@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O51F1_HUMAN: (2016-01-12 )
MLQNQDTMEILSNSTSKFPTFLLTGIPGLESAHVWISIPFCCFYAIALSGNSVILFVIITQQSLHEPMYYFLFRLSATDLGLTVSSLSTTLGILWFEAREISLYSCIVQMFFLHGFTFMESGVLVATAFDRYVAICDPLRYTTILTNSRIIQMGLLMITRAIVLILPLLLLLKPLYFCRMNALSHSYCYHPDVIQLACSDIRANSICGLIDLILTTGIDTPCIVLSYILIIHSVLRIASPEEWHKVFSTCVSHVGAVAFFYIHMLSLSLVYRYGRSAPRVVHSVMANVYLLLPPVLNPIIDSVKTKQIRKAMLSLLLTK
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.--.....--...10........20......---..30---........--.40----.........--50....----...---.60..-.......70.....-...80...-..-...-90....-..-..100.....-------..110--.....-----------....120......-..130.......140..---.....150-----------------------------.......--.160....---.---..170.......180..---......190.--------------------------------------------......------.-200.-........210-....-.------..220...-------....230.-......---------.------------------------------------------------------------------------------------------------------------------------------------------------------------------240-----------------------------------------------------------------------------------------------------------------------------------------------------------------.........250---------.--......260...-....270...----------.--.----------.-.280....--------------------...290....----...300.......310.......------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--LQN
Q
D
--
T
M
E
I
L
SNSTSKF
P
T
F
L
L
TGIP---GLE----S
A
H
V
W
I
S
I
--
P
F
-----
C
C
F
Y
A
I
A
LS--GN
S
V
I
L
----
F
V
I
---
I
T-
Q
Q
-
S
LHE
P
M
Y
Y
F
L
F
R
LS-ATDL
G
L
T
V
-
S
S
-
L
S
T
-
T
L
G
I
L
W
-
F
E-A
R
E
I
S
L
Y
S
C
I
-------
V
Q
M
----
F
F
L
H
G
-----------
F
T
F
M
ES-
G
V
L
V
A
T-AFD
R
Y
V
A
I
CDP
L
R
Y
T
T
I
---LTN
S
R
I
I
------------------------------
Q
M
G
L
L
M
I
--
T
R
A
I
V
L
I
L
---
P
---
L
L
L
L
L
K
P
L
Y
F
C
R
M
N
-AL---SHSYCYH-
P
D
--------------------------------------------
V
I
Q
L
A
C
------
S
-D--I-R
A
N
S
I
C
G
L
I
D
L
-
I
L
TT-G------ID
T
P
C
I
V
L
-------
S
Y
I
L
I
I
-
H
-
S
V
L
RIA---------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
W
H
K
V
F
S
T
C
V
S
---------
H
--
V
G
A
V
A
F
F
Y
I
H
M
L
-
S
L
S
L
V
Y
R
YGR----------S--
A
----------
P
-
R
V
V
H
S
V
M
A
--------------------
N
V
Y
L
LLP
P
V
L
----
N
P
I
I
D
S
V
K
T
K
Q
I
R
K
A
M
L
S
L
LLTK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
90.74
17%
-139
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[39-477]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
V
G
M
G
I
--
V
M
-----
S
L
I
V
L
A
I
V
F
--
G
N
V
L
V
I
----
T
A
I
---
A
K
-
F
E
-
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
-
C
A
D
L
V
M
G
L
-
A
V
-
V
P
F
-
G
A
A
H
I
L
-
M
K
-
M
W
T
F
G
N
F
W
C
E
-------
F
W
T
----
S
I
D
V
L
-----------
C
V
T
A
S
I
-
E
T
L
C
V
I
-
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
------------------------------
V
I
I
L
M
V
W
--
I
V
S
G
L
T
S
F
---
L
---
P
I
Q
M
H
W
Y
R
A
T
-----
H
Q
---
E
A
I
N
C
Y
A
-
E
E
