@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00244_1433S_: (2014-09-02 )
MERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWTADNAGEEGGEAPQEPQS
Atome Classification :
(55 SA)
.........10........20........30.---.......40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
VEK---GEELSCEE
R
N
L
L
S
V
A
Y
K
NVVGG
Q
R
A
A
W
R
V
L
S
S
I
E
Q
KSNEEGSEEKGP
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
EAGDAE
S
R
V
F
Y
L
K
MKG
D
Y
Y
R
Y
L
A
E
VATG
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
DI
S
K
KEMPPTN
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
EIANS
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
LSEDSY
K
D
S
T
L
I
M
Q
L
L
RDN
L
T
L
W
TADNAGEEGGEAPQEPQS
1
PsiBlast_PDB
98.22
99%
-90
- C11 -
3LW1
2
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
E
G
S
E
E
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
-
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
76
HHSearch
98.21
100%
-87
- C11 -
3IQU
1
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
E
G
S
E
E
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
16
PsiBlast_PDB
98.13
99%
-89
- C11 -
3IQJ
1
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
E
G
S
E
E
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
18
PsiBlast_PDB
98.09
99%
-90
- C11 -
3IQV
2
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
E
G
S
E
E
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
3
PsiBlast_PDB
97.70
100%
-89
- C11 -
4JC3
1
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
E
G
S
E
E
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
8
PsiBlast_PDB
97.29
100%
-91
- C11 -
3T0M
3
1433S_HUMAN
A:
[5-235]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
------
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
7
PsiBlast_PDB
97.23
100%
-90
- C11 -
3T0L
3
1433S_HUMAN
A:
[5-235]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
------
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
19
PsiBlast_PDB
97.17
99%
-88
- C11 -
3MHR
2
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
E
G
S
E
E
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
4
PsiBlast_PDB
97.09
100%
-92
- C11 -
4JDD
2
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
E
G
S
E
E
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
10
PsiBlast_PDB
96.96
100%
-89
- C11 -
4DHN
2
1433S_HUMAN
A:
[5-235]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
-------
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
31
PsiBlast_CBE
96.89
99%
-87
- C11 -
3P1Q
2
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
E
G
S
E
E
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
28
PsiBlast_CBE
96.84
99%
-87
- C11 -
3SMN
2
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
E
G
S
E
E
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
26
PsiBlast_CBE
96.84
99%
-88
- C11 -
3P1S
2
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
V
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
E
G
S
E
E
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
27
PsiBlast_CBE
96.81
99%
-88
- C11 -
3P1R
1
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
V
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
E
G
S
E
E
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
30
PsiBlast_CBE
96.72
99%
-87
- C11 -
3SML
2
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
E
G
S
E
E
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
29
PsiBlast_CBE
96.69
99%
-88
- C11 -
3SMM
2
