
N
SM
L
C
K
-
C
D
E
Y
G
S
I
V
V
-
D
-----
F
-
S
-
M
K
T
N
V
Q
G
L
F
A
A
G
D
I
R
I
F
A
--
P
--
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
V
I
S
Y
L
---
E
H
---------
45
PsiBlast_CBE
68.59
39%
-14
- C3 -
3F8R
3
?
A:
[16-318]
------
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
-
K
T
-
L
----
V
I
G
E
-
T
P
-----
G
G
-----
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
-
I
-
E
-
I
Q
-
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
-----
V
P
V
L
L
-
D
I
V
E
K
-
I
-
E
NR------
E
F
V
---
V
---
K
T
K
-
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
E
--
I
K
G
D
K
----
V
---
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
-
L
N
V
N
G
V
F
I
E
I
G
F
---
D
P
P
T
D
F
A
K
S
--
N
G
I
E
T
D
T
N
G
Y
I
K
V
-
D
-----
E
-
W
-
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
--
L
GF
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
---
T
E
---------
44
PsiBlast_CBE
67.23
39%
-12
- C3 -
3F8R
3
?
B:
[16-318]
------
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
-
K
T
-
L
----
V
I
G
E
-
T
P
-----
G
G
-----
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
-
I
-
E
-
I
Q
-
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
-----
V
P
V
L
L
-
D
I
V
E
K
-
I
-
E
N
R-
D
----
E
F
V
---
V
---
K
T
K
-
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
E
--
I
K
G
D
K
----
V
---
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
-
L
N
V
N
G
V
F
I
E
I
G
F
---
D
P
P
T
D
F
A
K
S
--
N
G
I
E
T
D
T
N
G
Y
I
K
V
-
D
-----
E
-
W
-
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
--
L
GF
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
---
T
E
---------
52
PsiBlast_CBE
64.81
39%
-11
- C3 -
3F8D
5
?
B:
[16-318]
------
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
-
K
T
-
L
----
V
I
G
E
-
T
P
-----
G
G
-----
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
-
I
-
E
-
I
Q
-
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
-----
V
P
V
L
L
-
D
I
V
E
K
-
I
-
E
N
R-
D
----
E
F
V
---
V
---
K
T
K
-
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
A
D
A
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
E
--
I
K
G
D
K
----
V
---
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
-
L
N
V
N
G
V
F
I
E
I
G
F
---
D
P
P
T
D
F
A
K
S
--
N
G
I
E
T
D
T
N
G
Y
I
K
V
-
D
-----
E
-
W
-
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
--
L
GF
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
---
T
E
---------
42
PsiBlast_CBE
64.61
39%
-17
- C3 -
3F8R
3
?
D:
[16-318]
------
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
-
K
T
-
L
----
V
I
G
E
-
T
P
-----
G
G
-----
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
-
I
-
E
-
I
Q
-
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
-----
V
P
V
L
L
-
D
I
V
E
K
-
I
-
E
N
R
G
D
----
E
F
V
---
V
---
K
T
K
-
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
E
--
I
K
G
D
K
----
V
---
V
K
Q
V
V
V
E
N
L
K
---------
V
N
G
V
F
I
E
I
G
F
---
D
P
P
T
D
F
A
K
S
--
N
G
I
E
T
D
T
N
G
Y
I
K
V
-
D
-----
E
-
W
-
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
--
L
GF
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
---
T
E
---------
20
PsiBlast_PDB
64.22
38%
-18
- C3 -
1TDF
2
TRXB_ECOLI
A:
[8-316]
--------
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
-
Q
P
-
V
----
L
I
T
G
M
E
K
-----
G
G
-----
Q
L
T
T
T
T
E
V
E
N
W
P
G
D
-
P
-
N
-
D
L
T
G
P
L
L
M
E
R
M
H
E
H
A
T
K
F
E
-----
T
E
I
I
F
D
H
I
N
K
V
D
L
-
Q
--
N
R
----
P
F
R
---
L
----
N
G
-
D
N
G
E
Y
T
C
D
A
L
I
I
A
T
G
A
S
A
R
Y
L
G
L
P
S
E
E
A
F
K
G
R
G
V
S
A
C
A
T
S
D
G
F
--
F
Y
R
N
Q
K
V
A
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
S
E
V
H
L
I
H
R
R
D
G
F
R
A
E
K
I
L
I
K
R
L
M
D
K
V
E
N
G
N
I
I
L
H
T
N
R
T
L
E
E
--
V
T
G
D
Q
---
M
G
---
V
T
G
V
R
L
R
D
T
Q
N
S
D
N
I
E
S
L
D
V
A
G
L
F
V
A
I
G
H
---
S
P
N
T
A
I
F
E
G
--
Q
-
L
-
E
L
E
N
G
Y
I
K
V
-
Q
SGIHG
N
-
A
-
T
Q
T
S
I
P
G
V
F
A
A
G
D
V
M
D
H
I
--
Y
--
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
---
D
G
L
--------
54
PsiBlast_CBE
62.70
38%
26
- C3 -
2WHD
3
?