------------------------------------------------
T
C
------
C
-
D
--
F
-
F
T
N
Q
A
Y
A
I
A
S
S
-
I
V
S
F
-
Y
------
V
P
L
V
I
M
V
F
-------
V
Y
S
R
V
F
-
Q
-
E
A
K
R
Q
L
---------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKF-
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
H
K
A
L
K
T
L
G
I
---------
I
--
M
G
T
F
T
L
C
W
L
P
F
F
-
I
V
N
I
V
H
V
I
Q
D
----------
N
--
L
----------
I
-
R
K
E
V
Y
I
L
L
--------------------
N
W
I
G
Y
V
N
S
G
F
----
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
89.46
18%
-118
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
G
T
E
G
P
N
--
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
---
Y
L
A
----
E
P
W
Q
F
S
M
L
A
A
Y
M
-----
F
L
L
I
M
L
G
F
P
--
I
N
F
L
T
L
----
Y
V
T
---
V
Q
-
H
K
-
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
-
V
A
D
L
F
M
V
F
-
G
G
-
F
T
T
-
T
L
Y
T
S
L
-
H
G
-
Y
F
V
F
G
P
T
G
C
N
-------
L
E
G
----
F
F
A
T
L
-----------
G
G
E
I
A
L
-
W
S
L
V
V
L
-
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
------------------------------
G
V
A
F
T
W
V
--
M
A
L
A
C
A
A
P
---
P
---
L
V
------
G
W
S
R
-------------
Y
I
-
P
E
--------------------------------------------
G
M
Q
C
S
C
G
I
DYYT
P
-
H
--
E
-
E
T
N
N
E
S
F
V
I
Y
M
-
F
V
V
H
F
I
------
I
P
L
I
V
I
F
F
-------
C
Y
G
Q
L
V
-
F
-
T
V
K
E
A
A
AQQQESA
T
-
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
V
I
I
---------
M
--
V
I
A
F
L
I
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
T
H
Q
----------
G
--
S
----------
D
F
G
P
I
F
M
T
I
P
--------------------
A
F
F
A
K
T
S
A
V
Y
----
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
KNPLGDDEA
S
T
T
V
S
K
TETSQVAPA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
88.21
18%
-128
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
G
T
E
G
P
N
--
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
---
Y
L
A
----
E
P
W
Q
F
S
M
L
--
A
A
-----
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
----
Y
V
T
---
V
Q
-
H
K
-
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
-
V
A
D
L
F
M
V
F
-
G
G
-
F
T
T
-
T
L
Y
T
S
L
-
H
G
-
Y
F
V
F
G
P
T
G
C
N
-------
L
E
G
----
F
F
A
T
L
-----------
G
G
E
I
A
L
-
W
S
L
V
V
L
-
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
------------------------------
G
V
A
F
T
W
V
--
M
A
L
A
C
A
A
P
---
P
---
L
V
G
W
S
R
-------------------
Y
I
-
P
E
--------------------------------------------
G
M
Q
C
S
C
------
G
I
D
--
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-
V
I
Y
M
-
F
------
V
V
H
F
I
I
P
L
-------
I
V
I
F
F
C
-
Y
-
G
Q
L
V
F
T
VKEAAASAT
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
V
I
I
---------
M
--
V
I
A
F
L
I
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
T
H
Q
----------
G
--
S
----------
D
F
G
P
I
F
M
T
I
P
--------------------
A
F
F
A
K
T
S
A
V
Y
----
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
KNPSTTVSKTETS
Q
V
A
P
A------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
85.64
16%
-133
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