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
E
G
S
E
E
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
11
PsiBlast_PDB
96.67
100%
-91
- C11 -
4DHO
2
1433S_HUMAN
A:
[5-235]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
-------
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
9
PsiBlast_PDB
96.46
100%
-92
- C11 -
4DHM
2
1433S_HUMAN
A:
[5-235]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
-------
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
5
PsiBlast_PDB
96.39
100%
-89
- C11 -
4IEA
1
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
-----
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
15
PsiBlast_PDB
96.09
100%
-99
- C11 -
4HRU
1
1433S_HUMAN
A:
[4-234]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
---------
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
-
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
12
PsiBlast_PDB
95.96
100%
-92
- C11 -
4DHT
2
1433S_HUMAN
A:
[5-235]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
-------
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
6
PsiBlast_PDB
95.92
100%
-102
- C11 -
3O8I
2
1433S_HUMAN
A:
[9-239]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
----------
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
---
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
---
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
21
PsiBlast_CBE
95.86
100%
-93
- C11 -
1YWT
1
1433S_HUMAN
B:
[1-231]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
---------
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
32
PsiBlast_CBE
95.84
99%
-83
- C11 -
3P1P
1
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
E
G
S
E
E
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
24
PsiBlast_CBE
95.33
99%
-82
- C11 -
3SPR
2
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
V
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
E
G
S
E
E
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
22
PsiBlast_CBE
95.29
100%
-94
- C11 -
1YWT
1
1433S_HUMAN
A:
[1-231]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
--------
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
13
PsiBlast_PDB
95.24
100%
-90
- C11 -
4DAT
1
1433S_HUMAN
A:
[4-234]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
----------
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
-
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
---
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
20
PsiBlast_PDB
95.14
99%
-90
- C11 -
4FL5
3
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
------
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
25
PsiBlast_CBE
94.99
99%
-93
- C11 -
3SMK
2
1433S_HUMAN
A:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
V
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
-------
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
----
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
14
PsiBlast_PDB
94.00
100%
-91
- C11 -
4DAU
1
1433S_HUMAN
A:
[4-234]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
C
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
----------
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
---
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
62
Fugue
88.80
73%
-86
- C11 -
1QJB
1
1433Z_HUMAN
A:
[1-232]
M
D
K
N
E
L
V
Q
K
A
K
L
A
E
Q
A
E
R
Y
D
D
M
A
A
C
M
K
S
V
T
E
Q
---
G
A
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
A
R
R
S
S
W
R
V
V
S
S
I
E
Q
K
------
E
K
K
Q
Q
M
A
R
E
Y
R
E
K
I
E
T
E
L
R
D
I
C
N