B:
[33-343]
--------
V
C
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
A
A
R
A
E
L
-
K
P
-
V
----
L
F
E
G
W
M
A
NDIAA
G
G
-----
Q
L
T
T
T
T
D
V
E
N
F
P
G
F
-
P
-
T
G
I
M
-
G
I
D
L
M
D
N
C
R
A
Q
S
V
R
F
G
-----
T
N
I
L
S
E
T
V
T
E
V
D
F
-
S
--
A
R
----
P
F
R
---
V
---
T
-
S
-
D
S
T
T
V
L
A
D
T
V
V
V
A
T
G
A
V
A
R
R
L
Y
F
S
G
S
D
T
Y
W
N
R
G
I
S
A
C
A
V
C
D
G
A
AP
I
F
R
N
K
P
I
A
V
I
G
G
G
D
S
A
M
E
E
G
N
F
L
T
K
Y
G
S
Q
V
Y
I
I
H
R
R
N
T
F
R
A
S
K
I
M
Q
A
R
A
L
S
---
N
P
K
I
Q
V
V
W
D
S
E
V
V
E
A
Y
G
G
A
G
G
---
G
P
---
L
A
G
V
K
V
K
N
L
V
T
G
E
V
S
D
-
L
Q
V
S
G
L
F
F
A
I
G
H
---
E
P
A
T
K
F
L
N
G
--
Q
L
E
-
L
H
A
D
G
Y
V
A
T
-
K
-----
P
G
S
-
T
H
T
S
V
E
G
V
F
A
A
G
D
V
Q
D
K
K
--
Y
--
R
Q
A
I
T
A
A
G
S
G
C
M
A
A
L
D
A
E
H
Y
L
---
Q
E
V
--------
55
PsiBlast_CBE
62.02
38%
26
- C3 -
2WHD
3
?
A:
[33-343]
--------
V
C
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
A
A
R
A
E
L
-
K
P
-
V
----
L
F
E
G
W
M
A
NDIAA
G
G
-----
Q
L
T
T
T
T
D
V
E
N
F
P
G
F
-
P
-
T
G
I
M
-
G
I
D
L
M
D
N
C
R
A
Q
S
V
R
F
G
-----
T
N
I
L
S
E
T
V
T
E
V
D
F
-
S
--
A
R
----
P
F
R
---
V
---
T
-
S
-
D
S
T
T
V
L
A
D
T
V
V
V
A
T
G
A
V
A
R
R
L
Y
F
S
G
S
D
T
Y
W
N
R
G
I
S
A
C
A
V
C
D
G
A
AP
I
F
R
N
K
P
I
A
V
I
G
G
G
D
S
A
M
E
E
G
N
F
L
T
K
Y
G
S
Q
V
Y
I
I
H
R
R
N
T
F
R
A
S
K
I
M
Q
A
R
A
L
S
---
N
P
K
I
Q
V
V
W
D
S
E
V
V
E
A
Y
G
G
A
G
G
---
G
P
---
L
A
G
V
K
V
K
N
L
V
T
G
E
V
S
D
-
L
Q
V
S
G
L
F
F
A
I
G
H
---
E
P
A
T
K
F
L
N
G
--
Q
L
E
-
L
H
A
D
G
Y
V
A
T
-
K
-----
P
G
S
-
T
H
T
S
V
E
G
V
F
A
A
G
D
V
Q
D
K
K
--
Y
--
R
Q
A
I
T
A
A
G
S
G
C
M
A
A
L
D
A
E
H
Y
L
---
Q
E
V
--------
32
PsiBlast_CBE
61.27
37%
32
- C3 -
4CBQ
8
?
