@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MSHR_HUMAN: (2016-01-11 )
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
Atome Classification :
(20 SA)
.........10........20........30........40........50...---.....60........70........80........90........100...-....110..-----.....120.......130.......140.......150.......160.......170.......180-------------..----.----.------------------.-----------.-.--.190-------------------.......200.......210.......220....-------------------------------------------------------------------------------------------------------------------------------------.------------------------------------------------------------------------------------------------------------------------.---------------.230--.........240.......250.......260.......270.......280.....-..290.......300.......310.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAVQG
S
Q
R
R
L
L
GSLNSTPTAIPQLGLAANQTG
A
R
C
L
E
V
SISD
G
L
F
L
S
L
G
L
V
S
L
V
---EN
A
L
V
V
A
T
IAKNRNLH
S
P
M
Y
C
F
I
C
C
L
A
L
S
D
L
L
VSG
S
N
V
L
E
T
A
V
I
L
L
LEA
G
A
-
L
V
A
R
A
A
V
L
Q
-----
Q
L
D
N
V
I
D
V
I
T
C
S
S
M
L
S
S
L
C
F
L
G
A
I
A
V
D
R
Y
I
S
I
F
Y
A
L
R
Y
H
S
I
VT
L
P
R
A
R
R
A
V
A
A
I
W
V
A
S
V
V
F
S
T
L
F
I
A
--------------
Y
Y
----
D
----
H
------------------
V
-----------
A
-
V
--
L
L
C
L
-------------------
V
V
F
F
L
A
M
L
V
L
M
A
V
L
Y
V
H
M
L
A
R
A
C
Q
H
A
Q
G
I
A
R
L
H
K
-------------------------------------------------------------------------------------------------------------------------------------R------------------------------------------------------------------------------------------------------------------------Q---------------RP----VHQGFGLK
G
A
V
T
L
T
I
L
L
G
I
F
F
L
C
W
G
P
F
F
L
H
L
T
L
I
V
LCPEHPTC
G
C
I
FK
N
F
N
L
F
L
A
L
I
-
I
C
N
A
I
I
D
P
L
I
Y
A
F
H
S
Q
E
L
R
R
T
L
K
E
V
LTCSW
29
HHSearch
92.40
26%
-170
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[45-477]
------------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
---
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
-
K
M
W
---
T
F
G
---
N
-----
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H------------
W
Y
----
R
ATH
Q
E
A
I
N
C
Y
A
EETCCDFFTN
Q
-
A
-----------
Y
-
A
--
I
A
S
S
-------------------
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
-
T
P
-----------------------------------------------------------------------------------------------------------------------
N
R
A
K
R
V
I
T
T
F
R
TGTWD
A
Y
----
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
----
R
K
E
V
Y
I
L
L
N
W
I
G
-
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--
4
PsiBlast_PDB
86.18
27%
-183
- C1 -
2YCZ
2
ADRB1_MELGA
A:
[9-297]
--------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
---
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
K
C
Y
Q
----
D
----
P
GCCDFVTN
R
A
--------
Y
-----------
A
-
I
--
A
S
S
I
-------------------
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
-
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
A
S
K
-------------------------------------------------------------------------------------------------------------------------------------
R
------------------------------------------------------------------------------------------------------------------------
K
---------------
R
-----
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
-
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
---
L
G
-
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--
16
PsiBlast_PDB
86.06
26%
-170
- C1 -
4GBR
1
ADRB2_HUMAN
A:
[9-284]
------------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
--
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
T
K
T
W
T
-
F
---
G
N
F
W
C
-----
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
---
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
--------------
M
H
WYRA
T
----
H
------------------
Q
-----------
E
-
A
--
I
N
C
Y
A
EET
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
K
I
D
K
F
C
L
-------------------------------------------------------------------------------------------------------------------------------------
K
------------------------------------------------------------------------------------------------------------------------
E
---------------
H
------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
-
V
N
I
V
H
V
I
Q
D
N
----
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--
11
PsiBlast_PDB
86.04
27%
-197
- C1 -
4AMJ
12
ADRB1_MELGA
A:
[2-299]
-------------------------------
G
A
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
---
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
K
C
Y
Q
----
D
----
P
GCCDFVTN
R
A
--------
Y
-----------
A
-
I
--
A
S
S
I
-------------------
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
-
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
---
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
-
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
---
L
G
-
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---
12
PsiBlast_PDB
85.97
27%
-195
- C1 -
3ZPQ
11
ADRB1_MELGA
A:
[2-299]
-------------------------------
G
A
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
---
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
K
C
Y
Q
----
D
----
P
GCCDFVTN
R
A
--------
Y
-----------
A
-
I
--
A
S
S
I
-------------------
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
-
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
---
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
-
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
---
L
G
-
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---
8