D
V
L
S
L
L
E
K
F
L
I
P
N
A
S
Q
A
E
S
K
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
A
G
D
D
K
K
G
I
V
D
Q
S
Q
Q
A
Y
Q
E
A
F
E
I
S
K
K
E
M
Q
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
E
K
A
C
S
L
A
K
T
A
F
D
E
A
I
A
E
L
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
S
D
T
--------------
47
PsiBlast_CBE
88.48
71%
-87
- C11 -
3CU8
1
1433Z_HUMAN
B:
[1-230]
M
D
K
N
E
L
V
Q
K
A
K
L
A
E
Q
A
E
R
Y
D
D
M
A
A
C
M
K
S
V
T
E
Q
---
G
A
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
A
R
R
S
S
W
R
V
V
S
S
I
E
Q
K
T
--
E
--
E
K
K
Q
Q
M
A
R
E
Y
R
E
K
I
E
T
E
L
R
D
I
C
N
D
V
L
S
L
L
E
K
F
L
I
P
N
A
S
Q
A
E
S
K
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
A
G
D
D
K
K
G
I
V
D
Q
S
Q
Q
A
Y
Q
E
A
F
E
I
S
K
K
E
M
Q
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
E
K
A
C
S
L
A
K
T
A
F
D
E
A
I
A
E
L
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
S
----------------
59
PsiBlast_CBE
88.41
71%
-85
- C11 -
3RDH
1
1433Z_HUMAN
D:
[4-233]
M
D
K
N
E
L
V
Q
K
A
K
L
A
E
Q
A
E
R
Y
D
D
M
A
A
C
M
K
S
V
T
E
Q
---
G
A
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
A
R
R
S
S
W
R
V
V
S
S
I
E
Q
K
T
--
E
G
A
E
K
K
Q
Q
M
A
R
E
Y
R
E
K
I
E
T
E
L
R
D
I
C
N
D
V
L
S
L
L
E
K
F
L
I
P
N
A
S
Q
A
E
S
K
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
A
G
D
D
K
K
G
I
V
D
Q
S
Q
Q
A
Y
Q
E
A
F
E
I
S
K
K
E
M
Q
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
E
K
A
C
S
L
A
K
T
A
F
D
E
A
I
A
E
L
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
S
----------------
51
PsiBlast_CBE
88.08
71%
-79
- C11 -
1QJB
1
1433Z_HUMAN
B:
[1-232]
M
D
K
N
E
L
V
Q
K
A
K
L
A
E
Q
A
E
R
Y
D
D
M
A
A
C
M
K
S
V
T
E
Q
---
G
A
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
A
R
R
S
S
W
R
V
V
S
S
I
E
Q
K
T
--
E
G
A
E
K
K
Q
Q
M
A
R
E
Y
R
E
K
I
E
T
E
L
R
D
I
C
N
D
V
L
S
L
L
E
K
F
L
I
P
N
A
S
Q
A
E
S
K
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
A
G
D
D
K
K
G
I
V
D
Q
S
Q
Q
A
Y
Q
E
A
F
E
I
S
K
K
E
M
Q
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
E
K
A
C
S
L
A
K
T
A
F
D
E
A
I
A
E
L
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
S
D
T
--------------
48
PsiBlast_CBE
87.60
71%
-84
- C11 -
3CU8
2
1433Z_HUMAN
A:
[2-230]
-
D
K
N
E
L
V
Q
K
A
K
L
A
E
Q
A
E
R
Y
D
D
M
A
A
C
M
K
S
V
T
E
Q
---
G
A
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
A
R
R
S
S
W
R
V
V
S
S
I
E
Q
K
T
--
E
G
A
E
K
K
Q
Q
M
A
R
E
Y
R
E
K
I
E
T
E
L
R
D
I
C
N
D
V
L
S
L
L
E
K
F
L
I
P
N
A
S
Q
A
E
S
K
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
A
G
D
D
K
K
G
I
V
D
Q
S
Q
Q
A
Y
Q
E
A
F
E
I
S
K
K
E
M
Q
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
E
K
A
C
S
L
A
K
T
A
F
D
E
A
I
A
E
L
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
S
----------------
44
PsiBlast_CBE
87.57
71%
-83
- C11 -
4BG6
4
1433Z_HUMAN
A:
[1-231]
M
D
K
N
E
L
V
Q
K
A
K
L
A
E
Q
A
E
R
Y
D
D
M
A
A
C
M
K
S
V
T
E
Q
---
G
A
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
A
R
R
S
S
W
R
V
V
S
S
I
E
Q
K
T
--
E
---
K
K
Q
Q
M
A
R
E
Y
R
E
K
I
E
T
E
L
R
D
I
C
N
D
V
L
S
L
L
E
K
F
L
I
P
N
A
S
Q
A
E
S
K
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
A
G
D
D
K
K
G
I
V
D
Q
S
Q
Q
A
Y
Q
E
A
F
E
I
S
K
K
E
M
Q
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
E
K
A
C
S
L
A
K
T
A
F
D
E
A
I
A
E
L
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
S
D
---------------
43
PsiBlast_CBE
87.45
71%
-79
- C11 -
4BG6
4
1433Z_HUMAN
B:
[2-230]
-
D
K
N
E
L
V
Q
K
A
K
L
A
E
Q
A
E
R
Y
D
D
M
A
A
C
M
K
S
V
T
E
Q
---
G
A