L
--
S
Y
-----
C
A
L
I
L
A
I
V
F
--
G
N
G
L
V
C
----
M
A
V
---
L
K
-
E
R
-
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
-
V
A
D
L
L
V
A
T
-
L
V
-
M
P
W
-
V
V
Y
L
E
V
T
G
G
-
V
W
N
F
S
R
I
C
C
D
-------
V
F
V
----
T
L
D
V
M
-----------
M
C
T
A
S
I
-
W
N
L
C
A
I
-
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
------------------------------
L
M
I
T
A
V
W
--
V
L
A
F
A
V
S
C
---
P
---
L
L
F
G
F
N
T
T
--------
G
---
D
P
T
V
C
S
I
-
S
N
------------------------------------------------------------------
P
D
F
V
I
Y
S
S
-
V
V
S
F
-
Y
------
L
P
F
G
V
T
V
L
-------
V
Y
A
R
I
Y
-
V
-
V
L
K
Q
R
R
---------
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
T
Q
M
V
A
I
---------
V
--
L
G
A
F
I
V
C
W
L
P
F
F
-
L
T
H
V
L
N
T
H
C
Q
----------
T
C-
H
----------
V
-
S
P
E
L
Y
S
A
T
--------------------
T
W
L
G
Y
V
N
S
A
L
----
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
85.58
16%
-153
- C4 -
3EML
13
ENLYS_BPT4
A:
[21-468]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
Y
I
T
--
V
E
-----
L
A
I
A
V
L
A
I
L
--
G
N
V
L
V
C
----
W
A
V
---
W
L
-
N
S
-
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
-
A
A
D
I
A
V
G
V
-
L
A
-
I
P
F
-
A
I
T
I
S
T
----
G
F
C
A
A
C
H
G
C
L
-------
F
I
A
----
C
F
V
L
V
-----------
L
T
Q
S
S
I
-
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
------------------------------
G
I
I
A
I
C
W
--
V
L
S
F
A
I
G
L
---
T
---
P
M
L
G
W
N
N
C
G
Q
-----------
S
Q
G
C
G
E
-
G
Q
--------------------------------------------
V
A
---
C
------
L
-
F
ED
V
-
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
V
-
L
------
V
P
L
L
L
M
L
G
-------
V
Y
L
R
I
F
-
L
-
A
A
R
R
Q
L
---------
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
L
A
I
---------
I
--
V
G
L
F
A
L
C
W
L
P
L
H
-
I
I
N
C
F
T
F
F
C
P
----------
D
CS
H
----------
A
-
P
L
W
L
M
Y
L
A
--------------------
I
V
L
S
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
83.84
15%
-140
* C4 *
2Z73
5
OPSD_TODPA
A:
[29-332]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
----
A
V
Y
Y
S
L
G
I
--
F
I
-----
G
I
C
G
I
I
G
C
G
--
G
N
G
I
V
I
----
Y
L
F
---
T
K
-
T
K
-
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
-
F
S
D
F
T
F
S
L
-
V
N
G
F
P
L
-
M
T
I
S
C
F
-
L
K
-
K
W
I
F
G
F
A
A
C
K
-------
V
Y
G
----
F
I
G
G
I
-----------
F
G
F
M
S
I
-
M
T
M
A
M
I
-
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
------------------------------
I
M
I
I
F
V
W
--
L
W
S
V
L
W
A
I
---
G
---
P
I
F
G
W
G
A
Y
T
L
-----
E
G
---
V
L
C
N
C
S
F
-
D
Y
--------------------------------------------
I
S
------------
R
--
D
-
S
T
T
R
S
N
I
L
C
M
F
-
I
L
G
F
-
F
------
G
P
I
L
I
I
F
F
-------
C
Y
F
N
I
V
-
M
-
S
V
S
N
H
E
---------
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
A
K
I
S
I
V
---------
I
--
V
S
Q
F
L
L
S
W
S
P
Y
A
-
V
V
A
L
L
A
Q
F
G
P
----------
L
E-
W
----------
V
-
T
P
Y
A
A
Q
L
P
--------------------
V
M
F
A
K
A
S
A
I
H
----
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
82.40
17%
-122
- C4 -
1U19
14