B:
[3-312]
----
N
I
H
D
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
-
K
P
-
V
----
M
Y
E
G
F
M
A
-----
G
G
VAAGG
Q
L
T
T
T
T
I
I
E
N
F
P
G
F
-
P
-
N
G
I
D
-
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
-----
T
T
I
I
T
E
T
I
D
H
V
D
F
-
S
--
T
Q
----
P
F
K
---
L
---
F
T
E
-
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
Y
W
Q
N
G
V
S
A
C
A
I
C
D
G
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
E
--
L
E
G
D
G
---
D
L
---
L
N
G
A
K
I
H
N
L
V
S
G
E
Y
K
V
-
V
P
V
A
G
L
F
Y
A
I
G
H
---
S
P
N
S
K
F
L
G
G
--
Q
V
K
-
T
A
D
D
G
Y
I
L
T
-------
E
-
G
-
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
--
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
---
Q
----------
34
PsiBlast_CBE
60.44
37%
36
- C3 -
4A5L
3
?
B:
[3-312]
----
N
I
H
D
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
-
K
P
-
V
----
M
Y
E
G
F
M
A
-----
G
G
VAAGG
Q
L
T
T
T
T
I
I
E
N
F
P
G
F
-
P
-
N
G
I
D
-
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
-----
T
T
I
I
T
E
T
I
D
H
V
D
F
-
S
--
T
Q
----
P
F
K
---
L
---
F
T
E
-
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
Y
W
Q
N
G
V
S
A
C
A
I
C
D
G
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
E
--
L
E
G
D
G
---
D
L
---
L
N
G
A
K
I
H
N
L
V
S
G
E
Y
K
V
-
V
P
V
A
G
L
F
Y
A
I
G
H
---
S
P
N
S
K
F
L
G
G
--
Q
V
K
-
T
A
D
D
G
Y
I
L
T
-------
E
-
G
-
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
--
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
---
Q
----------
64
PsiBlast_CBE
60.04
33%
30
- C3 -
4YKG
18
AHPF_ECOLI
A:
[207-515]
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
-
R
T
G
L
----
M
G
E
R
F
-------
G
G
-----
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
-
P
-
K
-
T
E
-
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
VDVID
S
Q
S
A
S
K
L
I
P
A
A
-
V
-
E
--
G
G
----
L
H
Q
---
I
---
E
T
A
-
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
P
H
-
C
D
G
P
--
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
L
R
S
---
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
--
V
K
G
D
G
---
S
K
---
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
-
I
E
L
A
G
I
F
V
Q
I
G
L
---
L
P
N
T
N
W
L
E
G
--
A
V
E
-
R
N
R
M
G
E
I
I
I
-
D
-----
A
-
K
-
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
P
--
Y
--
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
--------------
33
PsiBlast_CBE
59.86
37%
35
- C3 -
4A65
6
?