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
A
R
R
S
S
W
R
V
V
S
S
I
E
Q
K
T
--
E
G
A
E
K
K
Q
Q
M
A
R
E
Y
R
E
K
I
E
T
E
L
R
D
I
C
N
D
V
L
S
L
L
E
K
F
L
I
P
N
A
S
Q
A
E
S
K
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
A
G
D
D
K
K
G
I
V
D
Q
S
Q
Q
A
Y
Q
E
A
F
E
I
S
K
K
E
M
Q
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
E
K
A
C
S
L
A
K
T
A
F
D
E
A
I
A
E
L
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
S
----------------
46
PsiBlast_CBE
87.38
71%
-84
- C11 -
3NKX
2
1433Z_HUMAN
A:
[2-230]
-
D
K
N
E
L
V
Q
K
A
K
L
A
E
Q
A
E
R
Y
D
D
M
A
A
C
M
K
S
V
T
E
Q
---
G
A
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
A
R
R
S
S
W
R
V
V
S
S
I
E
Q
K
T
--
E
G
A
E
K
K
Q
Q
M
A
R
E
Y
R
E
K
I
E
T
E
L
R
D
I
C
N
D
V
L
S
L
L
E
K
F
L
I
P
N
A
S
Q
A
E
S
K
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
A
G
D
D
K
K
G
I
V
D
Q
S
Q
Q
A
Y
Q
E
A
F
E
I
S
K
K
E
M
Q
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
E
K
A
C
S
L
A
K
T
A
F
D
E
A
I
A
E
L
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
S
----------------
45
PsiBlast_CBE
87.38
71%
-86
- C11 -
3NKX
1
1433Z_HUMAN
B:
[1-230]
M
D
K
N
E
L
V
Q
K
A
K
L
A
E
Q
A
E
R
Y
D
D
M
A
A
C
M
K
S
V
T
E
Q
---
G
A
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
A
R
R
S
S
W
R
V
V
S
S
I
E
Q
K
T
--
E
--
E
K
K
Q
Q
M
A
R
E
Y
R
E
K
I
E
T
E
L
R
D
I
C
N
D
V
L
S
L
L
E
K
F
L
I
P
N
A
S
Q
A
E
S
K
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
A
G
D
D
K
K
G
I
V
D
Q
S
Q
Q
A
Y
Q
E
A
F
E
I
S
K
K
E
M
Q
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
E
K
A
C
S
L
A
K
T
A
F
D
E
A
I
A
E
L
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
S
----------------
61
PsiBlast_CBE
87.24
71%
-87
- C11 -
3RDH
1
1433Z_HUMAN
B:
[4-233]
M
D
K
N
E
L
V
Q
K
A
K
L
A
E
Q
A
E
R
Y
D
D
M
A
A
C
M
K
S
V
T
E
Q
---
G
A
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
A
R
R
S
S
W
R
V
V
S
S
I
E
Q
K
T
--
E
G
A
E
K
K
Q
Q
M
A
R
E
Y
R
E
K
I
E
T
E
L
R
D
I
C
N
D
V
L
S
L
L
E
K
F
L
I
P
N
A
S
Q
A
E
S
K
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
A
G
D
D
K
K
G
I
V
D
Q
S
Q
Q
A
Y
Q
E
A
F
E
I
S
K
K
E
M
Q
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
E
K
A
C
S
L
A
K
T
A
F
D
E
A
I
A
E
L
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
S
----------------
53
PsiBlast_CBE
87.08
71%
-82
- C11 -
1QJA
1
1433Z_HUMAN
B:
[1-229]
M
D
K
N
E
L
V
Q
K
A
K
L
A
E
Q
A
E
R
Y
D
D
M
A
A
C
M
K
S
V
T
E
Q
---
G
A
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
A
R
R
S
S
W
R
V
V
S
S
I
E
Q
K
T
--
E
G
A
E
K
K
Q
Q
M
A
R
E
Y
R
E
K
I
E
T
E
L
R
D
I
C
N
D
V
L
S
L
L
E
K
F
L
I
P
N
A
S
Q
A
E
S
K
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
----
K
K
G
I
V
D
Q
S
Q
Q
A
Y
Q
E
A
F
E
I
S
K
K
E
M
Q
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
E
K
A
C
S
L
A
K
T
A
F
D
E
A
I
A
E
L
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
60
PsiBlast_CBE
86.12
71%
-86
- C11 -
3RDH
1
1433Z_HUMAN
C:
[4-233]
M
D
K
N
E
L
V
Q
K
A
K
L
A
E
Q
A
E
R
Y
D
D
M
A
A
C
M
K
S
V
T
E
Q
---
G
A
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
A
R
R
S
S
W
R
V
V
S
S
I
E
Q
K
T
--
E
G
A
E
K
K
Q
Q
M
A
R
E
Y
R
E
K
I
E
T
E
L
R
D
I
C
N
D
V
L
S
L
L
E
K
F
L
I
P
N
A
S
Q
A
E
S
K
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
A
G
D
D
K
K
G
I
V
D
Q
S
Q
Q
A
Y
Q
E
A
F
E
I
S
K
K
E
M
Q
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
E
K
A
C
S
L
A
K
T
A
F
D
E
A
I
A
E
L
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
S
----------------
78
HHSearch
84.88
58%
-84
* C11 *
2NPM
1
?