OPSD_BOVIN
A:
[39-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
S
M
L
A
A
--
Y
M
-----
F
L
L
I
M
L
G
F
P
--
I
N
F
L
T
L
----
Y
V
T
---
V
Q
-
H
K
-
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
-
V
A
D
L
F
M
V
F
-
G
G
-
F
T
T
-
T
L
Y
T
S
L
-
H
G
-
Y
F
V
F
G
P
T
G
C
N
-------
L
E
G
----
F
F
A
T
L
-----------
G
G
E
I
A
L
-
W
S
L
V
V
L
-
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
------------------------------
M
G
V
A
F
T
W
--
V
M
A
L
A
C
A
A
---
P
---
P
L
V
G
W
S
R
Y
I
P
-----
E
G
---
M
Q
C
S
C
G
I
-
D
Y
--------------------------------------------
Y
T
P
---------
H
-
E
--
E
-
T
N
N
E
S
F
V
I
Y
M
F
-
V
V
H
F
-
I
------
I
P
L
I
V
I
F
F
-------
C
Y
G
Q
L
V
-
F
-
T
V
K
E
A
A
---------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
V
I
I
---------
M
--
V
I
A
F
L
I
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
T
H
Q
G---------
S
--
D
----------
F
-
G
P
I
F
M
T
I
P
--------------------
A
F
F
A
K
T
S
A
V
Y
----
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
80.15
17%
-137
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
I
V
L
--
V
A
-----
G
S
L
S
L
V
T
I
I
--
G
N
I
L
V
M
----
V
S
I
---
K
V
-
N
R
-
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
-
C
A
D
L
I
I
G
V
-
F
S
-
M
N
L
-
Y
T
L
Y
T
V
-
I
G
-
Y
W
P
L
G
P
V
V
C
D
-------
L
W
L
----
A
L
D
Y
V
-----------
V
S
N
A
S
V
-
M
N
L
L
I
I
-
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
------------------------------
M
M
I
A
A
A
W
--
V
L
S
F
I
L
W
A
---
P
---
A
I
L
F
W
Q
F
I
V
G
V
R
---
T
V
---
E
D
G
E
C
Y
I
-
Q
F
--------------------------------------------
F
-------------------
S
N
A
A
V
T
F
G
T
A
-
I
A
A
F
-
Y
------
L
P
V
I
I
M
T
V
-------
L
Y
W
H
I
S
-
R
-
A
S
K
S
R
I
---------
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
K
V
T
R
T
I
L
A
---------
I
--
L
L
A
F
I
I
T
W
A
P
Y
N
-
V
M
V
L
I
N
T
F
C
A
----------
P
--
C
----------
I
-
P
N
T
V
W
T
I
G
--------------------
Y
W
L
C
Y
I
N
S
T
I
----
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
76.89
15%
-132
- C4 -
2KS9
1
NK1R_HUMAN
A:
[32-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
W
A
A
--
A
Y
-----
T
V
I
V
V
T
S
V
V
--
G
N
V
V
V
M
----
W
I
I
---
L
A
-
H
K
-
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
-
F
A
E
A
S
M
A
A
-
F
N
-
T
V
V
-
N
F
T
Y
A
V
-
H
N
-
E
W
Y
Y
G
L
F
Y
C
K
-------
F
H
N
----
F
F
P
I
A
-----------
A
V
F
A
S
I
-
Y
S
M
T
A
V
-
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
------------------------------
V
V
I
C
V
I
W
--
V
L
A
L
L
L
A
F
---
P
---
Q
G
Y
Y
S
T
T
E
T
------
M
P
---
S
R
V
V
C
M
I
-
E
W
--------------------------------------------
P
E
H
---------
P
-
N
--
K
-
I
Y
E
K
V
Y
H
I
C
V
T
-
V
L
I
Y
-
F
------
L
P
L
L
V
I
G
Y
-------
A
Y
T
V
V
G
-
I
-
T
L
W
A
S
E
---------
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
V
K
M
M
I
V
---------
V
--
V
C
T
F
A
I
C
W
L
P
F
H
-
I
F
F
L
L
P
Y
I
N
P
----------
D
--
L
YLKK------
F
-
I
Q
Q
V
Y
L
A
I
--------------------
M
W
L
A
M
S
S
T
M
Y
----