B:
[2-312]
---
S
N
I
H
D
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
-
K
P
-
V
----
M
Y
E
G
F
M
A
-----
G
G
VAAGG
Q
L
T
T
T
T
I
I
E
N
F
P
G
F
-
P
-
N
G
I
D
-
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
-----
T
T
I
I
T
E
T
I
D
H
V
D
F
-
S
--
T
Q
----
P
F
K
---
L
---
F
T
E
-
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
Y
W
Q
N
G
V
S
A
C
A
I
C
D
G
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
E
--
L
E
G
D
G
---
D
L
---
L
N
G
A
K
I
H
N
L
V
S
G
E
Y
K
V
-
V
P
V
A
G
L
F
Y
A
I
G
H
---
S
P
N
S
K
F
L
G
G
--
Q
V
K
-
T
A
D
D
G
Y
I
L
T
-------
E
-
G
-
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
--
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
---
Q
----------
31
PsiBlast_CBE
59.53
37%
30
- C3 -
4CCQ
5
?
B:
[3-312]
----
N
I
H
D
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
-
K
P
-
V
----
M
Y
E
G
F
M
A
-----
G
G
VAAGG
Q
L
T
T
T
T
I
I
E
N
F
P
G
F
-
P
-
N
G
I
D
-
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
-----
T
T
I
I
T
E
T
I
D
H
V
D
F
-
S
--
T
Q
----
P
F
K
---
L
---
F
T
E
-
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
Y
W
Q
N
G
V
S
A
C
A
I
C
D
G
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
E
--
L
E
G
D
G
---
D
L
---
L
N
G
A
K
I
H
N
L
V
S
G
E
Y
K
V
-
V
P
V
A
G
L
F
Y
A
I
G
H
---
S
P
N
S
K
F
L
G
G
--
Q
V
K
-
T
A
D
D
G
Y
I
L
T
-------
E
-
G
-
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
--
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
---
Q
----------
40
PsiBlast_CBE
59.03
37%
33
- C3 -
4UP3
4
?
B:
[3-312]
----
N
I
H
D
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
-
K
P
-
V
----
M
Y
E
G
F
M
A
-----
G
G
VAAGG
Q
L
T
T
T
T
I
I
E
N
F
P
G
F
-
P
-
N
G
I
D
-
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
-----
T
T
I
I
T
E
T
I
D
H
V
D
F
-
S
--
T
Q
----
P
F
K
---
L
---
F
T
E
-
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
Y
W
Q
N
G
V
S
A
S
A
I
C
D
G
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
E
--
L
E
G
D
G
---
D
L
---
L
N
G
A
K
I
H
N
L
V
S
G
E
Y
K
V
-
V
P
V
A
G
L
F
Y
A
I
G
H
---
S
P
N
S
K
F
L
G
G
--
Q
V
K
-
T
A
D
D
G
Y
I
L
T
-------
E
-
G
-
P
K
T
S
V
D
G
V
F
A
C
G
D
V
Q
D
R
V
--
Y
--
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
---
Q
----------
13
PsiBlast_PDB
58.88
37%
32
- C3 -
4A65
4
?
A:
[4-312]
-----
I
H
D
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
-
K
P
-
V
----
M
Y
E
G
F
M
A
-----
G
G
VAAGG
Q
L
T
T
T
T
I
I
E
N
F
P
G
F
-
P
-
N
G
I
D
-
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
-----
T
T
I
I
T
E
T
I
D
H
V
D
F
-
S
--
T
Q
----
P
F
K
---
L
---
F
T
E
-
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
Y
W
Q
N
G
V
S
A
C
A
I
C
D
G
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
E
--
L
E
G
D
G
---
D
L
---
L
N
G
A
K
I
H
N
L
V
S
G
E
Y
K
V
-
V
P
V
A
G
L
F
Y
A
I
G
H
---
S
P
N
S
K
F
L
G
G
--
Q
V
K
-
T
A
D
D
G
Y
I
L
T
-------
E
-
G
-
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
--
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
---
Q
----------
14
PsiBlast_PDB
58.66
37%
28
- C3 -
4CBQ
9
?