A:
[27-259]
-
A
R
E
S
N
V
Y
M
A
K
L
A
E
Q
A
E
R
Y
D
E
M
A
K
Y
M
K
D
V
V
E
A
RQE--
E
L
T
V
E
E
R
N
L
L
S
V
A
Y
K
N
A
V
G
S
R
R
S
S
W
R
I
I
S
S
V
E
Q
K
E
H
S
R
N
A
E
D
A
S
K
M
C
G
K
Y
R
S
K
V
E
A
E
L
T
D
I
C
N
D
I
L
T
M
L
D
K
H
L
I
P
T
A
T
S
P
D
S
K
V
F
Y
F
K
M
K
G
D
Y
H
R
Y
I
S
E
F
S
T
G
D
S
K
Q
S
S
A
E
D
A
L
K
A
Y
K
D
A
T
V
V
A
-
K
D
L
E
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
L
N
E
P
R
A
A
I
D
M
A
K
E
A
F
E
M
A
I
E
Q
L
D
K
L
S
E
D
C
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
A
----------------
54
PsiBlast_CBE
84.55
71%
-87
- C11 -
1A38
1
1433Z_BOVIN
B:
[1-228]
M
D
K
N
E
L
V
Q
K
A
K
L
A
E
Q
A
E
R
Y
D
D
M
A
A
C
M
K
S
V
T
E
Q
---
G
A
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
A
R
R
S
S
W
R
V
V
S
S
I
E
Q
-------
E
K
K
Q
Q
M
A
R
E
Y
R
E
K
I
E
T
E
L
R
D
I
C
N
D
V
L
S
L
L
E
K
F
L
I
P
N
A
S
Q
A
E
S
K
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
A
G
D
D
K
K
G
I
V
D
Q
S
Q
Q
A
Y
Q
E
A
F
E
I
S
K
K
E
M
Q
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
E
K
A
C
S
L
A
K
T
A
F
D
E
A
I
A
-------
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
------------------
55
PsiBlast_CBE
84.48
71%
-87
- C11 -
1A38
1
1433Z_BOVIN
A:
[1-228]
M
D
K
N
E
L
V
Q
K
A
K
L
A
E
Q
A
E
R
Y
D
D
M
A
A
C
M
K
S
V
T
E
Q
---
G
A
E
L
S
N
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
A
R
R
S
S
W
R
V
V
S
S
I
E
Q
-------
E
K
K
Q
Q
M
A
R
E
Y
R
E
K
I
E
T
E
L
R
D
I
C
N
D
V
L
S
L
L
E
K
F
L
I
P
N
A
S
Q
A
E
S
K
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
A
G
D
D
K
K
G
I
V
D
Q
S
Q
Q
A
Y
Q
E
A
F
E
I
S
K
K
E
M
Q
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
E
K
A
C
S
L
A
K
T
A
F
D
E
A
I
A
-------
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
------------------
75
HHSearch
84.17
62%
-78
- C11 -
2BR9
1
1433E_HUMAN
A:
[4-233]
-
D
R
E
D
L
V
Y
Q
A
K
L
A
E
Q
A
E
R
Y
D
E
M
V
E
S
M
K
K
V
A
G
M
---
D
V
E
L
T
V
E
E
R
N
L
L
S
V
A
Y
K
N
V
I
G
A
R
R
A
S
W
R
I
I
S
S
I
E
Q
K
E
E
N
K
G
G
E
D
K
L
K
M
I
R
E
Y
R
Q
M
V
E
T
E
L
K
L
I
C
C
D
I
L
D
V
L
D
K
H
L
I
P
A
A
N
T
G
E
S
K
V
F
Y
Y
K
M
K
G
D
Y
H
R
Y
L
A
E
F
A
T
G
N
D
R
K
E
A
A
E
N
S
L
V
A
Y
K
A
A
S
D
I
A
M
T
E
L
P
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
D
R
A
C
R
L
A
K
A
A
F
D
D
A
I
A
E
L
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
77
HHSearch
83.96
62%
-77
- C11 -
3UBW
6
1433E_HUMAN
A:
[30-259]
-
D
R
E
D
L
V
Y
Q
A
K
L
A
E
Q
A
E
R
Y
D
E
M
V
E
S
M
K
K
V
A
G
M
---
D
V
E
L
T
V
E
E
R
N
L
L
S
V
A
Y
K
N
V
I
G
A
R
R
A
S
W
R
I
I
S
S
I
E
Q
K
E
E
N
K
G
G
E
D
K
L
K
M
I
R
E
Y
R
Q
M
V
E
T
E
L
K
L
I
C
C
D