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
74.67
16%
-142
- C3 -
4CZX
3
PAN2_NEUCR
A:
[1-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P
H
M
--
M
D
S
R
D
WT
Q
L
G
C
V
A
Y
P
S
P
I
H
P
D
Y
H
A
G
P
A
S
---
T
I
A
F
D
NQ
D
E
L
L
W
I
G
T
--
Q
K
-------
G
F
A
G
S
F
I
--
G
R
E
L
K
R
----
F
T
A
---
F
R
I
H
P
-
E
T
D
G
P
L
R
Q
F
L
F
V
D
K
G
V
I
F
L
G
S
R
S
-
V
Y
-
M
A
A
-
R
S
G
V
P
I
-
W
S
-
I
R
H
E
S
M
Q
D
L
R
-------
A
M
S
----
F
T
S
K
G
---------------
T
S
-
E
I
L
V
A
G
--
W
Q
N
K
M
L
V
I
D
V
N
K
G
E
V
V
---
K
E
L
P
T
Q
D
------------------------------
Q
Y
S
F
L
K
M
--
S
R
Y
I
C
A
A
T
---
N
KG-
T
V
N
I
L
D
P
I
T
F
T
-----
I
---
K
K
Q
W
Q
A
H
-
G
A
--------------------------------------------
F
I
N
D
L
D
------
T
-
S
--
N
----------
D
F
-
I
V
T
C
-
G
G
SHRQT
H
N
T
P
A
I
L
D
-------
P
Y
V
K
V
F
-
D
L
K
N
M
S
A
M
---------
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
F
A
P
L
A
A
H
V
R
M
---------
H
PR
M
L
T
T
A
I
V
V
N
Q
A
G
-
Q
I
H
V
T
D
L
L
N
P
----------
S
--
N
----------
S
-
Q
V
C
Y
T
Q
P
Q
--------------------
G
V
V
L
H
F
D
V
S
R
TGE
G
K
A
L
A
D
N
K
H
N
T
Y
V
W
G
S
P
N
K
I
Q
F
T
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
72.54
16%
-119
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
Y
V
V
I
I
--
A
Y
-----
A
L
V
F
L
L
S
L
L
--
G
N
S
L
V
M
----
L
V
I
---
L
Y
-
S
R
-
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
-
L
A
D
L
L
F
A
L
-
T
--
L
P
I
-
W
A
A
S
K
--
V
N
-
G
W
I
F
G
T
F
L
C
K
-------
V
V
S
----
L
L
K
E
V
-----------
N
F
Y
S
G
I
-
L
L
L
A
C
I
-
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
----
Q
K
R
H
L
V
K
------------------------------
F
V
C
L
G
C
W
--
G
L
S
M
N
L
S
L
---
P
---
F
F
L
F
R
Q
A
Y
H
P
-----
N
N
---
S
S
P
V
C
Y
E
-
V
L
--------------------------------------------
G
N
----------
D
-
T
--
A
-
K
W
R
M
V
L
R
I
L
P
H
-
T
F
G
F
-
I
------
V
P
L
F
V
M
L
F
-------
C
Y
G
F
T
L
-
R
-
T
L
F
K
A
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
M
R
V
I
F
A
---------
V
--
V
L
I
F
L
L
C
W
L
P
Y
N
-
L
V
L
L
A
D
T
L
M
R
----------
T
--
Q
VIQE
S
C
E
R
R
N
N
-
I
G
R
A
L
D
A
T
--------------------
E
I
L
G
F
L
H
S
C
L
----
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
72.31
18%
-165
* C5 *
4NL4
3
?
H:
[18-747]
SVAHVALPVPLPRTFDYLLPEGMAVKAGCRVRVPFGKQERIGIVAAVSERSELPLDELKPVAEALDDEPVFSTTVWRLLMWAAEYYHHPIGDVLFHALPVMLRQGKPASATPLWYWFATEQGQVVDLNGLKRSRKQQQALAALRQGKIWRHQVGELEFNEAALQALRGKGLAELACEATDWRSAYSVAGERLRL
N
--
T
E
Q
A
T
--
A
V
G
A
I
H
S
A
A
D
R
F
S
A
W
L
L
A
G
I
T
---
G
S
G
----
K
T
E
V
Y
L
S
V
-----------
L
E
N
V
L
A
Q
--
G
R
Q
A
L
V
----
M
V
P
EIG
L
T
-
P
Q
-
T
I
A
R
F
R
Q
R
F
N
A
P
V
E
-
V
L
H
S
G
L
N
------
D
S
-
E
R
L
S
A
W
-
L
K
-
A
K
N
G
E
A
A
I
V
I
-------
G
T
R
----
S
S
L
F
T
------------
P
F
K
D
L
-
G
V
I
V
I
D
E
E
H
D
S
S
Y
K
Q
Q
E
G
W
R
Y
--------
H
A
R
D
L
------------------------------
A
V
W
R
A
H
S
--
E
Q
I
P
I
I
L
G
SAT
P
---
A
L
E
T
L
H
N
V
R
Q
G
K
Y
R
-
Q
L
---
T
L
S
K
P
A
Q
-
Q
H
--------------------------------------------
V
L
D
L
K
G
------