PsiBlast_PDB
85.86
27%
-201
- C1 -
2Y02
13
ADRB1_MELGA
A:
[3-299]
--------------------------------
A
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
---
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
K
C
Y
Q
----
D
----
P
GCCDFVTN
R
A
--------
Y
-----------
A
-
I
--
A
S
S
I
-------------------
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
-
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
---
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
-
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
---
L
G
-
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---
2
PsiBlast_PDB
85.85
27%
-181
- C1 -
2YCW
7
ADRB1_MELGA
A:
[3-297]
--------------------------------
A
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
---
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
K
C
Y
Q
----
D
----
P
GCCDFVTN
R
A
--------
Y
-----------
A
-
I
--
A
S
S
I
-------------------
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
-
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
A
S
K
-------------------------------------------------------------------------------------------------------------------------------------
R
------------------------------------------------------------------------------------------------------------------------
K
---------------
R
-----
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
-
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
---
L
G
-
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--
18
PsiBlast_PDB
85.48
26%
-178
- C1 -
4LDL
3
ADRB2_HUMAN
A:
[186-461]
------------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
--
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
T
K
T
W
T
-
F
---
G
N
F
W
C
-----
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
---
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
--------------
M
H
WYRA
T
----
H
------------------
Q
-----------
E
-
A
--
I
N
C
Y
A
EETCC
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
---
K
F
A
L
-------------------------------------------------------------------------------------------------------------------------------------
K
------------------------------------------------------------------------------------------------------------------------
E
---------------
H
------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
-
V
N
I
V
H
V
I
Q
D
N
----
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--
17
PsiBlast_PDB
85.46
26%
-179
- C1 -
4LDE
3
A:
[186-461]
------------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
--
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
T
K
T
W
T
-
F
---
G
N
F
W
C
-----
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
---
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
--------------
M
H
WYRA
T
----
H
------------------
Q
-----------
E
-
A
--
I
N
C
Y
A
EETCCD
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
---
K
F
A
L
-------------------------------------------------------------------------------------------------------------------------------------
K
------------------------------------------------------------------------------------------------------------------------
E
---------------
H
------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
-
V
N
I
V
H
V
I
Q
D
N
----
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--
7
PsiBlast_PDB
85.43
27%
-198
- C1 -
2Y01
12
ADRB1_MELGA
A:
[3-299]
--------------------------------
A
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
---
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
K
C
Y
Q
----
D
----
P
GCCDFVTN
R
A
--------
Y
-----------
A
-
I
--
A
S
S
I
-------------------
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
-
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
---
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
-
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
---
L
G
-
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---
13
PsiBlast_PDB
85.42
27%
-195
- C1 -
3ZPR
11
ADRB1_MELGA
A:
[2-299]
-------------------------------
G
A
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
---
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
K
C
Y
Q
----
D
----
P
GCCDFVTN
R
A
--------
Y
-----------
A
-
I
--
A
S
S
I
-------------------
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
-
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
L
--
M
R
E
H
K
A
L
K
---
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
-
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
---
L
G
-
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
----
6
PsiBlast_PDB
85.37
27%
-201
- C1 -
2Y00
13
ADRB1_MELGA
A:
[3-299]
--------------------------------
A
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
---
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
K
C
Y
Q
----
D
----
P
GCCDFVTN
R
A
--------
Y
-----------
A
-
I
--
A
S
S
I
-------------------
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
-
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
---
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
-
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
---
L
G
-
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---
19
PsiBlast_PDB
85.23
26%
-178
- C1 -
4LDO
3
A:
[186-461]
------------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
--
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
T
K
T
W
T
-
F
---
G
N
F
W
C
-----
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
---
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
--------------
M
H
WYRA
T
----
H
------------------
Q
-----------
E
-
A
--
I
N
C
Y
A
EETCC