A:
[3-312]
----
N
I
H
D
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
-
K
P
-
V
----
M
Y
E
G
F
M
A
-----
G
G
VAAGG
Q
L
T
T
T
T
I
I
E
N
F
P
G
F
-
P
-
N
G
I
D
-
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
-----
T
T
I
I
T
E
T
I
D
H
V
D
F
-
S
--
T
Q
----
P
F
K
---
L
---
F
T
E
-
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
Y
W
Q
N
G
V
S
A
C
A
I
C
D
G
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
E
--
L
E
G
D
G
---
D
L
---
L
N
G
A
K
I
H
N
L
V
S
G
E
Y
K
V
-
V
P
V
A
G
L
F
Y
A
I
G
H
---
S
P
N
S
K
F
L
G
G
--
Q
V
K
-
T
A
D
D
G
Y
I
L
T
-------
E
-
G
-
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
--
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
---
Q
----------
41
PsiBlast_CBE
58.58
37%
31
- C3 -
4UP3
4
?
A:
[3-312]
----
N
I
H
D
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
-
K
P
-
V
----
M
Y
E
G
F
M
A
-----
G
G
VAAGG
Q
L
T
T
T
T
I
I
E
N
F
P
G
F
-
P
-
N
G
I
D
-
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
-----
T
T
I
I
T
E
T
I
D
H
V
D
F
-
S
--
T
Q
----
P
F
K
---
L
---
F
T
E
-
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
Y
W
Q
N
G
V
S
A
S
A
I
C
D
G
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
E
--
L
E
G
D
G
---
D
L
---
L
N
G
A
K
I
H
N
L
V
S
G
E
Y
K
V
-
V
P
V
A
G
L
F
Y
A
I
G
H
---
S
P
N
S
K
F
L
G
G
--
Q
V
K
-
T
A
D
D
G
Y
I
L
T
-------
E
-
G
-
P
K
T
S
V
D
G
V
F
A
C
G
D
V
Q
D
R
V
--
Y
--
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
---
Q
----------
12
PsiBlast_PDB
58.36
37%
28
- C3 -
4A5L
4
?
A:
[2-312]
---
S
N
I
H
D
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
-
K
P
-
V
----
M
Y
E
G
F
M
A
-----
G
G
VAAGG
Q
L
T
T
T
T
I
I
E
N
F
P
G
F
-
P
-
N
G
I
D
-
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
-----
T
T
I
I
T
E
T
I
D
H
V
D
F
-
S
--
T
Q
----
P
F
K
---
L
---
F
T
E
-
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
Y
W
Q
N
G
V
S
A
C
A
I
C
D
G
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
E
--
L
E
G
D
G
---
D
L
---
L
N
G
A
K
I
H
N
L
V
S
G
E
Y
K
V
-
V
P
V
A
G
L
F
Y
A
I
G
H
---
S
P
N
S
K
F
L
G
G
--
Q
V
K
-
T
A
D
D
G
Y
I
L
T
-------
E
-
G
-
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
--
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
---
Q
----------
15
PsiBlast_PDB
57.85
37%
31
- C3 -
4CCQ
6
?