Q
-
P
--
L
-
Q
A
G
L
S
P
A
L
I
S
R
-
M
R
Q
H
-
L
------
Q
A
D
N
Q
V
I
L
FLNRRGF
A
P
A
L
L
C
-
H
-
D
C
G
W
I
A
---------
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
P
R
C
D
S
-----------------
Y
Y
T
L
H
Q
A
-
Q
H
H
L
R
C
H
H
C
D
----------
S
--
Q
----------
R
-
P
I
P
R
Q
C
P
S
--------------------
C
G
S
T
H
L
V
P
V
----------
G
I
G
T
E
Q
L
E
Q
A
L
A
P
L
F
P
E
V
PISRIDRHLAAVHRGGARILIGTQMLAKGHHFPDVTLVSLLDVDGALFSADFRSAERFAQLYTQVSGRAGRAGKQGEVILQTHHPEHPLLQTLLYKGYDAFAEQALAERQTMQLPPWTSHVLIRAEDHNNQQAPLFLQQLRNLLQASPLADEKLWVLGPVPALRWQILLQHPSRVRLQHIVSGTLALINTLPEAWVLDVDPIEG
24
HHSearch
72.08
14%
-132
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
V
V
--
V
L
-----
S
T
I
C
L
V
T
V
G
--
L
N
L
L
V
L
----
Y
A
V
---
R
S
-
E
R
-
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
-
V
A
D
L
I
V
G
A
-
V
V
-
M
P
M
-
N
I
L
Y
L
L
-
M
S
-
K
W
S
L
G
R
P
L
C
L
-------
F
W
L
----
S
M
D
Y
V
-----------
A
S
T
A
S
I
-
F
S
V
F
I
L
-
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
------------------------------
A
T
I
L
G
A
W
--
F
L
S
F
L
W
V
I
---
P
---
I
L
G
W
N
H
----------
R
---
R
E
D
K
C
E
T
-
D
F
--------------------------------------------
Y
D
-------------------
V
T
W
F
K
V
M
T
A
-
I
I
N
F
-
Y
------
L
P
T
L
L
M
L
W
-------
F
Y
A
K
I
Y
-
K
-
A
V
R
Q
H
C
---------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
K
A
A
K
Q
L
G
F
---------
I
--
M
A
A
F
I
L
C
W
I
P
Y
F
-
I
F
F
M
V
I
A
F
C
K
----------
N
--
C
----------
C
-
N
E
H
L
H
M
F
T
--------------------
I
W
L
G
Y
I
N
S
T
L
----
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
72.00
17%
-131
- C4 -
3V2Y
1
ENLYS_BPT4
A:
[60-494]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----
N
S
I
K
L
T
S
V
--
V
F
-----
I
L
I
C
C
F
I
I
L
--
E
N
I
F
V
L
----
L
T
I
---
W
K
-
T
K
-
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
-
L
S
D
L
L
A
G
V
-
A
Y
-
T
A
N
-
L
L
L
S
G
A
--
T
-
T
Y
K
L
T
P
A
Q
W
F
-------
L
R
E
----
G
S
M
F
V
-----------
A
L
S
A
S
V
-
F
S
L
L
A
I
-
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
------------------------------
L
L
I
S
A
C
W
--
V
I
S
L
I
L
G
G
---
L
---
P
I
M
G
W
N
C
I
--------
S
---
A
L
S
S
C
S
T
-
V
L
--------------------------------------------
P
L
-------------------
Y
H
K
H
Y
I
L
F
C
-
T
T
V
F
-
T
------
L
L
L
L
S
I
V
I
-------
L
Y
C
R
I
Y
-
S
-
L
V
R
T
R
N
---------
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
A
L
L
K
T
V
I
I
---------
V
--
L
S
V
F
I
A
C
W
A
P
L
F
-
I
L
L
L
L
D
V
G
C
K
----------
V
KT
C
----------
D
-
I
L
F
R
A
E
Y
F
--------------------
L
V
L
A
V
L
N
S
G
T
----
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
68.46
17%
-145
* C3 *
4YHC
2
SCAP_SCHPO
A:
[2-468]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
W
S
D
H
D
--
E
L
S
--
T
D
T
T
L
H
E
E
K
F
R
I
E
P
V
P
VHH
Q
L
D
----
I
L
K
I
A
V
S
E
--
N
Y
-----
K
T
F
A
S
V
G
L
D
--
R
S
L
V
V
W
DLRQ
W
C
T
---
K
L
-
V
L
-
S
-
K
E
Q
M
P
R
T
L
K
A
I
A
-
L
D
P
Q
G
N
Y
V
-
S
L
-
F
S
K
D
T
L
F
I
L
N
-
V
E
-
S
P
S
L
M
L
Q
H
S
Y
H
S
KPN
S
K