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
---
K
F
A
L
-------------------------------------------------------------------------------------------------------------------------------------
K
------------------------------------------------------------------------------------------------------------------------
E
---------------
H
------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
-
V
N
I
V
H
V
I
Q
D
N
----
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--
10
PsiBlast_PDB
85.04
27%
-198
- C1 -
2Y04
13
ADRB1_MELGA
A:
[3-299]
--------------------------------
A
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
---
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
K
C
Y
Q
----
D
----
P
GCCDFVTN
R
A
--------
Y
-----------
A
-
I
--
A
S
S
I
-------------------
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
-
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
---
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
-
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
---
L
G
-
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---
32
HHSearch
84.49
25%
-169
- C1 -
3EML
13
ENLYS_BPT4
A:
[25-468]
-----------------------------------------
I
T
V
E
L
A
I
A
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
---
G
F
---
C
A
---
A
C
-----
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
--------------
G
W
----
N
----
N
CGQSQGCGEGQVACLFED
V
VP
M
--------
N
-
Y
M
V
Y
F
N
F
-------------------
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
--------------------------------------------------------------------------------------------------------
A
---------------
Y
R
----
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
--
A
P
L
W
L
M
Y
L
A
I
V
L
S
-
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
15
PsiBlast_PDB
84.42
26%
-179
- C1 -
4QKX
2
ADRB2_HUMAN
A:
[186-461]
------------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
--
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
C
I
L
T
K
T
W
T
-
F
---
G
N
F
W
C
-----
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
---
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
--------------
M
H
WYRA
T
----
H
------------------
Q
-----------
E
-
A
--
I
N
C
Y
A
EETCC
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
---
K
F
A
L
-------------------------------------------------------------------------------------------------------------------------------------
K
------------------------------------------------------------------------------------------------------------------------
E
---------------
H
------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
-
V
N
I
V
H
V
I
Q
D
N
----
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--
3
PsiBlast_PDB
84.41
27%
-182
- C1 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
--------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
---
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
K
C
Y
Q
----
D
----
P
GCCDFVTN
R
A
--------
Y
-----------
A
-
I
--
A
S
S
I
-------------------
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
-
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
A
S
K
-------------------------------------------------------------------------------------------------------------------------------------
R
------------------------------------------------------------------------------------------------------------------------
K
---------------
R
-----
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
-
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
---
L
G
-
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
-------
9
PsiBlast_PDB
84.38
27%
-200
- C1 -
2Y03
9
ADRB1_MELGA
A:
[3-299]
--------------------------------
A
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
---
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
K
C
Y
Q
----
D
----
P
GCCDFVTN
R
A
--------
Y
-----------
A
-
I
--
A
S
S
I
-------------------
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
-
L
R
V
Y
R
E
A
K
E
Q
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
---
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
-
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
---
L
G
-
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---
28
HHSearch
84.32
22%
-166
- C1 -
3UON
4
ACM2_HUMAN (first)
A:
[28-457]
------------------------------------------
L
V
A
G
S
L
S
L
V
T
I
I
---
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
I
-
G
Y
W
---
P
L
G
P
--------
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
--------------
F
W
----
Q
----
F
I
V
GVRTVE----------
D
GECYIQFFSN
A
A
V
T
--
F
G
T
A
-------------------
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSP---------------------------------------------------------------------------------------------------------
S
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
---------------
A
Y
----
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
--
I
P
--
N
T
V
W
T
I
G
Y
W
L
C
-
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---
1
PsiBlast_PDB
83.72
27%
-195
- C1 -
2VT4
8
ADRB1_MELGA
A:
[10-297]
---------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
---------
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
---
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
K
C
Y
Q
----
D
----
P
GCCDFVTN
R
A
--------
Y
-----------
A
-
I
--
A
S
S
I
-------------------
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
-
L
R
V
Y
R
E
A
K
E
Q
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
-
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
---
L
G
-
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---