A:
[2-312]
---
S
N
I
H
D
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
-
K
P
-
V
----
M
Y
E
G
F
M
A
-----
G
G
VAAGG
Q
L
T
T
T
T
I
I
E
N
F
P
G
F
-
P
-
N
G
I
D
-
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
-----
T
T
I
I
T
E
T
I
D
H
V
D
F
-
S
--
T
Q
----
P
F
K
---
L
---
F
T
E
-
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
Y
W
Q
N
G
V
S
A
C
A
I
C
D
G
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
E
--
L
E
G
D
G
---
D
L
---
L
N
G
A
K
I
H
N
L
V
S
G
E
Y
K
V
-
V
P
V
A
G
L
F
Y
A
I
G
H
---
S
P
N
S
K
F
L
G
G
--
Q
V
K
-
T
A
D
D
G
Y
I
L
T
-------
E
-
G
-
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
--
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
---
Q
----------
19
PsiBlast_PDB
56.57
37%
47
- C3 -
3ITJ
3
TRXB1_YEAST
A:
[25-337]
--------
V
T
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
A
R
A
E
I
-
K
P
-
I
L
Y
EG
M
M
A
N
G
I
A
A----
G
G
-----
Q
L
T
T
T
T
E
I
E
N
F
P
G
F
P
D
-
G
-
L
T
-
G
S
E
L
M
D
R
M
R
E
Q
S
T
K
F
G
-----
T
E
I
I
T
E
T
V
S
K
V
D
L
-
S
--
S
K
----
P
F
K
---
L
W
T
E
F
N
E
-
D
A
E
P
V
T
T
D
A
I
I
L
A
T
G
A
S
A
K
R
M
H
L
P
G
E
E
T
Y
W
Q
K
G
I
S
A
C
A
V
C
D
G
A
VP
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
C
E
E
A
Q
F
L
T
K
Y
G
S
K
V
F
M
L
V
R
K
D
H
L
R
A
S
T
I
M
Q
K
R
A
E
K
---
N
E
K
I
E
I
L
Y
N
T
V
A
L
E
--
A
K
G
D
G
---
K
L
---
L
N
A
L
R
I
K
N
T
K
K
N
E
E
T
D
-
L
P
V
S
G
L
F
Y
A
I
G
H
---
T
P
A
T
K
I
V
A
G
--
Q
V
D
-
T
D
E
A
G
Y
I
K
T
V
P
-----
G
-
S
-
S
L
T
S
V
P
G
F
F
A
A
G
D
V
Q
D
S
K
--
Y
--
R
Q
A
I
T
S
A
G
S
G
C
M
A
A
L
D
A
E
K
Y
L
---
T
S
L
--------
58
PsiBlast_CBE
56.13
33%
29
- C3 -
4YKF
16
AHPF_ECOLI
A:
[207-515]
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
-
R
T
G
L
----
M
G
E
R
F
-------
G
G
-----
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
-
P
-
K
-
T
E
-
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
VDVID
S
Q
S
A
S
K
L
I
P
A
A
-
V
-
E
--
G
G
----
L
H
Q
---
I
---
E
T
A
-
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
--
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
L
R
S
---
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
--
V
K
G
D
G
---
S
K
---
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
-
I
E
L
A
G
I
F
V
Q
I
G
L
---
L
P
N
T
N
W
L
E
G
--
A
V
E
-
R
N
R
M
G
E
I
I
I
-
D
-----
A
-
K
-
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
P
--
Y
--
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
--------------
11
PsiBlast_PDB
55.96
37%
44
- C3 -
3D8X
3
TRXB1_YEAST
A:
[13-326]
--------
V
T
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
A
R
A
E
I
-
K
P
-
I
L
Y
EG
M
M
A
N
G
I
A
A----
G
G
-----
Q
L
T
T
T
T
E
I
E
N
F
P
G
F
P
D
-
G
-
L
T
-
G
S
E
L
M
D
R
M
R
E
Q
S
T
K
F
G
-----
T
E
I
I
T
E
T
V
S
K
V
D
L
-
S
--
S
K
----
P
F
K
---
L
W
T
E
F
N
E
-
D
A
E
P
V
T
T
D
A
I
I
L
A
T
G
A
S
A
K
R
M
H
L
P
G
E
E
T
Y
W
Q
K
G
I
S
A
C
A
V
C
D
G
A
VP
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
C
E
E
A
Q
F
L
T
K
Y
G
S
K
V
F
M
L
V
R
K
D
H
L
R
A
S
T
I
M
Q
K
R
A
E
K
---
N
E
K
I
E
I
L
Y
N
T
V
A
L
E
--
A
K
G
D
G
---
K
L
---
L
N
A
L
R
I
K
N
T
K
K
N
E
E
T
D
-
L
P
V
S
G
L
F
Y
A
I
G
H
---
T
P
A
T
K
I
V
A
G
--
Q
V
D
-
T
D
E
A
G
Y
I
K
T
V
P
-----
G
-
S
-
S
L
T
S
V
P
G
F
F
A
A
G
D
V
Q
D
S
K
--
Y
--
R
Q
A
I
T
S
A
G
S
G
C
M
A
A
L
D
A
E
K
Y
L
---
T
S
L
E
-------
39
PsiBlast_CBE
54.62
37%
46
- C3 -
3ITJ
4
TRXB1_YEAST
B:
[25-338]
--------
V
T
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
A
R
A
E
I
-
K
P
-
I
LYEG
M
M
A
N
G
I
A
A----
G
G
-----
Q
L
T
T
T
T
E
I
E
N
F
P
G
F
P
D
-
G
-
L
T
-
G
S
E
L
M
D
R
M
R
E
Q
S
T
K
F
G
-----
T
E
I
I
T
E
T
V
S
K
V
D
L
-
S
--
S
K
----
P
F
K
---
L
W
T
E
F
N
E
-
D
A
E
P
V
T
T
D
A
I
I
L
A
T
G
A
S
A
K
R
M
H
L
P
G
E
E
T
Y
W
Q
K
G
I
S
A
C
A
V
C
D
G
A
VP
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
C
E
E
A
Q
F
L
T
K
Y
G
S
K
V
F
M
L
V
R
K
D
H
L
R
A
S
T
I
M
Q
K
R
A
E
K
---
N
E
K
I
E
I
L
Y
N
T
V
A
L
E
--
A
K
G
D
G
---
K
L
---
L
N
A
L
R
I
K
N
T
K
K
N
E
E
T
D
-
L
P
V
S
G
L
F
Y
A
I
G
H
---
T
P
A
T
K
I
V
A
G
--
Q
V
D
-
T
D
E
A
G
Y
I
K
T
V
P
-----
G
-
S
-
S
L
T
S
V
P
G
F
F
A
A
G
D
V
Q
D
S
K
--
Y
--
R
Q
A
I
T
S
A
G
S
G
C
M
A
A
L
D
A
E
K
Y
L
---
T
S
L
E
-------
38
PsiBlast_CBE
54.42
37%
45
- C3 -
3ITJ
2
TRXB1_YEAST
D:
[25-337]
--------
V
T
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
A
R
A
E
I
-
K
P
-
I
LYEG
M
M
A
N
G
I
A
A----
G
G
-----
Q
L
T
T
T
T
E
I
E
N
F
P
G
F
P
D
-
G
-
L
T
-
G
S
E
L
M
D
R
M
R
E
Q
S
T
K
F
G
-----
T
E
I
I
T
E
T
V
S
K
V
D
L
-
S
--
S
K
----
P
F
K
---
L
W
T
E
F
N
E
-
D
A
E
P
V
T
T
D
A
I
I
L
A
T
G
A
S
A
K
R
M
H
L
P
G
E
E
T
Y
W
Q
K
G
I
S
A
C
A
V
C
D
G
A
VP
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
C
E
E
A
Q
F
L
T
K
Y
G
S
K
V
F
M
L
V
R
K
D
H
L
R
A
------
R
A
E
K
---
N
E
K
I
E
I
L
Y
N
T
V
A
L
E
--
A
K
G
----------
L
N
A
L
R
I
K
N
T
K
K
N
E
E
T
D
-
L
P
V
S
G
L
F
Y
A
I
G
H
---
T
P
A
T
K
I
V
A
G
--
Q
V
D
-
T
D
E
A
G
Y
I
K
T
V
P
-----
G
-
S
-
S
L
T
S
V
P
G
F
F
A
A
G
D
V
Q
D
S
K
--
Y
--
R
Q
A
I
T
S
A
G
S
G
C
M
A
A
L
D
A
E
K
Y
L
---
T
S
L
--------