L
N
V
----
F
W
M
P
G
THKDDE
W
K
N
F
E
L
V
V
V
E
S
S
G
E
I
Q
V
F
-
S
L
T
I
E
I
E
G
A
D
I
A
L
V
E
K
F
---
Q
L
S
S
P
I
I
------------------------------
K
S
I
S
I
V
S
PT
A
N
R
I
A
S
L
T
---
E
SG
E
V
T
V
Y
S
K
K
G
P
V
W
S
P
K
-
I
L
---
S
Q
N
K
N
Y
L
-
T
E
--------------------------------------------
T
K
K
-----------
D
--
I
-
Y
G
I
A
M
A
D
I
L
F
L
-
A
R
D
S
-
G
------
V
D
M
I
D
L
K
N
-------
D
E
L
L
H
S
-
F
-
T
L
P
P
I
K
---------
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----
F
S
V
G
V
S
N
S
R
F
V
NGQF
R
--
V
S
S
I
S
F
C
F
T
H
A
V
-
T
E
K
V
L
Y
Y
Y
Y
G
----------
N
--
E
----------
S
-
N
E
S
Y
I
I
L
N
KWDQQPNLVDVHDPDNS
L
A
S
L
T
F
D
E
L
Q
E
N
I
----
H
E
V
E
D
A
S
E
S
V
M
S
S
D
G
L
Y
I
F
G
M
R
R
K
S
S
S
G
ISG
E
T
Q
V
W
E
V
W
M
Y
SQSEK
K
H
R
S
K
S
L
K
M
Y
NSLIIADPGPSLAVSDR
C
V
A
I
V
LGN
Y
V
A
L
V
G
Y
GSEIFR-------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
66.73
13%
-127
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[44-494]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
----
F
N
K
I
F
L
P
T
--
I
Y
-----
S
I
I
F
L
T
G
I
V
--
G
N
G
L
V
I
----
L
V
M
---
G
Y
-
Q
K
-
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
-
V
A
D
L
L
F
V
--
I
T
-
L
P
F
-
W
A
V
D
A
V
--
A
-
N
W
Y
F
G
N
F
L
C
K
-------
A
V
H
----
V
I
Y
T
V
-----------
N
L
Y
S
S
V
-
W
I
L
A
F
I
-
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
------------------------------
V
V
Y
V
G
V
W
--
I
P
A
L
L
L
T
I
---
P
---
D
F
I
F
A
N
V
S
E
------
A
D
---
D
R
Y
I
C
D
R
-
F
Y
--------------------------------------------
P
N
---------------
D
-
L
W
V
V
V
F
Q
F
Q
H
I
-
M
V
G
L
-
I
------
L
P
G
I
V
I
L
S
-------
C
Y
C
I
I
I
-
S
-
K
L
S
H
S
G
---------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
---------
L
--
I
L
A
F
F
A
C
W
L
P
Y
Y
-
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
--
N
----------
T
-
V
H
K
W
I
S
I
T
--------------------
E
A
L
A
F
F
H
C
C
L
----
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
66.30
13%
-162
- C2 -
1IO2
-
RNH2_THEKO
A:
[1-213]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
A
G
I
D
---
E
A
G
----
R
G
---------------------
P
V
I
--
G
P
M
V
I
A
----
A
V
V
---
V
D
-
E
N
-
S
L
P
K
L
E
E
L
K
V
R
D
S
K
-
K
L
T
---------------------
P
-
K
R
R
E
K
L
F
N
E
I
-------
L
G
V
----------------------------------
L
D
D
Y
V
I
L
E
L
P
P
D
V
I
G
S
R
-----
E
G
T
L
N
------------------------------
E
F
E
V
E
N
F
--
A
K
A
L
N
S
L
--------
K
V
K
P
----
D
V
I
Y
A
D
-
A
A
---
D
V
D
E
E
R
F
-
A
R
--------------------------------------------
E
L
G
E
R
L
------
N
-
F
-----------
E
A
E
V
-
V
A
K
H
-
K
------
A
D
D
I
F
P
V
V
-------
S
A
A
S
I
L
-
A
-
K
V
T
R
D
R
---------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
K
E
E
Y
G
E
---------------------------------
I
G
S
G
Y
----------
P
--
S
----------
D
-
P
R
T
R
A
F
L
E
--------------------
N
Y
Y
R
E
H
G
E
F
P
----
P
I
V
R
K
G
W
--
K
T
L
K
K
I
A
E
K
V
E
S
E
K
K-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
62.79
14%
-101
- C5 -
4DQV
-
?