I
L
D
V
L
D
K
H
L
I
P
A
A
N
T
G
E
S
K
V
F
Y
Y
K
M
K
G
D
Y
H
R
Y
L
A
E
F
A
T
G
N
D
R
K
E
A
A
E
N
S
L
V
A
Y
K
A
A
S
D
I
A
M
T
E
L
P
P
T
H
P
I
R
L
G
L
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
D
R
A
C
R
L
A
K
A
A
F
D
D
A
I
A
E
L
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
41
PsiBlast_CBE
76.77
99%
-16
- C11 -
3P1N
1
1433S_HUMAN
A:
[5-235]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
-
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
E
G
S
E
E
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
36
PsiBlast_CBE
76.28
99%
-20
- C11 -
4DHR
2
1433S_HUMAN
A:
[5-235]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
-
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
-------
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
33
PsiBlast_CBE
76.20
99%
-17
- C11 -
4FL5
1
1433S_HUMAN
B:
[6-236]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
-
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
-------
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
37
PsiBlast_CBE
75.74
99%
-17
- C11 -
4DHQ
2
1433S_HUMAN
A:
[5-235]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
-
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
E
E
----
K
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
34
PsiBlast_CBE
75.70
99%
-16
- C11 -
4DHU
2
1433S_HUMAN
A:
[5-235]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
-
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
-------
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
35
PsiBlast_CBE
75.46
99%
-18
- C11 -
4DHS
2
1433S_HUMAN
A:
[5-235]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
-
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
-------
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
38
PsiBlast_CBE
74.96
99%
-18
- C11 -
4DHP
2
1433S_HUMAN
A:
[5-235]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
-
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
-------
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------
39
PsiBlast_CBE
66.68
99%
-17
- C11 -
3UX0
3
1433S_HUMAN
A:
[5-235]
M
E
R
A
S
L
I
Q
K
A
K
L
A
E
Q
A
E
R
Y
E
D
M
A
A
F
M
K
G
A
V
E
K
---
G
E
E
L
S
-
E
E
R
N
L
L
S
V
A
Y
K
N
V
V
G
G
Q
R
A
A
W
R
V
L
S
S
I
E
Q
K
S
N
-------
G
P
E
V
R
E
Y
R
E
K
V
E
T
E
L
Q
G
V
C
D
T
V
L
G
L
L
D
S
H
L
I
K
E
A
G
D
A
E
S
R
V
F
Y
L
K
M
K
G
D
Y
Y
R
Y
L
A
E
V
A
T
G
D
D
K
K
R
I
I
D
S
A
R
S
A
Y
Q
E
A
M
D
I
S
K
K
E
M
P
P
T
N
P
I
R
L
G
L
A
L
N
F
S
V
F
H
Y
E
I
A
N
S
P
E
E
A
I
S
L
A
K
T
T
F
D
E
A
M
A
D
L
H
T
L
S
E
D
S
Y
K
D
S
T
L
I
M
Q
L
L
R
D
N
L
T
L
W
T
-----------------