A:
[21-457]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEVHASDLTLDRFI
D
--
A
D
T
L
A
--
T
A
V
N
L
P
G
P
S
P
E
L
R
T
V
L
L
T
G
A
T
---
G
F
L
----
G
R
Y
L
V
L
E
L
--
L
R
R
LDVD
G
R
L
I
C
L
V
R
A
--
E
S
D
E
D
A
----
R
R
R
---
L
E
-
K
T
F
D
S
G
D
P
E
L
L
R
H
F
K
E
L
-
A
A
D
R
L
E
V
V
A
G
D
-
K
S
E
-
P
D
L
G
L
D
-
Q
P
M
W
R
R
L
A
E
T
V
D
L
-------
I
V
D
S
A
AM
V
N
A
F
P
-----------
Y
H
E
L
F
G
-
P
N
V
A
G
T
-
A
E
L
I
R
I
A
L
T
T
K
L
K
P
F
T
Y
---
V
S
T
A
D
V
G
AAIEPSAFTEDAD
I
R
V
I
S
P
T
R
T
V
D
GGWAGG
Y
G
T
S
K
W
A
--
G
E
V
L
L
R
E
A
---
N
---
D
L
C
A
L
-
P
V
A
V
F
R
C
G
M
I
L
A
D
T
S
Y
A
G
Q
L
N
M
S
D
W
V
T
R
M
V
L
S
L
M
A
T
GIAPRSFYEPDSEGNR
Q
R
A
H
F
DGLP
V
T
F
V
A
E
A
I
A
V
L
G
A
------
R
-
V
--
A
-
S
S
L
A
G
F
A
T
Y
H
V
M
N
P
H
D
-
D
------
G
I
G
L
D
E
Y
V
-------
D
W
L
I
E
A
G
Y
-
P
I
R
R
I
D
---------
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
W
L
Q
R
F
E
A
S
L
G
---------
A
--
L
P
D
R
Q
R
R
H
S
V
L
P
M
L
L
N
S
Q
R
L
Q
G
C
----------
S
--
A
----------
P
-
T
D
R
F
R
A
A
V
--------------------
R
A
A
K
V
G
S
D
K
D
----
N
P
D
I
P
H
V
S
A
P
T
I
I
N
Y
V
T
N
L
Q
L
L
G
LL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
58.83
26%
-132
- C4 -
4EIY
16
AA2AR_HUMAN (first)
A:
[24-145]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
P
---
P
I
M
----
G
S
S
V
Y
I
T
V
--
E
L
-----
A
-
I
A
V
L
A
I
L
--
G
N
V
L
V
C
----
W
A
V
---
W
L
-
N
S
-
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
-
A
A
D
I
A
V
G
V
----
L
A
I
-
P
F
A
I
T
I
-
S
T
-
G
F
C
A
A
C
H
G
C
L
-------
F
I
A
----
C
F
V
L
V
-----------
L
T
Q
S
S
I
-
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
------------------------------
G
I
I
A
I
C
W
--
V
L
S
F
A
I
G
L
---
T
---
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
-
K
N
---
H
S
Q
G
C
G
E
-
G
Q
--------------------------------------------
V
A
C
L
F
E
------
D
-
V
--
V
-
P
M
N
Y
M
V
Y
F
N
F
F
-
A
C
V
L
-
V
------
P
L
L
L
M
L
G
V
-------
Y
L
R
I
F
L
-
A
-
A
R
R
Q
L
A
---------
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
N
W
E
T
L
N
D
N
L
K
---------
V
--
I
E
K
A
D
N
A
A
Q
V
K
D
-
A
L
T
K
M
R
A
A
A
L
----------
D
--
A
----------
Q
-
K
M
K
D
F
R
H
G
--------------------
F
D
I
L
V
G
Q
I
D
D
----
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
53.92
27%
-133
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[19-120]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
I
L
--
G
N
V
L
V
C
----
W
A
V
---
W
L
-
N
S
-
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
-
A
A
D
I
A
V
G
V
----
L
A
I
-
P
F
A
I
T
I
-
S
T
-
G
F
C
A
A
C
H
G
C
L
-------
F
I
A
----
C
F
V
L
V
-----------
L
T
Q
S
S
I
-
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
------------------------------
G
I
I
A
I
C
W
--
V
L
S
F
A
I
G
L
---
T
---
P
M
L
G
W
N
N
C
G
Q
S
Q
G
C
-
G
E
---
G
Q
V
A
C
L
F
-
E
D
--------------------------------------------
V
V
P
M
N
Y
------
M
-
V
--
Y
-
F
N
F
F
A
C
V
L
V
P
L
-
L
L
M
L
-
G
------
V
Y
L
R
I
F
L
A
-------
A
R
R
Q
L
K
-
Q
-
M
E
S
Q
P
L
---------
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
---------
A
--
A
K
S
L
A
I
I
V
G
L
F
A
-
L
C
W
L
P
L
H
I
I
N
----------
C
--
F
----------
T
-
F
F
C
P
D
C
S
H
--------------------
A
P
L
W
L
M
Y
L
A
I
----
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------